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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs12821981
log Bayes Factor = 18.716
Chromosome 12   position 2,741,217  (GRCh37) Explore rs12821981 on Ensembl!
Variant rs12821981 is part of Cluster X0232

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter XI Diseases of the digestive system
1.000 0.000 0.000
Chapter X Diseases of the respiratory system
1.000 0.000 0.000
M20-M25 Other joint disorders
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
Chapter V Mental and behavioural disorders
0.999 0.001 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.998 0.002 0.000
J30-J39 Other diseases of upper respiratory tract
0.998 0.002 0.000
K50-K52 Noninfective enteritis and colitis
0.998 0.002 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.996 0.004 0.000
Chapter IX Diseases of the circulatory system
0.991 0.009 0.000
I60-I69 Cerebrovascular diseases
0.989 0.011 0.000
F41 Other anxiety disorders
0.989 0.011 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.987 0.013 0.000
J34 Other disorders of nose and nasal sinuses
0.987 0.013 0.000
K52 Other non-infective gastro-enteritis and colitis
0.983 0.017 0.000
Chapter I Certain infectious and parasitic diseases
0.980 0.020 0.000
K90-K93 Other diseases of the digestive system
0.978 0.022 0.000
K55-K64 Other diseases of intestines
0.977 0.023 0.000
M20 Acquired deformities of fingers and toes
0.975 0.025 0.000
K52.9 Non-infective gastro-enteritis and colitis, unspecified
0.973 0.027 0.000
K62 Other diseases of anus and rectum
0.972 0.028 0.000
Chapter VI Diseases of the nervous system
0.970 0.030 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.968 0.032 0.000
F41.2 Mixed anxiety and depressive disorder
0.963 0.037 0.000
M25 Other joint disorders, not elsewhere classified
0.963 0.037 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.957 0.043 0.000
M50-M54 Other dorsopathies
0.953 0.047 0.000
K62.3 Rectal prolapse
0.951 0.049 0.000
J34.2 Deviated nasal septum
0.947 0.053 0.000
B95-B98 Bacterial, viral and other infectious agents
0.943 0.057 0.000
F10 Mental and behavioural disorders due to use of alcohol
0.942 0.058 0.000
K90 Intestinal malabsorption
0.941 0.059 0.000
M20.2 Hallux rigidus
0.940 0.060 0.000
K50 Crohn's disease [regional enteritis]
0.938 0.062 0.000
M25.5 Pain in joint
0.934 0.066 0.000
K70-K77 Diseases of liver
0.931 0.069 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.931 0.069 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.930 0.070 0.000
J32 Chronic sinusitis
0.928 0.072 0.000
M54 Dorsalgia
0.926 0.074 0.000
K00-K14 Diseases of oral cavity, salivary glands and jaws
0.926 0.074 0.000
I64 Stroke, not specified as haemorrhage or infarction
0.926 0.074 0.000
K62.8 Other specified diseases of anus and rectum
0.923 0.077 0.000
J20-J22 Other acute lower respiratory infections
0.919 0.081 0.000
M54.5 Low back pain
0.917 0.083 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.911 0.089 0.000
K90.0 Coeliac disease
0.909 0.091 0.000
M25.56 Pain in joint (Lower leg)
0.907 0.093 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.905 0.095 0.000
M54.57 Low back pain (Lumbosacral region)
0.904 0.096 0.000
M22 Disorders of patella
0.901 0.099 0.000
I67 Other cerebrovascular diseases
0.901 0.099 0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters
0.900 0.100 0.000
J09-J18 Influenza and pneumonia
0.900 0.100 0.000
M70-M79 Other soft tissue disorders
0.898 0.102 0.000
F41.0 Panic disorder [episodic paroxysmal anxiety]
0.896 0.104 0.000
I05-I09 Chronic rheumatic heart diseases
0.892 0.108 0.000
T81 Complications of procedures, not elsewhere classified
0.892 0.108 0.000
I63 Cerebral infarction
0.891 0.109 0.000
S70-S79 Injuries to the hip and thigh
0.886 0.114 0.000
F10.1 Harmful use
0.886 0.114 0.000
K62.5 Haemorrhage of anus and rectum
0.884 0.116 0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis
0.881 0.119 0.000
M23 Internal derangement of knee
0.878 0.122 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.878 0.122 0.000
F10.3 Withdrawal state
0.876 0.124 0.000
J84 Other interstitial pulmonary diseases
0.872 0.128 0.000
F43 Reaction to severe stress, and adjustment disorders
0.869 0.131 0.000
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts
0.869 0.131 0.000
K51 Ulcerative colitis
0.867 0.133 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.866 0.134 0.000
F30-F39 Mood [affective] disorders
0.866 0.134 0.000
K08 Other disorders of teeth and supporting structures
0.866 0.134 0.000
J34.3 Hypertrophy of nasal turbinates
0.864 0.136 0.000
K50.0 Crohn's disease of small intestine
0.863 0.137 0.000
S60-S69 Injuries to the wrist and hand
0.862 0.138 0.000
J22 Unspecified acute lower respiratory infection
0.861 0.139 0.000
I60 Subarachnoid haemorrhage
0.861 0.139 0.000
G81 Hemiplegia
0.860 0.140 0.000
J38 Diseases of vocal cords and larynx, not elsewhere classified
0.855 0.145 0.000
J31 Chronic rhinitis, nasopharyngitis and pharyngitis
0.854 0.146 0.000
M25.57 Pain in joint (Ankle and foot)
0.854 0.146 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.854 0.146 0.000
B96 Other bacterial agents as the cause of diseases classified to other chapters
0.852 0.148 0.000
I67.9 Cerebrovascular disease, unspecified
0.851 0.149 0.000
J30 Vasomotor and allergic rhinitis
0.850 0.150 0.000
K76 Other diseases of liver
0.847 0.153 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.845 0.155 0.000
J32.9 Chronic sinusitis, unspecified
0.845 0.155 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.842 0.158 0.000
T79-T79 Certain early complications of trauma
0.839 0.161 0.000
J34.8 Other specified disorders of nose and nasal sinuses
0.838 0.162 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.837 0.163 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.834 0.166 0.000
J84.1 Other interstitial pulmonary diseases with fibrosis
0.834 0.166 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.833 0.167 0.000
M20.1 Hallux valgus (acquired)
0.832 0.168 0.000
Chapter XXII Codes for special purposes
0.831 0.169 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.830 0.170 0.000
M24 Other specific joint derangements
0.827 0.173 0.000
M40-M43 Deforming dorsopathies
0.827 0.173 0.000
F41.9 Anxiety disorder, unspecified
0.826 0.174 0.000
B35-B49 Mycoses
0.824 0.176 0.000
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts
0.823 0.176 0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.823 0.177 0.000
G81.9 Hemiplegia, unspecified
0.823 0.177 0.000
J60-J70 Lung diseases due to external agents
0.822 0.178 0.000
I05 Rheumatic mitral valve diseases
0.816 0.184 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.816 0.184 0.000
K62.6 Ulcer of anus and rectum
0.816 0.184 0.000
D50-D53 Nutritional anaemias
0.816 0.184 0.000
B95.6 Staphylococcus aureus as the cause of diseases classified to other chapters
0.816 0.184 0.000
S40-S49 Injuries to the shoulder and upper arm
0.815 0.185 0.000
K92 Other diseases of digestive system
0.812 0.188 0.000
M86-M90 Other osteopathies
0.809 0.191 0.000
S00-S09 Injuries to the head
0.809 0.191 0.000
R21 Rash and other nonspecific skin eruption
0.808 0.192 0.000
K76.0 Fatty (change of) liver, not elsewhere classified
0.808 0.192 0.000
B95.4 Other streptococcus as the cause of diseases classified to other chapters
0.806 0.194 0.000
K74 Fibrosis and cirrhosis of liver
0.805 0.195 0.000
K52.0 Gastro-enteritis and colitis due to radiation
0.796 0.204 0.000
M80-M85 Disorders of bone density and structure
0.795 0.205 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.795 0.205 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.794 0.206 0.000
M31 Other necrotising vasculopathies
0.793 0.207 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.791 0.209 0.000
T84.0 Mechanical complication of internal joint prosthesis
0.787 0.213 0.000
G90-G99 Other disorders of the nervous system
0.787 0.213 0.000
K91 Postprocedural disorders of digestive system, not elsewhere classified
0.786 0.214 0.000
M51 Other intervertebral disk disorders
0.785 0.215 0.000
K59 Other functional intestinal disorders
0.785 0.215 0.000
F19 Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances
0.784 0.216 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.784 0.216 0.000
M20.4 Other hammer toe(s) (acquired)
0.784 0.216 0.000
D69 Purpura and other haemorrhagic conditions
0.782 0.218 0.000
M34 Systemic sclerosis
0.782 0.218 0.000
J95-J99 Other diseases of the respiratory system
0.781 0.219 0.000
K05 Gingivitis and periodontal diseases
0.781 0.219 0.000
J32.0 Chronic maxillary sinusitis
0.780 0.220 0.000
I69 Sequelae of cerebrovascular disease
0.780 0.220 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.780 0.220 0.000
T84.2 Mechanical complication of internal fixation device of other bones
0.778 0.222 0.000
J35 Chronic diseases of tonsils and adenoids
0.778 0.222 0.000
F31 Bipolar affective disorder
0.777 0.223 0.000
Chapter XX External causes of morbidity and mortality
0.777 0.223 0.000
T81.4 Infection following a procedure, not elsewhere classified
0.776 0.224 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.775 0.225 0.000
T84.4 Mechanical complication of other internal orthopaedic devices, imnplants and grafts
0.775 0.225 0.000
M65-M68 Disorders of synovium and tendon
0.772 0.228 0.000
M22.2 Patellofemoral disorders
0.771 0.229 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.768 0.231 0.000
B65-B83 Helminthiases
0.767 0.233 0.000
B96.8 Other specified bacterial agents as the cause of diseases classified to other chapters
0.767 0.233 0.000
J34.0 Abscess, furuncle and carbuncle of nose
0.765 0.235 0.000
F40 Phobic anxiety disorders
0.765 0.235 0.000
K08.8 Other specified disorders of teeth and supporting structures
0.765 0.235 0.000
K51.3 Ulcerative (chronic) rectosigmoiditis
0.765 0.235 0.000
K65-K67 Diseases of peritoneum
0.764 0.236 0.000
D60-D64 Aplastic and other anaemias
0.763 0.237 0.000
A30-A49 Other bacterial diseases
0.762 0.238 0.000
K62.9 Disease of anus and rectum, unspecified
0.761 0.239 0.000
T84.3 Mechanical complication of other bone devices, implants and grafts
0.761 0.239 0.000
M54.58 Low back pain (Sacral and sacrococcygeal region)
0.761 0.239 0.000
J18 Pneumonia, organism unspecified
0.760 0.240 0.000
M05-M14 Inflammatory polyarthropathies
0.758 0.242 0.000
D51 Vitamin B12 deficiency anaemia
0.757 0.243 0.000
F12 Mental and behavioural disorders due to use of cannabinoids
0.757 0.243 0.000
M45-M49 Spondylopathies
0.755 0.245 0.000
Chapter VII Diseases of the eye and adnexa
0.755 0.245 0.000
A00-A09 Intestinal infectious diseases
0.753 0.247 0.000
M20.6 Acquired deformity of toe(s), unspecified
0.752 0.248 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.752 0.248 0.000
M77 Other enthesopathies
0.751 0.249 0.000
D69.6 Thrombocytopenia, unspecified
0.751 0.249 0.000
J31.0 Chronic rhinitis
0.751 0.249 0.000
K12 Stomatitis and related lesions
0.750 0.250 0.000
K08.3 Retained dental root
0.749 0.251 0.000
M23.3 Other meniscus derangements
0.749 0.251 0.000
J13 Pneumonia due to Streptococcus pneumoniae
0.748 0.252 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.747 0.252 0.000
K50.9 Crohn's disease, unspecified
0.747 0.253 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.747 0.253 0.000
M54.59 Low back pain (Site unspecified)
0.746 0.254 0.000
M25.9 Joint disorder, unspecified
0.746 0.254 0.000
T81.1 Shock during or resulting from a procedure, not elsewhere classified
0.745 0.255 0.000
T66-T78 Other and unspecified effects of external causes
0.744 0.256 0.000
J30.1 Allergic rhinitis due to pollen
0.744 0.256 0.000
M79.8 Other specified soft tissue disorders
0.743 0.257 0.000
M91-M94 Chondropathies
0.743 0.257 0.000
I63.5 Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
0.742 0.258 0.000
K13 Other diseases of lip and oral mucosa
0.741 0.259 0.000
T85.5 Mechanical complication of gastro-intestinal prosthetic devices, implants and grafts
0.739 0.261 0.000
T84.6 Infection and inflammatory reaction due to internal fixation device [any site]
0.738 0.262 0.000
O26 Maternal care for other conditions predominantly related to pregnancy
0.738 0.262 0.000
S79 Other and unspecified injuries of hip and thigh
0.736 0.264 0.000
Q60-Q64 Congenital malformations of the urinary system
0.736 0.264 0.000
M21 Other acquired deformities of limbs
0.736 0.264 0.000
I05.9 Mitral valve disease, unspecified
0.735 0.265 0.000
I63.9 Cerebral infarction, unspecified
0.735 0.265 0.000
S72 Fracture of femur
0.734 0.265 0.000
M54.4 Lumbago with sciatica
0.734 0.266 0.000
G70-G73 Diseases of myoneural junction and muscle
0.732 0.268 0.000
F43.2 Adjustment disorders
0.731 0.269 0.000
S61 Open wound of wrist and hand
0.730 0.270 0.000
K92.0 Haematemesis
0.729 0.271 0.000
O32 Maternal care for known or suspected malpresentation of foetus
0.728 0.272 0.000
G30-G32 Other degenerative diseases of the nervous system
0.727 0.273 0.000
F10.4 Withdrawal state with delirium
0.726 0.274 0.000
M00-M03 Infectious arthropathies
0.726 0.274 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.726 0.274 0.000
J38.1 Polyp of vocal cord and larynx
0.725 0.275 0.000
K90.9 Intestinal malabsorption, unspecified
0.724 0.276 0.000
M22.8 Other disorders of patella
0.724 0.276 0.000
T79 Certain early complications of trauma, not elsewhere classified
0.723 0.277 0.000
Q80-Q89 Other congenital malformations
0.722 0.277 0.000
J18.9 Pneumonia, unspecified
0.721 0.279 0.000
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.720 0.280 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.717 0.283 0.000
I71 Aortic aneurysm and dissection
0.717 0.283 0.000
M60-M63 Disorders of muscles
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
I61 Intracerebral haemorrhage
0.717 0.283 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.717 0.283 0.000
M33 Dermatopolymyositis
0.717 0.283 0.000
M32 Systemic lupus erythematosus
0.717 0.283 0.000
M30 Polyarteritis nodosa and related conditions
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.717 0.283 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
S10-S19 Injuries to the neck
0.717 0.283 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.717 0.283 0.000
F80-F89 Disorders of psychological development
0.717 0.283 0.000
F70-F79 Mental retardation
0.717 0.283 0.000
F60-F69 Disorders of adult personality and behaviour
0.717 0.283 0.000
S64 Injury of nerves at wrist and hand level
0.716 0.284 0.000
T87 Complications peculiar to reattachment and amputation
0.716 0.284 0.000
T86 Failure and rejection of transplanted organs and tissues
0.716 0.284 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.716 0.284 0.000
T84.1 Mechanical complication of internal fixation device of bones of limb
0.716 0.284 0.000
J37 Chronic laryngitis and laryngotracheitis
0.715 0.284 0.000
K75 Other inflammatory liver diseases
0.715 0.285 0.000
F48 Other neurotic disorders
0.714 0.286 0.000
F44 Dissociative [conversion] disorders
0.714 0.286 0.000
F42 Obsessive-compulsive disorder
0.714 0.286 0.000
I60.9 Subarachnoid haemorrhage, unspecified
0.712 0.288 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.712 0.288 0.000
J81 Pulmonary oedema
0.711 0.289 0.000
I00-I02 Acute rheumatic fever
0.711 0.289 0.000
I60.3 Subarachnoid haemorrhage from posterior communicating artery
0.710 0.290 0.000
M25.52 Pain in joint (Upper arm)
0.709 0.291 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.709 0.291 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.709 0.291 0.000
F41.8 Other specified anxiety disorders
0.709 0.291 0.000
F41.3 Other mixed anxiety disorders
0.709 0.291 0.000
F41.1 Generalised anxiety disorder
0.709 0.291 0.000
T84.9 Unspecified complication of internal orthopaedic prosthetic device, implant and graft
0.708 0.292 0.000
J34.1 Cyst and mucocele of nose and nasal sinus
0.708 0.292 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.708 0.292 0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems
0.707 0.293 0.000
T81.0 Haemorrhage and haematoma complicating a procedure, not elsewhere classified
0.706 0.294 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.706 0.294 0.000
K40-K46 Hernia
0.705 0.295 0.000
K52.3 Indeterminate colitis
0.704 0.295 0.000
K52.2 Allergic and dietetic gastro-enteritis and colitis
0.704 0.295 0.000
K52.1 Toxic gastro-enteritis and colitis
0.704 0.295 0.000
I65.2 Occlusion and stenosis of carotid artery
0.704 0.296 0.000
S20-S29 Injuries to the thorax
0.703 0.296 0.000
B96.1 Klebsiella pneumoniae [K. pneumoniae] as the cause of diseases classified to other chapters
0.703 0.297 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.703 0.297 0.000
M54.2 Cervicalgia
0.703 0.297 0.000
B99-B99 Other infectious diseases
0.702 0.298 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.702 0.298 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.702 0.298 0.000
B50-B64 Protozoal diseases
0.702 0.298 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.702 0.298 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.702 0.298 0.000
A80-A89 Viral infections of the central nervous system
0.702 0.298 0.000
A75-A79 Rickettsioses
0.702 0.298 0.000
A70-A74 Other diseases caused by chlamydiae
0.702 0.298 0.000
A65-A69 Other spirochaetal diseases
0.702 0.298 0.000
A20-A28 Certain zoonotic bacterial diseases
0.702 0.298 0.000
A15-A19 Tuberculosis
0.702 0.298 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.702 0.298 0.000
F45 Somatoform disorders
0.702 0.298 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.702 0.298 0.000
K93 Disorders of other digestive organs in diseases classified elsewhere
0.701 0.298 0.000
G82 Paraplegia and tetraplegia
0.701 0.299 0.000
S01 Open wound of head
0.701 0.299 0.000
K50.8 Other Crohn's disease
0.701 0.299 0.000
M22.4 Chondromalacia patellae
0.701 0.299 0.000
K64 Haemorrhoids and perianal venous thrombosis
0.700 0.299 0.000
F99-F99 Unspecified mental disorder
0.699 0.300 0.000
I63.8 Other cerebral infarction
0.699 0.301 0.000
M51.0 Lumbar and other intervertebral disk disorders with myelopathy
0.699 0.301 0.000
K62.2 Anal prolapse
0.697 0.303 0.000
I67.8 Other specified cerebrovascular diseases
0.697 0.303 0.000
T88.7 Unspecified adverse effect of drug or medicament
0.697 0.303 0.000
K50.1 Crohn's disease of large intestine
0.695 0.304 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.695 0.305 0.000
F18 Mental and behavioural disorders due to use of volatile solvents
0.694 0.306 0.000
F16 Mental and behavioural disorders due to use of hallucinogens
0.694 0.306 0.000
F15 Mental and behavioural disorders due to use of other stimulants, including caffeine
0.694 0.306 0.000
F14 Mental and behavioural disorders due to use of cocaine
0.694 0.306 0.000
F13 Mental and behavioural disorders due to use of sedatives or hypnotics
0.694 0.306 0.000
F11 Mental and behavioural disorders due to use of opioids
0.694 0.306 0.000
T85.6 Mechanical complication of other specified internal prosthetic devices, implants and grafts
0.694 0.306 0.000
J38.4 Oedema of larynx
0.693 0.307 0.000
M23.5 Chronic instability of knee
0.691 0.309 0.000
M25.8 Other specified joint disorders
0.690 0.310 0.000
M25.3 Other instability of joint
0.690 0.310 0.000
M25.2 Flail joint
0.690 0.310 0.000
M25.1 Fistula of joint
0.690 0.310 0.000
M25.0 Haemarthrosis
0.690 0.310 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.689 0.310 0.000
G51 Facial nerve disorders
0.689 0.311 0.000
B95.2 Streptococcus, group D, as the cause of diseases classified to other chapters
0.688 0.312 0.000
R23 Other skin changes
0.688 0.312 0.000
T88.6 Anaphylactic shock due to adverse effect of correct drug or medicament properly administered
0.688 0.312 0.000
O85-O92 Complications predominantly related to the puerperium
0.686 0.313 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.685 0.315 0.000
D80-D89 Certain disorders involving the immune mechanism
0.685 0.315 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.685 0.315 0.000
M23.33 Other meniscus derangements (Medial collateral ligament or Other and unspecified medial meniscus)
0.684 0.316 0.000
M23.2 Derangement of meniscus due to old tear or injury
0.684 0.316 0.000
J69 Pneumonitis due to solids and liquids
0.684 0.316 0.000
M79.6 Pain in limb
0.684 0.316 0.000
J14 Pneumonia due to Haemophilus influenzae
0.683 0.317 0.000
M53 Other dorsopathies, not elsewhere classified
0.683 0.317 0.000
O43 Placental disorders
0.683 0.317 0.000
M24.2 Disorder of ligament
0.683 0.317 0.000
K60 Fissure and fistula of anal and rectal regions
0.683 0.317 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.682 0.317 0.000
G20-G26 Extrapyramidal and movement disorders
0.682 0.318 0.000
S60 Superficial injury of wrist and hand
0.681 0.319 0.000
K10 Other diseases of jaws
0.680 0.320 0.000
B95.1 Streptococcus, group B, as the cause of diseases classified to other chapters
0.679 0.321 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.679 0.321 0.000
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium
0.679 0.321 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.679 0.321 0.000
O80-O84 Delivery
0.678 0.322 0.000
T88.4 Failed or difficult intubation
0.677 0.323 0.000
I62 Other nontraumatic intracranial haemorrhage
0.677 0.323 0.000
F10.2 Dependence syndrome
0.676 0.324 0.000
K14 Diseases of tongue
0.675 0.325 0.000
F10.9 Unspecified mental and behavioural disorder
0.675 0.325 0.000
F10.8 Other mental and behavioural disorders
0.675 0.325 0.000
F10.7 Residual and late-onset psychotic disorder
0.675 0.325 0.000
F10.6 Amnesic syndrome
0.675 0.325 0.000
F10.5 Psychotic disorder
0.675 0.325 0.000
K90.8 Other intestinal malabsorption
0.675 0.325 0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.675 0.325 0.000
K90.3 Pancreatic steatorrhoea
0.675 0.325 0.000
K90.2 Blind loop syndrome, not elsewhere classified
0.675 0.325 0.000
K90.1 Tropical sprue
0.675 0.325 0.000
K61 Abscess of anal and rectal regions
0.674 0.326 0.000
F43.0 Acute stress reaction
0.673 0.326 0.000
M20.0 Deformity of finger(s)
0.673 0.327 0.000
K51.2 Ulcerative (chronic) proctitis
0.673 0.327 0.000
T85.9 Unspecified complication of internal prosthetic device, implant and graft
0.673 0.327 0.000
K59.8 Other specified functional intestinal disorders
0.672 0.328 0.000
Q00-Q07 Congenital malformations of the nervous system
0.672 0.328 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.672 0.328 0.000
B15-B19 Viral hepatitis
0.672 0.328 0.000
K07 Dentofacial anomalies [including malocclusion]
0.670 0.329 0.000
K55 Vascular disorders of intestine
0.670 0.330 0.000
M25.59 Pain in joint (Site unspecified)
0.670 0.330 0.000
M25.58 Pain in joint (Other)
0.670 0.330 0.000
B95.3 Streptococcus pneumoniae as the cause of diseases classified to other chapters
0.669 0.331 0.000
S50-S59 Injuries to the elbow and forearm
0.669 0.331 0.000
I74 Arterial embolism and thrombosis
0.668 0.331 0.000
B25-B34 Other viral diseases
0.668 0.332 0.000
S90-S99 Injuries to the ankle and foot
0.668 0.332 0.000
K77 Liver disorders in diseases classified elsewhere
0.668 0.332 0.000
K73 Chronic hepatitis, not elsewhere classified
0.668 0.332 0.000
K71 Toxic liver disease
0.668 0.332 0.000
T90 Sequelae of injuries of head
0.668 0.332 0.000
J82 Pulmonary eosinophilia, not elsewhere classified
0.668 0.332 0.000
J80 Adult respiratory distress syndrome
0.668 0.332 0.000
B37 Candidiasis
0.668 0.332 0.000
D55-D59 Haemolytic anaemias
0.667 0.333 0.000
F43.1 Posttraumatic stress disorder
0.667 0.333 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.666 0.334 0.000
O16 Unspecified maternal hypertension
0.666 0.334 0.000
J32.4 Chronic pansinusitis
0.665 0.334 0.000
J32.3 Chronic sphenoidal sinusitis
0.665 0.334 0.000
J32.1 Chronic frontal sinusitis
0.665 0.334 0.000
M54.8 Other dorsalgia
0.664 0.336 0.000
M54.6 Pain in thoracic spine
0.664 0.336 0.000
M54.0 Panniculitis affecting regions of neck and back
0.664 0.336 0.000
K03 Other diseases of hard tissues of teeth
0.664 0.336 0.000
K00 Disorders of tooth development and eruption
0.664 0.336 0.000
O36 Maternal care for other known or suspected foetal problems
0.664 0.336 0.000
J32.2 Chronic ethmoidal sinusitis
0.664 0.336 0.000
R94 Abnormal results of function studies
0.664 0.336 0.000
M25.7 Osteophyte
0.662 0.337 0.000
M25.55 Pain in joint (Pelvic region and thigh)
0.662 0.338 0.000
K05.3 Chronic periodontitis
0.662 0.338 0.000
T81.3 Disruption of operation wound, not elsewhere classified
0.661 0.339 0.000
O00-O08 Pregnancy with abortive outcome
0.661 0.339 0.000
K56 Paralytic ileus and intestinal obstruction without hernia
0.661 0.339 0.000
M41 Scoliosis
0.661 0.339 0.000
I05.0 Mitral stenosis
0.661 0.339 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.661 0.339 0.000
K04 Diseases of pulp and periapical tissues
0.660 0.339 0.000
F31.2 Bipolar affective disorder, current episode manic with psychotic symptoms
0.660 0.340 0.000
S70 Superficial injury of hip and thigh
0.660 0.340 0.000
K62.4 Stenosis of anus and rectum
0.660 0.340 0.000
Q50-Q56 Congenital malformations of genital organs
0.659 0.341 0.000
J35.1 Hypertrophy of tonsils
0.659 0.341 0.000
M25.4 Effusion of joint
0.659 0.341 0.000
O41 Other disorders of amniotic fluid and membranes
0.659 0.341 0.000
B44 Aspergillosis
0.659 0.341 0.000
J21 Acute bronchiolitis
0.659 0.341 0.000
J20 Acute bronchitis
0.659 0.341 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.659 0.341 0.000
M71 Other bursopathies
0.658 0.342 0.000
B96.4 Proteus (mirabilis)(morganii) as the cause of diseases classified to other chapters
0.658 0.342 0.000
M54.55 Low back pain (Thoracolumbar region)
0.658 0.342 0.000
M54.54 Low back pain-Thoracic
0.658 0.342 0.000
M54.53 Low back pain-Cervicothoracic
0.658 0.342 0.000
M54.52 Low back pain-Cervical
0.658 0.342 0.000
M54.51 Low back pain-Occipit-atl-axl
0.658 0.342 0.000
M54.50 Low back pain (Multiple sites in spine)
0.658 0.342 0.000
M25.50 Pain in joint (Multiple sites)
0.657 0.343 0.000
K74.3 Primary biliary cirrhosis
0.657 0.343 0.000
K72 Hepatic failure, not elsewhere classified
0.657 0.343 0.000
K09 Cysts of oral region, not elsewhere classified
0.657 0.343 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.657 0.343 0.000
O35 Maternal care for known or suspected foetal abnormality and damage
0.657 0.343 0.000
K91.8 Other postprocedural disorders of digestive system, not elsewhere classified
0.656 0.344 0.000
R25 Abnormal involuntary movements
0.655 0.345 0.000
M79.1 Myalgia
0.654 0.346 0.000
M23.6 Other spontaneous disruption of ligament(s) of knee
0.654 0.346 0.000
G80 Infantile cerebral palsy
0.653 0.347 0.000
F19.1 Harmful use
0.653 0.347 0.000
S49 Other and unspecified injuries of shoulder and upper arm
0.653 0.347 0.000
K92.1 Melaena
0.653 0.347 0.000
I08 Multiple valve diseases
0.652 0.348 0.000
M43 Other deforming dorsopathies
0.652 0.348 0.000
I72 Other aneurysm
0.652 0.348 0.000
F31.1 Bipolar affective disorder, current episode manic without psychotic symptoms
0.651 0.349 0.000
M23.26 Derangement of meniscus due to old tear or injury (Other and unspecified lateral meniscus)
0.651 0.349 0.000
G83 Other paralytic syndromes
0.651 0.349 0.000
J32.8 Other chronic sinusitis
0.651 0.349 0.000
M81 Osteoporosis without pathological fracture
0.651 0.349 0.000
K74.6 Other and unspecified cirrhosis of liver
0.650 0.350 0.000
M67 Other disorders of synovium and tendon
0.650 0.350 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.649 0.351 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.649 0.351 0.000
Q35-Q37 Cleft lip and cleft palate
0.649 0.351 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.649 0.351 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.649 0.351 0.000
B95.7 Other staphylococcus as the cause of diseases classified to other chapters
0.648 0.352 0.000
M22.1 Recurrent subluxation of patella
0.646 0.354 0.000
M22.9 Disorder of patella, unspecified
0.646 0.354 0.000
M22.3 Other derangements of patella
0.646 0.354 0.000
M22.0 Recurrent dislocation of patella
0.646 0.354 0.000
I67.7 Cerebral arteritis, not elsewhere classified
0.646 0.354 0.000
I67.6 Nonpyogenic thrombosis of intracranial venous system
0.646 0.354 0.000
I67.5 Moyamoya disease
0.646 0.354 0.000
I67.4 Hypertensive encephalopathy
0.646 0.354 0.000
I67.3 Progressive vascular leukoencephalopathy
0.646 0.354 0.000
I67.0 Dissection of cerebral arteries, nonruptured
0.646 0.354 0.000
S42 Fracture of shoulder and upper arm
0.646 0.354 0.000
B95.0 Streptococcus, group A, as the cause of diseases classified to other chapters
0.646 0.354 0.000
J17 Pneumonia in diseases classified elsewhere
0.645 0.354 0.000
J16 Pneumonia due to other infectious organisms, not elsewhere classified
0.645 0.354 0.000
J15 Bacterial pneumonia, not elsewhere classified
0.645 0.354 0.000
J12 Viral pneumonia, not elsewhere classified
0.645 0.354 0.000
J11 Influenza, virus not identified
0.645 0.354 0.000
J10 Influenza due to identified influenza virus
0.645 0.354 0.000
J09 Influenza due to certain identified influenza virus
0.645 0.354 0.000
I07 Rheumatic tricuspid valve diseases
0.645 0.355 0.000
M31.6 Other giant cell arteritis
0.645 0.355 0.000
M76 Enthesopathies of lower limb, excluding foot
0.644 0.356 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.644 0.356 0.000
G93 Other disorders of brain
0.644 0.356 0.000
S62 Fracture at wrist and hand level
0.643 0.357 0.000
K08.1 Loss of teeth due to accident, extraction or local periodontal disease
0.643 0.357 0.000
J38.7 Other diseases of larynx
0.642 0.358 0.000
M95 Other acquired deformities of musculoskeletal system and connective tissue
0.642 0.358 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.641 0.359 0.000
T79.3 Post-traumatic wound infection, not elsewhere classified
0.641 0.359 0.000
S30 Superficial injury of abdomen, lower back and pelvis
0.640 0.360 0.000
I09 Other rheumatic heart diseases
0.640 0.360 0.000
I06 Rheumatic aortic valve diseases
0.640 0.360 0.000
T81.9 Unspecified complication of procedure
0.640 0.360 0.000
T81.7 Vascular complications following a procedure, not elsewhere classified
0.640 0.360 0.000
T81.6 Acute reaction to foreign substance accidentally left during a procedure
0.640 0.360 0.000
M24.8 Other specific joint derangements, not elsewhere classified
0.639 0.361 0.000
I63.6 Cerebral infarction due to cerebral venous thrombosis, nonpyogenic
0.639 0.361 0.000
I63.4 Cerebral infarction due to embolism of cerebral arteries
0.639 0.361 0.000
I63.3 Cerebral infarction due to thrombosis of cerebral arteries
0.639 0.361 0.000
I63.2 Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
0.639 0.361 0.000
I63.1 Cerebral infarction due to embolism of precerebral arteries
0.639 0.361 0.000
I63.0 Cerebral infarction due to thrombosis of precerebral arteries
0.639 0.361 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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