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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs1311915
log Bayes Factor = 48.2818
Chromosome 6   position 28,742,340  (GRCh37) Explore rs1311915 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10.9 Without complications
0.000 0.001 0.999
E10.3 With ophthalmic complications
0.000 0.003 0.997
E10.1 With ketoacidosis
0.000 0.048 0.952
E10.2 With renal complications
0.000 0.056 0.944
E10-E14 Diabetes mellitus
0.000 0.085 0.915
E05.9 Thyrotoxicosis, unspecified
0.000 0.089 0.911
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.107 0.893
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.109 0.891
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.112 0.888
E16 Other disorders of pancreatic internal secretion
0.000 0.113 0.887
E16.2 Hypoglycaemia, unspecified
0.000 0.114 0.886
E00-E07 Disorders of thyroid gland
0.000 0.121 0.879
E10.4 With neurological complications
0.000 0.127 0.873
E40-E46 Malnutrition
0.000 0.224 0.776
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.235 0.765
E10.0 With coma
0.000 0.252 0.748
E05.8 Other thyrotoxicosis
0.000 0.256 0.744
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.274 0.726
E10.7 With multiple complications
0.000 0.300 0.699
E46 Unspecified protein-energy malnutrition
0.000 0.307 0.693
E10.6 With other specified complications
0.000 0.334 0.666
E12 Malnutrition-related diabetes mellitus
0.000 0.344 0.656
E13 Other specified diabetes mellitus
0.000 0.354 0.646
E05.5 Thyroid crisis or storm
0.000 0.359 0.640
E05.4 Thyrotoxicosis factitia
0.000 0.359 0.640
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.359 0.640
E15 Nondiabetic hypoglycaemic coma
0.000 0.363 0.637
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.364 0.636
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.364 0.636
E16.4 Abnormal secretion of gastrin
0.000 0.364 0.636
E16.3 Increased secretion of glucagon
0.000 0.364 0.636
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.370 0.630
E00 Congenital iodine-deficiency syndrome
0.000 0.370 0.630
E14 Unspecified diabetes mellitus
0.000 0.379 0.621
E16.1 Other hypoglycaemia
0.000 0.381 0.619
E10.5 With peripheral circulatory complications
0.000 0.390 0.610
E06 Thyroiditis
0.000 0.412 0.588
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.424 0.576
E10.8 With unspecified complications
0.000 0.430 0.570
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.444 0.556
E45 Retarded development following protein-energy malnutrition
0.000 0.444 0.556
E43 Unspecified severe protein-energy malnutrition
0.000 0.444 0.556
E42 Marasmic kwashiorkor
0.000 0.444 0.556
E41 Nutritional marasmus
0.000 0.444 0.556
E40 Kwashiorkor
0.000 0.444 0.556
E14.3 With ophthalmic complications
0.000 0.447 0.553
E07 Other disorders of thyroid
0.000 0.453 0.547
E14.1 With ketoacidosis
0.000 0.491 0.509
E06.9 Thyroiditis, unspecified
0.000 0.494 0.506
E14.6 With other specified complications
0.000 0.520 0.480
E13.3 With ophthalmic complications
0.000 0.527 0.472
E12.9 Without complications
0.000 0.530 0.470
E12.8 With unspecified complications
0.000 0.530 0.470
E12.7 With multiple complications
0.000 0.530 0.470
E12.6 With other specified complications
0.000 0.530 0.470
E12.5 With peripheral circulatory complications
0.000 0.530 0.470
E12.4 With neurological complications
0.000 0.530 0.470
E12.3 With ophthalmic complications
0.000 0.530 0.470
E12.2 With renal complications
0.000 0.530 0.470
E12.1 With ketoacidosis
0.000 0.530 0.470
E12.0 With coma
0.000 0.530 0.470
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.530 0.469
E13.8 With unspecified complications
0.000 0.537 0.463
E13.7 With multiple complications
0.000 0.537 0.463
E13.6 With other specified complications
0.000 0.537 0.463
E13.5 With peripheral circulatory complications
0.000 0.537 0.463
E13.4 With neurological complications
0.000 0.537 0.463
E13.2 With renal complications
0.000 0.537 0.463
E13.1 With ketoacidosis
0.000 0.537 0.463
E13.0 With coma
0.000 0.537 0.463
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.548 0.452
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.548 0.452
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.548 0.452
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.548 0.452
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.548 0.452
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.548 0.452
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.548 0.452
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.548 0.452
E14.7 With multiple complications
0.000 0.555 0.445
E13.9 Without complications
0.000 0.557 0.443
E14.2 Withrenal complications
0.000 0.568 0.432
E06.1 Subacute thyroiditis
0.000 0.570 0.430
E14.8 With unspecified complications
0.000 0.574 0.426
E06.4 Drug-induced thyroiditis
0.000 0.578 0.422
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.578 0.422
E06.0 Acute thyroiditis
0.000 0.578 0.422
E14.0 With coma
0.000 0.580 0.420
E07.8 Other specified disorders of thyroid
0.000 0.588 0.412
E14.5 With peripheral circulatory complications
0.000 0.589 0.411
E06.5 Other chronic thyroiditis
0.000 0.590 0.410
E44.1 Mild protein-energy malnutrition
0.000 0.601 0.399
E44.0 Moderate protein-energy malnutrition
0.000 0.601 0.399
E07.1 Dyshormogenetic goitre
0.000 0.608 0.392
E07.0 Hypersecretion of calcitonin
0.000 0.608 0.392
E14.4 With neurological complications
0.000 0.615 0.385
E50-E64 Other nutritional deficiencies
0.000 0.628 0.372
E11 Non-insulin-dependent diabetes mellitus
0.000 0.636 0.364
C15 Malignant neoplasm of oesophagus
0.000 0.642 0.358
C20 Malignant neoplasm of rectum
0.000 0.648 0.352
C19 Malignant neoplasm of rectosigmoid junction
0.000 0.649 0.351
C15-C26 Malignant neoplasms of digestive organs
0.000 0.649 0.351
C15.9 Oesophagus, unspecified
0.000 0.661 0.339
E11.6 With other specified complications
0.000 0.666 0.334
E11.1 With ketoacidosis
0.000 0.666 0.334
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.001 0.670 0.329
C15.5 Lower third of oesophagus
0.000 0.671 0.329
K90 Intestinal malabsorption
0.000 0.679 0.321
C15.4 Middle third of oesophagus
0.000 0.686 0.314
C17 Malignant neoplasm of small intestine
0.000 0.700 0.300
C15.0 Cervical part of oesophagus
0.000 0.703 0.297
C17.0 Duodenum
0.000 0.711 0.289
C15.3 Upper third of oesophagus
0.000 0.713 0.287
E54 Ascorbic acid deficiency
0.000 0.717 0.283
E07.9 Disorder of thyroid, unspecified
0.000 0.726 0.274
E51 Thiamine deficiency
0.000 0.732 0.268
E11.2 With renal complications
0.000 0.732 0.268
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.733 0.266
E63 Other nutritional deficiencies
0.000 0.733 0.266
E50 Vitamin A deficiency
0.000 0.733 0.266
E60 Dietary zinc deficiency
0.000 0.733 0.266
E59 Dietary selenium deficiency
0.000 0.733 0.266
E52 Niacin deficiency [pellagra]
0.000 0.733 0.266
E11.0 With coma
0.000 0.734 0.266
C15.1 Thoracic part of oesophagus
0.000 0.737 0.263
E11.7 With multiple complications
0.000 0.739 0.261
C25 Malignant neoplasm of pancreas
0.000 0.739 0.261
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.000 0.742 0.258
C15.8 Overlapping lesion of oesophagus
0.000 0.743 0.257
C15.2 Abdominal part of oesophagus
0.000 0.743 0.257
E65-E68 Obesity and other hyperalimentation
0.000 0.745 0.255
E56 Other vitamin deficiencies
0.000 0.745 0.254
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.753 0.247
E03 Other hypothyroidism
0.000 0.754 0.246
E58 Dietary calcium deficiency
0.000 0.764 0.236
E53 Deficiency of other B group vitamins
0.000 0.765 0.235
E11.8 With unspecified complications
0.000 0.768 0.232
C21 Malignant neoplasm of anus and anal canal
0.000 0.768 0.231
K90.3 Pancreatic steatorrhoea
0.000 0.769 0.230
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.769 0.230
K90.1 Tropical sprue
0.000 0.769 0.230
C24.0 Extrahepatic bile duct
0.000 0.772 0.228
K90.8 Other intestinal malabsorption
0.000 0.773 0.227
E55 Vitamin D deficiency
0.000 0.773 0.227
C25.2 Tail of pancreas
0.000 0.783 0.217
C17.8 Overlapping lesion of small intestine
0.000 0.785 0.215
C17.3 Meckel's diverticulum
0.000 0.785 0.215
C25.3 Pancreatic duct
0.000 0.792 0.208
C25.1 Body of pancreas
0.000 0.794 0.206
C22 Malignant neoplasm of liver and intrahepatic bile ducts
0.000 0.795 0.205
C25.8 Overlapping lesion of pancreas
0.000 0.795 0.205
C25.4 Endocrine pancreas
0.000 0.796 0.204
C17.1 Jejunum
0.000 0.803 0.197
E61 Deficiency of other nutrient elements
0.000 0.803 0.197
E53.9 Vitamin B deficiency, unspecified
0.000 0.804 0.196
E11.5 With peripheral circulatory complications
0.000 0.805 0.195
E51.2 Wernicke's encephalopathy
0.000 0.806 0.194
E51.9 Thiamine deficiency, unspecified
0.000 0.807 0.192
E51.8 Other manifestations of thiamine deficiency
0.000 0.807 0.192
E51.1 Beriberi
0.000 0.807 0.192
E50.9 Vitamin A deficiency, unspecified
0.000 0.809 0.191
E50.8 Other manifestations of vitamin A deficiency
0.000 0.809 0.191
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.809 0.191
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.809 0.191
E50.5 Vitamin A deficiency with night blindness
0.000 0.809 0.191
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.809 0.191
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.809 0.191
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.809 0.191
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.809 0.191
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.809 0.191
E63.9 Nutritional deficiency, unspecified
0.000 0.809 0.191
E63.8 Other specified nutritional deficiencies
0.000 0.809 0.191
E63.1 Imbalance of constituents of food intake
0.000 0.809 0.191
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.809 0.191
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.809 0.191
E64.8 Sequelae of other nutritional deficiencies
0.000 0.809 0.191
E64.3 Sequelae of rickets
0.000 0.809 0.191
E64.2 Sequelae of vitamin C deficiency
0.000 0.809 0.191
E64.1 Sequelae of vitamin A deficiency
0.000 0.809 0.191
E64.0 Sequelae of protein-energy malnutrition
0.000 0.809 0.191
M45.X9 Ankylosing spondylitis (Site unspecified)
0.188 0.812 0.000
C24.8 Overlapping lesion of biliary tract
0.000 0.815 0.185
E67 Other hyperalimentation
0.000 0.817 0.183
E68 Sequelae of hyperalimentation
0.000 0.817 0.183
C21.8 Overlapping lesion of rectum, anus and anal canal
0.000 0.817 0.183
E56.9 Vitamin deficiency, unspecified
0.000 0.817 0.182
E56.8 Deficiency of other vitamins
0.000 0.817 0.182
E56.0 Deficiency of vitamin E
0.000 0.817 0.182
C17.9 Small intestine, unspecified
0.000 0.819 0.181
C24.9 Biliary tract, unspecified
0.000 0.819 0.181
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.821 0.179
C23 Malignant neoplasm of gallbladder
0.000 0.821 0.179
E03.5 Myxoedema coma
0.000 0.823 0.177
E03.4 Atrophy of thyroid (acquired)
0.000 0.823 0.177
E03.3 Postinfectious hypothyroidism
0.000 0.823 0.177
C25.9 Pancreas, unspecified
0.000 0.826 0.174
E06.3 Autoimmune thyroiditis
0.000 0.826 0.173
C26 Malignant neoplasm of other and ill-defined digestive organs
0.000 0.828 0.172
E56.1 Deficiency of vitamin K
0.000 0.829 0.170
E53.1 Pyridoxine deficiency
0.000 0.831 0.169
E53.0 Riboflavin deficiency
0.000 0.831 0.169
C21.2 Cloacogenic zone
0.000 0.834 0.166
E03.1 Congenital hypothyroidism without goitre
0.000 0.835 0.165
E55.0 Rickets, active
0.000 0.837 0.163
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.837 0.162
C22.1 Intrahepatic bile duct carcinoma
0.000 0.842 0.158
C25.7 Other parts of pancreas
0.000 0.843 0.157
C22.9 Liver, unspecified
0.000 0.848 0.152
E03.8 Other specified hypothyroidism
0.000 0.849 0.150
K90.9 Intestinal malabsorption, unspecified
0.000 0.851 0.148
C22.7 Other specified carcinomas of liver
0.000 0.853 0.147
C22.4 Other sarcomas of liver
0.000 0.853 0.147
C22.3 Angiosarcoma of liver
0.000 0.853 0.147
C22.2 Hepatoblastoma
0.000 0.853 0.147
C21.0 Anus, unspecified
0.000 0.853 0.147
C21.1 Anal canal
0.000 0.857 0.143
E61.9 Deficiency of nutrient element, unspecified
0.000 0.859 0.141
E61.8 Deficiency of other specified nutrient elements
0.000 0.859 0.141
E61.7 Deficiency of multiple nutrient elements
0.000 0.859 0.141
E61.6 Vanadium deficiency
0.000 0.859 0.141
E61.5 Molybdenum deficiency
0.000 0.859 0.141
E61.4 Chromium deficiency
0.000 0.859 0.141
E61.3 Manganese deficiency
0.000 0.859 0.141
E61.0 Copper deficiency
0.000 0.859 0.141
E14.9 Without complications
0.000 0.863 0.137
C17.2 Ileum
0.000 0.863 0.136
C16 Malignant neoplasm of stomach
0.000 0.864 0.136
E67.8 Other specified hyperalimentation
0.000 0.868 0.131
E67.3 Hypervitaminosis D
0.000 0.868 0.131
E67.2 Megavitamin-B6 syndrome
0.000 0.868 0.131
E67.1 Hypercarotenaemia
0.000 0.868 0.131
E67.0 Hypervitaminosis A
0.000 0.868 0.131
E61.2 Magnesium deficiency
0.000 0.872 0.128
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.128 0.872 0.000
C26.8 Overlapping lesion of digestive system
0.000 0.876 0.123
C26.1 Spleen
0.000 0.876 0.123
E55.9 Vitamin D deficiency, unspecified
0.000 0.877 0.123
C16.0 Cardia
0.000 0.882 0.118
E65 Localised adiposity
0.000 0.883 0.116
E11.4 With neurological complications
0.000 0.887 0.113
E83 Disorders of mineral metabolism
0.079 0.893 0.028
C24.1 Ampulla of Vater
0.001 0.896 0.103
M45 Ankylosing spondylitis
0.102 0.898 0.000
C16.2 Body of stomach
0.000 0.904 0.096
E61.1 Iron deficiency
0.000 0.904 0.095
C26.0 Intestinal tract, part unspecified
0.000 0.905 0.095
C16.6 Greater curvature of stomach, unspecified
0.000 0.907 0.093
E70-E90 Metabolic disorders
0.001 0.907 0.092
C16.5 Lesser curvature of stomach, unspecified
0.000 0.908 0.092
C26.9 Ill-defined sites within the digestive system
0.000 0.909 0.090
R31 Unspecified haematuria
0.091 0.909 0.000
C16.8 Overlapping lesion of stomach
0.000 0.913 0.087
C16.4 Pylorus
0.000 0.914 0.086
C16.1 Fundus of stomach
0.000 0.914 0.086
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.915 0.085
E11.3 With ophthalmic complications
0.000 0.915 0.085
E78.2 Mixed hyperlipidaemia
0.000 0.916 0.084
M45.X6 Ankylosing spondylitis (Lumbar region)
0.083 0.917 0.000
C16.3 Pyloric antrum
0.000 0.922 0.078
E83.8 Other disorders of mineral metabolism
0.057 0.923 0.020
E83.2 Disorders of zinc metabolism
0.057 0.923 0.020
E83.0 Disorders of copper metabolism
0.057 0.923 0.020
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.076 0.924 0.000
E83.9 Disorder of mineral metabolism, unspecified
0.056 0.924 0.020
E78.1 Pure hyperglyceridaemia
0.000 0.926 0.074
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.001 0.926 0.073
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.074 0.926 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.074 0.926 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.074 0.926 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.074 0.926 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.074 0.926 0.000
E84 Cystic fibrosis
0.001 0.928 0.072
E53.8 Deficiency of other specified B group vitamins
0.000 0.928 0.072
E78.6 Lipoprotein deficiency
0.000 0.930 0.070
M45.X2 Ankylosing spondylitis (Cervical region)
0.070 0.930 0.000
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.070 0.930 0.000
E88 Other metabolic disorders
0.000 0.932 0.068
E77 Disorders of glycoprotein metabolism
0.001 0.933 0.066
E76 Disorders of glycosaminoglycan metabolism
0.001 0.933 0.066
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.001 0.933 0.066
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.001 0.933 0.066
E83.3 Disorders of phosphorus metabolism
0.054 0.935 0.011
E78.3 Hyperchylomicronaemia
0.000 0.935 0.065
C22.0 Liver cell carcinoma
0.000 0.935 0.064
E85 Amyloidosis
0.001 0.936 0.064
E70 Disorders of aromatic amino-acid metabolism
0.001 0.936 0.063
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.936 0.064
E79 Disorders of purine and pyrimidine metabolism
0.001 0.936 0.063
E78.5 Hyperlipidaemia, unspecified
0.000 0.936 0.064
E73 Lactose intolerance
0.001 0.936 0.063
E72 Other disorders of amino-acid metabolism
0.001 0.938 0.061
C16.9 Stomach, unspecified
0.000 0.940 0.059
E74 Other disorders of carbohydrate metabolism
0.001 0.941 0.059
E88.9 Metabolic disorder, unspecified
0.000 0.942 0.058
E75.5 Other lipid storage disorders
0.001 0.942 0.057
E75.2 Other sphingolipidosis
0.001 0.943 0.056
E84.9 Cystic fibrosis, unspecified
0.001 0.944 0.056
C25.0 Head of pancreas
0.000 0.944 0.056
E84.0 Cystic fibrosis with pulmonary manifestations
0.001 0.946 0.053
E88.2 Lipomatosis, not elsewhere classified
0.000 0.946 0.053
E75.6 Lipid storage disorder, unspecified
0.001 0.947 0.053
E75.4 Neuronal ceroid lipofuscinosis
0.001 0.947 0.053
E75.3 Sphingolipidosis, unspecified
0.001 0.947 0.053
E75.1 Other gangliosidosis
0.001 0.947 0.053
E75.0 GM2 gangliosidosis
0.001 0.947 0.053
E84.8 Cystic fibrosis with other manifestations
0.001 0.948 0.052
E84.1 Cystic fibrosis with intestinal manifestations
0.001 0.948 0.052
E86 Volume depletion
0.000 0.949 0.051
E85.4 Organ-limited amyloidosis
0.000 0.949 0.051
E04 Other non-toxic goitre
0.001 0.950 0.049
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.951 0.049
E88.8 Other specified metabolic disorders
0.000 0.951 0.049
E71.3 Disorders of fatty-acid metabolism
0.001 0.952 0.048
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.001 0.952 0.048
E71.1 Other disorders of branched-chain amino-acid metabolism
0.001 0.952 0.048
E71.0 Maple-syrup-urine disease
0.001 0.952 0.048
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.001 0.952 0.048
E76.8 Other disorders of glucosaminoglycan metabolism
0.001 0.952 0.048
E76.3 Mucopolysaccharidosis, unspecified
0.001 0.952 0.048
E76.2 Other mucopolysaccharidoses
0.001 0.952 0.048
E76.1 Mucopolysaccharidosis, type II
0.001 0.952 0.048
E76.0 Mucopolysaccharidosis, type I
0.001 0.952 0.048
E77.9 Disorder of glycoprotein metabolism, unspecified
0.001 0.952 0.048
E77.8 Other disorders of glycoprotein metabolism
0.001 0.952 0.048
E77.1 Defects in glycoprotein degradation
0.001 0.952 0.048
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.001 0.952 0.048
E85.3 Secondary systemic amyloidosis
0.001 0.952 0.047
E78.4 Other hyperlipidaemia
0.000 0.952 0.047
E85.8 Other amyloidosis
0.001 0.953 0.047
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.954 0.046
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.954 0.046
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.954 0.046
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.001 0.954 0.046
E70.8 Other disorders of aromatic amino-acid metabolism
0.001 0.954 0.046
E70.2 Disorders of tyrosine metabolism
0.001 0.954 0.046
E70.1 Other hyperphenylalaninaemias
0.001 0.954 0.046
E70.0 Classical phenylketonuria
0.001 0.954 0.046
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.001 0.954 0.045
E79.8 Other disorders of purine and pyrimidine metabolism
0.001 0.954 0.045
E79.1 Lesch-Nyhan syndrome
0.001 0.954 0.045
E73.8 Other lactose intolerance
0.001 0.954 0.045
E73.1 Secondary lactase deficiency
0.001 0.954 0.045
E73.0 Congenital lactase deficiency
0.001 0.954 0.045
E88.3 Tumour lysis syndrome
0.000 0.954 0.045
E72.9 Disorder of amino-acid metabolism, unspecified
0.001 0.955 0.044
E72.8 Other specified disorders of amino-acid metabolism
0.001 0.955 0.044
E72.5 Disorders of glycine metabolism
0.001 0.955 0.044
E72.4 Disorders of ornithine metabolism
0.001 0.955 0.044
E72.3 Disorders of lysine and hydroxylysine metabolism
0.001 0.955 0.044
E72.2 Disorders of urea cycle metabolism
0.001 0.955 0.044
C18 Malignant neoplasm of colon
0.000 0.956 0.044
E72.0 Disorders of amino-acid transport
0.001 0.956 0.043
E78.8 Other disorders of lipoprotein metabolism
0.000 0.956 0.044
C18.1 Appendix
0.000 0.956 0.044
E80 Disorders of porphyrin and bilirubin metabolism
0.001 0.957 0.043
E70.3 Albinism
0.001 0.957 0.043
E74.9 Disorder of carbohydrate metabolism, unspecified
0.001 0.957 0.042
E74.8 Other specified disorders of carbohydrate metabolism
0.001 0.957 0.042
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.001 0.957 0.042
E74.2 Disorders of galactose metabolism
0.001 0.957 0.042
E74.1 Disorders of fructose metabolism
0.001 0.957 0.042
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.001 0.958 0.041
E73.9 Lactose intolerance, unspecified
0.001 0.958 0.042
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.001 0.959 0.040
E74.3 Other disorders of intestinal carbohydrate absorption
0.001 0.960 0.040
E74.0 Glycogen storage disease
0.001 0.961 0.038
E83.4 Disorders of magnesium metabolism
0.024 0.962 0.014
C18.9 Colon, unspecified
0.000 0.962 0.038
L40.5 Arthropathic psoriasis
0.000 0.963 0.037
E04.8 Other specified non-toxic goitre
0.001 0.964 0.035
E80.2 Other porphyria
0.000 0.964 0.035
C18.8 Overlapping lesion of colon
0.000 0.967 0.033
E85.9 Amyloidosis, unspecified
0.001 0.968 0.031
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.968 0.031
E20-E35 Disorders of other endocrine glands
0.000 0.968 0.032
E80.7 Disorder of bilirubin metabolism, unspecified
0.001 0.969 0.031
E80.5 Crigler-Najjar syndrome
0.001 0.969 0.031
E80.3 Defects of catalase and peroxydase
0.001 0.969 0.031
E80.0 Hereditary erythropoietic porphyria
0.001 0.969 0.031
L40 Psoriasis
0.000 0.969 0.031
E04.0 Non-toxic diffuse goitre
0.001 0.971 0.028
L40.0 Psoriasis vulgaris
0.000 0.971 0.029
E24 Cushing's syndrome
0.000 0.972 0.028
E80.1 Porphyria cutanea tarda
0.001 0.972 0.027
C18.4 Transverse colon
0.000 0.973 0.027
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.026 0.974 0.000
E80.6 Other disorders of bilirubin metabolism
0.001 0.974 0.025
M45-M49 Spondylopathies
0.025 0.975 0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.024 0.975 0.000
E20 Hypoparathyroidism
0.000 0.976 0.024
E25 Adrenogenital disorders
0.000 0.976 0.024
T39.0 Salicylates
0.024 0.976 0.000
C18.6 Descending colon
0.000 0.977 0.023
L40.9 Psoriasis, unspecified
0.000 0.977 0.023
E31 Polyglandular dysfunction
0.000 0.977 0.023
C18.3 Hepatic flexure
0.000 0.977 0.023
E24.0 Pituitary-dependent Cushing's disease
0.000 0.977 0.023
L40.3 Pustulosis palmaris et plantaris
0.000 0.977 0.023
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.977 0.023
E32 Diseases of thymus
0.000 0.977 0.023
E30 Disorders of puberty, not elsewhere classified
0.000 0.977 0.023
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.023 0.977 0.000
E24.9 Cushing's syndrome, unspecified
0.000 0.977 0.022
E83.5 Disorders of calcium metabolism
0.003 0.978 0.019
I83 Varicose veins of lower extremities
0.022 0.978 0.000
L40.1 Generalised pustular psoriasis
0.000 0.978 0.022
L40.4 Guttate psoriasis
0.000 0.978 0.022
L40.2 Acrodermatitis continua
0.000 0.978 0.022
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.022 0.978 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.022 0.978 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.022 0.978 0.000
E24.2 Drug-induced Cushing's syndrome
0.000 0.978 0.022
T50.9 Other and unspecified drugs, medicaments and biological substances
0.022 0.978 0.000
T39.1 4-Aminophenol derivatives
0.022 0.978 0.000
M47.12 Other spondylosis with myelopathy (Cervical region)
0.021 0.979 0.000
M20.5 Other deformities of toe(s) (acquired)
0.021 0.979 0.000
E24.8 Other Cushing's syndrome
0.000 0.979 0.021
K90-K93 Other diseases of the digestive system
0.000 0.979 0.021
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.980 0.020
E24.3 Ectopic ACTH syndrome
0.000 0.980 0.020
E24.1 Nelson's syndrome
0.000 0.980 0.020
M49 Spondylopathies in diseases classified elsewhere
0.020 0.980 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.020 0.980 0.000
E28 Ovarian dysfunction
0.000 0.980 0.020
E29 Testicular dysfunction
0.000 0.980 0.020
M47.1 Other spondylosis with myelopathy
0.020 0.980 0.000
T50.8 Diagnostic agents
0.020 0.980 0.000
T39.4 Antirheumatics, not elsewhere classified
0.019 0.981 0.000
T39.2 Pyrazolone derivatives
0.019 0.981 0.000
L40-L45 Papulosquamous disorders
0.000 0.981 0.019
E20.9 Hypoparathyroidism, unspecified
0.000 0.981 0.019
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified
0.018 0.982 0.000
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.982 0.018
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.018 0.982 0.000
T42.4 Benzodiazepines
0.018 0.982 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.018 0.982 0.000
M47 Spondylosis
0.018 0.982 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.018 0.982 0.000
T36 Poisoning by systemic antibiotics
0.018 0.982 0.000
E20.8 Other hypoparathyroidism
0.000 0.982 0.017
E20.1 Pseudohypoparathyroidism
0.000 0.982 0.017
E20.0 Idiopathic hypoparathyroidism
0.000 0.982 0.017
E66 Obesity
0.000 0.982 0.017
T50.4 Drugs affecting uric acid metabolism
0.017 0.982 0.000
E31.0 Autoimmune polyglandular failure
0.000 0.983 0.017
E25.9 Adrenogenital disorder, unspecified
0.000 0.983 0.017
E25.8 Other adrenogenital disorders
0.000 0.983 0.017
E31.9 Polyglandular dysfunction, unspecified
0.000 0.983 0.017
E31.8 Other polyglandular dysfunction
0.000 0.983 0.017
E31.1 Polyglandular hyperfunction
0.000 0.983 0.017
L43 Lichen planus
0.000 0.983 0.017
T42.0 Hydantoin derivatives
0.017 0.983 0.000
E22 Hyperfunction of pituitary gland
0.000 0.983 0.017
E30.9 Disorder of puberty, unspecified
0.000 0.983 0.017
E30.8 Other disorders of puberty
0.000 0.983 0.017
E30.1 Precocious puberty
0.000 0.983 0.017
E30.0 Delayed puberty
0.000 0.983 0.017
E32.9 Disease of thymus, unspecified
0.000 0.983 0.017
E32.8 Other diseases of thymus
0.000 0.983 0.017
E32.1 Abscess of thymus
0.000 0.983 0.017
E32.0 Persistent hyperplasia of thymus
0.000 0.983 0.017
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.983 0.017
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.983 0.017
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.983 0.017
M49.5 Collapsed vertebra in diseases classified elsewhere
0.017 0.983 0.000
L43.9 Lichen planus, unspecified
0.000 0.983 0.017
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.016 0.984 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.000 0.984 0.016
T50.7 Analeptics and opioid receptor antagonists
0.016 0.984 0.000
T50.5 Appetite depressants
0.016 0.984 0.000
T50.3 Electrolytic, caloric and water-balance agents
0.016 0.984 0.000
T50.0 Mineralocorticoids and their antagonists
0.016 0.984 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.016 0.984 0.000
M47.16 Other spondylosis with myelopathy (Lumbar region)
0.016 0.984 0.000
E87.7 Fluid overload
0.000 0.984 0.016
H40.2 Primary angle-closure glaucoma
0.016 0.984 0.000
E34 Other endocrine disorders
0.000 0.984 0.015
C18.7 Sigmoid colon
0.000 0.985 0.015
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.015 0.985 0.000
T37.8 Other specified systemic anti-infectives and antiparasitics
0.015 0.985 0.000
T50.1 Loop [high-ceiling] diuretics
0.015 0.985 0.000
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.985 0.015
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics
0.015 0.985 0.000
L40.8 Other psoriasis
0.000 0.985 0.015
E26 Hyperaldosteronism
0.000 0.985 0.014
M47.14 Other spondylosis with myelopathy (Thoracic region)
0.015 0.985 0.000
M49.8 Spondylopathy in other diseases classified elsewhere
0.015 0.985 0.000
M49.4 Neuropathic spondylopathy
0.015 0.985 0.000
M49.3 Spondylopathy in other infectious and parasitic diseases classified elsewhere
0.015 0.985 0.000
M49.2 Enterobacterial spondylitis
0.015 0.985 0.000
M49.1 Brucella spondylitis
0.015 0.985 0.000
M49.0 Tuberculosis of spine
0.015 0.985 0.000
T42.5 Mixed antiepileptics, not elsewhere classified
0.015 0.985 0.000
T42.2 Succinimides and oxazolidinediones
0.015 0.985 0.000
E29.9 Testicular dysfunction, unspecified
0.000 0.985 0.015
T40.5 Cocaine
0.015 0.985 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.015 0.985 0.000
M49.54 Collapsed vertebra in diseases classified elsewhere (Thoracic region)
0.014 0.986 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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