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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs116407893
log Bayes Factor = 15.4883
Chromosome 1   position 45,555,700  (GRCh37) Explore rs116407893 on Ensembl!
Variant rs116407893 is part of Cluster X0051

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
I20-I25 Ischaemic heart diseases
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.999 0.001 0.000
Chapter VII Diseases of the eye and adnexa
0.999 0.001 0.000
I25 Chronic ischaemic heart disease
0.999 0.001 0.000
Chapter XI Diseases of the digestive system
0.996 0.004 0.000
I20 Angina pectoris
0.994 0.006 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.985 0.015 0.000
H40-H42 Glaucoma
0.985 0.015 0.000
I20.0 Unstable angina
0.982 0.018 0.000
Chapter I Certain infectious and parasitic diseases
0.978 0.022 0.000
S20-S29 Injuries to the thorax
0.977 0.023 0.000
K55-K64 Other diseases of intestines
0.977 0.023 0.000
I25.9 Chronic ischaemic heart disease, unspecified
0.977 0.023 0.000
H40 Glaucoma
0.974 0.026 0.000
M05-M14 Inflammatory polyarthropathies
0.973 0.027 0.000
Chapter XIV Diseases of the genitourinary system
0.972 0.028 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.969 0.031 0.000
Chapter VIII Diseases of the ear and mastoid process
0.967 0.033 0.000
S00-S09 Injuries to the head
0.967 0.033 0.000
K59 Other functional intestinal disorders
0.966 0.034 0.000
N20-N23 Urolithiasis
0.966 0.034 0.000
K80-K87 Disorders of gallbladder, biliary tract and pancreas
0.965 0.035 0.000
N20 Calculus of kidney and ureter
0.963 0.037 0.000
K59.0 Constipation
0.962 0.038 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.959 0.041 0.000
I25.1 Atherosclerotic heart disease
0.956 0.044 0.000
I30-I52 Other forms of heart disease
0.956 0.044 0.000
N20.0 Calculus of kidney
0.950 0.050 0.000
K82 Other diseases of gallbladder
0.946 0.054 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.944 0.056 0.000
M20-M25 Other joint disorders
0.938 0.062 0.000
A00-A09 Intestinal infectious diseases
0.938 0.062 0.000
I26 Pulmonary embolism
0.929 0.071 0.000
H02 Other disorders of eyelid
0.928 0.072 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.927 0.073 0.000
I20.9 Angina pectoris, unspecified
0.924 0.076 0.000
K65-K67 Diseases of peritoneum
0.922 0.078 0.000
H40.9 Glaucoma, unspecified
0.919 0.081 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.918 0.082 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.917 0.083 0.000
H40.2 Primary angle-closure glaucoma
0.916 0.084 0.000
N20.2 Calculus of kidney with calculus of ureter
0.912 0.088 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.909 0.091 0.000
I26.9 Pulmonary embolism without mention of acute cor pulmonale
0.907 0.093 0.000
K60 Fissure and fistula of anal and rectal regions
0.907 0.093 0.000
K82.8 Other specified diseases of gallbladder
0.902 0.098 0.000
R50-R69 General symptoms and signs
0.897 0.103 0.000
I25.2 Old myocardial infarction
0.896 0.104 0.000
K00-K14 Diseases of oral cavity, salivary glands and jaws
0.894 0.106 0.000
S01 Open wound of head
0.891 0.109 0.000
M05 Seropositive rheumatoid arthritis
0.890 0.110 0.000
A09 Diarrhoea and gastro-enteritis of presumed infectious origin
0.889 0.111 0.000
H65-H75 Diseases of middle ear and mastoid
0.887 0.113 0.000
S29 Other and unspecified injuries of thorax
0.884 0.116 0.000
K86 Other diseases of pancreas
0.883 0.117 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.882 0.118 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.882 0.118 0.000
K35-K38 Diseases of appendix
0.872 0.128 0.000
K60.3 Anal fistula
0.870 0.130 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.868 0.132 0.000
H02.1 Ectropion of eyelid
0.867 0.133 0.000
H55-H59 Other disorders of eye and adnexa
0.865 0.135 0.000
M24 Other specific joint derangements
0.862 0.138 0.000
I44 Atrioventricular and left bundle-branch block
0.856 0.144 0.000
M06 Other rheumatoid arthritis
0.856 0.144 0.000
Chapter XX External causes of morbidity and mortality
0.856 0.144 0.000
I95 Hypotension
0.855 0.145 0.000
A09.9 Gastroenteritis and colitis of unspecified origin
0.854 0.146 0.000
K66 Other disorders of peritoneum
0.852 0.148 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.851 0.149 0.000
Chapter V Mental and behavioural disorders
0.849 0.151 0.000
I33 Acute and subacute endocarditis
0.849 0.151 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.847 0.153 0.000
I47 Paroxysmal tachycardia
0.846 0.154 0.000
S01.8 Open wound of other parts of head
0.844 0.156 0.000
R69 Unknown and unspecified causes of morbidity
0.844 0.156 0.000
I05-I09 Chronic rheumatic heart diseases
0.843 0.157 0.000
I25.8 Other forms of chronic ischaemic heart disease
0.842 0.158 0.000
S22 Fracture of rib(s), sternum and thoracic spine
0.841 0.159 0.000
K04 Diseases of pulp and periapical tissues
0.840 0.160 0.000
H02.8 Other specified disorders of eyelid
0.840 0.160 0.000
N10-N16 Renal tubulo-interstitial diseases
0.837 0.163 0.000
M13 Other arthritis
0.837 0.163 0.000
S27 Injury of other and unspecified intrathoracic organs
0.835 0.165 0.000
M80-M85 Disorders of bone density and structure
0.834 0.166 0.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.830 0.170 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.827 0.173 0.000
I10-I15 Hypertensive diseases
0.827 0.173 0.000
I95.9 Hypotension, unspecified
0.826 0.174 0.000
R55 Syncope and collapse
0.825 0.175 0.000
D50-D53 Nutritional anaemias
0.825 0.175 0.000
K82.1 Hydrops of gallbladder
0.825 0.175 0.000
R42 Dizziness and giddiness
0.825 0.175 0.000
H60-H62 Diseases of external ear
0.823 0.177 0.000
R53 Malaise and fatigue
0.821 0.179 0.000
I22 Subsequent myocardial infarction
0.821 0.179 0.000
S29.9 Unspecified injury of thorax
0.818 0.182 0.000
M22 Disorders of patella
0.811 0.189 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.807 0.193 0.000
R26 Abnormalities of gait and mobility
0.804 0.196 0.000
A08 Viral and other specified intestinal infections
0.802 0.198 0.000
S06 Intracranial injury
0.802 0.198 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.801 0.199 0.000
K66.0 Peritoneal adhesions
0.800 0.200 0.000
W00-W19 Falls
0.799 0.201 0.000
M14 Arthropathies in other diseases classified elsewhere
0.798 0.202 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.798 0.202 0.000
S20 Superficial injury of thorax
0.792 0.207 0.000
A30-A49 Other bacterial diseases
0.791 0.209 0.000
M24.1 Other articular cartilage disorders
0.786 0.214 0.000
S02 Fracture of skull and facial bones
0.783 0.217 0.000
O80-O84 Delivery
0.782 0.218 0.000
D50 Iron deficiency anaemia
0.781 0.219 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.780 0.220 0.000
H05 Disorders of orbit
0.780 0.220 0.000
I21 Acute myocardial infarction
0.776 0.224 0.000
T93 Sequelae of injuries of lower limb
0.776 0.224 0.000
S40-S49 Injuries to the shoulder and upper arm
0.775 0.225 0.000
H18 Other disorders of cornea
0.775 0.225 0.000
N25-N29 Other disorders of kidney and ureter
0.775 0.225 0.000
H90-H95 Other disorders of ear
0.773 0.227 0.000
A80-A89 Viral infections of the central nervous system
0.773 0.227 0.000
I42 Cardiomyopathy
0.773 0.227 0.000
H02.4 Ptosis of eyelid
0.772 0.228 0.000
I24 Other acute ischaemic heart diseases
0.772 0.228 0.000
I33.0 Acute and subacute infective endocarditis
0.772 0.228 0.000
K04.7 Periapical abscess without sinus
0.771 0.229 0.000
H30-H36 Disorders of choroid and retina
0.770 0.230 0.000
H65 Nonsuppurative otitis media
0.770 0.230 0.000
H04 Disorders of lachrymal system
0.769 0.231 0.000
H40.1 Primary open-angle glaucoma
0.768 0.232 0.000
R26.8 Other and unspecified abnormalities of gait and mobility
0.768 0.232 0.000
S90-S99 Injuries to the ankle and foot
0.767 0.233 0.000
R41 Other symptoms and signs involving cognitive functions and awareness
0.767 0.233 0.000
K82.4 Cholesterolosis of gallbladder
0.767 0.233 0.000
K58 Irritable bowel syndrome
0.766 0.234 0.000
I25.5 Ischaemic cardiomyopathy
0.766 0.234 0.000
M20 Acquired deformities of fingers and toes
0.765 0.235 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.764 0.236 0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.764 0.236 0.000
T79-T79 Certain early complications of trauma
0.762 0.238 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.762 0.238 0.000
H66 Suppurative and unspecified otitis media
0.762 0.238 0.000
S09 Other and unspecified injuries of head
0.761 0.239 0.000
K55 Vascular disorders of intestine
0.759 0.241 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.759 0.241 0.000
I44.7 Left bundle-branch block, unspecified
0.757 0.243 0.000
T91 Sequelae of injuries of neck and trunk
0.757 0.243 0.000
R54 Senility
0.755 0.245 0.000
K85 Acute pancreatitis
0.755 0.245 0.000
H10-H13 Disorders of conjunctiva
0.755 0.245 0.000
K37 Unspecified appendicitis
0.751 0.249 0.000
H80-H83 Diseases of inner ear
0.751 0.249 0.000
K57 Diverticular disease of intestine
0.751 0.249 0.000
M65-M68 Disorders of synovium and tendon
0.749 0.251 0.000
H20 Iridocyclitis
0.748 0.252 0.000
M21 Other acquired deformities of limbs
0.748 0.252 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.747 0.253 0.000
N40-N51 Diseases of male genital organs
0.745 0.255 0.000
D50.9 Iron deficiency anaemia, unspecified
0.744 0.256 0.000
B15-B19 Viral hepatitis
0.743 0.256 0.000
S70-S79 Injuries to the hip and thigh
0.743 0.257 0.000
B95-B98 Bacterial, viral and other infectious agents
0.743 0.257 0.000
I10 Essential (primary) hypertension
0.742 0.258 0.000
H16 Keratitis
0.742 0.258 0.000
M00-M03 Infectious arthropathies
0.741 0.259 0.000
H21 Other disorders of iris and ciliary body
0.740 0.260 0.000
M13.9 Arthritis, unspecified
0.739 0.261 0.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.738 0.262 0.000
H40.0 Glaucoma suspect
0.737 0.263 0.000
Chapter XXII Codes for special purposes
0.737 0.263 0.000
Q60-Q64 Congenital malformations of the urinary system
0.737 0.263 0.000
H55 Nystagmus and other irregular eye movements
0.737 0.263 0.000
M07 Psoriatic and enteropathic arthropathies
0.735 0.265 0.000
B25-B34 Other viral diseases
0.733 0.267 0.000
M24.16 Other articular cartilage disorders (Lower leg)
0.732 0.268 0.000
M31 Other necrotising vasculopathies
0.731 0.269 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.730 0.270 0.000
K86.3 Pseudocyst of pancreas
0.730 0.270 0.000
S10-S19 Injuries to the neck
0.725 0.275 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.725 0.275 0.000
K65 Peritonitis
0.724 0.276 0.000
N30-N39 Other diseases of urinary system
0.724 0.276 0.000
N23 Unspecified renal colic
0.723 0.277 0.000
I45 Other conduction disorders
0.723 0.277 0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.722 0.278 0.000
M91-M94 Chondropathies
0.720 0.280 0.000
K60.1 Chronic anal fissure
0.720 0.280 0.000
M10 Gout
0.720 0.280 0.000
I38 Endocarditis, valve unspecified
0.719 0.281 0.000
K10 Other diseases of jaws
0.719 0.281 0.000
I23 Certain current complications following acute myocardial infarction
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.716 0.284 0.000
I25.6 Silent myocardial ischaemia
0.716 0.284 0.000
I25.4 Coronary artery aneurysm
0.716 0.284 0.000
I25.3 Aneurysm of heart
0.716 0.284 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.716 0.284 0.000
K86.8 Other specified diseases of pancreas
0.716 0.284 0.000
I08 Multiple valve diseases
0.716 0.284 0.000
T92 Sequelae of injuries of upper limb
0.715 0.285 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.714 0.285 0.000
I20.8 Other forms of angina pectoris
0.712 0.288 0.000
O60-O75 Complications of labour and delivery
0.712 0.288 0.000
H02.6 Xanthelasma of eyelid
0.711 0.289 0.000
I74 Arterial embolism and thrombosis
0.711 0.289 0.000
M06.0 Seronegative rheumatoid arthritis
0.709 0.290 0.000
K50-K52 Noninfective enteritis and colitis
0.709 0.291 0.000
R57 Shock, not elsewhere classified
0.709 0.291 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.708 0.292 0.000
K06 Other disorders of gingiva and edentulous alveolar ridge
0.708 0.292 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.708 0.292 0.000
M60-M63 Disorders of muscles
0.706 0.294 0.000
H42 Glaucoma in diseases classified elsewhere
0.706 0.294 0.000
A08.4 Viral intestinal infection, unspecified
0.705 0.295 0.000
S01.0 Open wound of scalp
0.705 0.295 0.000
I44.0 Atrioventricular block, first degree
0.705 0.295 0.000
R41.0 Disorientation, unspecified
0.704 0.296 0.000
K57.9 Diverticular disease of intestine, part unspecified, without perforation or abscess
0.703 0.297 0.000
M23 Internal derangement of knee
0.703 0.297 0.000
S50-S59 Injuries to the elbow and forearm
0.703 0.297 0.000
B99-B99 Other infectious diseases
0.701 0.299 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.701 0.299 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.701 0.299 0.000
B65-B83 Helminthiases
0.701 0.299 0.000
B50-B64 Protozoal diseases
0.701 0.299 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.701 0.299 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.701 0.299 0.000
A75-A79 Rickettsioses
0.701 0.299 0.000
A70-A74 Other diseases caused by chlamydiae
0.701 0.299 0.000
A65-A69 Other spirochaetal diseases
0.701 0.299 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.701 0.299 0.000
A20-A28 Certain zoonotic bacterial diseases
0.701 0.299 0.000
A15-A19 Tuberculosis
0.701 0.299 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.701 0.299 0.000
S28 Crushing injury of thorax and traumatic amputation of part of thorax
0.701 0.299 0.000
S26 Injury of heart
0.701 0.299 0.000
S25 Injury of blood vessels of thorax
0.701 0.299 0.000
S24 Injury of nerves and spinal cord at thorax level
0.701 0.299 0.000
S23 Dislocation, sprain and strain of joints and ligaments of thorax
0.701 0.299 0.000
S21 Open wound of thorax
0.701 0.299 0.000
I34 Nonrheumatic mitral valve disorders
0.701 0.299 0.000
K64 Haemorrhoids and perianal venous thrombosis
0.701 0.299 0.000
M06.3 Rheumatoid nodule
0.700 0.300 0.000
H43-H45 Disorders of vitreous body and globe
0.700 0.300 0.000
I47.1 Supraventricular tachycardia
0.700 0.300 0.000
S27.0 Traumatic pneumothorax
0.700 0.300 0.000
I99 Other and unspecified disorders of circulatory system
0.700 0.300 0.000
I21.4 Acute subendocardial myocardial infarction
0.699 0.301 0.000
O85-O92 Complications predominantly related to the puerperium
0.699 0.301 0.000
M11 Other crystal arthropathies
0.699 0.301 0.000
H40.8 Other glaucoma
0.699 0.301 0.000
H40.6 Glaucoma secondary to drugs
0.699 0.301 0.000
H40.5 Glaucoma secondary to other eye disorders
0.699 0.301 0.000
H40.4 Glaucoma secondary to eye inflammation
0.699 0.301 0.000
H40.3 Glaucoma secondary to eye trauma
0.699 0.301 0.000
K58.0 Irritable bowel syndrome with diarrhoea
0.698 0.302 0.000
B35-B49 Mycoses
0.698 0.302 0.000
M12 Other specific arthropathies
0.697 0.303 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.697 0.303 0.000
M08 Juvenile arthritis
0.697 0.303 0.000
V10-V19 Pedal cyclist injured in transport accident
0.696 0.304 0.000
H02.5 Other disorders affecting eyelid function
0.696 0.304 0.000
I77 Other disorders of arteries and arterioles
0.696 0.304 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.696 0.304 0.000
K11 Diseases of salivary glands
0.695 0.305 0.000
H03 Disorders of eyelid in diseases classified elsewhere
0.695 0.305 0.000
H74 Other disorders of middle ear and mastoid
0.694 0.306 0.000
I47.9 Paroxysmal tachycardia, unspecified
0.694 0.306 0.000
S08 Traumatic amputation of part of head
0.693 0.307 0.000
S07 Crushing injury of head
0.693 0.307 0.000
S05 Injury of eye and orbit
0.693 0.307 0.000
S04 Injury of cranial nerves
0.693 0.307 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.693 0.307 0.000
K59.9 Functional intestinal disorder, unspecified
0.693 0.307 0.000
K59.4 Anal spasm
0.693 0.307 0.000
K59.3 Megacolon, not elsewhere classified
0.693 0.307 0.000
K59.2 Neurogenic bowel, not elsewhere classified
0.693 0.307 0.000
R58 Haemorrhage, not elsewhere classified
0.693 0.307 0.000
N22 Calculus of urinary tract in diseases classified elsewhere
0.693 0.307 0.000
I27 Other pulmonary heart diseases
0.692 0.307 0.000
K87 Disorders of gallbladder, biliary tract and pancreas in diseases classified elsewhere
0.692 0.308 0.000
M40-M43 Deforming dorsopathies
0.691 0.309 0.000
I30 Acute pericarditis
0.691 0.309 0.000
S00 Superficial injury of head
0.690 0.309 0.000
N20.9 Urinary calculus, unspecified
0.690 0.310 0.000
K86.2 Cyst of pancreas
0.689 0.311 0.000
I28 Other diseases of pulmonary vessels
0.687 0.313 0.000
K08 Other disorders of teeth and supporting structures
0.687 0.313 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.687 0.313 0.000
R68 Other general symptoms and signs
0.687 0.313 0.000
I52 Other heart disorders in diseases classified elsewhere
0.685 0.315 0.000
I48 Atrial fibrillation and flutter
0.685 0.315 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.685 0.315 0.000
I41 Myocarditis in diseases classified elsewhere
0.685 0.315 0.000
I40 Acute myocarditis
0.685 0.315 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.685 0.315 0.000
I37 Pulmonary valve disorders
0.685 0.315 0.000
I36 Nonrheumatic tricuspid valve disorders
0.685 0.315 0.000
I32 Pericarditis in diseases classified elsewhere
0.685 0.315 0.000
N13 Obstructive and reflux uropathy
0.684 0.316 0.000
O42 Premature rupture of membranes
0.684 0.316 0.000
S30 Superficial injury of abdomen, lower back and pelvis
0.683 0.317 0.000
W13 Fall from, out of or through building or structure
0.683 0.317 0.000
N17-N19 Renal failure
0.683 0.317 0.000
S22.3 Fracture of rib
0.681 0.319 0.000
I49 Other cardiac arrhythmias
0.681 0.319 0.000
T93.0 Sequelae of open wound of lower limb
0.681 0.319 0.000
M22.2 Patellofemoral disorders
0.681 0.319 0.000
H18.4 Corneal degeneration
0.681 0.319 0.000
O00-O08 Pregnancy with abortive outcome
0.679 0.321 0.000
K82.9 Disease of gallbladder, unspecified
0.678 0.322 0.000
K82.3 Fistula of gallbladder
0.678 0.322 0.000
K82.2 Perforation of gallbladder
0.678 0.322 0.000
K82.0 Obstruction of gallbladder
0.678 0.322 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.677 0.323 0.000
S01.5 Open wound of lip and oral cavity
0.677 0.323 0.000
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.676 0.324 0.000
N70-N77 Inflammatory diseases of female pelvic organs
0.676 0.324 0.000
W07 Fall involving chair
0.675 0.325 0.000
K36 Other appendicitis
0.674 0.326 0.000
M14.6 Neuropathic arthropathy
0.673 0.327 0.000
M84 Disorders of continuity of bone
0.673 0.327 0.000
H61 Other disorders of external ear
0.673 0.327 0.000
I95.2 Hypotension due to drugs
0.673 0.327 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.673 0.327 0.000
M34 Systemic sclerosis
0.673 0.327 0.000
M33 Dermatopolymyositis
0.673 0.327 0.000
M32 Systemic lupus erythematosus
0.673 0.327 0.000
M30 Polyarteritis nodosa and related conditions
0.673 0.327 0.000
A07 Other protozoal intestinal diseases
0.672 0.328 0.000
A06 Amoebiasis
0.672 0.328 0.000
A05 Other bacterial foodborne intoxications
0.672 0.328 0.000
A03 Shigellosis
0.672 0.328 0.000
A02 Other Salmonella infections
0.672 0.328 0.000
A01 Typhoid and paratyphoid fevers
0.672 0.328 0.000
A00 Cholera
0.672 0.328 0.000
K86.9 Disease of pancreas, unspecified
0.670 0.330 0.000
K86.1 Other chronic pancreatitis
0.669 0.331 0.000
N47 Redundant prepuce, phimosis and paraphimosis
0.669 0.331 0.000
H57 Other disorders of eye and adnexa
0.668 0.332 0.000
F99-F99 Unspecified mental disorder
0.668 0.332 0.000
X50-X57 Overexertion, travel and privation
0.667 0.332 0.000
I72 Other aneurysm
0.667 0.333 0.000
S32 Fracture of lumbar spine and pelvis
0.666 0.334 0.000
I26.0 Pulmonary embolism with mention of acute cor pulmonale
0.666 0.334 0.000
S22.4 Multiple fractures of ribs
0.665 0.335 0.000
H02.7 Other degenerative disorders of eyelid and periocular area
0.665 0.335 0.000
H02.2 Lagophthalmos
0.665 0.335 0.000
H22 Disorders of iris and ciliary body in diseases classified elsewhere
0.664 0.335 0.000
H19 Disorders of sclera and cornea in diseases classified elsewhere
0.664 0.335 0.000
H17 Corneal scars and opacities
0.664 0.335 0.000
H15 Disorders of sclera
0.664 0.335 0.000
H04.1 Other disorders of lachrymal gland
0.664 0.336 0.000
T66-T78 Other and unspecified effects of external causes
0.662 0.338 0.000
H60 Otitis externa
0.662 0.338 0.000
N42 Other disorders of prostate
0.662 0.338 0.000
K67 Disorders of peritoneum in infectious diseases classified elsewhere
0.661 0.339 0.000
M13.99 Arthritis, unspecified (Site unspecified)
0.661 0.339 0.000
L60-L75 Disorders of skin appendages
0.661 0.339 0.000
R27 Other lack of coordination
0.661 0.339 0.000
Q50-Q56 Congenital malformations of genital organs
0.661 0.339 0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters
0.661 0.339 0.000
K59.1 Functional diarrhoea
0.660 0.339 0.000
S80-S89 Injuries to the knee and lower leg
0.660 0.339 0.000
S20.8 Superficial injuries of other and unspecified parts of thorax
0.660 0.340 0.000
I44.1 Atrioventricular block, second degree
0.660 0.340 0.000
M24.2 Disorder of ligament
0.659 0.341 0.000
S46 Injury of muscle and tendon at shoulder and upper arm level
0.658 0.342 0.000
H91 Other hearing loss
0.658 0.342 0.000
N30 Cystitis
0.658 0.342 0.000
S27.1 Traumatic haemothorax
0.658 0.342 0.000
N12 Tubulo-interstitial nephritis, not specified as acute or chronic
0.658 0.342 0.000
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.657 0.343 0.000
H01 Other inflammation of eyelid
0.657 0.343 0.000
Q80-Q89 Other congenital malformations
0.656 0.344 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.655 0.345 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.654 0.346 0.000
K13 Other diseases of lip and oral mucosa
0.654 0.346 0.000
N00-N08 Glomerular diseases
0.654 0.346 0.000
T31 Burns classified according to extent of body surface involved
0.653 0.346 0.000
F30-F39 Mood [affective] disorders
0.652 0.348 0.000
K07 Dentofacial anomalies [including malocclusion]
0.652 0.348 0.000
T98 Sequelae of other and unspecified effects of external causes
0.652 0.348 0.000
T95 Sequelae of burns, corrosions and frostbite
0.652 0.348 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.652 0.348 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.652 0.348 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.652 0.348 0.000
H66.9 Otitis media, unspecified
0.651 0.348 0.000
M81 Osteoporosis without pathological fracture
0.651 0.349 0.000
K60.5 Anorectal fistula
0.650 0.350 0.000
K60.4 Rectal fistula
0.650 0.350 0.000
K60.0 Acute anal fissure
0.650 0.350 0.000
K04.8 Radicular cyst
0.650 0.350 0.000
I46 Cardiac arrest
0.649 0.350 0.000
H33 Retinal detachments and breaks
0.649 0.351 0.000
W10 Fall on and from stairs and steps
0.649 0.351 0.000
H65.9 Nonsuppurative otitis media, unspecified
0.649 0.351 0.000
I22.9 Subsequent myocardial infarction of unspecified site
0.648 0.352 0.000
M13.91 Arthritis, unspecified (Shoulder region)
0.648 0.352 0.000
K35 Acute appendicitis
0.648 0.352 0.000
I22.1 Subsequent myocardial infarction of inferior wall
0.647 0.353 0.000
K04.9 Other and unspecified diseases of pulp and periapical tissues
0.647 0.353 0.000
M70-M79 Other soft tissue disorders
0.647 0.353 0.000
K61 Abscess of anal and rectal regions
0.646 0.354 0.000
M20.3 Other deformity of hallux (acquired)
0.646 0.354 0.000
I47.2 Ventricular tachycardia
0.645 0.355 0.000
M31.3 Wegener's granulomatosis
0.645 0.355 0.000
H05.0 Acute inflammation of orbit
0.645 0.355 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.644 0.356 0.000
A49 Bacterial infection of unspecified site
0.644 0.356 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.644 0.356 0.000
S22.0 Fracture of thoracic vertebra
0.643 0.356 0.000
R65 Systemic Inflammatory Response Syndrome [SIRS]
0.643 0.357 0.000
R62 Lack of expected normal physiological development
0.643 0.357 0.000
R64 Cachexia
0.643 0.357 0.000
M22.4 Chondromalacia patellae
0.643 0.357 0.000
M06.9 Rheumatoid arthritis, unspecified
0.643 0.357 0.000
S01.3 Open wound of ear
0.643 0.357 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.642 0.358 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.642 0.358 0.000
K09 Cysts of oral region, not elsewhere classified
0.641 0.359 0.000
K03 Other diseases of hard tissues of teeth
0.641 0.359 0.000
K00 Disorders of tooth development and eruption
0.641 0.359 0.000
N11 Chronic tubulo-interstitial nephritis
0.640 0.359 0.000
K55.9 Vascular disorder of intestine, unspecified
0.640 0.360 0.000
R23 Other skin changes
0.640 0.360 0.000
S01.7 Multiple open wounds of head
0.638 0.361 0.000
S01.4 Open wound of cheek and temporomandibular area
0.638 0.361 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.638 0.361 0.000
O80 Single spontaneous delivery
0.638 0.362 0.000
M05.8 Other seropositive rheumatoid arthritis
0.638 0.362 0.000
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.638 0.362 0.000
M05.2 Rheumatoid vasculitis
0.638 0.362 0.000
M05.1 Rheumatoid lung disease
0.638 0.362 0.000
M05.0 Felty's syndrome
0.638 0.362 0.000
M20.4 Other hammer toe(s) (acquired)
0.638 0.362 0.000
K05 Gingivitis and periodontal diseases
0.637 0.362 0.000
A09.0 Other and unspecified gastroenteritis and colitis of infectious origin
0.637 0.363 0.000
I70 Atherosclerosis
0.637 0.363 0.000
H73 Other disorders of tympanic membrane
0.637 0.363 0.000
I71 Aortic aneurysm and dissection
0.636 0.364 0.000
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere
0.636 0.364 0.000
H70 Mastoiditis and related conditions
0.636 0.364 0.000
H69 Other disorders of Eustachian tube
0.636 0.364 0.000
H68 Eustachian salpingitis and obstruction
0.636 0.364 0.000
H67 Otitis media in diseases classified elsewhere
0.636 0.364 0.000
H59 Postprocedural disorders of eye and adnexa, not elsewhere classified
0.635 0.365 0.000
S29.8 Other specified injuries of thorax
0.634 0.366 0.000
S29.7 Multiple injuries of thorax
0.634 0.366 0.000
S29.0 Injury of muscle and tendon at thorax level
0.634 0.366 0.000
K86.0 Alcohol-induced chronic pancreatitis
0.633 0.367 0.000
D68 Other coagulation defects
0.633 0.367 0.000
N20.1 Calculus of ureter
0.633 0.367 0.000
I05 Rheumatic mitral valve diseases
0.633 0.367 0.000
R21 Rash and other nonspecific skin eruption
0.633 0.367 0.000
S06.0 Concussion
0.633 0.367 0.000
O42.9 Premature rupture of membranes, unspecified
0.632 0.368 0.000
O82 Single delivery by Caesarean section
0.632 0.368 0.000
D55-D59 Haemolytic anaemias
0.632 0.368 0.000
R46 Symptoms and signs involving appearance and behaviour
0.632 0.368 0.000
R43 Disturbances of smell and taste
0.632 0.368 0.000
R61 Hyperhidrosis
0.632 0.368 0.000
W08 Fall involving other furniture
0.632 0.368 0.000
M80 Osteoporosis with pathological fracture
0.631 0.369 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.631 0.369 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.630 0.370 0.000
A04 Other bacterial intestinal infections
0.629 0.371 0.000
W17 Other fall from one level to another
0.629 0.371 0.000
T90 Sequelae of injuries of head
0.628 0.371 0.000
H00 Hordeolum and chalazion
0.628 0.372 0.000
M65 Synovitis and tenosynovitis
0.628 0.372 0.000
B97 Viral agents as the cause of diseases classified to other chapters
0.628 0.372 0.000
D51 Vitamin B12 deficiency anaemia
0.628 0.372 0.000
S06.2 Diffuse brain injury
0.627 0.373 0.000
I42.6 Alcoholic cardiomyopathy
0.626 0.373 0.000
A46 Erysipelas
0.625 0.374 0.000
A87 Viral meningitis
0.625 0.375 0.000
D69 Purpura and other haemorrhagic conditions
0.625 0.375 0.000
K04.5 Chronic apical periodontitis
0.623 0.376 0.000
H90 Conductive and sensorineural hearing loss
0.623 0.377 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.623 0.377 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.623 0.377 0.000
Q35-Q37 Cleft lip and cleft palate
0.623 0.377 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.623 0.377 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.623 0.377 0.000
Q00-Q07 Congenital malformations of the nervous system
0.623 0.377 0.000
I21.2 Acute transmural myocardial infarction of other sites
0.622 0.378 0.000
S60-S69 Injuries to the wrist and hand
0.622 0.378 0.000
K66.8 Other specified disorders of peritoneum
0.622 0.378 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.622 0.378 0.000
K38 Other diseases of appendix
0.621 0.379 0.000
W20-W49 Exposure to inanimate mechanical forces
0.621 0.379 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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