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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2112095
log Bayes Factor = 10.2299
Chromosome 2   position 41,229,015  (GRCh37) Explore rs2112095 on Ensembl!
Variant rs2112095 is part of Cluster X0193

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
E10-E14 Diabetes mellitus
1.000 0.000 0.000
M20-M25 Other joint disorders
0.999 0.001 0.000
Chapter V Mental and behavioural disorders
0.999 0.001 0.000
E11 Non-insulin-dependent diabetes mellitus
0.998 0.002 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.998 0.002 0.000
M45-M49 Spondylopathies
0.991 0.009 0.000
R69 Unknown and unspecified causes of morbidity
0.991 0.009 0.000
Chapter VI Diseases of the nervous system
0.989 0.011 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.989 0.011 0.000
R50-R69 General symptoms and signs
0.988 0.012 0.000
E11.4 With neurological complications
0.987 0.013 0.000
F30-F39 Mood [affective] disorders
0.986 0.014 0.000
R10-R19 Symptoms and signs involving the digestive system and abdomen
0.976 0.024 0.000
M21 Other acquired deformities of limbs
0.974 0.026 0.000
E10 Insulin-dependent diabetes mellitus
0.974 0.026 0.000
M47 Spondylosis
0.971 0.029 0.000
E20-E35 Disorders of other endocrine glands
0.970 0.030 0.000
M65-M68 Disorders of synovium and tendon
0.970 0.030 0.000
R19 Other symptoms and signs involving the digestive system and abdomen
0.969 0.031 0.000
M20 Acquired deformities of fingers and toes
0.961 0.039 0.000
M20.4 Other hammer toe(s) (acquired)
0.956 0.044 0.000
F99-F99 Unspecified mental disorder
0.953 0.047 0.000
R19.4 Change in bowel habit
0.948 0.052 0.000
E11.2 With renal complications
0.945 0.055 0.000
R11 Nausea and vomiting
0.939 0.061 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.934 0.066 0.000
M65 Synovitis and tenosynovitis
0.930 0.070 0.000
M50-M54 Other dorsopathies
0.930 0.070 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.927 0.073 0.000
M48 Other spondylopathies
0.927 0.073 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.925 0.075 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.924 0.076 0.000
Chapter XX External causes of morbidity and mortality
0.921 0.079 0.000
F99 Mental disorder, not otherwise specified
0.920 0.080 0.000
E11.5 With peripheral circulatory complications
0.920 0.080 0.000
M47.8 Other spondylosis
0.907 0.093 0.000
M65.9 Synovitis and tenosynovitis, unspecified
0.907 0.093 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.905 0.095 0.000
F31 Bipolar affective disorder
0.905 0.095 0.000
F17 Mental and behavioural disorders due to use of tobacco
0.903 0.097 0.000
F17.2 Dependence syndrome
0.898 0.102 0.000
M05-M14 Inflammatory polyarthropathies
0.896 0.104 0.000
R19.8 Other specified symptoms and signs involving the digestive system and abdomen
0.890 0.110 0.000
M51 Other intervertebral disk disorders
0.890 0.110 0.000
M21.3 Wrist or foot drop (acquired)
0.890 0.110 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.890 0.110 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.889 0.111 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.889 0.111 0.000
M48.0 Spinal stenosis
0.886 0.114 0.000
F32 Depressive episode
0.886 0.114 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.885 0.115 0.000
E23 Hypofunction and other disorders of pituitary gland
0.878 0.122 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.877 0.123 0.000
T79-T79 Certain early complications of trauma
0.875 0.125 0.000
E27 Other disorders of adrenal gland
0.874 0.126 0.000
R60 Oedema, not elsewhere classified
0.874 0.126 0.000
R59 Enlarged lymph nodes
0.872 0.128 0.000
M65.96 Synovitis and tenosynovitis, unspecified (Lower leg)
0.871 0.129 0.000
E16 Other disorders of pancreatic internal secretion
0.871 0.129 0.000
R19.0 Intra-abdominal and pelvic swelling, mass and lump
0.870 0.130 0.000
E10.9 Without complications
0.864 0.136 0.000
M06 Other rheumatoid arthritis
0.864 0.136 0.000
M47.2 Other spondylosis with radiculopathy
0.864 0.136 0.000
M51.2 Other specified intervertebral disk displacement
0.860 0.140 0.000
R15 Faecal incontinence
0.859 0.141 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.858 0.142 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.857 0.143 0.000
E10.1 With ketoacidosis
0.855 0.145 0.000
G20-G26 Extrapyramidal and movement disorders
0.852 0.148 0.000
M24 Other specific joint derangements
0.849 0.151 0.000
F80-F89 Disorders of psychological development
0.847 0.153 0.000
M48.06 Spinal stenosis (Lumbar region)
0.847 0.153 0.000
E10.4 With neurological complications
0.845 0.155 0.000
S50-S59 Injuries to the elbow and forearm
0.840 0.160 0.000
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts
0.838 0.162 0.000
M23 Internal derangement of knee
0.836 0.164 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.835 0.165 0.000
E16.2 Hypoglycaemia, unspecified
0.833 0.167 0.000
M22 Disorders of patella
0.831 0.169 0.000
M47.82 Other spondylosis (Cervical region)
0.831 0.169 0.000
M21.37 Wrist or foot drop (acquired) (Ankle and foot)
0.830 0.170 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.830 0.170 0.000
M47.9 Spondylosis, unspecified
0.825 0.175 0.000
T66-T78 Other and unspecified effects of external causes
0.822 0.178 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.822 0.178 0.000
E24 Cushing's syndrome
0.818 0.182 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.813 0.187 0.000
T31 Burns classified according to extent of body surface involved
0.813 0.187 0.000
G59 Mononeuropathy in diseases classified elsewhere
0.813 0.187 0.000
F39 Unspecified mood [affective] disorder
0.812 0.188 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.811 0.189 0.000
M20.3 Other deformity of hallux (acquired)
0.810 0.190 0.000
F30 Manic episode
0.810 0.190 0.000
R29 Other symptoms and signs involving the nervous and musculoskeletal systems
0.807 0.193 0.000
M60-M63 Disorders of muscles
0.805 0.195 0.000
E22 Hyperfunction of pituitary gland
0.804 0.196 0.000
G20 Parkinson's disease
0.800 0.200 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.800 0.200 0.000
E11.1 With ketoacidosis
0.799 0.201 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.799 0.201 0.000
R63 Symptoms and signs concerning food and fluid intake
0.798 0.202 0.000
T83.1 Mechanical complication of other urinary devices and implants
0.797 0.203 0.000
R18 Ascites
0.797 0.203 0.000
M65.91 Synovitis and tenosynovitis, unspecified (Shoulder region)
0.796 0.204 0.000
M21.4 Flat foot [pes planus] (acquired)
0.795 0.205 0.000
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot
0.794 0.206 0.000
M06.9 Rheumatoid arthritis, unspecified
0.794 0.206 0.000
M32 Systemic lupus erythematosus
0.792 0.208 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.791 0.209 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.789 0.211 0.000
S90-S99 Injuries to the ankle and foot
0.788 0.212 0.000
T79 Certain early complications of trauma, not elsewhere classified
0.787 0.213 0.000
M21.2 Flexion deformity
0.787 0.213 0.000
S70-S79 Injuries to the hip and thigh
0.787 0.213 0.000
M23.8 Other internal derangements of knee
0.785 0.215 0.000
M91-M94 Chondropathies
0.785 0.215 0.000
T23 Burn and corrosion of wrist and hand
0.785 0.215 0.000
T20 Burn and corrosion of head and neck
0.785 0.215 0.000
M67 Other disorders of synovium and tendon
0.783 0.217 0.000
F31.9 Bipolar affective disorder, unspecified
0.783 0.217 0.000
R29.6 Tendency to fall, not elsewhere classified
0.781 0.219 0.000
T43.2 Other and unspecified antidepressants
0.780 0.220 0.000
E11.8 With unspecified complications
0.777 0.223 0.000
T39.1 4-Aminophenol derivatives
0.773 0.227 0.000
S40-S49 Injuries to the shoulder and upper arm
0.772 0.228 0.000
M25 Other joint disorders, not elsewhere classified
0.771 0.229 0.000
R64 Cachexia
0.769 0.231 0.000
E23.6 Other disorders of pituitary gland
0.769 0.231 0.000
M70-M79 Other soft tissue disorders
0.769 0.231 0.000
M21.1 Varus deformity, not elsewhere classified
0.765 0.235 0.000
F33 Recurrent depressive disorder
0.765 0.235 0.000
M15-M19 Arthrosis
0.764 0.236 0.000
S52 Fracture of forearm
0.762 0.238 0.000
M47.97 Spondylosis, unspecified (Lumbosacral region)
0.762 0.238 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.761 0.239 0.000
R60.0 Localised oedema
0.761 0.239 0.000
M47.26 Other spondylosis with radiculopathy (Lumbar region)
0.761 0.239 0.000
F32.0 Mild depressive episode
0.761 0.239 0.000
R26 Abnormalities of gait and mobility
0.758 0.242 0.000
G59.0 Diabetic mononeuropathy
0.758 0.242 0.000
T31.0 Burns involving less than 10% of body surface
0.758 0.242 0.000
Chapter XXII Codes for special purposes
0.757 0.242 0.000
M35 Other systemic involvement of connective tissue
0.757 0.243 0.000
M66 Spontaneous rupture of synovium and tendon
0.755 0.245 0.000
E11.6 With other specified complications
0.754 0.246 0.000
R63.4 Abnormal weight loss
0.753 0.247 0.000
F32.1 Moderate depressive episode
0.753 0.247 0.000
F32.2 Severe depressive episode without psychotic symptoms
0.753 0.247 0.000
E20 Hypoparathyroidism
0.751 0.249 0.000
R12 Heartburn
0.750 0.250 0.000
M51.9 Intervertebral disk disorder, unspecified
0.748 0.252 0.000
R59.9 Enlarged lymph nodes, unspecified
0.746 0.254 0.000
G12 Spinal muscular atrophy and related syndromes
0.746 0.254 0.000
R68 Other general symptoms and signs
0.743 0.257 0.000
M00-M03 Infectious arthropathies
0.742 0.258 0.000
R59.1 Generalised enlarged lymph nodes
0.742 0.258 0.000
Chapter I Certain infectious and parasitic diseases
0.741 0.259 0.000
M54 Dorsalgia
0.741 0.259 0.000
E10.2 With renal complications
0.739 0.261 0.000
M65.8 Other synovitis and tenosynovitis
0.739 0.261 0.000
F11 Mental and behavioural disorders due to use of opioids
0.738 0.262 0.000
E10.5 With peripheral circulatory complications
0.738 0.262 0.000
W20-W49 Exposure to inanimate mechanical forces
0.736 0.264 0.000
G63.2 Diabetic polyneuropathy
0.736 0.264 0.000
T22 Burn and corrosion of shoulder and upper limb, except wrist and hand
0.735 0.265 0.000
Y83 Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.734 0.266 0.000
M06.4 Inflammatory polyarthropathy
0.733 0.267 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.733 0.267 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.731 0.269 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.727 0.273 0.000
R52 Pain, not elsewhere classified
0.727 0.273 0.000
E27.9 Disorder of adrenal gland, unspecified
0.726 0.274 0.000
S10-S19 Injuries to the neck
0.725 0.275 0.000
W00-W19 Falls
0.724 0.276 0.000
T43.3 Phenothiazine antipsychotics and neuroleptics
0.722 0.278 0.000
M47.86 Other spondylosis (Lumbar region)
0.722 0.278 0.000
E40-E46 Malnutrition
0.722 0.278 0.000
Y86 Sequelae of other accidents
0.721 0.279 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.721 0.279 0.000
M46 Other inflammatory spondylopathies
0.719 0.281 0.000
Chapter XIV Diseases of the genitourinary system
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
E12 Malnutrition-related diabetes mellitus
0.717 0.283 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.716 0.283 0.000
M33 Dermatopolymyositis
0.716 0.283 0.000
M30 Polyarteritis nodosa and related conditions
0.716 0.283 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.716 0.284 0.000
F70-F79 Mental retardation
0.716 0.284 0.000
E11.7 With multiple complications
0.716 0.284 0.000
E11.0 With coma
0.716 0.284 0.000
T33-T35 Frostbite
0.715 0.284 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.715 0.284 0.000
T00-T07 Injuries involving multiple body regions
0.715 0.284 0.000
E23.2 Diabetes insipidus
0.713 0.287 0.000
S80-S89 Injuries to the knee and lower leg
0.712 0.288 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.711 0.289 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.711 0.289 0.000
M49 Spondylopathies in diseases classified elsewhere
0.711 0.289 0.000
E24.9 Cushing's syndrome, unspecified
0.709 0.291 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.709 0.291 0.000
F60-F69 Disorders of adult personality and behaviour
0.709 0.291 0.000
R65 Systemic Inflammatory Response Syndrome [SIRS]
0.708 0.291 0.000
R62 Lack of expected normal physiological development
0.708 0.291 0.000
R58 Haemorrhage, not elsewhere classified
0.708 0.291 0.000
E28 Ovarian dysfunction
0.708 0.292 0.000
T84.0 Mechanical complication of internal joint prosthesis
0.707 0.293 0.000
F38 Other mood [affective] disorders
0.707 0.293 0.000
F34 Persistent mood [affective] disorders
0.707 0.293 0.000
G54 Nerve root and plexus disorders
0.707 0.293 0.000
M06.0 Seronegative rheumatoid arthritis
0.706 0.294 0.000
M11 Other crystal arthropathies
0.706 0.294 0.000
N30-N39 Other diseases of urinary system
0.706 0.294 0.000
M16 Coxarthrosis [arthrosis of hip]
0.705 0.295 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.705 0.295 0.000
E13 Other specified diabetes mellitus
0.702 0.298 0.000
Y83.1 Surgical operation with implant of artificial internal device
0.702 0.298 0.000
G40-G47 Episodic and paroxysmal disorders
0.702 0.298 0.000
F81 Specific developmental disorders of scholastic skills
0.701 0.299 0.000
X50-X57 Overexertion, travel and privation
0.701 0.299 0.000
Y00-Y09 Assault
0.700 0.299 0.000
F31.2 Bipolar affective disorder, current episode manic with psychotic symptoms
0.700 0.300 0.000
F31.6 Bipolar affective disorder, current episode mixed
0.700 0.300 0.000
T79.3 Post-traumatic wound infection, not elsewhere classified
0.700 0.300 0.000
M48.02 Spinal stenosis (Cervical region)
0.699 0.300 0.000
M21.0 Valgus deformity, not elsewhere classified
0.699 0.301 0.000
T92 Sequelae of injuries of upper limb
0.699 0.301 0.000
M21.9 Acquired deformity of limb, unspecified
0.698 0.302 0.000
M21.8 Other specified acquired deformities of limbs
0.698 0.302 0.000
M21.7 Unequal limb length (acquired)
0.698 0.302 0.000
E10.8 With unspecified complications
0.698 0.302 0.000
E10.7 With multiple complications
0.698 0.302 0.000
E10.6 With other specified complications
0.698 0.302 0.000
E10.0 With coma
0.698 0.302 0.000
M65.93 Synovitis and tenosynovitis, unspecified (Forearm)
0.698 0.302 0.000
M21.6 Other acquired deformities of ankle and foot
0.696 0.303 0.000
M86-M90 Other osteopathies
0.696 0.303 0.000
S52.5 Fracture of lower end of radius
0.696 0.304 0.000
M47.0 Anterior spinal and vertebral artery compression syndromes
0.696 0.304 0.000
Chapter VIII Diseases of the ear and mastoid process
0.696 0.304 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.696 0.304 0.000
E34 Other endocrine disorders
0.696 0.304 0.000
E32 Diseases of thymus
0.696 0.304 0.000
E31 Polyglandular dysfunction
0.696 0.304 0.000
E30 Disorders of puberty, not elsewhere classified
0.696 0.304 0.000
E26 Hyperaldosteronism
0.696 0.304 0.000
E25 Adrenogenital disorders
0.696 0.304 0.000
M24.1 Other articular cartilage disorders
0.696 0.304 0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.696 0.304 0.000
T78 Adverse effects, not elsewhere classified
0.696 0.304 0.000
F31.3 Bipolar affective disorder, current episode mild or moderate depression
0.695 0.304 0.000
M54.1 Radiculopathy
0.695 0.305 0.000
R19.6 Halitosis
0.695 0.305 0.000
R19.3 Abdominal rigidity
0.695 0.305 0.000
R19.2 Visible peristalsis
0.695 0.305 0.000
R19.1 Abnormal bowel sounds
0.695 0.305 0.000
M47.90 Spondylosis, unspecified (Multiple sites in spine)
0.691 0.309 0.000
F31.0 Bipolar affective disorder, current episode hypomanic
0.690 0.310 0.000
A30-A49 Other bacterial diseases
0.690 0.310 0.000
S52.1 Fracture of upper end of radius
0.689 0.311 0.000
M47.27 Other spondylosis with radiculopathy (Lumbosacral region)
0.688 0.312 0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.687 0.313 0.000
M25.7 Osteophyte
0.685 0.315 0.000
M80-M85 Disorders of bone density and structure
0.684 0.316 0.000
M14 Arthropathies in other diseases classified elsewhere
0.684 0.316 0.000
T43.0 Tricyclic and tetracyclic antidepressants
0.683 0.317 0.000
M47.87 Other spondylosis (Lumbosacral region)
0.683 0.317 0.000
M48.07 Spinal stenosis (Lumbosacral region)
0.682 0.317 0.000
N32 Other disorders of bladder
0.682 0.318 0.000
M53 Other dorsopathies, not elsewhere classified
0.680 0.320 0.000
M20.2 Hallux rigidus
0.679 0.321 0.000
M22.3 Other derangements of patella
0.679 0.321 0.000
E22.0 Acromegaly and pituitary gigantism
0.679 0.321 0.000
G60 Hereditary and idiopathic neuropathy
0.678 0.322 0.000
E65-E68 Obesity and other hyperalimentation
0.677 0.323 0.000
M48.00 Spinal stenosis (Multiple sites in spine)
0.676 0.323 0.000
M20.0 Deformity of finger(s)
0.676 0.324 0.000
G62 Other polyneuropathies
0.676 0.324 0.000
T84.4 Mechanical complication of other internal orthopaedic devices, imnplants and grafts
0.675 0.324 0.000
M22.8 Other disorders of patella
0.675 0.325 0.000
G58 Other mononeuropathies
0.675 0.325 0.000
V40-V49 Car occupant injured in transport accident
0.674 0.326 0.000
E27.1 Primary adrenocortical insufficiency
0.674 0.326 0.000
M16.1 Other primary coxarthrosis
0.673 0.327 0.000
Y83.9 Surgical procedure, unspecified
0.673 0.327 0.000
R16 Hepatomegaly and splenomegaly, not elsewhere classified
0.671 0.329 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.670 0.329 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.670 0.329 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.670 0.330 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.670 0.330 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.670 0.330 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.670 0.330 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.670 0.330 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.670 0.330 0.000
T36 Poisoning by systemic antibiotics
0.670 0.330 0.000
F84 Pervasive developmental disorders
0.669 0.331 0.000
M31 Other necrotising vasculopathies
0.668 0.332 0.000
E50-E64 Other nutritional deficiencies
0.667 0.332 0.000
M21.47 Flat foot [pes planus] (acquired)-Ankle/foot
0.668 0.332 0.000
G57 Mononeuropathies of lower limb
0.667 0.333 0.000
M65.2 Calcific tendinitis
0.667 0.333 0.000
M65.1 Other infective (teno)synovitis
0.667 0.333 0.000
M65.0 Abscess of tendon sheath
0.667 0.333 0.000
N00-N08 Glomerular diseases
0.667 0.333 0.000
M23.89 Other internal derangements of knee (Unspecified ligament or Unspecified meniscus)
0.666 0.334 0.000
N32.0 Bladder-neck obstruction
0.666 0.334 0.000
M23.83 Other internal derangements of knee (Medial collateral ligament or Other and unspecified medial meniscus)
0.665 0.335 0.000
G12.2 Motor neuron disease
0.665 0.335 0.000
F19 Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances
0.665 0.335 0.000
F18 Mental and behavioural disorders due to use of volatile solvents
0.665 0.335 0.000
F16 Mental and behavioural disorders due to use of hallucinogens
0.665 0.335 0.000
F15 Mental and behavioural disorders due to use of other stimulants, including caffeine
0.665 0.335 0.000
F14 Mental and behavioural disorders due to use of cocaine
0.665 0.335 0.000
F13 Mental and behavioural disorders due to use of sedatives or hypnotics
0.665 0.335 0.000
F12 Mental and behavioural disorders due to use of cannabinoids
0.665 0.335 0.000
M47.96 Spondylosis, unspecified (Lumbar region)
0.665 0.335 0.000
M62 Other disorders of muscle
0.665 0.335 0.000
M21.57 Acquired clawhand, clubhand, clawfoot and clubfoot (Ankle and foot)
0.665 0.335 0.000
M48.9 Spondylopathy, unspecified
0.664 0.336 0.000
M48.8 Other specified spondylopathies
0.664 0.336 0.000
M48.4 Fatigue fracture of vertebra
0.664 0.336 0.000
M48.3 Traumatic spondylopathy
0.664 0.336 0.000
M48.2 Kissing spine
0.664 0.336 0.000
M48.1 Ankylosing hyperostosis [Forestier]
0.664 0.336 0.000
R60.1 Generalised oedema
0.664 0.336 0.000
R51 Headache
0.663 0.337 0.000
E15 Nondiabetic hypoglycaemic coma
0.663 0.337 0.000
G70-G73 Diseases of myoneural junction and muscle
0.662 0.337 0.000
T25 Burn and corrosion of ankle and foot
0.662 0.338 0.000
T24 Burn and corrosion of hip and lower limb, except ankle and foot
0.662 0.338 0.000
T21 Burn and corrosion of trunk
0.662 0.338 0.000
M47.1 Other spondylosis with myelopathy
0.662 0.338 0.000
M54.16 Radiculopathy (Lumbar region)
0.662 0.338 0.000
T83.8 Other complications of genito-urinary prosthetic devices, implants and grafts
0.662 0.338 0.000
R60.9 Oedema, unspecified
0.662 0.338 0.000
G37 Other demyelinating diseases of central nervous system
0.661 0.339 0.000
M24.0 Loose body in joint
0.661 0.339 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.661 0.339 0.000
A41 Other septicaemia
0.661 0.339 0.000
M47.89 Other spondylosis (Site unspecified)
0.661 0.339 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.660 0.339 0.000
Y35-Y36 Legal intervention and operations of war
0.660 0.339 0.000
Y10-Y34 Event of undetermined intent
0.660 0.339 0.000
X85-X99 Assault
0.660 0.339 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.660 0.339 0.000
X30-X39 Exposure to forces of nature
0.660 0.339 0.000
X10-X19 Contact with heat and hot substances
0.660 0.339 0.000
X00-X09 Exposure to smoke, fire and flames
0.660 0.339 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.660 0.339 0.000
W75-W84 Other accidental threats to breathing
0.660 0.339 0.000
W65-W74 Accidental drowning and submersion
0.660 0.339 0.000
W50-W64 Exposure to animate mechanical forces
0.660 0.339 0.000
V98-V99 Other and unspecified transport accidents
0.660 0.339 0.000
V95-V97 Air and space transport accidents
0.660 0.339 0.000
V90-V94 Water transport accidents
0.660 0.339 0.000
V70-V79 Bus occupant injured in transport accident
0.660 0.339 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.660 0.339 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.660 0.339 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.660 0.339 0.000
V01-V09 Pedestrian injured in transport accident
0.660 0.339 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.660 0.340 0.000
R57 Shock, not elsewhere classified
0.659 0.341 0.000
G50 Disorders of trigeminal nerve
0.658 0.342 0.000
M47.80 Other spondylosis (Multiple sites in spine)
0.658 0.342 0.000
M20.6 Acquired deformity of toe(s), unspecified
0.658 0.342 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.657 0.343 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.656 0.344 0.000
M34 Systemic sclerosis
0.656 0.344 0.000
G11 Hereditary ataxia
0.656 0.344 0.000
E10.3 With ophthalmic complications
0.655 0.345 0.000
N30 Cystitis
0.655 0.345 0.000
F33.9 Recurrent depressive disorder, unspecified
0.654 0.346 0.000
T86 Failure and rejection of transplanted organs and tissues
0.653 0.347 0.000
T23.3 Burn of third degree of wrist and hand
0.652 0.348 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.651 0.349 0.000
E23.0 Hypopituitarism
0.651 0.349 0.000
V80-V89 Other land transport accidents
0.651 0.349 0.000
M47.88 Other spondylosis (Sacral and sacrococcygeal region)
0.651 0.349 0.000
M47.85 Other spondylosis (Thoracolumbar region)
0.651 0.349 0.000
M47.84 Other spondylosis (Thoracic region)
0.651 0.349 0.000
M47.83 Other spondylosis (Cervicothoracic region)
0.651 0.349 0.000
M47.81 Other spondylosis (Occipito-atlanto-axial region)
0.651 0.349 0.000
M65.99 Synovitis and tenosynovitis, unspecified (Site unspecified)
0.650 0.349 0.000
M65.98 Synovitis and tenosynovitis, unspecified (Other)
0.650 0.349 0.000
M65.95 Synovitis and tenosynovitis, unspecified (Pelvic region and thigh)
0.650 0.349 0.000
M65.92 Synovitis and tenosynovitis, unspecified (Upper arm)
0.650 0.349 0.000
M65.90 Synovitis and tenosynovitis, unspecified (Multiple sites)
0.650 0.349 0.000
M23.86 Other internal derangements of knee (Other and unspecified lateral meniscus)
0.649 0.351 0.000
F31.8 Other bipolar affective disorders
0.649 0.351 0.000
F31.7 Bipolar affective disorder, currently in remission
0.649 0.351 0.000
F31.5 Bipolar affective disorder, current episode severe depression with psychotic symptoms
0.649 0.351 0.000
F31.4 Bipolar affective disorder, current episode severe depression without psychotic symptoms
0.649 0.351 0.000
T83.4 Mechanical complication of other prosthetic devices, implants and grafts in genital tract
0.648 0.352 0.000
E29 Testicular dysfunction
0.647 0.353 0.000
F17.9 Unspecified mental and behavioural disorder
0.647 0.353 0.000
F17.8 Other mental and behavioural disorders
0.647 0.353 0.000
F17.7 Residual and late-onset psychotic disorder
0.647 0.353 0.000
F17.6 Amnesic syndrome
0.647 0.353 0.000
F17.5 Psychotic disorder
0.647 0.353 0.000
F17.4 Withdrawal state with delirium
0.647 0.353 0.000
F17.3 Withdrawal state
0.647 0.353 0.000
F17.0 Acute intoxication
0.647 0.353 0.000
M40-M43 Deforming dorsopathies
0.647 0.353 0.000
F30.9 Manic episode, unspecified
0.646 0.354 0.000
T20.2 Burn of second degree of head and neck
0.645 0.355 0.000
M24.2 Disorder of ligament
0.645 0.355 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.644 0.356 0.000
M32.1 Systemic lupus erythematosus with organ or system involvement
0.643 0.357 0.000
M12 Other specific arthropathies
0.643 0.357 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.643 0.357 0.000
M08 Juvenile arthritis
0.643 0.357 0.000
M65.94 Synovitis and tenosynovitis, unspecified (Hand)
0.642 0.357 0.000
S92 Fracture of foot, except ankle
0.642 0.358 0.000
M22.4 Chondromalacia patellae
0.640 0.360 0.000
M19 Other arthrosis
0.639 0.361 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.638 0.361 0.000
X20-X29 Contact with venomous animals and plants
0.638 0.361 0.000
T87 Complications peculiar to reattachment and amputation
0.638 0.362 0.000
M51.3 Other specified intervertebral disk degeneration
0.638 0.362 0.000
M51.1 Lumbar and other intervertebral disk disorders with radiculopathy
0.638 0.362 0.000
M51.4 Schmorl's nodes
0.638 0.362 0.000
M21.39 Wrist or foot drop (acquired)-Site unspec
0.638 0.362 0.000
M21.38 Wrist or foot drop (acquired)-Other
0.638 0.362 0.000
M21.36 Wrist or foot drop (acquired)-Lower leg
0.638 0.362 0.000
M21.35 Wrist or foot drop (acquired)-Pelvic/thigh
0.638 0.362 0.000
M21.34 Wrist or foot drop (acquired) (Hand)
0.638 0.362 0.000
M21.33 Wrist or foot drop (acquired) (Forearm)
0.638 0.362 0.000
M21.32 Wrist or foot drop (acquired)-Upper arm
0.638 0.362 0.000
M21.31 Wrist or foot drop (acquired)-Shldr region
0.638 0.362 0.000
M21.30 Wrist or foot drop (acquired) (Multiple sites)
0.638 0.362 0.000
T32 Corrosions classified according to extent of body surface involved
0.638 0.362 0.000
T30 Burn and corrosion, body region unspecified
0.638 0.362 0.000
T29 Burns and corrosions of multiple body regions
0.638 0.362 0.000
G53 Cranial nerve disorders in diseases classified elsewhere
0.638 0.362 0.000
G52 Disorders of other cranial nerves
0.638 0.362 0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.638 0.362 0.000
G64 Other disorders of peripheral nervous system
0.637 0.363 0.000
E27.8 Other specified disorders of adrenal gland
0.637 0.363 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.637 0.363 0.000
B15-B19 Viral hepatitis
0.637 0.363 0.000
M21.24 Flexion deformity (Hand)
0.637 0.363 0.000
A41.9 Septicaemia, unspecified
0.636 0.364 0.000
S52.10 Fracture of upper end of radius (closed)
0.636 0.364 0.000
M48.08 Spinal stenosis (Sacral and sacrococcygeal region)
0.636 0.364 0.000
M48.05 Spinal stenosis (Thoracolumbar region)
0.636 0.364 0.000
M48.04 Spinal stenosis (Thoracic region)
0.636 0.364 0.000
M48.03 Spinal stenosis (Cervicothoracic region)
0.636 0.364 0.000
M48.01 Spinal stenosis (Occipito-atlanto-axial region)
0.636 0.364 0.000
G56 Mononeuropathies of upper limb
0.636 0.364 0.000
M23.9 Internal derangement of knee, unspecified
0.635 0.364 0.000
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.635 0.365 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.635 0.365 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.635 0.365 0.000
F32.8 Other depressive episodes
0.635 0.365 0.000
M23.4 Loose body in knee
0.635 0.365 0.000
G05 Encephalitis, myelitis and encephalomyelitis in diseases classified elsewhere
0.635 0.365 0.000
E14 Unspecified diabetes mellitus
0.634 0.366 0.000
F30.0 Hypomania
0.632 0.368 0.000
V10-V19 Pedal cyclist injured in transport accident
0.632 0.368 0.000
E23.7 Disorder of pituitary gland, unspecified
0.629 0.370 0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.629 0.370 0.000
E23.1 Drug-induced hypopituitarism
0.629 0.370 0.000
T78.2 Anaphylactic shock, unspecified
0.629 0.371 0.000
T43.9 Psychotropic drug, unspecified
0.628 0.371 0.000
T43.8 Other psychotropic drugs, not elsewhere classified
0.628 0.371 0.000
T43.6 Psychostimulants with abuse potential
0.628 0.371 0.000
T43.4 Butyrophenone and thioxanthene neuroleptics
0.628 0.371 0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.628 0.371 0.000
R61 Hyperhidrosis
0.628 0.372 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.628 0.372 0.000
T84.2 Mechanical complication of internal fixation device of other bones
0.628 0.372 0.000
T90 Sequelae of injuries of head
0.627 0.373 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.627 0.373 0.000
E27.5 Adrenomedullary hyperfunction
0.627 0.373 0.000
E27.3 Drug-induced adrenocortical insufficiency
0.627 0.373 0.000
E27.2 Addisonian crisis
0.627 0.373 0.000
E27.0 Other adrenocortical overactivity
0.627 0.373 0.000
M25.77 Osteophyte (Ankle and foot)
0.627 0.373 0.000
T20.1 Burn of first degree of head and neck
0.626 0.373 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.626 0.374 0.000
M48.5 Collapsed vertebra, not elsewhere classified
0.626 0.374 0.000
M25.3 Other instability of joint
0.625 0.375 0.000
T79.8 Other early complications of trauma
0.625 0.375 0.000
E16.9 Disorder of pancreatic internal secretion, unspecified
0.624 0.375 0.000
E16.8 Other specified disorders of pancreatic internal secretion
0.624 0.375 0.000
E16.4 Abnormal secretion of gastrin
0.624 0.375 0.000
E16.3 Increased secretion of glucagon
0.624 0.375 0.000
E16.1 Other hypoglycaemia
0.624 0.375 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.624 0.375 0.000
U82-U85 Resistance to antimicrobial and antineoplastic drugs
0.624 0.375 0.000
F31.1 Bipolar affective disorder, current episode manic without psychotic symptoms
0.623 0.377 0.000
E11.3 With ophthalmic complications
0.623 0.377 0.000
M06.3 Rheumatoid nodule
0.622 0.377 0.000
R63.3 Feeding difficulties and mismanagement
0.621 0.379 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.620 0.380 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.620 0.380 0.000
S52.50 Fracture of lower end of radius (closed)
0.620 0.380 0.000
S41 Open wound of shoulder and upper arm
0.619 0.380 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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