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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs7775228
log Bayes Factor = 52.346
Chromosome 6   position 32,658,079  (GRCh37) Explore rs7775228 on Ensembl!
Variant rs7775228 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
M35.3 Polymyalgia rheumatica
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
M05-M14 Inflammatory polyarthropathies
0.000 0.000 1.000
Chapter VII Diseases of the eye and adnexa
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
# Top node
0.000 0.000 1.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
M35 Other systemic involvement of connective tissue
0.000 0.000 1.000
M05 Seropositive rheumatoid arthritis
0.000 0.000 1.000
K90.0 Coeliac disease
1.000 0.000 0.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
H36.0 Diabetic retinopathy
0.000 0.001 0.999
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.001 0.999
E10.3 With ophthalmic complications
0.000 0.001 0.999
H36 Retinal disorders in diseases classified elsewhere
0.000 0.001 0.999
M20-M25 Other joint disorders
0.000 0.001 0.999
H30-H36 Disorders of choroid and retina
0.000 0.001 0.999
Chapter X Diseases of the respiratory system
0.000 0.002 0.998
H04 Disorders of lachrymal system
0.000 0.003 0.997
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.005 0.995
E10.1 With ketoacidosis
0.000 0.005 0.995
E05.9 Thyrotoxicosis, unspecified
0.000 0.006 0.994
H02 Other disorders of eyelid
0.000 0.007 0.993
J80-J84 Other respiratory diseases principally affecting the interstitium
0.000 0.010 0.990
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.011 0.989
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.013 0.987
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.015 0.985
Chapter V Mental and behavioural disorders
0.000 0.016 0.984
E20-E35 Disorders of other endocrine glands
0.000 0.018 0.982
F30-F39 Mood [affective] disorders
0.000 0.019 0.981
H04.5 Stenosis and insufficiency of lachrymal passages
0.000 0.020 0.980
H02.0 Entropion and trichiasis of eyelid
0.000 0.020 0.980
L20-L30 Dermatitis and eczema
0.000 0.024 0.976
J20-J22 Other acute lower respiratory infections
0.000 0.024 0.976
E27 Other disorders of adrenal gland
0.000 0.025 0.975
J84 Other interstitial pulmonary diseases
0.000 0.029 0.971
F31 Bipolar affective disorder
0.000 0.030 0.970
J00-J06 Acute upper respiratory infections
0.000 0.033 0.967
E27.1 Primary adrenocortical insufficiency
0.000 0.034 0.966
J95-J99 Other diseases of the respiratory system
0.000 0.043 0.957
J22 Unspecified acute lower respiratory infection
0.000 0.046 0.954
H02.1 Ectropion of eyelid
0.000 0.050 0.950
J00 Acute nasopharyngitis [common cold]
0.000 0.054 0.946
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.062 0.938
L30 Other dermatitis
0.000 0.067 0.933
H04.2 Epiphora
0.000 0.068 0.932
F32 Depressive episode
0.000 0.068 0.932
M06.0 Seronegative rheumatoid arthritis
0.000 0.074 0.926
H53-H54 Visual disturbances and blindness
0.000 0.077 0.923
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.079 0.921
E11 Non-insulin-dependent diabetes mellitus
0.000 0.082 0.918
J84.1 Other interstitial pulmonary diseases with fibrosis
0.000 0.082 0.918
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.085 0.915
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.086 0.913
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.089 0.911
J98 Other respiratory disorders
0.000 0.097 0.903
E11.3 With ophthalmic complications
0.000 0.097 0.903
E10.2 With renal complications
0.000 0.098 0.902
E10.5 With peripheral circulatory complications
0.000 0.099 0.901
L30.9 Dermatitis, unspecified
0.000 0.101 0.899
F32.2 Severe depressive episode without psychotic symptoms
0.000 0.101 0.899
F31.9 Bipolar affective disorder, unspecified
0.000 0.101 0.899
E28 Ovarian dysfunction
0.000 0.102 0.898
H53 Visual disturbances
0.000 0.104 0.896
E10.4 With neurological complications
0.000 0.105 0.895
E16 Other disorders of pancreatic internal secretion
0.000 0.107 0.893
F32.1 Moderate depressive episode
0.000 0.109 0.891
H55-H59 Other disorders of eye and adnexa
0.000 0.113 0.887
J84.9 Interstitial pulmonary disease, unspecified
0.000 0.114 0.886
Chapter I Certain infectious and parasitic diseases
0.000 0.115 0.885
M34 Systemic sclerosis
0.000 0.115 0.885
J80 Adult respiratory distress syndrome
0.000 0.116 0.884
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.000 0.117 0.883
L00-L08 Infections of the skin and subcutaneous tissue
0.000 0.119 0.881
M35.0 Sicca syndrome [Sjogren]
0.000 0.126 0.874
E16.2 Hypoglycaemia, unspecified
0.000 0.127 0.873
F31.1 Bipolar affective disorder, current episode manic without psychotic symptoms
0.000 0.128 0.872
E70-E90 Metabolic disorders
0.000 0.129 0.871
H53.9 Visual disturbance, unspecified
0.000 0.130 0.870
M06.3 Rheumatoid nodule
0.000 0.132 0.868
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.133 0.867
H05 Disorders of orbit
0.000 0.144 0.856
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.145 0.855
L02 Cutaneous abscess, furuncle and carbuncle
0.000 0.145 0.855
J98.4 Other disorders of lung
0.000 0.147 0.853
M35.1 Other overlap syndromes
0.000 0.147 0.853
B35-B49 Mycoses
0.000 0.151 0.849
J95 Postprocedural respiratory disorders, not elsewhere classified
0.000 0.155 0.845
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.156 0.844
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.000 0.157 0.843
M21 Other acquired deformities of limbs
0.000 0.159 0.841
B37 Candidiasis
0.000 0.159 0.841
L29 Pruritus
0.000 0.162 0.838
H53.0 Amblyopia ex anopsia
0.000 0.163 0.837
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.164 0.836
L02.2 Cutaneous abscess, furuncle and carbuncle of trunk
0.000 0.167 0.833
H04.8 Other disorders of lachrymal system
0.000 0.168 0.832
B37.8 Candidiasis of other sites
0.000 0.170 0.830
A50-A64 Infections with a predominantly sexual mode of transmission
0.000 0.172 0.828
H02.9 Disorder of eyelid, unspecified
0.000 0.176 0.824
L21 Seborrhoeic dermatitis
0.000 0.176 0.824
M60-M63 Disorders of muscles
0.000 0.178 0.822
F31.4 Bipolar affective disorder, current episode severe depression without psychotic symptoms
0.000 0.178 0.822
M31 Other necrotising vasculopathies
0.000 0.181 0.819
J04 Acute laryngitis and tracheitis
0.000 0.181 0.819
D68 Other coagulation defects
0.000 0.181 0.819
E27.8 Other specified disorders of adrenal gland
0.000 0.184 0.816
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.186 0.814
E20 Hypoparathyroidism
0.000 0.188 0.812
M07 Psoriatic and enteropathic arthropathies
0.000 0.188 0.812
L02.4 Cutaneous abscess, furuncle and carbuncle of limb
0.000 0.188 0.812
M06.4 Inflammatory polyarthropathy
0.000 0.189 0.811
M21.0 Valgus deformity, not elsewhere classified
0.000 0.193 0.807
E28.2 Polycystic ovarian syndrome
0.000 0.198 0.802
L80-L99 Other disorders of the skin and subcutaneous tissue
0.000 0.199 0.801
L57 Skin changes due to chronic exposure to nonionising radiation
0.000 0.200 0.800
F31.3 Bipolar affective disorder, current episode mild or moderate depression
0.000 0.200 0.800
E10.0 With coma
0.000 0.201 0.799
E11.1 With ketoacidosis
0.000 0.203 0.797
F31.0 Bipolar affective disorder, current episode hypomanic
0.000 0.203 0.797
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.207 0.793
E10.8 With unspecified complications
0.000 0.208 0.792
H55 Nystagmus and other irregular eye movements
0.000 0.212 0.788
A63 Other predominantly sexually transmitted diseases, not elsewhere classified
0.000 0.214 0.786
H04.3 Acute and unspecified inflammation of lachrymal passages
0.000 0.216 0.784
H57 Other disorders of eye and adnexa
0.000 0.220 0.780
E89.0 Postprocedural hypothyroidism
0.000 0.222 0.778
B37.0 Candidal stomatitis
0.000 0.223 0.777
F00-F09 Organic, including symptomatic, mental disorders
0.000 0.224 0.776
M32 Systemic lupus erythematosus
0.000 0.226 0.774
L98 Other disorders of skin and subcutaneous tissue, not elsewhere classified
0.000 0.227 0.773
M06.34 Rheumatoid nodule (Hand)
0.000 0.227 0.773
D60-D64 Aplastic and other anaemias
0.000 0.228 0.772
J20 Acute bronchitis
0.000 0.228 0.772
F30 Manic episode
0.000 0.229 0.771
M21.06 Valgus deformity, not elsewhere classified (Lower leg)
0.000 0.230 0.770
H02.6 Xanthelasma of eyelid
0.000 0.231 0.769
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.231 0.769
J95.0 Tracheostomy malfunction
0.000 0.234 0.766
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.000 0.234 0.766
D68.5 Primary Thrombophilia
0.000 0.234 0.766
F20 Schizophrenia
0.000 0.238 0.762
J82 Pulmonary eosinophilia, not elsewhere classified
0.000 0.238 0.761
L30.8 Other specified dermatitis
0.000 0.239 0.761
E06 Thyroiditis
0.000 0.240 0.760
E50-E64 Other nutritional deficiencies
0.000 0.240 0.760
L20 Atopic dermatitis
0.000 0.241 0.759
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.241 0.759
L29.0 Pruritus ani
0.000 0.242 0.758
E27.9 Disorder of adrenal gland, unspecified
0.000 0.243 0.757
M34.9 Systemic sclerosis, unspecified
0.000 0.244 0.756
A63.0 Anogenital (venereal) warts
0.000 0.245 0.755
E10.6 With other specified complications
0.000 0.246 0.754
D50-D53 Nutritional anaemias
0.000 0.247 0.753
J02 Acute pharyngitis
0.000 0.248 0.752
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.248 0.751
E29 Testicular dysfunction
0.000 0.248 0.751
J04.0 Acute laryngitis
0.000 0.250 0.750
L81 Other disorders of pigmentation
0.000 0.252 0.748
N48 Other disorders of penis
0.745 0.255 0.000
J84.8 Other specified interstitial pulmonary diseases
0.000 0.256 0.744
J01 Acute sinusitis
0.000 0.258 0.742
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.259 0.741
J81 Pulmonary oedema
0.000 0.261 0.739
F39 Unspecified mood [affective] disorder
0.000 0.262 0.738
L57.8 Other skin changes due to chronic exposure to nonionising radiation
0.000 0.262 0.738
E28.3 Primary ovarian failure
0.000 0.262 0.738
N48.6 Balanitis xerotica obliterans
0.736 0.264 0.000
F22 Persistent delusional disorders
0.000 0.264 0.736
M86-M90 Other osteopathies
0.000 0.265 0.735
H30 Chorioretinal inflammation
0.000 0.266 0.734
F34 Persistent mood [affective] disorders
0.000 0.267 0.733
J98.1 Pulmonary collapse
0.000 0.267 0.733
L25 Unspecified contact dermatitis
0.000 0.268 0.732
E23 Hypofunction and other disorders of pituitary gland
0.000 0.269 0.731
H06.2 Dysthyroid exophthalmos
0.000 0.269 0.731
L28 Lichen simplex chronicus and prurigo
0.000 0.269 0.730
L98.0 Pyogenic granuloma
0.000 0.270 0.730
E27.2 Addisonian crisis
0.000 0.272 0.728
H05.2 Exophthalmic conditions
0.000 0.273 0.727
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.000 0.273 0.727
H05.0 Acute inflammation of orbit
0.000 0.278 0.722
M31.3 Wegener's granulomatosis
0.000 0.278 0.722
H04.9 Disorder of lachrymal system, unspecified
0.000 0.278 0.722
E11.2 With renal complications
0.000 0.281 0.719
J98.5 Diseases of mediastinum, not elsewhere classified
0.000 0.281 0.719
H01 Other inflammation of eyelid
0.000 0.281 0.719
H02.8 Other specified disorders of eyelid
0.000 0.282 0.718
E10.7 With multiple complications
0.000 0.283 0.717
M06.8 Other specified rheumatoid arthritis
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M06.1 Adult-onset Still's disease
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.283 0.717
M12 Other specific arthropathies
0.000 0.283 0.717
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.283 0.717
M08 Juvenile arthritis
0.000 0.283 0.717
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.1 Congenital hypothyroidism without goitre
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
N48.8 Other specified disorders of penis
0.717 0.283 0.000
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.283 0.717
M35.8 Other specified systemic involvement of connective tissue
0.000 0.283 0.717
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.283 0.717
M35.5 Multifocal fibrosclerosis
0.000 0.283 0.717
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.283 0.717
M35.2 Behcet's disease
0.000 0.283 0.717
M05.8 Other seropositive rheumatoid arthritis
0.000 0.283 0.717
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.283 0.717
M05.2 Rheumatoid vasculitis
0.000 0.283 0.717
M05.1 Rheumatoid lung disease
0.000 0.283 0.717
M05.0 Felty's syndrome
0.000 0.283 0.717
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.283 0.717
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.283 0.717
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.283 0.717
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.283 0.717
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.283 0.717
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.283 0.717
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
L27 Dermatitis due to substances taken internally
0.000 0.283 0.717
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.284 0.716
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.284 0.716
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.000 0.284 0.716
J21 Acute bronchiolitis
0.000 0.284 0.716
H04.6 Other changes in lachrymal passages
0.000 0.285 0.715
H04.0 Dacryoadenitis
0.000 0.285 0.715
J98.0 Diseases of bronchus, not elsewhere classified
0.000 0.286 0.714
L21.9 Seborrhoeic dermatitis, unspecified
0.000 0.286 0.714
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.287 0.713
H02.7 Other degenerative disorders of eyelid and periocular area
0.000 0.288 0.712
L81.4 Other melanin hyperpigmentation
0.000 0.289 0.711
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.289 0.711
M30 Polyarteritis nodosa and related conditions
0.000 0.290 0.710
L23 Allergic contact dermatitis
0.000 0.290 0.710
H04.1 Other disorders of lachrymal gland
0.000 0.292 0.708
D69 Purpura and other haemorrhagic conditions
0.000 0.292 0.708
M24 Other specific joint derangements
0.000 0.293 0.707
M62 Other disorders of muscle
0.000 0.294 0.706
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.000 0.294 0.706
H04.4 Chronic inflammation of lachrymal passages
0.000 0.295 0.705
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.296 0.704
E32 Diseases of thymus
0.000 0.296 0.704
E31 Polyglandular dysfunction
0.000 0.296 0.704
E30 Disorders of puberty, not elsewhere classified
0.000 0.296 0.704
F38 Other mood [affective] disorders
0.000 0.296 0.703
N40-N51 Diseases of male genital organs
0.702 0.298 0.000
H10-H13 Disorders of conjunctiva
0.000 0.299 0.701
L24 Irritant contact dermatitis
0.000 0.300 0.700
L26 Exfoliative dermatitis
0.000 0.300 0.700
L22 Diaper [napkin] dermatitis
0.000 0.300 0.700
D62 Acute posthaemorrhagic anaemia
0.000 0.300 0.700
E27.5 Adrenomedullary hyperfunction
0.000 0.301 0.699
E27.0 Other adrenocortical overactivity
0.000 0.301 0.699
M35.7 Hypermobility syndrome
0.000 0.301 0.699
M80-M85 Disorders of bone density and structure
0.000 0.302 0.698
E88 Other metabolic disorders
0.000 0.303 0.697
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.304 0.696
J84.0 Alveolar and parietoalveolar conditions
0.000 0.304 0.696
F23 Acute and transient psychotic disorders
0.000 0.304 0.696
F31.8 Other bipolar affective disorders
0.000 0.304 0.695
F31.7 Bipolar affective disorder, currently in remission
0.000 0.304 0.695
F31.5 Bipolar affective disorder, current episode severe depression with psychotic symptoms
0.000 0.304 0.695
L98.4 Chronic ulcer of skin, not elsewhere classified
0.000 0.307 0.693
M34.1 CR(E)ST syndrome
0.000 0.308 0.692
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.308 0.691
E20.9 Hypoparathyroidism, unspecified
0.000 0.309 0.691
E05.8 Other thyrotoxicosis
0.000 0.311 0.689
M65-M68 Disorders of synovium and tendon
0.000 0.312 0.688
D61 Other aplastic anaemias
0.000 0.312 0.688
H57.0 Anomalies of pupillary function
0.000 0.313 0.687
J96 Respiratory failure, not elsewhere classified
0.000 0.313 0.686
F32.3 Severe depressive episode with psychotic symptoms
0.000 0.314 0.686
F80-F89 Disorders of psychological development
0.000 0.314 0.686
H02.2 Lagophthalmos
0.000 0.317 0.683
L98.8 Other specified disorders of skin and subcutaneous tissue
0.000 0.318 0.682
F70-F79 Mental retardation
0.000 0.318 0.682
E03.8 Other specified hypothyroidism
0.000 0.319 0.681
E73 Lactose intolerance
0.000 0.319 0.681
B37.1 Pulmonary candidiasis
0.000 0.320 0.680
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.320 0.680
H46-H48 Disorders of optic nerve and visual pathways
0.000 0.322 0.678
H53.4 Visual field defects
0.000 0.322 0.678
M07.3 Other psoriatic arthropathies
0.000 0.322 0.677
M34.8 Other forms of systemic sclerosis
0.000 0.323 0.677
D68.9 Coagulation defect, unspecified
0.000 0.325 0.675
J98.9 Respiratory disorder, unspecified
0.000 0.327 0.673
E15 Nondiabetic hypoglycaemic coma
0.000 0.328 0.672
F20.0 Paranoid schizophrenia
0.000 0.328 0.672
N48.0 Leukoplakia of penis
0.671 0.329 0.000
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.330 0.670
M80 Osteoporosis with pathological fracture
0.000 0.330 0.670
B90-B94 Sequelae of infectious and parasitic diseases
0.000 0.331 0.669
L30.5 Pityriasis alba
0.000 0.331 0.669
L30.4 Erythema intertrigo
0.000 0.331 0.669
L30.2 Cutaneous autosensitisation
0.000 0.331 0.669
L30.1 Dyshidrosis [pompholyx]
0.000 0.331 0.669
L30.0 Nummular dermatitis
0.000 0.331 0.669
B07 Viral warts
0.000 0.331 0.669
L97 Ulcer of lower limb, not elsewhere classified
0.000 0.332 0.668
M00-M03 Infectious arthropathies
0.000 0.334 0.666
N47 Redundant prepuce, phimosis and paraphimosis
0.666 0.334 0.000
M11 Other crystal arthropathies
0.000 0.335 0.665
D68.0 Von Willebrand's disease
0.000 0.335 0.665
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.336 0.664
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.336 0.664
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.336 0.664
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.336 0.664
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.336 0.664
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.336 0.664
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.336 0.664
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.336 0.664
E26 Hyperaldosteronism
0.000 0.338 0.662
H18 Other disorders of cornea
0.000 0.338 0.662
L05 Pilonidal cyst
0.000 0.339 0.661
F40-F48 Neurotic, stress-related and somatoform disorders
0.000 0.339 0.661
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.340 0.660
M62.8 Other specified disorders of muscle
0.000 0.342 0.658
E11.7 With multiple complications
0.000 0.342 0.658
L57.0 Actinic keratosis
0.000 0.344 0.656
D80-D89 Certain disorders involving the immune mechanism
0.000 0.344 0.655
M21.07 Valgus deformity, not elsewhere classified (Ankle and foot)
0.000 0.346 0.654
M89 Other disorders of bone
0.000 0.346 0.654
H16 Keratitis
0.000 0.349 0.651
F31.2 Bipolar affective disorder, current episode manic with psychotic symptoms
0.000 0.349 0.651
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.349 0.651
B37.9 Candidiasis, unspecified
0.000 0.349 0.651
M14 Arthropathies in other diseases classified elsewhere
0.000 0.349 0.650
D68.8 Other specified coagulation defects
0.000 0.349 0.651
F32.8 Other depressive episodes
0.000 0.350 0.649
J95.8 Other postprocedural respiratory disorders
0.000 0.352 0.648
J98.3 Compensatory emphysema
0.000 0.352 0.647
J98.2 Interstitial emphysema
0.000 0.352 0.647
M80.9 Unspecified osteoporosis with pathological fracture
0.000 0.352 0.647
L93 Lupus erythematosus
0.000 0.353 0.647
E28.9 Ovarian dysfunction, unspecified
0.000 0.356 0.644
E28.8 Other ovarian dysfunction
0.000 0.356 0.644
E28.1 Androgen excess
0.000 0.356 0.644
E28.0 Oestrogen excess
0.000 0.356 0.644
F01 Vascular dementia
0.000 0.357 0.643
H53.6 Night blindness
0.000 0.357 0.643
H53.5 Colour vision deficiencies
0.000 0.357 0.643
H53.3 Other disorders of binocular vision
0.000 0.357 0.643
F05 Delirium, not induced by alcohol and other psychoactive substances
0.000 0.359 0.641
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.360 0.640
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.360 0.640
E16.4 Abnormal secretion of gastrin
0.000 0.360 0.640
E16.3 Increased secretion of glucagon
0.000 0.360 0.640
B25-B34 Other viral diseases
0.000 0.361 0.639
J20.9 Acute bronchitis, unspecified
0.000 0.362 0.638
A30-A49 Other bacterial diseases
0.000 0.362 0.638
L29.2 Pruritus vulvae
0.000 0.363 0.637
D61.9 Aplastic anaemia, unspecified
0.000 0.364 0.636
H03 Disorders of eyelid in diseases classified elsewhere
0.000 0.364 0.636
A65-A69 Other spirochaetal diseases
0.000 0.364 0.636
E86 Volume depletion
0.000 0.364 0.636
B85-B89 Pediculosis, acariasis and other infestations
0.000 0.365 0.635
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.000 0.365 0.635
A75-A79 Rickettsioses
0.000 0.365 0.635
A70-A74 Other diseases caused by chlamydiae
0.000 0.365 0.635
A20-A28 Certain zoonotic bacterial diseases
0.000 0.365 0.635
M34.2 Systemic sclerosis induced by drugs and chemicals
0.000 0.366 0.634
M34.0 Progressive systemic sclerosis
0.000 0.366 0.634
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.366 0.634
F28 Other nonorganic psychotic disorders
0.000 0.367 0.633
F24 Induced delusional disorder
0.000 0.367 0.633
F21 Schizotypal disorder
0.000 0.367 0.633
M31.5 Giant cell arteritis with polymyalgia rheumatica
0.000 0.368 0.632
L80 Vitiligo
0.000 0.368 0.632
L01 Impetigo
0.000 0.369 0.631
L00 Staphylococcal scalded skin syndrome
0.000 0.369 0.631
F22.0 Delusional disorder
0.000 0.369 0.631
J05 Acute obstructive laryngitis [croup] and epiglottitis
0.000 0.372 0.628
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.000 0.372 0.627
L56 Other acute skin changes due to ultraviolet radiation
0.000 0.374 0.626
H58 Other disorders of eye and adnexa in diseases classified elsewhere
0.000 0.375 0.625
E84 Cystic fibrosis
0.000 0.376 0.624
E79 Disorders of purine and pyrimidine metabolism
0.000 0.376 0.624
E77 Disorders of glycoprotein metabolism
0.000 0.376 0.624
E76 Disorders of glycosaminoglycan metabolism
0.000 0.376 0.624
E72 Other disorders of amino-acid metabolism
0.000 0.376 0.624
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.376 0.624
E70 Disorders of aromatic amino-acid metabolism
0.000 0.376 0.624
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.376 0.624
M40-M43 Deforming dorsopathies
0.000 0.376 0.624
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.376 0.624
B15-B19 Viral hepatitis
0.000 0.376 0.624
E11.8 With unspecified complications
0.000 0.377 0.623
E11.4 With neurological complications
0.000 0.378 0.622
E07 Other disorders of thyroid
0.000 0.378 0.622
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.378 0.622
M06.38 Rheumatoid nodule (Other)
0.000 0.378 0.622
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.378 0.622
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.378 0.622
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.378 0.622
M06.33 Rheumatoid nodule (Forearm)
0.000 0.378 0.622
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.378 0.622
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.378 0.622
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.378 0.622
L58 Radiodermatitis
0.000 0.378 0.622
L55 Sunburn
0.000 0.378 0.622
E25 Adrenogenital disorders
0.000 0.378 0.621
N48.9 Disorder of penis, unspecified
0.621 0.379 0.000
D68.6 Other Thrombophilia
0.000 0.380 0.620
N49 Inflammatory disorders of male genital organs, not elsewhere classified
0.620 0.380 0.000
H34 Retinal vascular occlusions
0.000 0.380 0.620
B20-B24 Human immunodeficiency virus [HIV] disease
0.000 0.380 0.620
M62.80 Other specified disorders of muscle (Multiple sites)
0.000 0.380 0.620
J06 Acute upper respiratory infections of multiple and unspecified sites
0.000 0.381 0.618
N50 Other disorders of male genital organs
0.618 0.382 0.000
H35 Other retinal disorders
0.000 0.383 0.617
F31.6 Bipolar affective disorder, current episode mixed
0.000 0.384 0.616
L83 Acanthosis nigricans
0.000 0.385 0.615
F25 Schizoaffective disorders
0.000 0.386 0.614
H05.9 Disorder of orbit, unspecified
0.000 0.386 0.614
H05.5 Retained (old) foreign body following penetrating wound of orbit
0.000 0.386 0.614
H05.3 Deformity of orbit
0.000 0.386 0.614
H05.1 Chronic inflammatory disorders of orbit
0.000 0.386 0.614
L08 Other local infections of skin and subcutaneous tissue
0.000 0.387 0.613
M21.7 Unequal limb length (acquired)
0.000 0.387 0.613
D67 Hereditary factor IX deficiency
0.000 0.387 0.613
L02.8 Cutaneous abscess, furuncle and carbuncle of other sites
0.000 0.387 0.613
M32.1 Systemic lupus erythematosus with organ or system involvement
0.000 0.387 0.613
H02.5 Other disorders affecting eyelid function
0.000 0.388 0.612
F45 Somatoform disorders
0.000 0.388 0.612
H01.0 Blepharitis
0.000 0.389 0.611
H18.6 Keratoconus
0.000 0.389 0.611
M80.90 Unspecified osteoporosis with pathological fracture (Multiple sites)
0.000 0.390 0.610
B37.2 Candidiasis of skin and nail
0.000 0.390 0.610
J99 Respiratory disorders in diseases classified elsewhere
0.000 0.391 0.609
B48 Other mycoses, not elsewhere classified
0.000 0.391 0.609
B47 Mycetoma
0.000 0.391 0.609
B46 Zygomycosis
0.000 0.391 0.609
B45 Cryptococcosis
0.000 0.391 0.609
B43 Chromomycosis and phaeomycotic abscess
0.000 0.391 0.609
B42 Sporotrichosis
0.000 0.391 0.609
B41 Paracoccidioidomycosis
0.000 0.391 0.609
B40 Blastomycosis
0.000 0.391 0.609
B39 Histoplasmosis
0.000 0.391 0.609
B38 Coccidioidomycosis
0.000 0.391 0.609
L95 Vasculitis limited to skin, not elsewhere classified
0.000 0.392 0.608
D52 Folate deficiency anaemia
0.000 0.393 0.607
M91-M94 Chondropathies
0.000 0.393 0.607
J95.5 Postprocedural subglottic stenosis
0.000 0.394 0.606
J95.4 Mendelson's syndrome
0.000 0.394 0.606
J95.3 Chronic pulmonary insufficiency following surgery
0.000 0.394 0.606
J95.2 Acute pulmonary insufficiency following nonthoracic surgery
0.000 0.394 0.606
J95.1 Acute pulmonary insufficiency following thoracic surgery
0.000 0.394 0.606
E11.0 With coma
0.000 0.394 0.606
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot
0.000 0.395 0.605
H06.3 Other disorders of orbit in diseases classified elsewhere
0.000 0.395 0.604
H06.1 Parasitic infestation of orbit in diseases classified elsewhere
0.000 0.395 0.604
H06.0 Disorders of lachrymal system in diseases classified elsewhere
0.000 0.395 0.604
A60 Anogenital herpesviral [herpes simplex] infections
0.000 0.396 0.604
L20.9 Atopic dermatitis, unspecified
0.000 0.396 0.604
N48.4 Impotence of organic origin
0.604 0.396 0.000
M21.9 Acquired deformity of limb, unspecified
0.000 0.397 0.603
M21.8 Other specified acquired deformities of limbs
0.000 0.397 0.603
E40-E46 Malnutrition
0.000 0.397 0.603
B37.7 Candidal septicaemia
0.000 0.397 0.603
B37.6 Candidal endocarditis
0.000 0.397 0.603
B37.5 Candidal meningitis
0.000 0.397 0.603
N45 Orchitis and epididymitis
0.602 0.398 0.000
E78.4 Other hyperlipidaemia
0.000 0.398 0.602
B50-B64 Protozoal diseases
0.000 0.399 0.601
L29.3 Anogenital pruritus, unspecified
0.000 0.399 0.601
L29.1 Pruritus scroti
0.000 0.399 0.601
J02.9 Acute pharyngitis, unspecified
0.000 0.402 0.598
E53 Deficiency of other B group vitamins
0.000 0.402 0.598
F20.9 Schizophrenia, unspecified
0.000 0.403 0.597
H57.8 Other specified disorders of eye and adnexa
0.000 0.403 0.597
F30.0 Hypomania
0.000 0.403 0.597
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.000 0.404 0.596
E74 Other disorders of carbohydrate metabolism
0.000 0.404 0.596
F45.8 Other somatoform disorders
0.000 0.406 0.594
A59 Trichomoniasis
0.000 0.406 0.594
A56 Other sexually transmitted chlamydial diseases
0.000 0.406 0.594
A54 Gonococcal infection
0.000 0.406 0.594
A53 Other and unspecified syphilis
0.000 0.406 0.594
A52 Late syphilis
0.000 0.406 0.594
A51 Early syphilis
0.000 0.406 0.594

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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