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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs17162040
log Bayes Factor = 6.74453
Chromosome 1   position 27,883,227  (GRCh37) Explore rs17162040 on Ensembl!
Variant rs17162040 is part of Cluster X0034

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
Chapter IX Diseases of the circulatory system
0.000 0.001 0.999
I25.1 Atherosclerotic heart disease
0.000 0.004 0.996
I30-I52 Other forms of heart disease
0.000 0.004 0.996
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.007 0.993
I21 Acute myocardial infarction
0.000 0.011 0.989
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.021 0.979
I73 Other peripheral vascular diseases
0.000 0.028 0.972
I05-I09 Chronic rheumatic heart diseases
0.000 0.028 0.972
I50 Heart failure
0.000 0.056 0.944
I73.0 Raynaud's syndrome
0.000 0.057 0.943
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.059 0.941
I47 Paroxysmal tachycardia
0.000 0.061 0.939
I08 Multiple valve diseases
0.000 0.068 0.932
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.069 0.931
I47.2 Ventricular tachycardia
0.000 0.080 0.920
I20 Angina pectoris
0.000 0.093 0.907
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.000 0.105 0.895
I72 Other aneurysm
0.000 0.105 0.895
I21.9 Acute myocardial infarction, unspecified
0.000 0.114 0.886
I05 Rheumatic mitral valve diseases
0.000 0.115 0.885
I20.0 Unstable angina
0.000 0.117 0.883
I44 Atrioventricular and left bundle-branch block
0.000 0.118 0.882
I24 Other acute ischaemic heart diseases
0.000 0.119 0.881
I08.0 Disorders of both mitral and aortic valves
0.000 0.122 0.878
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.122 0.878
I50.0 Congestive heart failure
0.000 0.141 0.859
I21.4 Acute subendocardial myocardial infarction
0.000 0.147 0.853
I46 Cardiac arrest
0.000 0.157 0.843
I77 Other disorders of arteries and arterioles
0.000 0.157 0.843
I24.8 Other forms of acute ischaemic heart disease
0.000 0.159 0.841
I25.2 Old myocardial infarction
0.000 0.160 0.840
I73.9 Peripheral vascular disease, unspecified
0.000 0.172 0.828
I25.5 Ischaemic cardiomyopathy
0.000 0.173 0.827
I45 Other conduction disorders
0.000 0.184 0.816
I22 Subsequent myocardial infarction
0.000 0.184 0.816
I25.3 Aneurysm of heart
0.000 0.189 0.811
I37 Pulmonary valve disorders
0.000 0.189 0.811
I77.1 Stricture of artery
0.000 0.189 0.811
I72.4 Aneurysm of artery of lower extremity
0.000 0.190 0.810
I50.1 Left ventricular failure
0.000 0.191 0.809
I74 Arterial embolism and thrombosis
0.000 0.192 0.808
I49 Other cardiac arrhythmias
0.000 0.214 0.786
I05.0 Mitral stenosis
0.000 0.215 0.785
E78.0 Pure hypercholesterolaemia
0.000 0.221 0.779
I70 Atherosclerosis
0.000 0.222 0.778
I51 Complications and ill-defined descriptions of heart disease
0.000 0.225 0.775
I46.0 Cardiac arrest with successful resuscitation
0.000 0.231 0.768
I34 Nonrheumatic mitral valve disorders
0.000 0.236 0.764
I44.0 Atrioventricular block, first degree
0.000 0.240 0.760
I31 Other diseases of pericardium
0.000 0.243 0.757
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.247 0.753
I42 Cardiomyopathy
0.000 0.254 0.746
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.266 0.734
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.269 0.731
I49.8 Other specified cardiac arrhythmias
0.000 0.270 0.730
I44.1 Atrioventricular block, second degree
0.000 0.279 0.721
I23 Certain current complications following acute myocardial infarction
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
I00-I02 Acute rheumatic fever
0.000 0.283 0.716
I10-I15 Hypertensive diseases
0.000 0.286 0.714
I52 Other heart disorders in diseases classified elsewhere
0.000 0.286 0.714
I48 Atrial fibrillation and flutter
0.000 0.286 0.714
I43 Cardiomyopathy in diseases classified elsewhere
0.000 0.286 0.714
I41 Myocarditis in diseases classified elsewhere
0.000 0.286 0.714
I40 Acute myocarditis
0.000 0.286 0.714
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.000 0.286 0.714
I32 Pericarditis in diseases classified elsewhere
0.000 0.286 0.714
I50.9 Heart failure, unspecified
0.000 0.286 0.714
I44.2 Atrioventricular block, complete
0.000 0.288 0.712
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.291 0.709
I72.0 Aneurysm of carotid artery
0.000 0.293 0.707
I73.8 Other specified peripheral vascular diseases
0.000 0.296 0.704
I49.3 Ventricular premature depolarisation
0.000 0.300 0.700
I73.1 Thromboangiitis obliterans [Buerger]
0.000 0.303 0.697
I09 Other rheumatic heart diseases
0.000 0.303 0.697
I06 Rheumatic aortic valve diseases
0.000 0.303 0.697
I36 Nonrheumatic tricuspid valve disorders
0.000 0.304 0.696
I95-I99 Other and unspecified disorders of the circulatory system
0.000 0.306 0.694
I42.0 Dilated cardiomyopathy
0.000 0.306 0.694
I30 Acute pericarditis
0.000 0.311 0.689
I05.1 Rheumatic mitral insufficiency
0.000 0.311 0.689
I44.6 Other and unspecified fascicular block
0.000 0.312 0.688
I05.9 Mitral valve disease, unspecified
0.000 0.314 0.686
I33 Acute and subacute endocarditis
0.000 0.315 0.685
I37.1 Pulmonary valve insufficiency
0.000 0.322 0.678
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.322 0.678
I25.4 Coronary artery aneurysm
0.000 0.324 0.676
I08.9 Multiple valve disease, unspecified
0.000 0.332 0.668
I08.2 Disorders of both aortic and tricuspid valves
0.000 0.332 0.668
I51.9 Heart disease, unspecified
0.000 0.332 0.668
I45.9 Conduction disorder, unspecified
0.000 0.336 0.663
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.000 0.345 0.655
I49.0 Ventricular fibrillation and flutter
0.000 0.345 0.655
I31.9 Disease of pericardium, unspecified
0.000 0.349 0.651
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.000 0.354 0.646
I72.9 Aneurysm of unspecified site
0.000 0.358 0.641
I72.6 Aneurysm and dissection of vertebral artery
0.000 0.358 0.641
I72.5 Aneurysm and dissection of other precerebral arteries
0.000 0.358 0.641
I72.2 Aneurysm of renal artery
0.000 0.358 0.641
I72.1 Aneurysm of artery of upper extremity
0.000 0.358 0.641
I05.8 Other mitral valve diseases
0.000 0.365 0.634
I05.2 Mitral stenosis with insufficiency
0.000 0.365 0.634
I44.5 Left posterior fascicular block
0.000 0.368 0.632
I44.4 Left anterior fascicular block
0.000 0.368 0.632
I24.1 Dressler's syndrome
0.000 0.368 0.631
I47.0 Reentry ventricular arrhythmia
0.000 0.370 0.630
I45.1 Other and unspecified right bundle-branch block
0.000 0.370 0.630
I20.9 Angina pectoris, unspecified
0.000 0.371 0.629
I72.3 Aneurysm of iliac artery
0.000 0.372 0.628
I72.8 Aneurysm of other specified arteries
0.000 0.374 0.626
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.375 0.625
I47.1 Supraventricular tachycardia
0.000 0.387 0.613
I45.5 Other specified heart block
0.000 0.389 0.611
I22.8 Subsequent myocardial infarction of other sites
0.000 0.390 0.609
I34.9 Nonrheumatic mitral valve disorder, unspecified
0.000 0.392 0.608
I98 Other disorders of circulatory system in diseases classified elsewhere
0.000 0.395 0.605
I46.1 Sudden cardiac death, so described
0.000 0.395 0.605
I45.3 Trifascicular block
0.000 0.395 0.605
I77.5 Necrosis of artery
0.000 0.396 0.604
I77.4 Coeliac artery compression syndrome
0.000 0.396 0.604
I77.3 Arterial fibromuscular dysplasia
0.000 0.396 0.604
I77.2 Rupture of artery
0.000 0.396 0.604
I74.5 Embolism and thrombosis of iliac artery
0.000 0.396 0.604
I51.8 Other ill-defined heart diseases
0.000 0.396 0.604
I08.8 Other multiple valve diseases
0.000 0.399 0.601
I74.8 Embolism and thrombosis of other arteries
0.000 0.401 0.599
I70.0 Atherosclerosis of aorta
0.000 0.401 0.599
I44.3 Other and unspecified atrioventricular block
0.000 0.402 0.598
I45.2 Bifascicular block
0.000 0.404 0.596
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.405 0.595
I70.2 Atherosclerosis of arteries of the extremities
0.000 0.412 0.588
I45.4 Nonspecific intraventricular block
0.000 0.414 0.585
I45.0 Right fascicular block
0.000 0.414 0.585
I37.9 Pulmonary valve disorder, unspecified
0.000 0.419 0.581
I37.8 Other pulmonary valve disorders
0.000 0.419 0.581
I37.2 Pulmonary valve stenosis with insufficiency
0.000 0.419 0.581
I37.0 Pulmonary valve stenosis
0.000 0.419 0.581
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.000 0.421 0.579
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.000 0.421 0.579
I74.0 Embolism and thrombosis of abdominal aorta
0.000 0.421 0.579
I20.1 Angina pectoris with documented spasm
0.000 0.422 0.578
I10 Essential (primary) hypertension
0.000 0.424 0.576
I45.8 Other specified conduction disorders
0.000 0.427 0.573
I77.9 Disorder of arteries and arterioles, unspecified
0.000 0.428 0.572
I34.0 Mitral (valve) insufficiency
0.000 0.428 0.572
I78 Diseases of capillaries
0.000 0.431 0.569
I42.6 Alcoholic cardiomyopathy
0.000 0.436 0.564
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.436 0.564
I49.2 Junctional premature depolarisation
0.000 0.437 0.563
I51.0 Cardiac septal defect, acquired
0.000 0.437 0.563
E78.2 Mixed hyperlipidaemia
0.000 0.437 0.563
I77.8 Other specified disorders of arteries and arterioles
0.000 0.440 0.560
I70.9 Generalised and unspecified atherosclerosis
0.000 0.442 0.558
I70.8 Atherosclerosis of other arteries
0.000 0.442 0.558
I70.1 Atherosclerosis of renal artery
0.000 0.442 0.558
I71 Aortic aneurysm and dissection
0.000 0.444 0.556
I51.5 Myocardial degeneration
0.000 0.444 0.556
I51.3 Intracardiac thrombosis, not elsewhere classified
0.000 0.444 0.556
I51.2 Rupture of papillary muscle, not elsewhere classified
0.000 0.444 0.556
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.000 0.444 0.556
I11 Hypertensive heart disease
0.000 0.446 0.554
I34.8 Other nonrheumatic mitral valve disorders
0.000 0.452 0.548
I34.2 Nonrheumatic mitral (valve) stenosis
0.000 0.452 0.548
I51.4 Myocarditis, unspecified
0.000 0.454 0.546
I31.8 Other specified diseases of pericardium
0.000 0.457 0.543
I31.2 Haemopericardium, not elsewhere classified
0.000 0.457 0.543
I31.1 Chronic constrictive pericarditis
0.000 0.457 0.543
I31.0 Chronic adhesive pericarditis
0.000 0.457 0.543
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.000 0.457 0.543
I07 Rheumatic tricuspid valve diseases
0.000 0.458 0.542
I98.2 Oesophageal varices in diseases classified elsewhere
0.000 0.458 0.542
E78.4 Other hyperlipidaemia
0.000 0.459 0.541
I42.7 Cardiomyopathy due to drugs and other external agents
0.000 0.465 0.535
I42.5 Other restrictive cardiomyopathy
0.000 0.465 0.535
I42.4 Endocardial fibroelastosis
0.000 0.465 0.535
I42.3 Endomyocardial (eosinophilic) disease
0.000 0.465 0.535
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.466 0.534
I47.9 Paroxysmal tachycardia, unspecified
0.000 0.470 0.529
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.476 0.524
I79.1 Aortitis in diseases classified elsewhere
0.000 0.476 0.524
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.000 0.476 0.524
I45.6 Preexcitation syndrome
0.000 0.477 0.523
I49.1 Atrial premature depolarisation
0.000 0.477 0.522
I77.6 Arteritis, unspecified
0.000 0.478 0.522
I51.6 Cardiovascular disease, unspecified
0.000 0.479 0.521
I42.1 Obstructive hypertrophic cardiomyopathy
0.000 0.485 0.515
I23.8 Other current complications following acute myocardial infarction
0.000 0.486 0.514
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.486 0.514
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.486 0.514
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.486 0.514
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.486 0.514
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.486 0.514
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.486 0.514
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.486 0.514
I02 Rheumatic chorea
0.000 0.486 0.514
I01 Rheumatic fever with heart involvement
0.000 0.486 0.514
I00 Rheumatic fever without mention of heart involvement
0.000 0.486 0.514
I13 Hypertensive heart and renal disease
0.000 0.488 0.512
I32.8 Pericarditis in other diseases classified elsewhere
0.000 0.488 0.512
I32.1 Pericarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.488 0.512
I32.0 Pericarditis in bacterial diseases classified elsewhere
0.000 0.488 0.512
I39.8 Endocarditis, valve unspecified, in diseases classified elsewhere
0.000 0.488 0.512
I39.4 Multiple valve disorders in diseases classified elsewhere
0.000 0.488 0.512
I39.3 Pulmonary valve disorders in diseases classified elsewhere
0.000 0.488 0.512
I39.2 Tricuspid valve disorders in diseases classified elsewhere
0.000 0.488 0.512
I39.1 Aortic valve disorders in diseases classified elsewhere
0.000 0.488 0.512
I39.0 Mitral valve disorders in diseases classified elsewhere
0.000 0.488 0.512
I40.9 Acute myocarditis, unspecified
0.000 0.488 0.512
I40.8 Other acute myocarditis
0.000 0.488 0.512
I40.1 Isolated myocarditis
0.000 0.488 0.512
I40.0 Infective myocarditis
0.000 0.488 0.512
I41.8 Myocarditis in other diseases classified elsewhere
0.000 0.488 0.512
I41.2 Myocarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.488 0.512
I41.1 Myocarditis in viral diseases classified elsewhere
0.000 0.488 0.512
I41.0 Myocarditis in bacterial diseases classified elsewhere
0.000 0.488 0.512
I43.8 Cardiomyopathy in other diseases classified elsewhere
0.000 0.488 0.512
I43.2 Cardiomyopathy in nutritional diseases
0.000 0.488 0.512
I43.1 Cardiomyopathy in metabolic diseases
0.000 0.488 0.512
I43.0 Cardiomyopathy in infectious and parasitic diseases classified elsewhere
0.000 0.488 0.512
I48.9 Atrial fibrillation and atrial flutter, unspecified
0.000 0.488 0.512
I48.4 Atypical atrial flutter
0.000 0.488 0.512
I48.3 Typical atrial flutter
0.000 0.488 0.512
I48.2 Chronic atrial fibrillation
0.000 0.488 0.512
I48.1 Persistent atrial fibrillation
0.000 0.488 0.512
I48.0 Paroxysmal atrial fibrillation
0.000 0.488 0.512
I52.8 Other heart disorders in other diseases classified elsewhere
0.000 0.488 0.512
I52.1 Other heart disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.488 0.512
I52.0 Other heart disorders in bacterial diseases classified elsewhere
0.000 0.488 0.512
I34.1 Mitral (valve) prolapse
0.000 0.494 0.506
I30.9 Acute pericarditis, unspecified
0.000 0.499 0.501
I06.9 Rheumatic aortic valve disease, unspecified
0.000 0.500 0.500
I06.8 Other rheumatic aortic valve diseases
0.000 0.500 0.500
I06.2 Rheumatic aortic stenosis with insufficiency
0.000 0.500 0.500
I06.1 Rheumatic aortic insufficiency
0.000 0.500 0.500
I06.0 Rheumatic aortic stenosis
0.000 0.500 0.500
I09.9 Rheumatic heart disease, unspecified
0.000 0.500 0.500
I09.8 Other specified rheumatic heart diseases
0.000 0.500 0.500
I09.2 Chronic rheumatic pericarditis
0.000 0.500 0.500
I09.1 Rheumatic diseases of endocardium, valve unspecified
0.000 0.500 0.500
I09.0 Rheumatic myocarditis
0.000 0.500 0.500
I36.9 Nonrheumatic tricuspid valve disorder, unspecified
0.000 0.501 0.499
I36.8 Other nonrheumatic tricuspid valve disorders
0.000 0.501 0.499
I36.2 Nonrheumatic tricuspid (valve) stenosis with insufficiency
0.000 0.501 0.499
I36.0 Nonrheumatic tricuspid (valve) stenosis
0.000 0.501 0.499
I49.4 Other and unspecified premature depolarisation
0.000 0.502 0.498
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.504 0.496
I46.9 Cardiac arrest, unspecified
0.000 0.504 0.496
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.505 0.495
I30.8 Other forms of acute pericarditis
0.000 0.506 0.494
I30.0 Acute nonspecific idiopathic pericarditis
0.000 0.506 0.494
I33.9 Acute endocarditis, unspecified
0.000 0.508 0.491
I15 Secondary hypertension
0.000 0.510 0.490
E78.1 Pure hyperglyceridaemia
0.000 0.510 0.489
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.511 0.488
E78.6 Lipoprotein deficiency
0.000 0.514 0.486
E78.3 Hyperchylomicronaemia
0.000 0.514 0.486
E78.5 Hyperlipidaemia, unspecified
0.000 0.516 0.484
I36.1 Nonrheumatic tricuspid (valve) insufficiency
0.000 0.519 0.481
I70.00 Atherosclerosis of aorta (without gangrene)
0.000 0.530 0.470
I33.0 Acute and subacute infective endocarditis
0.000 0.537 0.463
I30.1 Infective pericarditis
0.000 0.539 0.461
I74.9 Embolism and thrombosis of unspecified artery
0.000 0.540 0.460
I42.2 Other hypertrophic cardiomyopathy
0.000 0.541 0.459
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.000 0.542 0.458
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.545 0.455
I70.20 Atherosclerosis of arteries of extremities (without gangrene)
0.000 0.547 0.452
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.000 0.549 0.451
I44.7 Left bundle-branch block, unspecified
0.000 0.550 0.450
E78.8 Other disorders of lipoprotein metabolism
0.000 0.555 0.445
I78.0 Hereditary haemorrhagic telangiectasia
0.000 0.561 0.439
I98.8 Other specified disorders of circulatory system in diseases classified elsewhere
0.000 0.566 0.434
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere
0.000 0.566 0.434
I98.1 Cardiovascular disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.566 0.434
I98.0 Cardiovascular syphilis
0.000 0.566 0.434
I42.8 Other cardiomyopathies
0.000 0.567 0.433
I70.01 Atherosclerosis of aorta (with gangrene)
0.000 0.571 0.429
I95 Hypotension
0.000 0.571 0.429
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.572 0.428
I70.21 Atherosclerosis of arteries of extremities (with gangrene)
0.000 0.578 0.422
I51.7 Cardiomegaly
0.000 0.579 0.421
I71.0 Dissection of aorta [any part]
0.000 0.583 0.417
I38 Endocarditis, valve unspecified
0.000 0.587 0.412
I31.3 Pericardial effusion (noninflammatory)
0.000 0.588 0.412
I78.9 Disease of capillaries, unspecified
0.000 0.592 0.408
I78.8 Other diseases of capillaries
0.000 0.595 0.404
I20.8 Other forms of angina pectoris
0.000 0.599 0.401
I70.11 Atherosclerosis of renal artery (with gangrene)
0.000 0.600 0.400
I70.10 Atherosclerosis of renal artery (without gangrene)
0.000 0.600 0.400
I70.81 Atherosclerosis of other arteries (with gangrene)
0.000 0.600 0.400
I70.80 Atherosclerosis of other arteries (without gangrene)
0.000 0.600 0.400
I70.91 Generalized and unspecified atherosclerosis (with gangrene)
0.000 0.600 0.400
I70.90 Generalized and unspecified atherosclerosis (without gangrene)
0.000 0.600 0.400
I71.8 Aortic aneurysm of unspecified site, ruptured
0.000 0.601 0.399
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.000 0.601 0.399
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.000 0.601 0.399
I71.1 Thoracic aortic aneurysm, ruptured
0.000 0.601 0.399
I77.0 Arteriovenous fistula, acquired
0.001 0.603 0.396
I07.9 Tricuspid valve disease, unspecified
0.000 0.611 0.389
I07.8 Other tricuspid valve diseases
0.000 0.611 0.389
I07.2 Tricuspid stenosis with insufficiency
0.000 0.611 0.389
I07.0 Tricuspid stenosis
0.000 0.611 0.389
I97.1 Other functional disturbances following cardiac surgery
0.000 0.622 0.378
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.626 0.374
I12 Hypertensive renal disease
0.000 0.626 0.374
I71.3 Abdominal aortic aneurysm, ruptured
0.000 0.631 0.369
I01.9 Acute rheumatic heart disease, unspecified
0.000 0.631 0.368
I01.8 Other acute rheumatic heart disease
0.000 0.631 0.368
I01.2 Acute rheumatic myocarditis
0.000 0.631 0.368
I01.1 Acute rheumatic endocarditis
0.000 0.631 0.368
I01.0 Acute rheumatic pericarditis
0.000 0.631 0.368
I02.9 Rheumatic chorea without heart involvement
0.000 0.631 0.368
I02.0 Rheumatic chorea with heart involvement
0.000 0.631 0.368
I95.9 Hypotension, unspecified
0.000 0.632 0.368
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.633 0.367
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.633 0.367
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.633 0.367
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.633 0.367
I42.9 Cardiomyopathy, unspecified
0.000 0.643 0.356
I99 Other and unspecified disorders of circulatory system
0.000 0.648 0.352
I15.8 Other secondary hypertension
0.000 0.648 0.351
I15.2 Hypertension secondary to endocrine disorders
0.000 0.648 0.351
I15.1 Hypertension secondary to other renal disorders
0.000 0.648 0.351
I15.0 Renovascular hypertension
0.000 0.648 0.351
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.000 0.649 0.351
I97.9 Postprocedural disorder of circulatory system, unspecified
0.000 0.649 0.350
I97.8 Other postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.649 0.350
I97.0 Postcardiotomy syndrome
0.000 0.649 0.350
E70-E90 Metabolic disorders
0.000 0.651 0.349
I60-I69 Cerebrovascular diseases
0.000 0.660 0.340
E87 Other disorders of fluid, electrolyte and acid-base balance
0.000 0.660 0.340
I95.8 Other hypotension
0.000 0.666 0.334
I15.9 Seconday hypertension, unspecified
0.000 0.670 0.330
I95.1 Orthostatic hypotension
0.000 0.684 0.316
E87.1 Hypo-osmolality and hyponatraemia
0.000 0.691 0.309
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.692 0.308
I97.2 Postmastectomy lymphoedema syndrome
0.000 0.695 0.305
I28 Other diseases of pulmonary vessels
0.000 0.699 0.301
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.000 0.699 0.301
E87.7 Fluid overload
0.000 0.712 0.288
I65.2 Occlusion and stenosis of carotid artery
0.000 0.714 0.286
E80.4 Gilbert's syndrome
0.000 0.721 0.279
E87.2 Acidosis
0.000 0.723 0.277
I27 Other pulmonary heart diseases
0.000 0.724 0.276
E87.6 Hypokalaemia
0.000 0.725 0.275
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.000 0.737 0.263
I12.9 Hypertensive renal disease without renal failure
0.000 0.737 0.263
E73 Lactose intolerance
0.000 0.740 0.260
I67 Other cerebrovascular diseases
0.000 0.748 0.252
E87.3 Alkalosis
0.000 0.749 0.250
E84 Cystic fibrosis
0.000 0.750 0.250
E79 Disorders of purine and pyrimidine metabolism
0.000 0.750 0.250
E77 Disorders of glycoprotein metabolism
0.000 0.750 0.250
E76 Disorders of glycosaminoglycan metabolism
0.000 0.750 0.250
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.750 0.250
E72 Other disorders of amino-acid metabolism
0.000 0.750 0.250
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.750 0.250
E70 Disorders of aromatic amino-acid metabolism
0.000 0.750 0.250
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.750 0.250
E87.0 Hyperosmolality and hypernatraemia
0.000 0.753 0.247
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.000 0.756 0.244
E87.4 Mixed disorder of acid-base balance
0.000 0.756 0.244
I60 Subarachnoid haemorrhage
0.000 0.757 0.243
I69 Sequelae of cerebrovascular disease
0.000 0.763 0.237
I07.1 Tricuspid insufficiency
0.001 0.766 0.234
I67.9 Cerebrovascular disease, unspecified
0.000 0.768 0.232
I26 Pulmonary embolism
0.000 0.769 0.230
E74 Other disorders of carbohydrate metabolism
0.000 0.772 0.227
I35 Nonrheumatic aortic valve disorders
0.000 0.774 0.226
I68 Cerebrovascular disorders in diseases classified elsewhere
0.000 0.777 0.222
E85 Amyloidosis
0.000 0.778 0.222
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.779 0.221
E80.6 Other disorders of bilirubin metabolism
0.000 0.779 0.221
E80.5 Crigler-Najjar syndrome
0.000 0.779 0.221
E80.3 Defects of catalase and peroxydase
0.000 0.779 0.221
E80.2 Other porphyria
0.000 0.779 0.221
E80.1 Porphyria cutanea tarda
0.000 0.779 0.221
E80.0 Hereditary erythropoietic porphyria
0.000 0.779 0.221
Z95.1 Presence of aortocoronary bypass graft
0.000 0.781 0.219
E87.5 Hyperkalaemia
0.000 0.782 0.217
I28.9 Disease of pulmonary vessels, unspecified
0.000 0.784 0.216
I28.1 Aneurysm of pulmonary artery
0.000 0.784 0.216
I28.0 Arteriovenous fistula of pulmonary vessels
0.000 0.784 0.216
I65.9 Occlusion and stenosis of unspecified precerebral artery
0.000 0.784 0.216
I65.8 Occlusion and stenosis of other precerebral artery
0.000 0.784 0.216
I65.3 Occlusion and stenosis of multiple and bilateral precerebral arteries
0.000 0.784 0.216
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.000 0.786 0.214
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.788 0.212
I60.3 Subarachnoid haemorrhage from posterior communicating artery
0.000 0.788 0.212
I69.3 Sequelae of cerebral infarction
0.000 0.791 0.209
Z95 Presence of cardiac and vascular implants and grafts
0.000 0.795 0.205
I49.5 Sick sinus syndrome
0.001 0.796 0.203
I62 Other nontraumatic intracranial haemorrhage
0.000 0.797 0.203
I78.1 Naevus, nonneoplastic
0.000 0.799 0.200
I60.8 Other subarachnoid haemorrhage
0.000 0.801 0.198
I27.1 Kyphoscoliotic heart disease
0.000 0.802 0.198
E73.9 Lactose intolerance, unspecified
0.000 0.803 0.197
Z95.5 Presence of coronary angioplasty implant and graft
0.000 0.805 0.195
I27.2 Other secondary pulmonary hypertension
0.000 0.805 0.195
I95.0 Idiopathic hypotension
0.001 0.807 0.192
I65.0 Occlusion and stenosis of vertebral artery
0.000 0.808 0.192
Z95.0 Presence of cardiac pacemaker
0.000 0.810 0.190
I27.8 Other specified pulmonary heart diseases
0.000 0.811 0.189
I28.8 Other specified diseases of pulmonary vessels
0.000 0.811 0.188
I63 Cerebral infarction
0.000 0.812 0.188
E73.8 Other lactose intolerance
0.000 0.813 0.187
E73.1 Secondary lactase deficiency
0.000 0.813 0.187
E73.0 Congenital lactase deficiency
0.000 0.813 0.187
I27.0 Primary pulmonary hypertension
0.000 0.813 0.187
I67.2 Cerebral atherosclerosis
0.000 0.816 0.184
I67.7 Cerebral arteritis, not elsewhere classified
0.000 0.819 0.181
I67.6 Nonpyogenic thrombosis of intracranial venous system
0.000 0.819 0.181
I67.5 Moyamoya disease
0.000 0.819 0.181
I67.4 Hypertensive encephalopathy
0.000 0.819 0.181
I67.3 Progressive vascular leukoencephalopathy
0.000 0.819 0.181
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.820 0.179
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.820 0.179
E70.3 Albinism
0.000 0.820 0.179
E70.2 Disorders of tyrosine metabolism
0.000 0.820 0.179
E70.1 Other hyperphenylalaninaemias
0.000 0.820 0.179
E70.0 Classical phenylketonuria
0.000 0.820 0.179
E71.3 Disorders of fatty-acid metabolism
0.000 0.820 0.179
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.820 0.179
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.820 0.179
E71.0 Maple-syrup-urine disease
0.000 0.820 0.179
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.820 0.179
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.820 0.179
E72.5 Disorders of glycine metabolism
0.000 0.820 0.179
E72.4 Disorders of ornithine metabolism
0.000 0.820 0.179
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.820 0.179
E72.2 Disorders of urea cycle metabolism
0.000 0.820 0.179
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.820 0.179
E72.0 Disorders of amino-acid transport
0.000 0.820 0.179
E75.6 Lipid storage disorder, unspecified
0.000 0.820 0.179
E75.5 Other lipid storage disorders
0.000 0.820 0.179
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.820 0.179
E75.3 Sphingolipidosis, unspecified
0.000 0.820 0.179
E75.2 Other sphingolipidosis
0.000 0.820 0.179
E75.1 Other gangliosidosis
0.000 0.820 0.179
E75.0 GM2 gangliosidosis
0.000 0.820 0.179
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.820 0.179
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.820 0.179
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.820 0.179
E76.2 Other mucopolysaccharidoses
0.000 0.820 0.179
E76.1 Mucopolysaccharidosis, type II
0.000 0.820 0.179
E76.0 Mucopolysaccharidosis, type I
0.000 0.820 0.179
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.820 0.179
E77.8 Other disorders of glycoprotein metabolism
0.000 0.820 0.179
E77.1 Defects in glycoprotein degradation
0.000 0.820 0.179
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.820 0.179
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.820 0.179
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.820 0.179
E79.1 Lesch-Nyhan syndrome
0.000 0.820 0.179
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.820 0.179
E84.9 Cystic fibrosis, unspecified
0.000 0.820 0.179
E84.8 Cystic fibrosis with other manifestations
0.000 0.820 0.179
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.820 0.179
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.820 0.179
I27.9 Pulmonary heart disease, unspecified
0.000 0.823 0.177
I66.9 Occlusion and stenosis of unspecified cerebral artery
0.000 0.825 0.175
I66.8 Occlusion and stenosis of other cerebral artery
0.000 0.825 0.175
I66.4 Occlusion and stenosis of multiple and bilateral cerebral arteries
0.000 0.825 0.175
I66.3 Occlusion and stenosis of cerebellar arteries
0.000 0.825 0.175
I66.2 Occlusion and stenosis of posterior cerebral artery
0.000 0.825 0.175
I66.1 Occlusion and stenosis of anterior cerebral artery
0.000 0.825 0.175
I66.0 Occlusion and stenosis of middle cerebral artery
0.000 0.825 0.175
Z95.9 Presence of cardiac and vascular implant and graft, unspecified
0.000 0.825 0.175
I60.7 Subarachnoid haemorrhage from intracranial artery, unspecified
0.000 0.826 0.174
I60.5 Subarachnoid haemorrhage from vertebral artery
0.000 0.826 0.174
I60.4 Subarachnoid haemorrhage from basilar artery
0.000 0.826 0.174
I60.0 Subarachnoid haemorrhage from carotid siphon and bifurcation
0.000 0.826 0.174
I64 Stroke, not specified as haemorrhage or infarction
0.000 0.826 0.174
I65.1 Occlusion and stenosis of basilar artery
0.000 0.827 0.172
I69.8 Sequelae of other and unspecified cerebrovascular diseases
0.000 0.827 0.172
E89.2 Postprocedural hypoparathyroidism
0.000 0.829 0.171
E86 Volume depletion
0.000 0.830 0.170
I63.5 Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
0.000 0.832 0.168
I60.9 Subarachnoid haemorrhage, unspecified
0.000 0.833 0.167
I67.0 Dissection of cerebral arteries, nonruptured
0.000 0.833 0.167
I95.2 Hypotension due to drugs
0.001 0.835 0.164
I35.2 Aortic (valve) stenosis with insufficiency
0.000 0.836 0.164
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.837 0.163
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.837 0.163
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.837 0.163
E74.2 Disorders of galactose metabolism
0.000 0.837 0.163
E74.1 Disorders of fructose metabolism
0.000 0.837 0.163
E74.0 Glycogen storage disease
0.000 0.837 0.163
I35.8 Other aortic valve disorders
0.000 0.837 0.163
I69.1 Sequelae of intracerebral haemorrhage
0.000 0.837 0.162
I67.1 Cerebral aneurysm, nonruptured
0.000 0.839 0.161
I68.8 Other cerebrovascular disorders in diseases classified elsewhere
0.000 0.840 0.160
I68.2 Cerebral arteritis in other diseases classified elsewhere
0.000 0.840 0.160
I68.1 Cerebral arteritis in infectious and parasitic diseases classified elsewhere
0.000 0.840 0.160
E85.8 Other amyloidosis
0.000 0.840 0.159
E85.3 Secondary systemic amyloidosis
0.000 0.840 0.159
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.840 0.159
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.840 0.159
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.840 0.159
E89.3 Postprocedural hypopituitarism
0.000 0.841 0.159

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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