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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs8043227
log Bayes Factor = 23.5612
Chromosome 15   position 78,768,871  (GRCh37) Explore rs8043227 on Ensembl!
Variant rs8043227 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
J44.9 Chronic obstructive pulmonary disease, unspecified
1.000 0.000 0.000
J44 Other chronic obstructive pulmonary disease
1.000 0.000 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
1.000 0.000 0.000
J43.9 Emphysema, unspecified
1.000 0.000 0.000
J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection
1.000 0.000 0.000
I71 Aortic aneurysm and dissection
1.000 0.000 0.000
J43 Emphysema
1.000 0.000 0.000
J40-J47 Chronic lower respiratory diseases
1.000 0.000 0.000
I60-I69 Cerebrovascular diseases
0.999 0.001 0.000
I69 Sequelae of cerebrovascular disease
0.998 0.002 0.000
J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified
0.997 0.003 0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.996 0.004 0.000
I70 Atherosclerosis
0.994 0.006 0.000
Chapter IX Diseases of the circulatory system
0.993 0.007 0.000
I69.3 Sequelae of cerebral infarction
0.992 0.008 0.000
I77 Other disorders of arteries and arterioles
0.991 0.009 0.000
I73 Other peripheral vascular diseases
0.987 0.013 0.000
I70.2 Atherosclerosis of arteries of the extremities
0.987 0.013 0.000
I70.20 Atherosclerosis of arteries of extremities (without gangrene)
0.983 0.017 0.000
I73.9 Peripheral vascular disease, unspecified
0.982 0.018 0.000
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction
0.974 0.026 0.000
I64 Stroke, not specified as haemorrhage or infarction
0.970 0.030 0.000
I60 Subarachnoid haemorrhage
0.967 0.033 0.000
I77.9 Disorder of arteries and arterioles, unspecified
0.962 0.038 0.000
I67 Other cerebrovascular diseases
0.962 0.038 0.000
I77.1 Stricture of artery
0.955 0.045 0.000
Chapter X Diseases of the respiratory system
0.953 0.047 0.000
J90-J94 Other diseases of pleura
0.953 0.047 0.000
J93 Pneumothorax
0.950 0.050 0.000
J92 Pleural plaque
0.940 0.060 0.000
J93.9 Pneumothorax, unspecified
0.935 0.065 0.000
J92.0 Pleural plaque with presence of asbestos
0.932 0.068 0.000
I67.1 Cerebral aneurysm, nonruptured
0.932 0.068 0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.930 0.070 0.000
I69.0 Sequelae of subarachnoid haemorrhage
0.927 0.073 0.000
K70 Alcoholic liver disease
0.906 0.094 0.000
K70.3 Alcoholic cirrhosis of liver
0.903 0.097 0.000
I67.9 Cerebrovascular disease, unspecified
0.899 0.101 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.894 0.106 0.000
K70.9 Alcoholic liver disease, unspecified
0.888 0.112 0.000
J93.1 Other spontaneous pneumothorax
0.879 0.121 0.000
C34 Malignant neoplasm of bronchus and lung
0.873 0.127 0.000
J60-J70 Lung diseases due to external agents
0.871 0.129 0.000
C34.1 Upper lobe, bronchus or lung
0.869 0.131 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.869 0.131 0.000
J86 Pyothorax
0.862 0.138 0.000
J42 Unspecified chronic bronchitis
0.858 0.142 0.000
C32 Malignant neoplasm of larynx
0.852 0.148 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.851 0.149 0.000
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.845 0.154 0.000
C32.0 Glottis
0.842 0.158 0.000
J86.9 Pyothorax without fistula
0.839 0.161 0.000
I70.8 Atherosclerosis of other arteries
0.833 0.167 0.000
K70-K77 Diseases of liver
0.830 0.170 0.000
I60.7 Subarachnoid haemorrhage from intracranial artery, unspecified
0.830 0.170 0.000
I98 Other disorders of circulatory system in diseases classified elsewhere
0.829 0.171 0.000
I60.2 Subarachnoid haemorrhage from anterior communicating artery
0.825 0.175 0.000
I60.8 Other subarachnoid haemorrhage
0.819 0.181 0.000
C34.9 Bronchus or lung, unspecified
0.819 0.181 0.000
J95-J99 Other diseases of the respiratory system
0.818 0.182 0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.818 0.182 0.000
I60.9 Subarachnoid haemorrhage, unspecified
0.816 0.184 0.000
I71.3 Abdominal aortic aneurysm, ruptured
0.806 0.194 0.000
I73.1 Thromboangiitis obliterans [Buerger]
0.802 0.198 0.000
C32.9 Larynx, unspecified
0.798 0.202 0.000
C34.3 Lower lobe, bronchus or lung
0.797 0.203 0.000
C34.2 Middle lobe, bronchus or lung
0.794 0.206 0.000
I71.1 Thoracic aortic aneurysm, ruptured
0.790 0.210 0.000
K73 Chronic hepatitis, not elsewhere classified
0.786 0.214 0.000
I78 Diseases of capillaries
0.786 0.214 0.000
J43.2 Centrilobular emphysema
0.785 0.215 0.000
I98.2 Oesophageal varices in diseases classified elsewhere
0.783 0.217 0.000
I77.2 Rupture of artery
0.779 0.221 0.000
J61 Pneumoconiosis due to asbestos and other mineral fibres
0.778 0.222 0.000
K70.1 Alcoholic hepatitis
0.778 0.222 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.775 0.224 0.000
I05-I09 Chronic rheumatic heart diseases
0.773 0.227 0.000
I60.1 Subarachnoid haemorrhage from middle cerebral artery
0.770 0.230 0.000
J93.8 Other pneumothorax
0.766 0.234 0.000
I74 Arterial embolism and thrombosis
0.763 0.237 0.000
K70.2 Alcoholic fibrosis and sclerosis of liver
0.762 0.238 0.000
J98 Other respiratory disorders
0.760 0.240 0.000
K73.9 Chronic hepatitis, unspecified
0.742 0.258 0.000
K70.4 Alcoholic hepatic failure
0.740 0.260 0.000
J93.0 Spontaneous tension pneumothorax
0.740 0.260 0.000
J60 Coalworker's pneumoconiosis
0.738 0.262 0.000
I63 Cerebral infarction
0.737 0.263 0.000
I60.3 Subarachnoid haemorrhage from posterior communicating artery
0.732 0.268 0.000
I70.80 Atherosclerosis of other arteries (without gangrene)
0.718 0.282 0.000
I77.0 Arteriovenous fistula, acquired
0.717 0.283 0.000
I71.8 Aortic aneurysm of unspecified site, ruptured
0.717 0.283 0.000
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.717 0.283 0.000
J43.1 Panlobular emphysema
0.717 0.283 0.000
J43.0 MacLeod's syndrome
0.717 0.283 0.000
J64 Unspecified pneumoconiosis
0.714 0.286 0.000
I67.0 Dissection of cerebral arteries, nonruptured
0.712 0.288 0.000
J98.0 Diseases of bronchus, not elsewhere classified
0.712 0.288 0.000
J98.4 Other disorders of lung
0.711 0.289 0.000
I77.5 Necrosis of artery
0.710 0.290 0.000
I77.4 Coeliac artery compression syndrome
0.710 0.290 0.000
K70.0 Alcoholic fatty liver
0.709 0.291 0.000
I70.0 Atherosclerosis of aorta
0.708 0.292 0.000
I67.7 Cerebral arteritis, not elsewhere classified
0.708 0.292 0.000
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.707 0.293 0.000
I06 Rheumatic aortic valve diseases
0.707 0.293 0.000
I78.0 Hereditary haemorrhagic telangiectasia
0.707 0.293 0.000
I70.9 Generalised and unspecified atherosclerosis
0.706 0.294 0.000
I63.5 Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
0.702 0.298 0.000
I70.1 Atherosclerosis of renal artery
0.699 0.301 0.000
I67.6 Nonpyogenic thrombosis of intracranial venous system
0.699 0.301 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.697 0.303 0.000
I60.5 Subarachnoid haemorrhage from vertebral artery
0.693 0.306 0.000
J94 Other pleural conditions
0.693 0.307 0.000
I69.2 Sequelae of other nontraumatic intracranial haemorrhage
0.692 0.308 0.000
C32.1 Supraglottis
0.691 0.308 0.000
I67.5 Moyamoya disease
0.690 0.310 0.000
I67.4 Hypertensive encephalopathy
0.690 0.310 0.000
I67.3 Progressive vascular leukoencephalopathy
0.690 0.310 0.000
J46 Status asthmaticus
0.688 0.312 0.000
K76 Other diseases of liver
0.687 0.313 0.000
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere
0.683 0.317 0.000
C33 Malignant neoplasm of trachea
0.679 0.321 0.000
K76.6 Portal hypertension
0.677 0.323 0.000
K71 Toxic liver disease
0.675 0.325 0.000
I60.4 Subarachnoid haemorrhage from basilar artery
0.674 0.326 0.000
I60.0 Subarachnoid haemorrhage from carotid siphon and bifurcation
0.674 0.326 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.672 0.328 0.000
I69.1 Sequelae of intracerebral haemorrhage
0.671 0.329 0.000
K73.2 Chronic active hepatitis, not elsewhere classified
0.668 0.332 0.000
J69 Pneumonitis due to solids and liquids
0.661 0.339 0.000
I09 Other rheumatic heart diseases
0.660 0.340 0.000
J43.8 Other emphysema
0.659 0.341 0.000
J41 Simple and mucopurulent chronic bronchitis
0.658 0.342 0.000
I77.8 Other specified disorders of arteries and arterioles
0.658 0.342 0.000
I70.21 Atherosclerosis of arteries of extremities (with gangrene)
0.656 0.344 0.000
K77 Liver disorders in diseases classified elsewhere
0.655 0.345 0.000
K74 Fibrosis and cirrhosis of liver
0.648 0.352 0.000
I74.9 Embolism and thrombosis of unspecified artery
0.642 0.358 0.000
J92.9 Pleural plaque without asbestos
0.642 0.358 0.000
J62 Pneumoconiosis due to dust containing silica
0.636 0.364 0.000
I00-I02 Acute rheumatic fever
0.632 0.367 0.000
J68 Respiratory conditions due to inhalation of chemicals, gases, fumes and vapours
0.624 0.376 0.000
J66 Airway disease due to specific organic dust
0.624 0.376 0.000
J63 Pneumoconiosis due to other inorganic dusts
0.624 0.376 0.000
J65 Pneumoconiosis associated with tuberculosis
0.624 0.376 0.000
I95 Hypotension
0.617 0.382 0.000
J86.0 Pyothorax with fistula
0.616 0.384 0.000
I68.0 Cerebral amyloid angiopathy
0.615 0.384 0.000
K72 Hepatic failure, not elsewhere classified
0.615 0.385 0.000
I71.0 Dissection of aorta [any part]
0.613 0.387 0.000
C32.8 Overlapping lesion of larynx
0.611 0.389 0.000
C32.3 Laryngeal cartilage
0.611 0.389 0.000
C32.2 Subglottis
0.611 0.389 0.000
C39 Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs
0.610 0.390 0.000
J99 Respiratory disorders in diseases classified elsewhere
0.610 0.390 0.000
I77.3 Arterial fibromuscular dysplasia
0.609 0.391 0.000
I06.1 Rheumatic aortic insufficiency
0.607 0.393 0.000
K74.6 Other and unspecified cirrhosis of liver
0.600 0.400 0.000
C34.8 Overlapping lesion of bronchus and lung
0.598 0.402 0.000
I70.81 Atherosclerosis of other arteries (with gangrene)
0.597 0.403 0.000
C38 Malignant neoplasm of heart, mediastinum and pleura
0.595 0.405 0.000
I98.8 Other specified disorders of circulatory system in diseases classified elsewhere
0.594 0.406 0.000
I98.1 Cardiovascular disorders in other infectious and parasitic diseases classified elsewhere
0.594 0.406 0.000
I98.0 Cardiovascular syphilis
0.594 0.406 0.000
J94.1 Fibrothorax
0.593 0.407 0.000
J69.8 Pneumonitis due to other solids and liquids
0.589 0.411 0.000
J96 Respiratory failure, not elsewhere classified
0.586 0.413 0.000
C30 Malignant neoplasm of nasal cavity and middle ear
0.584 0.416 0.000
I73.0 Raynaud's syndrome
0.580 0.420 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.579 0.420 0.000
I09.9 Rheumatic heart disease, unspecified
0.579 0.420 0.000
I63.0 Cerebral infarction due to thrombosis of precerebral arteries
0.576 0.424 0.000
J98.9 Respiratory disorder, unspecified
0.574 0.426 0.000
I06.2 Rheumatic aortic stenosis with insufficiency
0.571 0.429 0.000
I63.2 Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
0.569 0.431 0.000
K73.1 Chronic lobular hepatitis, not elsewhere classified
0.564 0.436 0.000
K73.0 Chronic persistent hepatitis, not elsewhere classified
0.564 0.436 0.000
J85 Abscess of lung and mediastinum
0.560 0.439 0.000
I95.9 Hypotension, unspecified
0.560 0.440 0.000
J94.9 Pleural condition, unspecified
0.558 0.442 0.000
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.557 0.443 0.000
I60.6 Subarachnoid haemorrhage from other intracranial arteries
0.556 0.443 0.000
I68.8 Other cerebrovascular disorders in diseases classified elsewhere
0.556 0.444 0.000
I68.2 Cerebral arteritis in other diseases classified elsewhere
0.556 0.444 0.000
I68.1 Cerebral arteritis in infectious and parasitic diseases classified elsewhere
0.556 0.444 0.000
I06.0 Rheumatic aortic stenosis
0.556 0.444 0.000
I63.4 Cerebral infarction due to embolism of cerebral arteries
0.554 0.446 0.000
I77.6 Arteritis, unspecified
0.554 0.446 0.000
K76.7 Hepatorenal syndrome
0.550 0.450 0.000
J98.1 Pulmonary collapse
0.549 0.451 0.000
J98.3 Compensatory emphysema
0.545 0.455 0.000
I74.0 Embolism and thrombosis of abdominal aorta
0.543 0.457 0.000
I78.9 Disease of capillaries, unspecified
0.538 0.462 0.000
J70 Respiratory conditions due to other external agents
0.538 0.462 0.000
I05 Rheumatic mitral valve diseases
0.536 0.464 0.000
I28 Other diseases of pulmonary vessels
0.534 0.466 0.000
I63.6 Cerebral infarction due to cerebral venous thrombosis, nonpyogenic
0.528 0.471 0.000
I63.1 Cerebral infarction due to embolism of precerebral arteries
0.528 0.471 0.000
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.528 0.471 0.000
I78.8 Other diseases of capillaries
0.524 0.476 0.000
I06.9 Rheumatic aortic valve disease, unspecified
0.523 0.477 0.000
K71.9 Toxic liver disease, unspecified
0.519 0.480 0.000
C31 Malignant neoplasm of accessory sinuses
0.516 0.484 0.000
J98.2 Interstitial emphysema
0.516 0.484 0.000
K77.0 Liver disorders in infectious and parasitic diseases classified elsewhere
0.514 0.486 0.000
K71.0 Toxic liver disease with cholestasis
0.514 0.486 0.000
K71.6 Toxic liver disease with hepatitis, not elsewhere classified
0.511 0.489 0.000
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.511 0.489 0.000
I70.01 Atherosclerosis of aorta (with gangrene)
0.508 0.492 0.000
I06.8 Other rheumatic aortic valve diseases
0.507 0.493 0.000
I70.91 Generalized and unspecified atherosclerosis (with gangrene)
0.506 0.494 0.000
C34.0 Main bronchus
0.506 0.494 0.000
K74.5 Biliary cirrhosis, unspecified
0.505 0.495 0.000
K72.9 Hepatic failure, unspecified
0.504 0.496 0.000
I70.00 Atherosclerosis of aorta (without gangrene)
0.504 0.496 0.000
I70.11 Atherosclerosis of renal artery (with gangrene)
0.501 0.498 0.000
J99.0 Rheumatoid lung disease
0.501 0.499 0.000
I70.90 Generalized and unspecified atherosclerosis (without gangrene)
0.500 0.500 0.000
J94.0 Chylous effusion
0.497 0.503 0.000
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.493 0.507 0.000
K76.5 Hepatic veno-occlusive disease
0.493 0.507 0.000
K76.4 Peliosis hepatis
0.493 0.507 0.000
K76.3 Infarction of liver
0.493 0.507 0.000
K76.2 Central haemorrhagic necrosis of liver
0.493 0.507 0.000
I07 Rheumatic tricuspid valve diseases
0.492 0.508 0.000
K73.8 Other chronic hepatitis, not elsewhere classified
0.491 0.508 0.000
I67.2 Cerebral atherosclerosis
0.490 0.510 0.000
K77.8 Liver disorders in other diseases classified elsewhere
0.489 0.511 0.000
I70.10 Atherosclerosis of renal artery (without gangrene)
0.488 0.512 0.000
I26 Pulmonary embolism
0.488 0.512 0.000
K71.1 Toxic liver disease with hepatic necrosis
0.486 0.514 0.000
I99 Other and unspecified disorders of circulatory system
0.486 0.514 0.000
K71.8 Toxic liver disease with other disorders of liver
0.484 0.516 0.000
K71.7 Toxic liver disease with fibrosis and cirrhosis of liver
0.484 0.516 0.000
K71.5 Toxic liver disease with chronic active hepatitis
0.484 0.516 0.000
K71.4 Toxic liver disease with chronic lobular hepatitis
0.484 0.516 0.000
K71.3 Toxic liver disease with chronic persistent hepatitis
0.484 0.516 0.000
K71.2 Toxic liver disease with acute hepatitis
0.484 0.516 0.000
I79.1 Aortitis in diseases classified elsewhere
0.482 0.518 0.000
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.482 0.518 0.000
K74.1 Hepatic sclerosis
0.475 0.525 0.000
J69.1 Pneumonitis due to oils and essences
0.474 0.526 0.000
I09.8 Other specified rheumatic heart diseases
0.474 0.526 0.000
I09.2 Chronic rheumatic pericarditis
0.474 0.526 0.000
I09.1 Rheumatic diseases of endocardium, valve unspecified
0.474 0.526 0.000
I09.0 Rheumatic myocarditis
0.474 0.526 0.000
J41.8 Mixed simple and mucopurulent chronic bronchitis
0.472 0.528 0.000
J41.1 Mucopurulent chronic bronchitis
0.472 0.528 0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.471 0.528 0.000
I95.8 Other hypotension
0.471 0.529 0.000
I46.0 Cardiac arrest with successful resuscitation
0.470 0.530 0.000
I69.8 Sequelae of other and unspecified cerebrovascular diseases
0.469 0.531 0.000
J62.8 Pneumoconiosis due to other dust containing silica
0.467 0.532 0.000
J98.6 Disorders of diaphragm
0.467 0.532 0.000
K74.4 Secondary biliary cirrhosis
0.465 0.535 0.000
K74.2 Hepatic fibrosis with hepatic sclerosis
0.465 0.535 0.000
I46 Cardiac arrest
0.462 0.538 0.000
I62 Other nontraumatic intracranial haemorrhage
0.461 0.539 0.000
J62.0 Pneumoconiosis due to talc dust
0.456 0.544 0.000
I27 Other pulmonary heart diseases
0.454 0.546 0.000
I78.1 Naevus, nonneoplastic
0.454 0.546 0.000
I02 Rheumatic chorea
0.453 0.546 0.000
I01 Rheumatic fever with heart involvement
0.453 0.546 0.000
J67 Hypersensitivity pneumonitis due to organic dust
0.453 0.547 0.000
I74.8 Embolism and thrombosis of other arteries
0.451 0.549 0.000
J63.8 Pneumoconiosis due to other specified inorganic dusts
0.448 0.552 0.000
J63.5 Stannosis
0.448 0.552 0.000
J63.4 Siderosis
0.448 0.552 0.000
J63.3 Graphite fibrosis (of lung)
0.448 0.552 0.000
J63.2 Berylliosis
0.448 0.552 0.000
J63.1 Bauxite fibrosis (of lung)
0.448 0.552 0.000
J63.0 Aluminosis (of lung)
0.448 0.552 0.000
J66.8 Airway disease due to other specific organic dusts
0.448 0.552 0.000
J66.2 Cannabinosis
0.448 0.552 0.000
J66.1 Flax-dresser's disease
0.448 0.552 0.000
J66.0 Byssinosis
0.448 0.552 0.000
J68.9 Unspecified respiratory condition due to chemicals, gases, fumes and vapours
0.448 0.552 0.000
J68.8 Other respiratory conditions due to chemicals, gases, fumes and vapours
0.448 0.552 0.000
J68.4 Chronic respiratory conditions due to chemicals, gases, fumes and vapours
0.448 0.552 0.000
J68.3 Other acute and subacute respiratory conditions due to chemicals, gases, fumes and vapours
0.448 0.552 0.000
J68.2 Upper respiratory inflammation due to chemicals, gases, fumes and vapours, not elsewhere classified
0.448 0.552 0.000
J68.1 Acute pulmonary oedema due to chemicals, gases, fumes and vapours
0.448 0.552 0.000
J68.0 Bronchitis and pneumonitis due to chemicals, gases, fumes and vapours
0.448 0.552 0.000
J98.5 Diseases of mediastinum, not elsewhere classified
0.447 0.553 0.000
I66.4 Occlusion and stenosis of multiple and bilateral cerebral arteries
0.447 0.553 0.000
C38.3 Mediastinum, part unspecified
0.447 0.553 0.000
K75 Other inflammatory liver diseases
0.447 0.553 0.000
I30-I52 Other forms of heart disease
0.447 0.553 0.000
K76.1 Chronic passive congestion of liver
0.445 0.555 0.000
I05.0 Mitral stenosis
0.444 0.555 0.000
I73.8 Other specified peripheral vascular diseases
0.443 0.556 0.001
K72.1 Chronic hepatic failure
0.439 0.561 0.000
C39.9 Ill-defined sites within the respiratory system
0.437 0.562 0.000
C39.8 Overlapping lesion of respiratory and intrathoracic organs
0.437 0.562 0.000
C39.0 Upper respiratory tract, part unspecified
0.437 0.562 0.000
J44.8 Other specified chronic obstructive pulmonary disease
0.435 0.565 0.000
J94.8 Other specified pleural conditions
0.431 0.569 0.000
I28.9 Disease of pulmonary vessels, unspecified
0.428 0.572 0.000
C37 Malignant neoplasm of thymus
0.427 0.572 0.001
C38.8 Overlapping lesion of heart, mediastinum and pleura
0.427 0.573 0.000
C38.2 Posterior mediastinum
0.427 0.573 0.000
C38.1 Anterior mediastinum
0.427 0.573 0.000
C38.0 Heart
0.427 0.573 0.000
I27.9 Pulmonary heart disease, unspecified
0.425 0.575 0.000
I95.1 Orthostatic hypotension
0.423 0.577 0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.422 0.578 0.000
I05.2 Mitral stenosis with insufficiency
0.421 0.579 0.000
J96.9 Respiratory failure, unspecified
0.421 0.579 0.000
J96.1 Chronic respiratory failure
0.421 0.579 0.000
J96.0 Acute respiratory failure
0.421 0.579 0.000
C30.1 Middle ear
0.419 0.581 0.000
I72 Other aneurysm
0.418 0.582 0.000
I66.8 Occlusion and stenosis of other cerebral artery
0.415 0.584 0.000
I66.2 Occlusion and stenosis of posterior cerebral artery
0.415 0.584 0.000
I66.1 Occlusion and stenosis of anterior cerebral artery
0.415 0.584 0.000
I97.2 Postmastectomy lymphoedema syndrome
0.413 0.586 0.000
J41.0 Simple chronic bronchitis
0.413 0.587 0.000
J99.8 Respiratory disorders in other diseases classified elsewhere
0.412 0.587 0.000
J85.1 Abscess of lung with pneumonia
0.411 0.589 0.000
I42 Cardiomyopathy
0.405 0.595 0.000
J99.1 Respiratory disorders in other diffuse connective tissue disorders
0.403 0.597 0.000
J85.3 Abscess of mediastinum
0.402 0.598 0.000
K76.9 Liver disease, unspecified
0.399 0.601 0.000
I46.9 Cardiac arrest, unspecified
0.399 0.601 0.000
J20-J22 Other acute lower respiratory infections
0.398 0.602 0.000
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.394 0.605 0.000
C30.0 Nasal cavity
0.393 0.607 0.000
I26.0 Pulmonary embolism with mention of acute cor pulmonale
0.391 0.608 0.000
J95 Postprocedural respiratory disorders, not elsewhere classified
0.389 0.611 0.000
C38.4 Pleura
0.387 0.612 0.000
J70.9 Respiratory conditions due to unspecified external agent
0.386 0.614 0.000
J70.8 Respiratory conditions due to other specified external agents
0.386 0.614 0.000
J70.3 Chronic drug-induced interstitial lung disorders
0.386 0.614 0.000
J70.2 Acute drug-induced interstitial lung disorders
0.386 0.614 0.000
I36 Nonrheumatic tricuspid valve disorders
0.383 0.617 0.000
I28.1 Aneurysm of pulmonary artery
0.383 0.617 0.000
I28.0 Arteriovenous fistula of pulmonary vessels
0.383 0.617 0.000
I95.0 Idiopathic hypotension
0.382 0.617 0.000
I42.1 Obstructive hypertrophic cardiomyopathy
0.380 0.620 0.000
I42.2 Other hypertrophic cardiomyopathy
0.380 0.620 0.000
I66.0 Occlusion and stenosis of middle cerebral artery
0.379 0.621 0.000
I97.9 Postprocedural disorder of circulatory system, unspecified
0.379 0.621 0.000
I97.0 Postcardiotomy syndrome
0.379 0.621 0.000
J70.4 Drug-induced interstitial lung disorder, unspecified
0.379 0.621 0.000
J85.2 Abscess of lung without pneumonia
0.377 0.622 0.000
K72.0 Acute and subacute hepatic failure
0.375 0.625 0.000
I00 Rheumatic fever without mention of heart involvement
0.374 0.625 0.000
I65.2 Occlusion and stenosis of carotid artery
0.374 0.626 0.000
K75.8 Other specified inflammatory liver diseases
0.372 0.628 0.000
C31.9 Accessory sinus, unspecified
0.370 0.630 0.000
C31.8 Overlapping lesion of accessory sinuses
0.370 0.630 0.000
C31.3 Sphenoidal sinus
0.370 0.630 0.000
C31.2 Frontal sinus
0.370 0.630 0.000
C31.1 Ethmoidal sinus
0.370 0.630 0.000
I66.3 Occlusion and stenosis of cerebellar arteries
0.368 0.632 0.000
I63.9 Cerebral infarction, unspecified
0.368 0.632 0.000
I05.8 Other mitral valve diseases
0.367 0.632 0.000
I28.8 Other specified diseases of pulmonary vessels
0.367 0.633 0.000
I05.1 Rheumatic mitral insufficiency
0.363 0.637 0.000
J70.0 Acute pulmonary manifestations due to radiation
0.358 0.642 0.000
I65.8 Occlusion and stenosis of other precerebral artery
0.354 0.645 0.000
I07.9 Tricuspid valve disease, unspecified
0.352 0.647 0.000
I07.8 Other tricuspid valve diseases
0.352 0.647 0.000
I07.2 Tricuspid stenosis with insufficiency
0.352 0.647 0.000
I07.0 Tricuspid stenosis
0.352 0.647 0.000
I42.6 Alcoholic cardiomyopathy
0.348 0.652 0.000
I46.1 Sudden cardiac death, so described
0.345 0.654 0.000
J70.1 Chronic and other pulmonary manifestations due to radiation
0.345 0.655 0.000
I66.9 Occlusion and stenosis of unspecified cerebral artery
0.344 0.656 0.000
I50 Heart failure
0.342 0.658 0.000
I33 Acute and subacute endocarditis
0.341 0.659 0.000
J85.0 Gangrene and necrosis of lung
0.341 0.659 0.000
J98.8 Other specified respiratory disorders
0.338 0.662 0.000
I65.9 Occlusion and stenosis of unspecified precerebral artery
0.338 0.662 0.000
I74.5 Embolism and thrombosis of iliac artery
0.338 0.662 0.000
I36.1 Nonrheumatic tricuspid (valve) insufficiency
0.338 0.662 0.000
I27.1 Kyphoscoliotic heart disease
0.326 0.674 0.000
I01.9 Acute rheumatic heart disease, unspecified
0.325 0.674 0.000
I01.8 Other acute rheumatic heart disease
0.325 0.674 0.000
I01.2 Acute rheumatic myocarditis
0.325 0.674 0.000
I01.1 Acute rheumatic endocarditis
0.325 0.674 0.000
I01.0 Acute rheumatic pericarditis
0.325 0.674 0.000
I02.9 Rheumatic chorea without heart involvement
0.325 0.674 0.000
I02.0 Rheumatic chorea with heart involvement
0.325 0.674 0.000
J67.8 Hypersensitivity pneumonitis due to other organic dusts
0.325 0.675 0.000
J67.7 Air-conditioner and humidifier lung
0.325 0.675 0.000
J67.6 Maple-bark-stripper's lung
0.325 0.675 0.000
J67.5 Mushroom-worker's lung
0.325 0.675 0.000
J67.4 Maltworker's lung
0.325 0.675 0.000
J67.3 Suberosis
0.325 0.675 0.000
J67.1 Bagassosis
0.325 0.675 0.000
J67.0 Farmer's lung
0.325 0.675 0.000
I62.1 Nontraumatic extradural haemorrhage
0.324 0.675 0.000
I42.7 Cardiomyopathy due to drugs and other external agents
0.324 0.675 0.000
K75.2 Nonspecific reactive hepatitis
0.321 0.679 0.000
K75.1 Phlebitis of portal vein
0.321 0.679 0.000
I52 Other heart disorders in diseases classified elsewhere
0.321 0.679 0.000
I48 Atrial fibrillation and flutter
0.321 0.679 0.000
I41 Myocarditis in diseases classified elsewhere
0.321 0.679 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.321 0.679 0.000
I32 Pericarditis in diseases classified elsewhere
0.321 0.679 0.000
K75.9 Inflammatory liver disease, unspecified
0.321 0.679 0.000
I72.1 Aneurysm of artery of upper extremity
0.319 0.681 0.000
J95.0 Tracheostomy malfunction
0.315 0.685 0.000
I27.8 Other specified pulmonary heart diseases
0.315 0.685 0.000
I34 Nonrheumatic mitral valve disorders
0.315 0.685 0.000
I97.1 Other functional disturbances following cardiac surgery
0.314 0.686 0.000
I38 Endocarditis, valve unspecified
0.311 0.689 0.000
I62.0 Subdural haemorrhage (acute) (nontraumatic)
0.310 0.690 0.000
K75.3 Granulomatous hepatitis, not elsewhere classified
0.310 0.690 0.000
I97.8 Other postprocedural disorders of circulatory system, not elsewhere classified
0.307 0.693 0.000
J94.2 Haemothorax
0.303 0.696 0.000
K74.3 Primary biliary cirrhosis
0.302 0.698 0.000
J96.09 Acute respiratory failure; Type unspecified
0.302 0.698 0.000
J96.01 Acute respiratory failure; Type II [hypercapnic]
0.302 0.698 0.000
J96.00 Acute respiratory failure; Type I [hypoxic]
0.302 0.698 0.000
J96.19 Chronic respiratory failure; Type unspecified
0.302 0.698 0.000
J96.11 Chronic respiratory failure; Type II [hypercapnic]
0.302 0.698 0.000
J96.10 Chronic respiratory failure; Type I [hypoxic]
0.302 0.698 0.000
J96.99 Respiratory failure, unspecified; Type unspecified
0.302 0.698 0.000
J96.91 Respiratory failure unspecified; Type II [hypercapnic]
0.302 0.698 0.000
J96.90 Respiratory failure, unspecified; Type I [hypoxic]
0.302 0.698 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.302 0.698 0.000
I72.6 Aneurysm and dissection of vertebral artery
0.300 0.700 0.000
I72.5 Aneurysm and dissection of other precerebral arteries
0.300 0.700 0.000
I50.0 Congestive heart failure
0.297 0.703 0.000
J20 Acute bronchitis
0.296 0.704 0.000
K74.0 Hepatic fibrosis
0.294 0.706 0.000
I72.9 Aneurysm of unspecified site
0.294 0.706 0.000
I72.4 Aneurysm of artery of lower extremity
0.293 0.707 0.000
I42.3 Endomyocardial (eosinophilic) disease
0.290 0.710 0.000
J95.5 Postprocedural subglottic stenosis
0.290 0.710 0.000
I07.1 Tricuspid insufficiency
0.290 0.710 0.000
I72.0 Aneurysm of carotid artery
0.287 0.713 0.000
J91 Pleural effusion in conditions classified elsewhere
0.285 0.715 0.000
I65.3 Occlusion and stenosis of multiple and bilateral precerebral arteries
0.284 0.715 0.000
J95.4 Mendelson's syndrome
0.279 0.721 0.000
J95.3 Chronic pulmonary insufficiency following surgery
0.279 0.721 0.000
J95.1 Acute pulmonary insufficiency following thoracic surgery
0.279 0.721 0.000
I34.1 Mitral (valve) prolapse
0.278 0.722 0.000
J00-J06 Acute upper respiratory infections
0.277 0.723 0.000
I42.5 Other restrictive cardiomyopathy
0.277 0.723 0.000
J67.2 Bird fancier's lung
0.277 0.723 0.001
C31.0 Maxillary sinus
0.276 0.723 0.001
I36.9 Nonrheumatic tricuspid valve disorder, unspecified
0.275 0.725 0.000
I36.8 Other nonrheumatic tricuspid valve disorders
0.275 0.725 0.000
I36.2 Nonrheumatic tricuspid (valve) stenosis with insufficiency
0.275 0.725 0.000
I36.0 Nonrheumatic tricuspid (valve) stenosis
0.275 0.725 0.000
I26.9 Pulmonary embolism without mention of acute cor pulmonale
0.274 0.726 0.000
I85 Oesophageal varices
0.274 0.726 0.000
I72.8 Aneurysm of other specified arteries
0.273 0.726 0.000
I37 Pulmonary valve disorders
0.273 0.726 0.000
I42.4 Endocardial fibroelastosis
0.272 0.727 0.000
J69.0 Pneumonitis due to food and vomit
0.272 0.728 0.000
I85.9 Oesophageal varices without bleeding
0.271 0.729 0.000
J21 Acute bronchiolitis
0.271 0.729 0.000
I34.8 Other nonrheumatic mitral valve disorders
0.266 0.734 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.265 0.735 0.000
I40 Acute myocarditis
0.264 0.736 0.000
J40 Bronchitis, not specified as acute or chronic
0.264 0.736 0.000
I33.0 Acute and subacute infective endocarditis
0.263 0.737 0.000
I63.3 Cerebral infarction due to thrombosis of cerebral arteries
0.262 0.738 0.000
J95.2 Acute pulmonary insufficiency following nonthoracic surgery
0.261 0.739 0.000
I85.0 Oesophageal varices with bleeding
0.261 0.739 0.000
I34.2 Nonrheumatic mitral (valve) stenosis
0.255 0.745 0.000
I67.8 Other specified cerebrovascular diseases
0.253 0.747 0.000
I33.9 Acute endocarditis, unspecified
0.248 0.752 0.000
I50.1 Left ventricular failure
0.243 0.757 0.000
I05.9 Mitral valve disease, unspecified
0.243 0.757 0.000
K76.8 Other specified diseases of liver
0.241 0.759 0.000
I72.2 Aneurysm of renal artery
0.240 0.759 0.000
I63.8 Other cerebral infarction
0.240 0.760 0.000
I65.0 Occlusion and stenosis of vertebral artery
0.237 0.762 0.001
J67.9 Hypersensitivity pneumonitis due to unspecified organic dust
0.234 0.765 0.001
I61 Intracerebral haemorrhage
0.235 0.765 0.000
J45 Asthma
0.233 0.767 0.000
I65.1 Occlusion and stenosis of basilar artery
0.232 0.767 0.001
I32.8 Pericarditis in other diseases classified elsewhere
0.230 0.770 0.000
I32.1 Pericarditis in other infectious and parasitic diseases classified elsewhere
0.230 0.770 0.000
I32.0 Pericarditis in bacterial diseases classified elsewhere
0.230 0.770 0.000
I39.8 Endocarditis, valve unspecified, in diseases classified elsewhere
0.230 0.770 0.000
I39.4 Multiple valve disorders in diseases classified elsewhere
0.230 0.770 0.000
I39.3 Pulmonary valve disorders in diseases classified elsewhere
0.230 0.770 0.000
I39.2 Tricuspid valve disorders in diseases classified elsewhere
0.230 0.770 0.000
I39.1 Aortic valve disorders in diseases classified elsewhere
0.230 0.770 0.000
I39.0 Mitral valve disorders in diseases classified elsewhere
0.230 0.770 0.000
I41.8 Myocarditis in other diseases classified elsewhere
0.230 0.770 0.000
I41.2 Myocarditis in other infectious and parasitic diseases classified elsewhere
0.230 0.770 0.000
I41.1 Myocarditis in viral diseases classified elsewhere
0.230 0.770 0.000
I41.0 Myocarditis in bacterial diseases classified elsewhere
0.230 0.770 0.000
I48.9 Atrial fibrillation and atrial flutter, unspecified
0.230 0.770 0.000
I48.4 Atypical atrial flutter
0.230 0.770 0.000
I48.3 Typical atrial flutter
0.230 0.770 0.000
I48.2 Chronic atrial fibrillation
0.230 0.770 0.000
I48.1 Persistent atrial fibrillation
0.230 0.770 0.000
I48.0 Paroxysmal atrial fibrillation
0.230 0.770 0.000
I52.8 Other heart disorders in other diseases classified elsewhere
0.230 0.770 0.000
I52.1 Other heart disorders in other infectious and parasitic diseases classified elsewhere
0.230 0.770 0.000
I52.0 Other heart disorders in bacterial diseases classified elsewhere
0.230 0.770 0.000
J20.9 Acute bronchitis, unspecified
0.229 0.771 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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