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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs116517351
log Bayes Factor = 17.5697
Chromosome 2   position 20,160,078  (GRCh37) Explore rs116517351 on Ensembl!
Variant rs116517351 is part of Cluster X0045

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.999 0.001 0.000
Chapter II Neoplasms
0.999 0.001 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.999 0.001 0.000
Chapter IX Diseases of the circulatory system
0.998 0.002 0.000
Chapter XX External causes of morbidity and mortality
0.998 0.002 0.000
Chapter I Certain infectious and parasitic diseases
0.998 0.002 0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems
0.996 0.004 0.000
M20-M25 Other joint disorders
0.995 0.005 0.000
M05-M14 Inflammatory polyarthropathies
0.994 0.006 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.990 0.010 0.000
C60-C63 Malignant neoplasms of male genital organs
0.988 0.012 0.000
M06 Other rheumatoid arthritis
0.986 0.014 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.983 0.017 0.000
Chapter VI Diseases of the nervous system
0.981 0.019 0.000
C61 Malignant neoplasm of prostate
0.981 0.019 0.000
M06.9 Rheumatoid arthritis, unspecified
0.977 0.023 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.976 0.024 0.000
I30-I52 Other forms of heart disease
0.976 0.024 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.972 0.028 0.000
I51 Complications and ill-defined descriptions of heart disease
0.968 0.032 0.000
Chapter XXI Factors influencing health status and contact with health services
0.967 0.033 0.000
M20 Acquired deformities of fingers and toes
0.963 0.037 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.958 0.042 0.000
G40-G47 Episodic and paroxysmal disorders
0.956 0.044 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.949 0.051 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.948 0.052 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.947 0.053 0.000
A30-A49 Other bacterial diseases
0.946 0.054 0.000
A00-A09 Intestinal infectious diseases
0.940 0.060 0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.937 0.063 0.000
G47 Sleep disorders
0.936 0.064 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.933 0.067 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.933 0.067 0.000
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts
0.932 0.068 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.930 0.070 0.000
I27 Other pulmonary heart diseases
0.923 0.077 0.000
M23 Internal derangement of knee
0.919 0.081 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.918 0.082 0.000
I05-I09 Chronic rheumatic heart diseases
0.917 0.083 0.000
M50-M54 Other dorsopathies
0.916 0.084 0.000
M80-M85 Disorders of bone density and structure
0.915 0.084 0.000
R06 Abnormalities of breathing
0.915 0.085 0.000
I51.8 Other ill-defined heart diseases
0.914 0.086 0.000
Z30-Z39 Persons encountering health services in circumstances related to reproduction
0.913 0.087 0.000
R00 Abnormalities of heart beat
0.911 0.089 0.000
G47.3 Sleep apnoea
0.910 0.090 0.000
I51.7 Cardiomegaly
0.907 0.093 0.000
Z00-Z13 Persons encountering health services for examination and investigation
0.906 0.094 0.000
T81 Complications of procedures, not elsewhere classified
0.902 0.098 0.000
M20.1 Hallux valgus (acquired)
0.899 0.101 0.000
B25-B34 Other viral diseases
0.898 0.102 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.897 0.103 0.000
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts
0.895 0.105 0.000
R47-R49 Symptoms and signs involving speech and voice
0.892 0.108 0.000
G30-G32 Other degenerative diseases of the nervous system
0.889 0.111 0.000
B15-B19 Viral hepatitis
0.885 0.115 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.884 0.116 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.883 0.117 0.000
A09 Diarrhoea and gastro-enteritis of presumed infectious origin
0.880 0.120 0.000
Chapter V Mental and behavioural disorders
0.879 0.121 0.000
R29 Other symptoms and signs involving the nervous and musculoskeletal systems
0.879 0.121 0.000
B95-B98 Bacterial, viral and other infectious agents
0.878 0.122 0.000
T81.3 Disruption of operation wound, not elsewhere classified
0.877 0.123 0.000
I45 Other conduction disorders
0.876 0.124 0.000
M20.5 Other deformities of toe(s) (acquired)
0.875 0.125 0.000
M23.3 Other meniscus derangements
0.873 0.127 0.000
G45 Transient cerebral ischaemic attacks and related syndromes
0.870 0.130 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.867 0.133 0.000
M40-M43 Deforming dorsopathies
0.866 0.133 0.000
R02 Gangrene, not elsewhere classified
0.866 0.134 0.000
A41 Other septicaemia
0.864 0.136 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.864 0.136 0.000
Z01 Other special examinations and investigations of persons without complaint or reported diagnosis
0.864 0.136 0.000
S20-S29 Injuries to the thorax
0.862 0.138 0.000
I27.0 Primary pulmonary hypertension
0.862 0.138 0.000
C85.1 B-cell lymphoma, unspecified
0.862 0.138 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.859 0.141 0.000
T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
0.859 0.141 0.000
Z08 Follow-up examination after treatment for malignant neoplasm
0.856 0.144 0.000
R00.1 Bradycardia, unspecified
0.856 0.144 0.000
Z30 Contraceptive management
0.854 0.146 0.000
R09 Other symptoms and signs involving the circulatory and respiratory systems
0.851 0.149 0.000
T82.1 Mechanical complication of cardiac electronic device
0.851 0.149 0.000
M25 Other joint disorders, not elsewhere classified
0.850 0.150 0.000
O32 Maternal care for known or suspected malpresentation of foetus
0.849 0.151 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.848 0.152 0.000
C83 Diffuse non-Hodgkin's lymphoma
0.847 0.152 0.000
Y45.0 Opioids and related analgesics
0.842 0.158 0.000
Y83 Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.838 0.162 0.000
I51.9 Heart disease, unspecified
0.837 0.163 0.000
A09.9 Gastroenteritis and colitis of unspecified origin
0.837 0.163 0.000
I27.2 Other secondary pulmonary hypertension
0.835 0.165 0.000
M54 Dorsalgia
0.832 0.168 0.000
T82.3 Mechanical complication of other vascular grafts
0.832 0.168 0.000
R03 Abnormal blood-pressure reading, without diagnosis
0.830 0.170 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.828 0.172 0.000
B34 Viral infection of unspecified site
0.826 0.174 0.000
R47 Speech disturbances, not elsewhere classified
0.825 0.175 0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters
0.823 0.177 0.000
C15-C26 Malignant neoplasms of digestive organs
0.823 0.177 0.000
O30 Multiple gestation
0.821 0.179 0.000
I71 Aortic aneurysm and dissection
0.821 0.179 0.000
S40-S49 Injuries to the shoulder and upper arm
0.820 0.180 0.000
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.819 0.181 0.000
Z01.8 Other specified special examinations
0.812 0.188 0.000
Z30.5 Surveillance of (intra-uterine) contraceptive device
0.810 0.190 0.000
M31 Other necrotising vasculopathies
0.808 0.192 0.000
I35 Nonrheumatic aortic valve disorders
0.808 0.192 0.000
G45.9 Transient cerebral ischaemic attack, unspecified
0.807 0.193 0.000
I74 Arterial embolism and thrombosis
0.807 0.193 0.000
Z08.7 Follow-up examination after combined treatment for malignant neoplasm
0.807 0.193 0.000
R05 Cough
0.805 0.195 0.000
M13 Other arthritis
0.804 0.196 0.000
R00.0 Tachycardia, unspecified
0.801 0.199 0.000
Y84 Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.801 0.199 0.000
R29.6 Tendency to fall, not elsewhere classified
0.801 0.199 0.000
W20-W49 Exposure to inanimate mechanical forces
0.801 0.199 0.000
A04 Other bacterial intestinal infections
0.800 0.200 0.000
M06.0 Seronegative rheumatoid arthritis
0.799 0.201 0.000
C92 Myeloid leukaemia
0.799 0.201 0.000
I08 Multiple valve diseases
0.797 0.203 0.000
R06.4 Hyperventilation
0.797 0.203 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.796 0.203 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.794 0.206 0.000
O80-O84 Delivery
0.791 0.209 0.000
Y45.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.791 0.209 0.000
O42 Premature rupture of membranes
0.789 0.211 0.000
Chapter XIV Diseases of the genitourinary system
0.788 0.212 0.000
M07 Psoriatic and enteropathic arthropathies
0.787 0.213 0.000
O21 Excessive vomiting in pregnancy
0.786 0.214 0.000
O46 Antepartum haemorrhage, not elsewhere classified
0.784 0.216 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.784 0.216 0.000
M21 Other acquired deformities of limbs
0.784 0.216 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.783 0.217 0.000
I34 Nonrheumatic mitral valve disorders
0.782 0.218 0.000
C91 Lymphoid leukaemia
0.782 0.218 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.780 0.220 0.000
G47.9 Sleep disorder, unspecified
0.779 0.221 0.000
Y83.1 Surgical operation with implant of artificial internal device
0.779 0.221 0.000
G90-G99 Other disorders of the nervous system
0.779 0.221 0.000
M86-M90 Other osteopathies
0.778 0.222 0.000
F41 Other anxiety disorders
0.778 0.222 0.000
O32.1 Maternal care for breech presentation
0.777 0.223 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.777 0.223 0.000
M25.7 Osteophyte
0.776 0.224 0.000
Y44 Agents primarily affecting blood constituents
0.776 0.224 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.776 0.224 0.000
A41.9 Septicaemia, unspecified
0.776 0.224 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.776 0.224 0.000
T79-T79 Certain early complications of trauma
0.775 0.224 0.000
G30 Alzheimer's disease
0.775 0.225 0.000
R01 Cardiac murmurs and other cardiac sounds
0.775 0.225 0.000
W00-W19 Falls
0.770 0.230 0.000
M20.3 Other deformity of hallux (acquired)
0.769 0.231 0.000
R25 Abnormal involuntary movements
0.768 0.232 0.000
M80 Osteoporosis with pathological fracture
0.768 0.232 0.000
Y60 Unintentional cut, puncture, perforation or haemorrhage during surgical and medical care
0.767 0.233 0.000
M70-M79 Other soft tissue disorders
0.765 0.235 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.765 0.235 0.000
Z30.1 Insertion of (intra-uterine) contraceptive device
0.763 0.237 0.000
Y45.1 Salicylates
0.762 0.238 0.000
R29.8 Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
0.762 0.238 0.000
M05 Seropositive rheumatoid arthritis
0.761 0.239 0.000
N80-N98 Noninflammatory disorders of female genital tract
0.760 0.240 0.000
I33 Acute and subacute endocarditis
0.759 0.241 0.000
R21 Rash and other nonspecific skin eruption
0.759 0.241 0.000
T81.2 Accidental puncture and laceration during a procedure, not elsewhere classified
0.759 0.241 0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases
0.758 0.242 0.000
M43 Other deforming dorsopathies
0.757 0.243 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.755 0.244 0.000
S90-S99 Injuries to the ankle and foot
0.755 0.245 0.000
T86 Failure and rejection of transplanted organs and tissues
0.754 0.246 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.754 0.246 0.000
I45.1 Other and unspecified right bundle-branch block
0.753 0.247 0.000
B18 Chronic viral hepatitis
0.752 0.248 0.000
I77 Other disorders of arteries and arterioles
0.751 0.249 0.000
C83.3 Large cell (diffuse)
0.750 0.250 0.000
M23.8 Other internal derangements of knee
0.749 0.251 0.000
Y43 Primarily systemic agents
0.749 0.251 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.748 0.252 0.000
M84 Disorders of continuity of bone
0.748 0.252 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.747 0.253 0.000
A40 Streptococcal septicaemia
0.747 0.253 0.000
B34.9 Viral infection, unspecified
0.746 0.254 0.000
M24 Other specific joint derangements
0.746 0.254 0.000
A80-A89 Viral infections of the central nervous system
0.744 0.256 0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.744 0.256 0.000
C43-C44 Melanoma and other malignant neoplasms of skin
0.744 0.256 0.000
M34 Systemic sclerosis
0.744 0.256 0.000
A49 Bacterial infection of unspecified site
0.744 0.256 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.743 0.257 0.000
M22 Disorders of patella
0.742 0.258 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.742 0.258 0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis
0.742 0.258 0.000
M23.33 Other meniscus derangements (Medial collateral ligament or Other and unspecified medial meniscus)
0.741 0.259 0.000
I07 Rheumatic tricuspid valve diseases
0.741 0.259 0.000
D70 Agranulocytosis
0.741 0.259 0.000
T66-T78 Other and unspecified effects of external causes
0.740 0.260 0.000
T84.0 Mechanical complication of internal joint prosthesis
0.739 0.261 0.000
R06.2 Wheezing
0.739 0.261 0.000
Z31 Procreative management
0.737 0.263 0.000
I30 Acute pericarditis
0.736 0.264 0.000
Z36 Antenatal screening
0.736 0.264 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.734 0.266 0.000
O34 Maternal care for known or suspected abnormality of pelvic organs
0.734 0.266 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.733 0.267 0.000
B95.3 Streptococcus pneumoniae as the cause of diseases classified to other chapters
0.733 0.267 0.000
O23 Infections of genito-urinary tract in pregnancy
0.733 0.267 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.732 0.268 0.000
Y83.2 Surgical operation with anastomosis, bypass or graft
0.732 0.268 0.000
Y57 Other and unspecified drugs and medicaments
0.732 0.268 0.000
B17 Other acute viral hepatitis
0.731 0.269 0.000
I35.1 Aortic (valve) insufficiency
0.731 0.269 0.000
R47.0 Dysphasia and aphasia
0.731 0.269 0.000
I45.5 Other specified heart block
0.730 0.270 0.000
I05 Rheumatic mitral valve diseases
0.730 0.270 0.000
O30.0 Twin pregnancy
0.729 0.271 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.728 0.272 0.000
O47 False labour
0.728 0.272 0.000
A46 Erysipelas
0.728 0.272 0.000
M91-M94 Chondropathies
0.726 0.273 0.000
Z33 Pregnant state, incidental
0.725 0.275 0.000
M50 Cervical disk disorders
0.725 0.275 0.000
V20-V29 Motorcycle rider injured in transport accident
0.725 0.275 0.000
S70-S79 Injuries to the hip and thigh
0.725 0.275 0.000
A04.7 Enterocolitis due to Clostridium difficile
0.723 0.277 0.000
I78 Diseases of capillaries
0.722 0.278 0.000
Y40 Systemic antibiotics
0.722 0.278 0.000
M23.34 Other meniscus derangements (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.717 0.282 0.000
C48 Malignant neoplasm of retroperitoneum and peritoneum
0.717 0.283 0.000
M60-M63 Disorders of muscles
0.717 0.283 0.000
M00-M03 Infectious arthropathies
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.717 0.283 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.717 0.283 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
S10-S19 Injuries to the neck
0.717 0.283 0.000
T87 Complications peculiar to reattachment and amputation
0.716 0.283 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.716 0.284 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.716 0.284 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.716 0.284 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.716 0.284 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.716 0.284 0.000
I00-I02 Acute rheumatic fever
0.716 0.284 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.716 0.284 0.000
Y35-Y36 Legal intervention and operations of war
0.716 0.284 0.000
Y10-Y34 Event of undetermined intent
0.716 0.284 0.000
Y00-Y09 Assault
0.716 0.284 0.000
X85-X99 Assault
0.716 0.284 0.000
X60-X84 Intentional self-harm
0.716 0.284 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.716 0.284 0.000
X50-X57 Overexertion, travel and privation
0.716 0.284 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.716 0.284 0.000
X30-X39 Exposure to forces of nature
0.716 0.284 0.000
X20-X29 Contact with venomous animals and plants
0.716 0.284 0.000
X10-X19 Contact with heat and hot substances
0.716 0.284 0.000
X00-X09 Exposure to smoke, fire and flames
0.716 0.284 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.716 0.284 0.000
W75-W84 Other accidental threats to breathing
0.716 0.284 0.000
W65-W74 Accidental drowning and submersion
0.716 0.284 0.000
W50-W64 Exposure to animate mechanical forces
0.716 0.284 0.000
V98-V99 Other and unspecified transport accidents
0.716 0.284 0.000
V95-V97 Air and space transport accidents
0.716 0.284 0.000
V90-V94 Water transport accidents
0.716 0.284 0.000
V80-V89 Other land transport accidents
0.716 0.284 0.000
V70-V79 Bus occupant injured in transport accident
0.716 0.284 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.716 0.284 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.716 0.284 0.000
V40-V49 Car occupant injured in transport accident
0.716 0.284 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.716 0.284 0.000
V01-V09 Pedestrian injured in transport accident
0.716 0.284 0.000
B99-B99 Other infectious diseases
0.716 0.284 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.716 0.284 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.716 0.284 0.000
B65-B83 Helminthiases
0.716 0.284 0.000
B50-B64 Protozoal diseases
0.716 0.284 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.716 0.284 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.716 0.284 0.000
A75-A79 Rickettsioses
0.716 0.284 0.000
A70-A74 Other diseases caused by chlamydiae
0.716 0.284 0.000
A65-A69 Other spirochaetal diseases
0.716 0.284 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.716 0.284 0.000
A20-A28 Certain zoonotic bacterial diseases
0.716 0.284 0.000
A15-A19 Tuberculosis
0.716 0.284 0.000
Chapter VII Diseases of the eye and adnexa
0.714 0.286 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.714 0.286 0.000
M33 Dermatopolymyositis
0.714 0.286 0.000
M32 Systemic lupus erythematosus
0.714 0.286 0.000
M30 Polyarteritis nodosa and related conditions
0.714 0.286 0.000
M14 Arthropathies in other diseases classified elsewhere
0.713 0.287 0.000
M12 Other specific arthropathies
0.713 0.287 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.713 0.287 0.000
M08 Juvenile arthritis
0.713 0.287 0.000
I73 Other peripheral vascular diseases
0.712 0.288 0.000
N93 Other abnormal uterine and vaginal bleeding
0.712 0.288 0.000
Z11 Special screening examination for infectious and parasitic diseases
0.711 0.289 0.000
C45 Mesothelioma
0.711 0.289 0.000
I27.9 Pulmonary heart disease, unspecified
0.710 0.290 0.000
T82.9 Unspecified complication of cardiac and vascular prosthetic device, implant and graft
0.710 0.290 0.000
T82.6 Infection and inflammatory reaction due to cardiac valve prosthesis
0.710 0.290 0.000
T82.4 Mechanical complication of vascular dialysis catheter
0.710 0.290 0.000
T82.2 Mechanical complication of coronary artery bypass and valve grafts
0.710 0.290 0.000
T82.0 Mechanical complication of heart valve prosthesis
0.710 0.290 0.000
M82 Osteoporosis in diseases classified elsewhere
0.710 0.290 0.000
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.710 0.290 0.000
M81 Osteoporosis without pathological fracture
0.709 0.291 0.000
C63 Malignant neoplasm of other and unspecified male genital organs
0.709 0.291 0.000
C62 Malignant neoplasm of testis
0.709 0.291 0.000
C60 Malignant neoplasm of penis
0.709 0.291 0.000
M25.77 Osteophyte (Ankle and foot)
0.708 0.292 0.000
S29 Other and unspecified injuries of thorax
0.708 0.292 0.000
M06.8 Other specified rheumatoid arthritis
0.707 0.293 0.000
M06.4 Inflammatory polyarthropathy
0.707 0.293 0.000
M06.3 Rheumatoid nodule
0.707 0.293 0.000
M06.2 Rheumatoid bursitis
0.707 0.293 0.000
M06.1 Adult-onset Still's disease
0.707 0.293 0.000
Chapter XXII Codes for special purposes
0.707 0.293 0.000
I08.1 Disorders of both mitral and tricuspid valves
0.706 0.294 0.000
M23.30 Other meniscus derangements (Multiple sites)
0.706 0.294 0.000
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.705 0.295 0.000
C95 Leukaemia of unspecified cell type
0.705 0.295 0.000
C94 Other leukaemias of specified cell type
0.705 0.295 0.000
C93 Monocytic leukaemia
0.705 0.295 0.000
C88 Malignant immunoproliferative diseases
0.705 0.295 0.000
C86 Other specified types of T/NK-cell lymphoma
0.705 0.295 0.000
C84 Peripheral and cutaneous T-cell lymphomas
0.705 0.295 0.000
C81 Hodgkin's disease
0.705 0.295 0.000
I72 Other aneurysm
0.705 0.295 0.000
M54.4 Lumbago with sciatica
0.704 0.296 0.000
G70-G73 Diseases of myoneural junction and muscle
0.703 0.297 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.703 0.297 0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.703 0.297 0.000
M20.6 Acquired deformity of toe(s), unspecified
0.703 0.297 0.000
R06.5 Mouth breathing
0.703 0.297 0.000
M06.98 Rheumatoid arthritis, unspecified (Other)
0.700 0.299 0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.700 0.299 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.700 0.299 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.700 0.299 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.700 0.299 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.700 0.299 0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.700 0.299 0.000
Y59 Other and unspecified vaccines and biological substances
0.700 0.300 0.000
Y58 Bacterial vaccines
0.700 0.300 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.700 0.300 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.700 0.300 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.700 0.300 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.700 0.300 0.000
Y52 Agents primarily affecting the cardiovascular system
0.700 0.300 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.700 0.300 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.700 0.300 0.000
Y48 Anaesthetics and therapeutic gases
0.700 0.300 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.700 0.300 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.700 0.300 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.700 0.300 0.000
A41.0 Septicaemia due to Staphylococcus aureus
0.700 0.300 0.000
I52 Other heart disorders in diseases classified elsewhere
0.700 0.300 0.000
I48 Atrial fibrillation and flutter
0.700 0.300 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.700 0.300 0.000
I41 Myocarditis in diseases classified elsewhere
0.700 0.300 0.000
I40 Acute myocarditis
0.700 0.300 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.700 0.300 0.000
I37 Pulmonary valve disorders
0.700 0.300 0.000
I36 Nonrheumatic tricuspid valve disorders
0.700 0.300 0.000
I32 Pericarditis in diseases classified elsewhere
0.700 0.300 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.699 0.301 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.699 0.301 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.698 0.301 0.000
Y60.0 During surgical operation
0.698 0.302 0.000
F41.9 Anxiety disorder, unspecified
0.698 0.302 0.000
S50-S59 Injuries to the elbow and forearm
0.698 0.302 0.000
Z00 General examination and investigation of persons without complaint or reported diagnosis
0.698 0.302 0.000
O85-O92 Complications predominantly related to the puerperium
0.697 0.303 0.000
M54.5 Low back pain
0.696 0.304 0.000
R47.8 Other and unspecified speech disturbances
0.696 0.304 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.694 0.305 0.000
I51.6 Cardiovascular disease, unspecified
0.694 0.306 0.000
I51.5 Myocardial degeneration
0.694 0.306 0.000
I51.4 Myocarditis, unspecified
0.694 0.306 0.000
I51.3 Intracardiac thrombosis, not elsewhere classified
0.694 0.306 0.000
I51.2 Rupture of papillary muscle, not elsewhere classified
0.694 0.306 0.000
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.694 0.306 0.000
I51.0 Cardiac septal defect, acquired
0.694 0.306 0.000
V10-V19 Pedal cyclist injured in transport accident
0.693 0.307 0.000
I60-I69 Cerebrovascular diseases
0.693 0.307 0.000
G30.9 Alzheimer's disease, unspecified
0.693 0.307 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.693 0.307 0.000
M23.39 Other meniscus derangements (Unspecified ligament or Unspecified meniscus)
0.692 0.308 0.000
Z39 Postpartum care and examination
0.692 0.308 0.000
S22 Fracture of rib(s), sternum and thoracic spine
0.691 0.309 0.000
M23.4 Loose body in knee
0.690 0.310 0.000
T85.5 Mechanical complication of gastro-intestinal prosthetic devices, implants and grafts
0.690 0.310 0.000
M10 Gout
0.688 0.312 0.000
Z08.2 Follow-up examination after chemotherapy for malignant neoplasm
0.687 0.313 0.000
G44 Other headache syndromes
0.686 0.314 0.000
G46 Vascular syndromes of brain in cerebrovascular diseases
0.686 0.314 0.000
G41 Status epilepticus
0.686 0.314 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.685 0.315 0.000
C90 Multiple myeloma and malignant plasma cell neoplasms
0.684 0.316 0.000
Z40-Z54 Persons encountering health services for specific procedures and health care
0.684 0.316 0.000
T85.6 Mechanical complication of other specified internal prosthetic devices, implants and grafts
0.683 0.316 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.683 0.317 0.000
R22 Localised swelling, mass and lump of skin and subcutaneous tissue
0.683 0.317 0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.682 0.317 0.000
R10-R19 Symptoms and signs involving the digestive system and abdomen
0.682 0.318 0.000
F80-F89 Disorders of psychological development
0.682 0.318 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.681 0.319 0.000
O45 Premature separation of placenta [abruptio placentae]
0.680 0.320 0.000
O44 Placenta praevia
0.680 0.320 0.000
O43 Placental disorders
0.680 0.320 0.000
O41 Other disorders of amniotic fluid and membranes
0.680 0.320 0.000
O35 Maternal care for known or suspected foetal abnormality and damage
0.680 0.320 0.000
O33 Maternal care for known or suspected disproportion
0.680 0.320 0.000
O31 Complications specific to multiple gestation
0.680 0.320 0.000
O40 Polyhydramnios
0.680 0.320 0.000
R06.8 Other and unspecified abnormalities of breathing
0.680 0.320 0.000
Z08.8 Follow-up examination after other treatment for malignant neoplasm
0.680 0.320 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.680 0.320 0.000
N86 Erosion and ectropion of cervix uteri
0.680 0.320 0.000
N92 Excessive, frequent and irregular menstruation
0.680 0.320 0.000
R04 Haemorrhage from respiratory passages
0.680 0.320 0.000
C18 Malignant neoplasm of colon
0.679 0.321 0.000
M43.1 Spondylolisthesis
0.679 0.321 0.000
I34.0 Mitral (valve) insufficiency
0.679 0.321 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.679 0.321 0.000
I28 Other diseases of pulmonary vessels
0.679 0.321 0.000
B95.4 Other streptococcus as the cause of diseases classified to other chapters
0.678 0.322 0.000
A48 Other bacterial diseases, not elsewhere classified
0.678 0.322 0.000
A44 Bartonellosis
0.678 0.322 0.000
A43 Nocardiosis
0.678 0.322 0.000
A42 Actinomycosis
0.678 0.322 0.000
A39 Meningococcal infection
0.678 0.322 0.000
A37 Whooping cough
0.678 0.322 0.000
A36 Diphtheria
0.678 0.322 0.000
A32 Listeriosis
0.678 0.322 0.000
A31 Infection due to other mycobacteria
0.678 0.322 0.000
A30 Leprosy [Hansen's disease]
0.678 0.322 0.000
A38 Scarlet fever
0.678 0.322 0.000
A35 Other tetanus
0.678 0.322 0.000
A34 Obstetrical tetanus
0.678 0.322 0.000
A33 Tetanus neonatorum
0.678 0.322 0.000
F41.2 Mixed anxiety and depressive disorder
0.678 0.322 0.000
R09.2 Respiratory arrest
0.677 0.323 0.000
T85.2 Mechanical complication of intraocular lens
0.676 0.324 0.000
B34.8 Other viral infections of unspecified site
0.676 0.324 0.000
M20.2 Hallux rigidus
0.676 0.324 0.000
O26 Maternal care for other conditions predominantly related to pregnancy
0.675 0.325 0.000
N83 Noninflammatory disorders of ovary, Fallopian tube and broad ligament
0.675 0.325 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.674 0.326 0.000
M31.6 Other giant cell arteritis
0.674 0.326 0.000
A07 Other protozoal intestinal diseases
0.674 0.326 0.000
A06 Amoebiasis
0.674 0.326 0.000
A05 Other bacterial foodborne intoxications
0.674 0.326 0.000
A03 Shigellosis
0.674 0.326 0.000
A02 Other Salmonella infections
0.674 0.326 0.000
A01 Typhoid and paratyphoid fevers
0.674 0.326 0.000
A00 Cholera
0.674 0.326 0.000
M11 Other crystal arthropathies
0.672 0.328 0.000
W25 Contact with sharp glass
0.672 0.328 0.000
C85.7 Other specified types of non-Hodgkin's lymphoma
0.671 0.328 0.000
C85.2 Mediastinal (thymic) large B-cell lymphoma
0.671 0.328 0.000
C85.0 Lymphosarcoma
0.671 0.328 0.000
M23.36 Other meniscus derangements (Other and unspecified lateral meniscus)
0.671 0.329 0.000
G47.8 Other sleep disorders
0.671 0.329 0.000
G47.4 Narcolepsy and cataplexy
0.671 0.329 0.000
G47.2 Disorders of the sleep-wake schedule
0.671 0.329 0.000
G47.1 Disorders of excessive somnolence [hypersomnias]
0.671 0.329 0.000
G47.0 Disorders of initiating and maintaining sleep [insomnias]
0.671 0.329 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.671 0.329 0.000
Y45.9 Analgesic, antipyretic and anti-inflammatory drug, unspecified
0.669 0.331 0.000
Y45.8 Other analgesics and antipyretics
0.669 0.331 0.000
Y45.5 4-Aminophenol derivatives
0.669 0.331 0.000
Y45.4 Antirheumatics
0.669 0.331 0.000
Y45.2 Propionic acid derivatives
0.669 0.331 0.000
T82.5 Mechanical complication of other cardiac and vascular devices and implants
0.668 0.331 0.000
C16 Malignant neoplasm of stomach
0.669 0.331 0.000
R07 Pain in throat and chest
0.668 0.332 0.000
R10 Abdominal and pelvic pain
0.668 0.332 0.000
M13.9 Arthritis, unspecified
0.668 0.332 0.000
Z01.4 Gynaecological examination (general)(routine)
0.668 0.332 0.000
O24 Diabetes mellitus in pregnancy
0.668 0.332 0.000
C64-C68 Malignant neoplasms of urinary tract
0.668 0.332 0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.667 0.333 0.000
N94 Pain and other conditions associated with female genital organs and menstrual cycle
0.667 0.333 0.000
C92.0 Acute myeloid leukaemia
0.667 0.333 0.000
R25.2 Cramp and spasm
0.667 0.333 0.000
Z70-Z76 Persons encountering health services in other circumstances
0.666 0.334 0.000
O46.9 Antepartum haemorrhage, unspecified
0.666 0.334 0.000
A41.8 Other specified septicaemia
0.666 0.334 0.000
B95.6 Staphylococcus aureus as the cause of diseases classified to other chapters
0.665 0.335 0.000
R06.0 Dyspnoea
0.665 0.335 0.000
O21.1 Hyperemesis gravidarum with metabolic disturbance
0.665 0.335 0.000
R23 Other skin changes
0.664 0.336 0.000
R03.0 Elevated blood-pressure reading, without diagnosis of hypertension
0.663 0.337 0.000
M80.9 Unspecified osteoporosis with pathological fracture
0.663 0.337 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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