TreeWAS – Variant ID: rs78807522

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
I25 Chronic ischaemic heart disease	0.000	0.000	1.000
I25.1 Atherosclerotic heart disease	0.000	0.000	1.000
Chapter XV Pregnancy, childbirth and the puerperium	0.998	0.002	0.000
I20-I25 Ischaemic heart diseases	0.000	0.002	0.998
I25.8 Other forms of chronic ischaemic heart disease	0.000	0.004	0.996
O20-O29 Other maternal disorders predominantly related to pregnancy	0.995	0.005	0.000
O60-O75 Complications of labour and delivery	0.994	0.006	0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems	0.990	0.010	0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias	0.000	0.014	0.986
I20 Angina pectoris	0.000	0.015	0.985
E78.5 Hyperlipidaemia, unspecified	0.000	0.017	0.983
O68 Labour and delivery complicated by foetal stress [distress]	0.981	0.019	0.000
I20.9 Angina pectoris, unspecified	0.000	0.021	0.979
E78.0 Pure hypercholesterolaemia	0.000	0.023	0.977
E70-E90 Metabolic disorders	0.000	0.024	0.976
I10 Essential (primary) hypertension	0.000	0.034	0.966
O68.9 Labour and delivery complicated by foetal stress, unspecified	0.964	0.036	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.000	0.036	0.964
E65-E68 Obesity and other hyperalimentation	0.000	0.040	0.960
E66 Obesity	0.000	0.040	0.960
I21 Acute myocardial infarction	0.000	0.043	0.957
E66.9 Obesity, unspecified	0.000	0.043	0.957
O42 Premature rupture of membranes	0.943	0.057	0.000
E10-E14 Diabetes mellitus	0.000	0.057	0.943
I25.2 Old myocardial infarction	0.000	0.058	0.942
I21.1 Acute transmural myocardial infarction of inferior wall	0.000	0.060	0.940
O26 Maternal care for other conditions predominantly related to pregnancy	0.939	0.061	0.000
O20 Haemorrhage in early pregnancy	0.939	0.061	0.000
E11 Non-insulin-dependent diabetes mellitus	0.000	0.062	0.938
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium	0.930	0.070	0.000
I10-I15 Hypertensive diseases	0.000	0.080	0.920
O20.0 Threatened abortion	0.907	0.093	0.000
O68.1 Labour and delivery complicated by meconium in amniotic fluid	0.898	0.102	0.000
O42.9 Premature rupture of membranes, unspecified	0.897	0.103	0.000
O35 Maternal care for known or suspected foetal abnormality and damage	0.894	0.106	0.000
E86 Volume depletion	0.000	0.107	0.893
O34 Maternal care for known or suspected abnormality of pelvic organs	0.892	0.108	0.000
O36 Maternal care for other known or suspected foetal problems	0.888	0.112	0.000
E66.8 Other obesity	0.000	0.114	0.886
E11.2 With renal complications	0.000	0.116	0.884
I12 Hypertensive renal disease	0.000	0.118	0.882
O30 Multiple gestation	0.878	0.122	0.000
O14 Gestational [pregnancy-induced] hypertension with significant proteinuria	0.878	0.122	0.000
I22 Subsequent myocardial infarction	0.000	0.123	0.877
O21 Excessive vomiting in pregnancy	0.868	0.132	0.000
E78.2 Mixed hyperlipidaemia	0.000	0.136	0.864
I21.0 Acute transmural myocardial infarction of anterior wall	0.000	0.146	0.854
O68.8 Labour and delivery complicated by other evidence of foetal stress	0.852	0.148	0.000
O80-O84 Delivery	0.850	0.150	0.000
I25.9 Chronic ischaemic heart disease, unspecified	0.000	0.150	0.850
O72 Postpartum haemorrhage	0.847	0.153	0.000
O28 Abnormal findings on antenatal screening of mother	0.834	0.165	0.000
O23 Infections of genito-urinary tract in pregnancy	0.831	0.169	0.000
I12.0 Hypertensive renal disease with renal failure	0.000	0.171	0.829
E11.4 With neurological complications	0.000	0.175	0.825
O14.9 Preeclampsia, unspecified	0.824	0.176	0.000
E83 Disorders of mineral metabolism	0.000	0.176	0.824
O62 Abnormalities of forces of labour	0.821	0.179	0.000
O26.8 Other specified pregnancy-related conditions	0.819	0.181	0.000
O41 Other disorders of amniotic fluid and membranes	0.819	0.181	0.000
O00-O08 Pregnancy with abortive outcome	0.816	0.184	0.000
O63 Long labour	0.812	0.188	0.000
E11.3 With ophthalmic complications	0.000	0.188	0.812
E11.6 With other specified complications	0.000	0.190	0.810
O61 Failed induction of labour	0.801	0.199	0.000
O30.0 Twin pregnancy	0.798	0.202	0.000
O75 Other complications of labour and delivery, not elsewhere classified	0.797	0.203	0.000
O13 Gestational [pregnancy-induced] hypertension without significant proteinuria	0.795	0.205	0.000
O85-O92 Complications predominantly related to the puerperium	0.792	0.208	0.000
E78.4 Other hyperlipidaemia	0.000	0.210	0.790
O82 Single delivery by Caesarean section	0.790	0.210	0.000
O35.9 Maternal care for (suspected) foetal abnormality and damage, unspecified	0.787	0.213	0.000
Chapter IX Diseases of the circulatory system	0.000	0.215	0.785
O72.2 Delayed and secondary postpartum haemorrhage	0.780	0.220	0.000
O34.4 Maternal care for other abnormalities of cervix	0.777	0.223	0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.000	0.224	0.776
O74 Complications of anaesthesia during labour and delivery	0.774	0.226	0.000
I21.2 Acute transmural myocardial infarction of other sites	0.000	0.227	0.773
O68.3 Labour and delivery complicated by biochemical evidence of foetal stress	0.773	0.227	0.000
O47 False labour	0.770	0.230	0.000
E83.3 Disorders of phosphorus metabolism	0.000	0.233	0.767
O66 Other obstructed labour	0.767	0.233	0.000
E11.5 With peripheral circulatory complications	0.000	0.237	0.763
O33 Maternal care for known or suspected disproportion	0.760	0.240	0.000
O35.1 Maternal care for (suspected) chromosomal abnormality in foetus	0.758	0.242	0.000
O36.3 Maternal care for signs of foetal hypoxia	0.757	0.243	0.000
I22.9 Subsequent myocardial infarction of unspecified site	0.000	0.245	0.755
O36.5 Maternal care for poor foetal growth	0.755	0.245	0.000
O03 Spontaneous abortion	0.755	0.245	0.000
O12 Gestational [pregnancy-induced] oedema and proteinuria without hypertension	0.754	0.246	0.000
O42.1 Premature rupture of membranes, onset of labour after 24 hours	0.753	0.247	0.000
I12.9 Hypertensive renal disease without renal failure	0.000	0.247	0.753
E85 Amyloidosis	0.000	0.252	0.748
O26.9 Pregnancy-related condition, unspecified	0.743	0.257	0.000
E13 Other specified diabetes mellitus	0.000	0.258	0.742
I25.4 Coronary artery aneurysm	0.000	0.258	0.742
O82.0 Delivery by elective Caesarean section	0.741	0.259	0.000
E11.9 Without complications	0.000	0.259	0.741
O73 Retained placenta and membranes, without haemorrhage	0.738	0.262	0.000
O21.0 Mild hyperemesis gravidarum	0.738	0.262	0.000
O22 Venous complications in pregnancy	0.738	0.262	0.000
O34.1 Maternal care for tumour of corpus uteri	0.736	0.264	0.000
O26.7 Subluxation of symphysis (pubis) in pregnancy, childbirth and the puerperium	0.736	0.264	0.000
O26.6 Liver disorders in pregnancy, childbirth and the puerperium	0.736	0.264	0.000
E11.0 With coma	0.000	0.266	0.734
O20.8 Other haemorrhage in early pregnancy	0.731	0.269	0.000
O71 Other obstetric trauma	0.731	0.269	0.000
O26.2 Pregnancy care of habitual aborter	0.729	0.271	0.000
O21.1 Hyperemesis gravidarum with metabolic disturbance	0.724	0.276	0.000
I22.1 Subsequent myocardial infarction of inferior wall	0.000	0.277	0.723
O36.4 Maternal care for intra-uterine death	0.723	0.277	0.000
E83.1 Disorders of iron metabolism	0.000	0.281	0.719
I25.6 Silent myocardial ischaemia	0.000	0.283	0.717
I23 Certain current complications following acute myocardial infarction	0.000	0.283	0.717
O63.9 Long labour, unspecified	0.715	0.285	0.000
O62.2 Other uterine inertia	0.714	0.286	0.000
O29 Complications of anaesthesia during pregnancy	0.714	0.286	0.000
O25 Malnutrition in pregnancy	0.714	0.286	0.000
O65 Obstructed labour due to maternal pelvic abnormality	0.712	0.288	0.000
O60 Preterm delivery	0.712	0.288	0.000
O31 Complications specific to multiple gestation	0.710	0.290	0.000
O75.6 Delayed delivery after spontaneous or unspecified rupture of membranes	0.709	0.291	0.000
E78.6 Lipoprotein deficiency	0.000	0.293	0.707
E78.3 Hyperchylomicronaemia	0.000	0.293	0.707
O14.1 Severe preeclampsia	0.706	0.294	0.000
E84 Cystic fibrosis	0.000	0.300	0.700
E79 Disorders of purine and pyrimidine metabolism	0.000	0.300	0.700
E77 Disorders of glycoprotein metabolism	0.000	0.300	0.700
E76 Disorders of glycosaminoglycan metabolism	0.000	0.300	0.700
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.000	0.300	0.700
E72 Other disorders of amino-acid metabolism	0.000	0.300	0.700
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.000	0.300	0.700
E70 Disorders of aromatic amino-acid metabolism	0.000	0.300	0.700
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.000	0.300	0.700
I20.0 Unstable angina	0.000	0.301	0.699
O36.0 Maternal care for rhesus isoimmunisation	0.698	0.302	0.000
I21.3 Acute transmural myocardial infarction of unspecified site	0.000	0.302	0.698
O94-O99 Other obstetric conditions, not elsewhere classified	0.697	0.303	0.000
E80 Disorders of porphyrin and bilirubin metabolism	0.000	0.306	0.694
I20.1 Angina pectoris with documented spasm	0.000	0.306	0.694
E78.1 Pure hyperglyceridaemia	0.000	0.307	0.693
O41.0 Oligohydramnios	0.691	0.309	0.000
O03.4 Incomplete, without complication	0.690	0.310	0.000
E67 Other hyperalimentation	0.000	0.311	0.689
E68 Sequelae of hyperalimentation	0.000	0.311	0.689
E66.1 Drug-induced obesity	0.000	0.312	0.688
I21.X Presumed acute myicardial infaction (unconfirmed)	0.000	0.314	0.686
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.000	0.314	0.686
O23.4 Unspecified infection of urinary tract in pregnancy	0.685	0.315	0.000
I25.0 Atherosclerotic cardiovascular disease, so described	0.000	0.318	0.682
E00-E07 Disorders of thyroid gland	0.000	0.323	0.677
E66.2 Extreme obesity with alveolar hypoventilation	0.000	0.323	0.677
O42.2 Premature rupture of membranes, labour delayed by therapy	0.676	0.324	0.000
O40 Polyhydramnios	0.676	0.324	0.000
E12 Malnutrition-related diabetes mellitus	0.000	0.324	0.676
O42.0 Premature rupture of membranes, onset of labour within 24 hours	0.675	0.325	0.000
O28.1 Abnormal biochemical finding on antenatal screening of mother	0.673	0.327	0.000
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified	0.673	0.327	0.000
O26.5 Maternal hypotension syndrome	0.673	0.327	0.000
O26.4 Herpes gestationis	0.673	0.327	0.000
O26.3 Retained intra-uterine contraceptive device in pregnancy	0.673	0.327	0.000
O26.1 Low weight gain in pregnancy	0.673	0.327	0.000
O26.0 Excessive weight gain in pregnancy	0.673	0.327	0.000
E11.7 With multiple complications	0.000	0.327	0.673
E66.0 Obesity due to excess calories	0.000	0.332	0.668
O15 Eclampsia	0.667	0.333	0.000
O11 Pre-existing hypertensive disorder with superimposed proteinuria	0.667	0.333	0.000
E74 Other disorders of carbohydrate metabolism	0.000	0.334	0.666
O28.3 Abnormal ultrasonic finding on antenatal screening of mother	0.665	0.335	0.000
O34.8 Maternal care for other abnormalities of pelvic organs	0.664	0.336	0.000
O24 Diabetes mellitus in pregnancy	0.663	0.336	0.000
O61.0 Failed medical induction of labour	0.663	0.337	0.000
I13 Hypertensive heart and renal disease	0.000	0.340	0.660
O21.8 Other vomiting complicating pregnancy	0.659	0.340	0.000
E78.9 Disorder of lipoprotein metabolism, unspecified	0.000	0.341	0.659
E89.0 Postprocedural hypothyroidism	0.000	0.346	0.654
E73 Lactose intolerance	0.000	0.347	0.653
O81 Single delivery by forceps and vacuum extractor	0.646	0.354	0.000
O23.9 Other and unspecified genito-urinary tract infection in pregnancy	0.646	0.354	0.000
O90 Complications of the puerperium, not elsewhere classified	0.646	0.354	0.000
O72.1 Other immediate postpartum haemorrhage	0.646	0.354	0.000
O34.7 Maternal care for abnormality of vulva and perineum	0.645	0.355	0.000
O35.7 Maternal care for (suspected) damage to foetus by other medical procedures	0.641	0.359	0.000
O35.6 Maternal care for (suspected) damage to foetus by radiation	0.641	0.359	0.000
O35.5 Maternal care for (suspected) damage to foetus by drugs	0.641	0.359	0.000
O35.4 Maternal care for (suspected) damage to foetus from alcohol	0.641	0.359	0.000
O35.3 Maternal care for (suspected) damage to foetus from viral disease in mother	0.641	0.359	0.000
O35.2 Maternal care for (suspected) hereditary disease in foetus	0.641	0.359	0.000
O35.0 Maternal care for (suspected) central nervous system malformation in foetus	0.641	0.359	0.000
O45 Premature separation of placenta [abruptio placentae]	0.641	0.359	0.000
O34.9 Maternal care for abnormality of pelvic organ, unspecified	0.639	0.360	0.000
O34.6 Maternal care for abnormality of vagina	0.639	0.360	0.000
O34.5 Maternal care for other abnormalities of gravid uterus	0.639	0.360	0.000
O34.0 Maternal care for congenital malformation of uterus	0.639	0.360	0.000
O63.0 Prolonged first stage (of labour)	0.639	0.361	0.000
O36.7 Maternal care for viable foetus in abdominal pregnancy	0.637	0.363	0.000
O36.2 Maternal care for hydrops foetalis	0.637	0.363	0.000
O36.1 Maternal care for other isoimmunisation	0.637	0.363	0.000
E11.1 With ketoacidosis	0.000	0.364	0.636
O12.1 Gestational proteinuria	0.631	0.369	0.000
O34.2 Maternal care due to uterine scar from previous surgery	0.630	0.370	0.000
O30.9 Multiple gestation, unspecified	0.630	0.370	0.000
O30.8 Other multiple gestation	0.630	0.370	0.000
O30.2 Quadruplet pregnancy	0.630	0.370	0.000
O30.1 Triplet pregnancy	0.630	0.370	0.000
O14.2 HELLP syndrome	0.630	0.370	0.000
O14.0 Moderate preeclampsia	0.629	0.370	0.000
O66.5 Failed application of vacuum extractor and forceps, unspecified	0.626	0.374	0.000
O21.2 Late vomiting of pregnancy	0.622	0.378	0.000
I22.8 Subsequent myocardial infarction of other sites	0.000	0.378	0.621
O75.2 Pyrexia during labour, not elsewhere classified	0.621	0.379	0.000
E04 Other non-toxic goitre	0.000	0.380	0.620
O34.3 Maternal care for cervical incompetence	0.619	0.381	0.000
O74.6 Other complications of spinal and epidural anaesthesia during labour and delivery	0.617	0.383	0.000
O86 Other puerperal infections	0.615	0.385	0.000
O44 Placenta praevia	0.612	0.388	0.000
O84 Multiple delivery	0.609	0.391	0.000
O83 Other assisted single delivery	0.609	0.391	0.000
O72.3 Postpartum coagulation defects	0.607	0.393	0.000
O12.2 Gestational oedema with proteinuria	0.606	0.394	0.000
O47.1 False labour at or after 37 completed weeks of gestation	0.606	0.394	0.000
O43 Placental disorders	0.605	0.395	0.000
O89 Complications of anaesthesia during the puerperium	0.603	0.396	0.000
I22.0 Subsequent myocardial infarction of anterior wall	0.000	0.397	0.603
Z82.4 Family history of ischaemic heart disease and other diseases of the circulatory system	0.000	0.398	0.602
I15 Secondary hypertension	0.000	0.399	0.601
O10 Pre-existing hypertension complicating pregnancy, childbirth and the puerperium	0.601	0.399	0.000
O36.9 Maternal care for foetal problem, unspecified	0.601	0.399	0.000
O03.1 Incomplete, complicated by delayed or excessive haemorrhage	0.600	0.400	0.000
E13.9 Without complications	0.000	0.401	0.598
O28.9 Abnormal finding on antenatal screening of mother, unspecified	0.598	0.402	0.000
O28.8 Other abnormal findings on antenatal screening of mother	0.598	0.402	0.000
O28.5 Abnormal chromosomal and genetic finding on antenatal screening of mother	0.598	0.402	0.000
O28.4 Abnormal radiological finding on antenatal screening of mother	0.598	0.402	0.000
O28.2 Abnormal cytological finding on antenatal screening of mother	0.598	0.402	0.000
O28.0 Abnormal haematological finding on antenatal screening of mother	0.598	0.402	0.000
O62.0 Primary inadequate contractions	0.598	0.402	0.000
O41.8 Other specified disorders of amniotic fluid and membranes	0.597	0.402	0.000
O69 Labour and delivery complicated by umbilical cord complications	0.597	0.403	0.000
E85.9 Amyloidosis, unspecified	0.000	0.403	0.596
O23.3 Infections of other parts of urinary tract in pregnancy	0.596	0.404	0.000
O23.2 Infections of urethra in pregnancy	0.596	0.404	0.000
O23.1 Infections of bladder in pregnancy	0.596	0.404	0.000
O23.0 Infections of kidney in pregnancy	0.596	0.404	0.000
O33.9 Maternal care for disproportion, unspecified	0.595	0.405	0.000
O35.8 Maternal care for other (suspected) foetal abnormality and damage	0.594	0.405	0.000
E83.9 Disorder of mineral metabolism, unspecified	0.000	0.409	0.591
E83.8 Other disorders of mineral metabolism	0.000	0.409	0.591
E83.2 Disorders of zinc metabolism	0.000	0.409	0.591
E83.0 Disorders of copper metabolism	0.000	0.409	0.591
E04.2 Non-toxic multinodular goitre	0.000	0.410	0.590
I20.8 Other forms of angina pectoris	0.000	0.411	0.589
O62.9 Abnormality of forces of labour, unspecified	0.589	0.411	0.000
O62.8 Other abnormalities of forces of labour	0.589	0.411	0.000
O82.1 Delivery by emergency Caesarean section	0.589	0.411	0.000
O23.5 Infections of the genital tract in pregnancy	0.588	0.412	0.000
O41.9 Disorder of amniotic fluid and membranes, unspecified	0.587	0.413	0.000
O41.1 Infection of amniotic sac and membranes	0.587	0.413	0.000
O07 Failed attempted abortion	0.585	0.415	0.000
O06 Unspecified abortion	0.585	0.415	0.000
O05 Other abortion	0.585	0.415	0.000
O01 Hydatidiform mole	0.585	0.415	0.000
E14 Unspecified diabetes mellitus	0.000	0.415	0.585
O63.2 Delayed delivery of second twin, triplet, etc.	0.582	0.418	0.000
O92 Other disorders of breast and lactation associated with childbirth	0.582	0.418	0.000
O36.8 Maternal care for other specified foetal problems	0.582	0.418	0.000
O08 Complications following abortion and ectopic and molar pregnancy	0.580	0.420	0.000
O32 Maternal care for known or suspected malpresentation of foetus	0.579	0.420	0.000
E89.3 Postprocedural hypopituitarism	0.000	0.421	0.579
O62.3 Precipitate labour	0.579	0.421	0.000
O61.9 Failed induction of labour, unspecified	0.574	0.426	0.000
O61.8 Other failed induction of labour	0.574	0.426	0.000
O61.1 Failed instrumental induction of labour	0.574	0.426	0.000
I25.3 Aneurysm of heart	0.000	0.426	0.574
O62.4 Hypertonic, incoordinate and prolonged uterine contractions	0.574	0.426	0.000
O47.0 False labour before 37 completed weeks of gestation	0.572	0.428	0.000
O75.9 Complication of labour and delivery, unspecified	0.572	0.428	0.000
O75.5 Delayed delivery after artificial rupture of membranes	0.572	0.428	0.000
O75.4 Other complications of obstetric surgery and procedures	0.572	0.428	0.000
O75.3 Other infection during labour	0.572	0.428	0.000
O75.1 Shock during or following labour and delivery	0.572	0.428	0.000
O62.1 Secondary uterine inertia	0.570	0.430	0.000
O73.0 Retained placenta, without haemorrhage	0.570	0.430	0.000
O82.9 Delivery by Caesarean section, unspecified	0.570	0.430	0.000
O91 Infections of breast associated with childbirth	0.568	0.432	0.000
O88 Obstetric embolism	0.568	0.432	0.000
O71.8 Other specified obstetric trauma	0.568	0.432	0.000
I11 Hypertensive heart disease	0.000	0.433	0.566
O82.8 Other single delivery by Caesarean section	0.566	0.434	0.000
O82.2 Delivery by Caesarean hysterectomy	0.566	0.434	0.000
O75.8 Other specified complications of labour and delivery	0.560	0.440	0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified	0.000	0.444	0.556
E89.8 Other postprocedural endocrine and metabolic disorders	0.000	0.444	0.556
E89.5 Postprocedural testicular hypofunction	0.000	0.444	0.556
E89.4 Postprocedural ovarian failure	0.000	0.444	0.556
E89.1 Postprocedural hypoinsulinaemia	0.000	0.444	0.556
O74.9 Complication of anaesthesia during labour and delivery, unspecified	0.555	0.445	0.000
O74.8 Other complications of anaesthesia during labour and delivery	0.555	0.445	0.000
O74.7 Failed or difficult intubation during labour and delivery	0.555	0.445	0.000
O74.5 Spinal and epidural anaesthesia-induced headache during labour and delivery	0.555	0.445	0.000
O74.4 Toxic reaction to local anaesthesia during labour and delivery	0.555	0.445	0.000
O74.3 Central nervous system complications of anaesthesia during labour and delivery	0.555	0.445	0.000
O74.2 Cardiac complications of anaesthesia during labour and delivery	0.555	0.445	0.000
O74.1 Other pulmonary complications of anaesthesia during labour and delivery	0.555	0.445	0.000
O74.0 Aspiration pneumonitis due to anaesthesia during labour and delivery	0.555	0.445	0.000
O22.0 Varicose veins of lower extremity in pregnancy	0.555	0.445	0.000
O71.7 Obstetric haematoma of pelvis	0.554	0.446	0.000
O03.9 Complete or unspecified, without complication	0.552	0.448	0.000
O75.0 Maternal distress during labour and delivery	0.550	0.450	0.000
O66.9 Obstructed labour, unspecified	0.550	0.450	0.000
O66.8 Other specified obstructed labour	0.550	0.450	0.000
O66.4 Failed trial of labour, unspecified	0.550	0.450	0.000
O66.3 Obstructed labour due to other abnormalities of foetus	0.550	0.450	0.000
O66.2 Obstructed labour due to unusually large foetus	0.550	0.450	0.000
O66.1 Obstructed labour due to locked twins	0.550	0.450	0.000
O02 Other abnormal products of conception	0.548	0.452	0.000
O33.8 Maternal care for disproportion of other origin	0.545	0.455	0.000
O33.7 Maternal care for disproportion due to other foetal deformities	0.545	0.455	0.000
O33.6 Maternal care for disproportion due to hydrocephalic foetus	0.545	0.455	0.000
O33.5 Maternal care for disproportion due to unusually large foetus	0.545	0.455	0.000
O33.4 Maternal care for disproportion of mixed maternal and foetal origin	0.545	0.455	0.000
O33.3 Maternal care for disproportion due to outlet contraction of pelvis	0.545	0.455	0.000
O33.2 Maternal care for disproportion due to inlet contraction of pelvis	0.545	0.455	0.000
O33.1 Maternal care for disproportion due to generally contracted pelvis	0.545	0.455	0.000
O33.0 Maternal care for disproportion due to deformity of maternal pelvic bones	0.545	0.455	0.000
O03.8 Complete or unspecified, with other and unspecified complications	0.541	0.459	0.000
O03.7 Complete or unspecified, complicated by embolism	0.541	0.459	0.000
O03.6 Complete or unspecified, complicated by delayed or excessive haemorrhage	0.541	0.459	0.000
O03.5 Complete or unspecified, complicated by genital tract and pelvic infection	0.541	0.459	0.000
O03.3 Incomplete, with other and unspecified complications	0.541	0.459	0.000
O03.2 Incomplete, complicated by embolism	0.541	0.459	0.000
O03.0 Incomplete, complicated by genital tract and pelvic infection	0.541	0.459	0.000
O47.9 False labour, unspecified	0.539	0.461	0.000
E06 Thyroiditis	0.000	0.462	0.538
E85.8 Other amyloidosis	0.000	0.463	0.537
E85.3 Secondary systemic amyloidosis	0.000	0.463	0.537
E85.2 Heredofamilial amyloidosis, unspecified	0.000	0.463	0.537
E85.1 Neuropathic heredofamilial amyloidosis	0.000	0.463	0.537
E85.0 Nonneuropathic heredofamilial amyloidosis	0.000	0.463	0.537
E11.8 With unspecified complications	0.000	0.463	0.536
E13.8 With unspecified complications	0.000	0.468	0.532
E13.7 With multiple complications	0.000	0.468	0.532
E13.6 With other specified complications	0.000	0.468	0.532
E13.5 With peripheral circulatory complications	0.000	0.468	0.532
E13.4 With neurological complications	0.000	0.468	0.532
E13.3 With ophthalmic complications	0.000	0.468	0.532
E13.2 With renal complications	0.000	0.468	0.532
E13.1 With ketoacidosis	0.000	0.468	0.532
E13.0 With coma	0.000	0.468	0.532
E40-E46 Malnutrition	0.000	0.468	0.532
E89.6 Postprocedural adrenocortical(-medullary) hypofunction	0.000	0.470	0.530
O22.9 Venous complication in pregnancy, unspecified	0.529	0.471	0.000
O22.8 Other venous complications in pregnancy	0.529	0.471	0.000
O22.5 Cerebral venous thrombosis in pregnancy	0.529	0.471	0.000
O22.3 Deep phlebothrombosis in pregnancy	0.529	0.471	0.000
O22.2 Superficial thrombophlebitis in pregnancy	0.529	0.471	0.000
O22.1 Genital varices in pregnancy	0.529	0.471	0.000
O64 Obstructed labour due to malposition and malpresentation of foetus	0.528	0.472	0.000
O22.4 Haemorrhoids in pregnancy	0.527	0.473	0.000
O71.9 Obstetric trauma, unspecified	0.524	0.476	0.000
O71.6 Obstetric damage to pelvic joints and ligaments	0.524	0.476	0.000
O71.5 Other obstetric injury to pelvic organs	0.524	0.476	0.000
O71.3 Obstetric laceration of cervix	0.524	0.476	0.000
O71.2 Postpartum inversion of uterus	0.524	0.476	0.000
O71.1 Rupture of uterus during labour	0.524	0.476	0.000
O71.0 Rupture of uterus before onset of labour	0.524	0.476	0.000
E78.8 Other disorders of lipoprotein metabolism	0.000	0.477	0.523
O90.9 Complication of the puerperium, unspecified	0.523	0.477	0.000
O04 Medical abortion	0.522	0.478	0.000
E85.4 Organ-limited amyloidosis	0.000	0.479	0.521
O21.9 Vomiting of pregnancy, unspecified	0.520	0.480	0.000
E89.2 Postprocedural hypoparathyroidism	0.000	0.482	0.518
O66.0 Obstructed labour due to shoulder dystocia	0.517	0.483	0.000
I23.8 Other current complications following acute myocardial infarction	0.000	0.485	0.515
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction	0.000	0.486	0.514
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction	0.000	0.486	0.514
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction	0.000	0.486	0.514
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction	0.000	0.486	0.514
I23.2 Ventricular septal defect as current complication following acute myocardial infarction	0.000	0.486	0.514
I23.1 Atrial septal defect as current complication following acute myocardial infarction	0.000	0.486	0.514
I23.0 Haemopericardium as current complication following acute myocardial infarction	0.000	0.486	0.514
O85 Puerperal sepsis	0.514	0.486	0.000
O29.9 Complication of anaesthesia during pregnancy, unspecified	0.512	0.488	0.000
O29.8 Other complications of anaesthesia during pregnancy	0.512	0.488	0.000
O29.6 Failed or difficult intubation during pregnancy	0.512	0.488	0.000
O29.5 Other complications of spinal and epidural anaesthesia during pregnancy	0.512	0.488	0.000
O29.4 Spinal and epidural anaesthesia-induced headache during pregnancy	0.512	0.488	0.000
O29.3 Toxic reaction to local anaesthesia during pregnancy	0.512	0.488	0.000
O29.2 Central nervous system complications of anaesthesia during pregnancy	0.512	0.488	0.000
O29.1 Cardiac complications of anaesthesia during pregnancy	0.512	0.488	0.000
O29.0 Pulmonary complications of anaesthesia during pregnancy	0.512	0.488	0.000
I70-I79 Diseases of arteries, arterioles and capillaries	0.000	0.488	0.512
O73.1 Retained portions of placenta and membranes, without haemorrhage	0.511	0.489	0.000
O60.3 Preterm delivery without spontaneous labour	0.511	0.489	0.000
O60.2 Preterm spontaneous labour with term delivery	0.511	0.489	0.000
O60.1 Preterm spontaneous labour with preterm delivery	0.511	0.489	0.000
O60.0 Preterm labour without delivery	0.511	0.489	0.000
O65.9 Obstructed labour due to maternal pelvic abnormality, unspecified	0.511	0.489	0.000
O65.8 Obstructed labour due to other maternal pelvic abnormalities	0.511	0.489	0.000
O65.5 Obstructed labour due to abnormality of maternal pelvic organs	0.511	0.489	0.000
O65.4 Obstructed labour due to foetopelvic disproportion, unspecified	0.511	0.489	0.000
O65.3 Obstructed labour due to pelvic outlet and midcavity contraction	0.511	0.489	0.000
O65.2 Obstructed labour due to pelvic inlet contraction	0.511	0.489	0.000
O65.1 Obstructed labour due to generally contracted pelvis	0.511	0.489	0.000
O65.0 Obstructed labour due to deformed pelvis	0.511	0.489	0.000
I00-I02 Acute rheumatic fever	0.000	0.490	0.510
O20.9 Haemorrhage in early pregnancy, unspecified	0.509	0.491	0.000
O31.8 Other complications specific to multiple gestation	0.509	0.491	0.000
O31.2 Continuing pregnancy after intra-uterine death of one foetus or more	0.509	0.491	0.000
O31.1 Continuing pregnancy after abortion of one foetus or more	0.509	0.491	0.000
O31.0 Papyraceous foetus	0.509	0.491	0.000
E65 Localised adiposity	0.000	0.492	0.508
O36.6 Maternal care for excessive foetal growth	0.506	0.494	0.000
E70.9 Disorder of aromatic amino-acid metabolism, unspecified	0.000	0.498	0.502
E70.8 Other disorders of aromatic amino-acid metabolism	0.000	0.498	0.502
E70.3 Albinism	0.000	0.498	0.502
E70.2 Disorders of tyrosine metabolism	0.000	0.498	0.502
E70.1 Other hyperphenylalaninaemias	0.000	0.498	0.502
E70.0 Classical phenylketonuria	0.000	0.498	0.502
E71.3 Disorders of fatty-acid metabolism	0.000	0.498	0.502
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified	0.000	0.498	0.502
E71.1 Other disorders of branched-chain amino-acid metabolism	0.000	0.498	0.502
E71.0 Maple-syrup-urine disease	0.000	0.498	0.502
E72.9 Disorder of amino-acid metabolism, unspecified	0.000	0.498	0.502
E72.8 Other specified disorders of amino-acid metabolism	0.000	0.498	0.502
E72.5 Disorders of glycine metabolism	0.000	0.498	0.502
E72.4 Disorders of ornithine metabolism	0.000	0.498	0.502
E72.3 Disorders of lysine and hydroxylysine metabolism	0.000	0.498	0.502
E72.2 Disorders of urea cycle metabolism	0.000	0.498	0.502
E72.1 Disorders of sulphur-bearing amino-acid metabolism	0.000	0.498	0.502
E72.0 Disorders of amino-acid transport	0.000	0.498	0.502
E75.6 Lipid storage disorder, unspecified	0.000	0.498	0.502
E75.5 Other lipid storage disorders	0.000	0.498	0.502
E75.4 Neuronal ceroid lipofuscinosis	0.000	0.498	0.502
E75.3 Sphingolipidosis, unspecified	0.000	0.498	0.502
E75.2 Other sphingolipidosis	0.000	0.498	0.502
E75.1 Other gangliosidosis	0.000	0.498	0.502
E75.0 GM2 gangliosidosis	0.000	0.498	0.502
E76.9 Disorder of glucosaminoglycan metabolism, unspecified	0.000	0.498	0.502
E76.8 Other disorders of glucosaminoglycan metabolism	0.000	0.498	0.502
E76.3 Mucopolysaccharidosis, unspecified	0.000	0.498	0.502
E76.2 Other mucopolysaccharidoses	0.000	0.498	0.502
E76.1 Mucopolysaccharidosis, type II	0.000	0.498	0.502
E76.0 Mucopolysaccharidosis, type I	0.000	0.498	0.502
E77.9 Disorder of glycoprotein metabolism, unspecified	0.000	0.498	0.502
E77.8 Other disorders of glycoprotein metabolism	0.000	0.498	0.502
E77.1 Defects in glycoprotein degradation	0.000	0.498	0.502
E77.0 Defects in posttranslational modification of lysosomal enzymes	0.000	0.498	0.502
E79.9 Disorder of purine and pyrimidine metabolism, unspecified	0.000	0.498	0.502
E79.8 Other disorders of purine and pyrimidine metabolism	0.000	0.498	0.502
E79.1 Lesch-Nyhan syndrome	0.000	0.498	0.502
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease	0.000	0.498	0.502
E84.9 Cystic fibrosis, unspecified	0.000	0.498	0.502
E84.8 Cystic fibrosis with other manifestations	0.000	0.498	0.502
E84.1 Cystic fibrosis with intestinal manifestations	0.000	0.498	0.502
E84.0 Cystic fibrosis with pulmonary manifestations	0.000	0.498	0.502
O81.4 Vacuum extractor delivery	0.502	0.498	0.000
O98 Maternal infectious and parasitic diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium	0.500	0.500	0.000
O97 Death from sequelae of direct obstetric causes	0.500	0.500	0.000
O96 Death from any obstetric cause occurring more than 42 days but less than one year after delivery	0.500	0.500	0.000
O95 Obstetric death of unspecified cause	0.500	0.500	0.000
O94 Sequelae of complication of pregnancy, childbirth and the puerperium	0.500	0.500	0.000
O87 Venous complications in the puerperium	0.498	0.501	0.000
E80.7 Disorder of bilirubin metabolism, unspecified	0.000	0.502	0.498
E80.6 Other disorders of bilirubin metabolism	0.000	0.502	0.498
E80.5 Crigler-Najjar syndrome	0.000	0.502	0.498
E80.3 Defects of catalase and peroxydase	0.000	0.502	0.498
E80.2 Other porphyria	0.000	0.502	0.498
E80.1 Porphyria cutanea tarda	0.000	0.502	0.498
E80.0 Hereditary erythropoietic porphyria	0.000	0.502	0.498
O00 Ectopic pregnancy	0.494	0.506	0.000
O24.0 Pre-existing diabetes mellitus, insulin-dependent	0.494	0.506	0.000
E67.8 Other specified hyperalimentation	0.000	0.506	0.494
E67.3 Hypervitaminosis D	0.000	0.506	0.494
E67.2 Megavitamin-B6 syndrome	0.000	0.506	0.494
E67.1 Hypercarotenaemia	0.000	0.506	0.494
E67.0 Hypervitaminosis A	0.000	0.506	0.494
O70 Perineal laceration during delivery	0.494	0.506	0.000
E80.4 Gilbert's syndrome	0.000	0.507	0.493
O86.0 Infection of obstetric surgical wound	0.492	0.508	0.000
E15 Nondiabetic hypoglycaemic coma	0.000	0.508	0.492
E14.3 With ophthalmic complications	0.000	0.508	0.492
O90.8 Other complications of the puerperium, not elsewhere classified	0.491	0.508	0.000
O46 Antepartum haemorrhage, not elsewhere classified	0.488	0.512	0.000
E16 Other disorders of pancreatic internal secretion	0.000	0.513	0.487
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.514	0.486
E00 Congenital iodine-deficiency syndrome	0.000	0.514	0.486
E12.9 Without complications	0.000	0.515	0.484
E12.8 With unspecified complications	0.000	0.515	0.484
E12.7 With multiple complications	0.000	0.515	0.484
E12.6 With other specified complications	0.000	0.515	0.484
E12.5 With peripheral circulatory complications	0.000	0.515	0.484
E12.4 With neurological complications	0.000	0.515	0.484
E12.3 With ophthalmic complications	0.000	0.515	0.484
E12.2 With renal complications	0.000	0.515	0.484
E12.1 With ketoacidosis	0.000	0.515	0.484
E12.0 With coma	0.000	0.515	0.484
O67.8 Other intrapartum haemorrhage	0.483	0.517	0.000
O67.0 Intrapartum haemorrhage with coagulation defect	0.483	0.517	0.000
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium	0.481	0.519	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations