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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs853678
log Bayes Factor = 135.476
Chromosome 6   position 28,297,313  (GRCh37) Explore rs853678 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E05.9 Thyrotoxicosis, unspecified
1.000 0.000 0.000
E10.9 Without complications
1.000 0.000 0.000
K90.0 Coeliac disease
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
1.000 0.000 0.000
R31 Unspecified haematuria
0.000 0.000 1.000
E10-E14 Diabetes mellitus
1.000 0.000 0.000
E00-E07 Disorders of thyroid gland
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
E05 Thyrotoxicosis [hyperthyroidism]
1.000 0.000 0.000
K70-K77 Diseases of liver
1.000 0.000 0.000
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
N40 Hyperplasia of prostate
0.000 0.000 1.000
Chapter XI Diseases of the digestive system
1.000 0.000 0.000
K75 Other inflammatory liver diseases
1.000 0.000 0.000
E03 Other hypothyroidism
1.000 0.000 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
1.000 0.000 0.000
E83.1 Disorders of iron metabolism
0.000 0.000 1.000
K90 Intestinal malabsorption
1.000 0.000 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
1.000 0.000 0.000
K75.4 Autoimmune hepatitis
1.000 0.000 0.000
E16 Other disorders of pancreatic internal secretion
1.000 0.000 0.000
E16.2 Hypoglycaemia, unspecified
0.999 0.001 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.999 0.001 0.000
Chapter VII Diseases of the eye and adnexa
0.999 0.001 0.000
K90-K93 Other diseases of the digestive system
0.999 0.001 0.000
E11 Non-insulin-dependent diabetes mellitus
0.998 0.002 0.000
E20-E35 Disorders of other endocrine glands
0.997 0.003 0.000
E27 Other disorders of adrenal gland
0.997 0.003 0.000
E11.9 Without complications
0.996 0.004 0.000
E10.3 With ophthalmic complications
0.995 0.005 0.000
E27.1 Primary adrenocortical insufficiency
0.995 0.005 0.000
D64.9 Anaemia, unspecified
0.994 0.006 0.000
D60-D64 Aplastic and other anaemias
0.994 0.006 0.000
D64 Other anaemias
0.993 0.007 0.000
M20-M25 Other joint disorders
0.990 0.010 0.000
K72 Hepatic failure, not elsewhere classified
0.988 0.012 0.000
M05-M14 Inflammatory polyarthropathies
0.986 0.014 0.000
D80-D89 Certain disorders involving the immune mechanism
0.984 0.016 0.000
D50-D53 Nutritional anaemias
0.984 0.016 0.000
M35 Other systemic involvement of connective tissue
0.981 0.019 0.000
D50 Iron deficiency anaemia
0.979 0.021 0.000
E10.1 With ketoacidosis
0.978 0.022 0.000
M35.0 Sicca syndrome [Sjogren]
0.978 0.022 0.000
E14 Unspecified diabetes mellitus
0.974 0.026 0.000
E05.0 Thyrotoxicosis with diffuse goitre
0.973 0.027 0.000
D50.8 Other iron deficiency anaemias
0.970 0.030 0.000
H25-H28 Disorders of lens
0.968 0.032 0.000
E11.5 With peripheral circulatory complications
0.962 0.038 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.958 0.042 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.953 0.047 0.000
K75.9 Inflammatory liver disease, unspecified
0.951 0.049 0.000
D86 Sarcoidosis
0.950 0.050 0.000
M65-M68 Disorders of synovium and tendon
0.949 0.051 0.000
K35-K38 Diseases of appendix
0.946 0.054 0.000
H02 Other disorders of eyelid
0.945 0.055 0.000
K72.9 Hepatic failure, unspecified
0.945 0.055 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.943 0.057 0.000
K73 Chronic hepatitis, not elsewhere classified
0.939 0.061 0.000
K35 Acute appendicitis
0.938 0.062 0.000
K35.9 Acute appendicitis, unspecified
0.937 0.063 0.000
M07 Psoriatic and enteropathic arthropathies
0.936 0.064 0.000
H26 Other cataract
0.934 0.066 0.000
M15-M19 Arthrosis
0.934 0.066 0.000
N40-N51 Diseases of male genital organs
0.000 0.068 0.932
M67 Other disorders of synovium and tendon
0.931 0.069 0.000
H26.9 Cataract, unspecified
0.931 0.069 0.000
N42 Other disorders of prostate
0.000 0.070 0.930
K72.0 Acute and subacute hepatic failure
0.929 0.071 0.000
M60-M63 Disorders of muscles
0.927 0.073 0.000
M17 Gonarthrosis [arthrosis of knee]
0.919 0.081 0.000
M67.8 Other specified disorders of synovium and tendon
0.919 0.081 0.000
M11 Other crystal arthropathies
0.918 0.082 0.000
H02.5 Other disorders affecting eyelid function
0.917 0.083 0.000
K90.9 Intestinal malabsorption, unspecified
0.917 0.083 0.000
H02.1 Ectropion of eyelid
0.916 0.084 0.000
H02.6 Xanthelasma of eyelid
0.914 0.086 0.000
H27 Other disorders of lens
0.913 0.087 0.000
E10.2 With renal complications
0.911 0.089 0.000
H43-H45 Disorders of vitreous body and globe
0.911 0.089 0.000
E14.9 Without complications
0.911 0.089 0.000
M17.9 Gonarthrosis, unspecified
0.909 0.091 0.000
H53-H54 Visual disturbances and blindness
0.909 0.091 0.000
K75.8 Other specified inflammatory liver diseases
0.906 0.094 0.000
D50.9 Iron deficiency anaemia, unspecified
0.901 0.099 0.000
M07.3 Other psoriatic arthropathies
0.901 0.099 0.000
M10 Gout
0.899 0.101 0.000
M34 Systemic sclerosis
0.897 0.103 0.000
N42.8 Other specified disorders of prostate
0.000 0.106 0.894
D86.9 Sarcoidosis, unspecified
0.885 0.115 0.000
H46 Optic neuritis
0.883 0.117 0.000
M62 Other disorders of muscle
0.883 0.117 0.000
N42.9 Disorder of prostate, unspecified
0.000 0.125 0.875
M23 Internal derangement of knee
0.873 0.127 0.000
E14.3 With ophthalmic complications
0.872 0.128 0.000
K73.2 Chronic active hepatitis, not elsewhere classified
0.870 0.130 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.866 0.134 0.000
M11.2 Other chondrocalcinosis
0.864 0.136 0.000
M07.39 Other psoriatic arthropathies (Site unspecified)
0.862 0.138 0.000
H54 Blindness and low vision
0.853 0.147 0.000
H05 Disorders of orbit
0.845 0.155 0.000
H27.0 Aphakia
0.839 0.161 0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.836 0.164 0.000
E11.3 With ophthalmic complications
0.834 0.166 0.000
K35.1 Acute appendicitis with peritoneal abscess
0.833 0.167 0.000
D83 Common variable immunodeficiency
0.826 0.174 0.000
E10.4 With neurological complications
0.825 0.175 0.000
E10.7 With multiple complications
0.823 0.177 0.000
M31 Other necrotising vasculopathies
0.822 0.178 0.000
H30-H36 Disorders of choroid and retina
0.821 0.179 0.000
M10.0 Idiopathic gout
0.818 0.182 0.000
E27.2 Addisonian crisis
0.817 0.183 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.815 0.185 0.000
N42.1 Congestion and haemorrhage of prostate
0.000 0.186 0.814
E31 Polyglandular dysfunction
0.809 0.191 0.000
M11.26 Other chondrocalcinosis (Lower leg)
0.808 0.192 0.000
K40.9 Unilateral or unspecified inguinal hernia, without obstruction or gangrene
0.000 0.195 0.805
E20 Hypoparathyroidism
0.802 0.198 0.000
H43 Disorders of vitreous body
0.802 0.198 0.000
E23 Hypofunction and other disorders of pituitary gland
0.800 0.200 0.000
K40 Inguinal hernia
0.001 0.203 0.796
E10.0 With coma
0.793 0.207 0.000
M91-M94 Chondropathies
0.792 0.208 0.000
K44.9 Diaphragmatic hernia without obstruction or gangrene
0.000 0.208 0.792
E14.1 With ketoacidosis
0.790 0.210 0.000
M35.1 Other overlap syndromes
0.789 0.210 0.000
K40-K46 Hernia
0.012 0.211 0.777
E07 Other disorders of thyroid
0.787 0.213 0.000
K44 Diaphragmatic hernia
0.006 0.214 0.780
D80 Immunodeficiency with predominantly antibody defects
0.781 0.219 0.000
D86.0 Sarcoidosis of lung
0.778 0.222 0.000
M33 Dermatopolymyositis
0.778 0.222 0.000
E27.3 Drug-induced adrenocortical insufficiency
0.776 0.224 0.000
M62.8 Other specified disorders of muscle
0.775 0.225 0.000
H36 Retinal disorders in diseases classified elsewhere
0.775 0.225 0.000
D55-D59 Haemolytic anaemias
0.770 0.230 0.000
E10.6 With other specified complications
0.769 0.231 0.000
M34.1 CR(E)ST syndrome
0.768 0.232 0.000
H43.1 Vitreous haemorrhage
0.767 0.233 0.000
H47 Other disorders of optic [2nd] nerve and visual pathways
0.767 0.233 0.000
M22 Disorders of patella
0.767 0.233 0.000
H26.1 Traumatic cataract
0.767 0.233 0.000
D84 Other immunodeficiencies
0.766 0.234 0.000
H03 Disorders of eyelid in diseases classified elsewhere
0.762 0.238 0.000
H44 Disorders of globe
0.760 0.240 0.000
E10.5 With peripheral circulatory complications
0.760 0.240 0.000
E11.6 With other specified complications
0.758 0.242 0.000
M23.9 Internal derangement of knee, unspecified
0.758 0.242 0.000
H16 Keratitis
0.756 0.244 0.000
M07.36 Other psoriatic arthropathies (Lower leg)
0.753 0.247 0.000
N42.0 Calculus of prostate
0.000 0.248 0.752
H27.1 Dislocation of lens
0.752 0.248 0.000
E24 Cushing's syndrome
0.750 0.250 0.000
E50-E64 Other nutritional deficiencies
0.750 0.250 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.749 0.251 0.000
D86.1 Sarcoidosis of lymph nodes
0.746 0.254 0.000
M32 Systemic lupus erythematosus
0.745 0.255 0.000
H05.0 Acute inflammation of orbit
0.745 0.255 0.000
M62.6 Muscle strain
0.744 0.255 0.000
H36.0 Diabetic retinopathy
0.741 0.259 0.000
M10.07 Idiopathic gout (Ankle and foot)
0.740 0.260 0.000
K73.9 Chronic hepatitis, unspecified
0.739 0.261 0.000
M13 Other arthritis
0.738 0.262 0.000
E14.2 Withrenal complications
0.737 0.263 0.000
H34 Retinal vascular occlusions
0.736 0.264 0.000
K74 Fibrosis and cirrhosis of liver
0.735 0.265 0.000
E25 Adrenogenital disorders
0.730 0.270 0.000
N41 Inflammatory diseases of prostate
0.000 0.271 0.729
D86.3 Sarcoidosis of skin
0.729 0.271 0.000
M15 Polyarthrosis
0.728 0.272 0.000
M12 Other specific arthropathies
0.728 0.272 0.000
E14.5 With peripheral circulatory complications
0.726 0.274 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.725 0.275 0.000
E06 Thyroiditis
0.725 0.275 0.000
M23.3 Other meniscus derangements
0.723 0.277 0.000
D53 Other nutritional anaemias
0.722 0.277 0.000
K73.8 Other chronic hepatitis, not elsewhere classified
0.718 0.281 0.000
M31.6 Other giant cell arteritis
0.718 0.282 0.000
M17.1 Other primary gonarthrosis
0.717 0.283 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.717 0.283 0.000
E00 Congenital iodine-deficiency syndrome
0.717 0.283 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.717 0.283 0.000
E12 Malnutrition-related diabetes mellitus
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
E05.5 Thyroid crisis or storm
0.717 0.283 0.000
E05.4 Thyrotoxicosis factitia
0.717 0.283 0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.717 0.283 0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.717 0.283 0.000
K77 Liver disorders in diseases classified elsewhere
0.717 0.283 0.000
K71 Toxic liver disease
0.717 0.283 0.000
E03.5 Myxoedema coma
0.717 0.283 0.000
E03.4 Atrophy of thyroid (acquired)
0.717 0.283 0.000
E03.3 Postinfectious hypothyroidism
0.717 0.283 0.000
E03.1 Congenital hypothyroidism without goitre
0.717 0.283 0.000
E03.0 Congenital hypothyroidism with diffuse goitre
0.717 0.283 0.000
K75.3 Granulomatous hepatitis, not elsewhere classified
0.717 0.283 0.000
K75.2 Nonspecific reactive hepatitis
0.717 0.283 0.000
K75.1 Phlebitis of portal vein
0.717 0.283 0.000
K90.3 Pancreatic steatorrhoea
0.717 0.283 0.000
K90.2 Blind loop syndrome, not elsewhere classified
0.717 0.283 0.000
K90.1 Tropical sprue
0.717 0.283 0.000
E15 Nondiabetic hypoglycaemic coma
0.717 0.283 0.000
E16.9 Disorder of pancreatic internal secretion, unspecified
0.717 0.283 0.000
E16.8 Other specified disorders of pancreatic internal secretion
0.717 0.283 0.000
E16.4 Abnormal secretion of gastrin
0.717 0.283 0.000
E16.3 Increased secretion of glucagon
0.717 0.283 0.000
K93 Disorders of other digestive organs in diseases classified elsewhere
0.716 0.284 0.000
M34.8 Other forms of systemic sclerosis
0.716 0.284 0.000
E11.7 With multiple complications
0.716 0.284 0.000
E16.1 Other hypoglycaemia
0.715 0.285 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.715 0.285 0.000
E32 Diseases of thymus
0.715 0.285 0.000
E30 Disorders of puberty, not elsewhere classified
0.715 0.285 0.000
M67.0 Short Achilles tendon (acquired)
0.715 0.285 0.000
E27.5 Adrenomedullary hyperfunction
0.715 0.285 0.000
E27.0 Other adrenocortical overactivity
0.715 0.285 0.000
D83.9 Common variable immunodeficiency, unspecified
0.713 0.287 0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.712 0.287 0.000
D64.4 Congenital dyserythropoietic anaemia
0.712 0.288 0.000
D64.3 Other sideroblastic anaemias
0.712 0.288 0.000
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.712 0.288 0.000
D64.1 Secondary sideroblastic anaemia due to disease
0.712 0.288 0.000
D64.0 Hereditary sideroblastic anaemia
0.712 0.288 0.000
E10.8 With unspecified complications
0.712 0.288 0.000
M34.9 Systemic sclerosis, unspecified
0.712 0.288 0.000
E11.0 With coma
0.711 0.289 0.000
H19 Disorders of sclera and cornea in diseases classified elsewhere
0.710 0.290 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.710 0.290 0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.709 0.290 0.000
H54.7 Unspecified visual loss
0.709 0.291 0.000
K72.1 Chronic hepatic failure
0.708 0.292 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.707 0.293 0.000
M08 Juvenile arthritis
0.707 0.293 0.000
M67.4 Ganglion
0.706 0.294 0.000
M14 Arthropathies in other diseases classified elsewhere
0.706 0.294 0.000
N44 Torsion of testis
0.000 0.294 0.706
D82 Immunodeficiency associated with other major defects
0.706 0.294 0.000
D81 Combined immunodeficiencies
0.706 0.294 0.000
M23.5 Chronic instability of knee
0.704 0.296 0.000
M35.9 Systemic involvement of connective tissue, unspecified
0.703 0.297 0.000
M35.8 Other specified systemic involvement of connective tissue
0.703 0.297 0.000
M35.6 Relapsing panniculitis [Weber-Christian]
0.703 0.297 0.000
M35.5 Multifocal fibrosclerosis
0.703 0.297 0.000
M35.4 Diffuse (eosinophilic) fasciitis
0.703 0.297 0.000
M62.5 Muscle wasting and atrophy, not elsewhere classified
0.703 0.297 0.000
M10.9 Gout, unspecified
0.703 0.297 0.000
N49 Inflammatory disorders of male genital organs, not elsewhere classified
0.000 0.297 0.703
H54.4 Blindness, one eye
0.703 0.297 0.000
K40.2 Bilateral inguinal hernia, without obstruction or gangrene
0.000 0.297 0.703
D50.1 Sideropenic dysphagia
0.702 0.298 0.000
K90.8 Other intestinal malabsorption
0.699 0.301 0.000
E14.7 With multiple complications
0.699 0.301 0.000
E14.0 With coma
0.699 0.301 0.000
K35.2 Acute appendicitis with generalized peritonitis
0.698 0.301 0.000
H54.9 Unspecified visual impairment (binocular)
0.696 0.304 0.000
M62.0 Diastasis of muscle
0.696 0.304 0.000
N45 Orchitis and epididymitis
0.000 0.305 0.695
M11.27 Other chondrocalcinosis (Ankle and foot)
0.694 0.306 0.000
M20.1 Hallux valgus (acquired)
0.000 0.306 0.694
H28 Cataract and other disorders of lens in diseases classified elsewhere
0.694 0.306 0.000
H27.8 Other specified disorders of lens
0.694 0.306 0.000
M20 Acquired deformities of fingers and toes
0.003 0.308 0.689
D86.8 Sarcoidosis of other and combined sites
0.692 0.308 0.000
M13.0 Polyarthritis, unspecified
0.691 0.309 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.691 0.309 0.000
N43 Hydrocele and spermatocele
0.000 0.310 0.690
M20.5 Other deformities of toe(s) (acquired)
0.000 0.311 0.689
H21 Other disorders of iris and ciliary body
0.688 0.312 0.000
H02.3 Blepharochalasis
0.688 0.312 0.000
E03.8 Other specified hypothyroidism
0.687 0.313 0.000
M67.2 Synovial hypertrophy, not elsewhere classified
0.687 0.313 0.000
H47.2 Optic atrophy
0.687 0.313 0.000
M23.4 Loose body in knee
0.685 0.314 0.000
M11.9 Crystal arthropathy, unspecified
0.685 0.315 0.000
E27.9 Disorder of adrenal gland, unspecified
0.685 0.315 0.000
N42.2 Atrophy of prostate
0.000 0.316 0.684
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.681 0.319 0.000
E05.8 Other thyrotoxicosis
0.681 0.319 0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.681 0.319 0.000
E13 Other specified diabetes mellitus
0.680 0.320 0.000
E23.2 Diabetes insipidus
0.679 0.321 0.000
M23.6 Other spontaneous disruption of ligament(s) of knee
0.679 0.321 0.000
H02.2 Lagophthalmos
0.678 0.322 0.000
H02.7 Other degenerative disorders of eyelid and periocular area
0.677 0.322 0.000
E14.6 With other specified complications
0.677 0.323 0.000
H48 Disorders of optic [2nd] nerve and visual pathways in diseases classified elsewhere
0.676 0.324 0.000
M23.0 Cystic meniscus
0.676 0.324 0.000
E31.0 Autoimmune polyglandular failure
0.674 0.325 0.000
K73.1 Chronic lobular hepatitis, not elsewhere classified
0.673 0.327 0.000
K73.0 Chronic persistent hepatitis, not elsewhere classified
0.673 0.327 0.000
M62.86 Other specified disorders of muscle (Lower leg)
0.673 0.327 0.000
H54.6 Unqualified visual loss, one eye
0.672 0.328 0.000
H01 Other inflammation of eyelid
0.672 0.328 0.000
M07.6 Other enteropathic arthropathies
0.671 0.329 0.000
M07.5 Arthropathy in ulcerative colitis
0.671 0.329 0.000
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.671 0.329 0.000
M07.2 Psoriatic spondylitis
0.671 0.329 0.000
M07.1 Arthritis mutilans
0.671 0.329 0.000
M07.0 Distal interphalangeal psoriatic arthropathy
0.671 0.329 0.000
L20-L30 Dermatitis and eczema
0.671 0.329 0.000
H26.3 Drug-induced cataract
0.670 0.330 0.000
M19 Other arthrosis
0.670 0.330 0.000
M17.3 Other posttraumatic gonarthrosis
0.670 0.330 0.000
M66 Spontaneous rupture of synovium and tendon
0.669 0.331 0.000
N51 Disorders of male genital organs in diseases classified elsewhere
0.000 0.332 0.668
M22.3 Other derangements of patella
0.668 0.332 0.000
M67.9 Disorder of synovium and tendon, unspecified
0.668 0.332 0.000
M67.3 Transient synovitis
0.668 0.332 0.000
M13.00 Polyarthritis, unspecified (Multiple sites)
0.667 0.333 0.000
N42.3 Dysplasia of prostate
0.000 0.333 0.667
H15 Disorders of sclera
0.666 0.334 0.000
M63 Disorders of muscle in diseases classified elsewhere
0.665 0.335 0.000
M61 Calcification and ossification of muscle
0.665 0.335 0.000
Q50-Q56 Congenital malformations of genital organs
0.664 0.336 0.000
E20.9 Hypoparathyroidism, unspecified
0.663 0.337 0.000
M23.99 Internal derangement of knee, unspecified (Unspecified ligament or Unspecified meniscus)
0.660 0.340 0.000
M62.83 Other specified disorders of muscle (Forearm)
0.659 0.341 0.000
M17.4 Other secondary gonarthrosis, bilateral
0.659 0.341 0.000
M17.2 Posttraumatic gonarthrosis, bilateral
0.659 0.341 0.000
M00-M03 Infectious arthropathies
0.658 0.342 0.000
M11.8 Other specified crystal arthropathies
0.658 0.342 0.000
M11.1 Familial chondrocalcinosis
0.658 0.342 0.000
M11.0 Hydroxyapatite deposition disease
0.658 0.342 0.000
Chapter IX Diseases of the circulatory system
0.657 0.343 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.657 0.343 0.000
H27.9 Disorder of lens, unspecified
0.655 0.345 0.000
M35.7 Hypermobility syndrome
0.654 0.346 0.000
E14.4 With neurological complications
0.653 0.347 0.000
H45 Disorders of vitreous body and globe in diseases classified elsewhere
0.653 0.347 0.000
D61 Other aplastic anaemias
0.648 0.351 0.000
E14.8 With unspecified complications
0.648 0.352 0.000
E29 Testicular dysfunction
0.647 0.353 0.000
H05.8 Other disorders of orbit
0.647 0.353 0.000
M17.0 Primary gonarthrosis, bilateral
0.646 0.354 0.000
M10.06 Idiopathic gout (Lower leg)
0.646 0.354 0.000
M07.38 Other psoriatic arthropathies (Other)
0.646 0.354 0.000
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.646 0.354 0.000
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.646 0.354 0.000
M07.34 Other psoriatic arthropathies (Hand)
0.646 0.354 0.000
M07.33 Other psoriatic arthropathies (Forearm)
0.646 0.354 0.000
M07.32 Other psoriatic arthropathies (Upper arm)
0.646 0.354 0.000
M07.31 Other psoriatic arthropathies (Shoulder region)
0.646 0.354 0.000
H02.0 Entropion and trichiasis of eyelid
0.646 0.354 0.000
M10.4 Other secondary gout
0.644 0.356 0.000
M10.3 Gout due to impairment of renal function
0.644 0.356 0.000
M10.2 Drug-induced gout
0.644 0.356 0.000
M10.1 Lead-induced gout
0.644 0.356 0.000
H22 Disorders of iris and ciliary body in diseases classified elsewhere
0.643 0.357 0.000
H34.8 Other retinal vascular occlusions
0.643 0.357 0.000
M34.2 Systemic sclerosis induced by drugs and chemicals
0.643 0.357 0.000
M34.0 Progressive systemic sclerosis
0.643 0.357 0.000
M31.0 Hypersensitivity angiitis
0.641 0.359 0.000
M23.36 Other meniscus derangements (Other and unspecified lateral meniscus)
0.640 0.360 0.000
M93 Other osteochondropathies
0.640 0.360 0.000
M23.35 Other meniscus derangements (Posterior horn of lateral meniscus)
0.639 0.361 0.000
M30 Polyarteritis nodosa and related conditions
0.637 0.363 0.000
M94 Other disorders of cartilage
0.636 0.364 0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.634 0.366 0.000
M62.9 Disorder of muscle, unspecified
0.633 0.367 0.000
M62.4 Contracture of muscle
0.633 0.367 0.000
M62.3 Immobility syndrome (paraplegic)
0.633 0.367 0.000
M62.2 Ischaemic infarction of muscle
0.633 0.367 0.000
M62.1 Other rupture of muscle (nontraumatic)
0.633 0.367 0.000
K40.0 Bilateral inguinal hernia, with obstruction, without gangrene
0.001 0.370 0.630
E24.2 Drug-induced Cushing's syndrome
0.630 0.370 0.000
L30 Other dermatitis
0.630 0.370 0.000
M62.65 Muscle strain (Pelvic region and thigh)
0.629 0.371 0.000
M62.81 Other specified disorders of muscle (Shoulder region)
0.629 0.371 0.000
M19.0 Primary arthrosis of other joints
0.628 0.372 0.000
N46 Male infertility
0.000 0.372 0.628
E40-E46 Malnutrition
0.627 0.373 0.000
M31.9 Necrotising vasculopathy, unspecified
0.626 0.373 0.000
H54.2 Low vision, both eyes
0.626 0.374 0.000
E07.8 Other specified disorders of thyroid
0.626 0.374 0.000
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.624 0.376 0.000
M60 Myositis
0.623 0.377 0.000
H44.0 Purulent endophthalmitis
0.622 0.378 0.000
M20.4 Other hammer toe(s) (acquired)
0.000 0.379 0.621
H16.8 Other keratitis
0.621 0.379 0.000
K41 Femoral hernia
0.004 0.379 0.617
H03.1 Involvement of eyelid in other infectious diseases classified elsewhere
0.621 0.379 0.000
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.620 0.380 0.000
M11.29 Other chondrocalcinosis (Site unspecified)
0.619 0.380 0.000
M11.28 Other chondrocalcinosis (Other)
0.619 0.380 0.000
M11.25 Other chondrocalcinosis (Pelvic region and thigh)
0.619 0.380 0.000
M11.24 Other chondrocalcinosis (Hand)
0.619 0.380 0.000
M11.23 Other chondrocalcinosis (Forearm)
0.619 0.380 0.000
M11.22 Other chondrocalcinosis (Upper arm)
0.619 0.380 0.000
M11.21 Other chondrocalcinosis (Shoulder region)
0.619 0.380 0.000
M11.20 Other chondrocalcinosis (Multiple sites)
0.619 0.380 0.000
M33.2 Polymyositis
0.619 0.381 0.000
H54.0 Blindness, both eyes
0.619 0.381 0.000
M18 Arthrosis of first carpometacarpal joint
0.619 0.381 0.000
M35.2 Behcet's disease
0.618 0.381 0.000
M07.30 Other psoriatic arthropathies (Multiple sites)
0.618 0.382 0.000
M23.30 Other meniscus derangements (Multiple sites)
0.618 0.382 0.000
D59 Acquired haemolytic anaemia
0.617 0.383 0.000
I78 Diseases of capillaries
0.616 0.384 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.614 0.386 0.000
M31.5 Giant cell arteritis with polymyalgia rheumatica
0.613 0.387 0.000
N41.1 Chronic prostatitis
0.000 0.387 0.613
H54.5 Low vision, one eye
0.612 0.388 0.000
H54.3 Unqualified visual loss, both eyes
0.612 0.388 0.000
H54.1 Blindness, one eye, low vision, other eye
0.612 0.388 0.000
M23.1 Discoid meniscus (congenital)
0.612 0.388 0.000
H20 Iridocyclitis
0.611 0.388 0.000
H53 Visual disturbances
0.611 0.389 0.000
H16.3 Interstitial and deep keratitis
0.611 0.389 0.000
H05.2 Exophthalmic conditions
0.611 0.389 0.000
M10.90 Gout, unspecified (Multiple sites)
0.610 0.390 0.000
D84.9 Immunodeficiency, unspecified
0.609 0.391 0.000
H34.2 Other retinal artery occlusions
0.608 0.392 0.000
H30 Chorioretinal inflammation
0.608 0.392 0.000
I60-I69 Cerebrovascular diseases
0.607 0.393 0.000
L28 Lichen simplex chronicus and prurigo
0.607 0.393 0.000
K74.6 Other and unspecified cirrhosis of liver
0.606 0.394 0.000
H05.9 Disorder of orbit, unspecified
0.606 0.394 0.000
H05.5 Retained (old) foreign body following penetrating wound of orbit
0.606 0.394 0.000
H05.4 Enophthalmos
0.606 0.394 0.000
H05.3 Deformity of orbit
0.606 0.394 0.000
H05.1 Chronic inflammatory disorders of orbit
0.606 0.394 0.000
E11.8 With unspecified complications
0.603 0.396 0.000
L30.9 Dermatitis, unspecified
0.603 0.397 0.000
L27 Dermatitis due to substances taken internally
0.603 0.397 0.000
D64.8 Other specified anaemias
0.601 0.399 0.000
L50-L54 Urticaria and erythema
0.600 0.400 0.000
K36 Other appendicitis
0.599 0.401 0.000
E61 Deficiency of other nutrient elements
0.599 0.401 0.000
M62.82 Other specified disorders of muscle (Upper arm)
0.598 0.401 0.000
N41.0 Acute prostatitis
0.000 0.403 0.597
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.597 0.403 0.000
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.596 0.404 0.000
K74.0 Hepatic fibrosis
0.596 0.404 0.000
I63 Cerebral infarction
0.595 0.405 0.000
I74 Arterial embolism and thrombosis
0.594 0.406 0.000
H44.2 Degenerative myopia
0.593 0.407 0.000
M24 Other specific joint derangements
0.593 0.407 0.000
D83.8 Other common variable immunodeficiencies
0.592 0.407 0.000
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.592 0.407 0.000
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.592 0.407 0.000
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.592 0.407 0.000
D52 Folate deficiency anaemia
0.592 0.408 0.000
E24.0 Pituitary-dependent Cushing's disease
0.590 0.410 0.000
H31 Other disorders of choroid
0.590 0.410 0.000
M10.94 Gout, unspecified (Hand)
0.590 0.410 0.000
M31.8 Other specified necrotising vasculopathies
0.590 0.410 0.000
M31.7 Microscopic polyangiitis
0.590 0.410 0.000
M31.4 Aortic arch syndrome [Takayasu]
0.590 0.410 0.000
M31.2 Lethal midline granuloma
0.590 0.410 0.000
M31.1 Thrombotic microangiopathy
0.590 0.410 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.589 0.411 0.000
I63.3 Cerebral infarction due to thrombosis of cerebral arteries
0.588 0.412 0.000
H43.9 Disorder of vitreous body, unspecified
0.587 0.413 0.000
M10.09 Idiopathic gout (Site unspecified)
0.586 0.414 0.000
M10.08 Idiopathic gout (Other)
0.586 0.414 0.000
M10.05 Idiopathic gout (Pelvic region and thigh)
0.586 0.414 0.000
M10.04 Idiopathic gout (Hand)
0.586 0.414 0.000
M10.03 Idiopathic gout (Forearm)
0.586 0.414 0.000
M10.02 Idiopathic gout (Upper arm)
0.586 0.414 0.000
M10.01 Idiopathic gout (Shoulder region)
0.586 0.414 0.000
M10.00 Idiopathic gout (Multiple sites)
0.586 0.414 0.000
D89.9 Disorder involving the immune mechanism, unspecified
0.585 0.414 0.000
I78.1 Naevus, nonneoplastic
0.585 0.415 0.000
M15.8 Other polyarthrosis
0.583 0.417 0.000
E34 Other endocrine disorders
0.582 0.417 0.000
M23.51 Chronic instability of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.581 0.419 0.000
E31.9 Polyglandular dysfunction, unspecified
0.580 0.420 0.000
E31.8 Other polyglandular dysfunction
0.580 0.420 0.000
E31.1 Polyglandular hyperfunction
0.580 0.420 0.000
M23.33 Other meniscus derangements (Medial collateral ligament or Other and unspecified medial meniscus)
0.580 0.420 0.000
E11.2 With renal complications
0.579 0.421 0.000
E28 Ovarian dysfunction
0.579 0.421 0.000
H53.1 Subjective visual disturbances
0.579 0.421 0.000
M17.5 Other secondary gonarthrosis
0.577 0.423 0.000
M23.93 Internal derangement of knee, unspecified (Medial collateral ligament or Other and unspecified medial meniscus)
0.577 0.423 0.000
H16.9 Keratitis, unspecified
0.577 0.423 0.000
E23.7 Disorder of pituitary gland, unspecified
0.576 0.423 0.000
E07.9 Disorder of thyroid, unspecified
0.576 0.424 0.000
E20.8 Other hypoparathyroidism
0.575 0.425 0.000
E20.1 Pseudohypoparathyroidism
0.575 0.425 0.000
E20.0 Idiopathic hypoparathyroidism
0.575 0.425 0.000
M19.01 Primary arthrosis of other joints (Shoulder region)
0.575 0.425 0.000
H43.0 Vitreous prolapse
0.575 0.425 0.000
E26 Hyperaldosteronism
0.575 0.425 0.000
L10-L14 Bullous disorders
0.574 0.426 0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.573 0.427 0.000
E23.1 Drug-induced hypopituitarism
0.573 0.427 0.000
H16.4 Corneal neovascularisation
0.572 0.428 0.000
K40.4 Unilateral or unspecified inguinal hernia, with gangrene
0.001 0.428 0.571
K40.1 Bilateral inguinal hernia, with gangrene
0.001 0.428 0.571
E23.6 Other disorders of pituitary gland
0.570 0.430 0.000
H17 Corneal scars and opacities
0.570 0.430 0.000
M23.8 Other internal derangements of knee
0.570 0.430 0.000
Q51 Congenital malformations of uterus and cervix
0.570 0.430 0.000
M32.1 Systemic lupus erythematosus with organ or system involvement
0.570 0.430 0.000
H19.1 Herpesviral keratitis and keratoconjunctivitis
0.568 0.432 0.000
M33.1 Other dermatomyositis
0.567 0.433 0.000
H43.2 Crystalline deposits in vitreous body
0.565 0.435 0.000
E07.1 Dyshormogenetic goitre
0.564 0.436 0.000
E07.0 Hypersecretion of calcitonin
0.564 0.436 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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