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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs12127701
log Bayes Factor = 14.0237
Chromosome 1   position 109,838,264  (GRCh37) Explore rs12127701 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E78.0 Pure hypercholesterolaemia
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
Chapter IX Diseases of the circulatory system
0.000 0.000 1.000
I30-I52 Other forms of heart disease
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.000 1.000
I50 Heart failure
0.000 0.001 0.999
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.001 0.999
I50.0 Congestive heart failure
0.000 0.005 0.995
I20 Angina pectoris
0.000 0.011 0.989
I73 Other peripheral vascular diseases
0.000 0.017 0.983
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.018 0.982
I73.9 Peripheral vascular disease, unspecified
0.000 0.020 0.980
I74 Arterial embolism and thrombosis
0.000 0.021 0.979
I10-I15 Hypertensive diseases
0.000 0.022 0.978
I25.2 Old myocardial infarction
0.000 0.030 0.970
I20.0 Unstable angina
0.000 0.042 0.958
I50.9 Heart failure, unspecified
0.000 0.043 0.957
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.000 0.044 0.956
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.046 0.954
I20.9 Angina pectoris, unspecified
0.000 0.047 0.953
E78.5 Hyperlipidaemia, unspecified
0.000 0.054 0.946
I10 Essential (primary) hypertension
0.000 0.060 0.940
I35 Nonrheumatic aortic valve disorders
0.000 0.064 0.936
I35.0 Aortic (valve) stenosis
0.000 0.071 0.929
I77 Other disorders of arteries and arterioles
0.000 0.095 0.905
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.110 0.890
I71 Aortic aneurysm and dissection
0.000 0.113 0.887
I12 Hypertensive renal disease
0.000 0.115 0.885
I50.1 Left ventricular failure
0.000 0.130 0.870
I47 Paroxysmal tachycardia
0.000 0.134 0.866
I25.3 Aneurysm of heart
0.000 0.151 0.848
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.162 0.838
I47.1 Supraventricular tachycardia
0.000 0.170 0.830
I42 Cardiomyopathy
0.000 0.187 0.813
I05-I09 Chronic rheumatic heart diseases
0.000 0.189 0.811
I21 Acute myocardial infarction
0.000 0.205 0.795
I38 Endocarditis, valve unspecified
0.000 0.206 0.794
I74.5 Embolism and thrombosis of iliac artery
0.000 0.228 0.772
I12.9 Hypertensive renal disease without renal failure
0.000 0.230 0.770
I46 Cardiac arrest
0.000 0.237 0.763
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.238 0.762
I33 Acute and subacute endocarditis
0.000 0.238 0.762
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.000 0.245 0.755
I77.6 Arteritis, unspecified
0.000 0.250 0.750
I77.8 Other specified disorders of arteries and arterioles
0.000 0.251 0.749
I49 Other cardiac arrhythmias
0.000 0.259 0.741
I12.0 Hypertensive renal disease with renal failure
0.000 0.259 0.741
I21.4 Acute subendocardial myocardial infarction
0.000 0.265 0.735
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.000 0.271 0.729
I51 Complications and ill-defined descriptions of heart disease
0.000 0.277 0.723
I42.9 Cardiomyopathy, unspecified
0.000 0.278 0.722
I36 Nonrheumatic tricuspid valve disorders
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.283 0.717
I00-I02 Acute rheumatic fever
0.000 0.283 0.717
I52 Other heart disorders in diseases classified elsewhere
0.000 0.283 0.717
I48 Atrial fibrillation and flutter
0.000 0.283 0.717
I43 Cardiomyopathy in diseases classified elsewhere
0.000 0.283 0.717
I41 Myocarditis in diseases classified elsewhere
0.000 0.283 0.717
I40 Acute myocarditis
0.000 0.283 0.717
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.000 0.283 0.717
I32 Pericarditis in diseases classified elsewhere
0.000 0.283 0.717
I77.1 Stricture of artery
0.000 0.284 0.716
I71.3 Abdominal aortic aneurysm, ruptured
0.000 0.284 0.716
I74.9 Embolism and thrombosis of unspecified artery
0.000 0.285 0.714
I25.4 Coronary artery aneurysm
0.000 0.286 0.713
I73.8 Other specified peripheral vascular diseases
0.000 0.295 0.705
I73.1 Thromboangiitis obliterans [Buerger]
0.000 0.295 0.705
I74.8 Embolism and thrombosis of other arteries
0.000 0.296 0.704
I37 Pulmonary valve disorders
0.000 0.297 0.703
I25.5 Ischaemic cardiomyopathy
0.000 0.297 0.702
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.000 0.298 0.702
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.000 0.298 0.702
I74.0 Embolism and thrombosis of abdominal aorta
0.000 0.298 0.702
I13 Hypertensive heart and renal disease
0.000 0.299 0.701
I35.8 Other aortic valve disorders
0.000 0.311 0.689
I23 Certain current complications following acute myocardial infarction
0.000 0.312 0.688
E78.6 Lipoprotein deficiency
0.000 0.316 0.684
E78.3 Hyperchylomicronaemia
0.000 0.316 0.684
E78.1 Pure hyperglyceridaemia
0.000 0.316 0.684
I42.8 Other cardiomyopathies
0.000 0.318 0.682
I15 Secondary hypertension
0.000 0.320 0.680
I31 Other diseases of pericardium
0.000 0.321 0.679
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.322 0.678
I71.0 Dissection of aorta [any part]
0.000 0.324 0.676
I07 Rheumatic tricuspid valve diseases
0.000 0.328 0.672
I77.0 Arteriovenous fistula, acquired
0.000 0.332 0.668
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.000 0.334 0.666
I49.8 Other specified cardiac arrhythmias
0.000 0.335 0.665
I20.1 Angina pectoris with documented spasm
0.000 0.336 0.664
I11 Hypertensive heart disease
0.000 0.336 0.664
I05 Rheumatic mitral valve diseases
0.000 0.345 0.655
I45 Other conduction disorders
0.000 0.351 0.649
I77.5 Necrosis of artery
0.000 0.351 0.649
I77.4 Coeliac artery compression syndrome
0.000 0.351 0.649
I77.3 Arterial fibromuscular dysplasia
0.000 0.351 0.649
I77.2 Rupture of artery
0.000 0.351 0.649
I24 Other acute ischaemic heart diseases
0.000 0.353 0.647
I46.0 Cardiac arrest with successful resuscitation
0.000 0.355 0.644
E78.4 Other hyperlipidaemia
0.000 0.357 0.642
I77.9 Disorder of arteries and arterioles, unspecified
0.000 0.362 0.638
I71.8 Aortic aneurysm of unspecified site, ruptured
0.000 0.364 0.636
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.000 0.364 0.636
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.000 0.364 0.636
I71.1 Thoracic aortic aneurysm, ruptured
0.000 0.364 0.636
I51.7 Cardiomegaly
0.000 0.377 0.623
I42.2 Other hypertrophic cardiomyopathy
0.000 0.381 0.619
I72 Other aneurysm
0.000 0.400 0.600
E78.8 Other disorders of lipoprotein metabolism
0.000 0.405 0.595
I49.0 Ventricular fibrillation and flutter
0.000 0.405 0.595
I45.1 Other and unspecified right bundle-branch block
0.000 0.405 0.595
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.000 0.408 0.592
I33.0 Acute and subacute infective endocarditis
0.000 0.408 0.592
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.000 0.414 0.586
I42.7 Cardiomyopathy due to drugs and other external agents
0.000 0.417 0.583
I42.5 Other restrictive cardiomyopathy
0.000 0.417 0.583
I42.4 Endocardial fibroelastosis
0.000 0.417 0.583
I42.3 Endomyocardial (eosinophilic) disease
0.000 0.417 0.583
I35.9 Aortic valve disorder, unspecified
0.000 0.418 0.582
I09 Other rheumatic heart diseases
0.000 0.418 0.581
I06 Rheumatic aortic valve diseases
0.000 0.418 0.581
I07.1 Tricuspid insufficiency
0.000 0.427 0.573
I51.8 Other ill-defined heart diseases
0.000 0.428 0.572
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.430 0.570
I47.0 Reentry ventricular arrhythmia
0.000 0.433 0.567
I78 Diseases of capillaries
0.000 0.434 0.566
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.000 0.436 0.564
I47.9 Paroxysmal tachycardia, unspecified
0.000 0.439 0.561
I49.5 Sick sinus syndrome
0.000 0.441 0.559
I05.9 Mitral valve disease, unspecified
0.000 0.443 0.557
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.447 0.553
I49.1 Atrial premature depolarisation
0.000 0.451 0.549
I46.1 Sudden cardiac death, so described
0.000 0.453 0.547
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.453 0.546
I79.1 Aortitis in diseases classified elsewhere
0.000 0.453 0.546
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.000 0.453 0.546
I33.9 Acute endocarditis, unspecified
0.000 0.453 0.546
I42.6 Alcoholic cardiomyopathy
0.000 0.456 0.544
I51.6 Cardiovascular disease, unspecified
0.000 0.456 0.544
I22 Subsequent myocardial infarction
0.000 0.458 0.542
I49.2 Junctional premature depolarisation
0.000 0.468 0.532
I42.1 Obstructive hypertrophic cardiomyopathy
0.000 0.472 0.528
I24.8 Other forms of acute ischaemic heart disease
0.000 0.479 0.521
I51.0 Cardiac septal defect, acquired
0.000 0.479 0.521
I51.5 Myocardial degeneration
0.000 0.481 0.518
I51.2 Rupture of papillary muscle, not elsewhere classified
0.000 0.481 0.518
I36.1 Nonrheumatic tricuspid (valve) insufficiency
0.000 0.485 0.515
I36.9 Nonrheumatic tricuspid valve disorder, unspecified
0.000 0.486 0.514
I36.8 Other nonrheumatic tricuspid valve disorders
0.000 0.486 0.514
I36.2 Nonrheumatic tricuspid (valve) stenosis with insufficiency
0.000 0.486 0.514
I36.0 Nonrheumatic tricuspid (valve) stenosis
0.000 0.486 0.514
I02 Rheumatic chorea
0.000 0.486 0.514
I01 Rheumatic fever with heart involvement
0.000 0.486 0.514
I00 Rheumatic fever without mention of heart involvement
0.000 0.486 0.514
I32.8 Pericarditis in other diseases classified elsewhere
0.000 0.486 0.514
I32.1 Pericarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.486 0.514
I32.0 Pericarditis in bacterial diseases classified elsewhere
0.000 0.486 0.514
I39.8 Endocarditis, valve unspecified, in diseases classified elsewhere
0.000 0.486 0.514
I39.4 Multiple valve disorders in diseases classified elsewhere
0.000 0.486 0.514
I39.3 Pulmonary valve disorders in diseases classified elsewhere
0.000 0.486 0.514
I39.2 Tricuspid valve disorders in diseases classified elsewhere
0.000 0.486 0.514
I39.1 Aortic valve disorders in diseases classified elsewhere
0.000 0.486 0.514
I39.0 Mitral valve disorders in diseases classified elsewhere
0.000 0.486 0.514
I40.9 Acute myocarditis, unspecified
0.000 0.486 0.514
I40.8 Other acute myocarditis
0.000 0.486 0.514
I40.1 Isolated myocarditis
0.000 0.486 0.514
I40.0 Infective myocarditis
0.000 0.486 0.514
I41.8 Myocarditis in other diseases classified elsewhere
0.000 0.486 0.514
I41.2 Myocarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.486 0.514
I41.1 Myocarditis in viral diseases classified elsewhere
0.000 0.486 0.514
I41.0 Myocarditis in bacterial diseases classified elsewhere
0.000 0.486 0.514
I43.8 Cardiomyopathy in other diseases classified elsewhere
0.000 0.486 0.514
I43.2 Cardiomyopathy in nutritional diseases
0.000 0.486 0.514
I43.1 Cardiomyopathy in metabolic diseases
0.000 0.486 0.514
I43.0 Cardiomyopathy in infectious and parasitic diseases classified elsewhere
0.000 0.486 0.514
I48.9 Atrial fibrillation and atrial flutter, unspecified
0.000 0.486 0.514
I48.4 Atypical atrial flutter
0.000 0.486 0.514
I48.3 Typical atrial flutter
0.000 0.486 0.514
I48.2 Chronic atrial fibrillation
0.000 0.486 0.514
I48.1 Persistent atrial fibrillation
0.000 0.486 0.514
I48.0 Paroxysmal atrial fibrillation
0.000 0.486 0.514
I52.8 Other heart disorders in other diseases classified elsewhere
0.000 0.486 0.514
I52.1 Other heart disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.486 0.514
I52.0 Other heart disorders in bacterial diseases classified elsewhere
0.000 0.486 0.514
I37.9 Pulmonary valve disorder, unspecified
0.000 0.496 0.504
I37.8 Other pulmonary valve disorders
0.000 0.496 0.504
I37.2 Pulmonary valve stenosis with insufficiency
0.000 0.496 0.504
I37.0 Pulmonary valve stenosis
0.000 0.496 0.504
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.497 0.503
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.497 0.503
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.497 0.503
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.497 0.503
I51.3 Intracardiac thrombosis, not elsewhere classified
0.000 0.500 0.500
I31.3 Pericardial effusion (noninflammatory)
0.000 0.500 0.500
I05.2 Mitral stenosis with insufficiency
0.000 0.501 0.499
I70 Atherosclerosis
0.001 0.505 0.494
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.507 0.493
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.507 0.493
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.507 0.493
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.507 0.493
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.507 0.493
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.507 0.493
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.507 0.493
I49.3 Ventricular premature depolarisation
0.000 0.509 0.491
I37.1 Pulmonary valve insufficiency
0.000 0.510 0.490
E78.2 Mixed hyperlipidaemia
0.000 0.512 0.488
I20.8 Other forms of angina pectoris
0.000 0.512 0.488
I15.9 Seconday hypertension, unspecified
0.000 0.512 0.488
I15.8 Other secondary hypertension
0.000 0.512 0.488
I15.2 Hypertension secondary to endocrine disorders
0.000 0.512 0.488
I15.0 Renovascular hypertension
0.000 0.512 0.488
I31.8 Other specified diseases of pericardium
0.000 0.513 0.487
I31.2 Haemopericardium, not elsewhere classified
0.000 0.513 0.487
I31.1 Chronic constrictive pericarditis
0.000 0.513 0.487
I31.0 Chronic adhesive pericarditis
0.000 0.513 0.487
I07.9 Tricuspid valve disease, unspecified
0.000 0.518 0.482
I07.8 Other tricuspid valve diseases
0.000 0.518 0.482
I07.2 Tricuspid stenosis with insufficiency
0.000 0.518 0.482
I07.0 Tricuspid stenosis
0.000 0.518 0.482
I08 Multiple valve diseases
0.000 0.518 0.482
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.000 0.520 0.480
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.524 0.476
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.526 0.474
I30 Acute pericarditis
0.001 0.529 0.470
I05.8 Other mitral valve diseases
0.000 0.530 0.470
I05.1 Rheumatic mitral insufficiency
0.000 0.530 0.470
I15.1 Hypertension secondary to other renal disorders
0.000 0.533 0.466
I45.8 Other specified conduction disorders
0.000 0.534 0.465
I45.3 Trifascicular block
0.000 0.534 0.465
I45.0 Right fascicular block
0.000 0.534 0.465
I23.8 Other current complications following acute myocardial infarction
0.000 0.536 0.464
I24.1 Dressler's syndrome
0.000 0.536 0.464
I45.5 Other specified heart block
0.000 0.540 0.460
I46.9 Cardiac arrest, unspecified
0.000 0.546 0.454
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.547 0.453
I21.9 Acute myocardial infarction, unspecified
0.000 0.560 0.440
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.560 0.439
I45.4 Nonspecific intraventricular block
0.000 0.562 0.438
I47.2 Ventricular tachycardia
0.000 0.563 0.437
I31.9 Disease of pericardium, unspecified
0.000 0.567 0.432
I72.9 Aneurysm of unspecified site
0.000 0.569 0.430
I72.6 Aneurysm and dissection of vertebral artery
0.000 0.569 0.430
I72.5 Aneurysm and dissection of other precerebral arteries
0.000 0.569 0.430
I72.2 Aneurysm of renal artery
0.000 0.569 0.430
I72.1 Aneurysm of artery of upper extremity
0.000 0.569 0.430
I78.0 Hereditary haemorrhagic telangiectasia
0.000 0.571 0.428
I45.2 Bifascicular block
0.000 0.574 0.426
I51.9 Heart disease, unspecified
0.000 0.577 0.423
I72.3 Aneurysm of iliac artery
0.000 0.580 0.420
I72.4 Aneurysm of artery of lower extremity
0.000 0.582 0.418
I06.9 Rheumatic aortic valve disease, unspecified
0.000 0.583 0.417
I06.8 Other rheumatic aortic valve diseases
0.000 0.583 0.417
I06.2 Rheumatic aortic stenosis with insufficiency
0.000 0.583 0.417
I06.1 Rheumatic aortic insufficiency
0.000 0.583 0.417
I06.0 Rheumatic aortic stenosis
0.000 0.583 0.417
I09.9 Rheumatic heart disease, unspecified
0.000 0.583 0.417
I09.8 Other specified rheumatic heart diseases
0.000 0.583 0.417
I09.2 Chronic rheumatic pericarditis
0.000 0.583 0.417
I09.1 Rheumatic diseases of endocardium, valve unspecified
0.000 0.583 0.417
I09.0 Rheumatic myocarditis
0.000 0.583 0.417
I78.9 Disease of capillaries, unspecified
0.000 0.594 0.406
I78.8 Other diseases of capillaries
0.000 0.594 0.406
I28 Other diseases of pulmonary vessels
0.000 0.595 0.405
I05.0 Mitral stenosis
0.000 0.596 0.404
I22.8 Subsequent myocardial infarction of other sites
0.000 0.597 0.403
I27 Other pulmonary heart diseases
0.000 0.599 0.401
I72.0 Aneurysm of carotid artery
0.000 0.600 0.400
I49.4 Other and unspecified premature depolarisation
0.000 0.602 0.398
I34 Nonrheumatic mitral valve disorders
0.000 0.602 0.398
I51.4 Myocarditis, unspecified
0.000 0.609 0.390
I72.8 Aneurysm of other specified arteries
0.000 0.613 0.387
I08.2 Disorders of both aortic and tricuspid valves
0.000 0.622 0.378
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.627 0.373
I01.9 Acute rheumatic heart disease, unspecified
0.000 0.631 0.369
I01.8 Other acute rheumatic heart disease
0.000 0.631 0.369
I01.2 Acute rheumatic myocarditis
0.000 0.631 0.369
I01.1 Acute rheumatic endocarditis
0.000 0.631 0.369
I01.0 Acute rheumatic pericarditis
0.000 0.631 0.369
I02.9 Rheumatic chorea without heart involvement
0.000 0.631 0.369
I02.0 Rheumatic chorea with heart involvement
0.000 0.631 0.369
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.638 0.362
I35.2 Aortic (valve) stenosis with insufficiency
0.001 0.641 0.359
I35.1 Aortic (valve) insufficiency
0.000 0.642 0.357
I70.9 Generalised and unspecified atherosclerosis
0.001 0.645 0.354
I70.8 Atherosclerosis of other arteries
0.001 0.645 0.354
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.648 0.352
I08.9 Multiple valve disease, unspecified
0.000 0.655 0.345
I27.0 Primary pulmonary hypertension
0.000 0.661 0.339
I70.1 Atherosclerosis of renal artery
0.001 0.662 0.338
I30.8 Other forms of acute pericarditis
0.001 0.662 0.337
I30.0 Acute nonspecific idiopathic pericarditis
0.001 0.662 0.337
I08.8 Other multiple valve diseases
0.000 0.669 0.331
I42.0 Dilated cardiomyopathy
0.000 0.670 0.329
I45.9 Conduction disorder, unspecified
0.000 0.674 0.325
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.000 0.679 0.321
I45.6 Preexcitation syndrome
0.000 0.684 0.316
I30.1 Infective pericarditis
0.001 0.685 0.314
I95-I99 Other and unspecified disorders of the circulatory system
0.000 0.690 0.310
I70.0 Atherosclerosis of aorta
0.001 0.693 0.306
I08.0 Disorders of both mitral and aortic valves
0.000 0.694 0.306
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.701 0.299
I08.1 Disorders of both mitral and tricuspid valves
0.000 0.702 0.298
I34.1 Mitral (valve) prolapse
0.000 0.708 0.292
I27.8 Other specified pulmonary heart diseases
0.000 0.708 0.292
I28.9 Disease of pulmonary vessels, unspecified
0.000 0.710 0.290
I28.8 Other specified diseases of pulmonary vessels
0.000 0.710 0.290
I28.1 Aneurysm of pulmonary artery
0.000 0.710 0.290
I28.0 Arteriovenous fistula of pulmonary vessels
0.000 0.710 0.290
I27.1 Kyphoscoliotic heart disease
0.000 0.712 0.288
I44 Atrioventricular and left bundle-branch block
0.000 0.714 0.286
I27.2 Other secondary pulmonary hypertension
0.000 0.721 0.279
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.721 0.279
I49.9 Cardiac arrhythmia, unspecified
0.000 0.723 0.277
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.000 0.726 0.274
I34.9 Nonrheumatic mitral valve disorder, unspecified
0.000 0.729 0.270
I26 Pulmonary embolism
0.000 0.742 0.258
I70.2 Atherosclerosis of arteries of the extremities
0.001 0.745 0.254
I86 Varicose veins of other sites
0.000 0.745 0.255
I70.81 Atherosclerosis of other arteries (with gangrene)
0.001 0.745 0.254
I70.80 Atherosclerosis of other arteries (without gangrene)
0.001 0.745 0.254
I70.91 Generalized and unspecified atherosclerosis (with gangrene)
0.001 0.745 0.254
I70.90 Generalized and unspecified atherosclerosis (without gangrene)
0.001 0.745 0.254
I70.11 Atherosclerosis of renal artery (with gangrene)
0.001 0.757 0.242
I99 Other and unspecified disorders of circulatory system
0.000 0.758 0.242
I34.2 Nonrheumatic mitral (valve) stenosis
0.000 0.759 0.241
I86.1 Scrotal varices
0.000 0.764 0.236
I34.8 Other nonrheumatic mitral valve disorders
0.000 0.772 0.228
I70.10 Atherosclerosis of renal artery (without gangrene)
0.001 0.774 0.225
I44.6 Other and unspecified fascicular block
0.000 0.774 0.226
I70.01 Atherosclerosis of aorta (with gangrene)
0.001 0.780 0.220
I44.7 Left bundle-branch block, unspecified
0.000 0.783 0.217
I78.1 Naevus, nonneoplastic
0.000 0.794 0.206
I44.5 Left posterior fascicular block
0.000 0.795 0.205
I44.4 Left anterior fascicular block
0.000 0.795 0.205
I34.0 Mitral (valve) insufficiency
0.000 0.795 0.205
I86.4 Gastric varices
0.000 0.799 0.201
I88 Nonspecific lymphadenitis
0.000 0.800 0.200
I80 Phlebitis and thrombophlebitis
0.000 0.802 0.198
I27.9 Pulmonary heart disease, unspecified
0.000 0.804 0.196
I44.1 Atrioventricular block, second degree
0.000 0.804 0.196
I89 Other non-infective disorders of lymphatic vessels and lymph nodes
0.000 0.809 0.191
I86.8 Varicose veins of other specified sites
0.000 0.814 0.186
I26.0 Pulmonary embolism with mention of acute cor pulmonale
0.000 0.815 0.185
I83 Varicose veins of lower extremities
0.000 0.817 0.183
I70.21 Atherosclerosis of arteries of extremities (with gangrene)
0.001 0.817 0.182
I86.3 Vulval varices
0.000 0.817 0.183
I86.2 Pelvic varices
0.000 0.817 0.183
I86.0 Sublingual varices
0.000 0.817 0.183
I98 Other disorders of circulatory system in diseases classified elsewhere
0.000 0.821 0.179
I70.00 Atherosclerosis of aorta (without gangrene)
0.001 0.828 0.171
I82 Other venous embolism and thrombosis
0.000 0.828 0.172
I80.0 Phlebitis and thrombophlebitis of superficial vessels of lower extremities
0.000 0.837 0.163
I80.1 Phlebitis and thrombophlebitis of femoral vein
0.000 0.844 0.156
I81 Portal vein thrombosis
0.000 0.845 0.154
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.001 0.847 0.152
I85 Oesophageal varices
0.000 0.848 0.152
I83.0 Varicose veins of lower extremities with ulcer
0.000 0.848 0.152
I89.0 Lymphoedema, not elsewhere classified
0.000 0.850 0.150
I83.1 Varicose veins of lower extremities with inflammation
0.000 0.850 0.149
I80.8 Phlebitis and thrombophlebitis of other sites
0.000 0.851 0.149
I30.9 Acute pericarditis, unspecified
0.003 0.852 0.145
I88.9 Nonspecific lymphadenitis, unspecified
0.000 0.853 0.147
I88.8 Other nonspecific lymphadenitis
0.000 0.856 0.143
I88.1 Chronic lymphadenitis, except mesenteric
0.000 0.856 0.143
I88.0 Nonspecific mesenteric lymphadenitis
0.000 0.856 0.143
I44.3 Other and unspecified atrioventricular block
0.000 0.857 0.143
I73.0 Raynaud's syndrome
0.001 0.860 0.139
I80.3 Phlebitis and thrombophlebitis of lower extremities, unspecified
0.000 0.861 0.138
I89.9 Non-infective disorder of lymphatic vessels and lymph nodes, unspecified
0.000 0.862 0.138
I83.2 Varicose veins of lower extremities with both ulcer and inflammation
0.000 0.866 0.134
I98.8 Other specified disorders of circulatory system in diseases classified elsewhere
0.001 0.871 0.128
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere
0.001 0.871 0.128
I98.1 Cardiovascular disorders in other infectious and parasitic diseases classified elsewhere
0.001 0.871 0.128
I98.0 Cardiovascular syphilis
0.001 0.871 0.128
I82.2 Embolism and thrombosis of vena cava
0.000 0.873 0.127
I89.1 Lymphangitis
0.000 0.874 0.126
I80.9 Phlebitis and thrombophlebitis of unspecified site
0.000 0.874 0.126
I89.8 Other specified non-infective disorders of lymphatic vessels and lymph nodes
0.000 0.876 0.124
I82.3 Embolism and thrombosis of renal vein
0.000 0.876 0.123
I82.1 Thrombophlebitis migrans
0.000 0.876 0.123
I82.0 Budd-Chiari syndrome
0.000 0.876 0.123
I82.9 Embolism and thrombosis of unspecified vein
0.000 0.882 0.118
J90-J94 Other diseases of pleura
0.000 0.882 0.118
I87 Other disorders of veins
0.001 0.882 0.117
I97.2 Postmastectomy lymphoedema syndrome
0.001 0.883 0.116
J90 Pleural effusion, not elsewhere classified
0.000 0.883 0.117
J93 Pneumothorax
0.000 0.885 0.115
J92 Pleural plaque
0.000 0.888 0.112
I97.9 Postprocedural disorder of circulatory system, unspecified
0.001 0.890 0.109
I97.0 Postcardiotomy syndrome
0.001 0.890 0.109
J92.9 Pleural plaque without asbestos
0.000 0.893 0.107
J93.1 Other spontaneous pneumothorax
0.000 0.894 0.106
J94 Other pleural conditions
0.000 0.894 0.106
I44.0 Atrioventricular block, first degree
0.000 0.894 0.106
I44.2 Atrioventricular block, complete
0.000 0.898 0.101
I82.8 Embolism and thrombosis of other specified veins
0.000 0.899 0.100
I80.2 Phlebitis and thrombophlebitis of other deep vessels of lower extremities
0.000 0.901 0.099
J94.8 Other specified pleural conditions
0.000 0.902 0.098
J93.9 Pneumothorax, unspecified
0.000 0.903 0.097
I85.0 Oesophageal varices with bleeding
0.000 0.904 0.096
J93.8 Other pneumothorax
0.000 0.904 0.096
I87.1 Compression of vein
0.000 0.912 0.088
I98.2 Oesophageal varices in diseases classified elsewhere
0.001 0.914 0.085
I85.9 Oesophageal varices without bleeding
0.000 0.915 0.085
I87.9 Disorder of vein, unspecified
0.001 0.915 0.084
I87.0 Postphlebitic syndrome
0.001 0.915 0.084
I97.1 Other functional disturbances following cardiac surgery
0.001 0.915 0.084
J91 Pleural effusion in conditions classified elsewhere
0.000 0.916 0.084
I70.20 Atherosclerosis of arteries of extremities (without gangrene)
0.002 0.916 0.082
J93.0 Spontaneous tension pneumothorax
0.000 0.917 0.083
J92.0 Pleural plaque with presence of asbestos
0.000 0.920 0.080
J94.9 Pleural condition, unspecified
0.000 0.924 0.076
J94.1 Fibrothorax
0.000 0.924 0.076
J94.0 Chylous effusion
0.000 0.924 0.076
J94.2 Haemothorax
0.000 0.927 0.073
I95 Hypotension
0.000 0.927 0.073
E70-E90 Metabolic disorders
0.000 0.929 0.071
Z95.1 Presence of aortocoronary bypass graft
0.000 0.930 0.070
I97.8 Other postprocedural disorders of circulatory system, not elsewhere classified
0.001 0.932 0.067
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.938 0.062
Z95 Presence of cardiac and vascular implants and grafts
0.000 0.939 0.061
E88 Other metabolic disorders
0.000 0.941 0.059
Z95.8 Presence of other cardiac and vascular implants and grafts
0.000 0.942 0.058
Z95.5 Presence of coronary angioplasty implant and graft
0.000 0.942 0.058
E89.0 Postprocedural hypothyroidism
0.000 0.945 0.055
Z95.3 Presence of xenogenic heart valve
0.000 0.945 0.055
I87.2 Venous insufficiency (chronic) (peripheral)
0.001 0.946 0.053
I95.0 Idiopathic hypotension
0.000 0.948 0.052
I87.8 Other specified disorders of veins
0.001 0.948 0.051
E84 Cystic fibrosis
0.000 0.949 0.051
E79 Disorders of purine and pyrimidine metabolism
0.000 0.949 0.051
E77 Disorders of glycoprotein metabolism
0.000 0.949 0.051
E76 Disorders of glycosaminoglycan metabolism
0.000 0.949 0.051
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.949 0.051
E72 Other disorders of amino-acid metabolism
0.000 0.949 0.051
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.949 0.051
E70 Disorders of aromatic amino-acid metabolism
0.000 0.949 0.051
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.949 0.051
E74 Other disorders of carbohydrate metabolism
0.000 0.949 0.051
E73 Lactose intolerance
0.000 0.951 0.049
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.951 0.049
I95.2 Hypotension due to drugs
0.000 0.952 0.048
E89.3 Postprocedural hypopituitarism
0.000 0.955 0.045
E85 Amyloidosis
0.000 0.955 0.045
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.955 0.044
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.955 0.044
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.955 0.044
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.955 0.044
E89.5 Postprocedural testicular hypofunction
0.000 0.955 0.044
E89.4 Postprocedural ovarian failure
0.000 0.955 0.044
E89.1 Postprocedural hypoinsulinaemia
0.000 0.955 0.044
I95.8 Other hypotension
0.000 0.956 0.044
E89.2 Postprocedural hypoparathyroidism
0.000 0.957 0.043
E66.9 Obesity, unspecified
0.000 0.957 0.043
E66 Obesity
0.000 0.957 0.043
E66.8 Other obesity
0.000 0.957 0.043
E88.9 Metabolic disorder, unspecified
0.000 0.958 0.042
E88.8 Other specified metabolic disorders
0.000 0.958 0.042
E88.3 Tumour lysis syndrome
0.000 0.958 0.042
E88.2 Lipomatosis, not elsewhere classified
0.000 0.958 0.042
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.958 0.042
I95.1 Orthostatic hypotension
0.000 0.958 0.042
Z95.4 Presence of other heart-valve replacement
0.000 0.959 0.041
I26.9 Pulmonary embolism without mention of acute cor pulmonale
0.000 0.961 0.039
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.963 0.037
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.963 0.037
E70.3 Albinism
0.000 0.963 0.037
E70.2 Disorders of tyrosine metabolism
0.000 0.963 0.037
E70.1 Other hyperphenylalaninaemias
0.000 0.963 0.037
E70.0 Classical phenylketonuria
0.000 0.963 0.037
E71.3 Disorders of fatty-acid metabolism
0.000 0.963 0.037
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.963 0.037
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.963 0.037
E71.0 Maple-syrup-urine disease
0.000 0.963 0.037
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.963 0.037
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.963 0.037
E72.5 Disorders of glycine metabolism
0.000 0.963 0.037
E72.4 Disorders of ornithine metabolism
0.000 0.963 0.037
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.963 0.037
E72.2 Disorders of urea cycle metabolism
0.000 0.963 0.037
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.963 0.037
E72.0 Disorders of amino-acid transport
0.000 0.963 0.037
E75.6 Lipid storage disorder, unspecified
0.000 0.963 0.037
E75.5 Other lipid storage disorders
0.000 0.963 0.037
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.963 0.037
E75.3 Sphingolipidosis, unspecified
0.000 0.963 0.037
E75.2 Other sphingolipidosis
0.000 0.963 0.037
E75.1 Other gangliosidosis
0.000 0.963 0.037
E75.0 GM2 gangliosidosis
0.000 0.963 0.037
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.963 0.037
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.963 0.037
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.963 0.037
E76.2 Other mucopolysaccharidoses
0.000 0.963 0.037
E76.1 Mucopolysaccharidosis, type II
0.000 0.963 0.037
E76.0 Mucopolysaccharidosis, type I
0.000 0.963 0.037
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.963 0.037
E77.8 Other disorders of glycoprotein metabolism
0.000 0.963 0.037
E77.1 Defects in glycoprotein degradation
0.000 0.963 0.037
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.963 0.037

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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