TreeWAS – Variant ID: rs2228671

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E78.0 Pure hypercholesterolaemia	0.000	0.000	1.000
I25.1 Atherosclerotic heart disease	0.000	0.000	1.000
I25 Chronic ischaemic heart disease	0.000	0.000	1.000
I20-I25 Ischaemic heart diseases	0.000	0.000	1.000
I20 Angina pectoris	0.000	0.000	1.000
I20.9 Angina pectoris, unspecified	0.000	0.000	1.000
I21 Acute myocardial infarction	0.000	0.002	0.998
I21.1 Acute transmural myocardial infarction of inferior wall	0.000	0.003	0.997
I25.2 Old myocardial infarction	0.000	0.012	0.988
I25.9 Chronic ischaemic heart disease, unspecified	0.000	0.019	0.981
E78 Disorders of lipoprotein metabolism and other lipidaemias	0.000	0.024	0.976
E78.5 Hyperlipidaemia, unspecified	0.000	0.030	0.970
Z95.1 Presence of aortocoronary bypass graft	0.000	0.065	0.935
I25.8 Other forms of chronic ischaemic heart disease	0.000	0.088	0.912
I24 Other acute ischaemic heart diseases	0.000	0.095	0.905
I25.3 Aneurysm of heart	0.000	0.104	0.896
I20.8 Other forms of angina pectoris	0.000	0.115	0.885
Z95.5 Presence of coronary angioplasty implant and graft	0.000	0.152	0.848
Z95 Presence of cardiac and vascular implants and grafts	0.000	0.158	0.842
I24.9 Acute ischaemic heart disease, unspecified	0.000	0.170	0.829
I21.3 Acute transmural myocardial infarction of unspecified site	0.000	0.181	0.819
I22 Subsequent myocardial infarction	0.000	0.185	0.815
I21.4 Acute subendocardial myocardial infarction	0.000	0.207	0.793
I20.0 Unstable angina	0.000	0.246	0.754
I22.1 Subsequent myocardial infarction of inferior wall	0.000	0.251	0.749
E78.4 Other hyperlipidaemia	0.000	0.259	0.741
E78.8 Other disorders of lipoprotein metabolism	0.000	0.261	0.739
E78.9 Disorder of lipoprotein metabolism, unspecified	0.000	0.263	0.737
I23 Certain current complications following acute myocardial infarction	0.000	0.271	0.729
I25.6 Silent myocardial ischaemia	0.000	0.283	0.717
I21.X Presumed acute myicardial infaction (unconfirmed)	0.000	0.284	0.716
I20.1 Angina pectoris with documented spasm	0.000	0.288	0.712
I25.0 Atherosclerotic cardiovascular disease, so described	0.000	0.291	0.709
E78.6 Lipoprotein deficiency	0.000	0.300	0.700
E78.3 Hyperchylomicronaemia	0.000	0.300	0.700
I24.8 Other forms of acute ischaemic heart disease	0.000	0.308	0.692
E78.1 Pure hyperglyceridaemia	0.000	0.320	0.680
E78.2 Mixed hyperlipidaemia	0.000	0.321	0.679
I25.4 Coronary artery aneurysm	0.000	0.327	0.673
I22.8 Subsequent myocardial infarction of other sites	0.000	0.330	0.670
M50-M54 Other dorsopathies	0.669	0.331	0.000
M13.9 Arthritis, unspecified	0.668	0.332	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.666	0.334	0.000
M13.97 Arthritis, unspecified (Ankle and foot)	0.661	0.339	0.000
M13 Other arthritis	0.657	0.343	0.000
M13.91 Arthritis, unspecified (Shoulder region)	0.656	0.344	0.000
M05-M14 Inflammatory polyarthropathies	0.654	0.346	0.000
M50 Cervical disk disorders	0.646	0.354	0.000
I24.1 Dressler's syndrome	0.000	0.355	0.645
I25.5 Ischaemic cardiomyopathy	0.000	0.363	0.637
M13.94 Arthritis, unspecified (Hand)	0.637	0.363	0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction	0.000	0.365	0.635
M45-M49 Spondylopathies	0.632	0.368	0.000
M80-M85 Disorders of bone density and structure	0.623	0.377	0.000
I21.0 Acute transmural myocardial infarction of anterior wall	0.000	0.379	0.621
M40-M43 Deforming dorsopathies	0.614	0.386	0.000
M54 Dorsalgia	0.614	0.386	0.000
Z95.2 Presence of prosthetic heart valve	0.000	0.392	0.608
M60-M63 Disorders of muscles	0.600	0.400	0.000
M50.0 Cervical disk disorder with myelopathy	0.599	0.401	0.000
M54.5 Low back pain	0.592	0.408	0.000
M53 Other dorsopathies, not elsewhere classified	0.581	0.419	0.000
M51 Other intervertebral disk disorders	0.572	0.428	0.000
M85 Other disorders of bone density and structure	0.567	0.433	0.000
M62 Other disorders of muscle	0.559	0.441	0.000
M84 Disorders of continuity of bone	0.554	0.445	0.000
M50.2 Other cervical disk displacement	0.551	0.449	0.000
M13.92 Arthritis, unspecified (Upper arm)	0.541	0.459	0.000
M54.2 Cervicalgia	0.540	0.460	0.000
M43 Other deforming dorsopathies	0.540	0.460	0.000
M86-M90 Other osteopathies	0.539	0.461	0.000
M54.56 Low back pain (Lumbar region)	0.539	0.461	0.000
I23.8 Other current complications following acute myocardial infarction	0.000	0.465	0.534
I21.2 Acute transmural myocardial infarction of other sites	0.000	0.474	0.526
M13.93 Arthritis, unspecified (Forearm)	0.525	0.475	0.000
M45 Ankylosing spondylitis	0.525	0.475	0.000
M48 Other spondylopathies	0.523	0.477	0.000
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction	0.000	0.477	0.523
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction	0.000	0.477	0.523
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction	0.000	0.477	0.523
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction	0.000	0.477	0.523
I23.2 Ventricular septal defect as current complication following acute myocardial infarction	0.000	0.477	0.523
I23.1 Atrial septal defect as current complication following acute myocardial infarction	0.000	0.477	0.523
I23.0 Haemopericardium as current complication following acute myocardial infarction	0.000	0.477	0.523
M51.8 Other specified intervertebral disk disorders	0.520	0.480	0.000
M54.50 Low back pain (Multiple sites in spine)	0.520	0.480	0.000
M53.3 Sacrococcygeal disorders, not elsewhere classified	0.518	0.482	0.000
M50.1 Cervical disk disorder with radiculopathy	0.517	0.483	0.000
M85.8 Other specified disorders of bone density and structure	0.517	0.483	0.000
M46 Other inflammatory spondylopathies	0.516	0.484	0.000
M41 Scoliosis	0.513	0.487	0.000
I21.9 Acute myocardial infarction, unspecified	0.000	0.494	0.506
M49 Spondylopathies in diseases classified elsewhere	0.505	0.495	0.000
M54.6 Pain in thoracic spine	0.504	0.496	0.000
M70-M79 Other soft tissue disorders	0.503	0.497	0.000
M62.8 Other specified disorders of muscle	0.499	0.501	0.000
M54.58 Low back pain (Sacral and sacrococcygeal region)	0.494	0.506	0.000
M14 Arthropathies in other diseases classified elsewhere	0.491	0.508	0.000
Z95.0 Presence of cardiac pacemaker	0.000	0.509	0.491
M43.1 Spondylolisthesis	0.489	0.511	0.000
M47 Spondylosis	0.487	0.513	0.000
M50.9 Cervical disk disorder, unspecified	0.486	0.514	0.000
M62.5 Muscle wasting and atrophy, not elsewhere classified	0.482	0.518	0.000
M54.57 Low back pain (Lumbosacral region)	0.481	0.519	0.000
M54.22 Cervicalgia (Cervical region)	0.479	0.521	0.000
M12 Other specific arthropathies	0.474	0.526	0.000
M53.38 Sacrococcygeal disorders, not elsewhere classified-Sacral/s	0.473	0.527	0.000
I22.0 Subsequent myocardial infarction of anterior wall	0.000	0.529	0.471
M13.1 Monoarthritis, not elsewhere classified	0.471	0.529	0.000
M85.89 Other specified disorders of bone density and structure (Site unspecified)	0.470	0.530	0.000
M84.1 Nonunion of fracture [pseudarthrosis]	0.470	0.530	0.000
M09 Juvenile arthritis in diseases classified elsewhere	0.469	0.531	0.000
M08 Juvenile arthritis	0.469	0.531	0.000
M79 Other soft tissue disorders, not elsewhere classified	0.466	0.534	0.000
M43.17 Spondylolisthesis (Lumbosacral region)	0.466	0.534	0.000
M40 Kyphosis and lordosis	0.464	0.536	0.000
M13.8 Other specified arthritis	0.464	0.536	0.000
M50.8 Other cervical disk disorders	0.463	0.536	0.000
M85.6 Other cyst of bone	0.463	0.537	0.000
M80 Osteoporosis with pathological fracture	0.462	0.537	0.000
M51.2 Other specified intervertebral disk displacement	0.462	0.538	0.000
M79.8 Other specified soft tissue disorders	0.456	0.544	0.000
M86 Osteomyelitis	0.451	0.549	0.000
M84.3 Stress fracture, not elsewhere classified	0.447	0.553	0.000
M50.3 Other cervical disk degeneration	0.447	0.553	0.000
M83 Adult osteomalacia	0.446	0.553	0.000
Z95.8 Presence of other cardiac and vascular implants and grafts	0.000	0.554	0.446
M45.X0 Ankylosing spondylitis (Multiple sites in spine)	0.446	0.554	0.000
M62.80 Other specified disorders of muscle (Multiple sites)	0.445	0.555	0.000
M51.4 Schmorl's nodes	0.442	0.558	0.000
M42 Spinal osteochondrosis	0.441	0.559	0.000
M00-M03 Infectious arthropathies	0.440	0.559	0.000
M54.0 Panniculitis affecting regions of neck and back	0.440	0.560	0.000
Z95.9 Presence of cardiac and vascular implant and graft, unspecified	0.000	0.560	0.440
M48.0 Spinal stenosis	0.439	0.561	0.000
M82 Osteoporosis in diseases classified elsewhere	0.439	0.561	0.000
M84.4 Pathological fracture, not elsewhere classified	0.438	0.562	0.000
M89 Other disorders of bone	0.437	0.563	0.000
M46.9 Inflammatory spondylopathy, unspecified	0.437	0.563	0.000
M79.84 Other specified soft tissue disorders (Hand)	0.436	0.564	0.000
M63 Disorders of muscle in diseases classified elsewhere	0.431	0.569	0.000
M61 Calcification and ossification of muscle	0.431	0.569	0.000
M85.85 Other specified disorders of bone density and structure (Pelvic region and thigh)	0.427	0.573	0.000
M54.64 Pain in thoracic spine (Thoracic region)	0.425	0.575	0.000
M54.54 Low back pain-Thoracic	0.424	0.576	0.000
M54.53 Low back pain-Cervicothoracic	0.424	0.576	0.000
M54.52 Low back pain-Cervical	0.424	0.576	0.000
M54.51 Low back pain-Occipit-atl-axl	0.424	0.576	0.000
M07 Psoriatic and enteropathic arthropathies	0.422	0.577	0.000
M62.56 Muscle wasting and atrophy, not elsewhere classified (Lower leg)	0.422	0.578	0.000
M84.12 Nonunion of fracture [pseudarthrosis] (Upper arm)	0.421	0.579	0.000
M84.11 Nonunion of fracture [pseudarthrosis] (Shoulder region)	0.421	0.579	0.000
M41.9 Scoliosis, unspecified	0.420	0.580	0.000
M48.06 Spinal stenosis (Lumbar region)	0.419	0.581	0.000
M54.8 Other dorsalgia	0.418	0.582	0.000
M53.9 Dorsopathy, unspecified	0.417	0.583	0.000
M53.8 Other specified dorsopathies	0.417	0.583	0.000
M53.2 Spinal instabilities	0.417	0.583	0.000
M53.1 Cervicobrachial syndrome	0.417	0.583	0.000
M53.0 Cervicocranial syndrome	0.417	0.583	0.000
Z95.3 Presence of xenogenic heart valve	0.000	0.585	0.415
M49.5 Collapsed vertebra in diseases classified elsewhere	0.414	0.586	0.000
M05 Seropositive rheumatoid arthritis	0.413	0.586	0.000
M54.1 Radiculopathy	0.411	0.589	0.000
M84.18 Nonunion of fracture [pseudarthrosis] (Other)	0.410	0.590	0.000
M51.3 Other specified intervertebral disk degeneration	0.410	0.590	0.000
M51.1 Lumbar and other intervertebral disk disorders with radiculopathy	0.410	0.590	0.000
M85.9 Disorder of bone density and structure, unspecified	0.407	0.593	0.000
M85.5 Aneurysmal bone cyst	0.407	0.593	0.000
M85.4 Solitary bone cyst	0.407	0.593	0.000
M85.3 Osteitis condensans	0.407	0.593	0.000
M85.2 Hyperostosis of skull	0.407	0.593	0.000
M85.1 Skeletal fluorosis	0.407	0.593	0.000
M60 Myositis	0.407	0.593	0.000
M54.29 Cervicalgia-Site unspe	0.406	0.594	0.000
M11 Other crystal arthropathies	0.404	0.596	0.000
M47.8 Other spondylosis	0.404	0.596	0.000
M13.98 Arthritis, unspecified (Other)	0.404	0.596	0.000
M62.82 Other specified disorders of muscle (Upper arm)	0.403	0.597	0.000
M46.96 Inflammatory spondylopathy, unspecified (Lumbar region)	0.403	0.597	0.000
M41.8 Other forms of scoliosis	0.401	0.599	0.000
M62.9 Disorder of muscle, unspecified	0.401	0.599	0.000
M62.6 Muscle strain	0.401	0.599	0.000
M62.4 Contracture of muscle	0.401	0.599	0.000
M62.3 Immobility syndrome (paraplegic)	0.401	0.599	0.000
M62.2 Ischaemic infarction of muscle	0.401	0.599	0.000
M62.1 Other rupture of muscle (nontraumatic)	0.401	0.599	0.000
M62.0 Diastasis of muscle	0.401	0.599	0.000
M45.X9 Ankylosing spondylitis (Site unspecified)	0.401	0.599	0.000
M84.9 Disorder of continuity of bone, unspecified	0.398	0.602	0.000
M84.8 Other disorders of continuity of bone	0.398	0.602	0.000
M84.2 Delayed union of fracture	0.398	0.602	0.000
M70 Soft tissue disorders related to use, overuse and pressure	0.397	0.603	0.000
M79.86 Other specified soft tissue disorders (Lower leg)	0.397	0.603	0.000
M43.6 Torticollis	0.396	0.604	0.000
M13.95 Arthritis, unspecified (Pelvic region and thigh)	0.395	0.605	0.000
M10 Gout	0.394	0.605	0.000
M51.9 Intervertebral disk disorder, unspecified	0.394	0.606	0.000
M54.23 Cervicalgia (Cervicothoracic region)	0.391	0.609	0.000
M62.81 Other specified disorders of muscle (Shoulder region)	0.390	0.610	0.000
M89.0 Algoneurodystrophy	0.388	0.612	0.000
M79.82 Other specified soft tissue disorders (Upper arm)	0.388	0.612	0.000
M54.28 Cervicalgia-Sacral/sacrococ	0.387	0.612	0.000
M54.27 Cervicalgia-Lumbosacral	0.387	0.612	0.000
M54.26 Cervicalgia-Lumbar	0.387	0.612	0.000
M54.25 Cervicalgia-Thoracolumbar	0.387	0.612	0.000
M54.24 Cervicalgia-Thoracic	0.387	0.612	0.000
M54.21 Cervicalgia (Occipito-atlanto-axial region)	0.387	0.612	0.000
M54.20 Cervicalgia-Mult site	0.387	0.612	0.000
M43.9 Deforming dorsopathy, unspecified	0.387	0.613	0.000
M43.8 Other specified deforming dorsopathies	0.387	0.613	0.000
M43.5 Other recurrent vertebral subluxation	0.387	0.613	0.000
M43.4 Other recurrent atlantoaxial subluxation	0.387	0.613	0.000
M43.3 Recurrent atlantoaxial subluxation with myelopathy	0.387	0.613	0.000
M43.2 Other fusion of spine	0.387	0.613	0.000
M48.5 Collapsed vertebra, not elsewhere classified	0.387	0.613	0.000
M85.65 Other cyst of bone (Pelvic region and thigh)	0.385	0.615	0.000
M62.85 Other specified disorders of muscle (Pelvic region and thigh)	0.385	0.615	0.000
M06 Other rheumatoid arthritis	0.379	0.621	0.000
M79.5 Residual foreign body in soft tissue	0.378	0.622	0.000
M84.0 Malunion of fracture	0.377	0.623	0.000
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)	0.376	0.623	0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)	0.376	0.623	0.000
M45.X6 Ankylosing spondylitis (Lumbar region)	0.376	0.623	0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)	0.376	0.623	0.000
M45.X4 Ankylosing spondylitis (Thoracic region)	0.376	0.623	0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)	0.376	0.623	0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)	0.376	0.623	0.000
M54.59 Low back pain (Site unspecified)	0.376	0.624	0.000
M85.0 Fibrous dysplasia (monostotic)	0.376	0.624	0.000
M48.9 Spondylopathy, unspecified	0.375	0.625	0.000
M48.8 Other specified spondylopathies	0.375	0.625	0.000
M48.4 Fatigue fracture of vertebra	0.375	0.625	0.000
M48.3 Traumatic spondylopathy	0.375	0.625	0.000
M48.2 Kissing spine	0.375	0.625	0.000
M48.1 Ankylosing hyperostosis [Forestier]	0.375	0.625	0.000
M14.6 Neuropathic arthropathy	0.375	0.625	0.000
M47.80 Other spondylosis (Multiple sites in spine)	0.373	0.627	0.000
M43.0 Spondylolysis	0.372	0.627	0.000
M86.6 Other chronic osteomyelitis	0.372	0.628	0.000
M79.2 Neuralgia and neuritis, unspecified	0.372	0.628	0.000
M53.39 Sacrococcygeal disorders, not elsewhere classified-Site uns	0.371	0.628	0.000
M53.37 Sacrococcygeal disorders, not elsewhere classified-Lumbosac	0.371	0.628	0.000
M53.36 Sacrococcygeal disorders, not elsewhere classified-Lumbar	0.371	0.628	0.000
M53.35 Sacrococcygeal disorders, not elsewhere classified-Thoracol	0.371	0.628	0.000
M53.34 Sacrococcygeal disorders, not elsewhere classified-Thoracic	0.371	0.628	0.000
M53.33 Sacrococcygeal disorders, not elsewhere classified-Cervicot	0.371	0.628	0.000
M53.32 Sacrococcygeal disorders, not elsewhere classified-Cervical	0.371	0.628	0.000
M53.31 Sacrococcygeal disorders, not elsewhere classified-Occipit-	0.371	0.628	0.000
M53.30 Sacrococcygeal disorders, not elsewhere classified-Mult sit	0.371	0.628	0.000
M85.87 Other specified disorders of bone density and structure (Ankle and foot)	0.370	0.629	0.000
M85.86 Other specified disorders of bone density and structure (Lower leg)	0.370	0.629	0.000
M85.84 Other specified disorders of bone density and structure (Hand)	0.370	0.629	0.000
M85.83 Other specified disorders of bone density and structure (Forearm)	0.370	0.629	0.000
M85.82 Other specified disorders of bone density and structure (Upper arm)	0.370	0.629	0.000
M85.81 Other specified disorders of bone density and structure (Shoulder region)	0.370	0.629	0.000
M46.8 Other specified inflammatory spondylopathies	0.370	0.630	0.000
M46.5 Other infective spondylopathies	0.370	0.630	0.000
M46.3 Infection of intervertebral disk (pyogenic)	0.370	0.630	0.000
M46.2 Osteomyelitis of vertebra	0.370	0.630	0.000
M46.1 Sacro-iliitis, not elsewhere classified	0.370	0.630	0.000
M46.0 Spinal enthesopathy	0.370	0.630	0.000
M84.37 Stress fracture, not elsewhere classified (Ankle and foot)	0.370	0.630	0.000
M91-M94 Chondropathies	0.369	0.631	0.000
M71 Other bursopathies	0.369	0.631	0.000
M88 Paget's disease of bone [osteitis deformans]	0.369	0.631	0.000
M41.5 Other secondary scoliosis	0.368	0.632	0.000
M41.4 Neuromuscular scoliosis	0.368	0.632	0.000
M41.3 Thoracogenic scoliosis	0.368	0.632	0.000
M41.2 Other idiopathic scoliosis	0.368	0.632	0.000
M41.1 Juvenile idiopathic scoliosis	0.368	0.632	0.000
M41.0 Infantile idiopathic scoliosis	0.368	0.632	0.000
M48.02 Spinal stenosis (Cervical region)	0.367	0.633	0.000
M47.9 Spondylosis, unspecified	0.364	0.636	0.000
M80.5 Idiopathic osteoporosis with pathological fracture	0.363	0.637	0.000
M72 Fibroblastic disorders	0.363	0.637	0.000
M40.5 Lordosis, unspecified	0.362	0.638	0.000
M49.8 Spondylopathy in other diseases classified elsewhere	0.362	0.638	0.000
M49.4 Neuropathic spondylopathy	0.362	0.638	0.000
M49.3 Spondylopathy in other infectious and parasitic diseases classified elsewhere	0.362	0.638	0.000
M49.2 Enterobacterial spondylitis	0.362	0.638	0.000
M49.1 Brucella spondylitis	0.362	0.638	0.000
M49.0 Tuberculosis of spine	0.362	0.638	0.000
M13.96 Arthritis, unspecified (Lower leg)	0.362	0.638	0.000
M65-M68 Disorders of synovium and tendon	0.362	0.638	0.000
M46.4 Discitis, unspecified	0.362	0.638	0.000
M54.69 Pain in thoracic spine-Site unspe	0.361	0.638	0.000
M54.68 Pain in thoracic spine-Sacral/sacrococ	0.361	0.638	0.000
M54.67 Pain in thoracic spine-Lumbosacral	0.361	0.638	0.000
M54.66 Pain in thoracic spine-Lumbar	0.361	0.638	0.000
M54.65 Pain in thoracic spine (Thoracolumbar region)	0.361	0.638	0.000
M54.63 Pain in thoracic spine (Cervicothoracic region)	0.361	0.638	0.000
M54.62 Pain in thoracic spine-Cervical	0.361	0.638	0.000
M54.61 Pain in thoracic spine-Occipit-atl-axl	0.361	0.638	0.000
M54.60 Pain in thoracic spine (Multiple sites in spine)	0.361	0.638	0.000
M47.1 Other spondylosis with myelopathy	0.361	0.638	0.000
M79.9 Soft tissue disorder, unspecified	0.361	0.639	0.000
M76 Enthesopathies of lower limb, excluding foot	0.361	0.639	0.000
M13.90 Arthritis, unspecified (Multiple sites)	0.361	0.639	0.000
M73 Soft tissue disorders in diseases classified elsewhere	0.361	0.639	0.000
M90 Osteopathies in diseases classified elsewhere	0.360	0.640	0.000
M47.99 Spondylosis, unspecified (Site unspecified)	0.360	0.640	0.000
M79.80 Other specified soft tissue disorders (Multiple sites)	0.359	0.641	0.000
M85.88 Other specified disorders of bone density and structure (Other)	0.358	0.641	0.000
M87 Osteonecrosis	0.358	0.642	0.000
M62.87 Other specified disorders of muscle (Ankle and foot)	0.357	0.642	0.000
M62.84 Other specified disorders of muscle (Hand)	0.357	0.642	0.000
M62.83 Other specified disorders of muscle (Forearm)	0.357	0.642	0.000
M62.59 Muscle wasting and atrophy, not elsewhere classified (Site unspecified)	0.357	0.643	0.000
M84.15 Nonunion of fracture [pseudarthrosis] (Pelvic region and thigh)	0.356	0.644	0.000
M79.0 Rheumatism, unspecified	0.355	0.645	0.000
M62.89 Other specified disorders of muscle (Site unspecified)	0.354	0.646	0.000
M84.48 Pathological fracture, not elsewhere classified (Other)	0.354	0.646	0.000
M41.96 Scoliosis, unspecified (Lumbar region)	0.354	0.646	0.000
M79.87 Other specified soft tissue disorders (Ankle and foot)	0.353	0.647	0.000
M45.X2 Ankylosing spondylitis (Cervical region)	0.353	0.647	0.000
M14.8 Arthropathies in other specified diseases classified elsewhere	0.352	0.647	0.000
M14.5 Arthropathies in other endocrine, nutritional and metabolic disorders	0.352	0.647	0.000
M14.4 Arthropathy in amyloidosis	0.352	0.647	0.000
M14.3 Lipoid dermatoarthritis	0.352	0.647	0.000
M14.2 Diabetic arthropathy	0.352	0.647	0.000
M14.1 Crystal arthropathy in other metabolic disorders	0.352	0.647	0.000
M14.0 Gouty arthropathy due to enzyme defects and other inherited disorders	0.352	0.647	0.000
M43.18 Spondylolisthesis (Sacral and sacrococcygeal region)	0.350	0.649	0.000
M43.15 Spondylolisthesis (Thoracolumbar region)	0.350	0.649	0.000
M43.14 Spondylolisthesis (Thoracic region)	0.350	0.649	0.000
M43.13 Spondylolisthesis (Cervicothoracic region)	0.350	0.649	0.000
M43.11 Spondylolisthesis (Occipito-atlanto-axial region)	0.350	0.649	0.000
M43.10 Spondylolisthesis (Multiple sites in spine)	0.350	0.649	0.000
M81 Osteoporosis without pathological fracture	0.350	0.650	0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.350	0.650	0.000
M47.0 Anterior spinal and vertebral artery compression syndromes	0.349	0.650	0.000
M54.55 Low back pain (Thoracolumbar region)	0.349	0.651	0.000
M43.12 Spondylolisthesis (Cervical region)	0.349	0.651	0.000
M49.54 Collapsed vertebra in diseases classified elsewhere (Thoracic region)	0.349	0.651	0.000
M79.88 Other specified soft tissue disorders (Other)	0.347	0.653	0.000
M62.58 Muscle wasting and atrophy, not elsewhere classified (Other)	0.346	0.654	0.000
M62.57 Muscle wasting and atrophy, not elsewhere classified (Ankle and foot)	0.346	0.654	0.000
M62.55 Muscle wasting and atrophy, not elsewhere classified (Pelvic region and thigh)	0.346	0.654	0.000
M62.54 Muscle wasting and atrophy, not elsewhere classified (Hand)	0.346	0.654	0.000
M62.53 Muscle wasting and atrophy, not elsewhere classified (Forearm)	0.346	0.654	0.000
M62.52 Muscle wasting and atrophy, not elsewhere classified (Upper arm)	0.346	0.654	0.000
M62.51 Muscle wasting and atrophy, not elsewhere classified (Shoulder region)	0.346	0.654	0.000
M62.50 Muscle wasting and atrophy, not elsewhere classified (Multiple sites)	0.346	0.654	0.000
M54.4 Lumbago with sciatica	0.345	0.654	0.000
M86.9 Osteomyelitis, unspecified	0.346	0.654	0.000
M12.2 Villonodular synovitis (pigmented)	0.345	0.655	0.000
M13.0 Polyarthritis, unspecified	0.344	0.656	0.000
M85.80 Other specified disorders of bone density and structure (Multiple sites)	0.344	0.656	0.000
M80.9 Unspecified osteoporosis with pathological fracture	0.342	0.657	0.001
M12.8 Other specific arthropathies, not elsewhere classified	0.340	0.660	0.000
M12.5 Traumatic arthropathy	0.340	0.660	0.000
M12.4 Intermittent hydrarthrosis	0.340	0.660	0.000
M12.3 Palindromic rheumatism	0.340	0.660	0.000
M12.1 Kaschin-Beck disease	0.340	0.660	0.000
M12.0 Chronic postrheumatic arthropathy [Jaccoud]	0.340	0.660	0.000
M80.8 Other osteoporosis with pathological fracture	0.339	0.661	0.000
M13.19 Monoarthritis, not elsewhere classified (Site unspecified)	0.338	0.662	0.000
M13.18 Monoarthritis, not elsewhere classified (Other)	0.338	0.662	0.000
M13.17 Monoarthritis, not elsewhere classified (Ankle and foot)	0.338	0.662	0.000
M13.16 Monoarthritis, not elsewhere classified (Lower leg)	0.338	0.662	0.000
M13.15 Monoarthritis, not elsewhere classified (Pelvic region and thigh)	0.338	0.662	0.000
M13.14 Monoarthritis, not elsewhere classified (Hand)	0.338	0.662	0.000
M13.13 Monoarthritis, not elsewhere classified (Forearm)	0.338	0.662	0.000
M13.12 Monoarthritis, not elsewhere classified (Upper arm)	0.338	0.662	0.000
M13.11 Monoarthritis, not elsewhere classified (Shoulder region)	0.338	0.662	0.000
M13.10 Monoarthritis, not elsewhere classified (Multiple sites)	0.338	0.662	0.000
M89.5 Osteolysis	0.338	0.662	0.000
M13.80 Other specified arthritis (Multiple sites)	0.337	0.663	0.000
M84.19 Nonunion of fracture [pseudarthrosis] (Site unspecified)	0.337	0.663	0.000
M84.10 Nonunion of fracture [pseudarthrosis] (Multiple sites)	0.337	0.663	0.000
M08.9 Juvenile arthritis, unspecified	0.336	0.664	0.000
M08.8 Other juvenile arthritis	0.336	0.664	0.000
M08.4 Pauciarticular juvenile arthritis	0.336	0.664	0.000
M08.3 Juvenile polyarthritis (seronegative)	0.336	0.664	0.000
M08.2 Juvenile arthritis with systemic onset	0.336	0.664	0.000
M08.1 Juvenile ankylosing spondylitis	0.336	0.664	0.000
M08.0 Juvenile rheumatoid arthritis	0.336	0.664	0.000
M09.8 Juvenile arthritis in other diseases classified elsewhere	0.336	0.664	0.000
M09.2 Juvenile arthritis in ulcerative colitis	0.336	0.664	0.000
M09.1 Juvenile arthritis in Crohn's disease [regional enteritis]	0.336	0.664	0.000
M09.0 Juvenile arthritis in psoriasis	0.336	0.664	0.000
M89.04 Algoneurodystrophy (Hand)	0.336	0.664	0.000
M85.67 Other cyst of bone (Ankle and foot)	0.336	0.664	0.000
M43.19 Spondylolisthesis (Site unspecified)	0.336	0.664	0.000
M54.9 Dorsalgia, unspecified	0.335	0.665	0.000
M79.3 Panniculitis, unspecified	0.334	0.665	0.000
M40.4 Other lordosis	0.333	0.667	0.000
M40.3 Flatback syndrome	0.333	0.667	0.000
M40.1 Other secondary kyphosis	0.333	0.667	0.000
M40.0 Postural kyphosis	0.333	0.667	0.000
M13.88 Other specified arthritis (Other)	0.333	0.667	0.000
M13.87 Other specified arthritis (Ankle and foot)	0.333	0.667	0.000
M13.86 Other specified arthritis (Lower leg)	0.333	0.667	0.000
M13.85 Other specified arthritis (Pelvic region and thigh)	0.333	0.667	0.000
M13.84 Other specified arthritis (Hand)	0.333	0.667	0.000
M13.83 Other specified arthritis (Forearm)	0.333	0.667	0.000
M13.82 Other specified arthritis (Upper arm)	0.333	0.667	0.000
M13.81 Other specified arthritis (Shoulder region)	0.333	0.667	0.000
M85.69 Other cyst of bone (Site unspecified)	0.332	0.668	0.000
M85.68 Other cyst of bone (Other)	0.332	0.668	0.000
M85.66 Other cyst of bone (Lower leg)	0.332	0.668	0.000
M85.64 Other cyst of bone (Hand)	0.332	0.668	0.000
M85.63 Other cyst of bone (Forearm)	0.332	0.668	0.000
M85.62 Other cyst of bone (Upper arm)	0.332	0.668	0.000
M85.61 Other cyst of bone (Shoulder region)	0.332	0.668	0.000
M85.60 Other cyst of bone (Multiple sites)	0.332	0.668	0.000
M80.4 Drug-induced osteoporosis with pathological fracture	0.332	0.668	0.000
M80.3 Postsurgical malabsorption osteoporosis with pathological fracture	0.332	0.668	0.000
M80.2 Osteoporosis of disuse with pathological fracture	0.332	0.668	0.000
M54.17 Radiculopathy (Lumbosacral region)	0.332	0.668	0.000
M79.28 Neuralgia and neuritis, unspecified (Other)	0.329	0.671	0.000
M86.8 Other osteomyelitis	0.329	0.671	0.000
M79.4 Hypertrophy of (infrapatellar) fat pad	0.328	0.672	0.000
M79.81 Other specified soft tissue disorders (Shoulder region)	0.327	0.673	0.000
M89.8 Other specified disorders of bone	0.326	0.674	0.000
M40.2 Other and unspecified kyphosis	0.326	0.674	0.000
M70.4 Prepatellar bursitis	0.326	0.674	0.000
M86.5 Other chronic haematogenous osteomyelitis	0.324	0.676	0.000
M86.4 Chronic osteomyelitis with draining sinus	0.324	0.676	0.000
M86.3 Chronic multifocal osteomyelitis	0.324	0.676	0.000
M86.2 Subacute osteomyelitis	0.324	0.676	0.000
M86.1 Other acute osteomyelitis	0.324	0.676	0.000
M86.0 Acute haematogenous osteomyelitis	0.324	0.676	0.000
I22.9 Subsequent myocardial infarction of unspecified site	0.000	0.677	0.323
M41.97 Scoliosis, unspecified (Lumbosacral region)	0.322	0.677	0.000
M54.12 Radiculopathy (Cervical region)	0.322	0.678	0.000
M79.7 Fibromyalgia	0.322	0.678	0.000
M46.97 Inflammatory spondylopathy, unspecified (Lumbosacral region)	0.322	0.678	0.000
M13.89 Other specified arthritis (Site unspecified)	0.321	0.678	0.000
M41.86 Other forms of scoliosis (Lumbar region)	0.321	0.679	0.000
M62.86 Other specified disorders of muscle (Lower leg)	0.321	0.679	0.000
M84.39 Stress fracture, not elsewhere classified (Site unspecified)	0.320	0.679	0.000
M84.38 Stress fracture, not elsewhere classified (Other)	0.320	0.679	0.000
M84.36 Stress fracture, not elsewhere classified (Lower leg)	0.320	0.679	0.000
M84.35 Stress fracture, not elsewhere classified (Pelvic region and thigh)	0.320	0.679	0.000
M84.34 Stress fracture, not elsewhere classified (Hand)	0.320	0.679	0.000
M84.33 Stress fracture, not elsewhere classified (Forearm)	0.320	0.679	0.000
M84.32 Stress fracture, not elsewhere classified (Upper arm)	0.320	0.679	0.000
M84.31 Stress fracture, not elsewhere classified (Shoulder region)	0.320	0.679	0.000
M84.30 Stress fracture, not elsewhere classified (Multiple sites)	0.320	0.679	0.000
M83.9 Adult osteomalacia, unspecified	0.320	0.680	0.000
M83.8 Other adult osteomalacia	0.320	0.680	0.000
M83.5 Other drug-induced osteomalacia in adults	0.320	0.680	0.000
M83.4 Aluminum bone disease	0.320	0.680	0.000
M83.3 Adult osteomalacia due to malnutrition	0.320	0.680	0.000
M83.2 Adult osteomalacia due to malabsorption	0.320	0.680	0.000
M83.1 Senile osteomalacia	0.320	0.680	0.000
M83.0 Puerperal osteomalacia	0.320	0.680	0.000
M47.86 Other spondylosis (Lumbar region)	0.320	0.680	0.000
M80.0 Postmenopausal osteoporosis with pathological fracture	0.318	0.682	0.000
M80.98 Unspecified osteoporosis with pathological fracture (Other)	0.318	0.682	0.000
M79.09 Rheumatism, unspecified (Site unspecified)	0.318	0.682	0.000
M42.9 Spinal osteochondrosis, unspecified	0.316	0.684	0.000
M42.1 Adult osteochondrosis of spine	0.316	0.684	0.000
M42.0 Juvenile osteochondrosis of spine	0.316	0.684	0.000
M03 Postinfective and reactive arthropathies in diseases classified elsewhere	0.316	0.684	0.000
M02 Reactive arthropathies	0.316	0.684	0.000
M01 Direct infections of joint in infectious and parasitic diseases classified elsewhere	0.316	0.684	0.000
M54.09 Panniculitis affecting regions of neck and back (Site unspecified)	0.316	0.684	0.000
M54.08 Panniculitis affecting regions of neck and back (Sacral and sacrococcygeal region)	0.316	0.684	0.000
M54.07 Panniculitis affecting regions of neck and back (Lumbosacral region)	0.316	0.684	0.000
M54.06 Panniculitis affecting regions of neck and back (Lumbar region)	0.316	0.684	0.000
M54.05 Panniculitis affecting regions of neck and back (Thoracolumbar region)	0.316	0.684	0.000
M54.04 Panniculitis affecting regions of neck and back (Thoracic region)	0.316	0.684	0.000
M54.03 Panniculitis affecting regions of neck and back (Cervicothoracic region)	0.316	0.684	0.000
M54.02 Panniculitis affecting regions of neck and back (Cervical region)	0.316	0.684	0.000
M54.01 Panniculitis affecting regions of neck and back (Occipito-atlanto-axial region)	0.316	0.684	0.000
M54.00 Panniculitis affecting regions of neck and back (Multiple sites in spine)	0.316	0.684	0.000
M48.56 Collapsed vertebra, not elsewhere classified (Lumbar region)	0.315	0.684	0.000
M70.7 Other bursitis of hip	0.315	0.684	0.000
M48.08 Spinal stenosis (Sacral and sacrococcygeal region)	0.315	0.685	0.000
M48.05 Spinal stenosis (Thoracolumbar region)	0.315	0.685	0.000
M48.04 Spinal stenosis (Thoracic region)	0.315	0.685	0.000
M48.03 Spinal stenosis (Cervicothoracic region)	0.315	0.685	0.000
M48.01 Spinal stenosis (Occipito-atlanto-axial region)	0.315	0.685	0.000
M82.8 Osteoporosis in other diseases classified elsewhere	0.314	0.685	0.000
M82.0 Osteoporosis in multiple myelomatosis	0.314	0.685	0.000
M82.3 Osteoporosis in diseases classified elsewhere, Forearm	0.314	0.685	0.000
M84.49 Pathological fracture, not elsewhere classified (Site unspecified)	0.314	0.686	0.000
M84.47 Pathological fracture, not elsewhere classified (Ankle and foot)	0.314	0.686	0.000
M84.46 Pathological fracture, not elsewhere classified (Lower leg)	0.314	0.686	0.000
M84.45 Pathological fracture, not elsewhere classified (Pelvic region and thigh)	0.314	0.686	0.000
M84.44 Pathological fracture, not elsewhere classified (Hand)	0.314	0.686	0.000
M84.43 Pathological fracture, not elsewhere classified (Forearm)	0.314	0.686	0.000
M84.42 Pathological fracture, not elsewhere classified (Upper arm)	0.314	0.686	0.000
M84.41 Pathological fracture, not elsewhere classified (Shoulder region)	0.314	0.686	0.000
M84.40 Pathological fracture, not elsewhere classified (Multiple sites)	0.314	0.686	0.000
M77 Other enthesopathies	0.314	0.686	0.000
M89.6 Osteopathy after poliomyelitis	0.313	0.686	0.000
M89.4 Other hypertrophic osteo-arthropathy	0.313	0.686	0.000
M89.2 Other disorders of bone development and growth	0.313	0.686	0.000
M89.1 Epiphyseal arrest	0.313	0.686	0.000
M46.98 Inflammatory spondylopathy, unspecified (Sacral and sacrococcygeal region)	0.313	0.687	0.000
M46.95 Inflammatory spondylopathy, unspecified (Thoracolumbar region)	0.313	0.687	0.000
M46.94 Inflammatory spondylopathy, unspecified (Thoracic region)	0.313	0.687	0.000
M46.93 Inflammatory spondylopathy, unspecified (Cervicothoracic region)	0.313	0.687	0.000
M46.91 Inflammatory spondylopathy, unspecified (Occipito-atlanto-axial region)	0.313	0.687	0.000
M15-M19 Arthrosis	0.312	0.688	0.000
M06.3 Rheumatoid nodule	0.311	0.689	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations