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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs7754977
log Bayes Factor = 19.8873
Chromosome 6   position 27,385,770  (GRCh37) Explore rs7754977 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E83.1 Disorders of iron metabolism
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.072 0.928
E10.9 Without complications
0.000 0.076 0.924
E10.5 With peripheral circulatory complications
0.000 0.127 0.873
E10.4 With neurological complications
0.000 0.153 0.847
E10.6 With other specified complications
0.000 0.154 0.846
E10.3 With ophthalmic complications
0.000 0.196 0.804
E10.1 With ketoacidosis
0.000 0.203 0.797
E10.8 With unspecified complications
0.000 0.248 0.752
E10-E14 Diabetes mellitus
0.000 0.273 0.727
E10.2 With renal complications
0.000 0.285 0.715
E10.0 With coma
0.000 0.334 0.666
E10.7 With multiple complications
0.000 0.334 0.666
E13 Other specified diabetes mellitus
0.000 0.398 0.602
E83 Disorders of mineral metabolism
0.000 0.417 0.583
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.433 0.567
E70-E90 Metabolic disorders
0.000 0.440 0.560
E88 Other metabolic disorders
0.000 0.466 0.534
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.467 0.533
E13.9 Without complications
0.000 0.469 0.531
E12 Malnutrition-related diabetes mellitus
0.000 0.479 0.521
E16 Other disorders of pancreatic internal secretion
0.000 0.491 0.509
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.499 0.501
E14 Unspecified diabetes mellitus
0.000 0.504 0.496
E16.2 Hypoglycaemia, unspecified
0.000 0.506 0.494
E14.3 With ophthalmic complications
0.000 0.527 0.473
E40-E46 Malnutrition
0.000 0.534 0.466
E11 Non-insulin-dependent diabetes mellitus
0.000 0.547 0.453
E85 Amyloidosis
0.000 0.556 0.444
E13.8 With unspecified complications
0.000 0.568 0.432
E13.7 With multiple complications
0.000 0.568 0.432
E13.6 With other specified complications
0.000 0.568 0.432
E13.5 With peripheral circulatory complications
0.000 0.568 0.432
E13.4 With neurological complications
0.000 0.568 0.432
E13.2 With renal complications
0.000 0.568 0.432
E13.1 With ketoacidosis
0.000 0.568 0.432
E13.0 With coma
0.000 0.568 0.432
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.582 0.418
E83.8 Other disorders of mineral metabolism
0.000 0.582 0.418
E83.2 Disorders of zinc metabolism
0.000 0.582 0.418
E83.0 Disorders of copper metabolism
0.000 0.582 0.418
E88.2 Lipomatosis, not elsewhere classified
0.000 0.583 0.417
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.585 0.415
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.585 0.414
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.595 0.405
E84 Cystic fibrosis
0.000 0.598 0.401
E77 Disorders of glycoprotein metabolism
0.000 0.598 0.401
E76 Disorders of glycosaminoglycan metabolism
0.000 0.598 0.401
E72 Other disorders of amino-acid metabolism
0.000 0.598 0.401
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.598 0.401
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.598 0.401
E88.3 Tumour lysis syndrome
0.000 0.600 0.400
E46 Unspecified protein-energy malnutrition
0.000 0.606 0.394
E88.8 Other specified metabolic disorders
0.000 0.606 0.394
E13.3 With ophthalmic complications
0.000 0.610 0.390
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.613 0.387
E15 Nondiabetic hypoglycaemic coma
0.000 0.618 0.382
E70 Disorders of aromatic amino-acid metabolism
0.000 0.625 0.375
E12.9 Without complications
0.000 0.626 0.374
E12.8 With unspecified complications
0.000 0.626 0.374
E12.7 With multiple complications
0.000 0.626 0.374
E12.6 With other specified complications
0.000 0.626 0.374
E12.5 With peripheral circulatory complications
0.000 0.626 0.374
E12.4 With neurological complications
0.000 0.626 0.374
E12.3 With ophthalmic complications
0.000 0.626 0.374
E12.2 With renal complications
0.000 0.626 0.374
E12.1 With ketoacidosis
0.000 0.626 0.374
E12.0 With coma
0.000 0.626 0.374
E14.5 With peripheral circulatory complications
0.000 0.628 0.372
E11.0 With coma
0.000 0.630 0.370
E85.9 Amyloidosis, unspecified
0.000 0.633 0.366
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.635 0.365
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.635 0.365
E16.4 Abnormal secretion of gastrin
0.000 0.635 0.365
E16.3 Increased secretion of glucagon
0.000 0.635 0.365
E11.4 With neurological complications
0.000 0.639 0.361
E11.2 With renal complications
0.000 0.644 0.356
E79 Disorders of purine and pyrimidine metabolism
0.000 0.644 0.356
E14.7 With multiple complications
0.000 0.644 0.356
E14.2 Withrenal complications
0.000 0.644 0.356
E14.0 With coma
0.000 0.644 0.356
E88.9 Metabolic disorder, unspecified
0.000 0.645 0.355
E11.1 With ketoacidosis
0.000 0.648 0.352
E11.5 With peripheral circulatory complications
0.000 0.653 0.347
E14.4 With neurological complications
0.000 0.661 0.339
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.665 0.334
E45 Retarded development following protein-energy malnutrition
0.000 0.665 0.334
E43 Unspecified severe protein-energy malnutrition
0.000 0.665 0.334
E42 Marasmic kwashiorkor
0.000 0.665 0.334
E41 Nutritional marasmus
0.000 0.665 0.334
E40 Kwashiorkor
0.000 0.665 0.334
E80.4 Gilbert's syndrome
0.000 0.666 0.334
E14.6 With other specified complications
0.000 0.670 0.330
E11.7 With multiple complications
0.000 0.675 0.325
E85.4 Organ-limited amyloidosis
0.000 0.677 0.323
E14.1 With ketoacidosis
0.000 0.677 0.322
E11.8 With unspecified complications
0.000 0.678 0.322
E85.8 Other amyloidosis
0.000 0.682 0.318
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.682 0.318
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.682 0.318
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.682 0.318
E11.6 With other specified complications
0.000 0.685 0.315
E85.3 Secondary systemic amyloidosis
0.000 0.697 0.303
E73 Lactose intolerance
0.000 0.697 0.303
E74 Other disorders of carbohydrate metabolism
0.000 0.701 0.298
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.702 0.298
E80.5 Crigler-Najjar syndrome
0.000 0.702 0.298
E80.3 Defects of catalase and peroxydase
0.000 0.702 0.298
E80.1 Porphyria cutanea tarda
0.000 0.702 0.298
E80.0 Hereditary erythropoietic porphyria
0.000 0.702 0.298
E65-E68 Obesity and other hyperalimentation
0.000 0.705 0.295
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.711 0.289
E71.3 Disorders of fatty-acid metabolism
0.000 0.712 0.288
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.712 0.288
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.712 0.288
E71.0 Maple-syrup-urine disease
0.000 0.712 0.288
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.712 0.288
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.712 0.288
E72.5 Disorders of glycine metabolism
0.000 0.712 0.288
E72.4 Disorders of ornithine metabolism
0.000 0.712 0.288
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.712 0.288
E72.2 Disorders of urea cycle metabolism
0.000 0.712 0.288
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.712 0.288
E72.0 Disorders of amino-acid transport
0.000 0.712 0.288
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.712 0.288
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.712 0.288
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.712 0.288
E76.2 Other mucopolysaccharidoses
0.000 0.712 0.288
E76.1 Mucopolysaccharidosis, type II
0.000 0.712 0.288
E76.0 Mucopolysaccharidosis, type I
0.000 0.712 0.288
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.712 0.288
E77.8 Other disorders of glycoprotein metabolism
0.000 0.712 0.288
E77.1 Defects in glycoprotein degradation
0.000 0.712 0.288
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.712 0.288
E84.9 Cystic fibrosis, unspecified
0.000 0.712 0.288
E84.8 Cystic fibrosis with other manifestations
0.000 0.712 0.288
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.712 0.288
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.712 0.288
E80.6 Other disorders of bilirubin metabolism
0.000 0.717 0.282
E80.2 Other porphyria
0.000 0.718 0.282
E16.1 Other hypoglycaemia
0.000 0.720 0.280
E75.6 Lipid storage disorder, unspecified
0.000 0.723 0.277
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.723 0.277
E75.3 Sphingolipidosis, unspecified
0.000 0.723 0.277
E75.2 Other sphingolipidosis
0.000 0.723 0.277
E75.1 Other gangliosidosis
0.000 0.723 0.277
E75.0 GM2 gangliosidosis
0.000 0.723 0.277
E83.3 Disorders of phosphorus metabolism
0.000 0.728 0.272
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.731 0.269
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.731 0.269
E70.2 Disorders of tyrosine metabolism
0.000 0.731 0.269
E70.1 Other hyperphenylalaninaemias
0.000 0.731 0.269
E70.0 Classical phenylketonuria
0.000 0.731 0.269
E75.5 Other lipid storage disorders
0.000 0.737 0.262
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.743 0.257
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.744 0.255
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.744 0.255
E79.1 Lesch-Nyhan syndrome
0.000 0.744 0.255
E14.8 With unspecified complications
0.000 0.745 0.255
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.750 0.250
E70.3 Albinism
0.000 0.758 0.242
E44.1 Mild protein-energy malnutrition
0.000 0.760 0.240
E44.0 Moderate protein-energy malnutrition
0.000 0.760 0.240
K90 Intestinal malabsorption
0.000 0.768 0.231
E65 Localised adiposity
0.000 0.773 0.227
E89.4 Postprocedural ovarian failure
0.000 0.775 0.225
E73.8 Other lactose intolerance
0.000 0.783 0.217
E73.1 Secondary lactase deficiency
0.000 0.783 0.217
E73.0 Congenital lactase deficiency
0.000 0.783 0.217
E89.2 Postprocedural hypoparathyroidism
0.000 0.783 0.217
E11.3 With ophthalmic complications
0.000 0.784 0.216
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.786 0.214
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.786 0.214
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.786 0.214
E74.2 Disorders of galactose metabolism
0.000 0.786 0.214
E74.1 Disorders of fructose metabolism
0.000 0.786 0.214
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.786 0.214
E67 Other hyperalimentation
0.000 0.788 0.211
E68 Sequelae of hyperalimentation
0.000 0.788 0.211
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.790 0.210
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.793 0.207
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.793 0.207
E89.5 Postprocedural testicular hypofunction
0.000 0.793 0.207
E89.1 Postprocedural hypoinsulinaemia
0.000 0.793 0.207
E78.2 Mixed hyperlipidaemia
0.000 0.799 0.201
E83.4 Disorders of magnesium metabolism
0.000 0.799 0.200
E87 Other disorders of fluid, electrolyte and acid-base balance
0.000 0.805 0.195
E74.0 Glycogen storage disease
0.000 0.807 0.192
E00-E07 Disorders of thyroid gland
0.000 0.813 0.187
E78.3 Hyperchylomicronaemia
0.000 0.816 0.184
E78.4 Other hyperlipidaemia
0.000 0.816 0.184
E78.1 Pure hyperglyceridaemia
0.000 0.821 0.179
E50-E64 Other nutritional deficiencies
0.000 0.823 0.177
E78.6 Lipoprotein deficiency
0.000 0.825 0.175
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.830 0.170
E87.5 Hyperkalaemia
0.000 0.831 0.169
K90.3 Pancreatic steatorrhoea
0.000 0.834 0.166
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.834 0.166
K90.1 Tropical sprue
0.000 0.834 0.166
E87.0 Hyperosmolality and hypernatraemia
0.000 0.840 0.160
K90.8 Other intestinal malabsorption
0.000 0.842 0.158
E87.3 Alkalosis
0.000 0.843 0.157
E67.8 Other specified hyperalimentation
0.000 0.848 0.152
E67.3 Hypervitaminosis D
0.000 0.848 0.152
E67.2 Megavitamin-B6 syndrome
0.000 0.848 0.152
E67.1 Hypercarotenaemia
0.000 0.848 0.152
E67.0 Hypervitaminosis A
0.000 0.848 0.152
E87.7 Fluid overload
0.000 0.848 0.152
E74.3 Other disorders of intestinal carbohydrate absorption
0.001 0.850 0.149
E89.0 Postprocedural hypothyroidism
0.000 0.852 0.148
E87.4 Mixed disorder of acid-base balance
0.000 0.860 0.140
E06 Thyroiditis
0.000 0.863 0.137
E07 Other disorders of thyroid
0.000 0.866 0.134
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.866 0.134
E00 Congenital iodine-deficiency syndrome
0.000 0.866 0.134
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.872 0.127
E63 Other nutritional deficiencies
0.000 0.872 0.127
E50 Vitamin A deficiency
0.000 0.872 0.127
E60 Dietary zinc deficiency
0.000 0.872 0.127
E59 Dietary selenium deficiency
0.000 0.872 0.127
E54 Ascorbic acid deficiency
0.000 0.872 0.127
E52 Niacin deficiency [pellagra]
0.000 0.872 0.127
E58 Dietary calcium deficiency
0.000 0.874 0.126
E56 Other vitamin deficiencies
0.000 0.877 0.122
E51 Thiamine deficiency
0.000 0.879 0.121
E73.9 Lactose intolerance, unspecified
0.001 0.881 0.118
E20-E35 Disorders of other endocrine glands
0.000 0.883 0.117
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.884 0.116
E83.5 Disorders of calcium metabolism
0.000 0.887 0.113
E53 Deficiency of other B group vitamins
0.000 0.889 0.111
E89.3 Postprocedural hypopituitarism
0.001 0.890 0.110
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.890 0.110
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.000 0.891 0.109
E14.9 Without complications
0.000 0.895 0.105
E03 Other hypothyroidism
0.000 0.896 0.104
E55 Vitamin D deficiency
0.000 0.896 0.104
E07.9 Disorder of thyroid, unspecified
0.000 0.896 0.104
E06.3 Autoimmune thyroiditis
0.000 0.897 0.103
E86 Volume depletion
0.000 0.899 0.101
E06.5 Other chronic thyroiditis
0.000 0.901 0.099
E06.4 Drug-induced thyroiditis
0.000 0.901 0.099
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.901 0.099
E06.1 Subacute thyroiditis
0.000 0.901 0.099
E06.0 Acute thyroiditis
0.000 0.901 0.099
E06.9 Thyroiditis, unspecified
0.000 0.902 0.098
E07.1 Dyshormogenetic goitre
0.000 0.903 0.096
E07.0 Hypersecretion of calcitonin
0.000 0.903 0.096
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.904 0.096
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.904 0.096
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.904 0.096
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.904 0.096
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.904 0.096
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.904 0.096
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.904 0.096
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.904 0.096
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.905 0.095
R31 Unspecified haematuria
0.095 0.905 0.000
E20 Hypoparathyroidism
0.000 0.907 0.093
E87.2 Acidosis
0.000 0.907 0.093
E50.9 Vitamin A deficiency, unspecified
0.000 0.908 0.091
E50.8 Other manifestations of vitamin A deficiency
0.000 0.908 0.091
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.908 0.091
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.908 0.091
E50.5 Vitamin A deficiency with night blindness
0.000 0.908 0.091
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.908 0.091
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.908 0.091
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.908 0.091
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.908 0.091
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.908 0.091
E63.9 Nutritional deficiency, unspecified
0.000 0.908 0.091
E63.8 Other specified nutritional deficiencies
0.000 0.908 0.091
E63.1 Imbalance of constituents of food intake
0.000 0.908 0.091
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.908 0.091
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.908 0.091
E64.8 Sequelae of other nutritional deficiencies
0.000 0.908 0.091
E64.3 Sequelae of rickets
0.000 0.908 0.091
E64.2 Sequelae of vitamin C deficiency
0.000 0.908 0.091
E64.1 Sequelae of vitamin A deficiency
0.000 0.908 0.091
E64.0 Sequelae of protein-energy malnutrition
0.000 0.908 0.091
E04 Other non-toxic goitre
0.000 0.910 0.090
E29 Testicular dysfunction
0.000 0.910 0.089
E05.8 Other thyrotoxicosis
0.000 0.911 0.089
E26 Hyperaldosteronism
0.000 0.911 0.088
E56.9 Vitamin deficiency, unspecified
0.000 0.912 0.088
E56.8 Deficiency of other vitamins
0.000 0.912 0.088
E56.0 Deficiency of vitamin E
0.000 0.912 0.088
E03.8 Other specified hypothyroidism
0.000 0.912 0.088
E07.8 Other specified disorders of thyroid
0.000 0.912 0.087
E51.9 Thiamine deficiency, unspecified
0.000 0.913 0.087
E51.8 Other manifestations of thiamine deficiency
0.000 0.913 0.087
E51.1 Beriberi
0.000 0.913 0.087
E27 Other disorders of adrenal gland
0.000 0.914 0.086
E27.1 Primary adrenocortical insufficiency
0.000 0.915 0.085
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.916 0.084
E32 Diseases of thymus
0.000 0.916 0.084
E31 Polyglandular dysfunction
0.000 0.916 0.084
E30 Disorders of puberty, not elsewhere classified
0.000 0.916 0.084
E25 Adrenogenital disorders
0.000 0.916 0.084
E53.9 Vitamin B deficiency, unspecified
0.000 0.916 0.084
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.916 0.084
E56.1 Deficiency of vitamin K
0.000 0.917 0.083
E05.5 Thyroid crisis or storm
0.000 0.917 0.083
E05.4 Thyrotoxicosis factitia
0.000 0.917 0.083
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.917 0.083
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.917 0.083
E51.2 Wernicke's encephalopathy
0.000 0.919 0.080
E53.1 Pyridoxine deficiency
0.000 0.920 0.080
E53.0 Riboflavin deficiency
0.000 0.920 0.080
E24 Cushing's syndrome
0.000 0.921 0.079
E78.8 Other disorders of lipoprotein metabolism
0.001 0.922 0.078
E34 Other endocrine disorders
0.000 0.922 0.078
E20.9 Hypoparathyroidism, unspecified
0.000 0.924 0.076
E03.5 Myxoedema coma
0.000 0.925 0.075
E03.4 Atrophy of thyroid (acquired)
0.000 0.925 0.075
E03.3 Postinfectious hypothyroidism
0.000 0.925 0.075
E03.1 Congenital hypothyroidism without goitre
0.000 0.925 0.075
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.925 0.075
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.925 0.075
E55.0 Rickets, active
0.000 0.925 0.075
K90.9 Intestinal malabsorption, unspecified
0.000 0.927 0.073
E04.0 Non-toxic diffuse goitre
0.000 0.930 0.070
E29.1 Testicular hypofunction
0.000 0.930 0.070
E26.0 Primary hyperaldosteronism
0.000 0.932 0.068
E28 Ovarian dysfunction
0.000 0.932 0.067
E20.8 Other hypoparathyroidism
0.000 0.933 0.067
E20.1 Pseudohypoparathyroidism
0.000 0.933 0.067
E20.0 Idiopathic hypoparathyroidism
0.000 0.933 0.067
E24.2 Drug-induced Cushing's syndrome
0.000 0.933 0.067
E04.9 Non-toxic goitre, unspecified
0.000 0.934 0.066
E23 Hypofunction and other disorders of pituitary gland
0.000 0.935 0.065
E61 Deficiency of other nutrient elements
0.001 0.935 0.064
E04.8 Other specified non-toxic goitre
0.000 0.935 0.065
E29.9 Testicular dysfunction, unspecified
0.000 0.936 0.064
E29.8 Other testicular dysfunction
0.000 0.936 0.064
E29.0 Testicular hyperfunction
0.000 0.936 0.064
E26.9 Hyperaldosteronism, unspecified
0.000 0.936 0.064
E26.8 Other hyperaldosteronism
0.000 0.936 0.064
E26.1 Secondary hyperaldosteronism
0.000 0.936 0.064
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.936 0.064
M25.55 Pain in joint (Pelvic region and thigh)
0.000 0.937 0.063
E27.5 Adrenomedullary hyperfunction
0.000 0.938 0.062
E27.0 Other adrenocortical overactivity
0.000 0.938 0.062
E25.9 Adrenogenital disorder, unspecified
0.000 0.939 0.060
E25.8 Other adrenogenital disorders
0.000 0.939 0.060
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.939 0.060
E30.9 Disorder of puberty, unspecified
0.000 0.939 0.060
E30.8 Other disorders of puberty
0.000 0.939 0.060
E30.1 Precocious puberty
0.000 0.939 0.060
E30.0 Delayed puberty
0.000 0.939 0.060
E31.9 Polyglandular dysfunction, unspecified
0.000 0.939 0.060
E31.8 Other polyglandular dysfunction
0.000 0.939 0.060
E31.1 Polyglandular hyperfunction
0.000 0.939 0.060
E31.0 Autoimmune polyglandular failure
0.000 0.939 0.060
E32.9 Disease of thymus, unspecified
0.000 0.939 0.060
E32.8 Other diseases of thymus
0.000 0.939 0.060
E32.1 Abscess of thymus
0.000 0.939 0.060
E32.0 Persistent hyperplasia of thymus
0.000 0.939 0.060
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.939 0.060
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.939 0.060
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.939 0.060
E24.8 Other Cushing's syndrome
0.000 0.943 0.057
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.943 0.057
E24.3 Ectopic ACTH syndrome
0.000 0.943 0.057
E24.1 Nelson's syndrome
0.000 0.943 0.057
E53.8 Deficiency of other specified B group vitamins
0.000 0.944 0.056
E34.5 Androgen resistance syndrome
0.000 0.944 0.056
E34.4 Constitutional tall stature
0.000 0.944 0.056
E34.3 Short stature, not elsewhere classified
0.000 0.944 0.056
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.944 0.056
E34.1 Other hypersecretion of intestinal hormones
0.000 0.944 0.056
E23.2 Diabetes insipidus
0.000 0.944 0.056
E34.0 Carcinoid syndrome
0.000 0.945 0.055
E66 Obesity
0.000 0.945 0.055
E34.9 Endocrine disorder, unspecified
0.000 0.945 0.054
E34.8 Other specified endocrine disorders
0.000 0.948 0.052
E24.0 Pituitary-dependent Cushing's disease
0.000 0.948 0.052
E55.9 Vitamin D deficiency, unspecified
0.000 0.948 0.051
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.949 0.051
E28.2 Polycystic ovarian syndrome
0.000 0.950 0.050
M25.57 Pain in joint (Ankle and foot)
0.000 0.951 0.049
E27.2 Addisonian crisis
0.000 0.951 0.049
E28.9 Ovarian dysfunction, unspecified
0.000 0.951 0.048
E28.8 Other ovarian dysfunction
0.000 0.951 0.048
E28.1 Androgen excess
0.000 0.951 0.048
E28.0 Oestrogen excess
0.000 0.951 0.048
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.953 0.047
E23.1 Drug-induced hypopituitarism
0.000 0.953 0.047
E61.9 Deficiency of nutrient element, unspecified
0.001 0.953 0.046
E61.8 Deficiency of other specified nutrient elements
0.001 0.953 0.046
E61.7 Deficiency of multiple nutrient elements
0.001 0.953 0.046
E61.6 Vanadium deficiency
0.001 0.953 0.046
E61.5 Molybdenum deficiency
0.001 0.953 0.046
E61.4 Chromium deficiency
0.001 0.953 0.046
E61.3 Manganese deficiency
0.001 0.953 0.046
E61.0 Copper deficiency
0.001 0.953 0.046
M25.5 Pain in joint
0.000 0.954 0.046
E23.7 Disorder of pituitary gland, unspecified
0.000 0.957 0.043
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.958 0.042
E04.2 Non-toxic multinodular goitre
0.000 0.958 0.042
E24.9 Cushing's syndrome, unspecified
0.000 0.959 0.041
E04.1 Non-toxic single thyroid nodule
0.000 0.959 0.040
E27.8 Other specified disorders of adrenal gland
0.000 0.960 0.040
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.960 0.040
E23.6 Other disorders of pituitary gland
0.000 0.960 0.040
E66.1 Drug-induced obesity
0.000 0.961 0.039
M25.58 Pain in joint (Other)
0.000 0.961 0.039
M25.52 Pain in joint (Upper arm)
0.000 0.963 0.037
E61.2 Magnesium deficiency
0.001 0.964 0.035
E66.0 Obesity due to excess calories
0.000 0.965 0.035
M25.51 Pain in joint (Shoulder region)
0.000 0.965 0.035
E27.9 Disorder of adrenal gland, unspecified
0.001 0.967 0.032
E87.6 Hypokalaemia
0.000 0.968 0.032
M25.54 Pain in joint (Hand)
0.000 0.968 0.032
M25.53 Pain in joint (Forearm)
0.000 0.969 0.031
E21.4 Other specified disorders of parathyroid gland
0.000 0.970 0.030
E21.2 Other hyperparathyroidism
0.000 0.970 0.030
E21.3 Hyperparathyroidism, unspecified
0.000 0.971 0.029
E28.3 Primary ovarian failure
0.001 0.971 0.029
E22 Hyperfunction of pituitary gland
0.000 0.971 0.028
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.973 0.027
E11.9 Without complications
0.000 0.976 0.024
E21.0 Primary hyperparathyroidism
0.000 0.979 0.021
E23.0 Hypopituitarism
0.000 0.979 0.021
E22.8 Other hyperfunction of pituitary gland
0.000 0.979 0.020
M25.59 Pain in joint (Site unspecified)
0.000 0.980 0.020
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.980 0.020
E22.9 Hyperfunction of pituitary gland, unspecified
0.001 0.982 0.017
E22.1 Hyperprolactinaemia
0.000 0.983 0.017
K90-K93 Other diseases of the digestive system
0.000 0.985 0.015
E61.1 Iron deficiency
0.002 0.985 0.013
E05.9 Thyrotoxicosis, unspecified
0.000 0.986 0.014
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.987 0.013
G31.8 Other specified degenerative diseases of nervous system
0.000 0.987 0.013
M25.50 Pain in joint (Multiple sites)
0.000 0.987 0.013
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.000 0.987 0.013
E22.0 Acromegaly and pituitary gigantism
0.001 0.988 0.012
G31.9 Degenerative disease of nervous system, unspecified
0.000 0.988 0.012
G31.0 Circumscribed brain atrophy
0.000 0.988 0.012
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.989 0.011
E66.9 Obesity, unspecified
0.000 0.989 0.011
G30-G32 Other degenerative diseases of the nervous system
0.000 0.990 0.010
G30 Alzheimer's disease
0.000 0.990 0.010
G31.1 Senile degeneration of brain, not elsewhere classified
0.000 0.990 0.009
G30.0 Alzheimer's disease with early onset
0.000 0.991 0.009
G30.9 Alzheimer's disease, unspecified
0.000 0.991 0.009
G44.2 Tension-type headache
0.008 0.992 0.000
K93.8 Disorders of other specified digestive organs in diseases classified elsewhere
0.000 0.992 0.008
K93.1 Megacolon in Chagas' disease
0.000 0.992 0.008
K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands
0.000 0.992 0.008
G31.2 Degeneration of nervous system due to alcohol
0.000 0.992 0.008
E78.5 Hyperlipidaemia, unspecified
0.000 0.992 0.008
G30.8 Other Alzheimer's disease
0.000 0.992 0.008
G30.1 Alzheimer's disease with late onset
0.000 0.993 0.007
G32 Other degenerative disorders of nervous system in diseases classified elsewhere
0.000 0.993 0.007
K56.4 Other impaction of intestine
0.006 0.994 0.000
G54.9 Nerve root and plexus disorder, unspecified
0.006 0.994 0.000
E87.1 Hypo-osmolality and hyponatraemia
0.000 0.994 0.006
Z34.9 Supervision of normal pregnancy, unspecified
0.006 0.994 0.000
G32.0 Subacute combined degeneration of spinal cord in diseases classified elsewhere
0.000 0.995 0.005
M41.97 Scoliosis, unspecified (Lumbosacral region)
0.005 0.995 0.000
M41.9 Scoliosis, unspecified
0.005 0.995 0.000
G32.8 Other specified degenerative disorders of nervous system in diseases classified elsewhere
0.000 0.995 0.005
K22.8 Other specified diseases of oesophagus
0.005 0.995 0.000
R30.0 Dysuria
0.005 0.995 0.000
M41.99 Scoliosis, unspecified (Site unspecified)
0.005 0.995 0.000
M25.56 Pain in joint (Lower leg)
0.000 0.995 0.005
M41.96 Scoliosis, unspecified (Lumbar region)
0.005 0.995 0.000
M67.8 Other specified disorders of synovium and tendon
0.000 0.995 0.005
G82.5 Tetraplegia, unspecified
0.000 0.995 0.005
M41.94 Scoliosis, unspecified (Thoracic region)
0.005 0.995 0.000
G44 Other headache syndromes
0.004 0.996 0.000
G95.8 Other specified diseases of spinal cord
0.000 0.996 0.004
N60.1 Diffuse cystic mastopathy
0.000 0.996 0.004
R30 Pain associated with micturition
0.004 0.996 0.000
M41.95 Scoliosis, unspecified (Thoracolumbar region)
0.004 0.996 0.000
M96.8 Other postprocedural musculoskeletal disorders
0.000 0.996 0.004
G82 Paraplegia and tetraplegia
0.000 0.996 0.004
G82.4 Spastic tetraplegia
0.000 0.996 0.004
M41.98 Scoliosis, unspecified (Sacral and sacrococcygeal region)
0.004 0.996 0.000
M41.93 Scoliosis, unspecified (Cervicothoracic region)
0.004 0.996 0.000
M41.92 Scoliosis, unspecified (Cervical region)
0.004 0.996 0.000
M41.91 Scoliosis, unspecified (Occipito-atlanto-axial region)
0.004 0.996 0.000
G44.8 Other specified headache syndromes
0.004 0.996 0.000
N04.9 Unspecified
0.000 0.996 0.004
G82.1 Spastic paraplegia
0.000 0.996 0.004
R30.1 Vesical tenesmus
0.004 0.996 0.000
R30-R39 Symptoms and signs involving the urinary system
0.004 0.996 0.000
K02.9 Dental caries, unspecified
0.000 0.996 0.004
M96 Postprocedural musculoskeletal disorders, not elsewhere classified
0.000 0.996 0.004
M96.1 Postlaminectomy syndrome, not elsewhere classified
0.000 0.996 0.004
G71.1 Myotonic disorders
0.000 0.996 0.004
K56 Paralytic ileus and intestinal obstruction without hernia
0.004 0.996 0.000
E66.8 Other obesity
0.000 0.996 0.004
M96.0 Pseudarthrosis after fusion or arthrodesis
0.000 0.996 0.004
M41.90 Scoliosis, unspecified (Multiple sites in spine)
0.003 0.996 0.000
K56.5 Intestinal adhesions [bands] with obstruction
0.004 0.996 0.000
M25.74 Osteophyte (Hand)
0.000 0.996 0.003
G44.1 Vascular headache, not elsewhere classified
0.003 0.997 0.000
K56.2 Volvulus
0.003 0.997 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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