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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs80131195
log Bayes Factor = 8.81707
Chromosome 7   position 28,486,044  (GRCh37) Explore rs80131195 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
I25.8 Other forms of chronic ischaemic heart disease
1.000 0.000 0.000
I25 Chronic ischaemic heart disease
1.000 0.000 0.000
N80-N98 Noninflammatory disorders of female genital tract
0.999 0.001 0.000
# Top node
0.998 0.002 0.000
N92 Excessive, frequent and irregular menstruation
0.998 0.002 0.000
Chapter VIII Diseases of the ear and mastoid process
0.998 0.002 0.000
N81 Female genital prolapse
0.997 0.003 0.000
I25.1 Atherosclerotic heart disease
0.997 0.003 0.000
R06 Abnormalities of breathing
0.995 0.005 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.994 0.006 0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems
0.993 0.007 0.000
N92.1 Excessive and frequent menstruation with irregular cycle
0.993 0.007 0.000
N81.6 Rectocele
0.993 0.007 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.989 0.011 0.000
N85 Other noninflammatory disorders of uterus, except cervix
0.989 0.011 0.000
R06.5 Mouth breathing
0.986 0.014 0.000
H65-H75 Diseases of middle ear and mastoid
0.984 0.016 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.979 0.021 0.000
Chapter XIV Diseases of the genitourinary system
0.975 0.025 0.000
H80-H83 Diseases of inner ear
0.975 0.025 0.000
R06.0 Dyspnoea
0.971 0.029 0.000
S80-S89 Injuries to the knee and lower leg
0.967 0.033 0.000
R06.8 Other and unspecified abnormalities of breathing
0.967 0.033 0.000
R87 Abnormal findings in specimens from female genital organs
0.966 0.034 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.964 0.036 0.000
N85.2 Hypertrophy of uterus
0.964 0.036 0.000
N92.0 Excessive and frequent menstruation with regular cycle
0.960 0.040 0.000
R87.6 Abnormal cytological findings
0.958 0.042 0.000
H83 Other diseases of inner ear
0.955 0.045 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.953 0.047 0.000
M20-M25 Other joint disorders
0.949 0.051 0.000
M25 Other joint disorders, not elsewhere classified
0.942 0.058 0.000
H83.0 Labyrinthitis
0.942 0.058 0.000
I20-I25 Ischaemic heart diseases
0.932 0.068 0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee
0.927 0.073 0.000
N81.8 Other female genital prolapse
0.926 0.074 0.000
N94 Pain and other conditions associated with female genital organs and menstrual cycle
0.925 0.075 0.000
H74 Other disorders of middle ear and mastoid
0.925 0.075 0.000
M80-M85 Disorders of bone density and structure
0.922 0.078 0.000
Chapter I Certain infectious and parasitic diseases
0.919 0.081 0.000
N93 Other abnormal uterine and vaginal bleeding
0.911 0.089 0.000
H66 Suppurative and unspecified otitis media
0.910 0.090 0.000
I20 Angina pectoris
0.909 0.091 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.909 0.091 0.000
M84 Disorders of continuity of bone
0.909 0.091 0.000
M25.8 Other specified joint disorders
0.906 0.094 0.000
I20.9 Angina pectoris, unspecified
0.898 0.102 0.000
M84.1 Nonunion of fracture [pseudarthrosis]
0.897 0.103 0.000
N81.1 Cystocele
0.896 0.104 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.891 0.109 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.889 0.111 0.000
M86-M90 Other osteopathies
0.889 0.111 0.000
N85.1 Endometrial adenomatous hyperplasia
0.880 0.120 0.000
R01 Cardiac murmurs and other cardiac sounds
0.878 0.122 0.000
S50-S59 Injuries to the elbow and forearm
0.877 0.123 0.000
Chapter IX Diseases of the circulatory system
0.877 0.123 0.000
M25.5 Pain in joint
0.875 0.125 0.000
H66.3 Other chronic suppurative otitis media
0.871 0.129 0.000
N93.9 Abnormal uterine and vaginal bleeding, unspecified
0.866 0.134 0.000
R07 Pain in throat and chest
0.862 0.138 0.000
S83.2 Tear of meniscus, current
0.860 0.140 0.000
I25.3 Aneurysm of heart
0.860 0.140 0.000
R07.4 Chest pain, unspecified
0.858 0.142 0.000
M24 Other specific joint derangements
0.858 0.142 0.000
M25.57 Pain in joint (Ankle and foot)
0.856 0.144 0.000
R06.6 Hiccough
0.854 0.146 0.000
Q50-Q56 Congenital malformations of genital organs
0.853 0.147 0.000
I25.9 Chronic ischaemic heart disease, unspecified
0.849 0.151 0.000
T92 Sequelae of injuries of upper limb
0.845 0.155 0.000
M84.16 Nonunion of fracture [pseudarthrosis] (Lower leg)
0.844 0.156 0.000
R72 Abnormality of white blood cells, not elsewhere classified
0.842 0.158 0.000
S90-S99 Injuries to the ankle and foot
0.840 0.160 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.836 0.164 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.833 0.167 0.000
N87 Dysplasia of cervix uteri
0.832 0.168 0.000
I25.2 Old myocardial infarction
0.832 0.168 0.000
N92.4 Excessive bleeding in the premenopausal period
0.830 0.170 0.000
R73 Elevated blood glucose level
0.829 0.171 0.000
R04 Haemorrhage from respiratory passages
0.827 0.173 0.000
N85.0 Endometrial glandular hyperplasia
0.825 0.175 0.000
H81 Disorders of vestibular function
0.823 0.177 0.000
M87 Osteonecrosis
0.821 0.179 0.000
M21 Other acquired deformities of limbs
0.819 0.181 0.000
R47-R49 Symptoms and signs involving speech and voice
0.817 0.183 0.000
Chapter X Diseases of the respiratory system
0.815 0.185 0.000
M84.17 Nonunion of fracture [pseudarthrosis] (Ankle and foot)
0.811 0.189 0.000
N94.8 Other specified conditions associated with female genital organs and menstrual cycle
0.808 0.192 0.000
E83.1 Disorders of iron metabolism
0.808 0.192 0.000
H74.4 Polyp of middle ear
0.806 0.194 0.000
H60-H62 Diseases of external ear
0.806 0.194 0.000
B65-B83 Helminthiases
0.805 0.195 0.000
I20.0 Unstable angina
0.804 0.196 0.000
M65-M68 Disorders of synovium and tendon
0.803 0.197 0.000
E83 Disorders of mineral metabolism
0.802 0.198 0.000
N94.9 Unspecified condition associated with female genital organs and menstrual cycle
0.802 0.198 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.801 0.199 0.000
S10-S19 Injuries to the neck
0.800 0.200 0.000
S80 Superficial injury of lower leg
0.799 0.201 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.796 0.204 0.000
R01.1 Cardiac murmur, unspecified
0.794 0.206 0.000
H65 Nonsuppurative otitis media
0.794 0.206 0.000
N95 Menopausal and other perimenopausal disorders
0.792 0.208 0.000
R04.2 Haemoptysis
0.789 0.211 0.000
E70-E90 Metabolic disorders
0.789 0.211 0.000
M25.3 Other instability of joint
0.785 0.215 0.000
H71 Cholesteatoma of middle ear
0.784 0.216 0.000
I25.5 Ischaemic cardiomyopathy
0.783 0.216 0.000
T66-T78 Other and unspecified effects of external causes
0.783 0.217 0.000
M25.86 Other specified joint disorders (Lower leg)
0.778 0.222 0.000
J30-J39 Other diseases of upper respiratory tract
0.777 0.223 0.000
M24.8 Other specific joint derangements, not elsewhere classified
0.774 0.226 0.000
J38 Diseases of vocal cords and larynx, not elsewhere classified
0.773 0.227 0.000
H74.8 Other specified disorders of middle ear and mastoid
0.773 0.227 0.000
M84.11 Nonunion of fracture [pseudarthrosis] (Shoulder region)
0.770 0.229 0.000
H90-H95 Other disorders of ear
0.769 0.231 0.000
B25-B34 Other viral diseases
0.769 0.231 0.000
M25.87 Other specified joint disorders (Ankle and foot)
0.768 0.232 0.000
S83.6 Sprain and strain of other and unspecified parts of knee
0.768 0.232 0.000
S81 Open wound of lower leg
0.768 0.232 0.000
N85.4 Malposition of uterus
0.766 0.234 0.000
M25.81 Other specified joint disorders (Shoulder region)
0.765 0.235 0.000
B15-B19 Viral hepatitis
0.765 0.235 0.000
N94.5 Secondary dysmenorrhoea
0.764 0.236 0.000
B95-B98 Bacterial, viral and other infectious agents
0.763 0.237 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.763 0.237 0.000
S83.3 Tear of articular cartilage of knee, current
0.762 0.238 0.000
R49 Voice disturbances
0.761 0.239 0.000
S86 Injury of muscle and tendon at lower leg level
0.758 0.242 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.754 0.246 0.000
M25.54 Pain in joint (Hand)
0.753 0.247 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.750 0.250 0.000
M89 Other disorders of bone
0.750 0.250 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.748 0.251 0.000
T92.2 Sequelae of fracture at wrist and hand level
0.747 0.252 0.000
R73.0 Abnormal glucose tolerance test
0.746 0.254 0.000
N81.4 Uterovaginal prolapse, unspecified
0.746 0.254 0.000
M32 Systemic lupus erythematosus
0.746 0.254 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.745 0.255 0.000
T79-T79 Certain early complications of trauma
0.744 0.256 0.000
Q00-Q07 Congenital malformations of the nervous system
0.741 0.259 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.740 0.260 0.000
H74.9 Disorder of middle ear and mastoid, unspecified
0.739 0.261 0.000
M87.9 Osteonecrosis, unspecified
0.739 0.261 0.000
N81.5 Vaginal enterocele
0.738 0.262 0.000
M25.53 Pain in joint (Forearm)
0.735 0.265 0.000
N87.1 Moderate cervical dysplasia
0.734 0.266 0.000
I25.4 Coronary artery aneurysm
0.734 0.266 0.000
R86 Abnormal findings in specimens from male genital organs
0.733 0.267 0.000
J38.3 Other diseases of vocal cords
0.733 0.267 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.732 0.268 0.000
R09 Other symptoms and signs involving the circulatory and respiratory systems
0.732 0.268 0.000
N92.5 Other specified irregular menstruation
0.729 0.271 0.000
T23 Burn and corrosion of wrist and hand
0.728 0.272 0.000
T20 Burn and corrosion of head and neck
0.728 0.272 0.000
M40-M43 Deforming dorsopathies
0.727 0.273 0.000
N94.6 Dysmenorrhoea, unspecified
0.726 0.274 0.000
N86 Erosion and ectropion of cervix uteri
0.725 0.275 0.000
B80 Enterobiasis
0.724 0.276 0.000
M84.12 Nonunion of fracture [pseudarthrosis] (Upper arm)
0.723 0.277 0.000
Q51 Congenital malformations of uterus and cervix
0.723 0.277 0.000
S50 Superficial injury of forearm
0.722 0.278 0.000
H70 Mastoiditis and related conditions
0.722 0.278 0.000
S82 Fracture of lower leg, including ankle
0.718 0.282 0.000
R85 Abnormal findings in specimens from digestive organs and abdominal cavity
0.717 0.283 0.000
I25.6 Silent myocardial ischaemia
0.717 0.283 0.000
N98 Complications associated with artificial fertilisation
0.717 0.283 0.000
N96 Habitual aborter
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.716 0.284 0.000
N92.2 Excessive menstruation at puberty
0.715 0.285 0.000
N81.0 Female urethrocele
0.715 0.285 0.000
T22 Burn and corrosion of shoulder and upper limb, except wrist and hand
0.714 0.286 0.000
R06.7 Sneezing
0.714 0.286 0.000
R06.3 Periodic breathing
0.714 0.286 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.713 0.287 0.000
S92 Fracture of foot, except ankle
0.710 0.290 0.000
R49.0 Dysphonia
0.710 0.290 0.000
B50-B64 Protozoal diseases
0.709 0.291 0.000
T33-T35 Frostbite
0.709 0.291 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.709 0.291 0.000
T00-T07 Injuries involving multiple body regions
0.709 0.291 0.000
N91 Absent, scanty and rare menstruation
0.709 0.291 0.000
R84 Abnormal findings in specimens from respiratory organs and thorax
0.709 0.291 0.000
N85.7 Haematometra
0.709 0.291 0.000
N85.5 Inversion of uterus
0.709 0.291 0.000
N85.3 Subinvolution of uterus
0.709 0.291 0.000
T91 Sequelae of injuries of neck and trunk
0.709 0.291 0.000
T92.5 Sequelae of injury of muscle and tendon of upper limb
0.709 0.291 0.000
Q80-Q89 Other congenital malformations
0.708 0.292 0.000
H74.0 Tympanosclerosis
0.706 0.294 0.000
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere
0.706 0.294 0.000
H68 Eustachian salpingitis and obstruction
0.706 0.294 0.000
H67 Otitis media in diseases classified elsewhere
0.706 0.294 0.000
M21.0 Valgus deformity, not elsewhere classified
0.705 0.295 0.000
M82 Osteoporosis in diseases classified elsewhere
0.705 0.295 0.000
N94.4 Primary dysmenorrhoea
0.703 0.296 0.000
B96 Other bacterial agents as the cause of diseases classified to other chapters
0.703 0.297 0.000
R89 Abnormal findings in specimens from other organs, systems and tissues
0.702 0.298 0.000
R83 Abnormal findings in cerebrospinal fluid
0.702 0.298 0.000
M21.1 Varus deformity, not elsewhere classified
0.700 0.300 0.000
R77 Other abnormalities of plasma proteins
0.700 0.300 0.000
S51 Open wound of forearm
0.700 0.300 0.000
H82 Vertiginous syndromes in diseases classified elsewhere
0.699 0.301 0.000
J38.4 Oedema of larynx
0.699 0.301 0.000
M67 Other disorders of synovium and tendon
0.698 0.302 0.000
N95.0 Postmenopausal bleeding
0.698 0.302 0.000
N89 Other noninflammatory disorders of vagina
0.697 0.302 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.697 0.303 0.000
S99 Other and unspecified injuries of ankle and foot
0.697 0.303 0.000
H73 Other disorders of tympanic membrane
0.695 0.305 0.000
S56 Injury of muscle and tendon at forearm level
0.694 0.306 0.000
S88 Traumatic amputation of lower leg
0.694 0.306 0.000
S87 Crushing injury of lower leg
0.694 0.306 0.000
S85 Injury of blood vessels at lower leg level
0.694 0.306 0.000
S84 Injury of nerves at lower leg level
0.694 0.306 0.000
R87.9 Unspecified abnormal finding
0.693 0.307 0.000
R87.8 Other abnormal findings
0.693 0.307 0.000
R87.7 Abnormal histological findings
0.693 0.307 0.000
R87.5 Abnormal microbiological findings
0.693 0.307 0.000
R87.4 Abnormal immunological findings
0.693 0.307 0.000
R87.3 Abnormal level of substances chiefly nonmedicinal as to source
0.693 0.307 0.000
R87.2 Abnormal level of other drugs, medicaments and biological substances
0.693 0.307 0.000
R87.1 Abnormal level of hormones
0.693 0.307 0.000
R87.0 Abnormal level of enzymes
0.693 0.307 0.000
B25 Cytomegaloviral disease
0.693 0.307 0.000
M25.83 Other specified joint disorders (Forearm)
0.693 0.307 0.000
J00-J06 Acute upper respiratory infections
0.693 0.307 0.000
Chapter XXII Codes for special purposes
0.693 0.307 0.000
M24.5 Contracture of joint
0.692 0.308 0.000
N25-N29 Other disorders of kidney and ureter
0.692 0.308 0.000
E83.4 Disorders of magnesium metabolism
0.692 0.308 0.000
N82 Fistulae involving female genital tract
0.690 0.309 0.000
S20-S29 Injuries to the thorax
0.689 0.310 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.689 0.311 0.000
M25.64 Stiffness of joint, not elsewhere classified (Hand)
0.688 0.312 0.000
M25.84 Other specified joint disorders (Hand)
0.688 0.312 0.000
H65.4 Other chronic nonsuppurative otitis media
0.687 0.313 0.000
M87.8 Other osteonecrosis
0.687 0.313 0.000
M84.0 Malunion of fracture
0.686 0.314 0.000
J35 Chronic diseases of tonsils and adenoids
0.685 0.315 0.000
H83.9 Disease of inner ear, unspecified
0.685 0.315 0.000
H83.8 Other specified diseases of inner ear
0.685 0.315 0.000
H83.3 Noise effects on inner ear
0.685 0.315 0.000
H83.2 Labyrinthine dysfunction
0.685 0.315 0.000
H83.1 Labyrinthine fistula
0.685 0.315 0.000
M24.86 Other specific joint derangements, not elsewhere classified (Lower leg)
0.685 0.315 0.000
M25.33 Other instability of joint (Forearm)
0.685 0.315 0.000
R06.1 Stridor
0.684 0.316 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.683 0.317 0.000
Q35-Q37 Cleft lip and cleft palate
0.683 0.317 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.683 0.317 0.000
H69 Other disorders of Eustachian tube
0.683 0.317 0.000
S70-S79 Injuries to the hip and thigh
0.683 0.317 0.000
T18 Foreign body in alimentary tract
0.683 0.317 0.000
M84.13 Nonunion of fracture [pseudarthrosis] (Forearm)
0.681 0.319 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.681 0.319 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.681 0.319 0.000
M33 Dermatopolymyositis
0.681 0.319 0.000
M30 Polyarteritis nodosa and related conditions
0.681 0.319 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.680 0.320 0.000
Q50 Congenital malformations of ovaries, Fallopian tubes and broad ligaments
0.678 0.322 0.000
M25.63 Stiffness of joint, not elsewhere classified (Forearm)
0.678 0.322 0.000
H81.2 Vestibular neuronitis
0.677 0.323 0.000
M00-M03 Infectious arthropathies
0.676 0.323 0.000
M25.2 Flail joint
0.676 0.324 0.000
M25.1 Fistula of joint
0.676 0.324 0.000
M25.0 Haemarthrosis
0.676 0.324 0.000
S53 Dislocation, sprain and strain of joints and ligaments of elbow
0.671 0.328 0.000
N85.6 Intra-uterine synechiae
0.671 0.329 0.000
Q54 Hypospadias
0.671 0.329 0.000
Chapter XX External causes of morbidity and mortality
0.671 0.329 0.000
M60-M63 Disorders of muscles
0.670 0.330 0.000
J20-J22 Other acute lower respiratory infections
0.670 0.330 0.000
T16 Foreign body in ear
0.669 0.330 0.000
I23 Certain current complications following acute myocardial infarction
0.668 0.332 0.000
M24.2 Disorder of ligament
0.668 0.332 0.000
N93.8 Other specified abnormal uterine and vaginal bleeding
0.668 0.332 0.000
T92.0 Sequelae of open wound of upper limb
0.667 0.333 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.666 0.334 0.000
R73.9 Hyperglycaemia, unspecified
0.665 0.335 0.000
S83.7 Injury to multiple structures of knee
0.665 0.335 0.000
S83.4 Sprain and strain involving (fibular)(tibial) collateral ligamnent of knee
0.665 0.335 0.000
S83.1 Dislocation of knee
0.665 0.335 0.000
S83.0 Dislocation of patella
0.665 0.335 0.000
J36 Peritonsillar abscess
0.664 0.336 0.000
N85.8 Other specified noninflammatory disorders of uterus
0.664 0.336 0.000
J38.7 Other diseases of larynx
0.664 0.336 0.000
T92.3 Sequelae of dislocation, sprain and strain of upper limb
0.663 0.337 0.000
M20 Acquired deformities of fingers and toes
0.663 0.337 0.000
N94.2 Vaginismus
0.663 0.337 0.000
N94.0 Mittelschmerz
0.663 0.337 0.000
H74.2 Discontinuity and dislocation of ear ossicles
0.663 0.337 0.000
H74.1 Adhesive middle ear disease
0.663 0.337 0.000
I05-I09 Chronic rheumatic heart diseases
0.662 0.338 0.000
S80.0 Contusion of knee
0.662 0.338 0.000
M83 Adult osteomalacia
0.661 0.339 0.000
B97 Viral agents as the cause of diseases classified to other chapters
0.661 0.339 0.000
S80.9 Superficial injury of lower leg, unspecified
0.660 0.340 0.000
B96.1 Klebsiella pneumoniae [K. pneumoniae] as the cause of diseases classified to other chapters
0.659 0.341 0.000
B99-B99 Other infectious diseases
0.659 0.341 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.659 0.341 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.659 0.341 0.000
A75-A79 Rickettsioses
0.659 0.341 0.000
A70-A74 Other diseases caused by chlamydiae
0.659 0.341 0.000
A65-A69 Other spirochaetal diseases
0.659 0.341 0.000
A20-A28 Certain zoonotic bacterial diseases
0.659 0.341 0.000
A15-A19 Tuberculosis
0.659 0.341 0.000
N87.9 Dysplasia of cervix uteri, unspecified
0.657 0.343 0.000
E83.5 Disorders of calcium metabolism
0.657 0.343 0.000
Chapter VI Diseases of the nervous system
0.656 0.344 0.000
H72 Perforation of tympanic membrane
0.656 0.344 0.000
H92 Otalgia and effusion of ear
0.656 0.344 0.000
M86 Osteomyelitis
0.655 0.345 0.000
J38.1 Polyp of vocal cord and larynx
0.654 0.346 0.000
H66.4 Suppurative otitis media, unspecified
0.653 0.347 0.000
H66.2 Chronic atticoantral suppurative otitis media
0.653 0.347 0.000
H66.1 Chronic tubotympanic suppurative otitis media
0.653 0.347 0.000
H66.0 Acute suppurative otitis media
0.653 0.347 0.000
R78 Findings of drugs and other substances, not normally found in blood
0.652 0.348 0.000
R70 Elevated erythrocyte sedimentation rate and abnormality of plasma viscosity
0.652 0.348 0.000
R75 Laboratory evidence of human immunodeficiency virus [HIV]
0.652 0.348 0.000
M84.9 Disorder of continuity of bone, unspecified
0.651 0.348 0.000
M84.8 Other disorders of continuity of bone
0.651 0.348 0.000
M84.4 Pathological fracture, not elsewhere classified
0.651 0.348 0.000
M84.3 Stress fracture, not elsewhere classified
0.651 0.348 0.000
M84.2 Delayed union of fracture
0.651 0.348 0.000
M25.85 Other specified joint disorders (Pelvic region and thigh)
0.650 0.350 0.000
H65.9 Nonsuppurative otitis media, unspecified
0.649 0.351 0.000
M25.89 Other specified joint disorders (Site unspecified)
0.649 0.351 0.000
M25.88 Other specified joint disorders (Other)
0.649 0.351 0.000
M25.82 Other specified joint disorders (Upper arm)
0.649 0.351 0.000
M25.80 Other specified joint disorders (Multiple sites)
0.649 0.351 0.000
H74.3 Other acquired abnormalities of ear ossicles
0.649 0.351 0.000
Q23 Congenital malformations of aortic and mitral valves
0.648 0.352 0.000
N40-N51 Diseases of male genital organs
0.646 0.354 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.645 0.355 0.000
S81.8 Open wound of other parts of lower leg
0.645 0.355 0.000
Q60-Q64 Congenital malformations of the urinary system
0.645 0.355 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.644 0.356 0.000
M25.9 Joint disorder, unspecified
0.643 0.356 0.000
M84.19 Nonunion of fracture [pseudarthrosis] (Site unspecified)
0.643 0.357 0.000
M84.18 Nonunion of fracture [pseudarthrosis] (Other)
0.643 0.357 0.000
M84.14 Nonunion of fracture [pseudarthrosis] (Hand)
0.643 0.357 0.000
M84.10 Nonunion of fracture [pseudarthrosis] (Multiple sites)
0.643 0.357 0.000
N92.3 Ovulation bleeding
0.643 0.357 0.000
M20.2 Hallux rigidus
0.643 0.357 0.000
H81.0 Meniere's disease
0.643 0.357 0.000
M91-M94 Chondropathies
0.642 0.358 0.000
J00 Acute nasopharyngitis [common cold]
0.641 0.359 0.000
R09.1 Pleurisy
0.640 0.360 0.000
M87.95 Osteonecrosis, unspecified (Pelvic region and thigh)
0.640 0.360 0.000
T95 Sequelae of burns, corrosions and frostbite
0.639 0.361 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.639 0.361 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.639 0.361 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.639 0.361 0.000
B25.9 Cytomegaloviral disease, unspecified
0.639 0.361 0.000
T25 Burn and corrosion of ankle and foot
0.637 0.362 0.000
T24 Burn and corrosion of hip and lower limb, except ankle and foot
0.637 0.362 0.000
T21 Burn and corrosion of trunk
0.637 0.362 0.000
R76 Other abnormal immunological findings in serum
0.637 0.363 0.000
S13 Dislocation, sprain and strain of joints and ligaments at neck level
0.635 0.365 0.000
S83.5 Sprain and strain involving (anterior)(posterior) cruciate ligament of knee
0.634 0.366 0.000
B96.4 Proteus (mirabilis)(morganii) as the cause of diseases classified to other chapters
0.634 0.366 0.000
R01.0 Benign and innocent cardiac murmurs
0.633 0.366 0.000
H61 Other disorders of external ear
0.632 0.368 0.000
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)
0.632 0.368 0.000
T78 Adverse effects, not elsewhere classified
0.632 0.368 0.000
S12 Fracture of neck
0.631 0.369 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.630 0.370 0.000
R01.2 Other cardiac sounds
0.630 0.370 0.000
S82.6 Fracture of lateral malleolus
0.629 0.370 0.000
Q51.3 Bicornate uterus
0.629 0.371 0.000
N99-N99 Other disorders of the genitourinary system
0.629 0.371 0.000
S59 Other and unspecified injuries of forearm
0.629 0.371 0.000
S58 Traumatic amputation of forearm
0.629 0.371 0.000
S57 Crushing injury of forearm
0.629 0.371 0.000
S55 Injury of blood vessels at forearm level
0.629 0.371 0.000
S54 Injury of nerves at forearm level
0.629 0.371 0.000
I00-I02 Acute rheumatic fever
0.629 0.371 0.000
S40-S49 Injuries to the shoulder and upper arm
0.628 0.371 0.000
N85.9 Noninflammatory disorder of uterus, unspecified
0.628 0.372 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.628 0.372 0.000
M25.58 Pain in joint (Other)
0.627 0.372 0.000
H60 Otitis externa
0.627 0.373 0.000
A63 Other predominantly sexually transmitted diseases, not elsewhere classified
0.626 0.374 0.000
M24.85 Other specific joint derangements, not elsewhere classified (Pelvic region and thigh)
0.626 0.374 0.000
Q27 Other congenital malformations of peripheral vascular system
0.625 0.375 0.000
A80-A89 Viral infections of the central nervous system
0.625 0.375 0.000
B15 Acute hepatitis A
0.624 0.376 0.000
M67.8 Other specified disorders of synovium and tendon
0.623 0.377 0.000
H91 Other hearing loss
0.622 0.378 0.000
S89 Other and unspecified injuries of lower leg
0.621 0.379 0.000
R06.2 Wheezing
0.621 0.379 0.000
T90 Sequelae of injuries of head
0.620 0.380 0.000
S22 Fracture of rib(s), sternum and thoracic spine
0.618 0.382 0.000
M22 Disorders of patella
0.617 0.383 0.000
M87.97 Osteonecrosis, unspecified (Ankle and foot)
0.617 0.383 0.000
M34 Systemic sclerosis
0.617 0.383 0.000
M21.4 Flat foot [pes planus] (acquired)
0.617 0.383 0.000
M21.16 Varus deformity, not elsewhere classified (Lower leg)
0.616 0.384 0.000
M24.9 Joint derangement, unspecified
0.615 0.385 0.000
M24.7 Protrusio acetabuli
0.615 0.385 0.000
M24.6 Ankylosis of joint
0.615 0.385 0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified
0.615 0.385 0.000
T23.2 Burn of second degree of wrist and hand
0.613 0.387 0.000
Q56 Indeterminate sex and pseudohermaphroditism
0.612 0.388 0.000
Q55 Other congenital malformations of male genital organs
0.612 0.388 0.000
Q53 Undescended testicle
0.612 0.388 0.000
Q52 Other congenital malformations of female genitalia
0.612 0.388 0.000
R22 Localised swelling, mass and lump of skin and subcutaneous tissue
0.612 0.388 0.000
N95.9 Menopausal and perimenopausal disorder, unspecified
0.609 0.391 0.000
S86.8 Injury of other muscles and tendons at lower leg level
0.608 0.391 0.000
M20.6 Acquired deformity of toe(s), unspecified
0.608 0.392 0.000
M21.06 Valgus deformity, not elsewhere classified (Lower leg)
0.608 0.392 0.000
B97.8 Other viral agents as the cause of diseases classified to other chapters
0.607 0.393 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.607 0.393 0.000
T92.6 Sequelae of crushing injury and traumatic amputation of upper limb
0.606 0.394 0.000
T92.4 Sequelae of injury of nerve of upper limb
0.606 0.394 0.000
S90 Superficial injury of ankle and foot
0.606 0.394 0.000
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level
0.606 0.394 0.000
Q24 Other congenital malformations of heart
0.606 0.394 0.000
M25.61 Stiffness of joint, not elsewhere classified (Shoulder region)
0.605 0.394 0.000
T92.8 Sequelae of other specified injuries of upper limb
0.604 0.396 0.000
R06.4 Hyperventilation
0.603 0.397 0.000
R71 Abnormality of red blood cells
0.603 0.397 0.000
S98 Traumatic amputation of ankle and foot
0.602 0.398 0.000
S97 Crushing injury of ankle and foot
0.602 0.398 0.000
S96 Injury of muscle and tendon at ankle and foot level
0.602 0.398 0.000
S95 Injury of blood vessels at ankle and foot level
0.602 0.398 0.000
S94 Injury of nerves at ankle and foot level
0.602 0.398 0.000
N81.2 Incomplete uterovaginal prolapse
0.602 0.398 0.000
T92.9 Sequelae of unspecified injury of upper limb
0.601 0.399 0.000
N95.1 Menopausal and female climacteric states
0.600 0.400 0.000
T92.1 Sequelae of fracture of arm
0.600 0.400 0.000
M32.1 Systemic lupus erythematosus with organ or system involvement
0.599 0.400 0.000
G35 Multiple sclerosis
0.600 0.400 0.000
T19 Foreign body in genito-urinary tract
0.599 0.401 0.000
T15 Foreign body on external eye
0.599 0.401 0.000
M24.1 Other articular cartilage disorders
0.599 0.401 0.000
N80 Endometriosis
0.599 0.401 0.000
S31 Open wound of abdomen, lower back and pelvis
0.599 0.401 0.000
T98 Sequelae of other and unspecified effects of external causes
0.598 0.402 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.598 0.402 0.000
M25.69 Stiffness of joint, not elsewhere classified (Site unspecified)
0.597 0.403 0.000
M25.68 Stiffness of joint, not elsewhere classified (Other)
0.597 0.403 0.000
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)
0.597 0.403 0.000
M25.65 Stiffness of joint, not elsewhere classified (Pelvic region and thigh)
0.597 0.403 0.000
M25.62 Stiffness of joint, not elsewhere classified (Upper arm)
0.597 0.403 0.000
M25.60 Stiffness of joint, not elsewhere classified (Multiple sites)
0.597 0.403 0.000
T91.3 Sequelae of injury of spinal cord
0.597 0.403 0.000
H81.1 Benign paroxysmal vertigo
0.597 0.403 0.000
N89.5 Stricture and atresia of vagina
0.597 0.403 0.000
S92.0 Fracture of calcaneus
0.597 0.403 0.000
Q07 Other congenital malformations of nervous system
0.596 0.404 0.000
S50.0 Contusion of elbow
0.595 0.404 0.000
J95-J99 Other diseases of the respiratory system
0.595 0.405 0.000
J38.6 Stenosis of larynx
0.595 0.405 0.000
S99.9 Unspecified injury of ankle and foot
0.595 0.405 0.000
T17 Foreign body in respiratory tract
0.594 0.406 0.000
R04.9 Haemorrhage from respiratory passages, unspecified
0.593 0.407 0.000
R04.8 Haemorrhage from other sites in respiratory passages
0.593 0.407 0.000
R04.1 Haemorrhage from throat
0.593 0.407 0.000
S71 Open wound of hip and thigh
0.592 0.408 0.000
M80 Osteoporosis with pathological fracture
0.592 0.408 0.000
N10-N16 Renal tubulo-interstitial diseases
0.592 0.408 0.000
S82.0 Fracture of patella
0.592 0.408 0.000
R49.8 Other and unspecified voice disturbances
0.592 0.408 0.000
M87.85 Other osteonecrosis (Pelvic region and thigh)
0.591 0.409 0.000
M89.3 Hypertrophy of bone
0.591 0.409 0.000
A00-A09 Intestinal infectious diseases
0.591 0.409 0.000
H81.9 Disorder of vestibular function, unspecified
0.590 0.410 0.000
H81.8 Other disorders of vestibular function
0.590 0.410 0.000
H81.4 Vertigo of central origin
0.590 0.410 0.000
H81.3 Other peripheral vertigo
0.590 0.410 0.000
B18 Chronic viral hepatitis
0.589 0.411 0.000
T22.2 Burn of second degree of shoulder and upper limb, except wrist and hand
0.589 0.411 0.000
M66 Spontaneous rupture of synovium and tendon
0.589 0.411 0.000
M89.0 Algoneurodystrophy
0.588 0.411 0.000
M87.3 Other secondary osteonecrosis
0.588 0.412 0.000
M87.1 Osteonecrosis due to drugs
0.588 0.412 0.000
M87.0 Idiopathic aseptic necrosis of bone
0.588 0.412 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.588 0.412 0.000
T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
0.588 0.412 0.000
M88 Paget's disease of bone [osteitis deformans]
0.588 0.412 0.000
Q21 Congenital malformations of cardiac septa
0.587 0.412 0.000
T75 Effects of other external causes
0.587 0.413 0.000
M21.9 Acquired deformity of limb, unspecified
0.587 0.413 0.000
M21.8 Other specified acquired deformities of limbs
0.587 0.413 0.000
M21.7 Unequal limb length (acquired)
0.587 0.413 0.000
S51.7 Multiple open wounds of forearm
0.586 0.414 0.000
N81.9 Female genital prolapse, unspecified
0.586 0.414 0.000
R48 Dyslexia and other symbolic dysfunctions, not elsewhere classified
0.586 0.414 0.000
M89.5 Osteolysis
0.585 0.415 0.000
M25.59 Pain in joint (Site unspecified)
0.584 0.416 0.000
T86 Failure and rejection of transplanted organs and tissues
0.580 0.420 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.580 0.420 0.000
S52 Fracture of forearm
0.579 0.421 0.000
T31 Burns classified according to extent of body surface involved
0.579 0.421 0.000
M35 Other systemic involvement of connective tissue
0.578 0.421 0.000
J40-J47 Chronic lower respiratory diseases
0.578 0.422 0.000
M87.2 Osteonecrosis due to previous trauma
0.578 0.422 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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