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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs16849225
log Bayes Factor = 9.82345
Chromosome 2   position 164,906,820  (GRCh37) Explore rs16849225 on Ensembl!
Variant rs16849225 is listed in the   GWAS Catalog   ⇪
Variant rs16849225 is part of Cluster X0228

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
I25.1 Atherosclerotic heart disease
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
I24 Other acute ischaemic heart diseases
0.000 0.001 0.999
I20 Angina pectoris
0.000 0.001 0.999
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.010 0.990
I20.9 Angina pectoris, unspecified
0.000 0.012 0.988
I25.5 Ischaemic cardiomyopathy
0.000 0.017 0.983
I22 Subsequent myocardial infarction
0.000 0.019 0.981
I20.0 Unstable angina
0.000 0.022 0.978
I24.8 Other forms of acute ischaemic heart disease
0.000 0.030 0.970
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.070 0.930
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.100 0.900
I20.8 Other forms of angina pectoris
0.000 0.108 0.892
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.115 0.885
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.164 0.836
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.173 0.827
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.195 0.805
I24.1 Dressler's syndrome
0.000 0.199 0.801
I23 Certain current complications following acute myocardial infarction
0.000 0.210 0.790
I22.8 Subsequent myocardial infarction of other sites
0.000 0.238 0.762
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
I25.4 Coronary artery aneurysm
0.000 0.344 0.656
I23.8 Other current complications following acute myocardial infarction
0.000 0.360 0.640
I25.2 Old myocardial infarction
0.000 0.429 0.571
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.433 0.567
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.433 0.567
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.433 0.567
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.433 0.567
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.433 0.567
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.433 0.567
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.433 0.567
I20.1 Angina pectoris with documented spasm
0.000 0.479 0.520
I21 Acute myocardial infarction
0.000 0.481 0.519
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.483 0.517
I21.9 Acute myocardial infarction, unspecified
0.000 0.531 0.469
I25.3 Aneurysm of heart
0.000 0.549 0.450
I21.4 Acute subendocardial myocardial infarction
0.000 0.551 0.449
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.625 0.375
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.628 0.372
G90-G99 Other disorders of the nervous system
0.295 0.705 0.000
G99 Other disorders of nervous system in diseases classified elsewhere
0.285 0.715 0.000
G99.2 Myelopathy in diseases classified elsewhere
0.282 0.718 0.000
G95 Other diseases of spinal cord
0.282 0.718 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.278 0.722 0.000
Chapter VI Diseases of the nervous system
0.278 0.722 0.000
G93 Other disorders of brain
0.271 0.729 0.000
G80 Infantile cerebral palsy
0.269 0.731 0.000
G95.8 Other specified diseases of spinal cord
0.267 0.733 0.000
G81 Hemiplegia
0.262 0.738 0.000
G93.6 Cerebral oedema
0.259 0.741 0.000
G95.2 Cord compression, unspecified
0.258 0.742 0.000
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.744 0.256
G20-G26 Extrapyramidal and movement disorders
0.253 0.747 0.000
G30-G32 Other degenerative diseases of the nervous system
0.245 0.755 0.000
G24 Dystonia
0.241 0.759 0.000
G94 Other disorders of brain in diseases classified elsewhere
0.239 0.761 0.000
G81.9 Hemiplegia, unspecified
0.238 0.762 0.000
G93.8 Other specified disorders of brain
0.238 0.762 0.000
G80.9 Infantile cerebral palsy, unspecified
0.238 0.762 0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.232 0.768 0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.230 0.770 0.000
G80.8 Other infantile cerebral palsy
0.230 0.770 0.000
G93.2 Benign intracranial hypertension
0.229 0.771 0.000
G98 Other disorders of nervous system, not elsewhere classified
0.226 0.774 0.000
G81.1 Spastic hemiplegia
0.225 0.775 0.000
G31.8 Other specified degenerative diseases of nervous system
0.222 0.778 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.222 0.778 0.000
G95.0 Syringomyelia and syringobulbia
0.217 0.783 0.000
G80.0 Spastic cerebral palsy
0.217 0.783 0.000
G80.2 Infantile hemiplegia
0.214 0.786 0.000
G24.9 Dystonia, unspecified
0.213 0.787 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.212 0.788 0.000
G92 Toxic encephalopathy
0.211 0.788 0.000
G24.3 Spasmodic torticollis
0.211 0.789 0.000
G97.0 Cerebrospinal fluid leak from spinal puncture
0.209 0.790 0.000
G93.0 Cerebral cysts
0.209 0.791 0.000
G93.5 Compression of brain
0.207 0.793 0.000
G80.1 Spastic diplegia
0.206 0.794 0.000
G94.2 Hydrocephalus in other diseases classified elsewhere
0.206 0.794 0.000
G23 Other degenerative diseases of basal ganglia
0.206 0.794 0.000
G96 Other disorders of central nervous system
0.205 0.795 0.000
G99.8 Other specified disorders of nervous system in diseases classified elsewhere
0.205 0.795 0.000
G99.1 Other disorders of autonomic nervous system in other diseases classified elsewhere
0.205 0.795 0.000
G83 Other paralytic syndromes
0.200 0.800 0.000
G95.1 Vascular myelopathies
0.199 0.801 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.197 0.803 0.000
G31.2 Degeneration of nervous system due to alcohol
0.196 0.804 0.000
G93.7 Reye's syndrome
0.195 0.805 0.000
G80.4 Ataxic cerebral palsy
0.193 0.807 0.000
G80.3 Dyskinetic cerebral palsy
0.193 0.807 0.000
G24.5 Blepharospasm
0.192 0.808 0.000
G91 Hydrocephalus
0.190 0.810 0.000
G61 Inflammatory polyneuropathy
0.190 0.810 0.000
G81.0 Flaccid hemiplegia
0.188 0.812 0.000
G32 Other degenerative disorders of nervous system in diseases classified elsewhere
0.188 0.812 0.000
G82 Paraplegia and tetraplegia
0.187 0.813 0.000
G04 Encephalitis, myelitis and encephalomyelitis
0.187 0.813 0.000
G93.1 Anoxic brain damage, not elsewhere classified
0.184 0.816 0.000
G06 Intracranial and intraspinal abscess and granuloma
0.182 0.818 0.000
G21 Secondary Parkinsonism
0.182 0.818 0.000
G26 Extrapyramidal and movement disorders in diseases classified elsewhere
0.182 0.818 0.000
G22 Parkinsonism in diseases classified elsewhere
0.182 0.818 0.000
G99.0 Autonomic neuropathy in endocrine and metabolic diseases
0.179 0.821 0.000
G70-G73 Diseases of myoneural junction and muscle
0.176 0.824 0.000
G83.8 Other specified paralytic syndromes
0.176 0.824 0.000
G24.8 Other dystonia
0.175 0.825 0.000
G93.4 Encephalopathy, unspecified
0.175 0.825 0.000
G24.4 Idiopathic orofacial dystonia
0.173 0.827 0.000
G24.2 Idiopathic nonfamilial dystonia
0.173 0.827 0.000
G24.1 Idiopathic familial dystonia
0.173 0.827 0.000
G24.0 Drug-induced dystonia
0.173 0.827 0.000
G94.8 Other specified disorders of brain in diseases classified elsewhere
0.172 0.828 0.000
G94.0 Hydrocephalus in infectious and parasitic diseases classified elsewhere
0.172 0.828 0.000
G02 Meningitis in other infectious and parasitic diseases classified elsewhere
0.170 0.830 0.000
G61.0 Guillain-Barre syndrome
0.169 0.831 0.000
G00 Bacterial meningitis, not elsewhere classified
0.168 0.832 0.000
G97.9 Postprocedural disorder of nervous system, unspecified
0.166 0.833 0.000
G97.2 Intracranial hypotension following ventricular shunting
0.166 0.833 0.000
G23.8 Other specified degenerative diseases of basal ganglia
0.165 0.834 0.000
G31.1 Senile degeneration of brain, not elsewhere classified
0.165 0.835 0.000
G64 Other disorders of peripheral nervous system
0.163 0.837 0.000
G08 Intracranial and intraspinal phlebitis and thrombophlebitis
0.163 0.837 0.000
G82.5 Tetraplegia, unspecified
0.162 0.838 0.000
G60 Hereditary and idiopathic neuropathy
0.161 0.839 0.000
G04.9 Encephalitis, myelitis and encephalomyelitis, unspecified
0.160 0.840 0.000
G07 Intracranial and intraspinal abscess and granuloma in diseases classified elsewhere
0.159 0.841 0.000
G94.1 Hydrocephalus in neoplastic disease
0.159 0.841 0.000
G20 Parkinson's disease
0.158 0.842 0.000
G31.0 Circumscribed brain atrophy
0.157 0.843 0.000
G23.1 Progressive supranuclear ophthalmoplegia [Steele-Richardson-Olszewski]
0.156 0.844 0.000
G06.1 Intraspinal abscess and granuloma
0.155 0.845 0.000
G83.2 Monoplegia of upper limb
0.154 0.846 0.000
G14 Postpolio syndrome
0.154 0.846 0.000
G61.9 Inflammatory polyneuropathy, unspecified
0.154 0.846 0.000
G90 Disorders of autonomic nervous system
0.153 0.847 0.000
G96.1 Disorders of meninges, not elsewhere classified
0.153 0.847 0.000
G97.1 Other reaction to spinal and lumbar puncture
0.153 0.847 0.000
G40-G47 Episodic and paroxysmal disorders
0.149 0.851 0.000
G96.8 Other specified disorders of central nervous system
0.149 0.851 0.000
G91.8 Other hydrocephalus
0.149 0.851 0.000
G23.9 Degenerative disease of basal ganglia, unspecified
0.147 0.852 0.000
G23.3 Multiple system atrophy, cerebellar type
0.147 0.852 0.000
G23.2 Striatonigral degeneration
0.147 0.852 0.000
G23.0 Hallervorden-Spatz disease
0.147 0.852 0.000
G96.9 Disorder of central nervous system, unspecified
0.147 0.852 0.000
G32.8 Other specified degenerative disorders of nervous system in diseases classified elsewhere
0.147 0.853 0.000
G12 Spinal muscular atrophy and related syndromes
0.147 0.853 0.000
G05 Encephalitis, myelitis and encephalomyelitis in diseases classified elsewhere
0.147 0.853 0.000
G91.0 Communicating hydrocephalus
0.145 0.855 0.000
G83.5 Locked-in syndrome
0.144 0.856 0.000
G83.3 Monoplegia, unspecified
0.144 0.856 0.000
G83.0 Diplegia of upper limbs
0.144 0.856 0.000
G25 Other extrapyramidal and movement disorders
0.142 0.858 0.000
G13 Systemic atrophies primarily affecting central nervous system in diseases classified elsewhere
0.141 0.858 0.000
G00.9 Bacterial meningitis, unspecified
0.141 0.859 0.000
G09 Sequelae of inflammatory diseases of central nervous system
0.141 0.859 0.000
G03 Meningitis due to other and unspecified causes
0.140 0.859 0.000
G04.8 Other encephalitis, myelitis and encephalomyelitis
0.139 0.861 0.000
G01 Meningitis in bacterial diseases classified elsewhere
0.137 0.863 0.000
G82.1 Spastic paraplegia
0.137 0.863 0.000
G83.4 Cauda equina syndrome
0.137 0.863 0.000
G91.3 Posttraumatic hydrocephalus, unspecified
0.137 0.863 0.000
G61.1 Serum neuropathy
0.137 0.863 0.000
G44 Other headache syndromes
0.136 0.864 0.000
G60.8 Other hereditary and idiopathic neuropathies
0.135 0.865 0.000
G32.0 Subacute combined degeneration of spinal cord in diseases classified elsewhere
0.135 0.865 0.000
G72 Other myopathies
0.135 0.865 0.000
G83.9 Paralytic syndrome, unspecified
0.135 0.865 0.000
G82.3 Flaccid tetraplegia
0.134 0.866 0.000
G82.0 Flaccid paraplegia
0.134 0.866 0.000
G04.2 Bacterial meningoencephalitis and meningomyelitis, not elsewhere classified
0.134 0.866 0.000
G04.1 Tropical spastic paraplegia
0.134 0.866 0.000
G04.0 Acute disseminated encephalitis
0.134 0.866 0.000
G61.8 Other inflammatory polyneuropathies
0.134 0.866 0.000
G02.0 Meningitis in viral diseases classified elsewhere
0.133 0.867 0.000
G91.2 Normal-pressure hydrocephalus
0.133 0.867 0.000
G96.0 Cerebrospinal fluid leak
0.133 0.867 0.000
G10 Huntington's disease
0.132 0.868 0.000
G45 Transient cerebral ischaemic attacks and related syndromes
0.131 0.869 0.000
G21.9 Secondary Parkinsonism, unspecified
0.130 0.869 0.000
G21.8 Other secondary Parkinsonism
0.130 0.869 0.000
G21.4 Vascular parkinsonism
0.130 0.869 0.000
G21.3 Postencephalitic Parkinsonism
0.130 0.869 0.000
G21.2 Secondary Parkinsonism due to other external agents
0.130 0.869 0.000
G21.1 Other drug-induced secondary Parkinsonism
0.130 0.869 0.000
G21.0 Malignant neuroleptic syndrome
0.130 0.869 0.000
G91.1 Obstructive hydrocephalus
0.130 0.870 0.000
G06.2 Extradural and subdural abscess, unspecified
0.130 0.870 0.000
G06.0 Intracranial abscess and granuloma
0.129 0.871 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.128 0.872 0.000
G90.8 Other disorders of autonomic nervous system
0.127 0.873 0.000
G82.4 Spastic tetraplegia
0.127 0.873 0.000
G11 Hereditary ataxia
0.127 0.873 0.000
G73 Disorders of myoneural junction and muscle in diseases classified elsewhere
0.126 0.874 0.000
I10 Essential (primary) hypertension
0.000 0.874 0.126
G97.8 Other postprocedural disorders of nervous system
0.125 0.875 0.000
Z95.1 Presence of aortocoronary bypass graft
0.000 0.876 0.124
G93.3 Postviral fatigue syndrome
0.123 0.877 0.000
G02.8 Meningitis in other specified infectious and parasitic diseases classified elsewhere
0.122 0.878 0.000
G02.1 Meningitis in mycoses
0.122 0.878 0.000
G70 Myasthenia gravis and other myoneural disorders
0.121 0.879 0.000
G00.8 Other bacterial meningitis
0.121 0.879 0.000
G00.3 Staphylococcal meningitis
0.121 0.879 0.000
G00.2 Streptococcal meningitis
0.121 0.879 0.000
G00.0 Haemophilus meningitis
0.121 0.879 0.000
G60.9 Hereditary and idiopathic neuropathy, unspecified
0.120 0.880 0.000
G44.0 Cluster headache syndrome
0.118 0.882 0.000
G45.3 Amaurosis fugax
0.118 0.882 0.000
G30 Alzheimer's disease
0.117 0.883 0.000
G90.0 Idiopathic peripheral autonomic neuropathy
0.117 0.883 0.000
G60.3 Idiopathic progressive neuropathy
0.116 0.884 0.000
G60.2 Neuropathy in association with hereditary ataxia
0.116 0.884 0.000
G60.1 Refsum's disease
0.116 0.884 0.000
G25.2 Other specified forms of tremor
0.114 0.886 0.000
G72.1 Alcoholic myopathy
0.112 0.888 0.000
G44.2 Tension-type headache
0.112 0.888 0.000
G45.4 Transient global amnesia
0.111 0.889 0.000
G12.2 Motor neuron disease
0.111 0.889 0.000
G90.4 Autonomic dysreflexia
0.110 0.890 0.000
G90.1 Familial dysautonomia [Riley-Day]
0.110 0.890 0.000
G45.8 Other transient cerebral ischaemic attacks and related syndromes
0.108 0.892 0.000
G72.0 Drug-induced myopathy
0.108 0.892 0.000
G46 Vascular syndromes of brain in cerebrovascular diseases
0.108 0.892 0.000
G12.9 Spinal muscular atrophy, unspecified
0.105 0.894 0.000
G12.8 Other spinal muscular atrophies and related syndromes
0.105 0.894 0.000
G12.1 Other inherited spinal muscular atrophy
0.105 0.894 0.000
G12.0 Infantile spinal muscular atrophy, type I [Werdnig-Hoffman]
0.105 0.894 0.000
G05.8 Encephalitis, myelitis and encephalomyelitis in other diseases classified elsewhere
0.105 0.895 0.000
G05.2 Encephalitis, myelitis and encephalomyelitis in other infectious and parasitic diseases classified elsewhere
0.105 0.895 0.000
G05.0 Encephalitis, myelitis and encephalomyelitis in bacterial diseases classified elsewhere
0.105 0.895 0.000
G25.1 Drug-induced tremor
0.105 0.895 0.000
G25.9 Extrapyramidal and movement disorder, unspecified
0.105 0.895 0.000
G25.3 Myoclonus
0.104 0.895 0.000
G44.3 Chronic posttraumatic headache
0.103 0.897 0.000
G25.6 Drug-induced tics and other tics of organic origin
0.102 0.898 0.000
G25.5 Other chorea
0.102 0.898 0.000
G25.4 Drug-induced chorea
0.102 0.898 0.000
G13.8 Systemic atrophy primarily affecting central nervous system in other diseases classified elsewhere
0.102 0.898 0.000
G13.2 Systemic atrophy primarily affecting central nervous system in myxoedema
0.102 0.898 0.000
G13.1 Other systemic atrophy primarily affecting central nervous system in neoplastic disease
0.102 0.898 0.000
G13.0 Paraneoplastic neuromyopathy and neuropathy
0.102 0.898 0.000
G03.8 Meningitis due to other specified causes
0.101 0.899 0.000
G03.2 Benign recurrent meningitis [Mollaret]
0.101 0.899 0.000
G03.1 Chronic meningitis
0.101 0.899 0.000
G03.0 Nonpyogenic meningitis
0.101 0.899 0.000
G00.1 Pneumococcal meningitis
0.100 0.899 0.000
G47 Sleep disorders
0.101 0.899 0.000
G90.3 Multisystem degeneration
0.100 0.900 0.000
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.900 0.100
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.900 0.100
G72.4 Inflammatory myopathy, not elsewhere classified
0.098 0.902 0.000
G44.1 Vascular headache, not elsewhere classified
0.097 0.903 0.000
G71 Primary disorders of muscles
0.097 0.903 0.000
G72.3 Periodic paralysis
0.097 0.903 0.000
G72.2 Myopathy due to other toxic agents
0.097 0.903 0.000
G44.4 Drug-induced headache, not elsewhere classified
0.096 0.904 0.000
G31.9 Degenerative disease of nervous system, unspecified
0.095 0.905 0.000
G44.8 Other specified headache syndromes
0.095 0.905 0.000
G72.8 Other specified myopathies
0.094 0.906 0.000
G45.2 Multiple and bilateral precerebral artery syndromes
0.094 0.906 0.000
G45.1 Carotid artery syndrome (hemispheric)
0.094 0.906 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.094 0.906 0.000
G11.4 Hereditary spastic paraplegia
0.094 0.906 0.000
G91.9 Hydrocephalus, unspecified
0.094 0.906 0.000
G05.1 Encephalitis, myelitis and encephalomyelitis in viral diseases classified elsewhere
0.093 0.907 0.000
G60.0 Hereditary motor and sensory neuropathy
0.092 0.908 0.000
G63.8 Polyneuropathy in other diseases classified elsewhere
0.092 0.908 0.000
G63.6 Polyneuropathy in other musculoskeletal disorders
0.092 0.908 0.000
G63.5 Polyneuropathy in systemic connective tissue disorders
0.092 0.908 0.000
G63.4 Polyneuropathy in nutritional deficiency
0.092 0.908 0.000
G63.3 Polyneuropathy in other endocrine and metabolic diseases
0.092 0.908 0.000
G63.1 Polyneuropathy in neoplastic disease
0.092 0.908 0.000
G63.0 Polyneuropathy in infectious and parasitic diseases classified elsewhere
0.092 0.908 0.000
G11.8 Other hereditary ataxias
0.091 0.909 0.000
G11.3 Cerebellar ataxia with defective DNA repair
0.091 0.909 0.000
G11.2 Late-onset cerebellar ataxia
0.091 0.909 0.000
G11.1 Early-onset cerebellar ataxia
0.091 0.909 0.000
G11.0 Congenital nonprogressive ataxia
0.091 0.909 0.000
G73.7 Myopathy other diseases classified elsewhere
0.091 0.909 0.000
G73.6 Myopathy in metabolic diseases
0.091 0.909 0.000
G73.5 Myopathy in endocrine diseases
0.091 0.909 0.000
G73.4 Myopathy in infectious and parasitic diseases classified elsewhere
0.091 0.909 0.000
G73.3 Myasthenic syndromes in other diseases classified elsewhere
0.091 0.909 0.000
G73.2 Other myasthenic syndromes in neoplastic disease
0.091 0.909 0.000
G73.1 Eaton-Lambert syndrome
0.091 0.909 0.000
G73.0 Myasthenic syndromes in endocrine diseases
0.091 0.909 0.000
G30.1 Alzheimer's disease with late onset
0.089 0.911 0.000
G45.0 Vertebro-basilar artery syndrome
0.087 0.913 0.000
G70.8 Other specified myoneural disorders
0.087 0.913 0.000
G70.2 Congenital and developmental myasthenia
0.087 0.913 0.000
G70.1 Toxic myoneural disorders
0.087 0.913 0.000
G47.3 Sleep apnoea
0.087 0.913 0.000
G41 Status epilepticus
0.086 0.913 0.000
G25.8 Other specified extrapyramidal and movement disorders
0.086 0.914 0.000
G70.0 Myasthenia gravis
0.086 0.914 0.000
G55.3 Nerve root and plexus compressions in other dorsopathies
0.085 0.915 0.000
G30.0 Alzheimer's disease with early onset
0.084 0.915 0.000
G95.9 Disease of spinal cord, unspecified
0.084 0.916 0.001
G70.9 Myoneural disorder, unspecified
0.083 0.917 0.000
G83.1 Monoplegia of lower limb
0.082 0.918 0.001
G03.9 Meningitis, unspecified
0.082 0.918 0.000
G46.7 Other lacunar syndromes
0.081 0.918 0.000
G58 Other mononeuropathies
0.082 0.918 0.000
G51 Facial nerve disorders
0.079 0.921 0.000
G55 Nerve root and plexus compressions in diseases classified elsewhere
0.079 0.921 0.000
G47.0 Disorders of initiating and maintaining sleep [insomnias]
0.078 0.921 0.000
G58.8 Other specified mononeuropathies
0.078 0.922 0.000
G47.8 Other sleep disorders
0.078 0.922 0.000
G46.8 Other vascular syndromes of brain in cerebrovascular diseases
0.077 0.922 0.000
G46.6 Pure sensory lacunar syndrome
0.077 0.922 0.000
G46.5 Pure motor lacunar syndrome
0.077 0.922 0.000
G46.3 Brain stem stroke syndrome
0.077 0.922 0.000
G46.2 Posterior cerebral artery syndrome
0.077 0.922 0.000
G46.1 Anterior cerebral artery syndrome
0.077 0.922 0.000
G46.0 Middle cerebral artery syndrome
0.077 0.922 0.000
G30.8 Other Alzheimer's disease
0.076 0.923 0.000
Z95.5 Presence of coronary angioplasty implant and graft
0.000 0.924 0.076
G62 Other polyneuropathies
0.075 0.925 0.000
G46.4 Cerebellar stroke syndrome
0.074 0.926 0.000
Z95 Presence of cardiac and vascular implants and grafts
0.000 0.927 0.073
G90.2 Horner's syndrome
0.072 0.927 0.000
G47.2 Disorders of the sleep-wake schedule
0.072 0.928 0.000
G11.9 Hereditary ataxia, unspecified
0.072 0.928 0.000
G41.8 Other status epilepticus
0.071 0.929 0.000
G51.3 Clonic hemifacial spasm
0.071 0.929 0.000
G47.4 Narcolepsy and cataplexy
0.071 0.929 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.070 0.929 0.000
G71.3 Mitochondrial myopathy, not elsewhere classified
0.070 0.930 0.000
G71.9 Primary disorder of muscle, unspecified
0.070 0.930 0.000
G71.8 Other primary disorders of muscles
0.070 0.930 0.000
G71.2 Congenital myopathies
0.070 0.930 0.000
G63.2 Diabetic polyneuropathy
0.068 0.932 0.000
G52 Disorders of other cranial nerves
0.066 0.934 0.000
G51.9 Disorder of facial nerve, unspecified
0.066 0.934 0.000
G72.9 Myopathy, unspecified
0.065 0.934 0.000
Z82.4 Family history of ischaemic heart disease and other diseases of the circulatory system
0.000 0.936 0.064
G90.9 Disorder of autonomic nervous system, unspecified
0.063 0.937 0.001
G41.2 Complex partial status epilepticus
0.062 0.938 0.000
G41.1 Petit mal status epilepticus
0.062 0.938 0.000
Z95.9 Presence of cardiac and vascular implant and graft, unspecified
0.000 0.938 0.062
G62.0 Drug-induced polyneuropathy
0.062 0.938 0.000
Z95.8 Presence of other cardiac and vascular implants and grafts
0.000 0.938 0.062
G82.2 Paraplegia, unspecified
0.061 0.938 0.000
G50 Disorders of trigeminal nerve
0.060 0.940 0.000
G53 Cranial nerve disorders in diseases classified elsewhere
0.060 0.940 0.000
G51.8 Other disorders of facial nerve
0.059 0.941 0.000
G58.0 Intercostal neuropathy
0.059 0.941 0.000
G71.0 Muscular dystrophy
0.058 0.942 0.000
G59 Mononeuropathy in diseases classified elsewhere
0.058 0.942 0.000
G51.4 Facial myokymia
0.057 0.943 0.000
G51.2 Melkersson's syndrome
0.057 0.943 0.000
G51.1 Geniculate ganglionitis
0.057 0.943 0.000
G71.1 Myotonic disorders
0.057 0.943 0.000
G93.9 Disorder of brain, unspecified
0.055 0.944 0.001
G62.2 Polyneuropathy due to other toxic agents
0.054 0.946 0.000
G62.1 Alcoholic polyneuropathy
0.053 0.947 0.000
G52.8 Disorders of other specified cranial nerves
0.052 0.947 0.000
G36 Other acute disseminated demyelination
0.050 0.949 0.000
G58.9 Mononeuropathy, unspecified
0.050 0.950 0.000
G47.1 Disorders of excessive somnolence [hypersomnias]
0.049 0.951 0.000
G52.7 Disorders of multiple cranial nerves
0.047 0.952 0.000
G52.2 Disorders of vagus nerve
0.047 0.952 0.000
G52.1 Disorders of glossopharyngeal nerve
0.047 0.952 0.000
G52.0 Disorders of olfactory nerve
0.047 0.952 0.000
G55.0 Nerve root and plexus compressions in neoplastic disease
0.047 0.953 0.000
G41.0 Grand mal status epilepticus
0.045 0.954 0.000
G52.3 Disorders of hypoglossal nerve
0.045 0.955 0.000
G41.9 Status epilepticus, unspecified
0.044 0.955 0.000
G58.7 Mononeuritis multiplex
0.044 0.955 0.000
G50.9 Disorder of trigeminal nerve, unspecified
0.043 0.957 0.000
G50.8 Other disorders of trigeminal nerve
0.043 0.957 0.000
G53.8 Other cranial nerve disorders in other diseases classified elsewhere
0.043 0.957 0.000
G53.3 Multiple cranial nerve palsies in neoplastic disease
0.043 0.957 0.000
G53.2 Multiple cranial nerve palsies in sarcoidosis
0.043 0.957 0.000
G53.1 Multiple cranial nerve palsies in infectious and parasitic diseases classified elsewhere
0.043 0.957 0.000
G50.0 Trigeminal neuralgia
0.043 0.957 0.000
G47.9 Sleep disorder, unspecified
0.043 0.957 0.000
Z95.0 Presence of cardiac pacemaker
0.000 0.957 0.043
G59.8 Other mononeuropathies in diseases classified elsewhere
0.042 0.958 0.000
G52.9 Cranial nerve disorder, unspecified
0.041 0.959 0.000
I10-I15 Hypertensive diseases
0.000 0.960 0.040
G55.8 Nerve root and plexus compressions in other diseases classified elsewhere
0.039 0.961 0.000
G45.9 Transient cerebral ischaemic attack, unspecified
0.037 0.963 0.000
G36.9 Acute disseminated demyelination, unspecified
0.036 0.963 0.000
G36.8 Other specified acute disseminated demyelination
0.036 0.963 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.036 0.963 0.000
G25.0 Essential tremor
0.036 0.963 0.001
G36.0 Neuromyelitis optica [Devic]
0.036 0.963 0.000
G50.1 Atypical facial pain
0.036 0.964 0.000
G53.0 Postzoster neuralgia
0.035 0.964 0.000
G56 Mononeuropathies of upper limb
0.034 0.966 0.000
G51.0 Bell's palsy
0.034 0.966 0.000
G43 Migraine
0.032 0.968 0.000
G59.0 Diabetic mononeuropathy
0.032 0.968 0.000
G54 Nerve root and plexus disorders
0.031 0.969 0.000
G30.9 Alzheimer's disease, unspecified
0.031 0.969 0.000
I13 Hypertensive heart and renal disease
0.000 0.971 0.028
G56.1 Other lesions of median nerve
0.028 0.972 0.000
G57 Mononeuropathies of lower limb
0.027 0.973 0.000
G37 Other demyelinating diseases of central nervous system
0.025 0.974 0.001
Z95.3 Presence of xenogenic heart valve
0.000 0.974 0.026
G56.4 Causalgia
0.025 0.975 0.000
Chapter IX Diseases of the circulatory system
0.000 0.975 0.025
G43.0 Migraine without aura [common migraine]
0.025 0.975 0.000
G56.9 Mononeuropathy of upper limb, unspecified
0.025 0.975 0.000
G43.3 Complicated migraine
0.025 0.975 0.000
G57.5 Tarsal tunnel syndrome
0.024 0.976 0.000
G56.8 Other mononeuropathies of upper limb
0.023 0.977 0.000
G43.2 Status migrainosus
0.023 0.977 0.000
G54.2 Cervical root disorders, not elsewhere classified
0.023 0.977 0.000
G54.4 Lumbosacral root disorders, not elsewhere classified
0.023 0.977 0.000
I15 Secondary hypertension
0.000 0.977 0.023
G54.7 Phantom limb syndrome without pain
0.022 0.977 0.000
G54.5 Neuralgic amyotrophy
0.022 0.977 0.000
G54.3 Thoracic root disorders, not elsewhere classified
0.022 0.977 0.000
G54.1 Lumbosacral plexus disorders
0.022 0.977 0.000
G56.3 Lesion of radial nerve
0.023 0.977 0.000
I11 Hypertensive heart disease
0.000 0.979 0.021
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.979 0.021
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.979 0.021
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.979 0.021
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.979 0.021
G37.8 Other specified demyelinating diseases of central nervous system
0.019 0.980 0.001
I12 Hypertensive renal disease
0.000 0.980 0.020
G57.0 Lesion of sciatic nerve
0.020 0.980 0.000
G57.4 Lesion of medial popliteal nerve
0.020 0.980 0.000
G57.2 Lesion of femoral nerve
0.020 0.980 0.000
G54.6 Phantom limb syndrome with pain
0.019 0.980 0.000
G54.0 Brachial plexus disorders
0.019 0.980 0.000
G40 Epilepsy
0.019 0.981 0.000
G54.8 Other nerve root and plexus disorders
0.019 0.981 0.000
G55.2 Nerve root and plexus compressions in spondylosis
0.019 0.981 0.000
G62.8 Other specified polyneuropathies
0.019 0.981 0.001
G37.5 Concentric sclerosis [Balo]
0.018 0.981 0.001
G37.4 Subacute necrotising myelitis
0.018 0.981 0.001
G37.2 Central pontine myelinolysis
0.018 0.981 0.001
G37.1 Central demyelination of corpus callosum
0.018 0.981 0.001
G37.0 Diffuse sclerosis
0.018 0.981 0.001
G57.1 Meralgia paraesthetica
0.019 0.981 0.000
Z82 Family history of certain disabilities and chronic diseases leading to disablement
0.000 0.982 0.018
Z95.2 Presence of prosthetic heart valve
0.000 0.982 0.018
G55.1 Nerve root and plexus compressions in intervertebral disk disorders
0.018 0.982 0.000
G56.2 Lesion of ulnar nerve
0.018 0.982 0.000
I00-I02 Acute rheumatic fever
0.000 0.983 0.017
G57.3 Lesion of lateral popliteal nerve
0.017 0.983 0.000
G57.9 Mononeuropathy of lower limb, unspecified
0.017 0.983 0.000
I15.0 Renovascular hypertension
0.000 0.983 0.017
I15.8 Other secondary hypertension
0.000 0.983 0.016
I15.2 Hypertension secondary to endocrine disorders
0.000 0.983 0.016
G62.9 Polyneuropathy, unspecified
0.017 0.983 0.000
G43.8 Other migraine
0.015 0.984 0.000
G40.1 Localisation-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
0.015 0.985 0.000
G40.3 Generalised idiopathic epilepsy and epileptic syndromes
0.015 0.985 0.000
G40.4 Other generalised epilepsy and epileptic syndromes
0.015 0.985 0.000
G40.0 Localisation-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localised onset
0.015 0.985 0.000
Z82.6 Family history of arthritis and other diseases of the musculoskeletal system and connective tissue
0.000 0.985 0.015
I15.9 Seconday hypertension, unspecified
0.000 0.985 0.014
I12.9 Hypertensive renal disease without renal failure
0.000 0.986 0.014
Z82.7 Family history of congenital malformations, deformations and chromosomal abnormalities
0.000 0.986 0.014
Z82.2 Family history of deafness and hearing loss
0.000 0.986 0.014
I15.1 Hypertension secondary to other renal disorders
0.000 0.986 0.013
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.986 0.013
G40.5 Special epileptic syndromes
0.014 0.986 0.000
Z82.8 Family history of other disabilities and chronic diseases leading to disablement, not elsewhere classified
0.000 0.987 0.013
I02 Rheumatic chorea
0.000 0.987 0.012
I01 Rheumatic fever with heart involvement
0.000 0.987 0.012
N88.2 Stricture and stenosis of cervix uteri
0.013 0.987 0.000
Z82.0 Family history of epilepsy and other diseases of the nervous system
0.000 0.987 0.013
G54.9 Nerve root and plexus disorder, unspecified
0.012 0.987 0.000
I05-I09 Chronic rheumatic heart diseases
0.000 0.988 0.012
Z82.5 Family history of asthma and other chronic lower respiratory diseases
0.000 0.988 0.012
G40.6 Grand mal seizures, unspecified (with or without petit mal)
0.012 0.988 0.000
G43.1 Migraine with aura [classical migraine]
0.012 0.988 0.000
I00 Rheumatic fever without mention of heart involvement
0.000 0.988 0.012
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.989 0.011
R25.2 Cramp and spasm
0.011 0.989 0.000
G57.8 Other mononeuropathies of lower limb
0.011 0.989 0.000
I47.2 Ventricular tachycardia
0.000 0.989 0.011
Z82.1 Family history of blindness and visual loss
0.000 0.989 0.010
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.009 0.989 0.002
G40.7 Petit mal, unspecified, without grand mal seizures
0.010 0.990 0.000
I01.9 Acute rheumatic heart disease, unspecified
0.000 0.991 0.009
I01.8 Other acute rheumatic heart disease
0.000 0.991 0.009
I01.2 Acute rheumatic myocarditis
0.000 0.991 0.009
I01.1 Acute rheumatic endocarditis
0.000 0.991 0.009
I01.0 Acute rheumatic pericarditis
0.000 0.991 0.009
I02.9 Rheumatic chorea without heart involvement
0.000 0.991 0.009
I02.0 Rheumatic chorea with heart involvement
0.000 0.991 0.009
I09 Other rheumatic heart diseases
0.000 0.991 0.009
I06 Rheumatic aortic valve diseases
0.000 0.991 0.009
I08 Multiple valve diseases
0.000 0.991 0.009
G40.2 Localisation-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
0.008 0.991 0.000
R25.3 Fasciculation
0.008 0.992 0.000
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.000 0.992 0.008
R25 Abnormal involuntary movements
0.008 0.992 0.000
Z82.3 Family history of stroke
0.000 0.992 0.008
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.000 0.992 0.008
G37.9 Demyelinating disease of central nervous system, unspecified
0.006 0.992 0.002
I05 Rheumatic mitral valve diseases
0.000 0.992 0.008

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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