TreeWAS – Variant ID: rs142816172

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
N84.0 Polyp of corpus uteri	0.053	0.947	0.000
M54.56 Low back pain (Lumbar region)	0.000	0.972	0.028
M54.59 Low back pain (Site unspecified)	0.000	0.973	0.027
M54.5 Low back pain	0.000	0.973	0.027
M54.58 Low back pain (Sacral and sacrococcygeal region)	0.000	0.977	0.023
S82.80 Fractures of other parts of lower leg (closed)	0.022	0.978	0.000
M54.57 Low back pain (Lumbosacral region)	0.000	0.981	0.019
M54.55 Low back pain (Thoracolumbar region)	0.000	0.981	0.019
M54.54 Low back pain-Thoracic	0.000	0.981	0.019
M54.53 Low back pain-Cervicothoracic	0.000	0.981	0.019
M54.52 Low back pain-Cervical	0.000	0.981	0.019
M54.51 Low back pain-Occipit-atl-axl	0.000	0.981	0.019
N84 Polyp of female genital tract	0.018	0.982	0.000
M54.50 Low back pain (Multiple sites in spine)	0.000	0.982	0.018
S82.8 Fractures of other parts of lower leg	0.017	0.983	0.000
N84.2 Polyp of vagina	0.016	0.984	0.000
N84.9 Polyp of female genital tract, unspecified	0.013	0.987	0.000
N84.8 Polyp of other parts of female genital tract	0.013	0.987	0.000
N84.3 Polyp of vulva	0.013	0.987	0.000
S82.81 Fractures of other parts of lower leg (open)	0.013	0.987	0.000
S82.86 Maisonneuve's fracture	0.012	0.988	0.000
S82 Fracture of lower leg, including ankle	0.012	0.988	0.000
S82.0 Fracture of patella	0.011	0.989	0.000
S82.01 Fracture of patella (open)	0.010	0.990	0.000
S82.3 Fracture of lower end of tibia	0.010	0.990	0.000
S82.00 Fracture of patella (closed)	0.009	0.991	0.000
S82.9 Fracture of lower leg, part unspecified	0.009	0.991	0.000
S82.7 Multiple fractures of lower leg	0.009	0.991	0.000
S82.2 Fracture of shaft of tibia	0.009	0.991	0.000
S82.30 Fracture of lower end of tibia (closed)	0.008	0.992	0.000
S82.1 Fracture of upper end of tibia	0.008	0.992	0.000
S82.4 Fracture of fibula alone	0.008	0.992	0.000
S82.5 Fracture of medial malleolus	0.008	0.992	0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.008	0.992	0.000
S82.31 Fracture of lower end of tibia (open)	0.007	0.993	0.000
S82.6 Fracture of lateral malleolus	0.007	0.993	0.000
K83.1 Obstruction of bile duct	0.007	0.993	0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs	0.007	0.993	0.000
Y44 Agents primarily affecting blood constituents	0.007	0.993	0.000
N84.1 Polyp of cervix uteri	0.007	0.993	0.000
Y52 Agents primarily affecting the cardiovascular system	0.007	0.993	0.000
S82.71 Multiple fractures of lower leg (open)	0.006	0.993	0.000
S82.70 Multiple fractures of lower leg (closed)	0.006	0.993	0.000
S82.91 Fracture of lower leg, part unspecified (open)	0.006	0.993	0.000
S82.90 Fracture of lower leg, part unspecified (closed)	0.006	0.993	0.000
S82.21 Fracture of shaft of tibia (open)	0.006	0.993	0.000
Y43 Primarily systemic agents	0.006	0.993	0.000
Y53 Agents primarily affecting the gastro-intestinal system	0.006	0.994	0.000
S82.20 Fracture of shaft of tibia (closed)	0.006	0.994	0.000
Y44.2 Anticoagulants	0.006	0.994	0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism	0.006	0.994	0.000
Y51 Drugs primarily affecting the autonomic nervous system	0.006	0.994	0.000
S82.11 Fracture of upper end of tibia (open)	0.006	0.994	0.000
K83.0 Cholangitis	0.006	0.994	0.000
Y45.0 Opioids and related analgesics	0.006	0.994	0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs	0.006	0.994	0.000
Y48 Anaesthetics and therapeutic gases	0.006	0.994	0.000
Y52.5 Other antihypertensive drugs, not elsewhere classified	0.006	0.994	0.000
S80-S89 Injuries to the knee and lower leg	0.006	0.994	0.000
S82.41 Fracture of fibula alone (open)	0.006	0.994	0.000
S82.51 Fracture of medial malleolus (open)	0.006	0.994	0.000
Y40 Systemic antibiotics	0.006	0.994	0.000
Y59 Other and unspecified vaccines and biological substances	0.006	0.994	0.000
Y58 Bacterial vaccines	0.006	0.994	0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system	0.006	0.994	0.000
Y50 Central nervous system stimulants, not elsewhere classified	0.006	0.994	0.000
Y49 Psychotropic drugs, not elsewhere classified	0.006	0.994	0.000
Y47 Sedatives, hypnotics and antianxiety drugs	0.006	0.994	0.000
Y46 Antiepileptics and anti-Parkinsonism drugs	0.006	0.994	0.000
Y41 Other systemic anti-infectives and antiparasitics	0.006	0.994	0.000
Y53.1 Other antacids and anti-gastric-secretion drugs	0.006	0.994	0.000
K83 Other diseases of biliary tract	0.006	0.994	0.000
M54 Dorsalgia	0.000	0.994	0.006
Y45.3 Other nonsteroidal anti-inflammatory drugs [NSAID]	0.006	0.994	0.000
S82.10 Fracture of upper end of tibia (closed)	0.005	0.994	0.000
Y57 Other and unspecified drugs and medicaments	0.006	0.994	0.000
S80 Superficial injury of lower leg	0.006	0.994	0.000
Y54.3 Benzothiadiazine derivatives	0.005	0.994	0.000
Y51.7 Beta-Adrenoreceptor antagonists, not elsewhere classified	0.005	0.995	0.000
Y43.1 Antineoplastic antimetabolites	0.005	0.995	0.000
Y43.3 Other antineoplastic drugs	0.005	0.995	0.000
S82.40 Fracture of fibula alone (closed)	0.005	0.995	0.000
S82.61 Fracture of lateral malleolus (open)	0.005	0.995	0.000
S82.50 Fracture of medial malleolus (closed)	0.005	0.995	0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.005	0.995	0.000
Y44.9 Other and unspecified agents affecting blood constituents	0.005	0.995	0.000
Y44.7 Plasma substitutes	0.005	0.995	0.000
Y44.6 Natural blood and blood products	0.005	0.995	0.000
Y44.5 Thrombolytic drugs	0.005	0.995	0.000
Y44.4 Antithrombotic drugs [platelet-aggregation inhibitors]	0.005	0.995	0.000
Y44.3 Anticoagulant antagonists, vitamin K and other coagulants	0.005	0.995	0.000
Y44.1 Vitamin B12, folic acid and other anti-megaloblastic-anaemia preparations	0.005	0.995	0.000
Y44.0 Iron preparations and other anti-hypochromic-anaemia preparations	0.005	0.995	0.000
Y45.9 Analgesic, antipyretic and anti-inflammatory drug, unspecified	0.005	0.995	0.000
Y45.8 Other analgesics and antipyretics	0.005	0.995	0.000
Y45.5 4-Aminophenol derivatives	0.005	0.995	0.000
Y45.4 Antirheumatics	0.005	0.995	0.000
Y45.2 Propionic acid derivatives	0.005	0.995	0.000
S80.8 Other superficial injuries of lower leg	0.005	0.995	0.000
Y56.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified	0.005	0.995	0.000
Y48.3 Local anaesthetics	0.005	0.995	0.000
Y45.1 Salicylates	0.005	0.995	0.000
Y52.9 Other and unspecified agents primarily affecting the cardiovascular system	0.005	0.995	0.000
Y52.8 Antivaricose drugs, including sclerosing agents	0.005	0.995	0.000
Y52.7 Peripheral vasodilators	0.005	0.995	0.000
Y52.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.005	0.995	0.000
Y52.4 Angiotensin-converting-enzyme inhibitors	0.005	0.995	0.000
Y52.2 Other antidysrhythmic drugs, not elsewhere classified	0.005	0.995	0.000
Y52.1 Calcium-channel blockers	0.005	0.995	0.000
Y52.0 Cardiac-stimulant glycosides and drugs of similar action	0.005	0.995	0.000
Y43.9 Primarily systemic agent, unspecified	0.005	0.995	0.000
Y43.8 Other primarily systemic agents, not elsewhere classified	0.005	0.995	0.000
Y43.6 Enzymes, not elsewhere classified	0.005	0.995	0.000
Y43.5 Acidifying and alkalising agents	0.005	0.995	0.000
Y43.4 Immunosuppressive agents	0.005	0.995	0.000
Y43.2 Antineoplastic natural products	0.005	0.995	0.000
Y43.0 Antiallergic and antiemetic drugs	0.005	0.995	0.000
Y53.9 Agent primarily affecting the gastro-intestinal system, unspecified	0.005	0.995	0.000
Y53.8 Other agents primarily affecting the gastro-intestinal system	0.005	0.995	0.000
Y53.7 Emetics	0.005	0.995	0.000
Y53.6 Antidiarrhoeal drugs	0.005	0.995	0.000
Y53.5 Digestants	0.005	0.995	0.000
Y53.4 Other laxatives	0.005	0.995	0.000
Y53.3 Saline and osmotic laxatives	0.005	0.995	0.000
Y53.2 Stimulant laxatives	0.005	0.995	0.000
Y53.0 Histamine H2-receptor antagonists	0.005	0.995	0.000
M54.3 Sciatica	0.000	0.995	0.005
Y54.9 Mineral salts, not elsewhere classified	0.005	0.995	0.000
Y54.8 Agents affecting uric acid metabolism	0.005	0.995	0.000
Y54.7 Agents affecting calcification	0.005	0.995	0.000
Y54.6 Electrolytic, caloric and water-balance agents	0.005	0.995	0.000
Y54.5 Other diuretics	0.005	0.995	0.000
Y54.4 Loop [high-ceiling] diuretics	0.005	0.995	0.000
Y54.2 Carbonic-anhydrase inhibitors	0.005	0.995	0.000
Y54.1 Mineralocorticoid antagonists [aldosterone antagonists]	0.005	0.995	0.000
Y54.0 Mineralocorticoids	0.005	0.995	0.000
Y51.9 Other and unspecified drugs primarily affecting the autonomic nervous system	0.005	0.995	0.000
Y51.8 Centrally acting and adrenergic-neuron-blocking agents, not elsewhere classified	0.005	0.995	0.000
Y51.6 @-Adrenoreceptor antagonists, not elsewhere classified	0.005	0.995	0.000
Y51.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified	0.005	0.995	0.000
Y51.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified	0.005	0.995	0.000
Y51.3 Other parasympatholytics [anticholinergics and antimuscarinics] and spasmolytics, not elsewhere classified	0.005	0.995	0.000
Y51.2 Ganglionic blocking drugs, not elsewhere classified	0.005	0.995	0.000
Y51.1 Other parasympathomimetics [cholinergics]	0.005	0.995	0.000
Y51.0 Anticholinesterase agents	0.005	0.995	0.000
Y52.3 Coronary vasodilators, not elsewhere classified	0.005	0.995	0.000
S80.1 Contusion of other and unspecified parts of lower leg	0.005	0.995	0.000
Y56.9 Topical agent, unspecified	0.004	0.995	0.000
Y56.8 Other topical agents	0.004	0.995	0.000
Y56.7 Dental drugs, topically applied	0.004	0.995	0.000
Y56.6 Otorhinolaryngological drugs and preparations	0.004	0.995	0.000
Y56.5 Ophthalmological drugs and preparations	0.004	0.995	0.000
Y56.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations	0.004	0.995	0.000
Y56.3 Emollients, demulcents and protectants	0.004	0.995	0.000
Y56.2 Local astringents and local detergents	0.004	0.995	0.000
Y56.1 Antipruritics	0.004	0.995	0.000
Y48.5 Therapeutic gases	0.004	0.995	0.000
Y48.4 Anaesthetic, unspecified	0.004	0.995	0.000
Y48.2 Other and unspecified general anaesthetics	0.004	0.995	0.000
Y48.1 Parenteral anaesthetics	0.004	0.995	0.000
Y48.0 Inhaled anaesthetics	0.004	0.995	0.000
S88 Traumatic amputation of lower leg	0.004	0.995	0.000
S87 Crushing injury of lower leg	0.004	0.995	0.000
S86 Injury of muscle and tendon at lower leg level	0.004	0.995	0.000
S85 Injury of blood vessels at lower leg level	0.004	0.995	0.000
S84 Injury of nerves at lower leg level	0.004	0.995	0.000
M54.36 Sciatica (Lumbar region)	0.000	0.995	0.005
Y57.5 X-ray contrast media	0.004	0.995	0.000
Y40.9 Systemic antibiotic, unspecified	0.004	0.995	0.000
Y40.8 Other systemic antibiotics	0.004	0.996	0.000
Y40.7 Antifungal antibiotics, systemically used	0.004	0.996	0.000
Y40.6 Rifamycins	0.004	0.996	0.000
Y40.5 Aminoglycosides	0.004	0.996	0.000
Y40.4 Tetracyclines	0.004	0.996	0.000
Y40.3 Macrolides	0.004	0.996	0.000
Y40.2 Chloramphenicol group	0.004	0.996	0.000
Y40.1 Cefalosporins and other -lactam antibiotics	0.004	0.996	0.000
Y41.9 Systemic anti-infective and antiparasitic, unspecified	0.004	0.996	0.000
Y41.8 Other specified systemic anti-infectives and antiparasitics	0.004	0.996	0.000
Y41.5 Antiviral drugs	0.004	0.996	0.000
Y41.4 Anthelminthics	0.004	0.996	0.000
Y41.3 Other antiprotozoal drugs	0.004	0.996	0.000
Y41.2 Antimalarials and drugs acting on other blood protozoa	0.004	0.996	0.000
Y41.1 Antimycobacterial drugs	0.004	0.996	0.000
Y41.0 Sulphonamides	0.004	0.996	0.000
Y46.8 Antispasticity drugs	0.004	0.996	0.000
Y46.7 Anti-Parkinsonism drugs	0.004	0.996	0.000
Y46.6 Other and unspecified antiepileptics	0.004	0.996	0.000
Y46.5 Valproic acid	0.004	0.996	0.000
Y46.4 Iminostilbenes	0.004	0.996	0.000
Y46.3 Deoxybarbiturates	0.004	0.996	0.000
Y46.2 Hydantoin derivatives	0.004	0.996	0.000
Y46.1 Oxazolidinediones	0.004	0.996	0.000
Y46.0 Succinimides	0.004	0.996	0.000
Y47.9 Sedative, hypnotic and antianxiety drug, unspecified	0.004	0.996	0.000
Y47.8 Other sedatives, hypnotics and antianxiety drugs	0.004	0.996	0.000
Y47.5 Mixed sedatives and hypnotics, not elsewhere classified	0.004	0.996	0.000
Y47.4 Bromine compounds	0.004	0.996	0.000
Y47.3 Paraldehyde	0.004	0.996	0.000
Y47.2 Chloral derivatives	0.004	0.996	0.000
Y47.1 Benzodiazepines	0.004	0.996	0.000
Y47.0 Barbiturates, not elsewhere classified	0.004	0.996	0.000
Y49.9 Psychotropic drug, unspecified	0.004	0.996	0.000
Y49.8 Other psychotropic drugs, not elsewhere classified	0.004	0.996	0.000
Y49.7 Psychostimulants with abuse potential	0.004	0.996	0.000
Y49.6 Psychodysleptics [hallucinogens]	0.004	0.996	0.000
Y49.5 Other antipsychotics and neuroleptics	0.004	0.996	0.000
Y49.4 Butyrophenone and thioxanthene neuroleptics	0.004	0.996	0.000
Y49.3 Phenothiazine antipsychotics and neuroleptics	0.004	0.996	0.000
Y49.2 Other and unspecified antidepressants	0.004	0.996	0.000
Y49.1 Monoamine-oxidase-inhibitor antidepressants	0.004	0.996	0.000
Y49.0 Tricyclic and tetracyclic antidepressants	0.004	0.996	0.000
Y50.9 Central nervous system stimulant, unspecified	0.004	0.996	0.000
Y50.8 Other central nervous system stimulants	0.004	0.996	0.000
Y50.2 Methylxanthines, not elsewhere classified	0.004	0.996	0.000
Y50.1 Opioid receptor antagonists	0.004	0.996	0.000
Y50.0 Analeptics	0.004	0.996	0.000
Y55.7 Other and unspecified agents primarily acting on the respiratory system	0.004	0.996	0.000
Y55.6 Antiasthmatics, not elsewhere classified	0.004	0.996	0.000
Y55.5 Anticommon cold drugs	0.004	0.996	0.000
Y55.4 Expectorants	0.004	0.996	0.000
Y55.3 Antitussives	0.004	0.996	0.000
Y55.2 Other and unspecified agents primarily acting on muscles	0.004	0.996	0.000
Y55.1 Skeletal muscle relaxants [neuromuscular blocking agents]	0.004	0.996	0.000
Y55.0 Oxytocic drugs	0.004	0.996	0.000
Y58.9 Other and unspecified bacterial vaccines	0.004	0.996	0.000
Y58.8 Mixed bacterial vaccines, except combinations with a pertussis component	0.004	0.996	0.000
Y58.6 Pertussis vaccine, including combinations with a pertussis component	0.004	0.996	0.000
Y58.5 Diphtheria vaccine	0.004	0.996	0.000
Y58.4 Tetanus vaccine	0.004	0.996	0.000
Y58.3 Plague vaccine	0.004	0.996	0.000
Y58.2 Cholera vaccine	0.004	0.996	0.000
Y58.1 Typhoid and paratyphoid vaccine	0.004	0.996	0.000
Y58.0 BCG vaccine	0.004	0.996	0.000
Y59.9 Vaccine or biological substance, unspecified	0.004	0.996	0.000
Y59.8 Other specified vaccines and biological substances	0.004	0.996	0.000
Y59.3 Immunoglobulin	0.004	0.996	0.000
Y59.2 Protozoal vaccines	0.004	0.996	0.000
Y59.1 Rickettsial vaccines	0.004	0.996	0.000
Y59.0 Viral vaccines	0.004	0.996	0.000
K83.9 Disease of biliary tract, unspecified	0.004	0.996	0.000
K83.5 Biliary cyst	0.004	0.996	0.000
K83.4 Spasm of sphincter of Oddi	0.004	0.996	0.000
K83.3 Fistula of bile duct	0.004	0.996	0.000
K83.2 Perforation of bile duct	0.004	0.996	0.000
M54.8 Other dorsalgia	0.000	0.996	0.004
M54.0 Panniculitis affecting regions of neck and back	0.000	0.996	0.004
M54.6 Pain in thoracic spine	0.000	0.996	0.004
Y42.5 Other oestrogens and progestogens	0.004	0.996	0.000
Y57.8 Other drugs and medicaments	0.004	0.996	0.000
Y57.7 Vitamins, not elsewhere classified	0.004	0.996	0.000
Y57.6 Other diagnostic agents	0.004	0.996	0.000
Y57.4 Pharmaceutical excipients	0.004	0.996	0.000
Y57.3 Alcohol deterrents	0.004	0.996	0.000
Y57.2 Antidotes and chelating agents, not elsewhere classified	0.004	0.996	0.000
Y57.1 Lipotropic drugs	0.004	0.996	0.000
Y57.0 Appetite depressants [anorectics]	0.004	0.996	0.000
S80.7 Multiple superficial injuries of lower leg	0.004	0.996	0.000
S81 Open wound of lower leg	0.004	0.996	0.000
S80.0 Contusion of knee	0.004	0.996	0.000
Y40.0 Penicillins	0.004	0.996	0.000
S89 Other and unspecified injuries of lower leg	0.004	0.996	0.000
S80.9 Superficial injury of lower leg, unspecified	0.004	0.996	0.000
Y42.9 Other and unspecified hormone antagonists	0.004	0.996	0.000
Y42.6 Antigonadotrophins, antioestrogens, antiandrogens, not elsewhere classified	0.004	0.996	0.000
Y42.4 Oral contraceptives	0.004	0.996	0.000
Y42.3 Insulin and oral hypoglycaemic [antidiabetic] drugs	0.004	0.996	0.000
Y42.2 Antithyroid drugs	0.004	0.996	0.000
Y42.1 Thyroid hormones and substitutes	0.004	0.996	0.000
Y42.0 Glucocorticoids and synthetic analogs	0.004	0.996	0.000
M54.1 Radiculopathy	0.000	0.996	0.004
Y42.8 Other and unspecified hormones and their synthetic substitutes	0.004	0.996	0.000
Y57.9 Drug or medicament, unspecified	0.004	0.996	0.000
R19.8 Other specified symptoms and signs involving the digestive system and abdomen	0.000	0.996	0.004
M54.38 Sciatica (Sacral and sacrococcygeal region)	0.000	0.996	0.004
M54.37 Sciatica (Lumbosacral region)	0.000	0.996	0.004
M54.35 Sciatica (Thoracolumbar region)	0.000	0.996	0.004
M54.34 Sciatica-Thoracic	0.000	0.996	0.004
M54.33 Sciatica-Cervicothoracic	0.000	0.996	0.004
M54.32 Sciatica-Cervical	0.000	0.996	0.004
M54.31 Sciatica-Occipit-atl-axl	0.000	0.996	0.004
M54.30 Sciatica (Multiple sites in spine)	0.000	0.996	0.004
S81.9 Open wound of lower leg, part unspecified	0.004	0.996	0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee	0.004	0.996	0.000
M54.4 Lumbago with sciatica	0.000	0.996	0.003
S82.60 Fracture of lateral malleolus (closed)	0.003	0.996	0.000
S84.9 Injury of unspecified nerve at lower leg level	0.003	0.996	0.000
S84.8 Injury of other nerves at lower leg level	0.003	0.996	0.000
S84.7 Injury of multiple nerves at lower leg level	0.003	0.996	0.000
S84.2 Injury of cutaneous sensory nerve at lower leg level	0.003	0.996	0.000
S84.1 Injury of peroneal nerve at lower leg level	0.003	0.996	0.000
S84.0 Injury of tibial nerve at lower leg level	0.003	0.996	0.000
S85.9 Injury of unspecified blood vessel at lower leg level	0.003	0.996	0.000
S85.8 Injury of other blood vessels at lower leg level	0.003	0.996	0.000
S85.7 Injury of multiple blood vessels at lower leg level	0.003	0.996	0.000
S85.5 Injury of popliteal vein	0.003	0.996	0.000
S85.4 Injury of lesser saphenous vein at lower leg level	0.003	0.996	0.000
S85.3 Injury of greater saphenous vein at lower leg level	0.003	0.996	0.000
S85.2 Injury of peroneal artery	0.003	0.996	0.000
S85.1 Injury of (anterior)(posterior) tibial artery	0.003	0.996	0.000
S85.0 Injury of popliteal artery	0.003	0.996	0.000
S86.0 Injury of Achilles tendon	0.003	0.996	0.000
S86.9 Injury of unspecified muscle and tendon at lower leg level	0.003	0.996	0.000
S86.8 Injury of other muscles and tendons at lower leg level	0.003	0.996	0.000
S86.7 Injury of multiple muscles and tendons at lower leg level	0.003	0.996	0.000
S86.3 Injury of muscle(s) and tendon(s) of peroneal muscle group at lower leg level	0.003	0.996	0.000
S86.2 Injury of muscle(s) and tendon(s) of anterior muscle group at lower leg level	0.003	0.996	0.000
S86.1 Injury of other muscle(s) and tendon(s) of posterior muscle group at lower leg level	0.003	0.996	0.000
S87.8 Crushing injury of other and unspecified parts of lower leg	0.003	0.996	0.000
S87.0 Crushing injury of knee	0.003	0.996	0.000
S88.9 Traumatic amputation of lower leg, level unspecified	0.003	0.996	0.000
S88.1 Traumatic amputation at level between knee and ankle	0.003	0.996	0.000
S88.0 Traumatic amputation at knee level	0.003	0.996	0.000
K83.8 Other specified diseases of biliary tract	0.004	0.996	0.000
M54.2 Cervicalgia	0.000	0.996	0.003
M54.09 Panniculitis affecting regions of neck and back (Site unspecified)	0.000	0.997	0.003
M54.08 Panniculitis affecting regions of neck and back (Sacral and sacrococcygeal region)	0.000	0.997	0.003
M54.07 Panniculitis affecting regions of neck and back (Lumbosacral region)	0.000	0.997	0.003
M54.06 Panniculitis affecting regions of neck and back (Lumbar region)	0.000	0.997	0.003
M54.05 Panniculitis affecting regions of neck and back (Thoracolumbar region)	0.000	0.997	0.003
M54.04 Panniculitis affecting regions of neck and back (Thoracic region)	0.000	0.997	0.003
M54.03 Panniculitis affecting regions of neck and back (Cervicothoracic region)	0.000	0.997	0.003
M54.02 Panniculitis affecting regions of neck and back (Cervical region)	0.000	0.997	0.003
M54.01 Panniculitis affecting regions of neck and back (Occipito-atlanto-axial region)	0.000	0.997	0.003
M54.00 Panniculitis affecting regions of neck and back (Multiple sites in spine)	0.000	0.997	0.003
M54.89 Other dorsalgia (Site unspecified)	0.000	0.997	0.003
M54.88 Other dorsalgia (Sacral and sacrococcygeal region)	0.000	0.997	0.003
M54.87 Other dorsalgia (Lumbosacral region)	0.000	0.997	0.003
M54.86 Other dorsalgia (Lumbar region)	0.000	0.997	0.003
M54.85 Other dorsalgia (Thoracolumbar region)	0.000	0.997	0.003
M54.84 Other dorsalgia (Thoracic region)	0.000	0.997	0.003
M54.83 Other dorsalgia (Cervicothoracic region)	0.000	0.997	0.003
M54.82 Other dorsalgia (Cervical region)	0.000	0.997	0.003
M54.81 Other dorsalgia (Occipito-atlanto-axial region)	0.000	0.997	0.003
M54.80 Other dorsalgia (Multiple sites in spine)	0.000	0.997	0.003
M54.69 Pain in thoracic spine-Site unspe	0.000	0.997	0.003
M54.68 Pain in thoracic spine-Sacral/sacrococ	0.000	0.997	0.003
M54.67 Pain in thoracic spine-Lumbosacral	0.000	0.997	0.003
M54.66 Pain in thoracic spine-Lumbar	0.000	0.997	0.003
M54.65 Pain in thoracic spine (Thoracolumbar region)	0.000	0.997	0.003
M54.63 Pain in thoracic spine (Cervicothoracic region)	0.000	0.997	0.003
M54.62 Pain in thoracic spine-Cervical	0.000	0.997	0.003
M54.61 Pain in thoracic spine-Occipit-atl-axl	0.000	0.997	0.003
M54.60 Pain in thoracic spine (Multiple sites in spine)	0.000	0.997	0.003
M54.39 Sciatica (Site unspecified)	0.000	0.997	0.003
M54.64 Pain in thoracic spine (Thoracic region)	0.000	0.997	0.003
S81.7 Multiple open wounds of lower leg	0.003	0.997	0.000
Y42.7 Androgens and anabolic congeners	0.003	0.997	0.000
S89.8 Other specified injuries of lower leg	0.003	0.997	0.000
S89.7 Multiple injuries of lower leg	0.003	0.997	0.000
S89.1 Other specified injuries of lower leg	0.003	0.997	0.000
S89.0 Multiple injuries of lower leg	0.003	0.997	0.000
G55.1 Nerve root and plexus compressions in intervertebral disk disorders	0.003	0.997	0.000
M54.19 Radiculopathy (Site unspecified)	0.000	0.997	0.003
M54.18 Radiculopathy (Sacral and sacrococcygeal region)	0.000	0.997	0.003
M54.16 Radiculopathy (Lumbar region)	0.000	0.997	0.003
M54.15 Radiculopathy (Thoracolumbar region)	0.000	0.997	0.003
M54.14 Radiculopathy (Thoracic region)	0.000	0.997	0.003
M54.13 Radiculopathy (Cervicothoracic region)	0.000	0.997	0.003
M54.11 Radiculopathy (Occipito-atlanto-axial region)	0.000	0.997	0.003
M54.10 Radiculopathy (Multiple sites in spine)	0.000	0.997	0.003
K74.6 Other and unspecified cirrhosis of liver	0.003	0.997	0.000
S09.9 Unspecified injury of head	0.003	0.997	0.000
S81.0 Open wound of knee	0.003	0.997	0.000
M54.17 Radiculopathy (Lumbosacral region)	0.000	0.997	0.003
M54.48 Lumbago with sciatica (Sacral and sacrococcygeal region)	0.000	0.997	0.003
M54.47 Lumbago with sciatica (Lumbosacral region)	0.000	0.997	0.003
M54.45 Lumbago with sciatica (Thoracolumbar region)	0.000	0.997	0.003
M54.44 Lumbago with sciatica-Thoracic	0.000	0.997	0.003
M54.43 Lumbago with sciatica-Cervicothoracic	0.000	0.997	0.003
M54.42 Lumbago with sciatica-Cervical	0.000	0.997	0.003
M54.41 Lumbago with sciatica-Occipit-atl-axl	0.000	0.997	0.003
M54.40 Lumbago with sciatica (Multiple sites in spine)	0.000	0.997	0.003
S83.7 Injury to multiple structures of knee	0.003	0.997	0.000
S83.6 Sprain and strain of other and unspecified parts of knee	0.003	0.997	0.000
S83.4 Sprain and strain involving (fibular)(tibial) collateral ligamnent of knee	0.003	0.997	0.000
S83.3 Tear of articular cartilage of knee, current	0.003	0.997	0.000
S83.1 Dislocation of knee	0.003	0.997	0.000
S83.0 Dislocation of patella	0.003	0.997	0.000
M54.12 Radiculopathy (Cervical region)	0.000	0.997	0.003
V23.4 Driver injured in traffic accident	0.003	0.997	0.000
S86.00 Unspecified injury of Achilles tendon	0.003	0.997	0.000
M54.9 Dorsalgia, unspecified	0.000	0.997	0.003
M54.28 Cervicalgia-Sacral/sacrococ	0.000	0.997	0.003
M54.27 Cervicalgia-Lumbosacral	0.000	0.997	0.003
M54.26 Cervicalgia-Lumbar	0.000	0.997	0.003
M54.25 Cervicalgia-Thoracolumbar	0.000	0.997	0.003
M54.24 Cervicalgia-Thoracic	0.000	0.997	0.003
M54.23 Cervicalgia (Cervicothoracic region)	0.000	0.997	0.003
M54.21 Cervicalgia (Occipito-atlanto-axial region)	0.000	0.997	0.003
M54.20 Cervicalgia-Mult site	0.000	0.997	0.003
S09 Other and unspecified injuries of head	0.003	0.997	0.000
S89.9 Unspecified injury of lower leg	0.002	0.997	0.000
E10.9 Without complications	0.000	0.997	0.003
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.003	0.997	0.000
M54.46 Lumbago with sciatica (Lumbar region)	0.000	0.997	0.002
V23 Motorcycle rider injured in collision with car, pick-up truck or van	0.003	0.997	0.000
M54.29 Cervicalgia-Site unspe	0.000	0.997	0.002
M54.49 Lumbago with sciatica (Site unspecified)	0.000	0.997	0.002
S81.8 Open wound of other parts of lower leg	0.002	0.997	0.000
S83.2 Tear of meniscus, current	0.002	0.997	0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.002	0.997	0.000
T15-T19 Effects of foreign body entering through natural orifice	0.002	0.997	0.000
S00-S09 Injuries to the head	0.003	0.997	0.000
K80.1 Calculus of gallbladder with other cholecystitis	0.003	0.997	0.000
S70-S79 Injuries to the hip and thigh	0.003	0.997	0.000
T31.0 Burns involving less than 10% of body surface	0.002	0.997	0.000
T31 Burns classified according to extent of body surface involved	0.002	0.997	0.000
E14.3 With ophthalmic complications	0.000	0.997	0.002
V20-V29 Motorcycle rider injured in transport accident	0.002	0.997	0.000
F40.2 Specific (isolated) phobias	0.000	0.998	0.002
S83.5 Sprain and strain involving (anterior)(posterior) cruciate ligament of knee	0.002	0.998	0.000
T18 Foreign body in alimentary tract	0.002	0.998	0.000
T18.1 Foreign body in oesophagus	0.002	0.998	0.000
M54.96 Dorsalgia, unspecified (Lumbar region)	0.000	0.998	0.002
S05 Injury of eye and orbit	0.002	0.998	0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.002	0.998	0.000
H65.3 Chronic mucoid otitis media	0.002	0.998	0.000
I95.1 Orthostatic hypotension	0.000	0.998	0.002
Chapter XX External causes of morbidity and mortality	0.002	0.998	0.000
R18 Ascites	0.002	0.998	0.000
M54.22 Cervicalgia (Cervical region)	0.000	0.998	0.002
M54.97 Dorsalgia, unspecified (Lumbosacral region)	0.000	0.998	0.002
M54.95 Dorsalgia, unspecified (Thoracolumbar region)	0.000	0.998	0.002
M54.94 Dorsalgia, unspecified (Thoracic region)	0.000	0.998	0.002
M54.93 Dorsalgia, unspecified (Cervicothoracic region)	0.000	0.998	0.002
M54.92 Dorsalgia, unspecified (Cervical region)	0.000	0.998	0.002
M54.91 Dorsalgia, unspecified (Occipito-atlanto-axial region)	0.000	0.998	0.002
M54.90 Dorsalgia, unspecified (Multiple sites in spine)	0.000	0.998	0.002
S70 Superficial injury of hip and thigh	0.002	0.998	0.000
E14 Unspecified diabetes mellitus	0.000	0.998	0.002
T79-T79 Certain early complications of trauma	0.002	0.998	0.000
S02.20 Fracture of nasal bones (closed)	0.002	0.998	0.000
E14.9 Without complications	0.000	0.998	0.002
N48.6 Balanitis xerotica obliterans	0.000	0.998	0.002
S71 Open wound of hip and thigh	0.002	0.998	0.000
T66-T78 Other and unspecified effects of external causes	0.002	0.998	0.000
K80.0 Calculus of gallbladder with acute cholecystitis	0.002	0.998	0.000
S09.8 Other specified injuries of head	0.002	0.998	0.000
S09.7 Multiple injuries of head	0.002	0.998	0.000
S09.2 Traumatic rupture of ear drum	0.002	0.998	0.000
S09.1 Injury of muscle and tendon of head	0.002	0.998	0.000
S09.0 Injury of blood vessels of head, not elsewhere classified	0.002	0.998	0.000
K80-K87 Disorders of gallbladder, biliary tract and pancreas	0.002	0.998	0.000
S90-S99 Injuries to the ankle and foot	0.002	0.998	0.000
Y60-Y69 Misadventures to patients during surgical and medical care	0.002	0.998	0.000
S05.1 Contusion of eyeball and orbital tissues	0.002	0.998	0.000
T33-T35 Frostbite	0.002	0.998	0.000
T26-T28 Burns and corrosions confined to eye and internal organs	0.002	0.998	0.000
T20-T25 Burns and corrosions of external body surface, specified by site	0.002	0.998	0.000
T00-T07 Injuries involving multiple body regions	0.002	0.998	0.000
S10-S19 Injuries to the neck	0.002	0.998	0.000
Y60.0 During surgical operation	0.002	0.998	0.000
K80 Cholelithiasis	0.002	0.998	0.000
Y60 Unintentional cut, puncture, perforation or haemorrhage during surgical and medical care	0.002	0.998	0.000
K86.0 Alcohol-induced chronic pancreatitis	0.002	0.998	0.000
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts	0.002	0.998	0.000
V23.9 Unspecified motorcycle rider injured in traffic accident	0.002	0.998	0.000
V23.5 Passenger injured in traffic accident	0.002	0.998	0.000
V23.3 Person injured while boarding or alighting	0.002	0.998	0.000
V23.2 Unspecified motorcycle rider injured in nontraffic accident	0.002	0.998	0.000
V23.1 Passenger injured in nontraffic accident	0.002	0.998	0.000
V23.0 Driver injured in nontraffic accident	0.002	0.998	0.000
K86 Other diseases of pancreas	0.002	0.998	0.000
T14 Injury of unspecified body region	0.002	0.998	0.000
S70.0 Contusion of hip	0.002	0.998	0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.002	0.998	0.000
S05.0 Injury of conjunctiva and corneal abrasion without mention of foreign body	0.002	0.998	0.000
E10 Insulin-dependent diabetes mellitus	0.000	0.998	0.002
S40-S49 Injuries to the shoulder and upper arm	0.002	0.998	0.000
C25.0 Head of pancreas	0.002	0.998	0.000
S02.2 Fracture of nasal bones	0.002	0.998	0.000
T17 Foreign body in respiratory tract	0.002	0.998	0.000
T32 Corrosions classified according to extent of body surface involved	0.002	0.998	0.000
T30 Burn and corrosion, body region unspecified	0.002	0.998	0.000
T29 Burns and corrosions of multiple body regions	0.002	0.998	0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use	0.002	0.998	0.000
S08 Traumatic amputation of part of head	0.002	0.998	0.000
S07 Crushing injury of head	0.002	0.998	0.000
S04 Injury of cranial nerves	0.002	0.998	0.000
S03 Dislocation, sprain and strain of joints and ligaments of head	0.002	0.998	0.000
T19 Foreign body in genito-urinary tract	0.002	0.998	0.000
T15 Foreign body on external eye	0.002	0.998	0.000
T16 Foreign body in ear	0.002	0.998	0.000
K86.8 Other specified diseases of pancreas	0.002	0.998	0.000
S71.1 Open wound of thigh	0.002	0.998	0.000
S79 Other and unspecified injuries of hip and thigh	0.002	0.998	0.000
S78 Traumatic amputation of hip and thigh	0.002	0.998	0.000
S77 Crushing injury of hip and thigh	0.002	0.998	0.000
S76 Injury of muscle and tendon at hip and thigh level	0.002	0.998	0.000
S75 Injury of blood vessels at hip and thigh level	0.002	0.998	0.000
S74 Injury of nerves at hip and thigh level	0.002	0.998	0.000
S73 Dislocation, sprain and strain of joint and ligaments of hip	0.002	0.998	0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.002	0.998	0.000
X58-X59 Accidental exposure to other and unspecified factors	0.002	0.998	0.000
W20-W49 Exposure to inanimate mechanical forces	0.002	0.998	0.000
T31.9 Burns involving 90% or more of body surface	0.002	0.998	0.000
T31.8 Burns involving 80-89% of body surface	0.002	0.998	0.000
T31.7 Burns involving 70-79% of body surface	0.002	0.998	0.000
T31.6 Burns involving 60-69% of body surface	0.002	0.998	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations