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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs10744777
log Bayes Factor = 24.8672
Chromosome 12   position 112,233,018  (GRCh37) Explore rs10744777 on Ensembl!
Variant rs10744777 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
I21 Acute myocardial infarction
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.001 0.999
Z95.5 Presence of coronary angioplasty implant and graft
0.000 0.004 0.996
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.006 0.994
Z95 Presence of cardiac and vascular implants and grafts
0.000 0.007 0.993
C77.3 Axillary and upper limb lymph nodes
0.979 0.021 0.000
Z95.4 Presence of other heart-valve replacement
0.000 0.037 0.963
I22 Subsequent myocardial infarction
0.000 0.038 0.962
Z95.2 Presence of prosthetic heart valve
0.000 0.059 0.941
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.091 0.909
I21.9 Acute myocardial infarction, unspecified
0.000 0.093 0.907
Z95.3 Presence of xenogenic heart valve
0.000 0.098 0.902
Z95.8 Presence of other cardiac and vascular implants and grafts
0.000 0.115 0.885
I25.5 Ischaemic cardiomyopathy
0.000 0.123 0.877
Chapter IX Diseases of the circulatory system
0.000 0.139 0.861
I30-I52 Other forms of heart disease
0.000 0.142 0.858
I49.9 Cardiac arrhythmia, unspecified
0.000 0.150 0.850
I49 Other cardiac arrhythmias
0.000 0.152 0.848
I42 Cardiomyopathy
0.000 0.157 0.843
Z95.0 Presence of cardiac pacemaker
0.000 0.173 0.827
I42.0 Dilated cardiomyopathy
0.000 0.200 0.800
I22.8 Subsequent myocardial infarction of other sites
0.000 0.202 0.798
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.205 0.795
I23 Certain current complications following acute myocardial infarction
0.000 0.208 0.792
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.221 0.779
I42.9 Cardiomyopathy, unspecified
0.000 0.222 0.778
I21.4 Acute subendocardial myocardial infarction
0.000 0.226 0.774
E03 Other hypothyroidism
0.000 0.230 0.770
I95-I99 Other and unspecified disorders of the circulatory system
0.000 0.230 0.770
I36 Nonrheumatic tricuspid valve disorders
0.000 0.236 0.764
I50 Heart failure
0.000 0.250 0.750
I42.1 Obstructive hypertrophic cardiomyopathy
0.000 0.251 0.749
I25.4 Coronary artery aneurysm
0.000 0.263 0.737
Z95.9 Presence of cardiac and vascular implant and graft, unspecified
0.000 0.269 0.731
I37 Pulmonary valve disorders
0.000 0.279 0.721
I38 Endocarditis, valve unspecified
0.000 0.281 0.719
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
I99 Other and unspecified disorders of circulatory system
0.000 0.286 0.714
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.000 0.292 0.708
I50.1 Left ventricular failure
0.000 0.296 0.704
I49.3 Ventricular premature depolarisation
0.000 0.298 0.702
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.299 0.701
I36.1 Nonrheumatic tricuspid (valve) insufficiency
0.000 0.303 0.697
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.304 0.696
I42.6 Alcoholic cardiomyopathy
0.000 0.319 0.681
I26 Pulmonary embolism
0.000 0.328 0.672
I10-I15 Hypertensive diseases
0.000 0.329 0.671
I25.2 Old myocardial infarction
0.000 0.330 0.670
I31 Other diseases of pericardium
0.000 0.334 0.666
I26.9 Pulmonary embolism without mention of acute cor pulmonale
0.000 0.346 0.654
I23.8 Other current complications following acute myocardial infarction
0.000 0.356 0.644
I49.0 Ventricular fibrillation and flutter
0.000 0.358 0.642
I10 Essential (primary) hypertension
0.000 0.361 0.639
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.365 0.635
I25.3 Aneurysm of heart
0.000 0.367 0.633
I37.1 Pulmonary valve insufficiency
0.000 0.372 0.628
E03.8 Other specified hypothyroidism
0.000 0.372 0.628
I35 Nonrheumatic aortic valve disorders
0.000 0.373 0.627
I52 Other heart disorders in diseases classified elsewhere
0.000 0.385 0.615
I48 Atrial fibrillation and flutter
0.000 0.385 0.615
I41 Myocarditis in diseases classified elsewhere
0.000 0.385 0.615
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.000 0.385 0.615
I32 Pericarditis in diseases classified elsewhere
0.000 0.385 0.615
I97.1 Other functional disturbances following cardiac surgery
0.000 0.389 0.611
I43 Cardiomyopathy in diseases classified elsewhere
0.000 0.391 0.609
I40 Acute myocarditis
0.000 0.392 0.608
I49.2 Junctional premature depolarisation
0.000 0.392 0.608
I42.5 Other restrictive cardiomyopathy
0.000 0.396 0.604
I42.4 Endocardial fibroelastosis
0.000 0.396 0.604
I42.3 Endomyocardial (eosinophilic) disease
0.000 0.396 0.604
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.397 0.603
I49.5 Sick sinus syndrome
0.000 0.397 0.603
E00-E07 Disorders of thyroid gland
0.000 0.402 0.598
I35.2 Aortic (valve) stenosis with insufficiency
0.000 0.407 0.593
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.407 0.593
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.419 0.581
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.432 0.568
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.432 0.568
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.432 0.568
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.432 0.568
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.432 0.568
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.432 0.568
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.432 0.568
I97.2 Postmastectomy lymphoedema syndrome
0.000 0.440 0.560
E03.5 Myxoedema coma
0.000 0.448 0.552
E03.4 Atrophy of thyroid (acquired)
0.000 0.448 0.552
E03.3 Postinfectious hypothyroidism
0.000 0.448 0.552
E10 Insulin-dependent diabetes mellitus
0.000 0.448 0.552
E10.3 With ophthalmic complications
0.000 0.448 0.552
I31.0 Chronic adhesive pericarditis
0.000 0.450 0.550
I00-I02 Acute rheumatic fever
0.000 0.451 0.549
I97.8 Other postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.452 0.548
I36.9 Nonrheumatic tricuspid valve disorder, unspecified
0.000 0.452 0.548
I36.8 Other nonrheumatic tricuspid valve disorders
0.000 0.452 0.548
I36.2 Nonrheumatic tricuspid (valve) stenosis with insufficiency
0.000 0.452 0.548
I36.0 Nonrheumatic tricuspid (valve) stenosis
0.000 0.452 0.548
I73 Other peripheral vascular diseases
0.000 0.453 0.547
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.466 0.534
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.467 0.533
E03.1 Congenital hypothyroidism without goitre
0.000 0.467 0.533
I31.1 Chronic constrictive pericarditis
0.000 0.471 0.529
E10-E14 Diabetes mellitus
0.000 0.476 0.524
I50.0 Congestive heart failure
0.000 0.479 0.521
I37.9 Pulmonary valve disorder, unspecified
0.000 0.483 0.517
I37.8 Other pulmonary valve disorders
0.000 0.483 0.517
I37.2 Pulmonary valve stenosis with insufficiency
0.000 0.483 0.517
E20-E35 Disorders of other endocrine glands
0.000 0.485 0.515
I73.9 Peripheral vascular disease, unspecified
0.000 0.489 0.511
E10.9 Without complications
0.000 0.490 0.510
I98 Other disorders of circulatory system in diseases classified elsewhere
0.000 0.493 0.507
I37.0 Pulmonary valve stenosis
0.000 0.494 0.506
I45 Other conduction disorders
0.000 0.495 0.505
I97.9 Postprocedural disorder of circulatory system, unspecified
0.000 0.497 0.503
I97.0 Postcardiotomy syndrome
0.000 0.497 0.503
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.499 0.501
I51 Complications and ill-defined descriptions of heart disease
0.000 0.502 0.498
Z95.1 Presence of aortocoronary bypass graft
0.000 0.502 0.498
I20 Angina pectoris
0.000 0.503 0.497
I44 Atrioventricular and left bundle-branch block
0.000 0.503 0.497
I42.7 Cardiomyopathy due to drugs and other external agents
0.000 0.508 0.492
I78 Diseases of capillaries
0.000 0.509 0.491
I49.1 Atrial premature depolarisation
0.000 0.509 0.491
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.509 0.491
E10.5 With peripheral circulatory complications
0.000 0.513 0.487
E06 Thyroiditis
0.000 0.514 0.486
I28 Other diseases of pulmonary vessels
0.000 0.518 0.482
I13 Hypertensive heart and renal disease
0.000 0.519 0.481
I15 Secondary hypertension
0.000 0.519 0.481
I31.8 Other specified diseases of pericardium
0.000 0.523 0.477
I31.2 Haemopericardium, not elsewhere classified
0.000 0.523 0.477
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.524 0.476
E23 Hypofunction and other disorders of pituitary gland
0.000 0.525 0.475
I33 Acute and subacute endocarditis
0.000 0.529 0.471
I42.2 Other hypertrophic cardiomyopathy
0.000 0.530 0.470
I42.8 Other cardiomyopathies
0.000 0.532 0.468
I51.7 Cardiomegaly
0.000 0.538 0.462
E27 Other disorders of adrenal gland
0.000 0.538 0.462
I44.6 Other and unspecified fascicular block
0.000 0.539 0.461
I40.9 Acute myocarditis, unspecified
0.000 0.539 0.461
E10.2 With renal complications
0.000 0.541 0.459
I30 Acute pericarditis
0.000 0.545 0.455
I31.3 Pericardial effusion (noninflammatory)
0.000 0.547 0.453
E07 Other disorders of thyroid
0.000 0.549 0.451
I45.9 Conduction disorder, unspecified
0.000 0.550 0.450
E10.0 With coma
0.000 0.551 0.448
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.555 0.445
I35.0 Aortic (valve) stenosis
0.000 0.556 0.444
I45.4 Nonspecific intraventricular block
0.000 0.556 0.444
I32.8 Pericarditis in other diseases classified elsewhere
0.000 0.559 0.441
I32.1 Pericarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.559 0.441
I32.0 Pericarditis in bacterial diseases classified elsewhere
0.000 0.559 0.441
I39.8 Endocarditis, valve unspecified, in diseases classified elsewhere
0.000 0.559 0.441
I39.4 Multiple valve disorders in diseases classified elsewhere
0.000 0.559 0.441
I39.3 Pulmonary valve disorders in diseases classified elsewhere
0.000 0.559 0.441
I39.2 Tricuspid valve disorders in diseases classified elsewhere
0.000 0.559 0.441
I39.1 Aortic valve disorders in diseases classified elsewhere
0.000 0.559 0.441
I39.0 Mitral valve disorders in diseases classified elsewhere
0.000 0.559 0.441
I41.8 Myocarditis in other diseases classified elsewhere
0.000 0.559 0.441
I41.2 Myocarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.559 0.441
I41.1 Myocarditis in viral diseases classified elsewhere
0.000 0.559 0.441
I41.0 Myocarditis in bacterial diseases classified elsewhere
0.000 0.559 0.441
I48.9 Atrial fibrillation and atrial flutter, unspecified
0.000 0.559 0.441
I48.4 Atypical atrial flutter
0.000 0.559 0.441
I48.3 Typical atrial flutter
0.000 0.559 0.441
I48.2 Chronic atrial fibrillation
0.000 0.559 0.441
I48.1 Persistent atrial fibrillation
0.000 0.559 0.441
I48.0 Paroxysmal atrial fibrillation
0.000 0.559 0.441
I52.8 Other heart disorders in other diseases classified elsewhere
0.000 0.559 0.441
I52.1 Other heart disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.559 0.441
I52.0 Other heart disorders in bacterial diseases classified elsewhere
0.000 0.559 0.441
E23.0 Hypopituitarism
0.000 0.559 0.441
I47 Paroxysmal tachycardia
0.000 0.563 0.437
I43.8 Cardiomyopathy in other diseases classified elsewhere
0.000 0.563 0.436
I43.2 Cardiomyopathy in nutritional diseases
0.000 0.563 0.436
I43.0 Cardiomyopathy in infectious and parasitic diseases classified elsewhere
0.000 0.563 0.436
I40.8 Other acute myocarditis
0.000 0.564 0.436
I40.1 Isolated myocarditis
0.000 0.564 0.436
I73.8 Other specified peripheral vascular diseases
0.000 0.566 0.434
E10.8 With unspecified complications
0.000 0.567 0.433
I43.1 Cardiomyopathy in metabolic diseases
0.000 0.570 0.430
I24 Other acute ischaemic heart diseases
0.000 0.570 0.430
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.571 0.429
E00 Congenital iodine-deficiency syndrome
0.000 0.571 0.429
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.000 0.572 0.428
I78.0 Hereditary haemorrhagic telangiectasia
0.000 0.573 0.427
I50.9 Heart failure, unspecified
0.000 0.574 0.426
I20.8 Other forms of angina pectoris
0.000 0.581 0.419
I77 Other disorders of arteries and arterioles
0.000 0.582 0.418
E28 Ovarian dysfunction
0.000 0.584 0.416
E06.9 Thyroiditis, unspecified
0.000 0.585 0.415
I51.9 Heart disease, unspecified
0.000 0.589 0.411
E10.6 With other specified complications
0.000 0.590 0.410
I15.1 Hypertension secondary to other renal disorders
0.000 0.590 0.410
E20 Hypoparathyroidism
0.000 0.595 0.405
I78.8 Other diseases of capillaries
0.000 0.596 0.404
I45.6 Preexcitation syndrome
0.000 0.599 0.401
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.599 0.401
I40.0 Infective myocarditis
0.000 0.600 0.400
I26.0 Pulmonary embolism with mention of acute cor pulmonale
0.000 0.601 0.399
I05-I09 Chronic rheumatic heart diseases
0.000 0.601 0.399
E27.1 Primary adrenocortical insufficiency
0.000 0.603 0.397
E25 Adrenogenital disorders
0.000 0.606 0.394
I02 Rheumatic chorea
0.000 0.606 0.394
I01 Rheumatic fever with heart involvement
0.000 0.606 0.394
E50-E64 Other nutritional deficiencies
0.000 0.606 0.394
I73.1 Thromboangiitis obliterans [Buerger]
0.000 0.607 0.393
I31.9 Disease of pericardium, unspecified
0.000 0.608 0.392
E23.2 Diabetes insipidus
0.000 0.612 0.388
E26 Hyperaldosteronism
0.000 0.615 0.384
E07.9 Disorder of thyroid, unspecified
0.000 0.616 0.383
E34 Other endocrine disorders
0.000 0.621 0.379
I44.4 Left anterior fascicular block
0.000 0.623 0.377
E12 Malnutrition-related diabetes mellitus
0.000 0.624 0.376
E27.8 Other specified disorders of adrenal gland
0.000 0.627 0.373
I77.6 Arteritis, unspecified
0.000 0.627 0.373
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.000 0.629 0.371
I47.2 Ventricular tachycardia
0.000 0.630 0.370
E21.3 Hyperparathyroidism, unspecified
0.000 0.630 0.370
I45.2 Bifascicular block
0.000 0.630 0.370
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.631 0.369
E30 Disorders of puberty, not elsewhere classified
0.000 0.631 0.369
E27.9 Disorder of adrenal gland, unspecified
0.000 0.633 0.367
E10.4 With neurological complications
0.000 0.633 0.367
E23.6 Other disorders of pituitary gland
0.000 0.635 0.365
I98.8 Other specified disorders of circulatory system in diseases classified elsewhere
0.000 0.636 0.364
I98.1 Cardiovascular disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.636 0.364
I98.0 Cardiovascular syphilis
0.000 0.636 0.364
I45.8 Other specified conduction disorders
0.000 0.637 0.363
I45.0 Right fascicular block
0.000 0.638 0.362
I51.5 Myocardial degeneration
0.000 0.642 0.357
I51.2 Rupture of papillary muscle, not elsewhere classified
0.000 0.642 0.357
I44.3 Other and unspecified atrioventricular block
0.000 0.643 0.357
I44.5 Left posterior fascicular block
0.000 0.643 0.356
E21.0 Primary hyperparathyroidism
0.000 0.644 0.356
I73.0 Raynaud's syndrome
0.000 0.646 0.354
I35.9 Aortic valve disorder, unspecified
0.000 0.648 0.352
I78.9 Disease of capillaries, unspecified
0.000 0.648 0.352
I79.1 Aortitis in diseases classified elsewhere
0.000 0.648 0.352
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.000 0.648 0.352
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.650 0.350
E06.4 Drug-induced thyroiditis
0.000 0.651 0.348
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.651 0.348
E06.1 Subacute thyroiditis
0.000 0.651 0.348
E06.0 Acute thyroiditis
0.000 0.651 0.348
I28.9 Disease of pulmonary vessels, unspecified
0.000 0.654 0.346
I28.1 Aneurysm of pulmonary artery
0.000 0.654 0.346
I28.0 Arteriovenous fistula of pulmonary vessels
0.000 0.654 0.346
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.655 0.345
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.655 0.345
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.655 0.345
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.655 0.345
I15.8 Other secondary hypertension
0.000 0.655 0.345
I15.0 Renovascular hypertension
0.000 0.655 0.345
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere
0.000 0.656 0.343
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.658 0.342
I98.2 Oesophageal varices in diseases classified elsewhere
0.000 0.658 0.342
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.659 0.341
E23.1 Drug-induced hypopituitarism
0.000 0.659 0.341
E31 Polyglandular dysfunction
0.000 0.660 0.340
E06.5 Other chronic thyroiditis
0.000 0.660 0.340
E28.3 Primary ovarian failure
0.000 0.661 0.339
I33.9 Acute endocarditis, unspecified
0.000 0.662 0.338
E06.3 Autoimmune thyroiditis
0.000 0.663 0.337
E61 Deficiency of other nutrient elements
0.000 0.663 0.337
E21.2 Other hyperparathyroidism
0.000 0.664 0.336
I24.8 Other forms of acute ischaemic heart disease
0.000 0.664 0.336
E32 Diseases of thymus
0.000 0.664 0.335
I77.9 Disorder of arteries and arterioles, unspecified
0.000 0.667 0.333
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.667 0.333
E27.5 Adrenomedullary hyperfunction
0.000 0.669 0.331
E27.0 Other adrenocortical overactivity
0.000 0.669 0.331
I15.2 Hypertension secondary to endocrine disorders
0.000 0.670 0.330
I70 Atherosclerosis
0.000 0.670 0.330
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.671 0.328
I24.1 Dressler's syndrome
0.000 0.673 0.327
E20.9 Hypoparathyroidism, unspecified
0.000 0.673 0.327
I30.8 Other forms of acute pericarditis
0.000 0.673 0.326
I30.0 Acute nonspecific idiopathic pericarditis
0.000 0.673 0.326
E27.2 Addisonian crisis
0.000 0.673 0.326
I51.6 Cardiovascular disease, unspecified
0.000 0.674 0.326
I08 Multiple valve diseases
0.000 0.674 0.326
I00 Rheumatic fever without mention of heart involvement
0.000 0.674 0.326
I30.1 Infective pericarditis
0.000 0.675 0.325
E10.7 With multiple complications
0.000 0.675 0.324
I49.8 Other specified cardiac arrhythmias
0.000 0.676 0.324
I49.4 Other and unspecified premature depolarisation
0.000 0.676 0.324
E22 Hyperfunction of pituitary gland
0.000 0.676 0.324
E07.1 Dyshormogenetic goitre
0.000 0.676 0.324
E07.0 Hypersecretion of calcitonin
0.000 0.676 0.324
I35.8 Other aortic valve disorders
0.000 0.679 0.321
I28.8 Other specified diseases of pulmonary vessels
0.000 0.680 0.320
E21.4 Other specified disorders of parathyroid gland
0.000 0.680 0.319
I35.1 Aortic (valve) insufficiency
0.000 0.681 0.319
I51.4 Myocarditis, unspecified
0.000 0.681 0.319
E13 Other specified diabetes mellitus
0.000 0.684 0.316
I47.9 Paroxysmal tachycardia, unspecified
0.000 0.685 0.315
I77.2 Rupture of artery
0.000 0.687 0.313
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.687 0.313
E28.2 Polycystic ovarian syndrome
0.000 0.690 0.310
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.692 0.308
I12 Hypertensive renal disease
0.000 0.692 0.308
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.692 0.308
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.692 0.308
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.692 0.308
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.692 0.308
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.692 0.308
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.692 0.308
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.692 0.308
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.692 0.308
I20.9 Angina pectoris, unspecified
0.000 0.693 0.307
E34.9 Endocrine disorder, unspecified
0.000 0.694 0.306
E16 Other disorders of pancreatic internal secretion
0.000 0.694 0.306
E10.1 With ketoacidosis
0.000 0.694 0.305
I77.8 Other specified disorders of arteries and arterioles
0.000 0.696 0.304
I44.1 Atrioventricular block, second degree
0.000 0.698 0.302
I77.5 Necrosis of artery
0.000 0.700 0.300
I77.4 Coeliac artery compression syndrome
0.000 0.700 0.300
E28.9 Ovarian dysfunction, unspecified
0.000 0.701 0.299
E28.8 Other ovarian dysfunction
0.000 0.701 0.299
E28.1 Androgen excess
0.000 0.701 0.299
E28.0 Oestrogen excess
0.000 0.701 0.299
I74 Arterial embolism and thrombosis
0.000 0.703 0.297
E26.0 Primary hyperaldosteronism
0.000 0.703 0.297
E53 Deficiency of other B group vitamins
0.000 0.706 0.294
E56 Other vitamin deficiencies
0.000 0.709 0.291
E20.8 Other hypoparathyroidism
0.000 0.709 0.291
E20.1 Pseudohypoparathyroidism
0.000 0.709 0.291
E20.0 Idiopathic hypoparathyroidism
0.000 0.709 0.291
I51.0 Cardiac septal defect, acquired
0.000 0.711 0.289
E40-E46 Malnutrition
0.000 0.712 0.288
E15 Nondiabetic hypoglycaemic coma
0.000 0.712 0.288
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.713 0.287
E61.1 Iron deficiency
0.000 0.714 0.286
I71 Aortic aneurysm and dissection
0.000 0.716 0.284
E25.9 Adrenogenital disorder, unspecified
0.000 0.717 0.283
E25.8 Other adrenogenital disorders
0.000 0.717 0.283
I01.9 Acute rheumatic heart disease, unspecified
0.000 0.717 0.282
I01.8 Other acute rheumatic heart disease
0.000 0.717 0.282
I01.2 Acute rheumatic myocarditis
0.000 0.717 0.282
I01.1 Acute rheumatic endocarditis
0.000 0.717 0.282
I01.0 Acute rheumatic pericarditis
0.000 0.717 0.282
I02.9 Rheumatic chorea without heart involvement
0.000 0.717 0.282
I02.0 Rheumatic chorea with heart involvement
0.000 0.717 0.282
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.717 0.283
E63 Other nutritional deficiencies
0.000 0.717 0.283
E50 Vitamin A deficiency
0.000 0.717 0.283
E60 Dietary zinc deficiency
0.000 0.717 0.283
E59 Dietary selenium deficiency
0.000 0.717 0.283
E58 Dietary calcium deficiency
0.000 0.717 0.283
E52 Niacin deficiency [pellagra]
0.000 0.717 0.283
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.720 0.280
I20.0 Unstable angina
0.000 0.722 0.278
E26.8 Other hyperaldosteronism
0.000 0.724 0.276
E26.1 Secondary hyperaldosteronism
0.000 0.724 0.276
I51.3 Intracardiac thrombosis, not elsewhere classified
0.000 0.724 0.275
I08.1 Disorders of both mitral and tricuspid valves
0.000 0.725 0.275
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.000 0.726 0.274
E24 Cushing's syndrome
0.000 0.727 0.272
E51 Thiamine deficiency
0.000 0.728 0.272
E34.5 Androgen resistance syndrome
0.000 0.728 0.272
E34.4 Constitutional tall stature
0.000 0.728 0.272
E34.3 Short stature, not elsewhere classified
0.000 0.728 0.272
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.728 0.272
E34.1 Other hypersecretion of intestinal hormones
0.000 0.728 0.272
E23.7 Disorder of pituitary gland, unspecified
0.000 0.730 0.270
I06 Rheumatic aortic valve diseases
0.000 0.730 0.270
I08.2 Disorders of both aortic and tricuspid valves
0.000 0.730 0.270
E34.0 Carcinoid syndrome
0.000 0.730 0.270
E12.9 Without complications
0.000 0.730 0.269
E12.8 With unspecified complications
0.000 0.730 0.269
E12.7 With multiple complications
0.000 0.730 0.269
E12.6 With other specified complications
0.000 0.730 0.269
E12.5 With peripheral circulatory complications
0.000 0.730 0.269
E12.4 With neurological complications
0.000 0.730 0.269
E12.3 With ophthalmic complications
0.000 0.730 0.269
E12.2 With renal complications
0.000 0.730 0.269
E12.1 With ketoacidosis
0.000 0.730 0.269
E12.0 With coma
0.000 0.730 0.269
E26.9 Hyperaldosteronism, unspecified
0.000 0.732 0.268
I47.0 Reentry ventricular arrhythmia
0.000 0.733 0.267
E05.9 Thyrotoxicosis, unspecified
0.000 0.733 0.267
E54 Ascorbic acid deficiency
0.000 0.734 0.266
E30.9 Disorder of puberty, unspecified
0.000 0.735 0.265
E30.8 Other disorders of puberty
0.000 0.735 0.265
E30.1 Precocious puberty
0.000 0.735 0.265
E30.0 Delayed puberty
0.000 0.735 0.265
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.735 0.265
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.735 0.265
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.735 0.265
E61.2 Magnesium deficiency
0.000 0.738 0.262
E29 Testicular dysfunction
0.000 0.740 0.260
I46 Cardiac arrest
0.000 0.740 0.259
C90.0 Multiple myeloma
0.259 0.741 0.000
I44.0 Atrioventricular block, first degree
0.000 0.741 0.259
E16.1 Other hypoglycaemia
0.000 0.742 0.258
I44.7 Left bundle-branch block, unspecified
0.000 0.743 0.257
C90 Multiple myeloma and malignant plasma cell neoplasms
0.255 0.745 0.000
E07.8 Other specified disorders of thyroid
0.000 0.746 0.254
E22.1 Hyperprolactinaemia
0.000 0.747 0.253
E05.5 Thyroid crisis or storm
0.000 0.749 0.251
E05.4 Thyrotoxicosis factitia
0.000 0.749 0.251
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.749 0.251
I11 Hypertensive heart disease
0.001 0.749 0.250
I07 Rheumatic tricuspid valve diseases
0.000 0.752 0.248
I77.0 Arteriovenous fistula, acquired
0.000 0.753 0.247
I74.5 Embolism and thrombosis of iliac artery
0.000 0.755 0.245
E31.9 Polyglandular dysfunction, unspecified
0.000 0.756 0.244
E31.8 Other polyglandular dysfunction
0.000 0.756 0.244
E31.1 Polyglandular hyperfunction
0.000 0.756 0.244
I77.3 Arterial fibromuscular dysplasia
0.000 0.756 0.244
I15.9 Seconday hypertension, unspecified
0.001 0.756 0.243
E61.9 Deficiency of nutrient element, unspecified
0.000 0.758 0.242
E61.8 Deficiency of other specified nutrient elements
0.000 0.758 0.242
E61.7 Deficiency of multiple nutrient elements
0.000 0.758 0.242
E61.6 Vanadium deficiency
0.000 0.758 0.242
E61.5 Molybdenum deficiency
0.000 0.758 0.242
E61.4 Chromium deficiency
0.000 0.758 0.242
E61.3 Manganese deficiency
0.000 0.758 0.242
E61.0 Copper deficiency
0.000 0.758 0.242
E32.9 Disease of thymus, unspecified
0.000 0.759 0.241
E32.1 Abscess of thymus
0.000 0.759 0.241
E32.0 Persistent hyperplasia of thymus
0.000 0.759 0.241
I72 Other aneurysm
0.000 0.760 0.240
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.240 0.760 0.000
I70.1 Atherosclerosis of renal artery
0.000 0.761 0.239
I78.1 Naevus, nonneoplastic
0.000 0.763 0.237
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.000 0.763 0.237
E34.8 Other specified endocrine disorders
0.000 0.763 0.237
E16.2 Hypoglycaemia, unspecified
0.000 0.765 0.235
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.000 0.766 0.234
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.768 0.232
E22.8 Other hyperfunction of pituitary gland
0.000 0.768 0.232
I70.9 Generalised and unspecified atherosclerosis
0.000 0.768 0.232
I08.9 Multiple valve disease, unspecified
0.000 0.769 0.231
I09 Other rheumatic heart diseases
0.000 0.770 0.229
E53.9 Vitamin B deficiency, unspecified
0.000 0.772 0.228
C84 Peripheral and cutaneous T-cell lymphomas
0.227 0.773 0.000
C77 Secondary and unspecified malignant neoplasm of lymph nodes
0.227 0.773 0.000
E13.8 With unspecified complications
0.000 0.773 0.226
E13.7 With multiple complications
0.000 0.773 0.226
E13.6 With other specified complications
0.000 0.773 0.226
E13.5 With peripheral circulatory complications
0.000 0.773 0.226
E13.4 With neurological complications
0.000 0.773 0.226
E13.2 With renal complications
0.000 0.773 0.226
E13.1 With ketoacidosis
0.000 0.773 0.226
E13.0 With coma
0.000 0.773 0.226
I70.8 Atherosclerosis of other arteries
0.000 0.775 0.225
I70.0 Atherosclerosis of aorta
0.000 0.777 0.223
C90.2 Plasmacytoma, extramedullary
0.223 0.777 0.000
I74.0 Embolism and thrombosis of abdominal aorta
0.000 0.779 0.221
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.780 0.220
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.780 0.220
E16.4 Abnormal secretion of gastrin
0.000 0.780 0.220
E16.3 Increased secretion of glucagon
0.000 0.780 0.220
E05.8 Other thyrotoxicosis
0.000 0.781 0.219
C77.4 Inguinal and lower limb lymph nodes
0.219 0.781 0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.782 0.218
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.783 0.217
E56.1 Deficiency of vitamin K
0.000 0.783 0.217
E31.0 Autoimmune polyglandular failure
0.000 0.785 0.215
C95 Leukaemia of unspecified cell type
0.214 0.786 0.000
E53.1 Pyridoxine deficiency
0.000 0.789 0.211
E53.0 Riboflavin deficiency
0.000 0.789 0.211
E24.0 Pituitary-dependent Cushing's disease
0.000 0.789 0.210
C50 Malignant neoplasm of breast
0.210 0.790 0.000
C90.1 Plasma cell leukaemia
0.210 0.790 0.000
E56.9 Vitamin deficiency, unspecified
0.000 0.791 0.209
E56.8 Deficiency of other vitamins
0.000 0.791 0.209
E56.0 Deficiency of vitamin E
0.000 0.791 0.209
E55 Vitamin D deficiency
0.000 0.793 0.207
E32.8 Other diseases of thymus
0.000 0.793 0.207
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.793 0.207
E45 Retarded development following protein-energy malnutrition
0.000 0.793 0.207
E43 Unspecified severe protein-energy malnutrition
0.000 0.793 0.207
E42 Marasmic kwashiorkor
0.000 0.793 0.207
E41 Nutritional marasmus
0.000 0.793 0.207
E40 Kwashiorkor
0.000 0.793 0.207
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.000 0.794 0.205
C81 Hodgkin's disease
0.205 0.795 0.000
I74.9 Embolism and thrombosis of unspecified artery
0.000 0.795 0.205
C50-C50 Malignant neoplasm of breast
0.205 0.795 0.000
I71.8 Aortic aneurysm of unspecified site, ruptured
0.000 0.796 0.204
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.000 0.796 0.204
I71.1 Thoracic aortic aneurysm, ruptured
0.000 0.796 0.204
I06.0 Rheumatic aortic stenosis
0.000 0.796 0.204
E53.8 Deficiency of other specified B group vitamins
0.000 0.797 0.203
E50.9 Vitamin A deficiency, unspecified
0.000 0.797 0.203
E50.8 Other manifestations of vitamin A deficiency
0.000 0.797 0.203
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.797 0.203
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.797 0.203
E50.5 Vitamin A deficiency with night blindness
0.000 0.797 0.203
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.797 0.203
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.797 0.203
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.797 0.203

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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