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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2156875
log Bayes Factor = 144.18
Chromosome 6   position 31,317,347  (GRCh37) Explore rs2156875 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
1.000 0.000 0.000
L40.5 Arthropathic psoriasis
1.000 0.000 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
L40 Psoriasis
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
M45.X9 Ankylosing spondylitis (Site unspecified)
1.000 0.000 0.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
Z95 Presence of cardiac and vascular implants and grafts
0.000 0.000 1.000
E10.1 With ketoacidosis
0.000 0.001 0.999
Z95.1 Presence of aortocoronary bypass graft
0.000 0.001 0.999
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.001 0.999
E14.9 Without complications
0.000 0.003 0.997
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.003 0.997
Z95.8 Presence of other cardiac and vascular implants and grafts
0.000 0.003 0.997
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.004 0.996
L40.0 Psoriasis vulgaris
0.996 0.004 0.000
Z95.0 Presence of cardiac pacemaker
0.000 0.007 0.993
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.009 0.991
M07.3 Other psoriatic arthropathies
0.989 0.011 0.000
M07.39 Other psoriatic arthropathies (Site unspecified)
0.989 0.011 0.000
E16 Other disorders of pancreatic internal secretion
0.000 0.015 0.985
E10.4 With neurological complications
0.000 0.017 0.983
E83.1 Disorders of iron metabolism
0.982 0.018 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.021 0.979
M07.30 Other psoriatic arthropathies (Multiple sites)
0.978 0.022 0.000
E16.2 Hypoglycaemia, unspecified
0.000 0.024 0.976
E20-E35 Disorders of other endocrine glands
0.000 0.027 0.973
M06 Other rheumatoid arthritis
0.000 0.035 0.965
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.055 0.945
M45 Ankylosing spondylitis
0.942 0.058 0.000
E28 Ovarian dysfunction
0.000 0.061 0.939
Z95.5 Presence of coronary angioplasty implant and graft
0.000 0.061 0.939
E10.0 With coma
0.000 0.064 0.936
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.070 0.930
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.926 0.074 0.000
M06.3 Rheumatoid nodule
0.000 0.074 0.926
Z95.3 Presence of xenogenic heart valve
0.000 0.075 0.925
E07 Other disorders of thyroid
0.000 0.081 0.919
E28.2 Polycystic ovarian syndrome
0.000 0.085 0.915
E10.5 With peripheral circulatory complications
0.000 0.086 0.914
E10.2 With renal complications
0.000 0.095 0.905
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.890 0.110 0.000
M05-M14 Inflammatory polyarthropathies
0.003 0.111 0.886
E21.3 Hyperparathyroidism, unspecified
0.000 0.116 0.884
I25 Chronic ischaemic heart disease
0.000 0.116 0.884
E14.8 With unspecified complications
0.000 0.117 0.883
I25.1 Atherosclerotic heart disease
0.000 0.118 0.882
I20.9 Angina pectoris, unspecified
0.000 0.120 0.880
M05 Seropositive rheumatoid arthritis
0.001 0.121 0.878
M06.34 Rheumatoid nodule (Hand)
0.000 0.127 0.873
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.127 0.873
E14.3 With ophthalmic complications
0.000 0.127 0.873
I20-I25 Ischaemic heart diseases
0.000 0.129 0.871
I20 Angina pectoris
0.000 0.129 0.871
M07.34 Other psoriatic arthropathies (Hand)
0.871 0.129 0.000
I25.2 Old myocardial infarction
0.000 0.134 0.866
E06 Thyroiditis
0.000 0.137 0.863
E07.9 Disorder of thyroid, unspecified
0.000 0.138 0.862
M35.3 Polymyalgia rheumatica
0.000 0.139 0.861
M35 Other systemic involvement of connective tissue
0.000 0.139 0.861
M35.0 Sicca syndrome [Sjogren]
0.000 0.142 0.858
E14.6 With other specified complications
0.000 0.147 0.853
E40-E46 Malnutrition
0.000 0.149 0.851
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.150 0.850
E27 Other disorders of adrenal gland
0.000 0.152 0.848
E14.1 With ketoacidosis
0.000 0.153 0.847
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.161 0.839
I22 Subsequent myocardial infarction
0.000 0.162 0.838
L40.8 Other psoriasis
0.838 0.162 0.000
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.166 0.834
E10.6 With other specified complications
0.000 0.171 0.829
E70-E90 Metabolic disorders
0.000 0.171 0.829
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.173 0.827
M07.38 Other psoriatic arthropathies (Other)
0.823 0.177 0.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.178 0.822
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.178 0.822
E27.1 Primary adrenocortical insufficiency
0.000 0.182 0.818
L40.1 Generalised pustular psoriasis
0.818 0.182 0.000
E16.1 Other hypoglycaemia
0.000 0.184 0.816
M35.1 Other overlap syndromes
0.000 0.189 0.811
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.191 0.809
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.192 0.808
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.805 0.194 0.000
E13 Other specified diabetes mellitus
0.000 0.195 0.805
I25.5 Ischaemic cardiomyopathy
0.000 0.196 0.804
E21.0 Primary hyperparathyroidism
0.000 0.207 0.793
L40.3 Pustulosis palmaris et plantaris
0.792 0.208 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.210 0.790
E14.5 With peripheral circulatory complications
0.000 0.213 0.787
M07 Psoriatic and enteropathic arthropathies
0.468 0.213 0.319
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.223 0.777
M07.31 Other psoriatic arthropathies (Shoulder region)
0.776 0.224 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.225 0.775
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.229 0.771
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.233 0.767
E14.2 Withrenal complications
0.000 0.233 0.767
L40.4 Guttate psoriasis
0.761 0.239 0.000
M06.8 Other specified rheumatoid arthritis
0.000 0.245 0.755
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.250 0.750
E06.3 Autoimmune thyroiditis
0.000 0.253 0.747
E89.0 Postprocedural hypothyroidism
0.000 0.255 0.745
E46 Unspecified protein-energy malnutrition
0.000 0.256 0.744
E10.8 With unspecified complications
0.000 0.264 0.736
M07.36 Other psoriatic arthropathies (Lower leg)
0.734 0.266 0.000
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.267 0.733
E10.7 With multiple complications
0.000 0.269 0.731
E22 Hyperfunction of pituitary gland
0.000 0.271 0.729
M11 Other crystal arthropathies
0.002 0.273 0.725
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.279 0.721
M45.X6 Ankylosing spondylitis (Lumbar region)
0.720 0.280 0.000
E14.0 With coma
0.000 0.281 0.719
E11 Non-insulin-dependent diabetes mellitus
0.000 0.282 0.718
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.717 0.283 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E78.0 Pure hypercholesterolaemia
0.000 0.284 0.716
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.289 0.711
E15 Nondiabetic hypoglycaemic coma
0.000 0.289 0.711
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.710 0.290 0.000
M07.33 Other psoriatic arthropathies (Forearm)
0.709 0.291 0.000
M07.32 Other psoriatic arthropathies (Upper arm)
0.709 0.291 0.000
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.292 0.708
E78.2 Mixed hyperlipidaemia
0.000 0.293 0.707
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.294 0.706
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.294 0.706
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.294 0.706
E16.4 Abnormal secretion of gastrin
0.000 0.294 0.706
E16.3 Increased secretion of glucagon
0.000 0.294 0.706
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.296 0.704
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.302 0.698
E32 Diseases of thymus
0.000 0.302 0.698
E30 Disorders of puberty, not elsewhere classified
0.000 0.302 0.698
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.303 0.697
E89.3 Postprocedural hypopituitarism
0.000 0.306 0.694
E31 Polyglandular dysfunction
0.000 0.308 0.692
M06.2 Rheumatoid bursitis
0.000 0.308 0.692
M06.1 Adult-onset Still's disease
0.000 0.308 0.692
I20.1 Angina pectoris with documented spasm
0.000 0.309 0.691
M05.8 Other seropositive rheumatoid arthritis
0.001 0.312 0.687
E21.4 Other specified disorders of parathyroid gland
0.000 0.317 0.683
M35.7 Hypermobility syndrome
0.000 0.317 0.683
K90 Intestinal malabsorption
0.000 0.319 0.681
E11.0 With coma
0.000 0.320 0.680
M35.2 Behcet's disease
0.000 0.321 0.679
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.675 0.324 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.675 0.324 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.675 0.324 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.675 0.324 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.675 0.324 0.000
M10 Gout
0.001 0.325 0.674
E28.3 Primary ovarian failure
0.000 0.325 0.675
E23 Hypofunction and other disorders of pituitary gland
0.000 0.326 0.674
E28.9 Ovarian dysfunction, unspecified
0.000 0.326 0.673
E28.8 Other ovarian dysfunction
0.000 0.326 0.673
E28.1 Androgen excess
0.000 0.326 0.673
E28.0 Oestrogen excess
0.000 0.326 0.673
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.331 0.669
E74 Other disorders of carbohydrate metabolism
0.000 0.333 0.667
E03.1 Congenital hypothyroidism without goitre
0.000 0.335 0.665
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.336 0.664
M06.38 Rheumatoid nodule (Other)
0.000 0.336 0.664
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.336 0.664
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.336 0.664
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.336 0.664
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.336 0.664
E05.8 Other thyrotoxicosis
0.000 0.337 0.663
E89.2 Postprocedural hypoparathyroidism
0.000 0.337 0.663
E78.4 Other hyperlipidaemia
0.000 0.340 0.660
E13.9 Without complications
0.000 0.340 0.660
E07.1 Dyshormogenetic goitre
0.000 0.341 0.659
E07.0 Hypersecretion of calcitonin
0.000 0.341 0.659
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.344 0.656
E07.8 Other specified disorders of thyroid
0.000 0.346 0.654
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.346 0.654
E06.9 Thyroiditis, unspecified
0.000 0.351 0.649
M45.X2 Ankylosing spondylitis (Cervical region)
0.648 0.352 0.000
E11.9 Without complications
0.000 0.352 0.648
E24 Cushing's syndrome
0.000 0.353 0.647
E73 Lactose intolerance
0.000 0.356 0.644
M06.4 Inflammatory polyarthropathy
0.000 0.358 0.642
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.359 0.641
I22.8 Subsequent myocardial infarction of other sites
0.000 0.359 0.641
E14.4 With neurological complications
0.000 0.360 0.640
M08 Juvenile arthritis
0.002 0.361 0.636
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.362 0.638
Z95.9 Presence of cardiac and vascular implant and graft, unspecified
0.000 0.362 0.638
M09 Juvenile arthritis in diseases classified elsewhere
0.003 0.362 0.635
E79 Disorders of purine and pyrimidine metabolism
0.000 0.363 0.637
E03.8 Other specified hypothyroidism
0.000 0.364 0.636
M12 Other specific arthropathies
0.002 0.365 0.633
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.001 0.369 0.629
M05.1 Rheumatoid lung disease
0.001 0.369 0.629
M05.0 Felty's syndrome
0.001 0.369 0.629
E20 Hypoparathyroidism
0.000 0.371 0.629
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.374 0.626
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.374 0.626
E06.5 Other chronic thyroiditis
0.000 0.375 0.625
E21.2 Other hyperparathyroidism
0.000 0.377 0.623
E06.4 Drug-induced thyroiditis
0.000 0.381 0.618
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.381 0.618
E06.1 Subacute thyroiditis
0.000 0.381 0.618
E06.0 Acute thyroiditis
0.000 0.381 0.618
M11.2 Other chondrocalcinosis
0.001 0.382 0.617
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.383 0.617
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.383 0.617
M35.5 Multifocal fibrosclerosis
0.000 0.383 0.617
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.383 0.617
I23 Certain current complications following acute myocardial infarction
0.000 0.384 0.616
M06.33 Rheumatoid nodule (Forearm)
0.000 0.389 0.610
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.390 0.610
E45 Retarded development following protein-energy malnutrition
0.000 0.390 0.610
E43 Unspecified severe protein-energy malnutrition
0.000 0.390 0.610
E42 Marasmic kwashiorkor
0.000 0.390 0.610
E41 Nutritional marasmus
0.000 0.390 0.610
E40 Kwashiorkor
0.000 0.390 0.610
E84 Cystic fibrosis
0.000 0.391 0.609
I25.4 Coronary artery aneurysm
0.000 0.391 0.609
E27.5 Adrenomedullary hyperfunction
0.000 0.392 0.608
E27.0 Other adrenocortical overactivity
0.000 0.392 0.608
E22.1 Hyperprolactinaemia
0.000 0.397 0.603
Z95.2 Presence of prosthetic heart valve
0.000 0.399 0.601
I25.6 Silent myocardial ischaemia
0.000 0.401 0.599
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.402 0.598
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.000 0.403 0.596
E26 Hyperaldosteronism
0.000 0.406 0.594
E77 Disorders of glycoprotein metabolism
0.000 0.406 0.594
E76 Disorders of glycosaminoglycan metabolism
0.000 0.406 0.594
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.406 0.594
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.406 0.594
E89.4 Postprocedural ovarian failure
0.000 0.406 0.594
E78.6 Lipoprotein deficiency
0.000 0.407 0.593
E23.2 Diabetes insipidus
0.000 0.409 0.591
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.412 0.588
E13.3 With ophthalmic complications
0.000 0.414 0.586
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.415 0.585
E88 Other metabolic disorders
0.000 0.420 0.580
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.420 0.580
E89.5 Postprocedural testicular hypofunction
0.000 0.420 0.580
E89.1 Postprocedural hypoinsulinaemia
0.000 0.420 0.580
M14 Arthropathies in other diseases classified elsewhere
0.002 0.420 0.577
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.420 0.580
E13.8 With unspecified complications
0.000 0.422 0.577
E13.7 With multiple complications
0.000 0.422 0.577
E13.6 With other specified complications
0.000 0.422 0.577
E13.5 With peripheral circulatory complications
0.000 0.422 0.577
E13.4 With neurological complications
0.000 0.422 0.577
E13.2 With renal complications
0.000 0.422 0.577
E13.1 With ketoacidosis
0.000 0.422 0.577
E13.0 With coma
0.000 0.422 0.577
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.423 0.577
E70 Disorders of aromatic amino-acid metabolism
0.000 0.430 0.570
E22.0 Acromegaly and pituitary gigantism
0.000 0.432 0.568
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.432 0.568
E27.9 Disorder of adrenal gland, unspecified
0.000 0.432 0.568
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.433 0.567
M07.5 Arthropathy in ulcerative colitis
0.336 0.436 0.229
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.336 0.436 0.229
M07.2 Psoriatic spondylitis
0.336 0.436 0.229
M07.1 Arthritis mutilans
0.336 0.436 0.229
M07.0 Distal interphalangeal psoriatic arthropathy
0.336 0.436 0.229
M11.26 Other chondrocalcinosis (Lower leg)
0.000 0.436 0.564
M07.6 Other enteropathic arthropathies
0.351 0.436 0.214
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.438 0.562
E23.6 Other disorders of pituitary gland
0.000 0.439 0.561
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.444 0.556
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.445 0.555
E11.1 With ketoacidosis
0.000 0.445 0.555
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.000 0.446 0.553
M05.80 Other seropositive rheumatoid arthritis (Multiple sites)
0.001 0.450 0.549
M05.2 Rheumatoid vasculitis
0.001 0.450 0.549
E25 Adrenogenital disorders
0.001 0.451 0.548
M35.8 Other specified systemic involvement of connective tissue
0.000 0.452 0.548
E78.3 Hyperchylomicronaemia
0.000 0.452 0.548
E34 Other endocrine disorders
0.000 0.453 0.547
E11.8 With unspecified complications
0.000 0.454 0.546
I20.0 Unstable angina
0.000 0.455 0.545
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.456 0.543
K90.9 Intestinal malabsorption, unspecified
0.000 0.457 0.543
E72 Other disorders of amino-acid metabolism
0.000 0.458 0.542
M06.88 Other specified rheumatoid arthritis (Other)
0.000 0.458 0.542
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.000 0.458 0.542
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.000 0.458 0.542
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.000 0.458 0.542
M06.84 Other specified rheumatoid arthritis (Hand)
0.000 0.458 0.542
M06.83 Other specified rheumatoid arthritis (Forearm)
0.000 0.458 0.542
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.000 0.458 0.542
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.000 0.458 0.542
M11.9 Crystal arthropathy, unspecified
0.001 0.467 0.532
K90.8 Other intestinal malabsorption
0.000 0.468 0.532
E50-E64 Other nutritional deficiencies
0.000 0.471 0.529
M10.0 Idiopathic gout
0.001 0.472 0.527
E29 Testicular dysfunction
0.000 0.475 0.525
E22.8 Other hyperfunction of pituitary gland
0.000 0.477 0.523
M11.1 Familial chondrocalcinosis
0.002 0.479 0.520
M11.0 Hydroxyapatite deposition disease
0.002 0.479 0.520
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.484 0.516
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.485 0.515
E11.7 With multiple complications
0.000 0.485 0.515
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E73.9 Lactose intolerance, unspecified
0.000 0.488 0.512
M10.9 Gout, unspecified
0.000 0.497 0.503
E30.9 Disorder of puberty, unspecified
0.000 0.499 0.500
E30.8 Other disorders of puberty
0.000 0.499 0.500
E30.1 Precocious puberty
0.000 0.499 0.500
E30.0 Delayed puberty
0.000 0.499 0.500
E32.9 Disease of thymus, unspecified
0.000 0.499 0.500
E32.8 Other diseases of thymus
0.000 0.499 0.500
E32.1 Abscess of thymus
0.000 0.499 0.500
E32.0 Persistent hyperplasia of thymus
0.000 0.499 0.500
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.499 0.500
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.499 0.500
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.499 0.500
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.501 0.499
E31.9 Polyglandular dysfunction, unspecified
0.000 0.504 0.496
E31.8 Other polyglandular dysfunction
0.000 0.504 0.496
E31.1 Polyglandular hyperfunction
0.000 0.504 0.496
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.504 0.496
M06.18 Adult-onset Still's disease (Other)
0.000 0.504 0.496
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.504 0.496
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.504 0.496
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.504 0.496
M06.14 Adult-onset Still's disease (Hand)
0.000 0.504 0.496
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.504 0.496
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.504 0.496
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.504 0.496
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.504 0.496
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.504 0.496
M06.28 Rheumatoid bursitis (Other)
0.000 0.504 0.496
M06.27 Rheumatoid bursitis (Ankle and foot)
0.000 0.504 0.496
M06.26 Rheumatoid bursitis (Lower leg)
0.000 0.504 0.496
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.000 0.504 0.496
M06.24 Rheumatoid bursitis (Hand)
0.000 0.504 0.496
M06.23 Rheumatoid bursitis (Forearm)
0.000 0.504 0.496
M06.22 Rheumatoid bursitis (Upper arm)
0.000 0.504 0.496
M06.21 Rheumatoid bursitis (Shoulder region)
0.000 0.504 0.496
M06.20 Rheumatoid bursitis (Multiple sites)
0.000 0.504 0.496
M11.8 Other specified crystal arthropathies
0.002 0.506 0.493
M05.89 Other seropositive rheumatoid arthritis (Site unspecified)
0.001 0.507 0.492
M05.88 Other seropositive rheumatoid arthritis (Other)
0.001 0.507 0.492
M05.87 Other seropositive rheumatoid arthritis (Ankle and foot)
0.001 0.507 0.492
M05.86 Other seropositive rheumatoid arthritis (Lower leg)
0.001 0.507 0.492
M05.85 Other seropositive rheumatoid arthritis (Pelvic region and thigh)
0.001 0.507 0.492
M05.84 Other seropositive rheumatoid arthritis (Hand)
0.001 0.507 0.492
M05.83 Other seropositive rheumatoid arthritis (Forearm)
0.001 0.507 0.492
M05.82 Other seropositive rheumatoid arthritis (Upper arm)
0.001 0.507 0.492
M05.81 Other seropositive rheumatoid arthritis (Shoulder region)
0.001 0.507 0.492
E31.0 Autoimmune polyglandular failure
0.000 0.510 0.490
I25.3 Aneurysm of heart
0.000 0.512 0.488
K90.3 Pancreatic steatorrhoea
0.000 0.512 0.488
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.512 0.488
K90.1 Tropical sprue
0.000 0.512 0.488
M10.4 Other secondary gout
0.001 0.516 0.483
M10.2 Drug-induced gout
0.001 0.516 0.483
M10.1 Lead-induced gout
0.001 0.516 0.483
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.517 0.483
E23.1 Drug-induced hypopituitarism
0.000 0.517 0.483
E24.2 Drug-induced Cushing's syndrome
0.000 0.518 0.482
M08.0 Juvenile rheumatoid arthritis
0.002 0.520 0.478
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.521 0.478
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.521 0.478
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.521 0.478
E74.2 Disorders of galactose metabolism
0.000 0.521 0.478
E74.1 Disorders of fructose metabolism
0.000 0.521 0.478
M12.3 Palindromic rheumatism
0.002 0.523 0.476
Z95.4 Presence of other heart-valve replacement
0.000 0.523 0.477
I23.8 Other current complications following acute myocardial infarction
0.000 0.525 0.475
E11.6 With other specified complications
0.000 0.525 0.475
E78.1 Pure hyperglyceridaemia
0.000 0.528 0.472
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.536 0.464
E24.3 Ectopic ACTH syndrome
0.000 0.536 0.464
E24.1 Nelson's syndrome
0.000 0.536 0.464
E73.8 Other lactose intolerance
0.000 0.538 0.462
E73.1 Secondary lactase deficiency
0.000 0.538 0.462
E73.0 Congenital lactase deficiency
0.000 0.538 0.462
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.540 0.460
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.540 0.460
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.540 0.460
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.540 0.460
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.540 0.460
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.540 0.460
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.540 0.460
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.541 0.459
E27.2 Addisonian crisis
0.000 0.541 0.459
M10.94 Gout, unspecified (Hand)
0.000 0.542 0.458
E88.2 Lipomatosis, not elsewhere classified
0.000 0.542 0.458
M08.9 Juvenile arthritis, unspecified
0.002 0.542 0.456
M08.8 Other juvenile arthritis
0.002 0.542 0.456
M08.4 Pauciarticular juvenile arthritis
0.002 0.542 0.456
M08.3 Juvenile polyarthritis (seronegative)
0.002 0.542 0.456
M08.1 Juvenile ankylosing spondylitis
0.002 0.542 0.456
M09.8 Juvenile arthritis in other diseases classified elsewhere
0.002 0.543 0.455
M09.2 Juvenile arthritis in ulcerative colitis
0.002 0.543 0.455
M09.1 Juvenile arthritis in Crohn's disease [regional enteritis]
0.002 0.543 0.455
M09.0 Juvenile arthritis in psoriasis
0.002 0.543 0.455
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.543 0.457
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.543 0.457
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.543 0.457
E79.1 Lesch-Nyhan syndrome
0.000 0.543 0.457
M10.3 Gout due to impairment of renal function
0.001 0.543 0.456
M12.8 Other specific arthropathies, not elsewhere classified
0.002 0.545 0.454
M12.5 Traumatic arthropathy
0.002 0.545 0.454
M12.4 Intermittent hydrarthrosis
0.002 0.545 0.454
M12.1 Kaschin-Beck disease
0.002 0.545 0.454
M12.0 Chronic postrheumatic arthropathy [Jaccoud]
0.002 0.545 0.454
M05.09 Felty's syndrome (Site unspecified)
0.001 0.548 0.451
M05.08 Felty's syndrome (Other)
0.001 0.548 0.451
M05.07 Felty's syndrome (Ankle and foot)
0.001 0.548 0.451
M05.06 Felty's syndrome (Lower leg)
0.001 0.548 0.451
M05.05 Felty's syndrome (Pelvic region and thigh)
0.001 0.548 0.451
M05.04 Felty's syndrome (Hand)
0.001 0.548 0.451
M05.03 Felty's syndrome (Forearm)
0.001 0.548 0.451
M05.02 Felty's syndrome (Upper arm)
0.001 0.548 0.451
M05.01 Felty's syndrome (Shoulder region)
0.001 0.548 0.451
M05.00 Felty's syndrome (Multiple sites)
0.001 0.548 0.451
M05.19 Rheumatoid lung disease (Site unspecified)
0.001 0.548 0.451
M05.18 Rheumatoid lung disease (Other)
0.001 0.548 0.451
M05.17 Rheumatoid lung disease (Ankle and foot)
0.001 0.548 0.451
M05.16 Rheumatoid lung disease (Lower leg)
0.001 0.548 0.451
M05.15 Rheumatoid lung disease (Pelvic region and thigh)
0.001 0.548 0.451
M05.14 Rheumatoid lung disease (Hand)
0.001 0.548 0.451
M05.13 Rheumatoid lung disease (Forearm)
0.001 0.548 0.451
M05.12 Rheumatoid lung disease (Upper arm)
0.001 0.548 0.451
M05.11 Rheumatoid lung disease (Shoulder region)
0.001 0.548 0.451
M05.10 Rheumatoid lung disease (Multiple sites)
0.001 0.548 0.451
M05.39 Rheumatoid arthritis with involvement of other organs and systems (Site unspecified)
0.001 0.548 0.451
M05.38 Rheumatoid arthritis with involvement of other organs and systems (Other)
0.001 0.548 0.451
M05.37 Rheumatoid arthritis with involvement of other organs and systems (Ankle and foot)
0.001 0.548 0.451
M05.36 Rheumatoid arthritis with involvement of other organs and systems (Lower leg)
0.001 0.548 0.451
M05.35 Rheumatoid arthritis with involvement of other organs and systems (Pelvic region and thigh)
0.001 0.548 0.451
M05.34 Rheumatoid arthritis with involvement of other organs and systems (Hand)
0.001 0.548 0.451
M05.33 Rheumatoid arthritis with involvement of other organs and systems (Forearm)
0.001 0.548 0.451
M05.32 Rheumatoid arthritis with involvement of other organs and systems (Upper arm)
0.001 0.548 0.451
M05.31 Rheumatoid arthritis with involvement of other organs and systems (Shoulder region)
0.001 0.548 0.451
M05.30 Rheumatoid arthritis with involvement of other organs and systems (Multiple sites)
0.001 0.548 0.451
E84.9 Cystic fibrosis, unspecified
0.000 0.548 0.452
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.549 0.451
E20.8 Other hypoparathyroidism
0.000 0.549 0.451
E20.1 Pseudohypoparathyroidism
0.000 0.549 0.451
E20.0 Idiopathic hypoparathyroidism
0.000 0.549 0.451
E24.0 Pituitary-dependent Cushing's disease
0.000 0.552 0.448
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.554 0.446
M11.29 Other chondrocalcinosis (Site unspecified)
0.001 0.557 0.442
M11.28 Other chondrocalcinosis (Other)
0.001 0.557 0.442
M11.25 Other chondrocalcinosis (Pelvic region and thigh)
0.001 0.557 0.442
M11.24 Other chondrocalcinosis (Hand)
0.001 0.557 0.442
M11.23 Other chondrocalcinosis (Forearm)
0.001 0.557 0.442
M11.22 Other chondrocalcinosis (Upper arm)
0.001 0.557 0.442
M11.20 Other chondrocalcinosis (Multiple sites)
0.001 0.557 0.442
M35.99 Systemic involvement of connective tissue, unspecified, Site unspecified
0.000 0.557 0.442
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.558 0.442
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.558 0.442
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.558 0.442
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.558 0.442
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.558 0.442
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.558 0.442
E24.8 Other Cushing's syndrome
0.000 0.558 0.441
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.559 0.441
M14.8 Arthropathies in other specified diseases classified elsewhere
0.002 0.560 0.438
M14.2 Diabetic arthropathy
0.002 0.562 0.436
E44.1 Mild protein-energy malnutrition
0.000 0.562 0.438
E44.0 Moderate protein-energy malnutrition
0.000 0.562 0.438
E78.8 Other disorders of lipoprotein metabolism
0.000 0.563 0.437
E84.8 Cystic fibrosis with other manifestations
0.000 0.563 0.437
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.563 0.437
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.563 0.437

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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