TreeWAS – Variant ID: rs9988450

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E78.0 Pure hypercholesterolaemia	0.000	0.000	1.000
E78.5 Hyperlipidaemia, unspecified	0.000	0.000	1.000
E78 Disorders of lipoprotein metabolism and other lipidaemias	0.000	0.000	1.000
E78.1 Pure hyperglyceridaemia	0.000	0.154	0.846
E78.6 Lipoprotein deficiency	0.000	0.270	0.730
E78.3 Hyperchylomicronaemia	0.000	0.283	0.717
E78.8 Other disorders of lipoprotein metabolism	0.000	0.299	0.701
E78.4 Other hyperlipidaemia	0.000	0.326	0.674
E89.0 Postprocedural hypothyroidism	0.000	0.442	0.558
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.000	0.458	0.542
E70-E90 Metabolic disorders	0.000	0.459	0.541
E78.2 Mixed hyperlipidaemia	0.000	0.486	0.514
E78.9 Disorder of lipoprotein metabolism, unspecified	0.000	0.541	0.459
E80 Disorders of porphyrin and bilirubin metabolism	0.000	0.579	0.421
E79 Disorders of purine and pyrimidine metabolism	0.000	0.581	0.419
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.000	0.588	0.412
E89.3 Postprocedural hypopituitarism	0.000	0.596	0.404
E87 Other disorders of fluid, electrolyte and acid-base balance	0.000	0.597	0.403
E87.6 Hypokalaemia	0.000	0.600	0.400
E84 Cystic fibrosis	0.000	0.603	0.397
E89.9 Postprocedural endocrine and metabolic disorder, unspecified	0.000	0.611	0.389
E89.8 Other postprocedural endocrine and metabolic disorders	0.000	0.611	0.389
E89.5 Postprocedural testicular hypofunction	0.000	0.611	0.389
E77 Disorders of glycoprotein metabolism	0.000	0.612	0.388
E76 Disorders of glycosaminoglycan metabolism	0.000	0.612	0.388
E72 Other disorders of amino-acid metabolism	0.000	0.612	0.388
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.000	0.612	0.388
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.000	0.612	0.388
E89.6 Postprocedural adrenocortical(-medullary) hypofunction	0.000	0.625	0.375
E85 Amyloidosis	0.000	0.639	0.361
E89.1 Postprocedural hypoinsulinaemia	0.000	0.648	0.352
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified	0.000	0.649	0.351
E87.5 Hyperkalaemia	0.000	0.666	0.334
E89.2 Postprocedural hypoparathyroidism	0.000	0.667	0.332
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease	0.000	0.668	0.332
E80.1 Porphyria cutanea tarda	0.000	0.670	0.330
E73 Lactose intolerance	0.000	0.670	0.330
E80.4 Gilbert's syndrome	0.000	0.680	0.320
E75.5 Other lipid storage disorders	0.000	0.681	0.319
E70 Disorders of aromatic amino-acid metabolism	0.000	0.685	0.315
E89.4 Postprocedural ovarian failure	0.000	0.691	0.308
E80.2 Other porphyria	0.000	0.696	0.303
E80.7 Disorder of bilirubin metabolism, unspecified	0.000	0.698	0.302
E80.5 Crigler-Najjar syndrome	0.000	0.698	0.302
E80.3 Defects of catalase and peroxydase	0.000	0.698	0.302
E80.0 Hereditary erythropoietic porphyria	0.000	0.698	0.302
E79.9 Disorder of purine and pyrimidine metabolism, unspecified	0.000	0.699	0.300
E79.8 Other disorders of purine and pyrimidine metabolism	0.000	0.699	0.300
E79.1 Lesch-Nyhan syndrome	0.000	0.699	0.300
E75.6 Lipid storage disorder, unspecified	0.000	0.705	0.295
E75.4 Neuronal ceroid lipofuscinosis	0.000	0.705	0.295
E75.3 Sphingolipidosis, unspecified	0.000	0.705	0.295
E75.2 Other sphingolipidosis	0.000	0.705	0.295
E75.1 Other gangliosidosis	0.000	0.705	0.295
E75.0 GM2 gangliosidosis	0.000	0.705	0.295
E84.9 Cystic fibrosis, unspecified	0.000	0.706	0.294
E87.4 Mixed disorder of acid-base balance	0.000	0.711	0.289
E80.6 Other disorders of bilirubin metabolism	0.000	0.713	0.287
E84.8 Cystic fibrosis with other manifestations	0.000	0.715	0.285
E84.1 Cystic fibrosis with intestinal manifestations	0.000	0.715	0.285
E84.0 Cystic fibrosis with pulmonary manifestations	0.000	0.715	0.285
E74 Other disorders of carbohydrate metabolism	0.000	0.718	0.281
E71.3 Disorders of fatty-acid metabolism	0.000	0.722	0.278
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified	0.000	0.722	0.278
E71.1 Other disorders of branched-chain amino-acid metabolism	0.000	0.722	0.278
E71.0 Maple-syrup-urine disease	0.000	0.722	0.278
E72.9 Disorder of amino-acid metabolism, unspecified	0.000	0.722	0.278
E72.8 Other specified disorders of amino-acid metabolism	0.000	0.722	0.278
E72.5 Disorders of glycine metabolism	0.000	0.722	0.278
E72.4 Disorders of ornithine metabolism	0.000	0.722	0.278
E72.3 Disorders of lysine and hydroxylysine metabolism	0.000	0.722	0.278
E72.2 Disorders of urea cycle metabolism	0.000	0.722	0.278
E72.1 Disorders of sulphur-bearing amino-acid metabolism	0.000	0.722	0.278
E72.0 Disorders of amino-acid transport	0.000	0.722	0.278
E76.9 Disorder of glucosaminoglycan metabolism, unspecified	0.000	0.722	0.278
E76.8 Other disorders of glucosaminoglycan metabolism	0.000	0.722	0.278
E76.3 Mucopolysaccharidosis, unspecified	0.000	0.722	0.278
E76.2 Other mucopolysaccharidoses	0.000	0.722	0.278
E76.1 Mucopolysaccharidosis, type II	0.000	0.722	0.278
E76.0 Mucopolysaccharidosis, type I	0.000	0.722	0.278
E77.9 Disorder of glycoprotein metabolism, unspecified	0.000	0.722	0.278
E77.8 Other disorders of glycoprotein metabolism	0.000	0.722	0.278
E77.1 Defects in glycoprotein degradation	0.000	0.722	0.278
E77.0 Defects in posttranslational modification of lysosomal enzymes	0.000	0.722	0.278
E85.3 Secondary systemic amyloidosis	0.000	0.726	0.274
E85.8 Other amyloidosis	0.000	0.741	0.259
E85.2 Heredofamilial amyloidosis, unspecified	0.000	0.741	0.259
E85.1 Neuropathic heredofamilial amyloidosis	0.000	0.741	0.259
E85.0 Nonneuropathic heredofamilial amyloidosis	0.000	0.741	0.259
E85.9 Amyloidosis, unspecified	0.000	0.753	0.246
E73.8 Other lactose intolerance	0.000	0.763	0.236
E73.1 Secondary lactase deficiency	0.000	0.763	0.236
E73.0 Congenital lactase deficiency	0.000	0.763	0.236
E70.9 Disorder of aromatic amino-acid metabolism, unspecified	0.000	0.774	0.226
E70.8 Other disorders of aromatic amino-acid metabolism	0.000	0.774	0.226
E70.2 Disorders of tyrosine metabolism	0.000	0.774	0.226
E70.1 Other hyperphenylalaninaemias	0.000	0.774	0.226
E70.0 Classical phenylketonuria	0.000	0.774	0.226
E85.4 Organ-limited amyloidosis	0.000	0.775	0.225
E87.0 Hyperosmolality and hypernatraemia	0.000	0.797	0.203
E88 Other metabolic disorders	0.000	0.798	0.202
E74.9 Disorder of carbohydrate metabolism, unspecified	0.000	0.798	0.202
E74.8 Other specified disorders of carbohydrate metabolism	0.000	0.798	0.202
E74.4 Disorders of pyruvate metabolism and gluconeogenesis	0.000	0.798	0.202
E74.2 Disorders of galactose metabolism	0.000	0.798	0.202
E74.1 Disorders of fructose metabolism	0.000	0.798	0.202
E87.3 Alkalosis	0.000	0.805	0.195
E73.9 Lactose intolerance, unspecified	0.000	0.822	0.178
E87.7 Fluid overload	0.000	0.828	0.172
E74.3 Other disorders of intestinal carbohydrate absorption	0.000	0.840	0.160
E74.0 Glycogen storage disease	0.001	0.840	0.159
E70.3 Albinism	0.001	0.846	0.153
E88.1 Lipodystrophy, not elsewhere classified	0.000	0.855	0.145
E88.3 Tumour lysis syndrome	0.000	0.856	0.144
E88.8 Other specified metabolic disorders	0.000	0.862	0.138
E88.9 Metabolic disorder, unspecified	0.000	0.864	0.136
E83 Disorders of mineral metabolism	0.000	0.869	0.131
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified	0.000	0.890	0.110
E83.9 Disorder of mineral metabolism, unspecified	0.000	0.906	0.094
E83.8 Other disorders of mineral metabolism	0.000	0.906	0.094
E83.2 Disorders of zinc metabolism	0.000	0.906	0.094
E83.0 Disorders of copper metabolism	0.000	0.906	0.094
E83.5 Disorders of calcium metabolism	0.000	0.909	0.091
E83.4 Disorders of magnesium metabolism	0.000	0.909	0.091
E88.2 Lipomatosis, not elsewhere classified	0.001	0.911	0.088
E10.3 With ophthalmic complications	0.000	0.936	0.064
E10 Insulin-dependent diabetes mellitus	0.000	0.938	0.062
E10.6 With other specified complications	0.000	0.943	0.057
E10.0 With coma	0.000	0.945	0.055
E10.9 Without complications	0.000	0.948	0.052
E87.1 Hypo-osmolality and hyponatraemia	0.000	0.949	0.051
E83.3 Disorders of phosphorus metabolism	0.000	0.951	0.049
E10.4 With neurological complications	0.000	0.951	0.049
Chapter IV Endocrine, nutritional and metabolic diseases	0.000	0.951	0.049
E10-E14 Diabetes mellitus	0.000	0.951	0.049
E86 Volume depletion	0.000	0.952	0.048
E10.1 With ketoacidosis	0.000	0.955	0.045
E10.7 With multiple complications	0.000	0.955	0.045
E10.5 With peripheral circulatory complications	0.000	0.958	0.042
E87.2 Acidosis	0.000	0.958	0.042
G45.9 Transient cerebral ischaemic attack, unspecified	0.039	0.961	0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.000	0.963	0.037
E12 Malnutrition-related diabetes mellitus	0.000	0.965	0.035
E13 Other specified diabetes mellitus	0.000	0.966	0.033
E10.8 With unspecified complications	0.000	0.967	0.033
E10.2 With renal complications	0.000	0.968	0.032
E40-E46 Malnutrition	0.000	0.970	0.030
E16 Other disorders of pancreatic internal secretion	0.000	0.972	0.028
E16.0 Drug-induced hypoglycaemia without coma	0.000	0.973	0.027
E15 Nondiabetic hypoglycaemic coma	0.000	0.973	0.026
E12.9 Without complications	0.000	0.975	0.025
E12.8 With unspecified complications	0.000	0.975	0.025
E12.7 With multiple complications	0.000	0.975	0.025
E12.6 With other specified complications	0.000	0.975	0.025
E12.5 With peripheral circulatory complications	0.000	0.975	0.025
E12.4 With neurological complications	0.000	0.975	0.025
E12.3 With ophthalmic complications	0.000	0.975	0.025
E12.2 With renal complications	0.000	0.975	0.025
E12.1 With ketoacidosis	0.000	0.975	0.025
E12.0 With coma	0.000	0.975	0.025
M80.98 Unspecified osteoporosis with pathological fracture (Other)	0.025	0.975	0.000
E13.3 With ophthalmic complications	0.000	0.976	0.024
E13.8 With unspecified complications	0.000	0.976	0.024
E13.7 With multiple complications	0.000	0.976	0.024
E13.6 With other specified complications	0.000	0.976	0.024
E13.5 With peripheral circulatory complications	0.000	0.976	0.024
E13.4 With neurological complications	0.000	0.976	0.024
E13.2 With renal complications	0.000	0.976	0.024
E13.1 With ketoacidosis	0.000	0.976	0.024
E13.0 With coma	0.000	0.976	0.024
M80.9 Unspecified osteoporosis with pathological fracture	0.024	0.976	0.000
E65-E68 Obesity and other hyperalimentation	0.000	0.976	0.024
E14 Unspecified diabetes mellitus	0.000	0.977	0.023
M80.90 Unspecified osteoporosis with pathological fracture (Multiple sites)	0.023	0.977	0.000
E13.9 Without complications	0.000	0.977	0.022
E44 Protein-energy malnutrition of moderate and mild degree	0.000	0.978	0.022
E45 Retarded development following protein-energy malnutrition	0.000	0.978	0.022
E43 Unspecified severe protein-energy malnutrition	0.000	0.978	0.022
E42 Marasmic kwashiorkor	0.000	0.978	0.022
E41 Nutritional marasmus	0.000	0.978	0.022
E40 Kwashiorkor	0.000	0.978	0.022
E16.9 Disorder of pancreatic internal secretion, unspecified	0.000	0.980	0.020
E16.8 Other specified disorders of pancreatic internal secretion	0.000	0.980	0.020
E16.4 Abnormal secretion of gastrin	0.000	0.980	0.020
E16.3 Increased secretion of glucagon	0.000	0.980	0.020
E14.3 With ophthalmic complications	0.000	0.980	0.020
G45 Transient cerebral ischaemic attacks and related syndromes	0.020	0.980	0.000
M80.99 Unspecified osteoporosis with pathological fracture (Site unspecified)	0.020	0.980	0.000
G43.9 Migraine, unspecified	0.020	0.980	0.000
E16.1 Other hypoglycaemia	0.000	0.980	0.019
M35.0 Sicca syndrome [Sjogren]	0.019	0.981	0.000
M80 Osteoporosis with pathological fracture	0.019	0.981	0.000
M80.10 Postoophorectomy osteoporosis with pathological fracture (Multiple sites)	0.018	0.982	0.000
M80.1 Postoophorectomy osteoporosis with pathological fracture	0.018	0.982	0.000
E65 Localised adiposity	0.000	0.982	0.018
E14.2 Withrenal complications	0.000	0.982	0.018
G43 Migraine	0.018	0.982	0.000
M80.97 Unspecified osteoporosis with pathological fracture (Ankle and foot)	0.017	0.982	0.000
M80.96 Unspecified osteoporosis with pathological fracture (Lower leg)	0.017	0.982	0.000
M80.95 Unspecified osteoporosis with pathological fracture (Pelvic region and thigh)	0.017	0.982	0.000
M80.94 Unspecified osteoporosis with pathological fracture (Hand)	0.017	0.982	0.000
M80.93 Unspecified osteoporosis with pathological fracture (Forearm)	0.017	0.982	0.000
M80.92 Unspecified osteoporosis with pathological fracture (Upper arm)	0.017	0.982	0.000
M80.91 Unspecified osteoporosis with pathological fracture (Shoulder region)	0.017	0.982	0.000
E83.1 Disorders of iron metabolism	0.000	0.982	0.017
E14.6 With other specified complications	0.000	0.983	0.017
E67 Other hyperalimentation	0.000	0.983	0.017
E68 Sequelae of hyperalimentation	0.000	0.983	0.017
G56.2 Lesion of ulnar nerve	0.017	0.983	0.000
E46 Unspecified protein-energy malnutrition	0.000	0.983	0.017
G56.8 Other mononeuropathies of upper limb	0.017	0.983	0.000
E14.7 With multiple complications	0.000	0.983	0.017
E14.0 With coma	0.000	0.983	0.017
E14.5 With peripheral circulatory complications	0.000	0.984	0.016
E44.1 Mild protein-energy malnutrition	0.000	0.984	0.016
E44.0 Moderate protein-energy malnutrition	0.000	0.984	0.016
G40-G47 Episodic and paroxysmal disorders	0.016	0.984	0.000
G43.8 Other migraine	0.016	0.984	0.000
E14.8 With unspecified complications	0.000	0.984	0.016
G56.3 Lesion of radial nerve	0.016	0.984	0.000
G56 Mononeuropathies of upper limb	0.016	0.984	0.000
E14.4 With neurological complications	0.000	0.984	0.016
G40.9 Epilepsy, unspecified	0.015	0.985	0.000
G45.0 Vertebro-basilar artery syndrome	0.015	0.985	0.000
G45.2 Multiple and bilateral precerebral artery syndromes	0.014	0.986	0.000
G40 Epilepsy	0.014	0.986	0.000
M80.5 Idiopathic osteoporosis with pathological fracture	0.014	0.986	0.000
G45.8 Other transient cerebral ischaemic attacks and related syndromes	0.014	0.986	0.000
Q60.0 Renal agenesis, unilateral	0.014	0.986	0.000
M80.4 Drug-induced osteoporosis with pathological fracture	0.013	0.986	0.000
M80.3 Postsurgical malabsorption osteoporosis with pathological fracture	0.013	0.986	0.000
M80.2 Osteoporosis of disuse with pathological fracture	0.013	0.986	0.000
M80.19 Postoophorectomy osteoporosis with pathological fracture (Site unspecified)	0.013	0.987	0.000
M80.18 Postoophorectomy osteoporosis with pathological fracture (Other)	0.013	0.987	0.000
M80.17 Postoophorectomy osteoporosis with pathological fracture (Ankle and foot)	0.013	0.987	0.000
M80.16 Postoophorectomy osteoporosis with pathological fracture (Lower leg)	0.013	0.987	0.000
M80.15 Postoophorectomy osteoporosis with pathological fracture (Pelvic region and thigh)	0.013	0.987	0.000
M80.14 Postoophorectomy osteoporosis with pathological fracture (Hand)	0.013	0.987	0.000
M80.13 Postoophorectomy osteoporosis with pathological fracture (Forearm)	0.013	0.987	0.000
M80.12 Postoophorectomy osteoporosis with pathological fracture (Upper arm)	0.013	0.987	0.000
M80.11 Postoophorectomy osteoporosis with pathological fracture (Shoulder region)	0.013	0.987	0.000
M80.8 Other osteoporosis with pathological fracture	0.013	0.987	0.000
G40.6 Grand mal seizures, unspecified (with or without petit mal)	0.013	0.987	0.000
E50-E64 Other nutritional deficiencies	0.000	0.987	0.013
G43.2 Status migrainosus	0.013	0.987	0.000
E67.8 Other specified hyperalimentation	0.000	0.987	0.012
E67.3 Hypervitaminosis D	0.000	0.987	0.012
E67.2 Megavitamin-B6 syndrome	0.000	0.987	0.012
E67.1 Hypercarotenaemia	0.000	0.987	0.012
E67.0 Hypervitaminosis A	0.000	0.987	0.012
G43.0 Migraine without aura [common migraine]	0.012	0.988	0.000
G45.1 Carotid artery syndrome (hemispheric)	0.012	0.988	0.000
G56.1 Other lesions of median nerve	0.012	0.988	0.000
G43.3 Complicated migraine	0.012	0.988	0.000
E14.1 With ketoacidosis	0.000	0.988	0.012
M80.52 Idiopathic osteoporosis with pathological fracture (Upper arm)	0.012	0.988	0.000
M07.30 Other psoriatic arthropathies (Multiple sites)	0.012	0.988	0.000
G45.4 Transient global amnesia	0.012	0.988	0.000
G46 Vascular syndromes of brain in cerebrovascular diseases	0.011	0.989	0.000
G44 Other headache syndromes	0.011	0.989	0.000
G43.1 Migraine with aura [classical migraine]	0.011	0.989	0.000
G40.4 Other generalised epilepsy and epileptic syndromes	0.011	0.989	0.000
M80.81 Other osteoporosis with pathological fracture (Shoulder region)	0.010	0.989	0.000
G56.4 Causalgia	0.010	0.989	0.000
Q60 Renal agenesis and other reduction defects of kidney	0.010	0.990	0.000
M80.59 Idiopathic osteoporosis with pathological fracture (Site unspecified)	0.010	0.990	0.000
M80.58 Idiopathic osteoporosis with pathological fracture (Other)	0.010	0.990	0.000
M80.57 Idiopathic osteoporosis with pathological fracture (Ankle and foot)	0.010	0.990	0.000
M80.56 Idiopathic osteoporosis with pathological fracture (Lower leg)	0.010	0.990	0.000
M80.55 Idiopathic osteoporosis with pathological fracture (Pelvic region and thigh)	0.010	0.990	0.000
M80.54 Idiopathic osteoporosis with pathological fracture (Hand)	0.010	0.990	0.000
M80.53 Idiopathic osteoporosis with pathological fracture (Forearm)	0.010	0.990	0.000
M80.51 Idiopathic osteoporosis with pathological fracture (Shoulder region)	0.010	0.990	0.000
G45.3 Amaurosis fugax	0.010	0.990	0.000
E56 Other vitamin deficiencies	0.000	0.990	0.010
M80.0 Postmenopausal osteoporosis with pathological fracture	0.010	0.990	0.000
C44.5 Skin of trunk	0.010	0.990	0.000
M80.29 Osteoporosis of disuse with pathological fracture (Site unspecified)	0.010	0.990	0.000
M80.28 Osteoporosis of disuse with pathological fracture (Other)	0.010	0.990	0.000
M80.27 Osteoporosis of disuse with pathological fracture (Ankle and foot)	0.010	0.990	0.000
M80.26 Osteoporosis of disuse with pathological fracture (Lower leg)	0.010	0.990	0.000
M80.25 Osteoporosis of disuse with pathological fracture (Pelvic region and thigh)	0.010	0.990	0.000
M80.24 Osteoporosis of disuse with pathological fracture (Hand)	0.010	0.990	0.000
M80.23 Osteoporosis of disuse with pathological fracture (Forearm)	0.010	0.990	0.000
M80.22 Osteoporosis of disuse with pathological fracture (Upper arm)	0.010	0.990	0.000
M80.21 Osteoporosis of disuse with pathological fracture (Shoulder region)	0.010	0.990	0.000
M80.20 Osteoporosis of disuse with pathological fracture (Multiple sites)	0.010	0.990	0.000
M80.39 Postsurgical malabsorption osteoporosis with pathological fracture (Site unspecified)	0.010	0.990	0.000
M80.38 Postsurgical malabsorption osteoporosis with pathological fracture (Other)	0.010	0.990	0.000
M80.37 Postsurgical malabsorption osteoporosis with pathological fracture (Ankle and foot)	0.010	0.990	0.000
M80.36 Postsurgical malabsorption osteoporosis with pathological fracture (Lower leg)	0.010	0.990	0.000
M80.35 Postsurgical malabsorption osteoporosis with pathological fracture (Pelvic region and thigh)	0.010	0.990	0.000
M80.34 Postsurgical malabsorption osteoporosis with pathological fracture (Hand)	0.010	0.990	0.000
M80.33 Postsurgical malabsorption osteoporosis with pathological fracture (Forearm)	0.010	0.990	0.000
M80.32 Postsurgical malabsorption osteoporosis with pathological fracture (Upper arm)	0.010	0.990	0.000
M80.31 Postsurgical malabsorption osteoporosis with pathological fracture (Shoulder region)	0.010	0.990	0.000
M80.30 Postsurgical malabsorption osteoporosis with pathological fracture (Multiple sites)	0.010	0.990	0.000
M80.49 Drug-induced osteoporosis with pathological fracture (Site unspecified)	0.010	0.990	0.000
M80.48 Drug-induced osteoporosis with pathological fracture (Other)	0.010	0.990	0.000
M80.47 Drug-induced osteoporosis with pathological fracture (Ankle and foot)	0.010	0.990	0.000
M80.46 Drug-induced osteoporosis with pathological fracture (Lower leg)	0.010	0.990	0.000
M80.45 Drug-induced osteoporosis with pathological fracture (Pelvic region and thigh)	0.010	0.990	0.000
M80.44 Drug-induced osteoporosis with pathological fracture (Hand)	0.010	0.990	0.000
M80.43 Drug-induced osteoporosis with pathological fracture (Forearm)	0.010	0.990	0.000
M80.42 Drug-induced osteoporosis with pathological fracture (Upper arm)	0.010	0.990	0.000
M80.41 Drug-induced osteoporosis with pathological fracture (Shoulder region)	0.010	0.990	0.000
M80.40 Drug-induced osteoporosis with pathological fracture (Multiple sites)	0.010	0.990	0.000
G56.9 Mononeuropathy of upper limb, unspecified	0.010	0.990	0.000
G44.0 Cluster headache syndrome	0.010	0.990	0.000
G40.0 Localisation-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localised onset	0.010	0.990	0.000
M07.39 Other psoriatic arthropathies (Site unspecified)	0.010	0.990	0.000
M80.89 Other osteoporosis with pathological fracture (Site unspecified)	0.009	0.990	0.000
M80.87 Other osteoporosis with pathological fracture (Ankle and foot)	0.009	0.990	0.000
M80.86 Other osteoporosis with pathological fracture (Lower leg)	0.009	0.990	0.000
M80.85 Other osteoporosis with pathological fracture (Pelvic region and thigh)	0.009	0.990	0.000
M80.84 Other osteoporosis with pathological fracture (Hand)	0.009	0.990	0.000
M80.83 Other osteoporosis with pathological fracture (Forearm)	0.009	0.990	0.000
M80.82 Other osteoporosis with pathological fracture (Upper arm)	0.009	0.990	0.000
M80.80 Other osteoporosis with pathological fracture (Multiple sites)	0.009	0.990	0.000
E64 Sequelae of malnutrition and other nutritional deficiencies	0.000	0.990	0.010
E50 Vitamin A deficiency	0.000	0.990	0.010
E60 Dietary zinc deficiency	0.000	0.990	0.010
E59 Dietary selenium deficiency	0.000	0.990	0.010
E54 Ascorbic acid deficiency	0.000	0.990	0.010
E52 Niacin deficiency [pellagra]	0.000	0.990	0.010
G40.3 Generalised idiopathic epilepsy and epileptic syndromes	0.010	0.990	0.000
M07.3 Other psoriatic arthropathies	0.010	0.990	0.000
Q20-Q28 Congenital malformations of the circulatory system	0.010	0.990	0.000
G40.8 Other epilepsy	0.009	0.991	0.000
G41 Status epilepticus	0.009	0.991	0.000
E63 Other nutritional deficiencies	0.000	0.991	0.009
Q23 Congenital malformations of aortic and mitral valves	0.009	0.991	0.000
G40.1 Localisation-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures	0.009	0.991	0.000
G44.1 Vascular headache, not elsewhere classified	0.009	0.991	0.000
Q24 Other congenital malformations of heart	0.009	0.991	0.000
E58 Dietary calcium deficiency	0.000	0.991	0.009
Q25 Congenital malformations of great arteries	0.009	0.991	0.000
M80.50 Idiopathic osteoporosis with pathological fracture (Multiple sites)	0.009	0.991	0.000
Q24.9 Congenital malformation of the heart, unspecified	0.009	0.991	0.000
G44.4 Drug-induced headache, not elsewhere classified	0.009	0.991	0.000
E04.2 Non-toxic multinodular goitre	0.009	0.991	0.000
Q23.1 Congenital insufficiency of aortic valve	0.009	0.991	0.000
G44.8 Other specified headache syndromes	0.008	0.991	0.000
E51 Thiamine deficiency	0.000	0.992	0.008
G46.8 Other vascular syndromes of brain in cerebrovascular diseases	0.008	0.992	0.000
G46.6 Pure sensory lacunar syndrome	0.008	0.992	0.000
G46.5 Pure motor lacunar syndrome	0.008	0.992	0.000
G46.3 Brain stem stroke syndrome	0.008	0.992	0.000
G46.2 Posterior cerebral artery syndrome	0.008	0.992	0.000
G46.1 Anterior cerebral artery syndrome	0.008	0.992	0.000
G46.0 Middle cerebral artery syndrome	0.008	0.992	0.000
G46.4 Cerebellar stroke syndrome	0.008	0.992	0.000
Z75.1 Person awaiting admission to adequate facility elsewhere	0.008	0.992	0.000
Q22 Congenital malformations of pulmonary and tricuspid valves	0.008	0.992	0.000
M80.88 Other osteoporosis with pathological fracture (Other)	0.008	0.992	0.000
Q60.2 Renal agenesis, unspecified	0.008	0.992	0.000
E56.1 Deficiency of vitamin K	0.000	0.992	0.008
G46.7 Other lacunar syndromes	0.008	0.992	0.000
G44.3 Chronic posttraumatic headache	0.008	0.992	0.000
Q26 Congenital malformations of great veins	0.008	0.992	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.008	0.992	0.000
G40.7 Petit mal, unspecified, without grand mal seizures	0.008	0.992	0.000
Q60.6 Potter's syndrome	0.008	0.992	0.000
Q60.5 Renal hypoplasia, unspecified	0.008	0.992	0.000
Q60.4 Renal hypoplasia, bilateral	0.008	0.992	0.000
Q60.3 Renal hypoplasia, unilateral	0.008	0.992	0.000
Q60.1 Renal agenesis, bilateral	0.008	0.992	0.000
M07.34 Other psoriatic arthropathies (Hand)	0.008	0.992	0.000
Q60-Q64 Congenital malformations of the urinary system	0.008	0.992	0.000
G40.5 Special epileptic syndromes	0.007	0.992	0.000
Q24.4 Congenital subaortic stenosis	0.008	0.992	0.000
E56.9 Vitamin deficiency, unspecified	0.000	0.992	0.007
E56.8 Deficiency of other vitamins	0.000	0.992	0.007
E56.0 Deficiency of vitamin E	0.000	0.992	0.007
M07.31 Other psoriatic arthropathies (Shoulder region)	0.007	0.992	0.000
M80.09 Postmenopausal osteoporosis with pathological fracture (Site unspecified)	0.007	0.992	0.000
M80.08 Postmenopausal osteoporosis with pathological fracture (Other)	0.007	0.992	0.000
M80.07 Postmenopausal osteoporosis with pathological fracture (Ankle and foot)	0.007	0.992	0.000
M80.06 Postmenopausal osteoporosis with pathological fracture (Lower leg)	0.007	0.992	0.000
M80.05 Postmenopausal osteoporosis with pathological fracture (Pelvic region and thigh)	0.007	0.992	0.000
M80.04 Postmenopausal osteoporosis with pathological fracture (Hand)	0.007	0.992	0.000
M80.03 Postmenopausal osteoporosis with pathological fracture (Forearm)	0.007	0.992	0.000
M80.02 Postmenopausal osteoporosis with pathological fracture (Upper arm)	0.007	0.992	0.000
M80.01 Postmenopausal osteoporosis with pathological fracture (Shoulder region)	0.007	0.992	0.000
G41.8 Other status epilepticus	0.007	0.992	0.000
Q25.3 Stenosis of aorta	0.007	0.993	0.000
Q25.0 Patent ductus arteriosus	0.007	0.993	0.000
Q23.0 Congenital stenosis of aortic valve	0.007	0.993	0.000
Q50-Q56 Congenital malformations of genital organs	0.007	0.993	0.000
Q22.5 Ebstein's anomaly	0.007	0.993	0.000
E61 Deficiency of other nutrient elements	0.000	0.993	0.007
Q25.6 Stenosis of pulmonary artery	0.007	0.993	0.000
E55 Vitamin D deficiency	0.000	0.993	0.007
E50.9 Vitamin A deficiency, unspecified	0.000	0.993	0.007
E50.8 Other manifestations of vitamin A deficiency	0.000	0.993	0.007
E50.7 Other ocular manifestations of vitamin A deficiency	0.000	0.993	0.007
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea	0.000	0.993	0.007
E50.5 Vitamin A deficiency with night blindness	0.000	0.993	0.007
E50.4 Vitamin A deficiency with keratomalacia	0.000	0.993	0.007
E50.3 Vitamin A deficiency with corneal ulceration and xerosis	0.000	0.993	0.007
E50.2 Vitamin A deficiency with corneal xerosis	0.000	0.993	0.007
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis	0.000	0.993	0.007
E50.0 Vitamin A deficiency with conjunctival xerosis	0.000	0.993	0.007
E64.9 Sequelae of unspecified nutritional deficiency	0.000	0.993	0.007
E64.8 Sequelae of other nutritional deficiencies	0.000	0.993	0.007
E64.3 Sequelae of rickets	0.000	0.993	0.007
E64.2 Sequelae of vitamin C deficiency	0.000	0.993	0.007
E64.1 Sequelae of vitamin A deficiency	0.000	0.993	0.007
E64.0 Sequelae of protein-energy malnutrition	0.000	0.993	0.007
M07.33 Other psoriatic arthropathies (Forearm)	0.007	0.993	0.000
M07.32 Other psoriatic arthropathies (Upper arm)	0.007	0.993	0.000
M07.38 Other psoriatic arthropathies (Other)	0.007	0.993	0.000
Q24.5 Malformation of coronary vessels	0.007	0.993	0.000
Q20 Congenital malformations of cardiac chambers and connexions	0.007	0.993	0.000
Q24.0 Dextrocardia	0.007	0.993	0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.007	0.993	0.000
G41.1 Petit mal status epilepticus	0.007	0.993	0.000
O03.4 Incomplete, without complication	0.007	0.993	0.000
M80-M85 Disorders of bone density and structure	0.007	0.993	0.000
M84.06 Malunion of fracture (Lower leg)	0.007	0.993	0.000
E63.8 Other specified nutritional deficiencies	0.000	0.993	0.007
E63.1 Imbalance of constituents of food intake	0.000	0.993	0.007
E63.0 Essential fatty acid [EFA] deficiency	0.000	0.993	0.007
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)	0.007	0.993	0.000
Q23.3 Congenital mitral insufficiency	0.007	0.993	0.000
Q21 Congenital malformations of cardiac septa	0.007	0.993	0.000
M84.0 Malunion of fracture	0.007	0.993	0.000
G41.0 Grand mal status epilepticus	0.007	0.993	0.000
E53 Deficiency of other B group vitamins	0.000	0.993	0.007
E00-E07 Disorders of thyroid gland	0.001	0.993	0.006
Q24.6 Congenital heart block	0.007	0.993	0.000
Q23.9 Congenital malformation of aortic and mitral valves, unspecified	0.007	0.993	0.000
Q23.8 Other congenital malformations of aortic and mitral valves	0.007	0.993	0.000
Q23.4 Hypoplastic left heart syndrome	0.007	0.993	0.000
Q23.2 Congenital mitral stenosis	0.007	0.993	0.000
G41.2 Complex partial status epilepticus	0.007	0.993	0.000
Q26.4 Anomalous pulmonary venous connexion, unspecified	0.007	0.993	0.000
Q53 Undescended testicle	0.007	0.993	0.000
Q24.3 Pulmonary infundibular stenosis	0.007	0.993	0.000
Q24.2 Cor triatriatum	0.007	0.993	0.000
Q24.1 Levocardia	0.007	0.993	0.000
Q74 Other congenital malformations of limb(s)	0.007	0.993	0.000
R21 Rash and other nonspecific skin eruption	0.000	0.993	0.007
K31.1 Adult hypertrophic pyloric stenosis	0.007	0.993	0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.007	0.993	0.000
E63.9 Nutritional deficiency, unspecified	0.000	0.993	0.006
Q21.1 Atrial septal defect	0.007	0.993	0.000
Q25.7 Other congenital malformations of pulmonary artery	0.006	0.993	0.000
H90.5 Sensorineural hearing loss, unspecified	0.000	0.993	0.007
Q25.9 Congenital malformation of great arteries, unspecified	0.006	0.993	0.000
Q25.8 Other congenital malformations of great arteries	0.006	0.993	0.000
Q25.5 Atresia of pulmonary artery	0.006	0.993	0.000
Q25.2 Atresia of aorta	0.006	0.993	0.000
Q25.1 Coarctation of aorta	0.006	0.993	0.000
S06.60 Traumatic subarachnoid haemorrhage (without open intracranial wound)	0.000	0.993	0.007
H90.0 Conductive hearing loss, bilateral	0.000	0.994	0.006
Q22.1 Congenital pulmonary valve stenosis	0.006	0.994	0.000
E03.9 Hypothyroidism, unspecified	0.000	0.994	0.006
Q30-Q34 Congenital malformations of the respiratory system	0.006	0.994	0.000
E51.9 Thiamine deficiency, unspecified	0.000	0.994	0.006
E51.8 Other manifestations of thiamine deficiency	0.000	0.994	0.006
E51.1 Beriberi	0.000	0.994	0.006
H90 Conductive and sensorineural hearing loss	0.000	0.994	0.006
S82.20 Fracture of shaft of tibia (closed)	0.006	0.994	0.000
Q64 Other congenital malformations of urinary system	0.006	0.994	0.000
H36.0 Diabetic retinopathy	0.000	0.994	0.006
Q22.9 Congenital malformation of tricuspid valve, unspecified	0.006	0.994	0.000
Q22.8 Other congenital malformations of tricuspid valve	0.006	0.994	0.000
Q22.6 Hypoplastic right heart syndrome	0.006	0.994	0.000
Q22.4 Congenital tricuspid stenosis	0.006	0.994	0.000
Q22.3 Other congenital malformations of pulmonary valve	0.006	0.994	0.000
Q22.2 Congenital pulmonary valve insufficiency	0.006	0.994	0.000
Q22.0 Pulmonary valve atresia	0.006	0.994	0.000
Q52 Other congenital malformations of female genitalia	0.006	0.994	0.000
M84 Disorders of continuity of bone	0.006	0.994	0.000
M84.01 Malunion of fracture (Shoulder region)	0.006	0.994	0.000
E03 Other hypothyroidism	0.000	0.994	0.006
Q51 Congenital malformations of uterus and cervix	0.006	0.994	0.000
Q25.4 Other congenital malformations of aorta	0.006	0.994	0.000
M84.03 Malunion of fracture (Forearm)	0.006	0.994	0.000
Q55 Other congenital malformations of male genital organs	0.006	0.994	0.000
M07 Psoriatic and enteropathic arthropathies	0.006	0.994	0.000
Q74.1 Congenital malformation of knee	0.006	0.994	0.000
Q35-Q37 Cleft lip and cleft palate	0.006	0.994	0.000
Q26.9 Congenital malformation of great vein, unspecified	0.006	0.994	0.000
Q26.8 Other congenital malformations of great veins	0.006	0.994	0.000
Q26.6 Portal vein-hepatic artery fistula	0.006	0.994	0.000
Q26.5 Anomalous portal venous connexion	0.006	0.994	0.000
Q26.3 Partial anomalous pulmonary venous connexion	0.006	0.994	0.000
Q26.2 Total anomalous pulmonary venous connexion	0.006	0.994	0.000
Q26.1 Persistent left superior vena cava	0.006	0.994	0.000
Q26.0 Congenital stenosis of vena cava	0.006	0.994	0.000
Q53.9 Undescended testicle, unspecified	0.006	0.994	0.000
S22.40 Multiple fractures of ribs (closed)	0.000	0.994	0.006
Q65 Congenital deformities of hip	0.006	0.994	0.000
H90.8 Mixed conductive and sensorineural hearing loss, unspecified	0.000	0.994	0.006
Q12 Congenital lens malformations	0.006	0.994	0.000
Q68 Other congenital musculoskeletal deformities	0.006	0.994	0.000
H90.6 Mixed conductive and sensorineural hearing loss, bilateral	0.000	0.994	0.006
Q53.2 Undescended testicle, bilateral	0.006	0.994	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations