TreeWAS – Variant ID: rs2157338

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.000	0.000	1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.000	0.000	1.000
E05.9 Thyrotoxicosis, unspecified	1.000	0.000	0.000
E05.0 Thyrotoxicosis with diffuse goitre	1.000	0.000	0.000
E10.9 Without complications	1.000	0.000	0.000
M05.9 Seropositive rheumatoid arthritis, unspecified	0.000	0.000	1.000
M06.9 Rheumatoid arthritis, unspecified	0.000	0.000	1.000
E05 Thyrotoxicosis [hyperthyroidism]	1.000	0.000	0.000
E10 Insulin-dependent diabetes mellitus	1.000	0.000	0.000
M06 Other rheumatoid arthritis	0.000	0.000	1.000
E10-E14 Diabetes mellitus	1.000	0.000	0.000
E00-E07 Disorders of thyroid gland	1.000	0.000	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	1.000	0.000	0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	1.000	0.000	0.000
# Top node	1.000	0.000	0.000
Chapter IX Diseases of the circulatory system	1.000	0.000	0.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)	0.000	0.000	1.000
E10.3 With ophthalmic complications	1.000	0.000	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	1.000	0.000	0.000
E10.1 With ketoacidosis	1.000	0.000	0.000
M05-M14 Inflammatory polyarthropathies	0.000	0.000	1.000
M05 Seropositive rheumatoid arthritis	0.000	0.000	1.000
E20-E35 Disorders of other endocrine glands	1.000	0.000	0.000
I70-I79 Diseases of arteries, arterioles and capillaries	0.999	0.001	0.000
D60-D64 Aplastic and other anaemias	0.999	0.001	0.000
E14 Unspecified diabetes mellitus	0.999	0.001	0.000
R31 Unspecified haematuria	0.000	0.001	0.999
E03 Other hypothyroidism	0.999	0.001	0.000
M15-M19 Arthrosis	0.998	0.002	0.000
D64 Other anaemias	0.998	0.002	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.998	0.002	0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.998	0.002	0.000
Q60-Q64 Congenital malformations of the urinary system	0.997	0.003	0.000
E03.9 Hypothyroidism, unspecified	0.997	0.003	0.000
D64.9 Anaemia, unspecified	0.997	0.003	0.000
Q38-Q45 Other congenital malformations of the digestive system	0.997	0.003	0.000
M17.1 Other primary gonarthrosis	0.996	0.004	0.000
M18 Arthrosis of first carpometacarpal joint	0.995	0.005	0.000
M17 Gonarthrosis [arthrosis of knee]	0.994	0.006	0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)	0.000	0.006	0.994
E14.9 Without complications	0.993	0.007	0.000
D69 Purpura and other haemorrhagic conditions	0.992	0.008	0.000
D50-D53 Nutritional anaemias	0.990	0.010	0.000
M35.0 Sicca syndrome [Sjogren]	0.987	0.013	0.000
M35 Other systemic involvement of connective tissue	0.985	0.015	0.000
M20-M25 Other joint disorders	0.984	0.016	0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)	0.000	0.018	0.982
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.982	0.018	0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.981	0.019	0.000
Q61 Cystic kidney disease	0.981	0.019	0.000
I10-I15 Hypertensive diseases	0.980	0.020	0.000
M06.3 Rheumatoid nodule	0.000	0.021	0.979
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.978	0.022	0.000
I60-I69 Cerebrovascular diseases	0.976	0.024	0.000
Q60 Renal agenesis and other reduction defects of kidney	0.976	0.024	0.000
I64 Stroke, not specified as haemorrhage or infarction	0.976	0.024	0.000
I12 Hypertensive renal disease	0.976	0.024	0.000
L40.9 Psoriasis, unspecified	0.000	0.025	0.975
D80-D89 Certain disorders involving the immune mechanism	0.975	0.025	0.000
D50 Iron deficiency anaemia	0.974	0.026	0.000
D50.9 Iron deficiency anaemia, unspecified	0.969	0.031	0.000
E16 Other disorders of pancreatic internal secretion	0.969	0.031	0.000
M18.0 Primary arthrosis of first carpometacarpal joints, bilateral	0.968	0.032	0.000
M18.1 Other primary arthrosis of first carpometacarpal joint	0.966	0.034	0.000
I12.9 Hypertensive renal disease without renal failure	0.964	0.036	0.000
D69.6 Thrombocytopenia, unspecified	0.963	0.037	0.000
Q43 Other congenital malformations of intestine	0.962	0.038	0.000
I79.2 Peripheral angiopathy in diseases classified elsewhere	0.961	0.039	0.000
E10.2 With renal complications	0.958	0.042	0.000
E16.2 Hypoglycaemia, unspecified	0.956	0.044	0.000
I20-I25 Ischaemic heart diseases	0.955	0.045	0.000
Q61.3 Polycystic kidney, unspecified	0.951	0.049	0.000
I24 Other acute ischaemic heart diseases	0.949	0.051	0.000
M06.0 Seronegative rheumatoid arthritis	0.000	0.053	0.947
M06.34 Rheumatoid nodule (Hand)	0.000	0.053	0.947
I24.8 Other forms of acute ischaemic heart disease	0.944	0.056	0.000
Chapter VII Diseases of the eye and adnexa	0.944	0.056	0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)	0.000	0.057	0.943
M60-M63 Disorders of muscles	0.941	0.059	0.000
H06.2 Dysthyroid exophthalmos	0.940	0.060	0.000
Q44 Congenital malformations of gallbladder, bile ducts and liver	0.940	0.060	0.000
D68 Other coagulation defects	0.940	0.060	0.000
H30-H36 Disorders of choroid and retina	0.940	0.060	0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit	0.939	0.061	0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere	0.939	0.061	0.000
D61 Other aplastic anaemias	0.936	0.064	0.000
E21.3 Hyperparathyroidism, unspecified	0.934	0.066	0.000
N00-N08 Glomerular diseases	0.931	0.069	0.000
E10.4 With neurological complications	0.930	0.070	0.000
D69.4 Other primary thrombocytopenia	0.930	0.070	0.000
E28 Ovarian dysfunction	0.928	0.072	0.000
H00.1 Chalazion	0.000	0.075	0.925
N08 Glomerular disorders in diseases classified elsewhere	0.925	0.075	0.000
I22 Subsequent myocardial infarction	0.922	0.078	0.000
N04 Nephrotic syndrome	0.922	0.078	0.000
N08.3 Glomerular disorders in diabetes mellitus	0.917	0.083	0.000
H36 Retinal disorders in diseases classified elsewhere	0.917	0.083	0.000
L40 Psoriasis	0.001	0.084	0.915
E14.3 With ophthalmic complications	0.915	0.085	0.000
E27 Other disorders of adrenal gland	0.915	0.085	0.000
M07 Psoriatic and enteropathic arthropathies	0.000	0.087	0.913
Q60.2 Renal agenesis, unspecified	0.910	0.090	0.000
M15 Polyarthrosis	0.910	0.090	0.000
Q60.0 Renal agenesis, unilateral	0.910	0.090	0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)	0.000	0.092	0.908
M32 Systemic lupus erythematosus	0.908	0.092	0.000
D55-D59 Haemolytic anaemias	0.907	0.093	0.000
I73 Other peripheral vascular diseases	0.905	0.095	0.000
N04.9 Unspecified	0.904	0.096	0.000
I71 Aortic aneurysm and dissection	0.903	0.097	0.000
H36.0 Diabetic retinopathy	0.901	0.099	0.000
N05 Unspecified nephritic syndrome	0.901	0.099	0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.000	0.100	0.900
Q43.9 Congenital malformation of intestine, unspecified	0.899	0.101	0.000
M24 Other specific joint derangements	0.898	0.102	0.000
D86 Sarcoidosis	0.897	0.103	0.000
E27.1 Primary adrenocortical insufficiency	0.897	0.103	0.000
H05 Disorders of orbit	0.895	0.105	0.000
I12.0 Hypertensive renal disease with renal failure	0.894	0.106	0.000
I62 Other nontraumatic intracranial haemorrhage	0.893	0.107	0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.000	0.107	0.893
I77 Other disorders of arteries and arterioles	0.890	0.110	0.000
Q44.6 Cystic disease of liver	0.889	0.111	0.000
I70 Atherosclerosis	0.887	0.113	0.000
I22.9 Subsequent myocardial infarction of unspecified site	0.883	0.117	0.000
E22 Hyperfunction of pituitary gland	0.880	0.120	0.000
H35 Other retinal disorders	0.879	0.121	0.000
Chapter XIV Diseases of the genitourinary system	0.878	0.122	0.000
I24.9 Acute ischaemic heart disease, unspecified	0.877	0.123	0.000
M06.00 Seronegative rheumatoid arthritis (Multiple sites)	0.000	0.123	0.877
I77.1 Stricture of artery	0.876	0.124	0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified	0.871	0.129	0.000
D61.9 Aplastic anaemia, unspecified	0.871	0.129	0.000
E40-E46 Malnutrition	0.871	0.129	0.000
E14.8 With unspecified complications	0.869	0.131	0.000
D51 Vitamin B12 deficiency anaemia	0.869	0.131	0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture	0.862	0.138	0.000
D64.8 Other specified anaemias	0.862	0.138	0.000
D68.8 Other specified coagulation defects	0.862	0.138	0.000
H05.2 Exophthalmic conditions	0.858	0.142	0.000
M35.7 Hypermobility syndrome	0.858	0.142	0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.856	0.144	0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.000	0.145	0.855
M32.1 Systemic lupus erythematosus with organ or system involvement	0.853	0.147	0.000
Q00-Q07 Congenital malformations of the nervous system	0.853	0.147	0.000
M06.37 Rheumatoid nodule (Ankle and foot)	0.000	0.148	0.852
I62.0 Subdural haemorrhage (acute) (nontraumatic)	0.851	0.149	0.000
M07.3 Other psoriatic arthropathies	0.000	0.150	0.850
M60 Myositis	0.850	0.150	0.000
E10.8 With unspecified complications	0.847	0.153	0.000
E21.0 Primary hyperparathyroidism	0.839	0.161	0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.837	0.163	0.000
M24.1 Other articular cartilage disorders	0.831	0.169	0.000
Q39 Congenital malformations of oesophagus	0.828	0.172	0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)	0.000	0.173	0.827
D68.0 Von Willebrand's disease	0.827	0.173	0.000
D80 Immunodeficiency with predominantly antibody defects	0.826	0.174	0.000
L40.0 Psoriasis vulgaris	0.000	0.175	0.824
N17-N19 Renal failure	0.825	0.175	0.000
E10.0 With coma	0.825	0.175	0.000
H34 Retinal vascular occlusions	0.823	0.177	0.000
M62 Other disorders of muscle	0.821	0.179	0.000
E20 Hypoparathyroidism	0.820	0.180	0.000
M35.1 Other overlap syndromes	0.820	0.180	0.000
D69.3 Idiopathic thrombocytopenic purpura	0.820	0.180	0.000
D68.6 Other Thrombophilia	0.820	0.180	0.000
E28.2 Polycystic ovarian syndrome	0.820	0.180	0.000
N05.1 Focal and segmental glomerular lesions	0.819	0.181	0.000
I27 Other pulmonary heart diseases	0.818	0.182	0.000
E34 Other endocrine disorders	0.817	0.183	0.000
Q38 Other congenital malformations of tongue, mouth and pharynx	0.817	0.183	0.000
E14.1 With ketoacidosis	0.817	0.183	0.000
E50-E64 Other nutritional deficiencies	0.816	0.184	0.000
I74 Arterial embolism and thrombosis	0.815	0.185	0.000
N18 Chronic renal failure	0.815	0.185	0.000
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)	0.000	0.185	0.815
E16.0 Drug-induced hypoglycaemia without coma	0.810	0.190	0.000
I73.9 Peripheral vascular disease, unspecified	0.810	0.190	0.000
H35.4 Peripheral retinal degeneration	0.810	0.190	0.000
E07 Other disorders of thyroid	0.808	0.192	0.000
M06.4 Inflammatory polyarthropathy	0.000	0.193	0.807
M14 Arthropathies in other diseases classified elsewhere	0.000	0.194	0.806
I27.2 Other secondary pulmonary hypertension	0.805	0.195	0.000
E10.5 With peripheral circulatory complications	0.804	0.196	0.000
N05.2 Diffuse membranous glomerulonephritis	0.804	0.196	0.000
E28.3 Primary ovarian failure	0.802	0.198	0.000
D86.9 Sarcoidosis, unspecified	0.802	0.198	0.000
E22.0 Acromegaly and pituitary gigantism	0.801	0.199	0.000
E10.7 With multiple complications	0.800	0.200	0.000
Q61.9 Cystic kidney disease, unspecified	0.798	0.202	0.000
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.798	0.202	0.000
N18.3 Chronic kidney disease, stage 3	0.797	0.203	0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.796	0.204	0.000
D86.3 Sarcoidosis of skin	0.795	0.205	0.000
M24.8 Other specific joint derangements, not elsewhere classified	0.794	0.206	0.000
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)	0.000	0.206	0.794
M24.5 Contracture of joint	0.793	0.207	0.000
I15 Secondary hypertension	0.788	0.212	0.000
M15.2 Bouchard's nodes (with arthropathy)	0.788	0.212	0.000
H35.8 Other specified retinal disorders	0.787	0.213	0.000
M34 Systemic sclerosis	0.787	0.213	0.000
Q61.2 Polycystic kidney, adult type	0.784	0.216	0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified	0.782	0.218	0.000
L40.5 Arthropathic psoriasis	0.000	0.218	0.782
H33 Retinal detachments and breaks	0.780	0.220	0.000
E46 Unspecified protein-energy malnutrition	0.779	0.221	0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction	0.779	0.221	0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.777	0.223	0.000
Q61.0 Congenital single renal cyst	0.777	0.223	0.000
Q40 Other congenital malformations of upper alimentary tract	0.776	0.224	0.000
D59 Acquired haemolytic anaemia	0.776	0.224	0.000
I22.8 Subsequent myocardial infarction of other sites	0.775	0.225	0.000
M11 Other crystal arthropathies	0.000	0.226	0.774
E31 Polyglandular dysfunction	0.774	0.226	0.000
H35.2 Other proliferative retinopathy	0.773	0.227	0.000
G50-G59 Nerve, nerve root and plexus disorders	0.773	0.227	0.000
Chapter VI Diseases of the nervous system	0.772	0.228	0.000
I73.0 Raynaud's syndrome	0.772	0.228	0.000
Q30-Q34 Congenital malformations of the respiratory system	0.771	0.229	0.000
E29 Testicular dysfunction	0.771	0.229	0.000
N04.2 Diffuse membranous glomerulonephritis	0.769	0.231	0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture	0.768	0.232	0.000
E03.8 Other specified hypothyroidism	0.766	0.234	0.000
N08.5 Glomerular disorders in systemic connective tissue disorders	0.766	0.234	0.000
M07.30 Other psoriatic arthropathies (Multiple sites)	0.000	0.235	0.765
I72 Other aneurysm	0.764	0.236	0.000
E06 Thyroiditis	0.764	0.236	0.000
Q43.3 Congenital malformations of intestinal fixation	0.761	0.239	0.000
D69.5 Secondary thrombocytopenia	0.760	0.240	0.000
M60.9 Myositis, unspecified	0.759	0.241	0.000
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)	0.000	0.241	0.759
N04.1 Focal and segmental glomerular lesions	0.758	0.242	0.000
E14.5 With peripheral circulatory complications	0.758	0.242	0.000
D83 Common variable immunodeficiency	0.757	0.243	0.000
H35.0 Background retinopathy and retinal vascular changes	0.757	0.243	0.000
D58 Other hereditary haemolytic anaemias	0.756	0.244	0.000
M24.11 Other articular cartilage disorders (Shoulder region)	0.755	0.245	0.000
D68.5 Primary Thrombophilia	0.751	0.249	0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]	0.751	0.249	0.000
M06.09 Seronegative rheumatoid arthritis (Site unspecified)	0.000	0.249	0.751
I70.0 Atherosclerosis of aorta	0.751	0.249	0.000
M06.06 Seronegative rheumatoid arthritis (Lower leg)	0.000	0.249	0.751
Q43.8 Other specified congenital malformations of intestine	0.751	0.249	0.000
D69.2 Other nonthrombocytopenic purpura	0.750	0.250	0.000
D89.9 Disorder involving the immune mechanism, unspecified	0.749	0.251	0.000
G56 Mononeuropathies of upper limb	0.749	0.251	0.000
E21.2 Other hyperparathyroidism	0.745	0.255	0.000
M24.15 Other articular cartilage disorders (Pelvic region and thigh)	0.745	0.255	0.000
M15.1 Heberden's nodes (with arthropathy)	0.745	0.255	0.000
G56.0 Carpal tunnel syndrome	0.744	0.256	0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified	0.743	0.257	0.000
Q63 Other congenital malformations of kidney	0.741	0.259	0.000
H34.8 Other retinal vascular occlusions	0.741	0.259	0.000
Q43.0 Meckel's diverticulum	0.740	0.260	0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.740	0.260	0.000
I22.1 Subsequent myocardial infarction of inferior wall	0.739	0.261	0.000
M18.9 Arthrosis of first carpometacarpal joint, unspecified	0.739	0.261	0.000
E24 Cushing's syndrome	0.735	0.265	0.000
Q43.1 Hirschsprung's disease	0.734	0.266	0.000
E34.8 Other specified endocrine disorders	0.733	0.267	0.000
D61.0 Constitutional aplastic anaemia	0.732	0.268	0.000
D50.1 Sideropenic dysphagia	0.731	0.269	0.000
E14.2 Withrenal complications	0.731	0.269	0.000
E23 Hypofunction and other disorders of pituitary gland	0.729	0.271	0.000
L40.8 Other psoriasis	0.001	0.271	0.728
Q44.5 Other congenital malformations of bile ducts	0.729	0.271	0.000
E70-E90 Metabolic disorders	0.727	0.273	0.000
E89.0 Postprocedural hypothyroidism	0.726	0.274	0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction	0.724	0.276	0.000
M62.8 Other specified disorders of muscle	0.723	0.277	0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.722	0.278	0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.722	0.278	0.000
D68.1 Hereditary factor XI deficiency	0.721	0.278	0.000
Q45 Other congenital malformations of digestive system	0.720	0.280	0.000
H00 Hordeolum and chalazion	0.279	0.281	0.440
I70.1 Atherosclerosis of renal artery	0.719	0.281	0.000
H05.0 Acute inflammation of orbit	0.719	0.281	0.000
M06.49 Inflammatory polyarthropathy (Site unspecified)	0.000	0.281	0.719
N05.8 Other	0.718	0.282	0.000
I74.2 Embolism and thrombosis of arteries of the upper extremities	0.718	0.282	0.000
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)	0.000	0.283	0.717
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.000	0.283	0.717
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)	0.000	0.283	0.717
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)	0.000	0.283	0.717
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)	0.000	0.283	0.717
E05.5 Thyroid crisis or storm	0.717	0.283	0.000
E05.4 Thyrotoxicosis factitia	0.717	0.283	0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.717	0.283	0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.717	0.283	0.000
M06.8 Other specified rheumatoid arthritis	0.000	0.283	0.717
M06.2 Rheumatoid bursitis	0.000	0.283	0.717
M06.1 Adult-onset Still's disease	0.000	0.283	0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.717	0.283	0.000
E00 Congenital iodine-deficiency syndrome	0.717	0.283	0.000
E12 Malnutrition-related diabetes mellitus	0.717	0.283	0.000
Chapter XVI Certain conditions originating in the perinatal period	0.717	0.283	0.000
M05.8 Other seropositive rheumatoid arthritis	0.000	0.283	0.717
M05.3 Rheumatoid arthritis with involvement of other organs and systems	0.000	0.283	0.717
M05.2 Rheumatoid vasculitis	0.000	0.283	0.717
M05.1 Rheumatoid lung disease	0.000	0.283	0.717
M05.0 Felty's syndrome	0.000	0.283	0.717
M09 Juvenile arthritis in diseases classified elsewhere	0.000	0.283	0.717
M08 Juvenile arthritis	0.000	0.283	0.717
E35 Disorders of endocrine glands in diseases classified elsewhere	0.717	0.283	0.000
E32 Diseases of thymus	0.717	0.283	0.000
E30 Disorders of puberty, not elsewhere classified	0.717	0.283	0.000
E25 Adrenogenital disorders	0.717	0.283	0.000
E14.7 With multiple complications	0.716	0.283	0.000
E14.0 With coma	0.716	0.283	0.000
E03.5 Myxoedema coma	0.716	0.284	0.000
E03.4 Atrophy of thyroid (acquired)	0.716	0.284	0.000
E03.3 Postinfectious hypothyroidism	0.716	0.284	0.000
E03.1 Congenital hypothyroidism without goitre	0.716	0.284	0.000
E03.0 Congenital hypothyroidism with diffuse goitre	0.716	0.284	0.000
E07.8 Other specified disorders of thyroid	0.716	0.284	0.000
D64.4 Congenital dyserythropoietic anaemia	0.716	0.284	0.000
D64.3 Other sideroblastic anaemias	0.716	0.284	0.000
D64.2 Secondary sideroblastic anaemia due to drugs and toxins	0.716	0.284	0.000
D64.1 Secondary sideroblastic anaemia due to disease	0.716	0.284	0.000
D64.0 Hereditary sideroblastic anaemia	0.716	0.284	0.000
D67 Hereditary factor IX deficiency	0.715	0.284	0.000
Q42 Congenital absence, atresia and stenosis of large intestine	0.715	0.285	0.000
Q41 Congenital absence, atresia and stenosis of small intestine	0.715	0.285	0.000
M17.2 Posttraumatic gonarthrosis, bilateral	0.714	0.286	0.000
E61 Deficiency of other nutrient elements	0.714	0.286	0.000
M18.5 Other secondary arthrosis of first carpometacarpal joint	0.713	0.287	0.000
M18.4 Other secondary arthrosis of first carpometacarpal joints, bilateral	0.713	0.287	0.000
M18.3 Other posttraumatic arthrosis of first carpometacarpal joint	0.713	0.287	0.000
M18.2 Posttraumatic arthrosis of first carpometacarpal joints, bilateral	0.713	0.287	0.000
D53 Other nutritional anaemias	0.713	0.287	0.000
Q35-Q37 Cleft lip and cleft palate	0.712	0.288	0.000
H33.3 Retinal breaks without detachment	0.712	0.288	0.000
D69.8 Other specified haemorrhagic conditions	0.711	0.289	0.000
D69.1 Qualitative platelet defects	0.711	0.289	0.000
M17.4 Other secondary gonarthrosis, bilateral	0.710	0.290	0.000
M15.8 Other polyarthrosis	0.709	0.291	0.000
I65.0 Occlusion and stenosis of vertebral artery	0.709	0.291	0.000
I00-I02 Acute rheumatic fever	0.707	0.293	0.000
G51 Facial nerve disorders	0.707	0.293	0.000
M35.9 Systemic involvement of connective tissue, unspecified	0.706	0.294	0.000
M35.6 Relapsing panniculitis [Weber-Christian]	0.706	0.294	0.000
M35.5 Multifocal fibrosclerosis	0.706	0.294	0.000
M35.4 Diffuse (eosinophilic) fasciitis	0.706	0.294	0.000
D89.1 Cryoglobulinaemia	0.706	0.294	0.000
M24.54 Contracture of joint (Hand)	0.706	0.294	0.000
Chapter XII Diseases of the skin and subcutaneous tissue	0.705	0.295	0.001
E15 Nondiabetic hypoglycaemic coma	0.704	0.296	0.000
I79.1 Aortitis in diseases classified elsewhere	0.703	0.296	0.000
I79.0 Aneurysm of aorta in diseases classified elsewhere	0.703	0.296	0.000
Q61.8 Other cystic kidney diseases	0.703	0.297	0.000
Q61.4 Renal dysplasia	0.703	0.297	0.000
Q61.1 Polycystic kidney, infantile type	0.703	0.297	0.000
I13 Hypertensive heart and renal disease	0.703	0.297	0.000
M06.39 Rheumatoid nodule (Site unspecified)	0.000	0.298	0.702
M06.38 Rheumatoid nodule (Other)	0.000	0.298	0.702
M06.36 Rheumatoid nodule (Lower leg)	0.000	0.298	0.702
M06.35 Rheumatoid nodule (Pelvic region and thigh)	0.000	0.298	0.702
M06.33 Rheumatoid nodule (Forearm)	0.000	0.298	0.702
M06.32 Rheumatoid nodule (Upper arm)	0.000	0.298	0.702
M06.31 Rheumatoid nodule (Shoulder region)	0.000	0.298	0.702
M06.30 Rheumatoid nodule (Multiple sites)	0.000	0.298	0.702
Q74 Other congenital malformations of limb(s)	0.701	0.299	0.000
E21.5 Disorder of parathyroid gland, unspecified	0.701	0.299	0.000
E21.4 Other specified disorders of parathyroid gland	0.701	0.299	0.000
Q60.6 Potter's syndrome	0.700	0.300	0.000
Q60.5 Renal hypoplasia, unspecified	0.700	0.300	0.000
Q60.4 Renal hypoplasia, bilateral	0.700	0.300	0.000
Q60.3 Renal hypoplasia, unilateral	0.700	0.300	0.000
Q60.1 Renal agenesis, bilateral	0.700	0.300	0.000
D81 Combined immunodeficiencies	0.699	0.301	0.000
I68 Cerebrovascular disorders in diseases classified elsewhere	0.699	0.301	0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.697	0.303	0.000
D80.2 Selective deficiency of immunoglobulin A [IgA]	0.697	0.303	0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system	0.696	0.304	0.000
M07.39 Other psoriatic arthropathies (Site unspecified)	0.000	0.304	0.696
Q39.9 Congenital malformation of oesophagus, unspecified	0.695	0.305	0.000
E16.9 Disorder of pancreatic internal secretion, unspecified	0.695	0.305	0.000
E16.8 Other specified disorders of pancreatic internal secretion	0.695	0.305	0.000
E16.4 Abnormal secretion of gastrin	0.695	0.305	0.000
E16.3 Increased secretion of glucagon	0.695	0.305	0.000
D61.1 Drug-induced aplastic anaemia	0.694	0.306	0.000
E14.4 With neurological complications	0.694	0.306	0.000
I70.8 Atherosclerosis of other arteries	0.693	0.307	0.000
N18.0 End-stage renal disease	0.693	0.307	0.000
E20.9 Hypoparathyroidism, unspecified	0.692	0.308	0.000
E27.9 Disorder of adrenal gland, unspecified	0.691	0.309	0.000
M15.4 Erosive (osteo)arthrosis	0.691	0.309	0.000
D69.9 Haemorrhagic condition, unspecified	0.691	0.309	0.000
Q39.6 Diverticulum of oesophagus	0.690	0.310	0.000
Q43.7 Persistent cloaca	0.690	0.310	0.000
Q43.6 Congenital fistula of rectum and anus	0.690	0.310	0.000
Q43.5 Ectopic anus	0.690	0.310	0.000
Q43.4 Duplication of intestine	0.690	0.310	0.000
Q43.2 Other congenital functional disorders of colon	0.690	0.310	0.000
M24.85 Other specific joint derangements, not elsewhere classified (Pelvic region and thigh)	0.689	0.311	0.000
M86-M90 Other osteopathies	0.689	0.311	0.000
M60.99 Myositis, unspecified (Site unspecified)	0.687	0.313	0.000
Q03 Congenital hydrocephalus	0.685	0.315	0.000
D56 Thalassaemia	0.685	0.315	0.000
M33 Dermatopolymyositis	0.684	0.316	0.000
M14.6 Neuropathic arthropathy	0.000	0.316	0.684
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture	0.684	0.316	0.000
E14.6 With other specified complications	0.684	0.316	0.000
M12 Other specific arthropathies	0.000	0.317	0.683
D86.8 Sarcoidosis of other and combined sites	0.682	0.318	0.000
N18.2 Chronic kidney disease, stage 2	0.681	0.319	0.000
M06.08 Seronegative rheumatoid arthritis (Other)	0.000	0.321	0.679
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)	0.000	0.321	0.679
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)	0.000	0.321	0.679
M06.04 Seronegative rheumatoid arthritis (Hand)	0.000	0.321	0.679
M06.03 Seronegative rheumatoid arthritis (Forearm)	0.000	0.321	0.679
M06.02 Seronegative rheumatoid arthritis (Upper arm)	0.000	0.321	0.679
M06.01 Seronegative rheumatoid arthritis (Shoulder region)	0.000	0.321	0.679
M23 Internal derangement of knee	0.679	0.321	0.000
Q07 Other congenital malformations of nervous system	0.678	0.322	0.000
L10-L14 Bullous disorders	0.676	0.324	0.000
M60.0 Infective myositis	0.675	0.325	0.000
D52 Folate deficiency anaemia	0.675	0.325	0.000
G58 Other mononeuropathies	0.675	0.325	0.000
M63 Disorders of muscle in diseases classified elsewhere	0.675	0.325	0.000
M61 Calcification and ossification of muscle	0.675	0.325	0.000
Q38.1 Ankyloglossia	0.674	0.326	0.000
Q44.7 Other congenital malformations of liver	0.674	0.326	0.000
Q44.4 Choledochal cyst	0.674	0.326	0.000
Q44.3 Congenital stenosis and stricture of bile ducts	0.674	0.326	0.000
Q44.2 Atresia of bile ducts	0.674	0.326	0.000
Q44.1 Other congenital malformations of gallbladder	0.674	0.326	0.000
Q44.0 Agenesis, aplasia and hypoplasia of gallbladder	0.674	0.326	0.000
D68.4 Acquired coagulation factor deficiency	0.674	0.326	0.000
H32 Chorioretinal disorders in diseases classified elsewhere	0.674	0.326	0.000
I27.9 Pulmonary heart disease, unspecified	0.673	0.327	0.000
H06.3 Other disorders of orbit in diseases classified elsewhere	0.673	0.327	0.000
H06.1 Parasitic infestation of orbit in diseases classified elsewhere	0.673	0.327	0.000
H06.0 Disorders of lachrymal system in diseases classified elsewhere	0.673	0.327	0.000
N00 Acute nephritic syndrome	0.672	0.328	0.000
D82 Immunodeficiency associated with other major defects	0.671	0.329	0.000
D61.8 Other specified aplastic anaemias	0.671	0.329	0.000
D61.3 Idiopathic aplastic anaemia	0.671	0.329	0.000
D61.2 Aplastic anaemia due to other external agents	0.671	0.329	0.000
N05.5 Diffuse mesangiocapillary glomerulonephritis	0.670	0.330	0.000
M35.2 Behcet's disease	0.669	0.330	0.000
L40.1 Generalised pustular psoriasis	0.001	0.331	0.668
N07 Hereditary nephropathy, not elsewhere classified	0.667	0.332	0.000
N06 Isolated proteinuria with specified morphological lesion	0.667	0.332	0.000
N01 Rapidly progressive nephritic syndrome	0.667	0.332	0.000
H34.2 Other retinal artery occlusions	0.666	0.334	0.000
M07.36 Other psoriatic arthropathies (Lower leg)	0.000	0.335	0.665
E28.9 Ovarian dysfunction, unspecified	0.665	0.335	0.000
E28.8 Other ovarian dysfunction	0.665	0.335	0.000
E28.1 Androgen excess	0.665	0.335	0.000
E28.0 Oestrogen excess	0.665	0.335	0.000
M24.84 Other specific joint derangements, not elsewhere classified (Hand)	0.665	0.335	0.000
G57 Mononeuropathies of lower limb	0.665	0.335	0.000
N08.8 Glomerular disorders in other diseases classified elsewhere	0.663	0.337	0.000
N08.4 Glomerular disorders in other endocrine, nutritional and metabolic diseases	0.663	0.337	0.000
N08.2 Glomerular disorders in blood diseases and disorders involving the immune mechanism	0.663	0.337	0.000
N08.1 Glomerular disorders in neoplastic diseases	0.663	0.337	0.000
N08.0 Glomerular disorders in infectious and parasitic diseases classified elsewhere	0.663	0.337	0.000
Q61.5 Medullary cystic kidney	0.663	0.337	0.000
G20-G26 Extrapyramidal and movement disorders	0.663	0.337	0.000
I23 Certain current complications following acute myocardial infarction	0.662	0.338	0.000
N05.3 Diffuse mesangial proliferative glomerulonephritis	0.661	0.339	0.000
N04.8 Other	0.661	0.339	0.000
N04.7 Diffuse crescentic glomerulonephritis	0.661	0.339	0.000
N04.6 Dense deposit disease	0.661	0.339	0.000
N04.5 Diffuse mesangiocapillary glomerulonephritis	0.661	0.339	0.000
N04.4 Diffuse endocapillary proliferative glomerulonephritis	0.661	0.339	0.000
N04.3 Diffuse mesangial proliferative glomerulonephritis	0.661	0.339	0.000
N04.0 Minor glomerular abnormality	0.661	0.339	0.000
Q04 Other congenital malformations of brain	0.661	0.339	0.000
Q65 Congenital deformities of hip	0.660	0.340	0.000
D89.0 Polyclonal hypergammaglobulinaemia	0.660	0.340	0.000
D59.1 Other autoimmune haemolytic anaemias	0.659	0.341	0.000
M24.51 Contracture of joint (Shoulder region)	0.658	0.342	0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities	0.658	0.342	0.000
G51.0 Bell's palsy	0.658	0.342	0.000
H36.8 Other retinal disorders in diseases classified elsewhere	0.658	0.342	0.000
I77.2 Rupture of artery	0.658	0.342	0.000
H05.8 Other disorders of orbit	0.657	0.343	0.000
H30 Chorioretinal inflammation	0.657	0.343	0.000
L40.4 Guttate psoriasis	0.001	0.343	0.656
L40.2 Acrodermatitis continua	0.001	0.343	0.656
E27.5 Adrenomedullary hyperfunction	0.656	0.344	0.000
E27.0 Other adrenocortical overactivity	0.656	0.344	0.000
Q64 Other congenital malformations of urinary system	0.656	0.344	0.000
E02 Subclinical iodine-deficiency hypothyroidism	0.654	0.345	0.000
M07.6 Other enteropathic arthropathies	0.000	0.345	0.654
M07.5 Arthropathy in ulcerative colitis	0.000	0.345	0.654
M07.4 Arthropathy in Crohn's disease [regional enteritis]	0.000	0.345	0.654
M07.2 Psoriatic spondylitis	0.000	0.345	0.654
M07.1 Arthritis mutilans	0.000	0.345	0.654
M07.0 Distal interphalangeal psoriatic arthropathy	0.000	0.345	0.654
I11 Hypertensive heart disease	0.654	0.346	0.000
I70.00 Atherosclerosis of aorta (without gangrene)	0.654	0.346	0.000
M15.0 Primary generalised (osteo)arthrosis	0.653	0.347	0.000
M15.3 Secondary multiple arthrosis	0.653	0.347	0.000
I73.1 Thromboangiitis obliterans [Buerger]	0.652	0.348	0.000
M32.9 Systemic lupus erythematosus, unspecified	0.651	0.349	0.000
M32.8 Other forms of systemic lupus erythematosus	0.651	0.349	0.000
M32.0 Drug-induced systemic lupus erythematosus	0.651	0.349	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations