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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

Affx-28451893
log Bayes Factor = 56.8781
Chromosome 6   position 31,318,303  (GRCh37) Explore Affx-28451893 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
L40 Psoriasis
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.001 0.999
E10.3 With ophthalmic complications
0.000 0.001 0.999
E78.0 Pure hypercholesterolaemia
0.000 0.003 0.997
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.004 0.996
I25.1 Atherosclerotic heart disease
0.000 0.006 0.994
E70-E90 Metabolic disorders
0.000 0.007 0.993
E14 Unspecified diabetes mellitus
0.000 0.007 0.993
M06.9 Rheumatoid arthritis, unspecified
0.000 0.011 0.989
I25.2 Old myocardial infarction
0.000 0.012 0.988
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.014 0.986
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.018 0.982
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.021 0.979
I20 Angina pectoris
0.000 0.021 0.979
I21 Acute myocardial infarction
0.000 0.023 0.977
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.024 0.976
I20.9 Angina pectoris, unspecified
0.000 0.026 0.974
E14.9 Without complications
0.000 0.029 0.971
G35-G37 Demyelinating diseases of the central nervous system
0.964 0.036 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.037 0.963
I21.9 Acute myocardial infarction, unspecified
0.000 0.041 0.959
E10.1 With ketoacidosis
0.000 0.041 0.959
E05.9 Thyrotoxicosis, unspecified
0.000 0.046 0.954
E11 Non-insulin-dependent diabetes mellitus
0.000 0.048 0.952
I25.5 Ischaemic cardiomyopathy
0.000 0.050 0.950
L40-L45 Papulosquamous disorders
0.000 0.062 0.938
E11.9 Without complications
0.000 0.065 0.935
G37 Other demyelinating diseases of central nervous system
0.930 0.070 0.000
E14.3 With ophthalmic complications
0.000 0.072 0.928
L43 Lichen planus
0.000 0.078 0.922
I24 Other acute ischaemic heart diseases
0.000 0.084 0.916
E78.2 Mixed hyperlipidaemia
0.000 0.089 0.911
L43.9 Lichen planus, unspecified
0.000 0.092 0.908
G37.9 Demyelinating disease of central nervous system, unspecified
0.906 0.094 0.000
I22 Subsequent myocardial infarction
0.000 0.098 0.902
E78.8 Other disorders of lipoprotein metabolism
0.000 0.122 0.878
E11.1 With ketoacidosis
0.000 0.124 0.876
L40.0 Psoriasis vulgaris
0.000 0.137 0.863
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.138 0.862
E13 Other specified diabetes mellitus
0.000 0.146 0.854
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.147 0.853
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.149 0.851
E10.4 With neurological complications
0.000 0.169 0.831
E10.5 With peripheral circulatory complications
0.000 0.173 0.827
I25.3 Aneurysm of heart
0.000 0.175 0.825
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.181 0.819
E74 Other disorders of carbohydrate metabolism
0.000 0.181 0.819
E10.2 With renal complications
0.000 0.184 0.816
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.187 0.813
E10.8 With unspecified complications
0.000 0.187 0.812
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.190 0.810
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.195 0.805
E20-E35 Disorders of other endocrine glands
0.000 0.202 0.798
I23 Certain current complications following acute myocardial infarction
0.000 0.208 0.792
L40.8 Other psoriasis
0.000 0.209 0.791
E10.6 With other specified complications
0.000 0.211 0.789
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.218 0.782
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.220 0.780
E78.4 Other hyperlipidaemia
0.000 0.227 0.772
E10.0 With coma
0.000 0.236 0.763
E11.0 With coma
0.000 0.237 0.763
G37.8 Other specified demyelinating diseases of central nervous system
0.750 0.250 0.000
E13.9 Without complications
0.000 0.251 0.749
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.254 0.746
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.258 0.742
Chapter VI Diseases of the nervous system
0.739 0.261 0.000
E85 Amyloidosis
0.000 0.269 0.731
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.269 0.731
L42 Pityriasis rosea
0.000 0.270 0.730
G20-G26 Extrapyramidal and movement disorders
0.730 0.270 0.000
I21.4 Acute subendocardial myocardial infarction
0.000 0.270 0.730
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.271 0.729
G20 Parkinson's disease
0.729 0.271 0.000
E14.4 With neurological complications
0.000 0.272 0.728
E40-E46 Malnutrition
0.000 0.278 0.722
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.279 0.721
E03.8 Other specified hypothyroidism
0.000 0.282 0.718
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.000 0.283 0.717
L40.3 Pustulosis palmaris et plantaris
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
L40.1 Generalised pustular psoriasis
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.1 Congenital hypothyroidism without goitre
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
E78.6 Lipoprotein deficiency
0.000 0.286 0.714
E78.3 Hyperchylomicronaemia
0.000 0.286 0.714
I24.8 Other forms of acute ischaemic heart disease
0.000 0.287 0.713
E84 Cystic fibrosis
0.000 0.288 0.712
E79 Disorders of purine and pyrimidine metabolism
0.000 0.288 0.712
E77 Disorders of glycoprotein metabolism
0.000 0.288 0.712
E76 Disorders of glycosaminoglycan metabolism
0.000 0.288 0.712
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.288 0.712
E72 Other disorders of amino-acid metabolism
0.000 0.288 0.712
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.288 0.712
E70 Disorders of aromatic amino-acid metabolism
0.000 0.288 0.712
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.288 0.712
E14.8 With unspecified complications
0.000 0.288 0.712
E14.7 With multiple complications
0.000 0.288 0.712
E14.6 With other specified complications
0.000 0.288 0.712
E14.5 With peripheral circulatory complications
0.000 0.288 0.712
E14.2 Withrenal complications
0.000 0.288 0.712
E14.1 With ketoacidosis
0.000 0.288 0.712
E14.0 With coma
0.000 0.288 0.712
G36 Other acute disseminated demyelination
0.711 0.289 0.000
G30-G32 Other degenerative diseases of the nervous system
0.710 0.290 0.000
L43.8 Other lichen planus
0.000 0.293 0.707
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.294 0.706
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.296 0.704
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.298 0.702
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.299 0.701
E05.5 Thyroid crisis or storm
0.000 0.300 0.700
E05.4 Thyrotoxicosis factitia
0.000 0.300 0.700
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.300 0.700
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.300 0.700
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.307 0.693
E07 Other disorders of thyroid
0.000 0.307 0.693
E78.5 Hyperlipidaemia, unspecified
0.000 0.311 0.689
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.684 0.316 0.000
E23 Hypofunction and other disorders of pituitary gland
0.000 0.317 0.683
E11.7 With multiple complications
0.000 0.318 0.682
E11.6 With other specified complications
0.000 0.320 0.680
G31.9 Degenerative disease of nervous system, unspecified
0.675 0.325 0.000
E05.8 Other thyrotoxicosis
0.000 0.326 0.674
L44 Other papulosquamous disorders
0.000 0.328 0.672
L41 Parapsoriasis
0.000 0.328 0.672
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.328 0.672
E24 Cushing's syndrome
0.000 0.329 0.671
E11.2 With renal complications
0.000 0.331 0.669
G37.5 Concentric sclerosis [Balo]
0.667 0.333 0.000
G37.4 Subacute necrotising myelitis
0.667 0.333 0.000
G37.2 Central pontine myelinolysis
0.667 0.333 0.000
G37.1 Central demyelination of corpus callosum
0.667 0.333 0.000
G37.0 Diffuse sclerosis
0.667 0.333 0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.335 0.665
L43.3 Subacute (active) lichen planus
0.000 0.339 0.661
L43.2 Lichenoid drug reaction
0.000 0.339 0.661
L43.1 Bullous lichen planus
0.000 0.339 0.661
L43.0 Hypertrophic lichen planus
0.000 0.339 0.661
I20.0 Unstable angina
0.000 0.339 0.661
I22.8 Subsequent myocardial infarction of other sites
0.000 0.342 0.658
E78.1 Pure hyperglyceridaemia
0.000 0.342 0.658
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.343 0.657
E28 Ovarian dysfunction
0.000 0.344 0.656
E89.3 Postprocedural hypopituitarism
0.000 0.345 0.655
G00-G09 Inflammatory diseases of the central nervous system
0.652 0.348 0.000
I23.8 Other current complications following acute myocardial infarction
0.000 0.356 0.644
E11.8 With unspecified complications
0.000 0.357 0.643
I20.1 Angina pectoris with documented spasm
0.000 0.362 0.638
E73 Lactose intolerance
0.000 0.365 0.635
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.375 0.625
E22 Hyperfunction of pituitary gland
0.000 0.378 0.622
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.378 0.622
E13.8 With unspecified complications
0.000 0.388 0.612
E13.7 With multiple complications
0.000 0.388 0.612
E13.6 With other specified complications
0.000 0.388 0.612
E13.5 With peripheral circulatory complications
0.000 0.388 0.612
E13.4 With neurological complications
0.000 0.388 0.612
E13.3 With ophthalmic complications
0.000 0.388 0.612
E13.2 With renal complications
0.000 0.388 0.612
E13.1 With ketoacidosis
0.000 0.388 0.612
E13.0 With coma
0.000 0.388 0.612
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.388 0.612
I24.1 Dressler's syndrome
0.000 0.403 0.596
E06 Thyroiditis
0.000 0.407 0.593
E28.2 Polycystic ovarian syndrome
0.000 0.410 0.590
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.413 0.587
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.413 0.587
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.413 0.587
E74.2 Disorders of galactose metabolism
0.000 0.413 0.587
E74.1 Disorders of fructose metabolism
0.000 0.413 0.587
E74.0 Glycogen storage disease
0.000 0.413 0.587
E24.9 Cushing's syndrome, unspecified
0.000 0.421 0.579
I25.4 Coronary artery aneurysm
0.000 0.426 0.574
E29 Testicular dysfunction
0.000 0.427 0.573
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.427 0.572
E32 Diseases of thymus
0.000 0.427 0.572
E31 Polyglandular dysfunction
0.000 0.427 0.572
E30 Disorders of puberty, not elsewhere classified
0.000 0.427 0.572
E25 Adrenogenital disorders
0.000 0.427 0.572
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.572 0.428 0.000
G31.2 Degeneration of nervous system due to alcohol
0.569 0.431 0.000
E85.9 Amyloidosis, unspecified
0.000 0.431 0.569
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.432 0.568
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.432 0.568
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.432 0.568
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.432 0.568
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.432 0.568
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.432 0.568
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.432 0.568
E23.2 Diabetes insipidus
0.000 0.441 0.559
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.441 0.559
E16 Other disorders of pancreatic internal secretion
0.000 0.443 0.557
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.444 0.556
M06 Other rheumatoid arthritis
0.000 0.444 0.556
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.554 0.446 0.000
E26 Hyperaldosteronism
0.000 0.449 0.551
E23.7 Disorder of pituitary gland, unspecified
0.000 0.451 0.549
E85.4 Organ-limited amyloidosis
0.000 0.453 0.547
G30 Alzheimer's disease
0.546 0.454 0.000
E89.2 Postprocedural hypoparathyroidism
0.000 0.455 0.545
G00 Bacterial meningitis, not elsewhere classified
0.545 0.455 0.000
E23.6 Other disorders of pituitary gland
0.000 0.462 0.538
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.468 0.532
E15 Nondiabetic hypoglycaemic coma
0.000 0.468 0.532
G36.0 Neuromyelitis optica [Devic]
0.530 0.470 0.000
G03 Meningitis due to other and unspecified causes
0.530 0.470 0.000
E11.5 With peripheral circulatory complications
0.000 0.470 0.530
E83 Disorders of mineral metabolism
0.315 0.472 0.213
E85.8 Other amyloidosis
0.000 0.476 0.524
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.476 0.524
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.476 0.524
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.476 0.524
G23 Other degenerative diseases of basal ganglia
0.524 0.476 0.000
G21 Secondary Parkinsonism
0.524 0.476 0.000
G26 Extrapyramidal and movement disorders in diseases classified elsewhere
0.524 0.476 0.000
G22 Parkinsonism in diseases classified elsewhere
0.524 0.476 0.000
E46 Unspecified protein-energy malnutrition
0.000 0.477 0.523
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.477 0.523
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.477 0.523
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.477 0.523
E89.5 Postprocedural testicular hypofunction
0.000 0.477 0.523
E89.1 Postprocedural hypoinsulinaemia
0.000 0.477 0.523
G06 Intracranial and intraspinal abscess and granuloma
0.522 0.478 0.000
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.482 0.518
E45 Retarded development following protein-energy malnutrition
0.000 0.482 0.518
E43 Unspecified severe protein-energy malnutrition
0.000 0.482 0.518
E42 Marasmic kwashiorkor
0.000 0.482 0.518
E41 Nutritional marasmus
0.000 0.482 0.518
E40 Kwashiorkor
0.000 0.482 0.518
E50-E64 Other nutritional deficiencies
0.000 0.482 0.518
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
G80-G83 Cerebral palsy and other paralytic syndromes
0.514 0.486 0.000
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E89.4 Postprocedural ovarian failure
0.000 0.486 0.514
G32 Other degenerative disorders of nervous system in diseases classified elsewhere
0.512 0.488 0.000
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.489 0.511
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.489 0.511
E70.3 Albinism
0.000 0.489 0.511
E70.2 Disorders of tyrosine metabolism
0.000 0.489 0.511
E70.1 Other hyperphenylalaninaemias
0.000 0.489 0.511
E70.0 Classical phenylketonuria
0.000 0.489 0.511
E71.3 Disorders of fatty-acid metabolism
0.000 0.489 0.511
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.489 0.511
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.489 0.511
E71.0 Maple-syrup-urine disease
0.000 0.489 0.511
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.489 0.511
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.489 0.511
E72.5 Disorders of glycine metabolism
0.000 0.489 0.511
E72.4 Disorders of ornithine metabolism
0.000 0.489 0.511
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.489 0.511
E72.2 Disorders of urea cycle metabolism
0.000 0.489 0.511
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.489 0.511
E72.0 Disorders of amino-acid transport
0.000 0.489 0.511
E75.6 Lipid storage disorder, unspecified
0.000 0.489 0.511
E75.5 Other lipid storage disorders
0.000 0.489 0.511
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.489 0.511
E75.3 Sphingolipidosis, unspecified
0.000 0.489 0.511
E75.2 Other sphingolipidosis
0.000 0.489 0.511
E75.1 Other gangliosidosis
0.000 0.489 0.511
E75.0 GM2 gangliosidosis
0.000 0.489 0.511
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.489 0.511
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.489 0.511
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.489 0.511
E76.2 Other mucopolysaccharidoses
0.000 0.489 0.511
E76.1 Mucopolysaccharidosis, type II
0.000 0.489 0.511
E76.0 Mucopolysaccharidosis, type I
0.000 0.489 0.511
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.489 0.511
E77.8 Other disorders of glycoprotein metabolism
0.000 0.489 0.511
E77.1 Defects in glycoprotein degradation
0.000 0.489 0.511
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.489 0.511
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.489 0.511
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.489 0.511
E79.1 Lesch-Nyhan syndrome
0.000 0.489 0.511
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.489 0.511
E84.9 Cystic fibrosis, unspecified
0.000 0.489 0.511
E84.8 Cystic fibrosis with other manifestations
0.000 0.489 0.511
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.489 0.511
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.489 0.511
G36.9 Acute disseminated demyelination, unspecified
0.510 0.490 0.000
G36.8 Other specified acute disseminated demyelination
0.510 0.490 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.510 0.490 0.000
G09 Sequelae of inflammatory diseases of central nervous system
0.506 0.494 0.000
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.498 0.502
G25 Other extrapyramidal and movement disorders
0.499 0.501 0.000
E07.1 Dyshormogenetic goitre
0.000 0.503 0.497
E07.0 Hypersecretion of calcitonin
0.000 0.503 0.497
E07.9 Disorder of thyroid, unspecified
0.000 0.504 0.496
G08 Intracranial and intraspinal phlebitis and thrombophlebitis
0.493 0.507 0.000
G31.1 Senile degeneration of brain, not elsewhere classified
0.490 0.510 0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.510 0.490
E23.1 Drug-induced hypopituitarism
0.000 0.510 0.490
E34 Other endocrine disorders
0.000 0.516 0.484
E21.3 Hyperparathyroidism, unspecified
0.000 0.517 0.483
L41.9 Parapsoriasis, unspecified
0.000 0.518 0.482
L41.8 Other parapsoriasis
0.000 0.518 0.482
L41.5 Retiform parapsoriasis
0.000 0.518 0.482
L41.4 Large plaque parapsoriasis
0.000 0.518 0.482
L41.3 Small plaque parapsoriasis
0.000 0.518 0.482
L41.2 Lymphomatoid papulosis
0.000 0.518 0.482
L41.1 Pityriasis lichenoides chronica
0.000 0.518 0.482
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.518 0.482
L44.9 Papulosquamous disorder, unspecified
0.000 0.518 0.482
L44.8 Other specified papulosquamous disorders
0.000 0.518 0.482
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.518 0.482
L44.3 Lichen ruber moniliformis
0.000 0.518 0.482
L44.2 Lichen striatus
0.000 0.518 0.482
L44.1 Lichen nitidus
0.000 0.518 0.482
L44.0 Pityriasis rubra pilaris
0.000 0.518 0.482
E24.8 Other Cushing's syndrome
0.000 0.519 0.481
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.519 0.481
E24.3 Ectopic ACTH syndrome
0.000 0.519 0.481
E24.2 Drug-induced Cushing's syndrome
0.000 0.519 0.481
E24.1 Nelson's syndrome
0.000 0.519 0.481
E24.0 Pituitary-dependent Cushing's disease
0.000 0.519 0.481
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.520 0.480
G05 Encephalitis, myelitis and encephalomyelitis in diseases classified elsewhere
0.479 0.521 0.000
M06.3 Rheumatoid nodule
0.000 0.522 0.478
E07.8 Other specified disorders of thyroid
0.000 0.525 0.475
E28.9 Ovarian dysfunction, unspecified
0.000 0.529 0.471
E28.8 Other ovarian dysfunction
0.000 0.529 0.471
E28.1 Androgen excess
0.000 0.529 0.471
E28.0 Oestrogen excess
0.000 0.529 0.471
E88 Other metabolic disorders
0.000 0.530 0.470
G07 Intracranial and intraspinal abscess and granuloma in diseases classified elsewhere
0.467 0.532 0.000
G00.9 Bacterial meningitis, unspecified
0.467 0.533 0.000
G10 Huntington's disease
0.464 0.536 0.000
E85.3 Secondary systemic amyloidosis
0.000 0.537 0.463
G04 Encephalitis, myelitis and encephalomyelitis
0.457 0.543 0.000
E73.8 Other lactose intolerance
0.000 0.545 0.455
E73.1 Secondary lactase deficiency
0.000 0.545 0.455
E73.0 Congenital lactase deficiency
0.000 0.545 0.455
G11 Hereditary ataxia
0.452 0.548 0.000
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.552 0.448
E21.4 Other specified disorders of parathyroid gland
0.000 0.552 0.448
E21.2 Other hyperparathyroidism
0.000 0.552 0.448
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.554 0.446
E22.8 Other hyperfunction of pituitary gland
0.000 0.554 0.446
E20 Hypoparathyroidism
0.001 0.555 0.445
G31.0 Circumscribed brain atrophy
0.445 0.555 0.000
G03.9 Meningitis, unspecified
0.443 0.557 0.000
G24 Dystonia
0.436 0.564 0.000
E21.0 Primary hyperparathyroidism
0.000 0.565 0.435
E23.0 Hypopituitarism
0.000 0.566 0.434
E61 Deficiency of other nutrient elements
0.000 0.572 0.427
E22.1 Hyperprolactinaemia
0.000 0.573 0.427
E06.5 Other chronic thyroiditis
0.000 0.575 0.425
E06.4 Drug-induced thyroiditis
0.000 0.575 0.425
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.575 0.425
E06.1 Subacute thyroiditis
0.000 0.575 0.425
E06.0 Acute thyroiditis
0.000 0.575 0.425
G30.8 Other Alzheimer's disease
0.417 0.582 0.000
E16.2 Hypoglycaemia, unspecified
0.000 0.583 0.417
G02 Meningitis in other infectious and parasitic diseases classified elsewhere
0.412 0.587 0.000
G82 Paraplegia and tetraplegia
0.412 0.588 0.000
E29.1 Testicular hypofunction
0.000 0.588 0.412
E29.9 Testicular dysfunction, unspecified
0.000 0.589 0.411
E29.8 Other testicular dysfunction
0.000 0.589 0.411
E29.0 Testicular hyperfunction
0.000 0.589 0.411
G06.0 Intracranial abscess and granuloma
0.411 0.589 0.000
E25.9 Adrenogenital disorder, unspecified
0.000 0.589 0.410
E25.8 Other adrenogenital disorders
0.000 0.589 0.410
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.589 0.410
E30.9 Disorder of puberty, unspecified
0.000 0.589 0.410
E30.8 Other disorders of puberty
0.000 0.589 0.410
E30.1 Precocious puberty
0.000 0.589 0.410
E30.0 Delayed puberty
0.000 0.589 0.410
E31.9 Polyglandular dysfunction, unspecified
0.000 0.589 0.410
E31.8 Other polyglandular dysfunction
0.000 0.589 0.410
E31.1 Polyglandular hyperfunction
0.000 0.589 0.410
E31.0 Autoimmune polyglandular failure
0.000 0.589 0.410
E32.9 Disease of thymus, unspecified
0.000 0.589 0.410
E32.8 Other diseases of thymus
0.000 0.589 0.410
E32.1 Abscess of thymus
0.000 0.589 0.410
E32.0 Persistent hyperplasia of thymus
0.000 0.589 0.410
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.589 0.410
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.589 0.410
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.589 0.410
G13 Systemic atrophies primarily affecting central nervous system in diseases classified elsewhere
0.410 0.590 0.000
G14 Postpolio syndrome
0.410 0.590 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.592 0.408
M06.34 Rheumatoid nodule (Hand)
0.000 0.595 0.405
G82.1 Spastic paraplegia
0.403 0.597 0.000
G30.0 Alzheimer's disease with early onset
0.402 0.597 0.000
G06.1 Intraspinal abscess and granuloma
0.402 0.598 0.000
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.599 0.400
E80.5 Crigler-Najjar syndrome
0.000 0.599 0.400
E80.3 Defects of catalase and peroxydase
0.000 0.599 0.400
E80.2 Other porphyria
0.000 0.599 0.400
E80.1 Porphyria cutanea tarda
0.000 0.599 0.400
E80.0 Hereditary erythropoietic porphyria
0.000 0.599 0.400
E22.0 Acromegaly and pituitary gigantism
0.000 0.599 0.400
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.600 0.400
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.600 0.400
E16.4 Abnormal secretion of gastrin
0.000 0.600 0.400
E16.3 Increased secretion of glucagon
0.000 0.600 0.400
E16.1 Other hypoglycaemia
0.000 0.600 0.400
E80.6 Other disorders of bilirubin metabolism
0.000 0.600 0.399
M06.8 Other specified rheumatoid arthritis
0.000 0.601 0.398
M06.2 Rheumatoid bursitis
0.000 0.601 0.398
M06.1 Adult-onset Still's disease
0.000 0.601 0.398
E26.9 Hyperaldosteronism, unspecified
0.000 0.605 0.395
E26.8 Other hyperaldosteronism
0.000 0.605 0.395
E26.1 Secondary hyperaldosteronism
0.000 0.605 0.395
M06.4 Inflammatory polyarthropathy
0.000 0.606 0.394
G30.9 Alzheimer's disease, unspecified
0.394 0.606 0.000
I20.8 Other forms of angina pectoris
0.000 0.607 0.393
E06.9 Thyroiditis, unspecified
0.000 0.608 0.392
G00.1 Pneumococcal meningitis
0.392 0.608 0.000
G30.1 Alzheimer's disease with late onset
0.391 0.608 0.000
G00.8 Other bacterial meningitis
0.391 0.609 0.000
G00.3 Staphylococcal meningitis
0.391 0.609 0.000
G00.2 Streptococcal meningitis
0.391 0.609 0.000
G00.0 Haemophilus meningitis
0.391 0.609 0.000
G01 Meningitis in bacterial diseases classified elsewhere
0.389 0.610 0.000
G80 Infantile cerebral palsy
0.385 0.615 0.000
G03.8 Meningitis due to other specified causes
0.380 0.620 0.000
G03.2 Benign recurrent meningitis [Mollaret]
0.380 0.620 0.000
G03.1 Chronic meningitis
0.380 0.620 0.000
G03.0 Nonpyogenic meningitis
0.380 0.620 0.000
E83.9 Disorder of mineral metabolism, unspecified
0.226 0.621 0.153
E83.8 Other disorders of mineral metabolism
0.226 0.621 0.153
E83.2 Disorders of zinc metabolism
0.226 0.621 0.153
E83.0 Disorders of copper metabolism
0.226 0.621 0.153
K90 Intestinal malabsorption
0.000 0.622 0.378
E73.9 Lactose intolerance, unspecified
0.000 0.622 0.378
G21.9 Secondary Parkinsonism, unspecified
0.375 0.624 0.000
G21.8 Other secondary Parkinsonism
0.375 0.624 0.000
G21.4 Vascular parkinsonism
0.375 0.624 0.000
G21.3 Postencephalitic Parkinsonism
0.375 0.624 0.000
G21.2 Secondary Parkinsonism due to other external agents
0.375 0.624 0.000
G21.1 Other drug-induced secondary Parkinsonism
0.375 0.624 0.000
G21.0 Malignant neuroleptic syndrome
0.375 0.624 0.000
G23.9 Degenerative disease of basal ganglia, unspecified
0.375 0.624 0.000
G23.8 Other specified degenerative diseases of basal ganglia
0.375 0.624 0.000
G23.3 Multiple system atrophy, cerebellar type
0.375 0.624 0.000
G23.2 Striatonigral degeneration
0.375 0.624 0.000
G23.1 Progressive supranuclear ophthalmoplegia [Steele-Richardson-Olszewski]
0.375 0.624 0.000
G23.0 Hallervorden-Spatz disease
0.375 0.624 0.000
E26.0 Primary hyperaldosteronism
0.000 0.626 0.374
G83 Other paralytic syndromes
0.374 0.626 0.000
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.627 0.373
E44.1 Mild protein-energy malnutrition
0.000 0.628 0.371
E44.0 Moderate protein-energy malnutrition
0.000 0.628 0.371
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.628 0.371
E63 Other nutritional deficiencies
0.000 0.628 0.371
E56 Other vitamin deficiencies
0.000 0.628 0.371
E50 Vitamin A deficiency
0.000 0.628 0.371
E60 Dietary zinc deficiency
0.000 0.628 0.371
E59 Dietary selenium deficiency
0.000 0.628 0.371
E58 Dietary calcium deficiency
0.000 0.628 0.371
E54 Ascorbic acid deficiency
0.000 0.628 0.371
E52 Niacin deficiency [pellagra]
0.000 0.628 0.371
G06.2 Extradural and subdural abscess, unspecified
0.370 0.630 0.000
G32.8 Other specified degenerative disorders of nervous system in diseases classified elsewhere
0.370 0.630 0.000
E28.3 Primary ovarian failure
0.000 0.630 0.370
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.630 0.370
G25.0 Essential tremor
0.368 0.632 0.000
G32.0 Subacute combined degeneration of spinal cord in diseases classified elsewhere
0.367 0.633 0.000
E61.1 Iron deficiency
0.000 0.635 0.365
G25.9 Extrapyramidal and movement disorder, unspecified
0.365 0.635 0.000
G11.4 Hereditary spastic paraplegia
0.364 0.636 0.000
E51 Thiamine deficiency
0.000 0.639 0.361
E65-E68 Obesity and other hyperalimentation
0.000 0.641 0.359
G25.6 Drug-induced tics and other tics of organic origin
0.358 0.642 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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