TreeWAS – Variant ID: rs1265564

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E03.9 Hypothyroidism, unspecified	1.000	0.000	0.000
I21.1 Acute transmural myocardial infarction of inferior wall	1.000	0.000	0.000
I25.1 Atherosclerotic heart disease	1.000	0.000	0.000
I10 Essential (primary) hypertension	1.000	0.000	0.000
I25 Chronic ischaemic heart disease	1.000	0.000	0.000
I21 Acute myocardial infarction	1.000	0.000	0.000
I20-I25 Ischaemic heart diseases	1.000	0.000	0.000
Z95 Presence of cardiac and vascular implants and grafts	1.000	0.000	0.000
E03 Other hypothyroidism	1.000	0.000	0.000
Z95.5 Presence of coronary angioplasty implant and graft	1.000	0.000	0.000
Z95.2 Presence of prosthetic heart valve	0.999	0.001	0.000
I25.9 Chronic ischaemic heart disease, unspecified	0.999	0.001	0.000
E00-E07 Disorders of thyroid gland	0.999	0.001	0.000
I21.0 Acute transmural myocardial infarction of anterior wall	0.998	0.002	0.000
Z95.1 Presence of aortocoronary bypass graft	0.996	0.004	0.000
I25.8 Other forms of chronic ischaemic heart disease	0.996	0.004	0.000
Z95.4 Presence of other heart-valve replacement	0.992	0.008	0.000
I22 Subsequent myocardial infarction	0.991	0.009	0.000
E06 Thyroiditis	0.986	0.014	0.000
I10-I15 Hypertensive diseases	0.981	0.019	0.000
I25.2 Old myocardial infarction	0.976	0.024	0.000
I25.5 Ischaemic cardiomyopathy	0.976	0.024	0.000
C50 Malignant neoplasm of breast	0.000	0.025	0.975
C50.4 Upper-outer quadrant of breast	0.000	0.025	0.975
I22.1 Subsequent myocardial infarction of inferior wall	0.972	0.028	0.000
E06.3 Autoimmune thyroiditis	0.971	0.029	0.000
C50.2 Upper-inner quadrant of breast	0.000	0.029	0.971
Chapter IV Endocrine, nutritional and metabolic diseases	0.949	0.051	0.000
E20-E35 Disorders of other endocrine glands	0.948	0.052	0.000
E27 Other disorders of adrenal gland	0.947	0.053	0.000
C50.8 Overlapping lesion of breast	0.000	0.056	0.944
E27.1 Primary adrenocortical insufficiency	0.944	0.056	0.000
E05 Thyrotoxicosis [hyperthyroidism]	0.944	0.056	0.000
E05.9 Thyrotoxicosis, unspecified	0.935	0.065	0.000
Chapter IX Diseases of the circulatory system	0.916	0.084	0.000
E03.8 Other specified hypothyroidism	0.906	0.094	0.000
I21.9 Acute myocardial infarction, unspecified	0.906	0.094	0.000
I15 Secondary hypertension	0.906	0.094	0.000
I22.0 Subsequent myocardial infarction of anterior wall	0.896	0.104	0.000
C50.0 Nipple and areola	0.000	0.124	0.876
I21.4 Acute subendocardial myocardial infarction	0.862	0.138	0.000
I23 Certain current complications following acute myocardial infarction	0.860	0.140	0.000
E28 Ovarian dysfunction	0.852	0.148	0.000
C50.1 Central portion of breast	0.000	0.153	0.847
E27.2 Addisonian crisis	0.847	0.153	0.000
D63.8 Anaemia in other chronic diseases classified elsewhere	0.838	0.162	0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.836	0.164	0.000
D55-D59 Haemolytic anaemias	0.833	0.167	0.000
D63 Anaemia in chronic diseases classified elsewhere	0.829	0.171	0.000
E02 Subclinical iodine-deficiency hypothyroidism	0.828	0.172	0.000
I22.9 Subsequent myocardial infarction of unspecified site	0.827	0.173	0.000
I15.1 Hypertension secondary to other renal disorders	0.826	0.174	0.000
D60-D64 Aplastic and other anaemias	0.825	0.175	0.000
D59 Acquired haemolytic anaemia	0.823	0.177	0.000
I13 Hypertensive heart and renal disease	0.815	0.185	0.000
Z95.8 Presence of other cardiac and vascular implants and grafts	0.815	0.185	0.000
D59.1 Other autoimmune haemolytic anaemias	0.813	0.187	0.000
D80-D89 Certain disorders involving the immune mechanism	0.812	0.188	0.000
I21.2 Acute transmural myocardial infarction of other sites	0.812	0.188	0.000
D86 Sarcoidosis	0.807	0.193	0.000
E50-E64 Other nutritional deficiencies	0.805	0.195	0.000
E06.9 Thyroiditis, unspecified	0.805	0.195	0.000
D86.0 Sarcoidosis of lung	0.787	0.213	0.000
E10-E14 Diabetes mellitus	0.787	0.213	0.000
E10 Insulin-dependent diabetes mellitus	0.777	0.223	0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.772	0.228	0.000
E03.1 Congenital hypothyroidism without goitre	0.770	0.230	0.000
E22 Hyperfunction of pituitary gland	0.766	0.234	0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.765	0.235	0.000
I25.6 Silent myocardial ischaemia	0.763	0.236	0.000
E20 Hypoparathyroidism	0.762	0.238	0.000
D86.9 Sarcoidosis, unspecified	0.761	0.239	0.000
E23 Hypofunction and other disorders of pituitary gland	0.756	0.244	0.000
E27.8 Other specified disorders of adrenal gland	0.755	0.245	0.000
E27.4 Other and unspecified adrenocortical insufficiency	0.742	0.258	0.000
I15.0 Renovascular hypertension	0.741	0.259	0.000
E31 Polyglandular dysfunction	0.732	0.267	0.000
E28.3 Primary ovarian failure	0.732	0.268	0.000
E06.5 Other chronic thyroiditis	0.730	0.270	0.000
C50.9 Breast, unspecified	0.000	0.274	0.726
I25.4 Coronary artery aneurysm	0.725	0.275	0.000
D58 Other hereditary haemolytic anaemias	0.723	0.277	0.000
I21.X Presumed acute myicardial infaction (unconfirmed)	0.717	0.283	0.000
E10.5 With peripheral circulatory complications	0.717	0.283	0.000
E03.5 Myxoedema coma	0.717	0.283	0.000
E03.4 Atrophy of thyroid (acquired)	0.717	0.283	0.000
E03.3 Postinfectious hypothyroidism	0.717	0.283	0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.716	0.284	0.000
E00 Congenital iodine-deficiency syndrome	0.716	0.284	0.000
E10.1 With ketoacidosis	0.716	0.284	0.000
D69 Purpura and other haemorrhagic conditions	0.715	0.285	0.000
C50.5 Lower-outer quadrant of breast	0.000	0.286	0.714
E28.2 Polycystic ovarian syndrome	0.712	0.288	0.000
I23.8 Other current complications following acute myocardial infarction	0.712	0.288	0.000
E58 Dietary calcium deficiency	0.710	0.290	0.000
E03.0 Congenital hypothyroidism with diffuse goitre	0.709	0.291	0.000
E06.4 Drug-induced thyroiditis	0.707	0.293	0.000
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.707	0.293	0.000
E06.0 Acute thyroiditis	0.707	0.293	0.000
D69.3 Idiopathic thrombocytopenic purpura	0.703	0.297	0.000
E07 Other disorders of thyroid	0.703	0.297	0.000
D70-D77 Other diseases of blood and blood-forming organs	0.699	0.301	0.000
E06.1 Subacute thyroiditis	0.696	0.304	0.000
I23.2 Ventricular septal defect as current complication following acute myocardial infarction	0.696	0.304	0.000
E10.3 With ophthalmic complications	0.693	0.307	0.000
I12 Hypertensive renal disease	0.687	0.313	0.000
E32 Diseases of thymus	0.687	0.313	0.000
D75 Other diseases of blood and blood-forming organs	0.683	0.317	0.000
E25 Adrenogenital disorders	0.681	0.319	0.000
E35 Disorders of endocrine glands in diseases classified elsewhere	0.680	0.320	0.000
E30 Disorders of puberty, not elsewhere classified	0.680	0.320	0.000
E27.5 Adrenomedullary hyperfunction	0.679	0.321	0.000
E27.0 Other adrenocortical overactivity	0.679	0.321	0.000
E26 Hyperaldosteronism	0.679	0.321	0.000
E05.5 Thyroid crisis or storm	0.676	0.323	0.000
E05.4 Thyrotoxicosis factitia	0.676	0.323	0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.676	0.323	0.000
D56 Thalassaemia	0.676	0.324	0.000
I25.3 Aneurysm of heart	0.663	0.337	0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.663	0.337	0.000
I15.2 Hypertension secondary to endocrine disorders	0.662	0.338	0.000
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure	0.660	0.340	0.000
E22.1 Hyperprolactinaemia	0.657	0.343	0.000
D75.1 Secondary polycythaemia	0.654	0.346	0.000
D86.1 Sarcoidosis of lymph nodes	0.650	0.350	0.000
E23.2 Diabetes insipidus	0.650	0.350	0.000
I15.8 Other secondary hypertension	0.649	0.351	0.000
I21.3 Acute transmural myocardial infarction of unspecified site	0.648	0.352	0.000
D59.0 Drug-induced autoimmune haemolytic anaemia	0.647	0.353	0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone	0.645	0.355	0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.644	0.356	0.000
D58.9 Hereditary haemolytic anaemia, unspecified	0.640	0.360	0.000
I13.1 Hypertensive heart and renal disease with renal failure	0.640	0.360	0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]	0.638	0.361	0.000
E53 Deficiency of other B group vitamins	0.637	0.363	0.000
E23.6 Other disorders of pituitary gland	0.634	0.366	0.000
D69.4 Other primary thrombocytopenia	0.632	0.368	0.000
I11 Hypertensive heart disease	0.631	0.369	0.000
D66 Hereditary factor VIII deficiency	0.630	0.370	0.000
E40-E46 Malnutrition	0.629	0.371	0.000
D75.2 Essential thrombocytosis	0.629	0.371	0.000
E20.9 Hypoparathyroidism, unspecified	0.628	0.372	0.000
I25.0 Atherosclerotic cardiovascular disease, so described	0.625	0.374	0.000
E10.0 With coma	0.625	0.375	0.000
I00-I02 Acute rheumatic fever	0.622	0.378	0.000
I15.9 Seconday hypertension, unspecified	0.622	0.378	0.000
Z95.3 Presence of xenogenic heart valve	0.621	0.379	0.000
E05.8 Other thyrotoxicosis	0.618	0.381	0.000
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction	0.617	0.383	0.000
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction	0.617	0.383	0.000
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction	0.617	0.383	0.000
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction	0.617	0.383	0.000
I23.1 Atrial septal defect as current complication following acute myocardial infarction	0.617	0.383	0.000
I23.0 Haemopericardium as current complication following acute myocardial infarction	0.617	0.383	0.000
E28.9 Ovarian dysfunction, unspecified	0.611	0.389	0.000
E28.8 Other ovarian dysfunction	0.611	0.389	0.000
E28.1 Androgen excess	0.611	0.389	0.000
E28.0 Oestrogen excess	0.611	0.389	0.000
D57 Sickle-cell disorders	0.610	0.390	0.000
D83 Common variable immunodeficiency	0.609	0.391	0.000
E27.3 Drug-induced adrenocortical insufficiency	0.608	0.391	0.000
E34 Other endocrine disorders	0.607	0.393	0.000
D68 Other coagulation defects	0.603	0.397	0.000
E63 Other nutritional deficiencies	0.602	0.398	0.000
D82 Immunodeficiency associated with other major defects	0.598	0.402	0.000
D55 Anaemia due to enzyme disorders	0.597	0.402	0.000
D63.1 Anaemia in other chronic diseases classified elsewhere	0.594	0.406	0.000
D86.3 Sarcoidosis of skin	0.592	0.408	0.000
D59.9 Acquired haemolytic anaemia, unspecified	0.592	0.408	0.000
E10.4 With neurological complications	0.591	0.409	0.000
D59.8 Other acquired haemolytic anaemias	0.590	0.410	0.000
D59.6 Haemoglobinuria due to haemolysis from other external causes	0.590	0.410	0.000
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]	0.590	0.410	0.000
D59.4 Other nonautoimmune haemolytic anaemias	0.590	0.410	0.000
D59.3 Haemolytic-uraemic syndrome	0.590	0.410	0.000
D59.2 Drug-induced nonautoimmune haemolytic anaemia	0.590	0.410	0.000
I13.9 Hypertensive heart and renal disease, unspecified	0.585	0.415	0.000
I13.0 Hypertensive heart and renal disease with (congestive) heart failure	0.585	0.415	0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.583	0.416	0.000
D81 Combined immunodeficiencies	0.582	0.417	0.000
E31.0 Autoimmune polyglandular failure	0.578	0.422	0.000
E64 Sequelae of malnutrition and other nutritional deficiencies	0.577	0.423	0.000
E50 Vitamin A deficiency	0.577	0.423	0.000
E60 Dietary zinc deficiency	0.577	0.423	0.000
E59 Dietary selenium deficiency	0.577	0.423	0.000
E54 Ascorbic acid deficiency	0.577	0.423	0.000
E52 Niacin deficiency [pellagra]	0.577	0.423	0.000
E10.2 With renal complications	0.577	0.423	0.000
C77.3 Axillary and upper limb lymph nodes	0.000	0.429	0.571
E61 Deficiency of other nutrient elements	0.569	0.431	0.000
E12 Malnutrition-related diabetes mellitus	0.564	0.436	0.000
D68.5 Primary Thrombophilia	0.563	0.437	0.000
E51 Thiamine deficiency	0.559	0.441	0.000
Z95.9 Presence of cardiac and vascular implant and graft, unspecified	0.553	0.447	0.000
E53.9 Vitamin B deficiency, unspecified	0.550	0.450	0.000
E22.9 Hyperfunction of pituitary gland, unspecified	0.549	0.451	0.000
E22.8 Other hyperfunction of pituitary gland	0.549	0.451	0.000
E20.8 Other hypoparathyroidism	0.546	0.454	0.000
E20.1 Pseudohypoparathyroidism	0.546	0.454	0.000
E20.0 Idiopathic hypoparathyroidism	0.546	0.454	0.000
E07.9 Disorder of thyroid, unspecified	0.546	0.454	0.000
E56 Other vitamin deficiencies	0.543	0.456	0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified	0.542	0.458	0.000
E23.1 Drug-induced hypopituitarism	0.542	0.458	0.000
D58.2 Other haemoglobinopathies	0.536	0.464	0.000
D84 Other immunodeficiencies	0.535	0.465	0.000
I22.8 Subsequent myocardial infarction of other sites	0.535	0.465	0.000
C50.6 Axillary tail of breast	0.000	0.467	0.532
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes	0.532	0.468	0.000
D56.3 Thalassaemia trait	0.531	0.469	0.000
D69.9 Haemorrhagic condition, unspecified	0.530	0.469	0.000
I28 Other diseases of pulmonary vessels	0.527	0.473	0.000
D56.1 Beta thalassaemia	0.526	0.474	0.000
D67 Hereditary factor IX deficiency	0.526	0.474	0.000
D69.1 Qualitative platelet defects	0.526	0.474	0.000
E31.9 Polyglandular dysfunction, unspecified	0.525	0.475	0.000
E31.8 Other polyglandular dysfunction	0.525	0.475	0.000
E31.1 Polyglandular hyperfunction	0.525	0.475	0.000
E10.8 With unspecified complications	0.525	0.475	0.000
D58.8 Other specified hereditary haemolytic anaemias	0.518	0.481	0.000
D58.1 Hereditary elliptocytosis	0.518	0.481	0.000
E10.6 With other specified complications	0.517	0.483	0.000
E00.9 Congenital iodine-deficiency syndrome, unspecified	0.513	0.487	0.000
E00.2 Congenital iodine-deficiency syndrome, mixed type	0.513	0.487	0.000
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type	0.513	0.487	0.000
E00.0 Congenital iodine-deficiency syndrome, neurological type	0.513	0.487	0.000
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions	0.513	0.487	0.000
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified	0.513	0.487	0.000
E01.1 Iodine-deficiency-related multinodular (endemic) goitre	0.513	0.487	0.000
E01.0 Iodine-deficiency-related diffuse (endemic) goitre	0.513	0.487	0.000
D69.8 Other specified haemorrhagic conditions	0.512	0.488	0.000
E55 Vitamin D deficiency	0.510	0.490	0.000
E26.0 Primary hyperaldosteronism	0.510	0.490	0.000
D58.0 Hereditary spherocytosis	0.509	0.490	0.000
D60.9 Acquired pure red cell aplasia, unspecified	0.505	0.495	0.000
E07.1 Dyshormogenetic goitre	0.504	0.496	0.000
E07.0 Hypersecretion of calcitonin	0.504	0.496	0.000
E10.7 With multiple complications	0.504	0.496	0.000
D73 Diseases of spleen	0.502	0.498	0.000
D63.0 Anaemia in neoplastic disease	0.501	0.499	0.000
D74 Methaemoglobinaemia	0.501	0.499	0.000
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere	0.501	0.499	0.000
D71 Functional disorders of polymorphonuclear neutrophils	0.501	0.499	0.000
E32.8 Other diseases of thymus	0.500	0.500	0.000
D75.9 Disease of blood and blood-forming organs, unspecified	0.499	0.501	0.000
I70-I79 Diseases of arteries, arterioles and capillaries	0.494	0.506	0.000
E32.9 Disease of thymus, unspecified	0.493	0.507	0.000
E32.1 Abscess of thymus	0.493	0.507	0.000
E32.0 Persistent hyperplasia of thymus	0.493	0.507	0.000
I12.9 Hypertensive renal disease without renal failure	0.493	0.507	0.000
E27.9 Disorder of adrenal gland, unspecified	0.492	0.507	0.000
D61 Other aplastic anaemias	0.491	0.509	0.000
D68.2 Hereditary deficiency of other clotting factors	0.489	0.511	0.000
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency	0.489	0.511	0.000
E25.9 Adrenogenital disorder, unspecified	0.488	0.512	0.000
E25.8 Other adrenogenital disorders	0.488	0.512	0.000
E30.9 Disorder of puberty, unspecified	0.487	0.512	0.000
E30.8 Other disorders of puberty	0.487	0.512	0.000
E30.1 Precocious puberty	0.487	0.512	0.000
E30.0 Delayed puberty	0.487	0.512	0.000
E35.8 Disorders of other endocrine glands in diseases classified elsewhere	0.487	0.512	0.000
E35.1 Disorders of adrenal glands in diseases classified elsewhere	0.487	0.512	0.000
E35.0 Disorders of thyroid gland in diseases classified elsewhere	0.487	0.512	0.000
E24 Cushing's syndrome	0.487	0.513	0.000
E26.8 Other hyperaldosteronism	0.487	0.513	0.000
E26.1 Secondary hyperaldosteronism	0.487	0.513	0.000
D56.9 Thalassaemia, unspecified	0.484	0.515	0.000
D56.8 Other thalassaemias	0.484	0.515	0.000
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]	0.484	0.515	0.000
D56.2 Delta-beta thalassaemia	0.484	0.515	0.000
D56.0 Alpha thalassaemia	0.484	0.515	0.000
D86.8 Sarcoidosis of other and combined sites	0.481	0.518	0.000
E34.0 Carcinoid syndrome	0.478	0.521	0.000
I12.0 Hypertensive renal disease with renal failure	0.477	0.523	0.000
E10.9 Without complications	0.476	0.524	0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified	0.475	0.525	0.000
I74 Arterial embolism and thrombosis	0.474	0.526	0.000
D68.1 Hereditary factor XI deficiency	0.472	0.527	0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.470	0.530	0.000
D83.9 Common variable immunodeficiency, unspecified	0.463	0.537	0.000
E05.0 Thyrotoxicosis with diffuse goitre	0.461	0.539	0.000
E26.9 Hyperaldosteronism, unspecified	0.460	0.540	0.000
D60.8 Other acquired pure red cell aplasias	0.458	0.542	0.000
D60.1 Transient acquired pure red cell aplasia	0.458	0.542	0.000
D60.0 Chronic acquired pure red cell aplasia	0.458	0.542	0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.458	0.542	0.000
D75.8 Other specified diseases of blood and blood-forming organs	0.458	0.542	0.000
E63.9 Nutritional deficiency, unspecified	0.457	0.543	0.000
E53.1 Pyridoxine deficiency	0.457	0.543	0.000
E53.0 Riboflavin deficiency	0.457	0.543	0.000
E44 Protein-energy malnutrition of moderate and mild degree	0.451	0.549	0.000
E45 Retarded development following protein-energy malnutrition	0.451	0.549	0.000
E43 Unspecified severe protein-energy malnutrition	0.451	0.549	0.000
E42 Marasmic kwashiorkor	0.451	0.549	0.000
E41 Nutritional marasmus	0.451	0.549	0.000
E40 Kwashiorkor	0.451	0.549	0.000
E13 Other specified diabetes mellitus	0.450	0.550	0.000
D57.1 Sickle-cell anaemia without crisis	0.449	0.550	0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system	0.449	0.551	0.000
E23.0 Hypopituitarism	0.449	0.551	0.000
I24 Other acute ischaemic heart diseases	0.449	0.551	0.000
I74.5 Embolism and thrombosis of iliac artery	0.448	0.552	0.000
D69.5 Secondary thrombocytopenia	0.447	0.553	0.000
D68.3 Haemorrhagic disorder due to circulating anticoagulants	0.446	0.554	0.000
I02 Rheumatic chorea	0.446	0.554	0.000
I01 Rheumatic fever with heart involvement	0.446	0.554	0.000
E34.3 Short stature, not elsewhere classified	0.445	0.555	0.000
D82.1 Di George's syndrome	0.444	0.555	0.000
I28.8 Other specified diseases of pulmonary vessels	0.444	0.556	0.000
E29 Testicular dysfunction	0.443	0.556	0.001
D75.0 Familial erythrocytosis	0.441	0.559	0.000
D57.8 Other sickle-cell disorders	0.437	0.563	0.000
D57.3 Sickle-cell trait	0.437	0.563	0.000
D57.2 Double heterozygous sickling disorders	0.437	0.563	0.000
D57.0 Sickle-cell anaemia with crisis	0.437	0.563	0.000
D83.8 Other common variable immunodeficiencies	0.437	0.563	0.000
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells	0.437	0.563	0.000
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders	0.437	0.563	0.000
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function	0.437	0.563	0.000
E34.5 Androgen resistance syndrome	0.435	0.565	0.000
E34.4 Constitutional tall stature	0.435	0.565	0.000
E34.2 Ectopic hormone secretion, not elsewhere classified	0.435	0.565	0.000
E34.1 Other hypersecretion of intestinal hormones	0.435	0.565	0.000
E07.8 Other specified disorders of thyroid	0.434	0.566	0.000
D73.3 Abscess of spleen	0.434	0.566	0.000
E63.8 Other specified nutritional deficiencies	0.432	0.568	0.000
E63.1 Imbalance of constituents of food intake	0.432	0.568	0.000
E63.0 Essential fatty acid [EFA] deficiency	0.432	0.568	0.000
D69.2 Other nonthrombocytopenic purpura	0.432	0.568	0.000
D68.4 Acquired coagulation factor deficiency	0.431	0.569	0.000
D68.6 Other Thrombophilia	0.431	0.569	0.000
I11.9 Hypertensive heart disease without (congestive) heart failure	0.431	0.569	0.000
D82.9 Immunodeficiency associated with major defect, unspecified	0.429	0.571	0.000
D82.8 Immunodeficiency associated with other specified major defects	0.429	0.571	0.000
D82.4 Hyperimmunoglobulin E [IgE] syndrome	0.429	0.571	0.000
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus	0.429	0.571	0.000
D82.2 Immunodeficiency with short-limbed stature	0.429	0.571	0.000
D82.0 Wiskott-Aldrich syndrome	0.429	0.571	0.000
D55.9 Anaemia due to enzyme disorder, unspecified	0.428	0.571	0.000
D55.8 Other anaemias due to enzyme disorders	0.428	0.571	0.000
D55.3 Anaemia due to disorders of nucleotide metabolism	0.428	0.571	0.000
D55.2 Anaemia due to disorders of glycolytic enzymes	0.428	0.571	0.000
D55.1 Anaemia due to other disorders of glutathione metabolism	0.428	0.571	0.000
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency	0.428	0.571	0.000
D72 Other disorders of white blood cells	0.428	0.572	0.000
E23.7 Disorder of pituitary gland, unspecified	0.421	0.579	0.000
E15 Nondiabetic hypoglycaemic coma	0.418	0.581	0.000
D81.9 Combined immunodeficiency, unspecified	0.418	0.582	0.000
D81.8 Other combined immunodeficiencies	0.418	0.582	0.000
D81.7 Major histocompatibility complex class II deficiency	0.418	0.582	0.000
D81.6 Major histocompatibility complex class I deficiency	0.418	0.582	0.000
D81.5 Purine nucleoside phosphorylase [PNP] deficiency	0.418	0.582	0.000
D81.4 Nezelof's syndrome	0.418	0.582	0.000
D81.3 Adenosine deaminase [ADA] deficiency	0.418	0.582	0.000
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers	0.418	0.582	0.000
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers	0.418	0.582	0.000
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis	0.418	0.582	0.000
C50-C50 Malignant neoplasm of breast	0.000	0.584	0.416
E50.9 Vitamin A deficiency, unspecified	0.414	0.586	0.000
E50.8 Other manifestations of vitamin A deficiency	0.414	0.586	0.000
E50.7 Other ocular manifestations of vitamin A deficiency	0.414	0.586	0.000
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea	0.414	0.586	0.000
E50.5 Vitamin A deficiency with night blindness	0.414	0.586	0.000
E50.4 Vitamin A deficiency with keratomalacia	0.414	0.586	0.000
E50.3 Vitamin A deficiency with corneal ulceration and xerosis	0.414	0.586	0.000
E50.2 Vitamin A deficiency with corneal xerosis	0.414	0.586	0.000
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis	0.414	0.586	0.000
E50.0 Vitamin A deficiency with conjunctival xerosis	0.414	0.586	0.000
E64.9 Sequelae of unspecified nutritional deficiency	0.414	0.586	0.000
E64.8 Sequelae of other nutritional deficiencies	0.414	0.586	0.000
E64.3 Sequelae of rickets	0.414	0.586	0.000
E64.2 Sequelae of vitamin C deficiency	0.414	0.586	0.000
E64.1 Sequelae of vitamin A deficiency	0.414	0.586	0.000
E64.0 Sequelae of protein-energy malnutrition	0.414	0.586	0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.412	0.588	0.000
I27 Other pulmonary heart diseases	0.412	0.588	0.000
D69.0 Allergic purpura	0.411	0.589	0.000
I00 Rheumatic fever without mention of heart involvement	0.411	0.589	0.000
E61.9 Deficiency of nutrient element, unspecified	0.408	0.592	0.000
E61.8 Deficiency of other specified nutrient elements	0.408	0.592	0.000
E61.7 Deficiency of multiple nutrient elements	0.408	0.592	0.000
E61.6 Vanadium deficiency	0.408	0.592	0.000
E61.5 Molybdenum deficiency	0.408	0.592	0.000
E61.4 Chromium deficiency	0.408	0.592	0.000
E61.3 Manganese deficiency	0.408	0.592	0.000
E61.0 Copper deficiency	0.408	0.592	0.000
I11.0 Hypertensive heart disease with (congestive) heart failure	0.407	0.592	0.000
E61.1 Iron deficiency	0.407	0.593	0.000
D80 Immunodeficiency with predominantly antibody defects	0.406	0.594	0.000
E12.9 Without complications	0.404	0.595	0.000
E12.8 With unspecified complications	0.404	0.595	0.000
E12.7 With multiple complications	0.404	0.595	0.000
E12.6 With other specified complications	0.404	0.595	0.000
E12.5 With peripheral circulatory complications	0.404	0.595	0.000
E12.4 With neurological complications	0.404	0.595	0.000
E12.3 With ophthalmic complications	0.404	0.595	0.000
E12.2 With renal complications	0.404	0.595	0.000
E12.1 With ketoacidosis	0.404	0.595	0.000
E12.0 With coma	0.404	0.595	0.000
I26 Pulmonary embolism	0.404	0.596	0.000
D73.4 Cyst of spleen	0.403	0.597	0.000
E51.9 Thiamine deficiency, unspecified	0.401	0.599	0.000
E51.8 Other manifestations of thiamine deficiency	0.401	0.599	0.000
E51.1 Beriberi	0.401	0.599	0.000
E61.2 Magnesium deficiency	0.401	0.599	0.000
I74.9 Embolism and thrombosis of unspecified artery	0.401	0.599	0.000
E46 Unspecified protein-energy malnutrition	0.400	0.600	0.000
D84.8 Other specified immunodeficiencies	0.395	0.605	0.000
E56.9 Vitamin deficiency, unspecified	0.390	0.610	0.000
E56.8 Deficiency of other vitamins	0.390	0.610	0.000
E56.0 Deficiency of vitamin E	0.390	0.610	0.000
E53.8 Deficiency of other specified B group vitamins	0.387	0.612	0.000
D89.9 Disorder involving the immune mechanism, unspecified	0.386	0.614	0.000
D61.1 Drug-induced aplastic anaemia	0.385	0.615	0.000
E34.8 Other specified endocrine disorders	0.385	0.615	0.000
D84.0 Lymphocyte function antigen-1 [LFA-1] defect	0.384	0.616	0.000
E51.2 Wernicke's encephalopathy	0.383	0.617	0.000
I74.2 Embolism and thrombosis of arteries of the upper extremities	0.381	0.619	0.000
I28.9 Disease of pulmonary vessels, unspecified	0.378	0.622	0.000
I28.1 Aneurysm of pulmonary artery	0.378	0.622	0.000
I28.0 Arteriovenous fistula of pulmonary vessels	0.378	0.622	0.000
D73.1 Hypersplenism	0.376	0.623	0.000
D68.0 Von Willebrand's disease	0.373	0.627	0.000
I27.0 Primary pulmonary hypertension	0.371	0.629	0.000
D50-D53 Nutritional anaemias	0.371	0.629	0.000
I74.1 Embolism and thrombosis of other and unspecified parts of aorta	0.369	0.630	0.000
D61.0 Constitutional aplastic anaemia	0.369	0.631	0.000
I05-I09 Chronic rheumatic heart diseases	0.369	0.631	0.000
E21.3 Hyperparathyroidism, unspecified	0.367	0.633	0.000
I73 Other peripheral vascular diseases	0.367	0.633	0.000
D84.1 Defects in the complement system	0.367	0.633	0.000
E55.0 Rickets, active	0.366	0.634	0.000
I72 Other aneurysm	0.364	0.636	0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities	0.361	0.639	0.000
D73.2 Chronic congestive splenomegaly	0.360	0.640	0.000
D74.9 Methaemoglobinaemia, unspecified	0.359	0.641	0.000
D74.8 Other methaemoglobinaemias	0.359	0.641	0.000
D74.0 Congenital methaemoglobinaemia	0.359	0.641	0.000
D89.0 Polyclonal hypergammaglobulinaemia	0.357	0.642	0.000
D73.9 Disease of spleen, unspecified	0.356	0.644	0.000
E56.1 Deficiency of vitamin K	0.356	0.644	0.000
E24.2 Drug-induced Cushing's syndrome	0.356	0.644	0.000
D61.8 Other specified aplastic anaemias	0.352	0.648	0.000
D61.3 Idiopathic aplastic anaemia	0.352	0.648	0.000
D61.2 Aplastic anaemia due to other external agents	0.352	0.648	0.000
I70 Atherosclerosis	0.352	0.648	0.000
E24.8 Other Cushing's syndrome	0.349	0.651	0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome	0.349	0.651	0.000
E24.3 Ectopic ACTH syndrome	0.349	0.651	0.000
E24.1 Nelson's syndrome	0.349	0.651	0.000
I72.4 Aneurysm of artery of lower extremity	0.348	0.652	0.000
E21.2 Other hyperparathyroidism	0.347	0.653	0.000
D84.9 Immunodeficiency, unspecified	0.343	0.657	0.000
I73.9 Peripheral vascular disease, unspecified	0.343	0.657	0.000
D89.3 Immune reconstitution syndrome	0.340	0.659	0.000
E21.5 Disorder of parathyroid gland, unspecified	0.339	0.661	0.000
E34.9 Endocrine disorder, unspecified	0.339	0.661	0.000
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified	0.336	0.664	0.000
I74.0 Embolism and thrombosis of abdominal aorta	0.336	0.664	0.000
I95-I99 Other and unspecified disorders of the circulatory system	0.334	0.666	0.000
D80.9 Immunodeficiency with predominantly antibody defects, unspecified	0.333	0.666	0.000
D64 Other anaemias	0.327	0.673	0.000
E44.1 Mild protein-energy malnutrition	0.324	0.676	0.000
E44.0 Moderate protein-energy malnutrition	0.324	0.676	0.000
E13.8 With unspecified complications	0.323	0.677	0.000
E13.7 With multiple complications	0.323	0.677	0.000
E13.6 With other specified complications	0.323	0.677	0.000
E13.5 With peripheral circulatory complications	0.323	0.677	0.000
E13.4 With neurological complications	0.323	0.677	0.000
E13.2 With renal complications	0.323	0.677	0.000
E13.1 With ketoacidosis	0.323	0.677	0.000
E13.0 With coma	0.323	0.677	0.000
D76.2 Haemophagocytic syndrome, infection-associated	0.322	0.678	0.000
D76.1 Haemophagocytic lymphohistiocytosis	0.322	0.678	0.000
D76.0 Langerhans' cell histiocytosis, not elsewhere classified	0.322	0.678	0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction	0.322	0.678	0.000
E16 Other disorders of pancreatic internal secretion	0.321	0.679	0.000
E13.3 With ophthalmic complications	0.321	0.679	0.000
I01.9 Acute rheumatic heart disease, unspecified	0.320	0.680	0.000
I01.8 Other acute rheumatic heart disease	0.320	0.680	0.000
I01.2 Acute rheumatic myocarditis	0.320	0.680	0.000
I01.1 Acute rheumatic endocarditis	0.320	0.680	0.000
I01.0 Acute rheumatic pericarditis	0.320	0.680	0.000
I02.9 Rheumatic chorea without heart involvement	0.320	0.680	0.000
I02.0 Rheumatic chorea with heart involvement	0.320	0.680	0.000
D62 Acute posthaemorrhagic anaemia	0.320	0.680	0.000
I74.4 Embolism and thrombosis of arteries of extremities, unspecified	0.320	0.680	0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.318	0.682	0.000
D68.8 Other specified coagulation defects	0.318	0.682	0.000
E29.8 Other testicular dysfunction	0.318	0.682	0.001
E29.0 Testicular hyperfunction	0.318	0.682	0.001
E29.9 Testicular dysfunction, unspecified	0.311	0.688	0.001
E21.1 Secondary hyperparathyroidism, not elsewhere classified	0.310	0.690	0.000
D53 Other nutritional anaemias	0.309	0.691	0.000
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia	0.307	0.692	0.000
I06 Rheumatic aortic valve diseases	0.307	0.693	0.000
D72.9 Disorder of white blood cells, unspecified	0.307	0.693	0.000
D72.0 Genetic anomalies of leukocytes	0.307	0.693	0.000
E21.4 Other specified disorders of parathyroid gland	0.304	0.696	0.000
I24.9 Acute ischaemic heart disease, unspecified	0.304	0.696	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations