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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs1634731
log Bayes Factor = 46.0704
Chromosome 6   position 30,955,681  (GRCh37) Explore rs1634731 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
L40 Psoriasis
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.001 0.999
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.001 0.999
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.001 0.999
E10.3 With ophthalmic complications
0.000 0.003 0.997
E03 Other hypothyroidism
0.000 0.003 0.997
E78.0 Pure hypercholesterolaemia
0.000 0.004 0.996
E05.9 Thyrotoxicosis, unspecified
0.000 0.004 0.996
E14 Unspecified diabetes mellitus
0.000 0.005 0.995
E03.9 Hypothyroidism, unspecified
0.000 0.005 0.995
E78.5 Hyperlipidaemia, unspecified
0.000 0.007 0.993
E70-E90 Metabolic disorders
0.000 0.009 0.991
E11 Non-insulin-dependent diabetes mellitus
0.000 0.010 0.990
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.012 0.988
E14.9 Without complications
0.000 0.014 0.986
I20-I25 Ischaemic heart diseases
0.000 0.018 0.982
G35 Multiple sclerosis
0.981 0.019 0.000
I25 Chronic ischaemic heart disease
0.000 0.020 0.980
E16 Other disorders of pancreatic internal secretion
0.000 0.020 0.980
E11.9 Without complications
0.000 0.021 0.979
I24 Other acute ischaemic heart diseases
0.000 0.024 0.976
E16.2 Hypoglycaemia, unspecified
0.000 0.027 0.973
E10.1 With ketoacidosis
0.000 0.030 0.970
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.030 0.970
E78.2 Mixed hyperlipidaemia
0.000 0.046 0.954
I22 Subsequent myocardial infarction
0.000 0.047 0.953
E10.4 With neurological complications
0.000 0.053 0.947
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.058 0.942
L40.0 Psoriasis vulgaris
0.000 0.079 0.921
I25.2 Old myocardial infarction
0.000 0.081 0.919
E11.0 With coma
0.000 0.086 0.914
E50-E64 Other nutritional deficiencies
0.000 0.092 0.908
E10.2 With renal complications
0.000 0.093 0.907
E07 Other disorders of thyroid
0.000 0.100 0.900
I21 Acute myocardial infarction
0.000 0.100 0.900
I24.8 Other forms of acute ischaemic heart disease
0.000 0.109 0.891
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.114 0.886
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.118 0.882
E78.8 Other disorders of lipoprotein metabolism
0.000 0.119 0.881
I21.4 Acute subendocardial myocardial infarction
0.000 0.138 0.862
E07.9 Disorder of thyroid, unspecified
0.000 0.143 0.857
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.145 0.855
E14.3 With ophthalmic complications
0.000 0.146 0.854
E61 Deficiency of other nutrient elements
0.000 0.147 0.853
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.151 0.849
E10.8 With unspecified complications
0.000 0.154 0.846
E10.0 With coma
0.000 0.155 0.845
E20-E35 Disorders of other endocrine glands
0.000 0.157 0.843
I25.5 Ischaemic cardiomyopathy
0.000 0.165 0.835
E11.1 With ketoacidosis
0.000 0.174 0.826
E10.5 With peripheral circulatory complications
0.000 0.179 0.821
E61.1 Iron deficiency
0.000 0.186 0.814
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.207 0.793
E11.5 With peripheral circulatory complications
0.000 0.209 0.791
L40-L45 Papulosquamous disorders
0.000 0.212 0.788
I21.9 Acute myocardial infarction, unspecified
0.000 0.217 0.783
E16.1 Other hypoglycaemia
0.000 0.220 0.780
E05.8 Other thyrotoxicosis
0.000 0.225 0.775
I25.1 Atherosclerotic heart disease
0.000 0.228 0.772
E10.6 With other specified complications
0.000 0.229 0.771
I23 Certain current complications following acute myocardial infarction
0.000 0.233 0.767
E55 Vitamin D deficiency
0.000 0.234 0.766
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.237 0.763
L43 Lichen planus
0.000 0.241 0.759
E14.4 With neurological complications
0.000 0.243 0.757
E14.1 With ketoacidosis
0.000 0.247 0.753
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.247 0.753
E78.1 Pure hyperglyceridaemia
0.000 0.252 0.748
I10-I15 Hypertensive diseases
0.000 0.253 0.747
I24.1 Dressler's syndrome
0.000 0.254 0.746
I10 Essential (primary) hypertension
0.000 0.255 0.745
E23 Hypofunction and other disorders of pituitary gland
0.000 0.255 0.745
Chapter IX Diseases of the circulatory system
0.000 0.256 0.744
E11.6 With other specified complications
0.000 0.257 0.743
I25.3 Aneurysm of heart
0.000 0.269 0.731
L43.9 Lichen planus, unspecified
0.000 0.272 0.728
E24 Cushing's syndrome
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
E78.6 Lipoprotein deficiency
0.000 0.284 0.716
E78.3 Hyperchylomicronaemia
0.000 0.284 0.716
E05.5 Thyroid crisis or storm
0.000 0.284 0.716
E05.4 Thyrotoxicosis factitia
0.000 0.284 0.716
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.284 0.716
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.284 0.716
E03.5 Myxoedema coma
0.000 0.285 0.715
E03.4 Atrophy of thyroid (acquired)
0.000 0.285 0.715
E03.3 Postinfectious hypothyroidism
0.000 0.285 0.715
E03.1 Congenital hypothyroidism without goitre
0.000 0.285 0.715
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.285 0.715
E14.8 With unspecified complications
0.000 0.286 0.714
E14.7 With multiple complications
0.000 0.286 0.714
E14.6 With other specified complications
0.000 0.286 0.714
E14.5 With peripheral circulatory complications
0.000 0.286 0.714
E14.2 Withrenal complications
0.000 0.286 0.714
E14.0 With coma
0.000 0.286 0.714
E79 Disorders of purine and pyrimidine metabolism
0.000 0.290 0.710
E77 Disorders of glycoprotein metabolism
0.000 0.290 0.710
E76 Disorders of glycosaminoglycan metabolism
0.000 0.290 0.710
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.290 0.710
E72 Other disorders of amino-acid metabolism
0.000 0.290 0.710
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.290 0.710
E70 Disorders of aromatic amino-acid metabolism
0.000 0.290 0.710
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.290 0.710
E11.7 With multiple complications
0.000 0.290 0.710
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.291 0.709
E15 Nondiabetic hypoglycaemic coma
0.000 0.291 0.709
E85 Amyloidosis
0.000 0.293 0.707
I25.6 Silent myocardial ischaemia
0.000 0.297 0.703
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.297 0.703
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.297 0.703
E16.4 Abnormal secretion of gastrin
0.000 0.297 0.703
E16.3 Increased secretion of glucagon
0.000 0.297 0.703
L40.1 Generalised pustular psoriasis
0.000 0.300 0.700
E21.3 Hyperparathyroidism, unspecified
0.000 0.301 0.699
E13 Other specified diabetes mellitus
0.000 0.309 0.691
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.309 0.691
E11.4 With neurological complications
0.000 0.322 0.678
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.322 0.678
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.325 0.675
G35-G37 Demyelinating diseases of the central nervous system
0.674 0.326 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.326 0.674
E74 Other disorders of carbohydrate metabolism
0.000 0.327 0.672
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.334 0.666
E78.4 Other hyperlipidaemia
0.000 0.334 0.665
E84 Cystic fibrosis
0.000 0.336 0.663
E55.9 Vitamin D deficiency, unspecified
0.000 0.336 0.664
L40.8 Other psoriasis
0.000 0.337 0.663
E23.0 Hypopituitarism
0.000 0.343 0.657
E06 Thyroiditis
0.000 0.344 0.655
E11.2 With renal complications
0.000 0.349 0.651
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.349 0.651
E63 Other nutritional deficiencies
0.000 0.349 0.651
E56 Other vitamin deficiencies
0.000 0.349 0.651
E51 Thiamine deficiency
0.000 0.349 0.651
E50 Vitamin A deficiency
0.000 0.349 0.651
E60 Dietary zinc deficiency
0.000 0.349 0.651
E59 Dietary selenium deficiency
0.000 0.349 0.651
E58 Dietary calcium deficiency
0.000 0.349 0.651
E54 Ascorbic acid deficiency
0.000 0.349 0.651
E52 Niacin deficiency [pellagra]
0.000 0.349 0.651
E73 Lactose intolerance
0.000 0.349 0.650
I74 Arterial embolism and thrombosis
0.000 0.352 0.648
I15 Secondary hypertension
0.000 0.353 0.647
E07.1 Dyshormogenetic goitre
0.000 0.354 0.645
E07.0 Hypersecretion of calcitonin
0.000 0.354 0.645
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.355 0.645
E28 Ovarian dysfunction
0.000 0.358 0.642
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.362 0.638
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.366 0.634
E83 Disorders of mineral metabolism
0.511 0.366 0.123
I70 Atherosclerosis
0.000 0.373 0.627
I25.4 Coronary artery aneurysm
0.000 0.375 0.625
I05-I09 Chronic rheumatic heart diseases
0.000 0.376 0.624
I22.8 Subsequent myocardial infarction of other sites
0.000 0.380 0.620
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.000 0.381 0.619
E03.8 Other specified hypothyroidism
0.000 0.383 0.617
E40-E46 Malnutrition
0.000 0.383 0.617
I23.8 Other current complications following acute myocardial infarction
0.000 0.387 0.612
L43.8 Other lichen planus
0.000 0.388 0.612
E61.9 Deficiency of nutrient element, unspecified
0.000 0.388 0.612
E61.8 Deficiency of other specified nutrient elements
0.000 0.388 0.612
E61.7 Deficiency of multiple nutrient elements
0.000 0.388 0.612
E61.6 Vanadium deficiency
0.000 0.388 0.612
E61.5 Molybdenum deficiency
0.000 0.388 0.612
E61.4 Chromium deficiency
0.000 0.388 0.612
E61.3 Manganese deficiency
0.000 0.388 0.612
E61.2 Magnesium deficiency
0.000 0.388 0.612
E61.0 Copper deficiency
0.000 0.388 0.612
I12 Hypertensive renal disease
0.000 0.389 0.611
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.396 0.604
E32 Diseases of thymus
0.000 0.396 0.604
E31 Polyglandular dysfunction
0.000 0.396 0.604
E30 Disorders of puberty, not elsewhere classified
0.000 0.396 0.604
E25 Adrenogenital disorders
0.000 0.396 0.604
E24.9 Cushing's syndrome, unspecified
0.000 0.396 0.604
G37 Other demyelinating diseases of central nervous system
0.602 0.398 0.000
I74.5 Embolism and thrombosis of iliac artery
0.000 0.414 0.586
E89.3 Postprocedural hypopituitarism
0.000 0.423 0.577
E22 Hyperfunction of pituitary gland
0.000 0.425 0.575
I70.0 Atherosclerosis of aorta
0.000 0.426 0.574
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.426 0.574
L44 Other papulosquamous disorders
0.000 0.435 0.565
L41 Parapsoriasis
0.000 0.435 0.565
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.435 0.565
E29 Testicular dysfunction
0.000 0.437 0.563
L40.3 Pustulosis palmaris et plantaris
0.000 0.437 0.562
E23.2 Diabetes insipidus
0.000 0.439 0.561
I15.1 Hypertension secondary to other renal disorders
0.000 0.442 0.558
E24.2 Drug-induced Cushing's syndrome
0.000 0.443 0.557
E11.8 With unspecified complications
0.000 0.447 0.552
I05 Rheumatic mitral valve diseases
0.000 0.448 0.552
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.450 0.550
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.450 0.550
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.450 0.550
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.450 0.550
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.450 0.550
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.450 0.550
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.450 0.550
E23.7 Disorder of pituitary gland, unspecified
0.000 0.450 0.550
E85.9 Amyloidosis, unspecified
0.000 0.451 0.549
E55.0 Rickets, active
0.000 0.451 0.549
E28.2 Polycystic ovarian syndrome
0.000 0.451 0.549
L43.3 Subacute (active) lichen planus
0.000 0.456 0.544
L43.2 Lichenoid drug reaction
0.000 0.456 0.544
L43.1 Bullous lichen planus
0.000 0.456 0.544
L43.0 Hypertrophic lichen planus
0.000 0.456 0.544
I70.2 Atherosclerosis of arteries of the extremities
0.000 0.458 0.542
E26 Hyperaldosteronism
0.000 0.459 0.541
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.459 0.541
I11 Hypertensive heart disease
0.000 0.460 0.540
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.460 0.540
E21.4 Other specified disorders of parathyroid gland
0.000 0.460 0.540
E21.2 Other hyperparathyroidism
0.000 0.460 0.540
I70.00 Atherosclerosis of aorta (without gangrene)
0.000 0.463 0.537
I13 Hypertensive heart and renal disease
0.000 0.464 0.536
E23.6 Other disorders of pituitary gland
0.000 0.465 0.535
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.466 0.534
E23.1 Drug-induced hypopituitarism
0.000 0.466 0.534
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.471 0.528
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.472 0.528
E20 Hypoparathyroidism
0.000 0.474 0.526
G37.8 Other specified demyelinating diseases of central nervous system
0.523 0.477 0.000
E88 Other metabolic disorders
0.000 0.478 0.522
E89.2 Postprocedural hypoparathyroidism
0.000 0.480 0.520
E24.8 Other Cushing's syndrome
0.000 0.485 0.514
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.485 0.514
E24.3 Ectopic ACTH syndrome
0.000 0.485 0.514
E24.1 Nelson's syndrome
0.000 0.485 0.514
E24.0 Pituitary-dependent Cushing's disease
0.000 0.485 0.514
I15.9 Seconday hypertension, unspecified
0.000 0.485 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
I00-I02 Acute rheumatic fever
0.000 0.487 0.512
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.491 0.509
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.491 0.509
E70.3 Albinism
0.000 0.491 0.509
E70.2 Disorders of tyrosine metabolism
0.000 0.491 0.509
E70.1 Other hyperphenylalaninaemias
0.000 0.491 0.509
E70.0 Classical phenylketonuria
0.000 0.491 0.509
E71.3 Disorders of fatty-acid metabolism
0.000 0.491 0.509
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.491 0.509
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.491 0.509
E71.0 Maple-syrup-urine disease
0.000 0.491 0.509
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.491 0.509
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.491 0.509
E72.5 Disorders of glycine metabolism
0.000 0.491 0.509
E72.4 Disorders of ornithine metabolism
0.000 0.491 0.509
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.491 0.509
E72.2 Disorders of urea cycle metabolism
0.000 0.491 0.509
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.491 0.509
E72.0 Disorders of amino-acid transport
0.000 0.491 0.509
E75.6 Lipid storage disorder, unspecified
0.000 0.491 0.509
E75.5 Other lipid storage disorders
0.000 0.491 0.509
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.491 0.509
E75.3 Sphingolipidosis, unspecified
0.000 0.491 0.509
E75.2 Other sphingolipidosis
0.000 0.491 0.509
E75.1 Other gangliosidosis
0.000 0.491 0.509
E75.0 GM2 gangliosidosis
0.000 0.491 0.509
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.491 0.509
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.491 0.509
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.491 0.509
E76.2 Other mucopolysaccharidoses
0.000 0.491 0.509
E76.1 Mucopolysaccharidosis, type II
0.000 0.491 0.509
E76.0 Mucopolysaccharidosis, type I
0.000 0.491 0.509
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.491 0.509
E77.8 Other disorders of glycoprotein metabolism
0.000 0.491 0.509
E77.1 Defects in glycoprotein degradation
0.000 0.491 0.509
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.491 0.509
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.491 0.509
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.491 0.509
E79.1 Lesch-Nyhan syndrome
0.000 0.491 0.509
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.491 0.509
E85.8 Other amyloidosis
0.000 0.493 0.507
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.493 0.507
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.493 0.507
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.493 0.507
I12.9 Hypertensive renal disease without renal failure
0.000 0.495 0.505
E83.3 Disorders of phosphorus metabolism
0.465 0.503 0.032
E13.8 With unspecified complications
0.000 0.504 0.496
E13.7 With multiple complications
0.000 0.504 0.496
E13.6 With other specified complications
0.000 0.504 0.496
E13.5 With peripheral circulatory complications
0.000 0.504 0.496
E13.4 With neurological complications
0.000 0.504 0.496
E13.3 With ophthalmic complications
0.000 0.504 0.496
E13.2 With renal complications
0.000 0.504 0.496
E13.1 With ketoacidosis
0.000 0.504 0.496
E13.0 With coma
0.000 0.504 0.496
I71 Aortic aneurysm and dissection
0.000 0.509 0.491
I74.9 Embolism and thrombosis of unspecified artery
0.000 0.512 0.488
E85.3 Secondary systemic amyloidosis
0.000 0.512 0.488
G37.9 Demyelinating disease of central nervous system, unspecified
0.484 0.516 0.000
G36 Other acute disseminated demyelination
0.483 0.516 0.000
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.518 0.482
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.518 0.482
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.518 0.482
E74.2 Disorders of galactose metabolism
0.000 0.518 0.482
E74.1 Disorders of fructose metabolism
0.000 0.518 0.482
E74.0 Glycogen storage disease
0.000 0.518 0.482
E07.8 Other specified disorders of thyroid
0.000 0.520 0.480
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.522 0.478
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.522 0.478
E89.5 Postprocedural testicular hypofunction
0.000 0.522 0.478
E89.1 Postprocedural hypoinsulinaemia
0.000 0.522 0.478
E34 Other endocrine disorders
0.000 0.523 0.477
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.000 0.523 0.477
E84.8 Cystic fibrosis with other manifestations
0.000 0.524 0.476
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.524 0.476
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.524 0.476
I09 Other rheumatic heart diseases
0.000 0.525 0.475
E85.4 Organ-limited amyloidosis
0.000 0.528 0.472
E06.5 Other chronic thyroiditis
0.000 0.530 0.470
E06.4 Drug-induced thyroiditis
0.000 0.530 0.470
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.530 0.470
E06.1 Subacute thyroiditis
0.000 0.530 0.470
E06.0 Acute thyroiditis
0.000 0.530 0.470
E13.9 Without complications
0.000 0.530 0.470
I05.2 Mitral stenosis with insufficiency
0.000 0.532 0.468
E50.9 Vitamin A deficiency, unspecified
0.000 0.533 0.467
E50.8 Other manifestations of vitamin A deficiency
0.000 0.533 0.467
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.533 0.467
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.533 0.467
E50.5 Vitamin A deficiency with night blindness
0.000 0.533 0.467
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.533 0.467
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.533 0.467
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.533 0.467
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.533 0.467
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.533 0.467
E51.9 Thiamine deficiency, unspecified
0.000 0.533 0.467
E51.8 Other manifestations of thiamine deficiency
0.000 0.533 0.467
E51.2 Wernicke's encephalopathy
0.000 0.533 0.467
E51.1 Beriberi
0.000 0.533 0.467
E56.9 Vitamin deficiency, unspecified
0.000 0.533 0.467
E56.8 Deficiency of other vitamins
0.000 0.533 0.467
E56.1 Deficiency of vitamin K
0.000 0.533 0.467
E56.0 Deficiency of vitamin E
0.000 0.533 0.467
E63.9 Nutritional deficiency, unspecified
0.000 0.533 0.467
E63.8 Other specified nutritional deficiencies
0.000 0.533 0.467
E63.1 Imbalance of constituents of food intake
0.000 0.533 0.467
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.533 0.467
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.533 0.467
E64.8 Sequelae of other nutritional deficiencies
0.000 0.533 0.467
E64.3 Sequelae of rickets
0.000 0.533 0.467
E64.2 Sequelae of vitamin C deficiency
0.000 0.533 0.467
E64.1 Sequelae of vitamin A deficiency
0.000 0.533 0.467
E64.0 Sequelae of protein-energy malnutrition
0.000 0.533 0.467
E73.8 Other lactose intolerance
0.000 0.533 0.466
E73.1 Secondary lactase deficiency
0.000 0.533 0.466
E73.0 Congenital lactase deficiency
0.000 0.533 0.466
I74.8 Embolism and thrombosis of other arteries
0.000 0.534 0.466
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.535 0.464
I15.8 Other secondary hypertension
0.000 0.536 0.464
I15.2 Hypertension secondary to endocrine disorders
0.000 0.536 0.464
E89.4 Postprocedural ovarian failure
0.000 0.538 0.462
E28.9 Ovarian dysfunction, unspecified
0.000 0.539 0.460
E28.8 Other ovarian dysfunction
0.000 0.539 0.460
E28.1 Androgen excess
0.000 0.539 0.460
E28.0 Oestrogen excess
0.000 0.539 0.460
L42 Pityriasis rosea
0.000 0.539 0.460
E06.3 Autoimmune thyroiditis
0.000 0.542 0.457
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.000 0.543 0.457
E83.9 Disorder of mineral metabolism, unspecified
0.367 0.545 0.088
E83.8 Other disorders of mineral metabolism
0.367 0.545 0.088
E83.2 Disorders of zinc metabolism
0.367 0.545 0.088
E83.0 Disorders of copper metabolism
0.367 0.545 0.088
I70.20 Atherosclerosis of arteries of extremities (without gangrene)
0.000 0.545 0.455
I05.0 Mitral stenosis
0.000 0.546 0.454
E21.0 Primary hyperparathyroidism
0.000 0.546 0.454
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.548 0.452
I12.0 Hypertensive renal disease with renal failure
0.000 0.549 0.451
I70.9 Generalised and unspecified atherosclerosis
0.000 0.550 0.450
I70.8 Atherosclerosis of other arteries
0.000 0.550 0.450
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.000 0.554 0.446
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.555 0.444
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.557 0.442
E45 Retarded development following protein-energy malnutrition
0.000 0.557 0.442
E43 Unspecified severe protein-energy malnutrition
0.000 0.557 0.442
E42 Marasmic kwashiorkor
0.000 0.557 0.442
E41 Nutritional marasmus
0.000 0.557 0.442
E40 Kwashiorkor
0.000 0.557 0.442
I15.0 Renovascular hypertension
0.000 0.558 0.442
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.440 0.559 0.000
I08 Multiple valve diseases
0.000 0.563 0.437
I70.21 Atherosclerosis of arteries of extremities (with gangrene)
0.000 0.564 0.435
E25.9 Adrenogenital disorder, unspecified
0.000 0.567 0.433
E25.8 Other adrenogenital disorders
0.000 0.567 0.433
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.567 0.433
E30.9 Disorder of puberty, unspecified
0.000 0.567 0.433
E30.8 Other disorders of puberty
0.000 0.567 0.433
E30.1 Precocious puberty
0.000 0.567 0.433
E30.0 Delayed puberty
0.000 0.567 0.433
E31.9 Polyglandular dysfunction, unspecified
0.000 0.567 0.433
E31.8 Other polyglandular dysfunction
0.000 0.567 0.433
E31.1 Polyglandular hyperfunction
0.000 0.567 0.433
E31.0 Autoimmune polyglandular failure
0.000 0.567 0.433
E32.9 Disease of thymus, unspecified
0.000 0.567 0.433
E32.8 Other diseases of thymus
0.000 0.567 0.433
E32.1 Abscess of thymus
0.000 0.567 0.433
E32.0 Persistent hyperplasia of thymus
0.000 0.567 0.433
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.567 0.433
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.567 0.433
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.567 0.433
G37.5 Concentric sclerosis [Balo]
0.432 0.568 0.000
G37.4 Subacute necrotising myelitis
0.432 0.568 0.000
G37.2 Central pontine myelinolysis
0.432 0.568 0.000
G37.1 Central demyelination of corpus callosum
0.432 0.568 0.000
G37.0 Diffuse sclerosis
0.432 0.568 0.000
I06 Rheumatic aortic valve diseases
0.000 0.569 0.431
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.000 0.570 0.430
E84.9 Cystic fibrosis, unspecified
0.000 0.571 0.429
E06.9 Thyroiditis, unspecified
0.000 0.576 0.424
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.000 0.577 0.423
I73 Other peripheral vascular diseases
0.000 0.577 0.423
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.578 0.422
I05.1 Rheumatic mitral insufficiency
0.000 0.580 0.420
E65-E68 Obesity and other hyperalimentation
0.000 0.585 0.415
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.588 0.412
E22.8 Other hyperfunction of pituitary gland
0.000 0.588 0.412
I70.01 Atherosclerosis of aorta (with gangrene)
0.000 0.588 0.412
E73.9 Lactose intolerance, unspecified
0.000 0.593 0.406
I07 Rheumatic tricuspid valve diseases
0.000 0.594 0.406
L41.9 Parapsoriasis, unspecified
0.000 0.595 0.405
L41.8 Other parapsoriasis
0.000 0.595 0.405
L41.5 Retiform parapsoriasis
0.000 0.595 0.405
L41.4 Large plaque parapsoriasis
0.000 0.595 0.405
L41.3 Small plaque parapsoriasis
0.000 0.595 0.405
L41.2 Lymphomatoid papulosis
0.000 0.595 0.405
L41.1 Pityriasis lichenoides chronica
0.000 0.595 0.405
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.595 0.405
L44.9 Papulosquamous disorder, unspecified
0.000 0.595 0.405
L44.8 Other specified papulosquamous disorders
0.000 0.595 0.405
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.595 0.405
L44.3 Lichen ruber moniliformis
0.000 0.595 0.405
L44.2 Lichen striatus
0.000 0.595 0.405
L44.1 Lichen nitidus
0.000 0.595 0.405
L44.0 Pityriasis rubra pilaris
0.000 0.595 0.405
E29.9 Testicular dysfunction, unspecified
0.000 0.596 0.404
E29.8 Other testicular dysfunction
0.000 0.596 0.404
E29.0 Testicular hyperfunction
0.000 0.596 0.404
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.597 0.402
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.600 0.400
K90 Intestinal malabsorption
0.000 0.603 0.397
E22.1 Hyperprolactinaemia
0.000 0.603 0.396
I08.0 Disorders of both mitral and aortic valves
0.000 0.604 0.396
I05.8 Other mitral valve diseases
0.000 0.604 0.396
I70.1 Atherosclerosis of renal artery
0.000 0.607 0.393
E26.9 Hyperaldosteronism, unspecified
0.000 0.612 0.388
E26.8 Other hyperaldosteronism
0.000 0.612 0.388
E26.1 Secondary hyperaldosteronism
0.000 0.612 0.388
I78 Diseases of capillaries
0.000 0.615 0.385
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.616 0.384
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.616 0.384
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.616 0.384
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.616 0.384
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.621 0.379
E80.5 Crigler-Najjar syndrome
0.000 0.621 0.379
E80.3 Defects of catalase and peroxydase
0.000 0.621 0.379
E80.2 Other porphyria
0.000 0.621 0.379
E80.0 Hereditary erythropoietic porphyria
0.000 0.621 0.379
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.621 0.379
I79.1 Aortitis in diseases classified elsewhere
0.000 0.621 0.379
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.000 0.621 0.379
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.000 0.622 0.378
E20.8 Other hypoparathyroidism
0.000 0.623 0.377
E20.1 Pseudohypoparathyroidism
0.000 0.623 0.377
E20.0 Idiopathic hypoparathyroidism
0.000 0.623 0.377
I05.9 Mitral valve disease, unspecified
0.000 0.625 0.375
E88.9 Metabolic disorder, unspecified
0.000 0.626 0.374
E88.8 Other specified metabolic disorders
0.000 0.626 0.374
I09.9 Rheumatic heart disease, unspecified
0.000 0.631 0.369
I74.0 Embolism and thrombosis of abdominal aorta
0.000 0.631 0.368
I02 Rheumatic chorea
0.000 0.632 0.367

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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