TreeWAS – Variant ID: rs74469597

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems	0.513	0.487	0.000
O34 Maternal care for known or suspected abnormality of pelvic organs	0.507	0.493	0.000
O34.2 Maternal care due to uterine scar from previous surgery	0.494	0.506	0.000
Chapter XV Pregnancy, childbirth and the puerperium	0.489	0.511	0.000
O80-O84 Delivery	0.480	0.520	0.000
O80.0 Spontaneous vertex delivery	0.474	0.526	0.000
O80 Single spontaneous delivery	0.472	0.528	0.000
O20-O29 Other maternal disorders predominantly related to pregnancy	0.469	0.531	0.000
O32 Maternal care for known or suspected malpresentation of foetus	0.465	0.535	0.000
O42 Premature rupture of membranes	0.461	0.539	0.000
O26 Maternal care for other conditions predominantly related to pregnancy	0.458	0.542	0.000
O34.1 Maternal care for tumour of corpus uteri	0.452	0.548	0.000
O42.9 Premature rupture of membranes, unspecified	0.444	0.556	0.000
O40 Polyhydramnios	0.432	0.568	0.000
O47 False labour	0.427	0.573	0.000
O34.0 Maternal care for congenital malformation of uterus	0.427	0.573	0.000
O48 Prolonged pregnancy	0.426	0.574	0.000
O33 Maternal care for known or suspected disproportion	0.418	0.582	0.000
O26.9 Pregnancy-related condition, unspecified	0.415	0.585	0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium	0.412	0.588	0.000
O21 Excessive vomiting in pregnancy	0.407	0.593	0.000
O35 Maternal care for known or suspected foetal abnormality and damage	0.399	0.601	0.000
O26.0 Excessive weight gain in pregnancy	0.396	0.604	0.000
O81 Single delivery by forceps and vacuum extractor	0.393	0.607	0.000
O26.8 Other specified pregnancy-related conditions	0.388	0.612	0.000
O47.1 False labour at or after 37 completed weeks of gestation	0.381	0.619	0.000
O36 Maternal care for other known or suspected foetal problems	0.380	0.619	0.000
O32.2 Maternal care for transverse and oblique lie	0.377	0.623	0.000
O32.4 Maternal care for high head at term	0.376	0.624	0.000
O32.0 Maternal care for unstable lie	0.375	0.625	0.000
O45 Premature separation of placenta [abruptio placentae]	0.368	0.632	0.000
O31 Complications specific to multiple gestation	0.368	0.632	0.000
O34.3 Maternal care for cervical incompetence	0.368	0.632	0.000
O26.6 Liver disorders in pregnancy, childbirth and the puerperium	0.365	0.635	0.000
O85-O92 Complications predominantly related to the puerperium	0.365	0.635	0.000
O34.9 Maternal care for abnormality of pelvic organ, unspecified	0.364	0.636	0.000
O34.6 Maternal care for abnormality of vagina	0.364	0.636	0.000
O34.5 Maternal care for other abnormalities of gravid uterus	0.364	0.636	0.000
O32.1 Maternal care for breech presentation	0.355	0.645	0.000
O43 Placental disorders	0.355	0.645	0.000
O32.5 Maternal care for multiple gestation with malpresentation of one foetus or more	0.350	0.650	0.000
O33.9 Maternal care for disproportion, unspecified	0.350	0.650	0.000
O34.4 Maternal care for other abnormalities of cervix	0.349	0.651	0.000
O16 Unspecified maternal hypertension	0.349	0.651	0.000
O21.2 Late vomiting of pregnancy	0.348	0.651	0.000
O23 Infections of genito-urinary tract in pregnancy	0.348	0.652	0.000
O32.9 Maternal care for malpresentation of foetus, unspecified	0.348	0.652	0.000
O41 Other disorders of amniotic fluid and membranes	0.345	0.655	0.000
O22 Venous complications in pregnancy	0.344	0.655	0.000
O84 Multiple delivery	0.344	0.655	0.000
O83 Other assisted single delivery	0.344	0.655	0.000
O30 Multiple gestation	0.344	0.656	0.000
O34.8 Maternal care for other abnormalities of pelvic organs	0.343	0.657	0.000
O42.1 Premature rupture of membranes, onset of labour after 24 hours	0.341	0.659	0.000
O13 Gestational [pregnancy-induced] hypertension without significant proteinuria	0.339	0.661	0.000
O80.1 Spontaneous breech delivery	0.339	0.661	0.000
O32.3 Maternal care for face, brow and chin presentation	0.339	0.661	0.000
O29 Complications of anaesthesia during pregnancy	0.337	0.663	0.000
O25 Malnutrition in pregnancy	0.337	0.663	0.000
O32.6 Maternal care for compound presentation	0.333	0.667	0.000
O35.1 Maternal care for (suspected) chromosomal abnormality in foetus	0.333	0.667	0.000
O26.2 Pregnancy care of habitual aborter	0.332	0.668	0.000
O42.2 Premature rupture of membranes, labour delayed by therapy	0.330	0.669	0.000
O81.4 Vacuum extractor delivery	0.331	0.669	0.000
O36.6 Maternal care for excessive foetal growth	0.330	0.670	0.000
O10 Pre-existing hypertension complicating pregnancy, childbirth and the puerperium	0.329	0.671	0.000
O26.5 Maternal hypotension syndrome	0.329	0.671	0.000
O26.4 Herpes gestationis	0.329	0.671	0.000
O26.3 Retained intra-uterine contraceptive device in pregnancy	0.329	0.671	0.000
O26.1 Low weight gain in pregnancy	0.329	0.671	0.000
O21.9 Vomiting of pregnancy, unspecified	0.323	0.677	0.000
O82 Single delivery by Caesarean section	0.319	0.680	0.000
O47.9 False labour, unspecified	0.319	0.681	0.000
O26.7 Subluxation of symphysis (pubis) in pregnancy, childbirth and the puerperium	0.312	0.688	0.000
O80.8 Other single spontaneous delivery	0.306	0.694	0.000
O28 Abnormal findings on antenatal screening of mother	0.301	0.698	0.000
O36.8 Maternal care for other specified foetal problems	0.301	0.699	0.000
O33.8 Maternal care for disproportion of other origin	0.300	0.700	0.000
O33.7 Maternal care for disproportion due to other foetal deformities	0.300	0.700	0.000
O33.6 Maternal care for disproportion due to hydrocephalic foetus	0.300	0.700	0.000
O33.5 Maternal care for disproportion due to unusually large foetus	0.300	0.700	0.000
O33.4 Maternal care for disproportion of mixed maternal and foetal origin	0.300	0.700	0.000
O33.3 Maternal care for disproportion due to outlet contraction of pelvis	0.300	0.700	0.000
O33.2 Maternal care for disproportion due to inlet contraction of pelvis	0.300	0.700	0.000
O33.1 Maternal care for disproportion due to generally contracted pelvis	0.300	0.700	0.000
O33.0 Maternal care for disproportion due to deformity of maternal pelvic bones	0.300	0.700	0.000
O36.0 Maternal care for rhesus isoimmunisation	0.299	0.701	0.000
O94-O99 Other obstetric conditions, not elsewhere classified	0.296	0.704	0.000
O15 Eclampsia	0.296	0.704	0.000
O11 Pre-existing hypertensive disorder with superimposed proteinuria	0.296	0.704	0.000
O34.7 Maternal care for abnormality of vulva and perineum	0.295	0.705	0.000
O21.8 Other vomiting complicating pregnancy	0.292	0.708	0.000
O21.1 Hyperemesis gravidarum with metabolic disturbance	0.292	0.708	0.000
O21.0 Mild hyperemesis gravidarum	0.287	0.712	0.000
O35.7 Maternal care for (suspected) damage to foetus by other medical procedures	0.286	0.714	0.000
O35.6 Maternal care for (suspected) damage to foetus by radiation	0.286	0.714	0.000
O35.5 Maternal care for (suspected) damage to foetus by drugs	0.286	0.714	0.000
O35.4 Maternal care for (suspected) damage to foetus from alcohol	0.286	0.714	0.000
O35.3 Maternal care for (suspected) damage to foetus from viral disease in mother	0.286	0.714	0.000
O35.2 Maternal care for (suspected) hereditary disease in foetus	0.286	0.714	0.000
O35.0 Maternal care for (suspected) central nervous system malformation in foetus	0.286	0.714	0.000
O92 Other disorders of breast and lactation associated with childbirth	0.286	0.714	0.000
O43.9 Placental disorder, unspecified	0.284	0.716	0.000
O35.9 Maternal care for (suspected) foetal abnormality and damage, unspecified	0.282	0.718	0.000
O81.5 Delivery by combination of forceps and vacuum extractor	0.282	0.718	0.000
O81.3 Other and unspecified forceps delivery	0.282	0.718	0.000
O81.2 Mid-cavity forceps with rotation	0.282	0.718	0.000
O81.1 Mid-cavity forceps delivery	0.282	0.718	0.000
O81.0 Low forceps delivery	0.282	0.718	0.000
O32.8 Maternal care for other malpresentation of foetus	0.281	0.718	0.000
O24 Diabetes mellitus in pregnancy	0.277	0.722	0.000
O36.7 Maternal care for viable foetus in abdominal pregnancy	0.273	0.727	0.000
O36.2 Maternal care for hydrops foetalis	0.273	0.727	0.000
O36.1 Maternal care for other isoimmunisation	0.273	0.727	0.000
O36.3 Maternal care for signs of foetal hypoxia	0.272	0.728	0.000
O86 Other puerperal infections	0.270	0.730	0.000
O41.8 Other specified disorders of amniotic fluid and membranes	0.270	0.730	0.000
O10.0 Pre-existing essential hypertension complicating pregnancy, childbirth and the puerperium	0.269	0.731	0.000
O35.8 Maternal care for other (suspected) foetal abnormality and damage	0.266	0.734	0.000
O46 Antepartum haemorrhage, not elsewhere classified	0.264	0.736	0.000
O31.8 Other complications specific to multiple gestation	0.264	0.736	0.000
O31.2 Continuing pregnancy after intra-uterine death of one foetus or more	0.264	0.736	0.000
O31.1 Continuing pregnancy after abortion of one foetus or more	0.264	0.736	0.000
O31.0 Papyraceous foetus	0.264	0.736	0.000
O45.9 Premature separation of placenta, unspecified	0.264	0.736	0.000
O45.8 Other premature separation of placenta	0.264	0.736	0.000
O45.0 Premature separation of placenta with coagulation defect	0.264	0.736	0.000
O12 Gestational [pregnancy-induced] oedema and proteinuria without hypertension	0.263	0.737	0.000
O91 Infections of breast associated with childbirth	0.262	0.738	0.000
O89 Complications of anaesthesia during the puerperium	0.262	0.738	0.000
O88 Obstetric embolism	0.262	0.738	0.000
O87 Venous complications in the puerperium	0.262	0.738	0.000
O23.4 Unspecified infection of urinary tract in pregnancy	0.261	0.739	0.000
O85 Puerperal sepsis	0.259	0.741	0.000
O20 Haemorrhage in early pregnancy	0.258	0.742	0.000
O22.4 Haemorrhoids in pregnancy	0.255	0.745	0.000
O43.2 Morbidly adherent placenta	0.255	0.745	0.000
O43.0 Placental transfusion syndromes	0.255	0.745	0.000
O23.5 Infections of the genital tract in pregnancy	0.251	0.749	0.000
O47.0 False labour before 37 completed weeks of gestation	0.250	0.750	0.000
O23.9 Other and unspecified genito-urinary tract infection in pregnancy	0.250	0.750	0.000
O23.3 Infections of other parts of urinary tract in pregnancy	0.250	0.750	0.000
O23.2 Infections of urethra in pregnancy	0.250	0.750	0.000
O23.1 Infections of bladder in pregnancy	0.250	0.750	0.000
O23.0 Infections of kidney in pregnancy	0.250	0.750	0.000
O41.9 Disorder of amniotic fluid and membranes, unspecified	0.247	0.753	0.000
O41.1 Infection of amniotic sac and membranes	0.247	0.753	0.000
O22.9 Venous complication in pregnancy, unspecified	0.247	0.753	0.000
O22.8 Other venous complications in pregnancy	0.247	0.753	0.000
O22.5 Cerebral venous thrombosis in pregnancy	0.247	0.753	0.000
O22.3 Deep phlebothrombosis in pregnancy	0.247	0.753	0.000
O22.2 Superficial thrombophlebitis in pregnancy	0.247	0.753	0.000
O22.1 Genital varices in pregnancy	0.247	0.753	0.000
O22.0 Varicose veins of lower extremity in pregnancy	0.247	0.753	0.000
O83.9 Assisted single delivery, unspecified	0.247	0.753	0.000
O83.8 Other specified assisted single delivery	0.247	0.753	0.000
O83.4 Destructive operation for delivery	0.247	0.753	0.000
O83.3 Delivery of viable foetus in abdominal pregnancy	0.247	0.753	0.000
O83.2 Other manipulation-assisted delivery	0.247	0.753	0.000
O83.1 Other assisted breech delivery	0.247	0.753	0.000
O83.0 Breech extraction	0.247	0.753	0.000
O84.9 Multiple delivery, unspecified	0.247	0.753	0.000
O84.8 Other multiple delivery	0.247	0.753	0.000
O84.2 Multiple delivery, all by Caesarean section	0.247	0.753	0.000
O84.1 Multiple delivery, all by forceps and vacuum extractor	0.247	0.753	0.000
O84.0 Multiple delivery, all spontaneous	0.247	0.753	0.000
O44 Placenta praevia	0.247	0.753	0.001
O30.9 Multiple gestation, unspecified	0.247	0.753	0.000
O30.8 Other multiple gestation	0.247	0.753	0.000
O30.2 Quadruplet pregnancy	0.247	0.753	0.000
O30.1 Triplet pregnancy	0.247	0.753	0.000
O36.4 Maternal care for intra-uterine death	0.245	0.755	0.000
O43.8 Other placental disorders	0.243	0.757	0.000
O80.9 Single spontaneous delivery, unspecified	0.243	0.757	0.000
O90 Complications of the puerperium, not elsewhere classified	0.242	0.757	0.000
O29.9 Complication of anaesthesia during pregnancy, unspecified	0.241	0.758	0.000
O29.8 Other complications of anaesthesia during pregnancy	0.241	0.758	0.000
O29.6 Failed or difficult intubation during pregnancy	0.241	0.758	0.000
O29.5 Other complications of spinal and epidural anaesthesia during pregnancy	0.241	0.758	0.000
O29.4 Spinal and epidural anaesthesia-induced headache during pregnancy	0.241	0.758	0.000
O29.3 Toxic reaction to local anaesthesia during pregnancy	0.241	0.758	0.000
O29.2 Central nervous system complications of anaesthesia during pregnancy	0.241	0.758	0.000
O29.1 Cardiac complications of anaesthesia during pregnancy	0.241	0.758	0.000
O29.0 Pulmonary complications of anaesthesia during pregnancy	0.241	0.758	0.000
O36.5 Maternal care for poor foetal growth	0.241	0.759	0.000
O82.1 Delivery by emergency Caesarean section	0.240	0.760	0.000
O14 Gestational [pregnancy-induced] hypertension with significant proteinuria	0.240	0.760	0.000
O10.9 Unspecified pre-existing hypertension complicating pregnancy, childbirth and the puerperium	0.236	0.764	0.000
O10.4 Pre-existing secondary hypertension complicating pregnancy, childbirth and the puerperium	0.236	0.764	0.000
O10.3 Pre-existing hypertensive heart and renal disease complicating pregnancy, childbirth and the puerperium	0.236	0.764	0.000
O10.2 Pre-existing hypertensive renal disease complicating pregnancy, childbirth and the puerperium	0.236	0.764	0.000
O10.1 Pre-existing hypertensive heart disease complicating pregnancy, childbirth and the puerperium	0.236	0.764	0.000
O82.8 Other single delivery by Caesarean section	0.229	0.771	0.000
O82.2 Delivery by Caesarean hysterectomy	0.229	0.771	0.000
O92.2 Other and unspecified disorders of breast associated with childbirth	0.229	0.771	0.000
O30.0 Twin pregnancy	0.223	0.777	0.000
O28.9 Abnormal finding on antenatal screening of mother, unspecified	0.216	0.784	0.000
O28.8 Other abnormal findings on antenatal screening of mother	0.216	0.784	0.000
O28.5 Abnormal chromosomal and genetic finding on antenatal screening of mother	0.216	0.784	0.000
O28.4 Abnormal radiological finding on antenatal screening of mother	0.216	0.784	0.000
O28.3 Abnormal ultrasonic finding on antenatal screening of mother	0.216	0.784	0.000
O28.2 Abnormal cytological finding on antenatal screening of mother	0.216	0.784	0.000
O28.0 Abnormal haematological finding on antenatal screening of mother	0.216	0.784	0.000
O82.0 Delivery by elective Caesarean section	0.215	0.785	0.000
O86.4 Pyrexia of unknown origin following delivery	0.215	0.785	0.000
O98 Maternal infectious and parasitic diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium	0.212	0.787	0.000
O97 Death from sequelae of direct obstetric causes	0.212	0.787	0.000
O96 Death from any obstetric cause occurring more than 42 days but less than one year after delivery	0.212	0.787	0.000
O95 Obstetric death of unspecified cause	0.212	0.787	0.000
O94 Sequelae of complication of pregnancy, childbirth and the puerperium	0.212	0.787	0.000
O15.9 Eclampsia, unspecified as to time period	0.212	0.788	0.000
O15.2 Eclampsia in the puerperium	0.212	0.788	0.000
O15.1 Eclampsia in labour	0.212	0.788	0.000
O15.0 Eclampsia in pregnancy	0.212	0.788	0.000
O43.1 Malformation of placenta	0.211	0.789	0.000
O82.9 Delivery by Caesarean section, unspecified	0.206	0.794	0.000
O92.7 Other and unspecified disorders of lactation	0.205	0.795	0.000
O92.6 Galactorrhoea	0.205	0.795	0.000
O92.5 Suppressed lactation	0.205	0.795	0.000
O92.4 Hypogalactia	0.205	0.795	0.000
O92.3 Agalactia	0.205	0.795	0.000
O92.1 Cracked nipple associated with childbirth	0.205	0.795	0.000
O92.0 Retracted nipple associated with childbirth	0.205	0.795	0.000
O24.9 Diabetes mellitus in pregnancy, unspecified	0.199	0.801	0.000
O24.3 Pre-existing diabetes mellitus, unspecified	0.199	0.801	0.000
O24.2 Pre-existing malnutrition-related diabetes mellitus	0.199	0.801	0.000
O24.1 Pre-existing diabetes mellitus, noninsulin-dependent	0.199	0.801	0.000
O24.0 Pre-existing diabetes mellitus, insulin-dependent	0.199	0.801	0.000
O46.8 Other antepartum haemorrhage	0.198	0.801	0.000
O86.8 Other specified puerperal infections	0.194	0.806	0.000
O86.3 Other genito-urinary tract infections following delivery	0.194	0.806	0.000
O86.2 Urinary tract infection following delivery	0.194	0.806	0.000
O86.1 Other infection of genital tract following delivery	0.194	0.806	0.000
O46.0 Antepartum haemorrhage with coagulation defect	0.189	0.810	0.000
O12.2 Gestational oedema with proteinuria	0.188	0.811	0.000
O87.9 Venous complication in the puerperium, unspecified	0.188	0.812	0.000
O87.8 Other venous complications in the puerperium	0.188	0.812	0.000
O87.3 Cerebral venous thrombosis in the puerperium	0.188	0.812	0.000
O87.2 Haemorrhoids in the puerperium	0.188	0.812	0.000
O87.1 Deep phlebothrombosis in the puerperium	0.188	0.812	0.000
O87.0 Superficial thrombophlebitis in the puerperium	0.188	0.812	0.000
O88.8 Other obstetric embolism	0.188	0.812	0.000
O88.3 Obstetric pyaemic and septic embolism	0.188	0.812	0.000
O88.2 Obstetric blood-clot embolism	0.188	0.812	0.000
O88.1 Amniotic fluid embolism	0.188	0.812	0.000
O88.0 Obstetric air embolism	0.188	0.812	0.000
O89.9 Complication of anaesthesia during the puerperium, unspecified	0.188	0.812	0.000
O89.8 Other complications of anaesthesia during the puerperium	0.188	0.812	0.000
O89.6 Failed or difficult intubation during the puerperium	0.188	0.812	0.000
O89.5 Other complications of spinal and epidural anaesthesia during the puerperium	0.188	0.812	0.000
O89.4 Spinal and epidural anaesthesia-induced headache during the puerperium	0.188	0.812	0.000
O89.3 Toxic reaction to local anaesthesia during the puerperium	0.188	0.812	0.000
O89.2 Central nervous system complications of anaesthesia during the puerperium	0.188	0.812	0.000
O89.1 Cardiac complications of anaesthesia during the puerperium	0.188	0.812	0.000
O89.0 Pulmonary complications of anaesthesia during the puerperium	0.188	0.812	0.000
O91.2 Nonpurulent mastitis associated with childbirth	0.188	0.812	0.000
O91.1 Abscess of breast associated with childbirth	0.188	0.812	0.000
O91.0 Infection of nipple associated with childbirth	0.188	0.812	0.000
O41.0 Oligohydramnios	0.188	0.812	0.000
O12.1 Gestational proteinuria	0.184	0.816	0.000
O90.1 Disruption of perineal obstetric wound	0.184	0.816	0.000
O90.9 Complication of the puerperium, unspecified	0.183	0.816	0.000
O20.0 Threatened abortion	0.181	0.819	0.000
O28.1 Abnormal biochemical finding on antenatal screening of mother	0.181	0.819	0.000
O14.1 Severe preeclampsia	0.179	0.821	0.000
O20.8 Other haemorrhage in early pregnancy	0.178	0.821	0.000
O86.0 Infection of obstetric surgical wound	0.177	0.823	0.000
O90.5 Postpartum thyroiditis	0.174	0.826	0.000
O90.4 Postpartum acute renal failure	0.174	0.826	0.000
O90.3 Cardiomyopathy in the puerperium	0.174	0.826	0.000
O90.2 Haematoma of obstetric wound	0.174	0.826	0.000
O90.0 Disruption of Caesarean section wound	0.174	0.826	0.000
O14.2 HELLP syndrome	0.172	0.828	0.000
O14.0 Moderate preeclampsia	0.168	0.831	0.000
O42.0 Premature rupture of membranes, onset of labour within 24 hours	0.163	0.836	0.000
O36.9 Maternal care for foetal problem, unspecified	0.161	0.838	0.000
O12.0 Gestational oedema	0.161	0.838	0.000
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium	0.158	0.842	0.000
O96.9 Death from unspecified obstetric cause	0.152	0.847	0.000
O96.1 Death from indirect obstetric cause	0.152	0.847	0.000
O96.0 Death from direct obstetric cause	0.152	0.847	0.000
O97.9 Death from sequelae of obstetric cause, unspecified	0.152	0.847	0.000
O97.1 Death from sequelae of indirect obstetric cause	0.152	0.847	0.000
O97.0 Death from sequelae of direct obstetric cause	0.152	0.847	0.000
O98.9 Unspecified maternal infectious or parasitic disease complicating pregnancy, childbirth and the puerperium	0.152	0.847	0.000
O98.8 Other maternal infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium	0.152	0.847	0.000
O98.7 Human immunodeficiency [HIV] disease complicating pregnancy, childbirth and the puerperium	0.152	0.847	0.000
O98.6 Protozoal diseases complicating pregnancy, childbirth and the puerperium	0.152	0.847	0.000
O98.5 Other viral diseases complicating pregnancy, childbirth and the puerperium	0.152	0.847	0.000
O98.4 Viral hepatitis complicating pregnancy, childbirth and the puerperium	0.152	0.847	0.000
O98.3 Other infections with a predominantly sexual mode of transmission complicating pregnancy, childbirth and the puerperium	0.152	0.847	0.000
O98.2 Gonorrhoea complicating pregnancy, childbirth and the puerperium	0.152	0.847	0.000
O98.1 Syphilis complicating pregnancy, childbirth and the puerperium	0.152	0.847	0.000
O98.0 Tuberculosis complicating pregnancy, childbirth and the puerperium	0.152	0.847	0.000
O00-O08 Pregnancy with abortive outcome	0.146	0.854	0.000
O44.0 Placenta praevia specified as without haemorrhage	0.145	0.854	0.001
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.143	0.857	0.000
O99.5 Diseases of the respiratory system complicating pregnancy, childbirth and the puerperium	0.141	0.859	0.000
O24.4 Diabetes mellitus arising in pregnancy	0.140	0.860	0.001
M50-M54 Other dorsopathies	0.140	0.860	0.000
M20-M25 Other joint disorders	0.135	0.865	0.000
M80-M85 Disorders of bone density and structure	0.134	0.866	0.000
M45-M49 Spondylopathies	0.134	0.866	0.000
M86-M90 Other osteopathies	0.132	0.868	0.000
M24 Other specific joint derangements	0.132	0.868	0.000
M80 Osteoporosis with pathological fracture	0.130	0.870	0.000
M54.22 Cervicalgia (Cervical region)	0.130	0.870	0.000
M51 Other intervertebral disk disorders	0.129	0.871	0.000
M54 Dorsalgia	0.127	0.873	0.000
M80.9 Unspecified osteoporosis with pathological fracture	0.126	0.874	0.000
M20 Acquired deformities of fingers and toes	0.126	0.874	0.000
M54.2 Cervicalgia	0.126	0.874	0.000
O20.9 Haemorrhage in early pregnancy, unspecified	0.126	0.874	0.000
O90.8 Other complications of the puerperium, not elsewhere classified	0.123	0.876	0.001
M80.90 Unspecified osteoporosis with pathological fracture (Multiple sites)	0.124	0.876	0.000
M48 Other spondylopathies	0.122	0.878	0.000
O99.3 Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium	0.122	0.878	0.000
O99.6 Diseases of the digestive system complicating pregnancy, childbirth and the puerperium	0.122	0.878	0.000
M20.5 Other deformities of toe(s) (acquired)	0.121	0.879	0.000
M24.1 Other articular cartilage disorders	0.119	0.881	0.000
M51.0 Lumbar and other intervertebral disk disorders with myelopathy	0.119	0.881	0.000
M31 Other necrotising vasculopathies	0.118	0.882	0.000
M24.8 Other specific joint derangements, not elsewhere classified	0.117	0.883	0.000
O44.1 Placenta praevia with haemorrhage	0.116	0.884	0.001
M91-M94 Chondropathies	0.116	0.884	0.000
O60-O75 Complications of labour and delivery	0.115	0.885	0.000
O99.7 Diseases of the skin and subcutaneous tissue complicating pregnancy, childbirth and the puerperium	0.113	0.886	0.000
O99.4 Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium	0.113	0.886	0.000
M20.0 Deformity of finger(s)	0.114	0.886	0.000
M90 Osteopathies in diseases classified elsewhere	0.113	0.887	0.000
M89 Other disorders of bone	0.113	0.887	0.000
# Top node	0.112	0.888	0.000
M47 Spondylosis	0.112	0.888	0.000
O99.2 Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium	0.111	0.889	0.000
Chapter XX External causes of morbidity and mortality	0.111	0.889	0.000
M20.3 Other deformity of hallux (acquired)	0.111	0.889	0.000
O14.9 Preeclampsia, unspecified	0.110	0.889	0.000
M47.9 Spondylosis, unspecified	0.109	0.891	0.000
M24.0 Loose body in joint	0.109	0.891	0.000
M34 Systemic sclerosis	0.109	0.891	0.000
M24.16 Other articular cartilage disorders (Lower leg)	0.108	0.892	0.000
M24.7 Protrusio acetabuli	0.106	0.893	0.000
M48.5 Collapsed vertebra, not elsewhere classified	0.105	0.894	0.000
M50 Cervical disk disorders	0.105	0.895	0.000
M86 Osteomyelitis	0.105	0.895	0.000
O99.1 Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium	0.105	0.895	0.000
O08 Complications following abortion and ectopic and molar pregnancy	0.105	0.895	0.000
O07 Failed attempted abortion	0.105	0.895	0.000
O06 Unspecified abortion	0.105	0.895	0.000
O05 Other abortion	0.105	0.895	0.000
O01 Hydatidiform mole	0.105	0.895	0.000
M47.99 Spondylosis, unspecified (Site unspecified)	0.105	0.895	0.000
M54.8 Other dorsalgia	0.104	0.896	0.000
M48.0 Spinal stenosis	0.104	0.896	0.000
M60-M63 Disorders of muscles	0.104	0.896	0.000
Chapter VI Diseases of the nervous system	0.104	0.896	0.000
M70-M79 Other soft tissue disorders	0.104	0.896	0.000
Chapter V Mental and behavioural disorders	0.103	0.897	0.000
M51.4 Schmorl's nodes	0.103	0.897	0.000
M51.8 Other specified intervertebral disk disorders	0.103	0.897	0.000
M80.5 Idiopathic osteoporosis with pathological fracture	0.103	0.897	0.000
M87 Osteonecrosis	0.103	0.897	0.000
M24.87 Other specific joint derangements, not elsewhere classified (Ankle and foot)	0.103	0.897	0.000
O03 Spontaneous abortion	0.102	0.898	0.000
M82 Osteoporosis in diseases classified elsewhere	0.102	0.898	0.000
M85 Other disorders of bone density and structure	0.102	0.898	0.000
M46 Other inflammatory spondylopathies	0.102	0.898	0.000
M31.5 Giant cell arteritis with polymyalgia rheumatica	0.102	0.898	0.000
O62 Abnormalities of forces of labour	0.101	0.899	0.000
G90-G99 Other disorders of the nervous system	0.101	0.899	0.000
M33 Dermatopolymyositis	0.101	0.899	0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.100	0.900	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.100	0.900	0.000
M53 Other dorsopathies, not elsewhere classified	0.100	0.900	0.000
M90.7 Fracture of bone in neoplastic disease	0.099	0.900	0.000
W00-W19 Falls	0.099	0.901	0.000
V80-V89 Other land transport accidents	0.098	0.902	0.000
M80.8 Other osteoporosis with pathological fracture	0.098	0.902	0.000
M24.15 Other articular cartilage disorders (Pelvic region and thigh)	0.098	0.902	0.000
O75 Other complications of labour and delivery, not elsewhere classified	0.098	0.902	0.000
M20.4 Other hammer toe(s) (acquired)	0.098	0.902	0.000
M80.0 Postmenopausal osteoporosis with pathological fracture	0.097	0.903	0.000
M54.4 Lumbago with sciatica	0.097	0.903	0.000
G95 Other diseases of spinal cord	0.097	0.903	0.000
M80.98 Unspecified osteoporosis with pathological fracture (Other)	0.097	0.903	0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.097	0.903	0.000
M30 Polyarteritis nodosa and related conditions	0.097	0.903	0.000
M00-M03 Infectious arthropathies	0.097	0.903	0.000
M49 Spondylopathies in diseases classified elsewhere	0.096	0.904	0.000
M83 Adult osteomalacia	0.096	0.904	0.000
W50-W64 Exposure to animate mechanical forces	0.096	0.904	0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use	0.096	0.904	0.000
M54.1 Radiculopathy	0.096	0.904	0.000
M24.6 Ankylosis of joint	0.096	0.904	0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.096	0.904	0.000
Chapter VIII Diseases of the ear and mastoid process	0.095	0.905	0.000
M24.9 Joint derangement, unspecified	0.095	0.905	0.000
M31.6 Other giant cell arteritis	0.095	0.905	0.000
M24.5 Contracture of joint	0.095	0.905	0.000
M24.2 Disorder of ligament	0.094	0.906	0.000
F40-F48 Neurotic, stress-related and somatoform disorders	0.094	0.906	0.000
M65-M68 Disorders of synovium and tendon	0.094	0.906	0.000
M50.2 Other cervical disk displacement	0.093	0.907	0.000
M80.4 Drug-induced osteoporosis with pathological fracture	0.093	0.907	0.000
M80.3 Postsurgical malabsorption osteoporosis with pathological fracture	0.093	0.907	0.000
M80.2 Osteoporosis of disuse with pathological fracture	0.093	0.907	0.000
M32 Systemic lupus erythematosus	0.093	0.907	0.000
M80.99 Unspecified osteoporosis with pathological fracture (Site unspecified)	0.093	0.907	0.000
M89.8 Other specified disorders of bone	0.093	0.907	0.000
M51.3 Other specified intervertebral disk degeneration	0.092	0.907	0.000
M51.1 Lumbar and other intervertebral disk disorders with radiculopathy	0.092	0.907	0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.092	0.908	0.000
M20.6 Acquired deformity of toe(s), unspecified	0.092	0.908	0.000
M24.11 Other articular cartilage disorders (Shoulder region)	0.092	0.908	0.000
X50-X57 Overexertion, travel and privation	0.092	0.908	0.000
M77 Other enthesopathies	0.092	0.908	0.000
M24.01 Loose body in joint (Shoulder region)	0.091	0.908	0.000
O73 Retained placenta and membranes, without haemorrhage	0.091	0.909	0.000
M91 Juvenile osteochondrosis of hip and pelvis	0.091	0.909	0.000
M48.06 Spinal stenosis (Lumbar region)	0.091	0.909	0.000
M54.0 Panniculitis affecting regions of neck and back	0.091	0.909	0.000
M80.97 Unspecified osteoporosis with pathological fracture (Ankle and foot)	0.091	0.909	0.000
M80.96 Unspecified osteoporosis with pathological fracture (Lower leg)	0.091	0.909	0.000
M80.95 Unspecified osteoporosis with pathological fracture (Pelvic region and thigh)	0.091	0.909	0.000
M80.94 Unspecified osteoporosis with pathological fracture (Hand)	0.091	0.909	0.000
M80.93 Unspecified osteoporosis with pathological fracture (Forearm)	0.091	0.909	0.000
M80.92 Unspecified osteoporosis with pathological fracture (Upper arm)	0.091	0.909	0.000
M80.91 Unspecified osteoporosis with pathological fracture (Shoulder region)	0.091	0.909	0.000
G00-G09 Inflammatory diseases of the central nervous system	0.091	0.909	0.000
M54.28 Cervicalgia-Sacral/sacrococ	0.091	0.909	0.000
M54.27 Cervicalgia-Lumbosacral	0.091	0.909	0.000
M54.26 Cervicalgia-Lumbar	0.091	0.909	0.000
M54.25 Cervicalgia-Thoracolumbar	0.091	0.909	0.000
M54.24 Cervicalgia-Thoracic	0.091	0.909	0.000
M54.23 Cervicalgia (Cervicothoracic region)	0.091	0.909	0.000
M54.21 Cervicalgia (Occipito-atlanto-axial region)	0.091	0.909	0.000
M54.20 Cervicalgia-Mult site	0.091	0.909	0.000
G70-G73 Diseases of myoneural junction and muscle	0.090	0.910	0.000
M47.97 Spondylosis, unspecified (Lumbosacral region)	0.090	0.910	0.000
M40-M43 Deforming dorsopathies	0.090	0.910	0.000
M89.0 Algoneurodystrophy	0.090	0.910	0.000
G98 Other disorders of nervous system, not elsewhere classified	0.090	0.910	0.000
M35 Other systemic involvement of connective tissue	0.090	0.910	0.000
M24.02 Loose body in joint (Upper arm)	0.090	0.910	0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.090	0.910	0.000
M24.86 Other specific joint derangements, not elsewhere classified (Lower leg)	0.090	0.910	0.000
M45 Ankylosing spondylitis	0.089	0.910	0.000
H60-H62 Diseases of external ear	0.089	0.911	0.000
V20-V29 Motorcycle rider injured in transport accident	0.089	0.911	0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.089	0.911	0.000
O62.3 Precipitate labour	0.089	0.911	0.000
M34.8 Other forms of systemic sclerosis	0.089	0.911	0.000
Y60-Y69 Misadventures to patients during surgical and medical care	0.089	0.911	0.000
M93 Other osteochondropathies	0.088	0.911	0.000
Y52 Agents primarily affecting the cardiovascular system	0.088	0.912	0.000
M24.75 Protrusio acetabuli-Pelvic/thigh	0.088	0.912	0.000
Y00-Y09 Assault	0.088	0.912	0.000
M54.84 Other dorsalgia (Thoracic region)	0.088	0.912	0.000
F42 Obsessive-compulsive disorder	0.088	0.912	0.000
M54.3 Sciatica	0.088	0.912	0.000
O62.2 Other uterine inertia	0.088	0.912	0.000
V89 Motor- or nonmotor-vehicle accident, type of vehicle unspecified	0.088	0.912	0.000
M92 Other juvenile osteochondrosis	0.088	0.912	0.000
M34.1 CR(E)ST syndrome	0.088	0.912	0.000
M48.9 Spondylopathy, unspecified	0.088	0.912	0.000
M48.8 Other specified spondylopathies	0.088	0.912	0.000
M48.4 Fatigue fracture of vertebra	0.088	0.912	0.000
M48.3 Traumatic spondylopathy	0.088	0.912	0.000
M48.2 Kissing spine	0.088	0.912	0.000
M48.1 Ankylosing hyperostosis [Forestier]	0.088	0.912	0.000
M48.54 Collapsed vertebra, not elsewhere classified (Thoracic region)	0.088	0.912	0.000
G95.2 Cord compression, unspecified	0.088	0.912	0.000
W13 Fall from, out of or through building or structure	0.088	0.912	0.000
G50-G59 Nerve, nerve root and plexus disorders	0.087	0.913	0.000
S20-S29 Injuries to the thorax	0.087	0.913	0.000
M54.47 Lumbago with sciatica (Lumbosacral region)	0.087	0.913	0.000
M24.4 Recurrent dislocation and subluxation of joint	0.087	0.913	0.000
O75.6 Delayed delivery after spontaneous or unspecified rupture of membranes	0.087	0.913	0.000
M24.85 Other specific joint derangements, not elsewhere classified (Pelvic region and thigh)	0.087	0.913	0.000
X58-X59 Accidental exposure to other and unspecified factors	0.087	0.913	0.000
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified	0.086	0.914	0.000
M47.94 Spondylosis, unspecified (Thoracic region)	0.086	0.914	0.000
M51.9 Intervertebral disk disorder, unspecified	0.086	0.914	0.000
M47.92 Spondylosis, unspecified (Cervical region)	0.086	0.914	0.000
M71 Other bursopathies	0.086	0.914	0.000
M31.3 Wegener's granulomatosis	0.086	0.914	0.000
M86.9 Osteomyelitis, unspecified	0.086	0.914	0.000
M24.19 Other articular cartilage disorders (Site unspecified)	0.086	0.914	0.000
M24.18 Other articular cartilage disorders (Other)	0.086	0.914	0.000
M24.14 Other articular cartilage disorders (Hand)	0.086	0.914	0.000
M24.12 Other articular cartilage disorders (Upper arm)	0.086	0.914	0.000
M24.10 Other articular cartilage disorders (Multiple sites)	0.086	0.914	0.000
M89.3 Hypertrophy of bone	0.086	0.914	0.000
Chapter XXII Codes for special purposes	0.085	0.914	0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure	0.085	0.915	0.000
M90.75 Fracture of bone in neoplastic disease (Pelvic region and thigh)	0.085	0.915	0.000
M84 Disorders of continuity of bone	0.085	0.915	0.000
M31.9 Necrotising vasculopathy, unspecified	0.085	0.915	0.000
M31.8 Other specified necrotising vasculopathies	0.085	0.915	0.000
M31.7 Microscopic polyangiitis	0.085	0.915	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations