TreeWAS – Variant ID: rs11057841

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
I25 Chronic ischaemic heart disease	1.000	0.000	0.000
E78.0 Pure hypercholesterolaemia	1.000	0.000	0.000
I20.9 Angina pectoris, unspecified	1.000	0.000	0.000
I25.8 Other forms of chronic ischaemic heart disease	1.000	0.000	0.000
I20-I25 Ischaemic heart diseases	1.000	0.000	0.000
I20 Angina pectoris	0.999	0.001	0.000
I25.1 Atherosclerotic heart disease	0.999	0.001	0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias	0.999	0.001	0.000
I25.2 Old myocardial infarction	0.998	0.002	0.000
I25.9 Chronic ischaemic heart disease, unspecified	0.998	0.002	0.000
E78.5 Hyperlipidaemia, unspecified	0.989	0.011	0.000
E78.8 Other disorders of lipoprotein metabolism	0.944	0.056	0.000
I21 Acute myocardial infarction	0.919	0.081	0.000
E70-E90 Metabolic disorders	0.900	0.100	0.000
E83 Disorders of mineral metabolism	0.890	0.110	0.000
I24 Other acute ischaemic heart diseases	0.882	0.118	0.000
E83.5 Disorders of calcium metabolism	0.878	0.122	0.000
I24.8 Other forms of acute ischaemic heart disease	0.870	0.130	0.000
I21.9 Acute myocardial infarction, unspecified	0.868	0.132	0.000
E87 Other disorders of fluid, electrolyte and acid-base balance	0.848	0.152	0.000
E83.4 Disorders of magnesium metabolism	0.813	0.187	0.000
I20.1 Angina pectoris with documented spasm	0.808	0.192	0.000
E78.3 Hyperchylomicronaemia	0.803	0.197	0.000
I21.1 Acute transmural myocardial infarction of inferior wall	0.793	0.207	0.000
E87.2 Acidosis	0.792	0.208	0.000
E78.6 Lipoprotein deficiency	0.773	0.227	0.000
I25.4 Coronary artery aneurysm	0.773	0.227	0.000
I21.3 Acute transmural myocardial infarction of unspecified site	0.762	0.238	0.000
E87.5 Hyperkalaemia	0.746	0.254	0.000
E78.9 Disorder of lipoprotein metabolism, unspecified	0.730	0.270	0.000
I25.6 Silent myocardial ischaemia	0.717	0.283	0.000
I25.5 Ischaemic cardiomyopathy	0.702	0.298	0.000
E87.6 Hypokalaemia	0.692	0.308	0.000
E85 Amyloidosis	0.677	0.323	0.000
I23 Certain current complications following acute myocardial infarction	0.676	0.324	0.000
E83.3 Disorders of phosphorus metabolism	0.675	0.325	0.000
E78.4 Other hyperlipidaemia	0.673	0.327	0.000
E84 Cystic fibrosis	0.670	0.330	0.000
E79 Disorders of purine and pyrimidine metabolism	0.669	0.331	0.000
E87.7 Fluid overload	0.668	0.332	0.000
I20.8 Other forms of angina pectoris	0.665	0.335	0.000
I21.X Presumed acute myicardial infaction (unconfirmed)	0.659	0.341	0.000
E78.2 Mixed hyperlipidaemia	0.658	0.342	0.000
E73 Lactose intolerance	0.646	0.354	0.000
E77 Disorders of glycoprotein metabolism	0.646	0.354	0.000
E76 Disorders of glycosaminoglycan metabolism	0.646	0.354	0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.646	0.354	0.000
E72 Other disorders of amino-acid metabolism	0.646	0.354	0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.646	0.354	0.000
E70 Disorders of aromatic amino-acid metabolism	0.646	0.354	0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.646	0.354	0.000
E83.9 Disorder of mineral metabolism, unspecified	0.638	0.361	0.000
E83.8 Other disorders of mineral metabolism	0.638	0.361	0.000
E83.2 Disorders of zinc metabolism	0.638	0.361	0.000
E83.0 Disorders of copper metabolism	0.638	0.361	0.000
I21.4 Acute subendocardial myocardial infarction	0.631	0.369	0.000
I25.3 Aneurysm of heart	0.628	0.372	0.000
E87.4 Mixed disorder of acid-base balance	0.608	0.392	0.000
I25.0 Atherosclerotic cardiovascular disease, so described	0.606	0.394	0.000
E74 Other disorders of carbohydrate metabolism	0.598	0.402	0.000
I24.1 Dressler's syndrome	0.591	0.409	0.000
E87.0 Hyperosmolality and hypernatraemia	0.585	0.414	0.000
E78.1 Pure hyperglyceridaemia	0.566	0.434	0.000
I21.0 Acute transmural myocardial infarction of anterior wall	0.565	0.435	0.000
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified	0.530	0.470	0.000
E85.9 Amyloidosis, unspecified	0.509	0.491	0.000
E85.3 Secondary systemic amyloidosis	0.505	0.495	0.000
E87.1 Hypo-osmolality and hyponatraemia	0.505	0.495	0.000
E84.9 Cystic fibrosis, unspecified	0.504	0.496	0.000
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease	0.504	0.496	0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.503	0.497	0.000
E88 Other metabolic disorders	0.494	0.506	0.000
E85.8 Other amyloidosis	0.485	0.514	0.000
E85.2 Heredofamilial amyloidosis, unspecified	0.485	0.514	0.000
E85.1 Neuropathic heredofamilial amyloidosis	0.485	0.514	0.000
E85.0 Nonneuropathic heredofamilial amyloidosis	0.485	0.514	0.000
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction	0.484	0.515	0.000
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction	0.484	0.515	0.000
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction	0.484	0.515	0.000
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction	0.484	0.515	0.000
I23.2 Ventricular septal defect as current complication following acute myocardial infarction	0.484	0.515	0.000
I23.1 Atrial septal defect as current complication following acute myocardial infarction	0.484	0.515	0.000
I23.0 Haemopericardium as current complication following acute myocardial infarction	0.484	0.515	0.000
E84.8 Cystic fibrosis with other manifestations	0.480	0.520	0.000
E84.1 Cystic fibrosis with intestinal manifestations	0.480	0.520	0.000
E84.0 Cystic fibrosis with pulmonary manifestations	0.480	0.520	0.000
E79.9 Disorder of purine and pyrimidine metabolism, unspecified	0.480	0.520	0.000
E79.8 Other disorders of purine and pyrimidine metabolism	0.480	0.520	0.000
E79.1 Lesch-Nyhan syndrome	0.480	0.520	0.000
E87.3 Alkalosis	0.476	0.524	0.000
E85.4 Organ-limited amyloidosis	0.474	0.526	0.000
E73.9 Lactose intolerance, unspecified	0.463	0.537	0.000
E73.8 Other lactose intolerance	0.463	0.537	0.000
E73.1 Secondary lactase deficiency	0.463	0.537	0.000
E73.0 Congenital lactase deficiency	0.463	0.537	0.000
E70.9 Disorder of aromatic amino-acid metabolism, unspecified	0.463	0.537	0.000
E70.8 Other disorders of aromatic amino-acid metabolism	0.463	0.537	0.000
E70.3 Albinism	0.463	0.537	0.000
E70.2 Disorders of tyrosine metabolism	0.463	0.537	0.000
E70.1 Other hyperphenylalaninaemias	0.463	0.537	0.000
E70.0 Classical phenylketonuria	0.463	0.537	0.000
E71.3 Disorders of fatty-acid metabolism	0.463	0.537	0.000
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified	0.463	0.537	0.000
E71.1 Other disorders of branched-chain amino-acid metabolism	0.463	0.537	0.000
E71.0 Maple-syrup-urine disease	0.463	0.537	0.000
E72.9 Disorder of amino-acid metabolism, unspecified	0.463	0.537	0.000
E72.8 Other specified disorders of amino-acid metabolism	0.463	0.537	0.000
E72.5 Disorders of glycine metabolism	0.463	0.537	0.000
E72.4 Disorders of ornithine metabolism	0.463	0.537	0.000
E72.3 Disorders of lysine and hydroxylysine metabolism	0.463	0.537	0.000
E72.2 Disorders of urea cycle metabolism	0.463	0.537	0.000
E72.1 Disorders of sulphur-bearing amino-acid metabolism	0.463	0.537	0.000
E72.0 Disorders of amino-acid transport	0.463	0.537	0.000
E75.6 Lipid storage disorder, unspecified	0.463	0.537	0.000
E75.5 Other lipid storage disorders	0.463	0.537	0.000
E75.4 Neuronal ceroid lipofuscinosis	0.463	0.537	0.000
E75.3 Sphingolipidosis, unspecified	0.463	0.537	0.000
E75.2 Other sphingolipidosis	0.463	0.537	0.000
E75.1 Other gangliosidosis	0.463	0.537	0.000
E75.0 GM2 gangliosidosis	0.463	0.537	0.000
E76.9 Disorder of glucosaminoglycan metabolism, unspecified	0.463	0.537	0.000
E76.8 Other disorders of glucosaminoglycan metabolism	0.463	0.537	0.000
E76.3 Mucopolysaccharidosis, unspecified	0.463	0.537	0.000
E76.2 Other mucopolysaccharidoses	0.463	0.537	0.000
E76.1 Mucopolysaccharidosis, type II	0.463	0.537	0.000
E76.0 Mucopolysaccharidosis, type I	0.463	0.537	0.000
E77.9 Disorder of glycoprotein metabolism, unspecified	0.463	0.537	0.000
E77.8 Other disorders of glycoprotein metabolism	0.463	0.537	0.000
E77.1 Defects in glycoprotein degradation	0.463	0.537	0.000
E77.0 Defects in posttranslational modification of lysosomal enzymes	0.463	0.537	0.000
Z95.1 Presence of aortocoronary bypass graft	0.459	0.541	0.000
E80 Disorders of porphyrin and bilirubin metabolism	0.441	0.556	0.003
I23.8 Other current complications following acute myocardial infarction	0.443	0.556	0.000
E74.9 Disorder of carbohydrate metabolism, unspecified	0.429	0.571	0.000
E74.8 Other specified disorders of carbohydrate metabolism	0.429	0.571	0.000
E74.4 Disorders of pyruvate metabolism and gluconeogenesis	0.429	0.571	0.000
E74.2 Disorders of galactose metabolism	0.429	0.571	0.000
E74.1 Disorders of fructose metabolism	0.429	0.571	0.000
E74.0 Glycogen storage disease	0.429	0.571	0.000
E89.2 Postprocedural hypoparathyroidism	0.396	0.604	0.000
Z95 Presence of cardiac and vascular implants and grafts	0.388	0.612	0.000
E74.3 Other disorders of intestinal carbohydrate absorption	0.381	0.619	0.000
E89.3 Postprocedural hypopituitarism	0.377	0.623	0.000
E88.8 Other specified metabolic disorders	0.373	0.627	0.000
Z95.5 Presence of coronary angioplasty implant and graft	0.364	0.636	0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified	0.360	0.639	0.000
E89.8 Other postprocedural endocrine and metabolic disorders	0.360	0.639	0.000
E89.5 Postprocedural testicular hypofunction	0.360	0.639	0.000
E89.4 Postprocedural ovarian failure	0.360	0.639	0.000
E89.1 Postprocedural hypoinsulinaemia	0.360	0.639	0.000
E88.9 Metabolic disorder, unspecified	0.354	0.646	0.000
E88.3 Tumour lysis syndrome	0.354	0.646	0.000
E88.1 Lipodystrophy, not elsewhere classified	0.354	0.646	0.000
E88.2 Lipomatosis, not elsewhere classified	0.347	0.653	0.000
E89.6 Postprocedural adrenocortical(-medullary) hypofunction	0.342	0.657	0.000
E80.2 Other porphyria	0.336	0.662	0.002
Z95.9 Presence of cardiac and vascular implant and graft, unspecified	0.337	0.663	0.000
E83.1 Disorders of iron metabolism	0.325	0.674	0.000
E80.7 Disorder of bilirubin metabolism, unspecified	0.316	0.682	0.002
E80.6 Other disorders of bilirubin metabolism	0.316	0.682	0.002
E80.5 Crigler-Najjar syndrome	0.316	0.682	0.002
E80.3 Defects of catalase and peroxydase	0.316	0.682	0.002
E80.1 Porphyria cutanea tarda	0.316	0.682	0.002
E80.0 Hereditary erythropoietic porphyria	0.316	0.682	0.002
Z95.4 Presence of other heart-valve replacement	0.316	0.684	0.000
I24.9 Acute ischaemic heart disease, unspecified	0.308	0.692	0.000
I22 Subsequent myocardial infarction	0.296	0.703	0.000
Z95.3 Presence of xenogenic heart valve	0.296	0.704	0.000
Z95.0 Presence of cardiac pacemaker	0.272	0.728	0.000
E86 Volume depletion	0.267	0.733	0.000
I21.2 Acute transmural myocardial infarction of other sites	0.265	0.735	0.001
Z95.8 Presence of other cardiac and vascular implants and grafts	0.264	0.736	0.000
I20.0 Unstable angina	0.250	0.750	0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction	0.220	0.778	0.002
I22.8 Subsequent myocardial infarction of other sites	0.202	0.798	0.000
Chapter IX Diseases of the circulatory system	0.194	0.806	0.000
I70-I79 Diseases of arteries, arterioles and capillaries	0.192	0.808	0.000
I74 Arterial embolism and thrombosis	0.186	0.814	0.000
I77 Other disorders of arteries and arterioles	0.182	0.818	0.000
Z95.2 Presence of prosthetic heart valve	0.179	0.821	0.000
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified	0.175	0.825	0.001
I22.0 Subsequent myocardial infarction of anterior wall	0.173	0.827	0.000
I77.8 Other specified disorders of arteries and arterioles	0.167	0.833	0.000
I74.5 Embolism and thrombosis of iliac artery	0.167	0.833	0.000
I77.1 Stricture of artery	0.165	0.835	0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities	0.164	0.836	0.000
I77.0 Arteriovenous fistula, acquired	0.162	0.837	0.000
I22.9 Subsequent myocardial infarction of unspecified site	0.157	0.842	0.000
I72 Other aneurysm	0.156	0.844	0.000
I74.0 Embolism and thrombosis of abdominal aorta	0.153	0.847	0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.153	0.847	0.000
I95-I99 Other and unspecified disorders of the circulatory system	0.150	0.850	0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.147	0.853	0.000
I70 Atherosclerosis	0.146	0.854	0.000
I74.2 Embolism and thrombosis of arteries of the upper extremities	0.143	0.856	0.000
I72.0 Aneurysm of carotid artery	0.140	0.860	0.000
I00-I02 Acute rheumatic fever	0.139	0.860	0.000
I74.8 Embolism and thrombosis of other arteries	0.137	0.863	0.000
I97 Postprocedural disorders of circulatory system, not elsewhere classified	0.135	0.865	0.000
I74.4 Embolism and thrombosis of arteries of extremities, unspecified	0.134	0.866	0.000
I74.1 Embolism and thrombosis of other and unspecified parts of aorta	0.133	0.867	0.000
I77.5 Necrosis of artery	0.131	0.869	0.000
I77.4 Coeliac artery compression syndrome	0.131	0.869	0.000
I77.3 Arterial fibromuscular dysplasia	0.131	0.869	0.000
I77.2 Rupture of artery	0.131	0.869	0.000
I27 Other pulmonary heart diseases	0.130	0.870	0.000
I72.8 Aneurysm of other specified arteries	0.129	0.871	0.000
I79.2 Peripheral angiopathy in diseases classified elsewhere	0.124	0.875	0.000
I97.1 Other functional disturbances following cardiac surgery	0.123	0.877	0.000
E89.0 Postprocedural hypothyroidism	0.120	0.880	0.000
I70.1 Atherosclerosis of renal artery	0.118	0.882	0.000
I27.9 Pulmonary heart disease, unspecified	0.118	0.882	0.000
I98 Other disorders of circulatory system in diseases classified elsewhere	0.115	0.885	0.000
I71 Aortic aneurysm and dissection	0.115	0.885	0.000
I22.1 Subsequent myocardial infarction of inferior wall	0.114	0.885	0.001
I72.9 Aneurysm of unspecified site	0.112	0.888	0.000
I72.6 Aneurysm and dissection of vertebral artery	0.112	0.888	0.000
I72.5 Aneurysm and dissection of other precerebral arteries	0.112	0.888	0.000
I72.1 Aneurysm of artery of upper extremity	0.112	0.888	0.000
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.110	0.890	0.000
I79.1 Aortitis in diseases classified elsewhere	0.110	0.890	0.000
I79.0 Aneurysm of aorta in diseases classified elsewhere	0.110	0.890	0.000
I35.2 Aortic (valve) stenosis with insufficiency	0.110	0.890	0.000
I35 Nonrheumatic aortic valve disorders	0.109	0.891	0.000
I28 Other diseases of pulmonary vessels	0.109	0.891	0.000
I30-I52 Other forms of heart disease	0.108	0.892	0.000
I72.2 Aneurysm of renal artery	0.106	0.894	0.000
I70.2 Atherosclerosis of arteries of the extremities	0.105	0.894	0.000
I74.9 Embolism and thrombosis of unspecified artery	0.105	0.895	0.000
I97.2 Postmastectomy lymphoedema syndrome	0.105	0.895	0.000
I70.9 Generalised and unspecified atherosclerosis	0.104	0.895	0.000
I70.8 Atherosclerosis of other arteries	0.104	0.895	0.000
I73 Other peripheral vascular diseases	0.104	0.896	0.000
I31 Other diseases of pericardium	0.103	0.897	0.000
I33 Acute and subacute endocarditis	0.102	0.898	0.000
I30 Acute pericarditis	0.101	0.899	0.000
I02 Rheumatic chorea	0.100	0.900	0.000
I01 Rheumatic fever with heart involvement	0.100	0.900	0.000
I00 Rheumatic fever without mention of heart involvement	0.100	0.900	0.000
I27.8 Other specified pulmonary heart diseases	0.100	0.900	0.000
I70.10 Atherosclerosis of renal artery (without gangrene)	0.098	0.902	0.000
I27.2 Other secondary pulmonary hypertension	0.098	0.902	0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture	0.098	0.902	0.000
I97.9 Postprocedural disorder of circulatory system, unspecified	0.097	0.903	0.000
I97.0 Postcardiotomy syndrome	0.097	0.903	0.000
I05-I09 Chronic rheumatic heart diseases	0.097	0.903	0.000
I33.0 Acute and subacute infective endocarditis	0.097	0.903	0.000
I30.9 Acute pericarditis, unspecified	0.096	0.904	0.000
I97.8 Other postprocedural disorders of circulatory system, not elsewhere classified	0.096	0.904	0.000
I31.3 Pericardial effusion (noninflammatory)	0.096	0.904	0.000
I72.3 Aneurysm of iliac artery	0.095	0.905	0.000
I70.0 Atherosclerosis of aorta	0.094	0.906	0.000
I27.1 Kyphoscoliotic heart disease	0.093	0.907	0.000
I10-I15 Hypertensive diseases	0.093	0.907	0.000
I78 Diseases of capillaries	0.093	0.907	0.000
I71.0 Dissection of aorta [any part]	0.091	0.909	0.000
I98.2 Oesophageal varices in diseases classified elsewhere	0.091	0.909	0.000
I35.9 Aortic valve disorder, unspecified	0.090	0.910	0.000
I73.0 Raynaud's syndrome	0.090	0.910	0.000
Z13.0 Special screening examination for diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.088	0.912	0.000
I35.1 Aortic (valve) insufficiency	0.087	0.913	0.000
I31.9 Disease of pericardium, unspecified	0.087	0.913	0.000
I36 Nonrheumatic tricuspid valve disorders	0.085	0.915	0.000
I99 Other and unspecified disorders of circulatory system	0.085	0.915	0.000
I77.6 Arteritis, unspecified	0.085	0.915	0.000
I70.11 Atherosclerosis of renal artery (with gangrene)	0.085	0.915	0.000
I70.21 Atherosclerosis of arteries of extremities (with gangrene)	0.083	0.917	0.000
I98.8 Other specified disorders of circulatory system in diseases classified elsewhere	0.082	0.917	0.000
I98.1 Cardiovascular disorders in other infectious and parasitic diseases classified elsewhere	0.082	0.917	0.000
I98.0 Cardiovascular syphilis	0.082	0.917	0.000
I71.8 Aortic aneurysm of unspecified site, ruptured	0.082	0.917	0.000
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture	0.082	0.917	0.000
I71.5 Thoracoabdominal aortic aneurysm, ruptured	0.082	0.917	0.000
I71.1 Thoracic aortic aneurysm, ruptured	0.082	0.917	0.000
I33.9 Acute endocarditis, unspecified	0.082	0.918	0.000
I28.8 Other specified diseases of pulmonary vessels	0.081	0.919	0.000
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere	0.080	0.919	0.000
I95 Hypotension	0.079	0.921	0.000
I72.4 Aneurysm of artery of lower extremity	0.079	0.921	0.000
I28.9 Disease of pulmonary vessels, unspecified	0.078	0.922	0.000
I28.1 Aneurysm of pulmonary artery	0.078	0.922	0.000
I28.0 Arteriovenous fistula of pulmonary vessels	0.078	0.922	0.000
I52 Other heart disorders in diseases classified elsewhere	0.078	0.922	0.000
I48 Atrial fibrillation and flutter	0.078	0.922	0.000
I43 Cardiomyopathy in diseases classified elsewhere	0.078	0.922	0.000
I41 Myocarditis in diseases classified elsewhere	0.078	0.922	0.000
I40 Acute myocarditis	0.078	0.922	0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere	0.078	0.922	0.000
I32 Pericarditis in diseases classified elsewhere	0.078	0.922	0.000
I27.0 Primary pulmonary hypertension	0.076	0.924	0.000
I30.1 Infective pericarditis	0.076	0.924	0.000
I35.8 Other aortic valve disorders	0.075	0.925	0.000
I70.81 Atherosclerosis of other arteries (with gangrene)	0.075	0.925	0.000
I70.80 Atherosclerosis of other arteries (without gangrene)	0.075	0.925	0.000
I70.91 Generalized and unspecified atherosclerosis (with gangrene)	0.075	0.925	0.000
I70.90 Generalized and unspecified atherosclerosis (without gangrene)	0.075	0.925	0.000
I73.1 Thromboangiitis obliterans [Buerger]	0.075	0.925	0.000
I12 Hypertensive renal disease	0.075	0.925	0.000
I31.0 Chronic adhesive pericarditis	0.074	0.926	0.000
I31.8 Other specified diseases of pericardium	0.074	0.926	0.000
I31.2 Haemopericardium, not elsewhere classified	0.074	0.926	0.000
I31.1 Chronic constrictive pericarditis	0.074	0.926	0.000
I38 Endocarditis, valve unspecified	0.074	0.926	0.000
I95.9 Hypotension, unspecified	0.074	0.926	0.000
I30.8 Other forms of acute pericarditis	0.073	0.927	0.000
I30.0 Acute nonspecific idiopathic pericarditis	0.073	0.927	0.000
I71.3 Abdominal aortic aneurysm, ruptured	0.073	0.927	0.000
I77.9 Disorder of arteries and arterioles, unspecified	0.072	0.927	0.000
I01.9 Acute rheumatic heart disease, unspecified	0.072	0.928	0.000
I01.8 Other acute rheumatic heart disease	0.072	0.928	0.000
I01.2 Acute rheumatic myocarditis	0.072	0.928	0.000
I01.1 Acute rheumatic endocarditis	0.072	0.928	0.000
I01.0 Acute rheumatic pericarditis	0.072	0.928	0.000
I02.9 Rheumatic chorea without heart involvement	0.072	0.928	0.000
I02.0 Rheumatic chorea with heart involvement	0.072	0.928	0.000
I07 Rheumatic tricuspid valve diseases	0.072	0.928	0.000
I06 Rheumatic aortic valve diseases	0.070	0.930	0.000
I05 Rheumatic mitral valve diseases	0.070	0.930	0.000
I11 Hypertensive heart disease	0.069	0.931	0.000
I36.1 Nonrheumatic tricuspid (valve) insufficiency	0.069	0.931	0.000
I49.9 Cardiac arrhythmia, unspecified	0.069	0.931	0.000
I49 Other cardiac arrhythmias	0.068	0.932	0.000
I70.20 Atherosclerosis of arteries of extremities (without gangrene)	0.068	0.932	0.000
I70.01 Atherosclerosis of aorta (with gangrene)	0.068	0.932	0.000
I78.0 Hereditary haemorrhagic telangiectasia	0.067	0.932	0.000
I13 Hypertensive heart and renal disease	0.067	0.933	0.000
I78.9 Disease of capillaries, unspecified	0.066	0.933	0.000
I09 Other rheumatic heart diseases	0.065	0.934	0.000
I73.8 Other specified peripheral vascular diseases	0.065	0.934	0.000
I36.9 Nonrheumatic tricuspid valve disorder, unspecified	0.061	0.938	0.000
I36.8 Other nonrheumatic tricuspid valve disorders	0.061	0.938	0.000
I36.2 Nonrheumatic tricuspid (valve) stenosis with insufficiency	0.061	0.938	0.000
I36.0 Nonrheumatic tricuspid (valve) stenosis	0.061	0.938	0.000
I37 Pulmonary valve disorders	0.061	0.939	0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture	0.061	0.939	0.000
I12.0 Hypertensive renal disease with renal failure	0.060	0.940	0.000
I26 Pulmonary embolism	0.060	0.940	0.000
I78.8 Other diseases of capillaries	0.059	0.941	0.000
I15 Secondary hypertension	0.059	0.941	0.000
I70.00 Atherosclerosis of aorta (without gangrene)	0.057	0.942	0.000
E80.4 Gilbert's syndrome	0.049	0.943	0.008
I12.9 Hypertensive renal disease without renal failure	0.057	0.943	0.000
I11.9 Hypertensive heart disease without (congestive) heart failure	0.056	0.944	0.000
I32.8 Pericarditis in other diseases classified elsewhere	0.056	0.944	0.000
I32.1 Pericarditis in other infectious and parasitic diseases classified elsewhere	0.056	0.944	0.000
I32.0 Pericarditis in bacterial diseases classified elsewhere	0.056	0.944	0.000
I39.8 Endocarditis, valve unspecified, in diseases classified elsewhere	0.056	0.944	0.000
I39.4 Multiple valve disorders in diseases classified elsewhere	0.056	0.944	0.000
I39.3 Pulmonary valve disorders in diseases classified elsewhere	0.056	0.944	0.000
I39.2 Tricuspid valve disorders in diseases classified elsewhere	0.056	0.944	0.000
I39.1 Aortic valve disorders in diseases classified elsewhere	0.056	0.944	0.000
I39.0 Mitral valve disorders in diseases classified elsewhere	0.056	0.944	0.000
I40.9 Acute myocarditis, unspecified	0.056	0.944	0.000
I40.8 Other acute myocarditis	0.056	0.944	0.000
I40.1 Isolated myocarditis	0.056	0.944	0.000
I40.0 Infective myocarditis	0.056	0.944	0.000
I41.8 Myocarditis in other diseases classified elsewhere	0.056	0.944	0.000
I41.2 Myocarditis in other infectious and parasitic diseases classified elsewhere	0.056	0.944	0.000
I41.1 Myocarditis in viral diseases classified elsewhere	0.056	0.944	0.000
I41.0 Myocarditis in bacterial diseases classified elsewhere	0.056	0.944	0.000
I43.8 Cardiomyopathy in other diseases classified elsewhere	0.056	0.944	0.000
I43.2 Cardiomyopathy in nutritional diseases	0.056	0.944	0.000
I43.1 Cardiomyopathy in metabolic diseases	0.056	0.944	0.000
I43.0 Cardiomyopathy in infectious and parasitic diseases classified elsewhere	0.056	0.944	0.000
I48.9 Atrial fibrillation and atrial flutter, unspecified	0.056	0.944	0.000
I48.4 Atypical atrial flutter	0.056	0.944	0.000
I48.3 Typical atrial flutter	0.056	0.944	0.000
I48.2 Chronic atrial fibrillation	0.056	0.944	0.000
I48.1 Persistent atrial fibrillation	0.056	0.944	0.000
I48.0 Paroxysmal atrial fibrillation	0.056	0.944	0.000
I52.8 Other heart disorders in other diseases classified elsewhere	0.056	0.944	0.000
I52.1 Other heart disorders in other infectious and parasitic diseases classified elsewhere	0.056	0.944	0.000
I52.0 Other heart disorders in bacterial diseases classified elsewhere	0.056	0.944	0.000
I35.0 Aortic (valve) stenosis	0.056	0.944	0.000
I05.2 Mitral stenosis with insufficiency	0.054	0.946	0.000
I05.0 Mitral stenosis	0.054	0.946	0.000
I07.1 Tricuspid insufficiency	0.054	0.946	0.000
I05.1 Rheumatic mitral insufficiency	0.052	0.948	0.000
I07.9 Tricuspid valve disease, unspecified	0.052	0.948	0.000
I07.8 Other tricuspid valve diseases	0.052	0.948	0.000
I07.2 Tricuspid stenosis with insufficiency	0.052	0.948	0.000
I07.0 Tricuspid stenosis	0.052	0.948	0.000
I06.9 Rheumatic aortic valve disease, unspecified	0.050	0.950	0.000
I06.8 Other rheumatic aortic valve diseases	0.050	0.950	0.000
I06.2 Rheumatic aortic stenosis with insufficiency	0.050	0.950	0.000
I06.1 Rheumatic aortic insufficiency	0.050	0.950	0.000
I06.0 Rheumatic aortic stenosis	0.050	0.950	0.000
I05.8 Other mitral valve diseases	0.050	0.950	0.000
I49.2 Junctional premature depolarisation	0.049	0.951	0.000
I95.0 Idiopathic hypotension	0.049	0.951	0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture	0.048	0.952	0.000
I13.9 Hypertensive heart and renal disease, unspecified	0.048	0.952	0.000
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure	0.048	0.952	0.000
I13.1 Hypertensive heart and renal disease with renal failure	0.048	0.952	0.000
I13.0 Hypertensive heart and renal disease with (congestive) heart failure	0.048	0.952	0.000
I46 Cardiac arrest	0.048	0.952	0.000
I09.8 Other specified rheumatic heart diseases	0.047	0.953	0.000
I09.2 Chronic rheumatic pericarditis	0.047	0.953	0.000
I09.1 Rheumatic diseases of endocardium, valve unspecified	0.047	0.953	0.000
I09.0 Rheumatic myocarditis	0.047	0.953	0.000
I95.8 Other hypotension	0.045	0.954	0.000
I95.2 Hypotension due to drugs	0.045	0.955	0.000
I11.0 Hypertensive heart disease with (congestive) heart failure	0.045	0.955	0.000
I37.9 Pulmonary valve disorder, unspecified	0.044	0.956	0.000
I37.8 Other pulmonary valve disorders	0.044	0.956	0.000
I37.2 Pulmonary valve stenosis with insufficiency	0.044	0.956	0.000
I37.0 Pulmonary valve stenosis	0.044	0.956	0.000
I09.9 Rheumatic heart disease, unspecified	0.043	0.957	0.000
I15.8 Other secondary hypertension	0.042	0.958	0.000
I15.2 Hypertension secondary to endocrine disorders	0.042	0.958	0.000
I15.0 Renovascular hypertension	0.042	0.958	0.000
I26.0 Pulmonary embolism with mention of acute cor pulmonale	0.042	0.958	0.000
I49.4 Other and unspecified premature depolarisation	0.041	0.959	0.000
I49.8 Other specified cardiac arrhythmias	0.040	0.960	0.000
I34 Nonrheumatic mitral valve disorders	0.040	0.960	0.000
I15.1 Hypertension secondary to other renal disorders	0.039	0.961	0.000
I15.9 Seconday hypertension, unspecified	0.038	0.962	0.000
I49.3 Ventricular premature depolarisation	0.038	0.962	0.000
I49.1 Atrial premature depolarisation	0.037	0.963	0.000
I05.9 Mitral valve disease, unspecified	0.036	0.964	0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances	0.036	0.964	0.000
I78.1 Naevus, nonneoplastic	0.035	0.965	0.000
T36-T50 Poisoning by drugs, medicaments and biological substances	0.035	0.965	0.000
I46.1 Sudden cardiac death, so described	0.035	0.965	0.000
I49.0 Ventricular fibrillation and flutter	0.035	0.965	0.000
I47 Paroxysmal tachycardia	0.034	0.966	0.000
I49.5 Sick sinus syndrome	0.034	0.966	0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs	0.034	0.966	0.000
T46 Poisoning by agents primarily affecting the cardiovascular system	0.033	0.967	0.000
T50.9 Other and unspecified drugs, medicaments and biological substances	0.033	0.967	0.000
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics	0.033	0.967	0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.031	0.968	0.000
I34.8 Other nonrheumatic mitral valve disorders	0.031	0.969	0.000
I08 Multiple valve diseases	0.031	0.969	0.000
I46.0 Cardiac arrest with successful resuscitation	0.031	0.969	0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.031	0.969	0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.031	0.969	0.000
I50 Heart failure	0.031	0.969	0.000
T42.1 Iminostilbenes	0.031	0.969	0.000
T39.0 Salicylates	0.030	0.970	0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.030	0.970	0.000
T42.0 Hydantoin derivatives	0.030	0.970	0.000
T50.4 Drugs affecting uric acid metabolism	0.029	0.971	0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs	0.028	0.972	0.000
T47.2 Stimulant laxatives	0.028	0.972	0.000
I42 Cardiomyopathy	0.028	0.972	0.000
I37.1 Pulmonary valve insufficiency	0.027	0.972	0.001
T50.8 Diagnostic agents	0.027	0.973	0.000
T46.1 Calcium-channel blockers	0.027	0.973	0.000
I34.2 Nonrheumatic mitral (valve) stenosis	0.027	0.973	0.000
T46.5 Other antihypertensive drugs, not elsewhere classified	0.026	0.974	0.000
T50.7 Analeptics and opioid receptor antagonists	0.026	0.974	0.000
T50.6 Antidotes and chelating agents, not elsewhere classified	0.026	0.974	0.000
T50.5 Appetite depressants	0.026	0.974	0.000
T50.3 Electrolytic, caloric and water-balance agents	0.026	0.974	0.000
T50.1 Loop [high-ceiling] diuretics	0.026	0.974	0.000
T50.0 Mineralocorticoids and their antagonists	0.026	0.974	0.000
I08.2 Disorders of both aortic and tricuspid valves	0.025	0.974	0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs	0.025	0.975	0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system	0.025	0.975	0.000
T41 Poisoning by anaesthetics and therapeutic gases	0.025	0.975	0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics	0.025	0.975	0.000
H40.1 Primary open-angle glaucoma	0.000	0.975	0.025
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs	0.025	0.975	0.000
T47.1 Other antacids and anti-gastric-secretion drugs	0.025	0.975	0.000
T38.1 Thyroid hormones and substitutes	0.024	0.975	0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants	0.024	0.975	0.000
T42.5 Mixed antiepileptics, not elsewhere classified	0.024	0.975	0.000
T42.3 Barbiturates	0.024	0.975	0.000
T42.2 Succinimides and oxazolidinediones	0.024	0.975	0.000
I42.8 Other cardiomyopathies	0.024	0.976	0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified	0.024	0.976	0.000
T36 Poisoning by systemic antibiotics	0.024	0.976	0.000
I47.9 Paroxysmal tachycardia, unspecified	0.024	0.976	0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified	0.024	0.976	0.000
T46.9 Other and unspecified agents primarily affecting the cardiovascular system	0.024	0.976	0.000
T46.8 Antivaricose drugs, including sclerosing agents	0.024	0.976	0.000
T46.7 Peripheral vasodilators	0.024	0.976	0.000
T46.3 Coronary vasodilators, not elsewhere classified	0.024	0.976	0.000
T46.2 Other antidysrhythmic drugs, not elsewhere classified	0.024	0.976	0.000
T46.0 Cardiac-stimulant glycosides and drugs of similar action	0.024	0.976	0.000
T39.1 4-Aminophenol derivatives	0.024	0.976	0.000
I45 Other conduction disorders	0.023	0.976	0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.023	0.977	0.000
I34.1 Mitral (valve) prolapse	0.023	0.977	0.000
I34.9 Nonrheumatic mitral valve disorder, unspecified	0.023	0.977	0.000
I08.9 Multiple valve disease, unspecified	0.023	0.977	0.000
I08.8 Other multiple valve diseases	0.023	0.977	0.000
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified	0.023	0.977	0.000
T47.8 Other agents primarily affecting the gastro-intestinal system	0.023	0.977	0.000
T47.7 Emetics	0.023	0.977	0.000
T47.6 Antidiarrhoeal drugs	0.023	0.977	0.000
T47.5 Digestants	0.023	0.977	0.000
T47.4 Other laxatives	0.023	0.977	0.000
T47.3 Saline and osmotic laxatives	0.023	0.977	0.000
T47.0 Histamine H(2)-receptor antagonists	0.023	0.977	0.000
T39.4 Antirheumatics, not elsewhere classified	0.022	0.978	0.000
T39.2 Pyrazolone derivatives	0.022	0.978	0.000
I50.9 Heart failure, unspecified	0.022	0.978	0.000
T38.9 Other and unspecified hormone antagonists	0.022	0.978	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations