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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs11598494
log Bayes Factor = 8.70863
Chromosome 10   position 6,178,941  (GRCh37) Explore rs11598494 on Ensembl!
Variant rs11598494 is part of Cluster X0323

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E10.1 With ketoacidosis
0.000 0.002 0.998
E10.3 With ophthalmic complications
0.000 0.002 0.998
E10.9 Without complications
0.000 0.007 0.993
E20-E35 Disorders of other endocrine glands
0.000 0.015 0.985
E04 Other non-toxic goitre
0.000 0.024 0.976
E04.2 Non-toxic multinodular goitre
0.000 0.025 0.975
E23 Hypofunction and other disorders of pituitary gland
0.000 0.034 0.966
E22 Hyperfunction of pituitary gland
0.000 0.085 0.915
E23.0 Hypopituitarism
0.000 0.102 0.898
E10.2 With renal complications
0.000 0.106 0.894
E40-E46 Malnutrition
0.000 0.120 0.880
E23.6 Other disorders of pituitary gland
0.000 0.138 0.862
E03.8 Other specified hypothyroidism
0.000 0.139 0.861
E22.0 Acromegaly and pituitary gigantism
0.000 0.139 0.861
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.139 0.861
E65-E68 Obesity and other hyperalimentation
0.000 0.157 0.843
E23.2 Diabetes insipidus
0.000 0.164 0.836
E13 Other specified diabetes mellitus
0.000 0.170 0.830
E14 Unspecified diabetes mellitus
0.000 0.200 0.800
E46 Unspecified protein-energy malnutrition
0.000 0.205 0.795
E66 Obesity
0.000 0.212 0.788
E10.5 With peripheral circulatory complications
0.000 0.220 0.780
E20 Hypoparathyroidism
0.000 0.221 0.779
E06 Thyroiditis
0.000 0.226 0.774
E10.6 With other specified complications
0.000 0.230 0.770
E27 Other disorders of adrenal gland
0.000 0.232 0.768
E29 Testicular dysfunction
0.000 0.234 0.766
E66.8 Other obesity
0.000 0.247 0.753
E26 Hyperaldosteronism
0.000 0.250 0.750
E10.4 With neurological complications
0.000 0.259 0.741
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.263 0.737
E13.9 Without complications
0.000 0.267 0.733
E14.9 Without complications
0.000 0.269 0.731
E03.1 Congenital hypothyroidism without goitre
0.000 0.275 0.725
E22.1 Hyperprolactinaemia
0.000 0.276 0.724
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.278 0.722
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.292 0.708
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.294 0.706
E32 Diseases of thymus
0.000 0.294 0.706
E31 Polyglandular dysfunction
0.000 0.294 0.706
E30 Disorders of puberty, not elsewhere classified
0.000 0.294 0.706
E04.8 Other specified non-toxic goitre
0.000 0.300 0.700
E27.1 Primary adrenocortical insufficiency
0.000 0.301 0.699
E11 Non-insulin-dependent diabetes mellitus
0.000 0.304 0.696
E10.7 With multiple complications
0.000 0.305 0.694
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.307 0.693
E23.1 Drug-induced hypopituitarism
0.000 0.307 0.693
E24 Cushing's syndrome
0.000 0.318 0.682
E25 Adrenogenital disorders
0.000 0.319 0.680
E34 Other endocrine disorders
0.000 0.321 0.679
E23.7 Disorder of pituitary gland, unspecified
0.000 0.326 0.674
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.327 0.672
E66.0 Obesity due to excess calories
0.000 0.330 0.670
E10.8 With unspecified complications
0.000 0.343 0.657
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.344 0.656
E22.8 Other hyperfunction of pituitary gland
0.000 0.344 0.656
E06.3 Autoimmune thyroiditis
0.000 0.345 0.655
E27.2 Addisonian crisis
0.000 0.359 0.641
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.367 0.633
E05.9 Thyrotoxicosis, unspecified
0.000 0.368 0.632
E11.1 With ketoacidosis
0.000 0.368 0.632
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.369 0.631
E45 Retarded development following protein-energy malnutrition
0.000 0.369 0.631
E43 Unspecified severe protein-energy malnutrition
0.000 0.369 0.631
E42 Marasmic kwashiorkor
0.000 0.369 0.631
E41 Nutritional marasmus
0.000 0.369 0.631
E40 Kwashiorkor
0.000 0.369 0.631
E20.9 Hypoparathyroidism, unspecified
0.000 0.369 0.631
E11.0 With coma
0.000 0.370 0.630
E14.6 With other specified complications
0.000 0.378 0.622
E29.1 Testicular hypofunction
0.000 0.378 0.622
E05.5 Thyroid crisis or storm
0.000 0.383 0.617
E05.4 Thyrotoxicosis factitia
0.000 0.383 0.617
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.383 0.617
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.383 0.617
E14.5 With peripheral circulatory complications
0.000 0.393 0.607
E67 Other hyperalimentation
0.000 0.395 0.604
E68 Sequelae of hyperalimentation
0.000 0.395 0.604
E11.4 With neurological complications
0.000 0.396 0.604
E13.8 With unspecified complications
0.000 0.405 0.595
E13.7 With multiple complications
0.000 0.405 0.595
E13.6 With other specified complications
0.000 0.405 0.595
E13.5 With peripheral circulatory complications
0.000 0.405 0.595
E13.4 With neurological complications
0.000 0.405 0.595
E13.2 With renal complications
0.000 0.405 0.595
E13.1 With ketoacidosis
0.000 0.405 0.595
E13.0 With coma
0.000 0.405 0.595
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.408 0.592
E26.0 Primary hyperaldosteronism
0.000 0.414 0.586
E34.8 Other specified endocrine disorders
0.000 0.414 0.586
E06.9 Thyroiditis, unspecified
0.000 0.415 0.585
E04.1 Non-toxic single thyroid nodule
0.000 0.423 0.577
E14.7 With multiple complications
0.000 0.426 0.573
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.431 0.569
E66.1 Drug-induced obesity
0.000 0.435 0.565
E14.4 With neurological complications
0.000 0.441 0.558
E20.8 Other hypoparathyroidism
0.000 0.441 0.558
E20.1 Pseudohypoparathyroidism
0.000 0.441 0.558
E20.0 Idiopathic hypoparathyroidism
0.000 0.441 0.558
E11.8 With unspecified complications
0.000 0.443 0.557
E06.4 Drug-induced thyroiditis
0.000 0.445 0.555
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.445 0.555
E06.0 Acute thyroiditis
0.000 0.445 0.555
E27.5 Adrenomedullary hyperfunction
0.000 0.449 0.550
E27.0 Other adrenocortical overactivity
0.000 0.449 0.550
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.450 0.550
E28 Ovarian dysfunction
0.000 0.451 0.549
E29.8 Other testicular dysfunction
0.000 0.451 0.549
E29.0 Testicular hyperfunction
0.000 0.451 0.549
E06.5 Other chronic thyroiditis
0.000 0.459 0.540
E14.1 With ketoacidosis
0.000 0.460 0.539
E14.0 With coma
0.000 0.461 0.538
E26.8 Other hyperaldosteronism
0.000 0.462 0.538
E26.1 Secondary hyperaldosteronism
0.000 0.462 0.538
E13.3 With ophthalmic complications
0.000 0.464 0.536
E14.2 Withrenal complications
0.000 0.465 0.535
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.467 0.533
E26.9 Hyperaldosteronism, unspecified
0.000 0.468 0.532
E14.8 With unspecified complications
0.000 0.468 0.532
E29.9 Testicular dysfunction, unspecified
0.000 0.470 0.530
E05.8 Other thyrotoxicosis
0.000 0.470 0.530
E27.8 Other specified disorders of adrenal gland
0.000 0.477 0.523
E24.9 Cushing's syndrome, unspecified
0.000 0.480 0.520
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E11.2 With renal complications
0.000 0.488 0.512
E30.9 Disorder of puberty, unspecified
0.000 0.494 0.506
E30.8 Other disorders of puberty
0.000 0.494 0.506
E30.1 Precocious puberty
0.000 0.494 0.506
E30.0 Delayed puberty
0.000 0.494 0.506
E31.9 Polyglandular dysfunction, unspecified
0.000 0.494 0.506
E31.8 Other polyglandular dysfunction
0.000 0.494 0.506
E31.1 Polyglandular hyperfunction
0.000 0.494 0.506
E31.0 Autoimmune polyglandular failure
0.000 0.494 0.506
E32.9 Disease of thymus, unspecified
0.000 0.494 0.506
E32.8 Other diseases of thymus
0.000 0.494 0.506
E32.1 Abscess of thymus
0.000 0.494 0.506
E32.0 Persistent hyperplasia of thymus
0.000 0.494 0.506
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.494 0.506
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.494 0.506
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.494 0.506
E11.7 With multiple complications
0.000 0.501 0.499
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.511 0.489
E24.3 Ectopic ACTH syndrome
0.000 0.511 0.489
E24.1 Nelson's syndrome
0.000 0.511 0.489
E25.9 Adrenogenital disorder, unspecified
0.000 0.512 0.488
E25.8 Other adrenogenital disorders
0.000 0.512 0.488
E34.5 Androgen resistance syndrome
0.000 0.513 0.487
E34.4 Constitutional tall stature
0.000 0.513 0.487
E34.3 Short stature, not elsewhere classified
0.000 0.513 0.487
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.513 0.487
E34.1 Other hypersecretion of intestinal hormones
0.000 0.513 0.487
E07 Other disorders of thyroid
0.000 0.517 0.483
E24.0 Pituitary-dependent Cushing's disease
0.000 0.519 0.481
E24.8 Other Cushing's syndrome
0.000 0.534 0.465
E24.2 Drug-induced Cushing's syndrome
0.000 0.537 0.463
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.537 0.462
E10.0 With coma
0.001 0.545 0.455
E44.1 Mild protein-energy malnutrition
0.000 0.547 0.453
E44.0 Moderate protein-energy malnutrition
0.000 0.547 0.453
E34.0 Carcinoid syndrome
0.000 0.550 0.450
E50-E64 Other nutritional deficiencies
0.000 0.550 0.450
E06.1 Subacute thyroiditis
0.000 0.551 0.448
E14.3 With ophthalmic complications
0.000 0.559 0.441
E67.8 Other specified hyperalimentation
0.000 0.566 0.433
E67.3 Hypervitaminosis D
0.000 0.566 0.433
E67.2 Megavitamin-B6 syndrome
0.000 0.566 0.433
E67.1 Hypercarotenaemia
0.000 0.566 0.433
E67.0 Hypervitaminosis A
0.000 0.566 0.433
E27.9 Disorder of adrenal gland, unspecified
0.000 0.587 0.413
E15 Nondiabetic hypoglycaemic coma
0.000 0.605 0.394
E28.9 Ovarian dysfunction, unspecified
0.000 0.606 0.394
E28.8 Other ovarian dysfunction
0.000 0.606 0.394
E28.1 Androgen excess
0.000 0.606 0.394
E28.0 Oestrogen excess
0.000 0.606 0.394
E28.3 Primary ovarian failure
0.000 0.621 0.379
E04.9 Non-toxic goitre, unspecified
0.000 0.632 0.368
E65 Localised adiposity
0.001 0.642 0.358
E51 Thiamine deficiency
0.000 0.645 0.354
E55 Vitamin D deficiency
0.000 0.645 0.354
E07.1 Dyshormogenetic goitre
0.000 0.653 0.346
E07.0 Hypersecretion of calcitonin
0.000 0.653 0.346
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.655 0.345
E04.0 Non-toxic diffuse goitre
0.001 0.657 0.342
E11.6 With other specified complications
0.000 0.672 0.327
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.677 0.322
E50 Vitamin A deficiency
0.000 0.677 0.322
E60 Dietary zinc deficiency
0.000 0.677 0.322
E59 Dietary selenium deficiency
0.000 0.677 0.322
E54 Ascorbic acid deficiency
0.000 0.677 0.322
E52 Niacin deficiency [pellagra]
0.000 0.677 0.322
E56 Other vitamin deficiencies
0.000 0.683 0.317
E07.9 Disorder of thyroid, unspecified
0.000 0.693 0.307
E58 Dietary calcium deficiency
0.000 0.693 0.307
E34.9 Endocrine disorder, unspecified
0.001 0.699 0.301
E63 Other nutritional deficiencies
0.000 0.709 0.291
E51.2 Wernicke's encephalopathy
0.000 0.714 0.286
E55.9 Vitamin D deficiency, unspecified
0.000 0.714 0.286
E11.3 With ophthalmic complications
0.000 0.728 0.272
E28.2 Polycystic ovarian syndrome
0.000 0.735 0.265
E51.9 Thiamine deficiency, unspecified
0.000 0.746 0.254
E51.8 Other manifestations of thiamine deficiency
0.000 0.746 0.254
E51.1 Beriberi
0.000 0.746 0.254
E55.0 Rickets, active
0.000 0.746 0.254
E50.9 Vitamin A deficiency, unspecified
0.000 0.768 0.231
E50.8 Other manifestations of vitamin A deficiency
0.000 0.768 0.231
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.768 0.231
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.768 0.231
E50.5 Vitamin A deficiency with night blindness
0.000 0.768 0.231
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.768 0.231
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.768 0.231
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.768 0.231
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.768 0.231
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.768 0.231
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.768 0.231
E64.8 Sequelae of other nutritional deficiencies
0.000 0.768 0.231
E64.3 Sequelae of rickets
0.000 0.768 0.231
E64.2 Sequelae of vitamin C deficiency
0.000 0.768 0.231
E64.1 Sequelae of vitamin A deficiency
0.000 0.768 0.231
E64.0 Sequelae of protein-energy malnutrition
0.000 0.768 0.231
E61 Deficiency of other nutrient elements
0.000 0.772 0.228
E56.9 Vitamin deficiency, unspecified
0.000 0.772 0.227
E56.8 Deficiency of other vitamins
0.000 0.772 0.227
E56.0 Deficiency of vitamin E
0.000 0.772 0.227
E16 Other disorders of pancreatic internal secretion
0.000 0.773 0.227
E56.1 Deficiency of vitamin K
0.000 0.777 0.222
E11.5 With peripheral circulatory complications
0.000 0.790 0.210
E63.8 Other specified nutritional deficiencies
0.000 0.791 0.209
E63.1 Imbalance of constituents of food intake
0.000 0.791 0.209
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.791 0.209
E07.8 Other specified disorders of thyroid
0.001 0.804 0.195
E63.9 Nutritional deficiency, unspecified
0.001 0.822 0.178
E53 Deficiency of other B group vitamins
0.001 0.827 0.172
E61.9 Deficiency of nutrient element, unspecified
0.000 0.836 0.163
E61.8 Deficiency of other specified nutrient elements
0.000 0.836 0.163
E61.7 Deficiency of multiple nutrient elements
0.000 0.836 0.163
E61.6 Vanadium deficiency
0.000 0.836 0.163
E61.5 Molybdenum deficiency
0.000 0.836 0.163
E61.4 Chromium deficiency
0.000 0.836 0.163
E61.3 Manganese deficiency
0.000 0.836 0.163
E61.0 Copper deficiency
0.000 0.836 0.163
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.837 0.163
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.837 0.163
E16.4 Abnormal secretion of gastrin
0.000 0.837 0.163
E16.3 Increased secretion of glucagon
0.000 0.837 0.163
E16.1 Other hypoglycaemia
0.000 0.844 0.155
E61.2 Magnesium deficiency
0.000 0.847 0.153
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.001 0.849 0.150
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.000 0.862 0.138
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.872 0.127
I08 Multiple valve diseases
0.000 0.872 0.128
E53.1 Pyridoxine deficiency
0.001 0.876 0.123
E53.0 Riboflavin deficiency
0.001 0.876 0.123
I08.1 Disorders of both mitral and tricuspid valves
0.000 0.880 0.120
E21.5 Disorder of parathyroid gland, unspecified
0.001 0.881 0.119
I08.2 Disorders of both aortic and tricuspid valves
0.000 0.884 0.116
E53.9 Vitamin B deficiency, unspecified
0.001 0.887 0.112
E66.9 Obesity, unspecified
0.000 0.900 0.100
E21.2 Other hyperparathyroidism
0.001 0.901 0.098
E21.4 Other specified disorders of parathyroid gland
0.001 0.903 0.096
I08.8 Other multiple valve diseases
0.000 0.903 0.097
E16.2 Hypoglycaemia, unspecified
0.000 0.906 0.094
I08.0 Disorders of both mitral and aortic valves
0.000 0.906 0.094
E61.1 Iron deficiency
0.000 0.909 0.090
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.001 0.912 0.087
I08.9 Multiple valve disease, unspecified
0.000 0.915 0.085
E21.0 Primary hyperparathyroidism
0.000 0.958 0.041
E11.9 Without complications
0.000 0.959 0.041
H54.4 Blindness, one eye
0.000 0.960 0.040
H54 Blindness and low vision
0.000 0.961 0.039
E70-E90 Metabolic disorders
0.000 0.962 0.038
H54.7 Unspecified visual loss
0.000 0.964 0.036
H54.0 Blindness, both eyes
0.000 0.965 0.035
H54.9 Unspecified visual impairment (binocular)
0.000 0.967 0.033
E74 Other disorders of carbohydrate metabolism
0.000 0.968 0.032
H54.6 Unqualified visual loss, one eye
0.000 0.968 0.032
H54.2 Low vision, both eyes
0.000 0.969 0.031
E88 Other metabolic disorders
0.000 0.970 0.030
E79 Disorders of purine and pyrimidine metabolism
0.000 0.970 0.030
E73 Lactose intolerance
0.000 0.970 0.030
H54.1 Blindness, one eye, low vision, other eye
0.000 0.971 0.029
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.972 0.028
H54.3 Unqualified visual loss, both eyes
0.000 0.972 0.028
E84 Cystic fibrosis
0.000 0.972 0.028
E77 Disorders of glycoprotein metabolism
0.000 0.972 0.028
E76 Disorders of glycosaminoglycan metabolism
0.000 0.972 0.028
E72 Other disorders of amino-acid metabolism
0.000 0.972 0.028
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.972 0.028
E70 Disorders of aromatic amino-acid metabolism
0.000 0.972 0.028
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.972 0.028
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.972 0.028
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.974 0.026
E85 Amyloidosis
0.000 0.976 0.024
E88.8 Other specified metabolic disorders
0.000 0.976 0.024
E88.9 Metabolic disorder, unspecified
0.000 0.976 0.024
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.977 0.023
E88.2 Lipomatosis, not elsewhere classified
0.000 0.977 0.023
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.977 0.023
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.977 0.023
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.977 0.023
E74.2 Disorders of galactose metabolism
0.000 0.977 0.023
E74.1 Disorders of fructose metabolism
0.000 0.977 0.023
E74.0 Glycogen storage disease
0.000 0.977 0.023
H54.5 Low vision, one eye
0.000 0.977 0.023
E73.9 Lactose intolerance, unspecified
0.000 0.977 0.023
J84.1 Other interstitial pulmonary diseases with fibrosis
0.000 0.977 0.023
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.978 0.022
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.978 0.021
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.978 0.021
E79.1 Lesch-Nyhan syndrome
0.000 0.978 0.021
E73.8 Other lactose intolerance
0.000 0.979 0.021
E73.1 Secondary lactase deficiency
0.000 0.979 0.021
E73.0 Congenital lactase deficiency
0.000 0.979 0.021
J84 Other interstitial pulmonary diseases
0.000 0.979 0.021
E75.5 Other lipid storage disorders
0.000 0.979 0.021
I05-I09 Chronic rheumatic heart diseases
0.000 0.979 0.021
E75.6 Lipid storage disorder, unspecified
0.000 0.979 0.020
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.979 0.020
E75.3 Sphingolipidosis, unspecified
0.000 0.979 0.020
E75.2 Other sphingolipidosis
0.000 0.979 0.020
E75.1 Other gangliosidosis
0.000 0.979 0.020
E75.0 GM2 gangliosidosis
0.000 0.979 0.020
E84.9 Cystic fibrosis, unspecified
0.000 0.979 0.020
E84.8 Cystic fibrosis with other manifestations
0.000 0.980 0.020
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.980 0.020
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.980 0.020
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.980 0.020
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.980 0.020
E70.3 Albinism
0.000 0.980 0.020
E70.2 Disorders of tyrosine metabolism
0.000 0.980 0.020
E70.1 Other hyperphenylalaninaemias
0.000 0.980 0.020
E70.0 Classical phenylketonuria
0.000 0.980 0.020
E71.3 Disorders of fatty-acid metabolism
0.000 0.980 0.020
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.980 0.020
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.980 0.020
E71.0 Maple-syrup-urine disease
0.000 0.980 0.020
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.980 0.020
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.980 0.020
E72.5 Disorders of glycine metabolism
0.000 0.980 0.020
E72.4 Disorders of ornithine metabolism
0.000 0.980 0.020
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.980 0.020
E72.2 Disorders of urea cycle metabolism
0.000 0.980 0.020
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.980 0.020
E72.0 Disorders of amino-acid transport
0.000 0.980 0.020
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.980 0.020
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.980 0.020
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.980 0.020
E76.2 Other mucopolysaccharidoses
0.000 0.980 0.020
E76.1 Mucopolysaccharidosis, type II
0.000 0.980 0.020
E76.0 Mucopolysaccharidosis, type I
0.000 0.980 0.020
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.980 0.020
E77.8 Other disorders of glycoprotein metabolism
0.000 0.980 0.020
E77.1 Defects in glycoprotein degradation
0.000 0.980 0.020
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.980 0.020
J84.8 Other specified interstitial pulmonary diseases
0.000 0.980 0.020
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.981 0.019
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.981 0.019
E85.9 Amyloidosis, unspecified
0.000 0.982 0.018
E85.8 Other amyloidosis
0.000 0.982 0.018
E21.3 Hyperparathyroidism, unspecified
0.002 0.982 0.016
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.982 0.017
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.982 0.017
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.982 0.017
E85.3 Secondary systemic amyloidosis
0.000 0.983 0.017
E80.2 Other porphyria
0.000 0.983 0.017
E80.6 Other disorders of bilirubin metabolism
0.000 0.983 0.017
J84.9 Interstitial pulmonary disease, unspecified
0.000 0.983 0.017
J80-J84 Other respiratory diseases principally affecting the interstitium
0.000 0.984 0.016
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.984 0.016
E80.5 Crigler-Najjar syndrome
0.000 0.984 0.016
E80.3 Defects of catalase and peroxydase
0.000 0.984 0.016
E80.0 Hereditary erythropoietic porphyria
0.000 0.984 0.016
E86 Volume depletion
0.000 0.984 0.016
J80 Adult respiratory distress syndrome
0.000 0.985 0.015
E88.3 Tumour lysis syndrome
0.000 0.985 0.015
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.985 0.015
J84.0 Alveolar and parietoalveolar conditions
0.000 0.985 0.015
C62.9 Testis, unspecified
0.015 0.985 0.000
E80.1 Porphyria cutanea tarda
0.000 0.986 0.014
J82 Pulmonary eosinophilia, not elsewhere classified
0.000 0.986 0.014
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.986 0.014
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.986 0.014
E89.5 Postprocedural testicular hypofunction
0.000 0.986 0.014
I05 Rheumatic mitral valve diseases
0.000 0.986 0.014
E89.3 Postprocedural hypopituitarism
0.000 0.986 0.014
I09 Other rheumatic heart diseases
0.000 0.986 0.013
E89.4 Postprocedural ovarian failure
0.000 0.987 0.013
I06 Rheumatic aortic valve diseases
0.000 0.987 0.013
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.987 0.013
E85.4 Organ-limited amyloidosis
0.000 0.987 0.012
E89.0 Postprocedural hypothyroidism
0.000 0.987 0.013
E89.1 Postprocedural hypoinsulinaemia
0.000 0.988 0.012
I05.0 Mitral stenosis
0.000 0.988 0.012
J81 Pulmonary oedema
0.000 0.988 0.012
N48.8 Other specified disorders of penis
0.000 0.989 0.011
E80.4 Gilbert's syndrome
0.000 0.989 0.011
I07 Rheumatic tricuspid valve diseases
0.000 0.989 0.010
C62 Malignant neoplasm of testis
0.011 0.989 0.000
E53.8 Deficiency of other specified B group vitamins
0.001 0.990 0.009
I05.8 Other mitral valve diseases
0.000 0.990 0.010
I05.1 Rheumatic mitral insufficiency
0.000 0.990 0.010
I09.8 Other specified rheumatic heart diseases
0.000 0.990 0.010
I09.2 Chronic rheumatic pericarditis
0.000 0.990 0.010
I09.1 Rheumatic diseases of endocardium, valve unspecified
0.000 0.990 0.010
I09.0 Rheumatic myocarditis
0.000 0.990 0.010
C62.1 Descended testis
0.010 0.990 0.000
I06.9 Rheumatic aortic valve disease, unspecified
0.000 0.990 0.009
I06.8 Other rheumatic aortic valve diseases
0.000 0.990 0.009
I06.2 Rheumatic aortic stenosis with insufficiency
0.000 0.990 0.009
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.990 0.009
E89.2 Postprocedural hypoparathyroidism
0.000 0.991 0.009
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.991 0.009
I06.1 Rheumatic aortic insufficiency
0.000 0.991 0.009
C79.8 Secondary malignant neoplasm of other specified sites
0.009 0.991 0.000
I73.9 Peripheral vascular disease, unspecified
0.000 0.991 0.009
I09.9 Rheumatic heart disease, unspecified
0.000 0.992 0.008
I06.0 Rheumatic aortic stenosis
0.000 0.992 0.008
I05.2 Mitral stenosis with insufficiency
0.000 0.992 0.008
I07.9 Tricuspid valve disease, unspecified
0.000 0.992 0.008
I07.8 Other tricuspid valve diseases
0.000 0.992 0.008
I07.2 Tricuspid stenosis with insufficiency
0.000 0.992 0.008
I07.0 Tricuspid stenosis
0.000 0.992 0.008
C62.0 Undescended testis
0.008 0.992 0.000
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.993 0.007
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.993 0.007
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.993 0.007
H53-H54 Visual disturbances and blindness
0.000 0.993 0.007
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.993 0.007
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.993 0.007
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.993 0.007
I05.9 Mitral valve disease, unspecified
0.000 0.993 0.007
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.993 0.007
E83 Disorders of mineral metabolism
0.000 0.993 0.007
H02.6 Xanthelasma of eyelid
0.000 0.994 0.006
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.994 0.006
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.994 0.006
A87.9 Viral meningitis, unspecified
0.000 0.994 0.006
E78.8 Other disorders of lipoprotein metabolism
0.000 0.994 0.006
E78.6 Lipoprotein deficiency
0.000 0.994 0.006
E78.3 Hyperchylomicronaemia
0.000 0.994 0.005
T79.3 Post-traumatic wound infection, not elsewhere classified
0.000 0.995 0.005
C79.4 Secondary malignant neoplasm of other and unspecified parts of nervous system
0.005 0.995 0.000
G80.9 Infantile cerebral palsy, unspecified
0.000 0.995 0.005
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.995 0.005
E83.8 Other disorders of mineral metabolism
0.000 0.995 0.005
E83.2 Disorders of zinc metabolism
0.000 0.995 0.005
E83.0 Disorders of copper metabolism
0.000 0.995 0.005
E78.2 Mixed hyperlipidaemia
0.000 0.995 0.005
C79 Secondary malignant neoplasm of other sites
0.005 0.995 0.000
M23.36 Other meniscus derangements (Other and unspecified lateral meniscus)
0.005 0.995 0.000
E78.0 Pure hypercholesterolaemia
0.000 0.995 0.005
E78.5 Hyperlipidaemia, unspecified
0.000 0.996 0.004
O03.4 Incomplete, without complication
0.000 0.996 0.004
C79.3 Secondary malignant neoplasm of brain and cerebral meninges
0.004 0.996 0.000
E83.3 Disorders of phosphorus metabolism
0.000 0.996 0.004
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.996 0.004
S83.2 Tear of meniscus, current
0.004 0.996 0.000
M05 Seropositive rheumatoid arthritis
0.000 0.996 0.004
C79.6 Secondary malignant neoplasm of ovary
0.004 0.996 0.000
B95.1 Streptococcus, group B, as the cause of diseases classified to other chapters
0.000 0.996 0.004
E78.1 Pure hyperglyceridaemia
0.000 0.996 0.004
C79.5 Secondary malignant neoplasm of bone and bone marrow
0.004 0.996 0.000
I35.2 Aortic (valve) stenosis with insufficiency
0.000 0.996 0.004
K04.6 Periapical abscess with sinus
0.000 0.996 0.004
W21.9 Unspecified place
0.004 0.996 0.000
G80 Infantile cerebral palsy
0.000 0.996 0.004
A87 Viral meningitis
0.000 0.996 0.004
C79.2 Secondary malignant neoplasm of skin
0.004 0.996 0.000
G80.2 Infantile hemiplegia
0.000 0.996 0.003
C79.0 Secondary malignant neoplasm of kidney and renal pelvis
0.003 0.996 0.000
Z34.8 Supervision of other normal pregnancy
0.000 0.996 0.004
T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
0.000 0.997 0.003

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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