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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs157582
log Bayes Factor = 98.5206
Chromosome 19   position 45,396,219  (GRCh37) Explore rs157582 on Ensembl!
Variant rs157582 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E78.0 Pure hypercholesterolaemia
1.000 0.000 0.000
F00.9 Dementia in Alzheimer's disease, unspecified
1.000 0.000 0.000
G30.9 Alzheimer's disease, unspecified
1.000 0.000 0.000
I25.1 Atherosclerotic heart disease
1.000 0.000 0.000
R41.0 Disorientation, unspecified
1.000 0.000 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
1.000 0.000 0.000
F00 Dementia in Alzheimer's disease
1.000 0.000 0.000
F03 Unspecified dementia
1.000 0.000 0.000
G30 Alzheimer's disease
1.000 0.000 0.000
I25 Chronic ischaemic heart disease
1.000 0.000 0.000
R41 Other symptoms and signs involving cognitive functions and awareness
1.000 0.000 0.000
I20-I25 Ischaemic heart diseases
1.000 0.000 0.000
F00-F09 Organic, including symptomatic, mental disorders
1.000 0.000 0.000
F01.9 Vascular dementia, unspecified
1.000 0.000 0.000
F05 Delirium, not induced by alcohol and other psychoactive substances
1.000 0.000 0.000
G30-G32 Other degenerative diseases of the nervous system
1.000 0.000 0.000
F01 Vascular dementia
1.000 0.000 0.000
I21 Acute myocardial infarction
1.000 0.000 0.000
R41.8 Other and unspecified symptoms and signs involving cognitive functions and awareness
1.000 0.000 0.000
F05.9 Delirium, unspecified
1.000 0.000 0.000
I25.2 Old myocardial infarction
1.000 0.000 0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.999 0.001 0.000
I21.1 Acute transmural myocardial infarction of inferior wall
0.999 0.001 0.000
R29.6 Tendency to fall, not elsewhere classified
0.997 0.003 0.000
I20 Angina pectoris
0.997 0.003 0.000
R29 Other symptoms and signs involving the nervous and musculoskeletal systems
0.996 0.004 0.000
E78.5 Hyperlipidaemia, unspecified
0.995 0.005 0.000
I20.0 Unstable angina
0.991 0.009 0.000
I21.9 Acute myocardial infarction, unspecified
0.989 0.011 0.000
F02 Dementia in other diseases classified elsewhere
0.988 0.012 0.000
Chapter V Mental and behavioural disorders
0.986 0.014 0.000
G31.8 Other specified degenerative diseases of nervous system
0.986 0.014 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.986 0.014 0.000
Z95 Presence of cardiac and vascular implants and grafts
0.978 0.022 0.000
G31.9 Degenerative disease of nervous system, unspecified
0.977 0.023 0.000
Z95.5 Presence of coronary angioplasty implant and graft
0.976 0.024 0.000
Z95.1 Presence of aortocoronary bypass graft
0.975 0.025 0.000
R29.8 Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
0.974 0.026 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.972 0.028 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.971 0.029 0.000
Chapter IX Diseases of the circulatory system
0.971 0.029 0.000
E78.2 Mixed hyperlipidaemia
0.971 0.029 0.000
I20.9 Angina pectoris, unspecified
0.970 0.030 0.000
I60-I69 Cerebrovascular diseases
0.969 0.031 0.000
Chapter VI Diseases of the nervous system
0.968 0.032 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.968 0.032 0.000
# Top node
0.966 0.034 0.000
Z95.0 Presence of cardiac pacemaker
0.965 0.035 0.000
E78.4 Other hyperlipidaemia
0.964 0.036 0.000
R41.3 Other amnesia
0.963 0.037 0.000
E70-E90 Metabolic disorders
0.960 0.040 0.000
I67 Other cerebrovascular diseases
0.951 0.049 0.000
F05.0 Delirium not superimposed on dementia, so described
0.950 0.050 0.000
G30.0 Alzheimer's disease with early onset
0.949 0.051 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.948 0.052 0.000
F06 Other mental disorders due to brain damage and dysfunction and to physical disease
0.948 0.052 0.000
G40-G47 Episodic and paroxysmal disorders
0.945 0.055 0.000
I25.8 Other forms of chronic ischaemic heart disease
0.944 0.056 0.000
I67.8 Other specified cerebrovascular diseases
0.943 0.057 0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.943 0.057 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.941 0.059 0.000
F02.8 Dementia in other specified diseases classified elsewhere
0.937 0.063 0.000
I61 Intracerebral haemorrhage
0.935 0.065 0.000
F00.2 Dementia in Alzheimer's disease, atypical or mixed type
0.933 0.067 0.000
R44.1 Visual hallucinations
0.927 0.073 0.000
G30.8 Other Alzheimer's disease
0.926 0.074 0.000
I65.2 Occlusion and stenosis of carotid artery
0.924 0.076 0.000
F00.0 Dementia in Alzheimer's disease with early onset
0.916 0.084 0.000
Z95.4 Presence of other heart-valve replacement
0.912 0.088 0.000
G45 Transient cerebral ischaemic attacks and related syndromes
0.912 0.088 0.000
E78.1 Pure hyperglyceridaemia
0.894 0.106 0.000
F05.1 Delirium superimposed on dementia
0.894 0.106 0.000
G31.0 Circumscribed brain atrophy
0.894 0.106 0.000
G44 Other headache syndromes
0.893 0.107 0.000
F05.8 Other delirium
0.892 0.108 0.000
G45.9 Transient cerebral ischaemic attack, unspecified
0.888 0.112 0.000
F06.7 Mild cognitive disorder
0.887 0.113 0.000
I67.2 Cerebral atherosclerosis
0.886 0.114 0.000
F02.3 Dementia in Parkinson's disease
0.876 0.124 0.000
F02.0 Dementia in Pick's disease
0.867 0.133 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.862 0.138 0.000
G41 Status epilepticus
0.861 0.139 0.000
R44.3 Hallucinations, unspecified
0.859 0.141 0.000
I25.9 Chronic ischaemic heart disease, unspecified
0.858 0.142 0.000
F29 Unspecified nonorganic psychosis
0.854 0.146 0.000
F00.1 Dementia in Alzheimer's disease with late onset
0.852 0.148 0.000
G30.1 Alzheimer's disease with late onset
0.847 0.153 0.000
I22 Subsequent myocardial infarction
0.846 0.154 0.000
E85 Amyloidosis
0.845 0.155 0.000
R46 Symptoms and signs involving appearance and behaviour
0.843 0.157 0.000
F07 Personality and behavioural disorders due to brain disease, damage and dysfunction
0.841 0.159 0.000
I61.1 Intracerebral haemorrhage in hemisphere, cortical
0.839 0.161 0.000
G32 Other degenerative disorders of nervous system in diseases classified elsewhere
0.835 0.165 0.000
E50-E64 Other nutritional deficiencies
0.829 0.171 0.000
I61.9 Intracerebral haemorrhage, unspecified
0.826 0.174 0.000
F25 Schizoaffective disorders
0.819 0.181 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.812 0.188 0.000
G44.0 Cluster headache syndrome
0.812 0.188 0.000
R27 Other lack of coordination
0.807 0.193 0.000
F09 Unspecified organic or symptomatic mental disorder
0.805 0.195 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.801 0.199 0.000
I61.4 Intracerebral haemorrhage in cerebellum
0.800 0.200 0.000
F60-F69 Disorders of adult personality and behaviour
0.795 0.205 0.000
E78.3 Hyperchylomicronaemia
0.792 0.208 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.787 0.213 0.000
G70-G73 Diseases of myoneural junction and muscle
0.786 0.214 0.000
I21.2 Acute transmural myocardial infarction of other sites
0.784 0.216 0.000
E80.4 Gilbert's syndrome
0.781 0.219 0.000
I21.0 Acute transmural myocardial infarction of anterior wall
0.777 0.223 0.000
R29.0 Tetany
0.776 0.224 0.000
F80-F89 Disorders of psychological development
0.773 0.227 0.000
F23 Acute and transient psychotic disorders
0.772 0.228 0.000
I22.1 Subsequent myocardial infarction of inferior wall
0.769 0.231 0.000
F06.2 Organic delusional [schizophrenia-like] disorder
0.766 0.234 0.000
G45.0 Vertebro-basilar artery syndrome
0.762 0.238 0.000
R29.1 Meningismus
0.761 0.239 0.000
G44.2 Tension-type headache
0.759 0.241 0.000
E85.4 Organ-limited amyloidosis
0.758 0.242 0.000
Z95.8 Presence of other cardiac and vascular implants and grafts
0.758 0.242 0.000
E78.6 Lipoprotein deficiency
0.757 0.243 0.000
G41.9 Status epilepticus, unspecified
0.756 0.244 0.000
F22 Persistent delusional disorders
0.756 0.244 0.000
R44.2 Other hallucinations
0.756 0.244 0.000
F30-F39 Mood [affective] disorders
0.750 0.250 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.746 0.254 0.000
R44.8 Other and unspecified symptoms and signs involving general sensations and perceptions
0.744 0.256 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.742 0.258 0.000
I25.3 Aneurysm of heart
0.742 0.258 0.000
G44.1 Vascular headache, not elsewhere classified
0.736 0.264 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.733 0.267 0.000
I61.2 Intracerebral haemorrhage in hemisphere, unspecified
0.727 0.273 0.000
R44.0 Auditory hallucinations
0.725 0.275 0.000
I61.8 Other intracerebral haemorrhage
0.723 0.277 0.000
I22.0 Subsequent myocardial infarction of anterior wall
0.722 0.278 0.000
E78.8 Other disorders of lipoprotein metabolism
0.720 0.280 0.000
G41.0 Grand mal status epilepticus
0.719 0.281 0.000
Z95.3 Presence of xenogenic heart valve
0.717 0.283 0.000
I25.6 Silent myocardial ischaemia
0.717 0.283 0.000
F04 Organic amnesic syndrome, not induced by alcohol and other psychoactive substances
0.717 0.283 0.000
F01.8 Other vascular dementia
0.717 0.283 0.000
F01.3 Mixed cortical and subcortical vascular dementia
0.717 0.283 0.000
F01.2 Subcortical vascular dementia
0.717 0.283 0.000
F01.1 Multi-infarct dementia
0.717 0.283 0.000
F01.0 Vascular dementia of acute onset
0.717 0.283 0.000
I21.X Presumed acute myicardial infaction (unconfirmed)
0.717 0.283 0.000
G32.8 Other specified degenerative disorders of nervous system in diseases classified elsewhere
0.717 0.283 0.000
G31.1 Senile degeneration of brain, not elsewhere classified
0.716 0.283 0.000
G46 Vascular syndromes of brain in cerebrovascular diseases
0.715 0.285 0.000
I05-I09 Chronic rheumatic heart diseases
0.715 0.285 0.000
I65.8 Occlusion and stenosis of other precerebral artery
0.714 0.286 0.000
R29.4 Clicking hip
0.714 0.286 0.000
R29.3 Abnormal posture
0.714 0.286 0.000
R29.2 Abnormal reflex
0.714 0.286 0.000
F99-F99 Unspecified mental disorder
0.709 0.291 0.000
F02.4 Dementia in human immunodeficiency virus [HIV] disease
0.708 0.292 0.000
F02.2 Dementia in Huntington's disease
0.708 0.292 0.000
F02.1 Dementia in Creutzfeldt-Jakob disease
0.708 0.292 0.000
E51 Thiamine deficiency
0.707 0.292 0.000
E74 Other disorders of carbohydrate metabolism
0.707 0.293 0.000
I00-I02 Acute rheumatic fever
0.707 0.293 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.707 0.293 0.000
G31.2 Degeneration of nervous system due to alcohol
0.706 0.294 0.000
R46.8 Other symptoms and signs involving appearance and behaviour
0.706 0.294 0.000
F06.9 Unspecified mental disorder due to brain damage and dysfunction and to physical disease
0.704 0.296 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.700 0.300 0.000
R27.0 Ataxia, unspecified
0.700 0.300 0.000
I23 Certain current complications following acute myocardial infarction
0.698 0.302 0.000
I61.6 Intracerebral haemorrhage, multiple localised
0.696 0.304 0.000
G70 Myasthenia gravis and other myoneural disorders
0.696 0.304 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.694 0.306 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.693 0.307 0.000
I24 Other acute ischaemic heart diseases
0.692 0.308 0.000
F25.2 Schizoaffective disorder, mixed type
0.691 0.309 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.689 0.311 0.000
I21.4 Acute subendocardial myocardial infarction
0.688 0.312 0.000
E84 Cystic fibrosis
0.688 0.312 0.000
E79 Disorders of purine and pyrimidine metabolism
0.688 0.312 0.000
E77 Disorders of glycoprotein metabolism
0.688 0.312 0.000
E76 Disorders of glycosaminoglycan metabolism
0.688 0.312 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.688 0.312 0.000
E72 Other disorders of amino-acid metabolism
0.688 0.312 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.688 0.312 0.000
E70 Disorders of aromatic amino-acid metabolism
0.688 0.312 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.688 0.312 0.000
F07.9 Unspecified organic personality and behavioural disorder due to brain disease, damage and dysfunction
0.686 0.314 0.000
Chapter XXII Codes for special purposes
0.686 0.314 0.000
G40 Epilepsy
0.685 0.315 0.000
F39 Unspecified mood [affective] disorder
0.683 0.317 0.000
I67.7 Cerebral arteritis, not elsewhere classified
0.682 0.318 0.000
I67.6 Nonpyogenic thrombosis of intracranial venous system
0.682 0.318 0.000
I67.5 Moyamoya disease
0.682 0.318 0.000
I67.4 Hypertensive encephalopathy
0.682 0.318 0.000
I67.3 Progressive vascular leukoencephalopathy
0.682 0.318 0.000
I68.0 Cerebral amyloid angiopathy
0.681 0.319 0.000
F06.8 Other specified mental disorders due to brain damage and dysfunction and to physical disease
0.679 0.320 0.000
F06.6 Organic emotionally labile [asthenic] disorder
0.679 0.320 0.000
F06.5 Organic dissociative disorder
0.679 0.320 0.000
F06.4 Organic anxiety disorder
0.679 0.320 0.000
F06.3 Organic mood [affective] disorders
0.679 0.320 0.000
F06.1 Organic catatonic disorder
0.679 0.320 0.000
F06.0 Organic hallucinosis
0.679 0.320 0.000
I65.9 Occlusion and stenosis of unspecified precerebral artery
0.676 0.324 0.000
I65.1 Occlusion and stenosis of basilar artery
0.676 0.324 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.675 0.324 0.000
F28 Other nonorganic psychotic disorders
0.674 0.326 0.000
F24 Induced delusional disorder
0.674 0.326 0.000
F21 Schizotypal disorder
0.674 0.326 0.000
F70-F79 Mental retardation
0.672 0.328 0.000
I25.4 Coronary artery aneurysm
0.672 0.328 0.000
E61 Deficiency of other nutrient elements
0.672 0.328 0.000
G45.1 Carotid artery syndrome (hemispheric)
0.667 0.332 0.000
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.667 0.333 0.000
F07.2 Postconcussional syndrome
0.665 0.335 0.000
G40.3 Generalised idiopathic epilepsy and epileptic syndromes
0.665 0.335 0.000
E85.3 Secondary systemic amyloidosis
0.663 0.337 0.000
F23.9 Acute and transient psychotic disorder, unspecified
0.660 0.340 0.000
I65.3 Occlusion and stenosis of multiple and bilateral precerebral arteries
0.659 0.341 0.000
G45.2 Multiple and bilateral precerebral artery syndromes
0.654 0.346 0.000
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.652 0.348 0.000
I65.0 Occlusion and stenosis of vertebral artery
0.651 0.349 0.000
F25.1 Schizoaffective disorder, depressive type
0.648 0.351 0.000
F69 Unspecified disorder of adult personality and behaviour
0.645 0.355 0.000
R46.2 Strange and inexplicable behaviour
0.645 0.355 0.000
R84 Abnormal findings in specimens from respiratory organs and thorax
0.642 0.358 0.000
G45.3 Amaurosis fugax
0.641 0.359 0.000
G44.3 Chronic posttraumatic headache
0.640 0.359 0.000
E80.6 Other disorders of bilirubin metabolism
0.640 0.359 0.000
I64 Stroke, not specified as haemorrhage or infarction
0.638 0.362 0.000
G70.0 Myasthenia gravis
0.638 0.362 0.000
F60 Specific personality disorders
0.637 0.363 0.000
F33 Recurrent depressive disorder
0.637 0.363 0.000
E80.1 Porphyria cutanea tarda
0.634 0.366 0.000
I24.8 Other forms of acute ischaemic heart disease
0.633 0.367 0.000
R86 Abnormal findings in specimens from male genital organs
0.631 0.369 0.000
F22.9 Persistent delusional disorder, unspecified
0.629 0.371 0.000
I61.0 Intracerebral haemorrhage in hemisphere, subcortical
0.627 0.373 0.000
E55 Vitamin D deficiency
0.623 0.377 0.000
R46.0 Very low level of personal hygiene
0.623 0.377 0.000
I06 Rheumatic aortic valve diseases
0.622 0.378 0.000
E51.2 Wernicke's encephalopathy
0.621 0.379 0.000
R83 Abnormal findings in cerebrospinal fluid
0.620 0.380 0.000
I67.0 Dissection of cerebral arteries, nonruptured
0.618 0.381 0.000
E80.7 Disorder of bilirubin metabolism, unspecified
0.618 0.382 0.000
E80.5 Crigler-Najjar syndrome
0.618 0.382 0.000
E80.3 Defects of catalase and peroxydase
0.618 0.382 0.000
E80.0 Hereditary erythropoietic porphyria
0.618 0.382 0.000
G41.8 Other status epilepticus
0.617 0.383 0.000
G41.2 Complex partial status epilepticus
0.617 0.383 0.000
G41.1 Petit mal status epilepticus
0.617 0.383 0.000
F81 Specific developmental disorders of scholastic skills
0.615 0.385 0.000
I20.8 Other forms of angina pectoris
0.614 0.386 0.000
R82 Other abnormal findings in urine
0.614 0.386 0.000
E89.4 Postprocedural ovarian failure
0.613 0.387 0.000
E56 Other vitamin deficiencies
0.613 0.387 0.000
E80.2 Other porphyria
0.612 0.387 0.000
R46.4 Slowness and poor responsiveness
0.612 0.388 0.000
R41.1 Anterograde amnesia
0.610 0.390 0.000
R80 Isolated proteinuria
0.610 0.390 0.000
R89 Abnormal findings in specimens from other organs, systems and tissues
0.610 0.390 0.000
R85 Abnormal findings in specimens from digestive organs and abdominal cavity
0.609 0.391 0.000
E85.8 Other amyloidosis
0.606 0.394 0.000
E85.2 Heredofamilial amyloidosis, unspecified
0.606 0.394 0.000
E85.1 Neuropathic heredofamilial amyloidosis
0.606 0.394 0.000
E85.0 Nonneuropathic heredofamilial amyloidosis
0.606 0.394 0.000
R46.7 Verbosity and circumstantial detail obscuring reason for contact
0.604 0.395 0.000
R46.6 Undue concern and preoccupation with stressful events
0.604 0.395 0.000
R46.5 Suspiciousness and marked evasiveness
0.604 0.395 0.000
R46.3 Overactivity
0.604 0.395 0.000
R46.1 Bizarre personal appearance
0.604 0.395 0.000
G44.4 Drug-induced headache, not elsewhere classified
0.604 0.395 0.000
I61.3 Intracerebral haemorrhage in brain stem
0.603 0.397 0.000
F07.8 Other organic personality and behavioural disorders due to brain disease, damage and dysfunction
0.603 0.397 0.000
F07.1 Postencephalitic syndrome
0.603 0.397 0.000
F07.0 Organic personality disorder
0.603 0.397 0.000
I62 Other nontraumatic intracranial haemorrhage
0.599 0.401 0.000
F25.9 Schizoaffective disorder, unspecified
0.599 0.401 0.000
G32.0 Subacute combined degeneration of spinal cord in diseases classified elsewhere
0.599 0.401 0.000
R41.2 Retrograde amnesia
0.596 0.404 0.000
G45.4 Transient global amnesia
0.595 0.405 0.000
F25.0 Schizoaffective disorder, manic type
0.594 0.406 0.000
E64 Sequelae of malnutrition and other nutritional deficiencies
0.594 0.406 0.000
E63 Other nutritional deficiencies
0.594 0.406 0.000
E50 Vitamin A deficiency
0.594 0.406 0.000
E60 Dietary zinc deficiency
0.594 0.406 0.000
E59 Dietary selenium deficiency
0.594 0.406 0.000
E58 Dietary calcium deficiency
0.594 0.406 0.000
E54 Ascorbic acid deficiency
0.594 0.406 0.000
E52 Niacin deficiency [pellagra]
0.594 0.406 0.000
I69 Sequelae of cerebrovascular disease
0.593 0.407 0.000
E40-E46 Malnutrition
0.592 0.408 0.000
G44.8 Other specified headache syndromes
0.587 0.412 0.000
F25.8 Other schizoaffective disorders
0.587 0.413 0.000
E87.3 Alkalosis
0.587 0.413 0.000
I66.3 Occlusion and stenosis of cerebellar arteries
0.582 0.418 0.000
R81 Glycosuria
0.578 0.422 0.000
R45 Symptoms and signs involving emotional state
0.577 0.423 0.000
E87.0 Hyperosmolality and hypernatraemia
0.575 0.425 0.000
I68.8 Other cerebrovascular disorders in diseases classified elsewhere
0.574 0.425 0.000
I68.2 Cerebral arteritis in other diseases classified elsewhere
0.574 0.425 0.000
I68.1 Cerebral arteritis in infectious and parasitic diseases classified elsewhere
0.574 0.425 0.000
F80 Specific developmental disorders of speech and language
0.574 0.426 0.000
F68 Other disorders of adult personality and behaviour
0.570 0.430 0.000
F66 Psychological and behavioural disorders associated with sexual development and orientation
0.570 0.430 0.000
F65 Disorders of sexual preference
0.570 0.430 0.000
F63 Habit and impulse disorders
0.570 0.430 0.000
F62 Enduring personality changes, not attributable to brain damage and disease
0.570 0.430 0.000
F61 Mixed and other personality disorders
0.570 0.430 0.000
G46.4 Cerebellar stroke syndrome
0.569 0.431 0.000
E73 Lactose intolerance
0.566 0.434 0.000
G20-G26 Extrapyramidal and movement disorders
0.565 0.435 0.000
I08 Multiple valve diseases
0.564 0.436 0.000
G73 Disorders of myoneural junction and muscle in diseases classified elsewhere
0.563 0.436 0.000
G14 Postpolio syndrome
0.561 0.439 0.000
E61.1 Iron deficiency
0.560 0.440 0.000
G40.0 Localisation-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localised onset
0.559 0.441 0.000
I66.0 Occlusion and stenosis of middle cerebral artery
0.558 0.442 0.000
R27.8 Other and unspecified lack of coordination
0.556 0.444 0.000
E88 Other metabolic disorders
0.555 0.445 0.000
F89 Unspecified disorder of psychological development
0.554 0.446 0.000
F88 Other disorders of psychological development
0.554 0.446 0.000
F83 Mixed specific developmental disorders
0.554 0.446 0.000
F82 Specific developmental disorder of motor function
0.554 0.446 0.000
F23.8 Other acute and transient psychotic disorders
0.553 0.446 0.000
F23.3 Other acute predominantly delusional psychotic disorders
0.553 0.446 0.000
F23.2 Acute schizophrenia-like psychotic disorder
0.553 0.446 0.000
F23.1 Acute polymorphic psychotic disorder with symptoms of schizophrenia
0.553 0.446 0.000
F60.5 Anankastic personality disorder
0.554 0.446 0.000
E85.9 Amyloidosis, unspecified
0.551 0.449 0.000
G40.6 Grand mal seizures, unspecified (with or without petit mal)
0.550 0.450 0.000
G71 Primary disorders of muscles
0.549 0.451 0.000
G45.8 Other transient cerebral ischaemic attacks and related syndromes
0.549 0.451 0.000
I09 Other rheumatic heart diseases
0.545 0.455 0.000
F22.8 Other persistent delusional disorders
0.542 0.458 0.000
F34 Persistent mood [affective] disorders
0.542 0.458 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.541 0.459 0.000
F84 Pervasive developmental disorders
0.540 0.459 0.000
G10 Huntington's disease
0.540 0.460 0.000
F38 Other mood [affective] disorders
0.538 0.462 0.000
I61.5 Intracerebral haemorrhage, intraventricular
0.537 0.463 0.000
F23.0 Acute polymorphic psychotic disorder without symptoms of schizophrenia
0.536 0.464 0.000
I66.8 Occlusion and stenosis of other cerebral artery
0.535 0.465 0.000
I66.4 Occlusion and stenosis of multiple and bilateral cerebral arteries
0.535 0.465 0.000
I66.2 Occlusion and stenosis of posterior cerebral artery
0.535 0.465 0.000
I66.1 Occlusion and stenosis of anterior cerebral artery
0.535 0.465 0.000
F22.0 Delusional disorder
0.533 0.466 0.000
F33.3 Recurrent depressive disorder, current episode severe with psychotic symptoms
0.529 0.471 0.000
I25.5 Ischaemic cardiomyopathy
0.528 0.472 0.000
R82.7 Abnormal findings on microbiological examination of urine
0.527 0.473 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.527 0.473 0.000
E74.3 Other disorders of intestinal carbohydrate absorption
0.526 0.473 0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.526 0.474 0.000
E89.8 Other postprocedural endocrine and metabolic disorders
0.526 0.474 0.000
E89.5 Postprocedural testicular hypofunction
0.526 0.474 0.000
E89.1 Postprocedural hypoinsulinaemia
0.526 0.474 0.000
R43 Disturbances of smell and taste
0.525 0.475 0.000
I06.0 Rheumatic aortic stenosis
0.523 0.477 0.000
F50 Eating disorders
0.522 0.477 0.000
R87 Abnormal findings in specimens from female genital organs
0.522 0.478 0.000
E53 Deficiency of other B group vitamins
0.521 0.479 0.000
R84.5 Abnormal microbiological findings
0.520 0.479 0.000
I00 Rheumatic fever without mention of heart involvement
0.518 0.482 0.000
I69.3 Sequelae of cerebral infarction
0.515 0.485 0.000
I66.9 Occlusion and stenosis of unspecified cerebral artery
0.514 0.485 0.000
G46.8 Other vascular syndromes of brain in cerebrovascular diseases
0.512 0.487 0.000
G46.6 Pure sensory lacunar syndrome
0.512 0.487 0.000
G46.5 Pure motor lacunar syndrome
0.512 0.487 0.000
G46.3 Brain stem stroke syndrome
0.512 0.487 0.000
G46.2 Posterior cerebral artery syndrome
0.512 0.487 0.000
G46.1 Anterior cerebral artery syndrome
0.512 0.487 0.000
G46.0 Middle cerebral artery syndrome
0.512 0.487 0.000
F99 Mental disorder, not otherwise specified
0.511 0.489 0.000
Z95.2 Presence of prosthetic heart valve
0.510 0.490 0.000
E51.9 Thiamine deficiency, unspecified
0.507 0.493 0.000
E51.8 Other manifestations of thiamine deficiency
0.507 0.493 0.000
E51.1 Beriberi
0.507 0.493 0.000
E74.9 Disorder of carbohydrate metabolism, unspecified
0.507 0.493 0.000
E74.8 Other specified disorders of carbohydrate metabolism
0.507 0.493 0.000
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.507 0.493 0.000
E74.2 Disorders of galactose metabolism
0.507 0.493 0.000
E74.1 Disorders of fructose metabolism
0.507 0.493 0.000
E74.0 Glycogen storage disease
0.507 0.493 0.000
I02 Rheumatic chorea
0.507 0.493 0.000
I01 Rheumatic fever with heart involvement
0.507 0.493 0.000
F98 Other behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.507 0.493 0.000
F95 Tic disorders
0.507 0.493 0.000
F94 Disorders of social functioning with onset specific to childhood and adolescence
0.507 0.493 0.000
F93 Emotional disorders with onset specific to childhood
0.507 0.493 0.000
F92 Mixed disorders of conduct and emotions
0.507 0.493 0.000
F91 Conduct disorders
0.507 0.493 0.000
F90 Hyperkinetic disorders
0.507 0.493 0.000
I24.1 Dressler's syndrome
0.505 0.495 0.000
R85.5 Abnormal microbiological findings
0.505 0.495 0.000
F64 Gender identity disorders
0.504 0.496 0.000
F33.0 Recurrent depressive disorder, current episode mild
0.504 0.496 0.000
I06.1 Rheumatic aortic insufficiency
0.504 0.496 0.000
E89.2 Postprocedural hypoparathyroidism
0.502 0.498 0.000
G13 Systemic atrophies primarily affecting central nervous system in diseases classified elsewhere
0.502 0.498 0.000
F81.9 Developmental disorder of scholastic skills, unspecified
0.501 0.499 0.000
F60.7 Dependent personality disorder
0.501 0.499 0.000
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.501 0.499 0.000
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.501 0.499 0.000
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.501 0.499 0.000
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.501 0.499 0.000
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.501 0.499 0.000
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.501 0.499 0.000
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.501 0.499 0.000
G70.8 Other specified myoneural disorders
0.499 0.501 0.000
G70.2 Congenital and developmental myasthenia
0.499 0.501 0.000
G70.1 Toxic myoneural disorders
0.499 0.501 0.000
F33.2 Recurrent depressive disorder, current episode severe without psychotic symptoms
0.498 0.502 0.000
F33.4 Recurrent depressive disorder, currently in remission
0.498 0.502 0.000
F51 Nonorganic sleep disorders
0.498 0.502 0.000
R96 Other sudden death, cause unknown
0.497 0.502 0.000
R95 Sudden infant death syndrome
0.497 0.502 0.000
R99 Other ill-defined and unspecified causes of mortality
0.497 0.502 0.000
R98 Unattended death
0.497 0.502 0.000
P90-P96 Other disorders originating in the perinatal period
0.497 0.503 0.000
P80-P83 Conditions involving the integument and temperature regulation of fetus and newborn
0.497 0.503 0.000
P75-P78 Digestive system disorders of fetus and newborn
0.497 0.503 0.000
P70-P74 Transitory endocrine and metabolic disorders specific to fetus and newborn
0.497 0.503 0.000
P50-P61 Haemorrhagic and haematological disorders of fetus and newborn
0.497 0.503 0.000
P35-P39 Infections specific to the perinatal period
0.497 0.503 0.000
P20-P29 Respiratory and cardiovascular disorders specific to the perinatal period
0.497 0.503 0.000
P10-P15 Birth trauma
0.497 0.503 0.000
P05-P08 Disorders related to length of gestation and fetal growth
0.497 0.503 0.000
P00-P04 Fetus and newborn affected by maternal factors and by complications of pregnancy, labour and delivery
0.497 0.503 0.000
E87.4 Mixed disorder of acid-base balance
0.494 0.506 0.000
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.493 0.507 0.000
E70.8 Other disorders of aromatic amino-acid metabolism
0.493 0.507 0.000
E70.3 Albinism
0.493 0.507 0.000
E70.2 Disorders of tyrosine metabolism
0.493 0.507 0.000
E70.1 Other hyperphenylalaninaemias
0.493 0.507 0.000
E70.0 Classical phenylketonuria
0.493 0.507 0.000
E71.3 Disorders of fatty-acid metabolism
0.493 0.507 0.000
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.493 0.507 0.000
E71.1 Other disorders of branched-chain amino-acid metabolism
0.493 0.507 0.000
E71.0 Maple-syrup-urine disease
0.493 0.507 0.000
E72.9 Disorder of amino-acid metabolism, unspecified
0.493 0.507 0.000
E72.8 Other specified disorders of amino-acid metabolism
0.493 0.507 0.000
E72.5 Disorders of glycine metabolism
0.493 0.507 0.000
E72.4 Disorders of ornithine metabolism
0.493 0.507 0.000
E72.3 Disorders of lysine and hydroxylysine metabolism
0.493 0.507 0.000
E72.2 Disorders of urea cycle metabolism
0.493 0.507 0.000
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.493 0.507 0.000
E72.0 Disorders of amino-acid transport
0.493 0.507 0.000
E75.6 Lipid storage disorder, unspecified
0.493 0.507 0.000
E75.5 Other lipid storage disorders
0.493 0.507 0.000
E75.4 Neuronal ceroid lipofuscinosis
0.493 0.507 0.000
E75.3 Sphingolipidosis, unspecified
0.493 0.507 0.000
E75.2 Other sphingolipidosis
0.493 0.507 0.000
E75.1 Other gangliosidosis
0.493 0.507 0.000
E75.0 GM2 gangliosidosis
0.493 0.507 0.000
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.493 0.507 0.000
E76.8 Other disorders of glucosaminoglycan metabolism
0.493 0.507 0.000
E76.3 Mucopolysaccharidosis, unspecified
0.493 0.507 0.000
E76.2 Other mucopolysaccharidoses
0.493 0.507 0.000
E76.1 Mucopolysaccharidosis, type II
0.493 0.507 0.000
E76.0 Mucopolysaccharidosis, type I
0.493 0.507 0.000
E77.9 Disorder of glycoprotein metabolism, unspecified
0.493 0.507 0.000
E77.8 Other disorders of glycoprotein metabolism
0.493 0.507 0.000
E77.1 Defects in glycoprotein degradation
0.493 0.507 0.000
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.493 0.507 0.000
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.493 0.507 0.000
E79.8 Other disorders of purine and pyrimidine metabolism
0.493 0.507 0.000
E79.1 Lesch-Nyhan syndrome
0.493 0.507 0.000
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.493 0.507 0.000
E84.9 Cystic fibrosis, unspecified
0.493 0.507 0.000
E84.8 Cystic fibrosis with other manifestations
0.493 0.507 0.000
E84.1 Cystic fibrosis with intestinal manifestations
0.493 0.507 0.000
E84.0 Cystic fibrosis with pulmonary manifestations
0.493 0.507 0.000
F32 Depressive episode
0.493 0.507 0.000
G40.4 Other generalised epilepsy and epileptic syndromes
0.491 0.509 0.000
U82-U85 Resistance to antimicrobial and antineoplastic drugs
0.490 0.510 0.000
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.490 0.510 0.000
E78.9 Disorder of lipoprotein metabolism, unspecified
0.489 0.511 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.486 0.514 0.000
G46.7 Other lacunar syndromes
0.485 0.515 0.000
F60.3 Emotionally unstable personality disorder
0.485 0.515 0.000
R45.6 Physical violence
0.485 0.515 0.000
F53 Mental and behavioural disorders associated with the puerperium, not elsewhere classified
0.484 0.515 0.000
F59 Unspecified behavioural syndromes associated with physiological disturbances and physical factors
0.484 0.515 0.000
F55 Abuse of non-dependence-producing substances
0.484 0.515 0.000
F54 Psychological and behavioural factors associated with disorders or diseases classified elsewhere
0.484 0.515 0.000
R86.9 Unspecified abnormal finding
0.484 0.516 0.000
G72 Other myopathies
0.483 0.517 0.000
I23.8 Other current complications following acute myocardial infarction
0.482 0.518 0.000
F78 Other mental retardation
0.482 0.518 0.000
F73 Profound mental retardation
0.482 0.518 0.000
F72 Severe mental retardation
0.482 0.518 0.000
F71 Moderate mental retardation
0.482 0.518 0.000
F70 Mild mental retardation
0.482 0.518 0.000
E61.9 Deficiency of nutrient element, unspecified
0.482 0.518 0.000
E61.8 Deficiency of other specified nutrient elements
0.482 0.518 0.000
E61.7 Deficiency of multiple nutrient elements
0.482 0.518 0.000
E61.6 Vanadium deficiency
0.482 0.518 0.000
E61.5 Molybdenum deficiency
0.482 0.518 0.000
E61.4 Chromium deficiency
0.482 0.518 0.000
E61.3 Manganese deficiency
0.482 0.518 0.000
E61.2 Magnesium deficiency
0.482 0.518 0.000
E61.0 Copper deficiency
0.482 0.518 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

This website was created, designed, and edited by ORCID iD iconPatrick K. Albers

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