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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2071590
log Bayes Factor = 76.0032
Chromosome 6   position 31,539,768  (GRCh37) Explore rs2071590 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
I20 Angina pectoris
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.001 0.999
E10.1 With ketoacidosis
0.000 0.001 0.999
I20.0 Unstable angina
0.000 0.001 0.999
M06.9 Rheumatoid arthritis, unspecified
0.000 0.001 0.999
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.003 0.997
E10.4 With neurological complications
0.000 0.003 0.997
E78.0 Pure hypercholesterolaemia
0.000 0.005 0.995
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.005 0.995
E70-E90 Metabolic disorders
0.000 0.005 0.995
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.005 0.995
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.006 0.994
I20.9 Angina pectoris, unspecified
0.000 0.006 0.994
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.017 0.983
E14.3 With ophthalmic complications
0.000 0.017 0.983
I22 Subsequent myocardial infarction
0.000 0.024 0.976
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.026 0.974
E16 Other disorders of pancreatic internal secretion
0.000 0.029 0.971
E14.9 Without complications
0.000 0.031 0.969
I25.5 Ischaemic cardiomyopathy
0.000 0.033 0.967
E16.2 Hypoglycaemia, unspecified
0.000 0.041 0.959
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.042 0.958
E11.1 With ketoacidosis
0.000 0.048 0.952
E10.2 With renal complications
0.000 0.061 0.939
I21 Acute myocardial infarction
0.000 0.062 0.938
I21.9 Acute myocardial infarction, unspecified
0.000 0.074 0.926
I25.2 Old myocardial infarction
0.000 0.077 0.923
E11.3 With ophthalmic complications
0.000 0.078 0.922
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.090 0.910
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.095 0.905
E06 Thyroiditis
0.000 0.115 0.885
E14.4 With neurological complications
0.000 0.119 0.881
E11.2 With renal complications
0.000 0.127 0.873
M06 Other rheumatoid arthritis
0.000 0.132 0.868
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.132 0.868
E13 Other specified diabetes mellitus
0.000 0.138 0.862
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.139 0.861
E10.0 With coma
0.000 0.145 0.855
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.147 0.853
E11.0 With coma
0.000 0.154 0.846
E78.1 Pure hyperglyceridaemia
0.000 0.160 0.840
E40-E46 Malnutrition
0.000 0.161 0.839
E14.8 With unspecified complications
0.000 0.165 0.835
I24 Other acute ischaemic heart diseases
0.000 0.167 0.833
E78.2 Mixed hyperlipidaemia
0.000 0.179 0.821
E06.3 Autoimmune thyroiditis
0.000 0.185 0.815
E14.6 With other specified complications
0.000 0.185 0.814
E10.8 With unspecified complications
0.000 0.187 0.813
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.188 0.812
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.190 0.810
E88 Other metabolic disorders
0.000 0.204 0.796
E86 Volume depletion
0.000 0.205 0.795
E10.5 With peripheral circulatory complications
0.000 0.213 0.787
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.213 0.787
M06.3 Rheumatoid nodule
0.000 0.213 0.787
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.215 0.785
M06.0 Seronegative rheumatoid arthritis
0.000 0.221 0.779
I23 Certain current complications following acute myocardial infarction
0.000 0.226 0.773
E14.1 With ketoacidosis
0.000 0.227 0.773
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.229 0.771
L40.5 Arthropathic psoriasis
0.000 0.242 0.758
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.243 0.757
E13.9 Without complications
0.000 0.248 0.752
L40 Psoriasis
0.000 0.249 0.751
E78.6 Lipoprotein deficiency
0.000 0.250 0.750
E74 Other disorders of carbohydrate metabolism
0.000 0.254 0.746
E14.5 With peripheral circulatory complications
0.000 0.256 0.744
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.259 0.741
E78.4 Other hyperlipidaemia
0.000 0.260 0.740
I25.6 Silent myocardial ischaemia
0.000 0.264 0.735
E73 Lactose intolerance
0.000 0.265 0.735
E10.6 With other specified complications
0.000 0.265 0.735
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.274 0.726
E46 Unspecified protein-energy malnutrition
0.000 0.276 0.724
E83.1 Disorders of iron metabolism
0.724 0.276 0.000
L40-L45 Papulosquamous disorders
0.000 0.276 0.724
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.282 0.718
E10.7 With multiple complications
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
L43 Lichen planus
0.000 0.286 0.714
E78.3 Hyperchylomicronaemia
0.000 0.286 0.713
E77 Disorders of glycoprotein metabolism
0.000 0.286 0.713
E76 Disorders of glycosaminoglycan metabolism
0.000 0.286 0.713
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.286 0.713
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.286 0.713
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.287 0.713
I24.8 Other forms of acute ischaemic heart disease
0.000 0.290 0.710
E14.2 Withrenal complications
0.000 0.291 0.708
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.292 0.708
E79 Disorders of purine and pyrimidine metabolism
0.000 0.293 0.707
E15 Nondiabetic hypoglycaemic coma
0.000 0.295 0.705
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.297 0.703
L40.9 Psoriasis, unspecified
0.000 0.297 0.703
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.300 0.700
E70 Disorders of aromatic amino-acid metabolism
0.000 0.300 0.700
L43.9 Lichen planus, unspecified
0.000 0.301 0.699
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.304 0.696
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.304 0.696
E16.4 Abnormal secretion of gastrin
0.000 0.304 0.696
E16.3 Increased secretion of glucagon
0.000 0.304 0.696
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.306 0.694
E84 Cystic fibrosis
0.000 0.314 0.686
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.323 0.677
E06.5 Other chronic thyroiditis
0.000 0.324 0.676
E72 Other disorders of amino-acid metabolism
0.000 0.327 0.673
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.327 0.673
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.327 0.673
E89.3 Postprocedural hypopituitarism
0.000 0.331 0.669
M06.34 Rheumatoid nodule (Hand)
0.000 0.334 0.666
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.340 0.660
E16.1 Other hypoglycaemia
0.000 0.342 0.657
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.354 0.646
E13.3 With ophthalmic complications
0.000 0.358 0.642
I25.4 Coronary artery aneurysm
0.000 0.360 0.640
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.364 0.636
E06.4 Drug-induced thyroiditis
0.000 0.365 0.635
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.365 0.635
E06.0 Acute thyroiditis
0.000 0.365 0.635
I22.8 Subsequent myocardial infarction of other sites
0.000 0.372 0.628
E78.8 Other disorders of lipoprotein metabolism
0.000 0.374 0.626
M06.8 Other specified rheumatoid arthritis
0.000 0.377 0.623
M06.2 Rheumatoid bursitis
0.000 0.377 0.623
M06.1 Adult-onset Still's disease
0.000 0.377 0.623
E80.6 Other disorders of bilirubin metabolism
0.000 0.378 0.622
E20-E35 Disorders of other endocrine glands
0.000 0.378 0.622
E88.2 Lipomatosis, not elsewhere classified
0.000 0.379 0.621
L43.8 Other lichen planus
0.000 0.380 0.620
E13.8 With unspecified complications
0.000 0.382 0.618
E13.7 With multiple complications
0.000 0.382 0.618
E13.6 With other specified complications
0.000 0.382 0.618
E13.5 With peripheral circulatory complications
0.000 0.382 0.618
E13.4 With neurological complications
0.000 0.382 0.618
E13.2 With renal complications
0.000 0.382 0.618
E13.1 With ketoacidosis
0.000 0.382 0.618
E13.0 With coma
0.000 0.382 0.618
E14.0 With coma
0.000 0.383 0.617
K90 Intestinal malabsorption
0.000 0.387 0.613
I23.8 Other current complications following acute myocardial infarction
0.000 0.389 0.611
I20.1 Angina pectoris with documented spasm
0.000 0.392 0.608
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.392 0.607
E06.9 Thyroiditis, unspecified
0.000 0.397 0.603
E89.0 Postprocedural hypothyroidism
0.000 0.397 0.603
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.398 0.602
E45 Retarded development following protein-energy malnutrition
0.000 0.398 0.602
E43 Unspecified severe protein-energy malnutrition
0.000 0.398 0.602
E42 Marasmic kwashiorkor
0.000 0.398 0.602
E41 Nutritional marasmus
0.000 0.398 0.602
E40 Kwashiorkor
0.000 0.398 0.602
E88.9 Metabolic disorder, unspecified
0.000 0.400 0.600
L40.8 Other psoriasis
0.000 0.407 0.593
E11.5 With peripheral circulatory complications
0.000 0.409 0.591
E88.8 Other specified metabolic disorders
0.000 0.414 0.586
E11.6 With other specified complications
0.000 0.417 0.583
E88.3 Tumour lysis syndrome
0.000 0.417 0.583
E11.8 With unspecified complications
0.000 0.418 0.582
E06.1 Subacute thyroiditis
0.000 0.426 0.573
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.429 0.571
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.432 0.568
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.436 0.564
M06.38 Rheumatoid nodule (Other)
0.000 0.436 0.564
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.436 0.564
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.436 0.564
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.436 0.564
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.437 0.563
L40.4 Guttate psoriasis
0.000 0.439 0.561
E23 Hypofunction and other disorders of pituitary gland
0.000 0.440 0.560
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.441 0.559
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.441 0.559
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.441 0.559
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.441 0.559
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.441 0.559
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.445 0.555
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.445 0.555
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.445 0.555
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.445 0.555
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.445 0.555
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.445 0.555
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.445 0.555
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.445 0.555
E03.1 Congenital hypothyroidism without goitre
0.000 0.447 0.553
I25.3 Aneurysm of heart
0.000 0.448 0.551
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.450 0.549
E73.9 Lactose intolerance, unspecified
0.000 0.451 0.549
E89.4 Postprocedural ovarian failure
0.000 0.451 0.549
M06.4 Inflammatory polyarthropathy
0.000 0.451 0.549
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.453 0.547
L40.3 Pustulosis palmaris et plantaris
0.000 0.454 0.545
E85 Amyloidosis
0.000 0.456 0.544
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.457 0.543
E89.5 Postprocedural testicular hypofunction
0.000 0.457 0.543
E89.1 Postprocedural hypoinsulinaemia
0.000 0.457 0.543
L40.2 Acrodermatitis continua
0.000 0.461 0.538
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.465 0.535
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.465 0.535
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.465 0.535
E74.2 Disorders of galactose metabolism
0.000 0.465 0.535
E74.1 Disorders of fructose metabolism
0.000 0.465 0.535
E74.0 Glycogen storage disease
0.000 0.465 0.535
E80.1 Porphyria cutanea tarda
0.000 0.471 0.529
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.472 0.528
E73.8 Other lactose intolerance
0.000 0.473 0.527
E73.1 Secondary lactase deficiency
0.000 0.473 0.527
E73.0 Congenital lactase deficiency
0.000 0.473 0.527
L42 Pityriasis rosea
0.000 0.474 0.526
H36.0 Diabetic retinopathy
0.000 0.478 0.522
E80.2 Other porphyria
0.000 0.479 0.521
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.479 0.521
E80.5 Crigler-Najjar syndrome
0.000 0.479 0.521
E80.3 Defects of catalase and peroxydase
0.000 0.479 0.521
E80.0 Hereditary erythropoietic porphyria
0.000 0.479 0.521
L44 Other papulosquamous disorders
0.000 0.481 0.519
L41 Parapsoriasis
0.000 0.481 0.519
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.481 0.519
L40.1 Generalised pustular psoriasis
0.000 0.482 0.518
E05.8 Other thyrotoxicosis
0.000 0.484 0.516
E23.6 Other disorders of pituitary gland
0.000 0.484 0.516
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.488 0.512
L43.3 Subacute (active) lichen planus
0.000 0.488 0.512
L43.2 Lichenoid drug reaction
0.000 0.488 0.512
L43.1 Bullous lichen planus
0.000 0.488 0.512
L43.0 Hypertrophic lichen planus
0.000 0.488 0.512
E71.3 Disorders of fatty-acid metabolism
0.000 0.488 0.511
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.488 0.511
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.488 0.511
E71.0 Maple-syrup-urine disease
0.000 0.488 0.511
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.488 0.511
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.488 0.511
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.488 0.511
E76.2 Other mucopolysaccharidoses
0.000 0.488 0.511
E76.1 Mucopolysaccharidosis, type II
0.000 0.488 0.511
E76.0 Mucopolysaccharidosis, type I
0.000 0.488 0.511
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.488 0.511
E77.8 Other disorders of glycoprotein metabolism
0.000 0.488 0.511
E77.1 Defects in glycoprotein degradation
0.000 0.488 0.511
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.488 0.511
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.493 0.507
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.493 0.507
E79.1 Lesch-Nyhan syndrome
0.000 0.493 0.507
E07 Other disorders of thyroid
0.000 0.494 0.506
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.498 0.502
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.498 0.502
E70.2 Disorders of tyrosine metabolism
0.000 0.498 0.502
E70.1 Other hyperphenylalaninaemias
0.000 0.498 0.502
E70.0 Classical phenylketonuria
0.000 0.498 0.502
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.500 0.500
E24 Cushing's syndrome
0.000 0.501 0.499
E84.8 Cystic fibrosis with other manifestations
0.000 0.508 0.492
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.508 0.492
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.508 0.492
K90.9 Intestinal malabsorption, unspecified
0.000 0.511 0.489
E70.3 Albinism
0.000 0.511 0.488
E65-E68 Obesity and other hyperalimentation
0.000 0.512 0.488
E03.8 Other specified hypothyroidism
0.000 0.513 0.487
M06.33 Rheumatoid nodule (Forearm)
0.000 0.515 0.485
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.517 0.483
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.517 0.483
E72.5 Disorders of glycine metabolism
0.000 0.517 0.483
E72.4 Disorders of ornithine metabolism
0.000 0.517 0.483
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.517 0.483
E72.2 Disorders of urea cycle metabolism
0.000 0.517 0.483
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.517 0.483
E75.6 Lipid storage disorder, unspecified
0.000 0.517 0.482
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.517 0.482
E75.3 Sphingolipidosis, unspecified
0.000 0.517 0.482
E75.2 Other sphingolipidosis
0.000 0.517 0.482
E75.1 Other gangliosidosis
0.000 0.517 0.482
E75.0 GM2 gangliosidosis
0.000 0.517 0.482
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.517 0.482
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.522 0.478
E28 Ovarian dysfunction
0.000 0.529 0.471
I21.4 Acute subendocardial myocardial infarction
0.000 0.530 0.470
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.532 0.468
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.535 0.465
E84.9 Cystic fibrosis, unspecified
0.000 0.535 0.465
I24.1 Dressler's syndrome
0.000 0.537 0.462
E23.2 Diabetes insipidus
0.000 0.538 0.462
E23.7 Disorder of pituitary gland, unspecified
0.000 0.541 0.459
L40.0 Psoriasis vulgaris
0.000 0.543 0.457
E22 Hyperfunction of pituitary gland
0.000 0.543 0.457
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.547 0.452
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.553 0.446
M06.18 Adult-onset Still's disease (Other)
0.000 0.553 0.446
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.553 0.446
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.553 0.446
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.553 0.446
M06.14 Adult-onset Still's disease (Hand)
0.000 0.553 0.446
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.553 0.446
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.553 0.446
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.553 0.446
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.553 0.446
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.553 0.446
M06.28 Rheumatoid bursitis (Other)
0.000 0.553 0.446
M06.27 Rheumatoid bursitis (Ankle and foot)
0.000 0.553 0.446
M06.26 Rheumatoid bursitis (Lower leg)
0.000 0.553 0.446
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.000 0.553 0.446
M06.24 Rheumatoid bursitis (Hand)
0.000 0.553 0.446
M06.23 Rheumatoid bursitis (Forearm)
0.000 0.553 0.446
M06.22 Rheumatoid bursitis (Upper arm)
0.000 0.553 0.446
M06.21 Rheumatoid bursitis (Shoulder region)
0.000 0.553 0.446
M06.20 Rheumatoid bursitis (Multiple sites)
0.000 0.553 0.446
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.000 0.553 0.446
M06.88 Other specified rheumatoid arthritis (Other)
0.000 0.553 0.446
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.000 0.553 0.446
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.000 0.553 0.446
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.000 0.553 0.446
M06.84 Other specified rheumatoid arthritis (Hand)
0.000 0.553 0.446
M06.83 Other specified rheumatoid arthritis (Forearm)
0.000 0.553 0.446
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.000 0.553 0.446
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.000 0.553 0.446
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.000 0.553 0.446
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.554 0.446
E32 Diseases of thymus
0.000 0.554 0.446
E31 Polyglandular dysfunction
0.000 0.554 0.446
E30 Disorders of puberty, not elsewhere classified
0.000 0.554 0.446
E26 Hyperaldosteronism
0.000 0.555 0.445
E72.0 Disorders of amino-acid transport
0.000 0.557 0.442
E75.5 Other lipid storage disorders
0.000 0.558 0.442
K90.3 Pancreatic steatorrhoea
0.000 0.561 0.439
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.561 0.439
K90.1 Tropical sprue
0.000 0.561 0.439
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.563 0.437
D64.9 Anaemia, unspecified
0.000 0.563 0.437
E44.1 Mild protein-energy malnutrition
0.000 0.568 0.431
E44.0 Moderate protein-energy malnutrition
0.000 0.568 0.431
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.568 0.431
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.571 0.429
E21.3 Hyperparathyroidism, unspecified
0.000 0.580 0.420
E85.4 Organ-limited amyloidosis
0.000 0.584 0.416
I10 Essential (primary) hypertension
0.000 0.586 0.414
D64 Other anaemias
0.000 0.586 0.414
E24.2 Drug-induced Cushing's syndrome
0.000 0.586 0.414
I10-I15 Hypertensive diseases
0.000 0.591 0.409
Chapter IX Diseases of the circulatory system
0.000 0.594 0.406
K90.8 Other intestinal malabsorption
0.000 0.597 0.403
E20 Hypoparathyroidism
0.000 0.597 0.403
D60-D64 Aplastic and other anaemias
0.000 0.597 0.403
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.598 0.402
E23.1 Drug-induced hypopituitarism
0.000 0.598 0.402
E24.0 Pituitary-dependent Cushing's disease
0.000 0.603 0.397
E25 Adrenogenital disorders
0.000 0.603 0.397
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.606 0.393
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.606 0.393
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.606 0.393
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.606 0.393
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.606 0.393
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.606 0.393
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.606 0.393
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.606 0.393
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.610 0.390
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.610 0.390
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.610 0.390
E28.2 Polycystic ovarian syndrome
0.000 0.612 0.388
K90-K93 Other diseases of the digestive system
0.000 0.620 0.380
D61 Other aplastic anaemias
0.000 0.621 0.379
E22.0 Acromegaly and pituitary gigantism
0.000 0.621 0.378
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.627 0.372
L41.9 Parapsoriasis, unspecified
0.000 0.628 0.372
L41.8 Other parapsoriasis
0.000 0.628 0.372
L41.5 Retiform parapsoriasis
0.000 0.628 0.372
L41.4 Large plaque parapsoriasis
0.000 0.628 0.372
L41.3 Small plaque parapsoriasis
0.000 0.628 0.372
L41.2 Lymphomatoid papulosis
0.000 0.628 0.372
L41.1 Pityriasis lichenoides chronica
0.000 0.628 0.372
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.628 0.372
L44.9 Papulosquamous disorder, unspecified
0.000 0.628 0.372
L44.8 Other specified papulosquamous disorders
0.000 0.628 0.372
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.628 0.372
L44.3 Lichen ruber moniliformis
0.000 0.628 0.372
L44.2 Lichen striatus
0.000 0.628 0.372
L44.1 Lichen nitidus
0.000 0.628 0.372
L44.0 Pityriasis rubra pilaris
0.000 0.628 0.372
E65 Localised adiposity
0.000 0.630 0.370
E21.2 Other hyperparathyroidism
0.000 0.631 0.369
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.632 0.368
E07.1 Dyshormogenetic goitre
0.000 0.637 0.363
E07.0 Hypersecretion of calcitonin
0.000 0.637 0.363
E07.8 Other specified disorders of thyroid
0.000 0.638 0.361
I05-I09 Chronic rheumatic heart diseases
0.000 0.639 0.361
D61.9 Aplastic anaemia, unspecified
0.000 0.640 0.360
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.642 0.358
E24.3 Ectopic ACTH syndrome
0.000 0.642 0.358
E24.1 Nelson's syndrome
0.000 0.642 0.358
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.642 0.358
E85.9 Amyloidosis, unspecified
0.000 0.645 0.354
E21.4 Other specified disorders of parathyroid gland
0.000 0.649 0.351
E67 Other hyperalimentation
0.000 0.650 0.350
E68 Sequelae of hyperalimentation
0.000 0.650 0.350
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.652 0.348
E50-E64 Other nutritional deficiencies
0.000 0.654 0.346
I15 Secondary hypertension
0.000 0.655 0.345
E24.8 Other Cushing's syndrome
0.000 0.657 0.343
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.658 0.342
D70 Agranulocytosis
0.000 0.661 0.339
E28.9 Ovarian dysfunction, unspecified
0.000 0.662 0.337
E28.8 Other ovarian dysfunction
0.000 0.662 0.337
E28.1 Androgen excess
0.000 0.662 0.337
E28.0 Oestrogen excess
0.000 0.662 0.337
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.662 0.338
# Top node
0.000 0.663 0.337
I08 Multiple valve diseases
0.000 0.664 0.336
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.667 0.333
E85.3 Secondary systemic amyloidosis
0.000 0.670 0.330
E80.4 Gilbert's syndrome
0.000 0.671 0.329
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.672 0.327
E22.8 Other hyperfunction of pituitary gland
0.000 0.672 0.327
E83 Disorders of mineral metabolism
0.254 0.673 0.074
D63 Anaemia in chronic diseases classified elsewhere
0.000 0.676 0.324
E30.9 Disorder of puberty, unspecified
0.000 0.680 0.320
E30.8 Other disorders of puberty
0.000 0.680 0.320
E30.1 Precocious puberty
0.000 0.680 0.320
E30.0 Delayed puberty
0.000 0.680 0.320
E31.9 Polyglandular dysfunction, unspecified
0.000 0.680 0.320
E31.8 Other polyglandular dysfunction
0.000 0.680 0.320
E31.1 Polyglandular hyperfunction
0.000 0.680 0.320
E31.0 Autoimmune polyglandular failure
0.000 0.680 0.320
E32.9 Disease of thymus, unspecified
0.000 0.680 0.320
E32.8 Other diseases of thymus
0.000 0.680 0.320
E32.1 Abscess of thymus
0.000 0.680 0.320
E32.0 Persistent hyperplasia of thymus
0.000 0.680 0.320
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.680 0.320
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.680 0.320
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.680 0.320
E26.9 Hyperaldosteronism, unspecified
0.000 0.680 0.319
E26.8 Other hyperaldosteronism
0.000 0.680 0.319
E26.1 Secondary hyperaldosteronism
0.000 0.680 0.319
E26.0 Primary hyperaldosteronism
0.000 0.681 0.319
E24.9 Cushing's syndrome, unspecified
0.000 0.681 0.319
E85.8 Other amyloidosis
0.000 0.681 0.318
G35 Multiple sclerosis
0.313 0.687 0.000
K91 Postprocedural disorders of digestive system, not elsewhere classified
0.000 0.692 0.308
E34 Other endocrine disorders
0.000 0.692 0.307
I12 Hypertensive renal disease
0.000 0.694 0.306
Chapter VIII Diseases of the ear and mastoid process
0.000 0.696 0.304
I09 Other rheumatic heart diseases
0.000 0.698 0.302
E29 Testicular dysfunction
0.000 0.700 0.300
Chapter XI Diseases of the digestive system
0.000 0.700 0.300
I08.1 Disorders of both mitral and tricuspid valves
0.000 0.701 0.299
K70-K77 Diseases of liver
0.000 0.701 0.299
D61.1 Drug-induced aplastic anaemia
0.000 0.701 0.299
D64.4 Congenital dyserythropoietic anaemia
0.000 0.703 0.297
D64.3 Other sideroblastic anaemias
0.000 0.703 0.297
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.000 0.703 0.297
D64.1 Secondary sideroblastic anaemia due to disease
0.000 0.703 0.297
D64.0 Hereditary sideroblastic anaemia
0.000 0.703 0.297
H65-H75 Diseases of middle ear and mastoid
0.000 0.704 0.296
E28.3 Primary ovarian failure
0.000 0.704 0.296
E27 Other disorders of adrenal gland
0.000 0.704 0.296
K74 Fibrosis and cirrhosis of liver
0.000 0.707 0.293
H71 Cholesteatoma of middle ear
0.000 0.710 0.290
E20.8 Other hypoparathyroidism
0.000 0.711 0.289
E20.1 Pseudohypoparathyroidism
0.000 0.711 0.289
E20.0 Idiopathic hypoparathyroidism
0.000 0.711 0.289
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.000 0.711 0.289
I08.2 Disorders of both aortic and tricuspid valves
0.000 0.711 0.289

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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