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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2238151
log Bayes Factor = 27.2496
Chromosome 12   position 112,211,833  (GRCh37) Explore rs2238151 on Ensembl!
Variant rs2238151 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
I21 Acute myocardial infarction
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.000 1.000
Z95.5 Presence of coronary angioplasty implant and graft
0.000 0.001 0.999
Z95 Presence of cardiac and vascular implants and grafts
0.000 0.002 0.998
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.004 0.996
C77.3 Axillary and upper limb lymph nodes
0.989 0.011 0.000
I22 Subsequent myocardial infarction
0.000 0.025 0.975
Z95.4 Presence of other heart-valve replacement
0.000 0.026 0.974
Z95.2 Presence of prosthetic heart valve
0.000 0.036 0.964
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.058 0.942
I30-I52 Other forms of heart disease
0.000 0.070 0.930
Chapter IX Diseases of the circulatory system
0.000 0.071 0.929
I21.9 Acute myocardial infarction, unspecified
0.000 0.074 0.926
Z95.3 Presence of xenogenic heart valve
0.000 0.080 0.920
I42 Cardiomyopathy
0.000 0.084 0.916
I49 Other cardiac arrhythmias
0.000 0.085 0.915
I49.9 Cardiac arrhythmia, unspecified
0.000 0.085 0.915
Z95.8 Presence of other cardiac and vascular implants and grafts
0.000 0.104 0.896
I25.5 Ischaemic cardiomyopathy
0.000 0.107 0.893
I50 Heart failure
0.000 0.109 0.891
I50.1 Left ventricular failure
0.000 0.128 0.872
I42.9 Cardiomyopathy, unspecified
0.000 0.128 0.872
I42.0 Dilated cardiomyopathy
0.000 0.138 0.862
Z95.0 Presence of cardiac pacemaker
0.000 0.155 0.845
I36 Nonrheumatic tricuspid valve disorders
0.000 0.167 0.833
I95-I99 Other and unspecified disorders of the circulatory system
0.000 0.182 0.818
I42.1 Obstructive hypertrophic cardiomyopathy
0.000 0.185 0.815
I22.8 Subsequent myocardial infarction of other sites
0.000 0.196 0.804
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.200 0.800
I37 Pulmonary valve disorders
0.000 0.205 0.795
I23 Certain current complications following acute myocardial infarction
0.000 0.209 0.790
I38 Endocarditis, valve unspecified
0.000 0.211 0.789
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.214 0.786
I25.2 Old myocardial infarction
0.000 0.234 0.766
I36.1 Nonrheumatic tricuspid (valve) insufficiency
0.000 0.236 0.764
I25.4 Coronary artery aneurysm
0.000 0.240 0.760
I99 Other and unspecified disorders of circulatory system
0.000 0.245 0.755
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.251 0.749
E03 Other hypothyroidism
0.000 0.252 0.748
I21.4 Acute subendocardial myocardial infarction
0.000 0.255 0.745
Z95.9 Presence of cardiac and vascular implant and graft, unspecified
0.000 0.255 0.745
I49.3 Ventricular premature depolarisation
0.000 0.261 0.739
I42.6 Alcoholic cardiomyopathy
0.000 0.262 0.738
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.000 0.263 0.737
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.263 0.737
I10-I15 Hypertensive diseases
0.000 0.275 0.725
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.291 0.709
I35 Nonrheumatic aortic valve disorders
0.000 0.296 0.704
I49.0 Ventricular fibrillation and flutter
0.000 0.297 0.703
I37.1 Pulmonary valve insufficiency
0.000 0.297 0.703
I26 Pulmonary embolism
0.000 0.310 0.690
I10 Essential (primary) hypertension
0.000 0.311 0.689
I31 Other diseases of pericardium
0.000 0.313 0.687
I35.2 Aortic (valve) stenosis with insufficiency
0.000 0.326 0.674
I26.9 Pulmonary embolism without mention of acute cor pulmonale
0.000 0.332 0.668
I52 Other heart disorders in diseases classified elsewhere
0.000 0.333 0.667
I48 Atrial fibrillation and flutter
0.000 0.333 0.667
I41 Myocarditis in diseases classified elsewhere
0.000 0.333 0.667
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.000 0.333 0.667
I32 Pericarditis in diseases classified elsewhere
0.000 0.333 0.667
I43 Cardiomyopathy in diseases classified elsewhere
0.000 0.341 0.659
I40 Acute myocarditis
0.000 0.342 0.658
I42.5 Other restrictive cardiomyopathy
0.000 0.343 0.657
I42.4 Endocardial fibroelastosis
0.000 0.343 0.657
I42.3 Endomyocardial (eosinophilic) disease
0.000 0.343 0.657
I97.1 Other functional disturbances following cardiac surgery
0.000 0.344 0.656
I49.2 Junctional premature depolarisation
0.000 0.344 0.656
I50.0 Congestive heart failure
0.000 0.346 0.654
I23.8 Other current complications following acute myocardial infarction
0.000 0.360 0.640
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.369 0.631
I25.3 Aneurysm of heart
0.000 0.376 0.624
I45 Other conduction disorders
0.000 0.379 0.621
I49.5 Sick sinus syndrome
0.000 0.380 0.620
C90.0 Multiple myeloma
0.616 0.384 0.000
C90 Multiple myeloma and malignant plasma cell neoplasms
0.615 0.385 0.000
E03.8 Other specified hypothyroidism
0.000 0.394 0.606
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.605 0.395 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.395 0.605
I97.8 Other postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.399 0.601
I36.9 Nonrheumatic tricuspid valve disorder, unspecified
0.000 0.403 0.597
I36.8 Other nonrheumatic tricuspid valve disorders
0.000 0.403 0.597
I36.2 Nonrheumatic tricuspid (valve) stenosis with insufficiency
0.000 0.403 0.597
I36.0 Nonrheumatic tricuspid (valve) stenosis
0.000 0.403 0.597
I00-I02 Acute rheumatic fever
0.000 0.408 0.592
C77 Secondary and unspecified malignant neoplasm of lymph nodes
0.590 0.410 0.000
I97.2 Postmastectomy lymphoedema syndrome
0.000 0.411 0.588
I20 Angina pectoris
0.000 0.420 0.580
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.423 0.577
C84 Peripheral and cutaneous T-cell lymphomas
0.573 0.427 0.000
C77.4 Inguinal and lower limb lymph nodes
0.571 0.429 0.000
I37.9 Pulmonary valve disorder, unspecified
0.000 0.430 0.570
I37.8 Other pulmonary valve disorders
0.000 0.430 0.570
I37.2 Pulmonary valve stenosis with insufficiency
0.000 0.430 0.570
Chapter II Neoplasms
0.570 0.430 0.000
Z95.1 Presence of aortocoronary bypass graft
0.000 0.431 0.569
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.569 0.431 0.000
I31.0 Chronic adhesive pericarditis
0.000 0.433 0.567
C50 Malignant neoplasm of breast
0.567 0.433 0.000
C50-C50 Malignant neoplasm of breast
0.567 0.433 0.000
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.433 0.567
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.433 0.567
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.433 0.567
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.433 0.567
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.433 0.567
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.433 0.567
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.433 0.567
E00-E07 Disorders of thyroid gland
0.000 0.435 0.565
I45.9 Conduction disorder, unspecified
0.000 0.441 0.559
I37.0 Pulmonary valve stenosis
0.000 0.443 0.557
I44 Atrioventricular and left bundle-branch block
0.000 0.449 0.551
I73 Other peripheral vascular diseases
0.000 0.450 0.550
I45.4 Nonspecific intraventricular block
0.000 0.455 0.545
I31.1 Chronic constrictive pericarditis
0.000 0.455 0.545
C95 Leukaemia of unspecified cell type
0.539 0.461 0.000
C90.2 Plasmacytoma, extramedullary
0.539 0.461 0.000
I97.9 Postprocedural disorder of circulatory system, unspecified
0.000 0.463 0.537
I97.0 Postcardiotomy syndrome
0.000 0.463 0.537
E03.5 Myxoedema coma
0.000 0.464 0.536
E03.4 Atrophy of thyroid (acquired)
0.000 0.464 0.536
E03.3 Postinfectious hypothyroidism
0.000 0.464 0.536
I15 Secondary hypertension
0.000 0.466 0.534
C50.4 Upper-outer quadrant of breast
0.531 0.469 0.000
C50.0 Nipple and areola
0.530 0.470 0.000
C50.1 Central portion of breast
0.526 0.474 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.523 0.477 0.000
I49.1 Atrial premature depolarisation
0.000 0.478 0.522
C50.8 Overlapping lesion of breast
0.522 0.478 0.000
I13 Hypertensive heart and renal disease
0.000 0.480 0.520
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.519 0.481 0.000
C81 Hodgkin's disease
0.518 0.482 0.000
E03.1 Congenital hypothyroidism without goitre
0.000 0.484 0.516
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.484 0.516
I35.0 Aortic (valve) stenosis
0.000 0.485 0.515
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.485 0.515
I42.8 Other cardiomyopathies
0.000 0.487 0.513
I44.6 Other and unspecified fascicular block
0.000 0.490 0.510
I28 Other diseases of pulmonary vessels
0.000 0.491 0.509
I45.6 Preexcitation syndrome
0.000 0.491 0.509
I20.8 Other forms of angina pectoris
0.000 0.492 0.508
C90.1 Plasma cell leukaemia
0.507 0.493 0.000
I33 Acute and subacute endocarditis
0.000 0.494 0.506
I73.9 Peripheral vascular disease, unspecified
0.000 0.495 0.505
C64-C68 Malignant neoplasms of urinary tract
0.505 0.495 0.000
I42.2 Other hypertrophic cardiomyopathy
0.000 0.500 0.500
I98 Other disorders of circulatory system in diseases classified elsewhere
0.000 0.500 0.500
I50.9 Heart failure, unspecified
0.000 0.501 0.499
C50.9 Breast, unspecified
0.499 0.501 0.000
I40.9 Acute myocarditis, unspecified
0.000 0.502 0.498
I42.7 Cardiomyopathy due to drugs and other external agents
0.000 0.505 0.494
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.494 0.506 0.000
I30 Acute pericarditis
0.000 0.506 0.494
C92 Myeloid leukaemia
0.494 0.506 0.000
I31.8 Other specified diseases of pericardium
0.000 0.507 0.493
I31.2 Haemopericardium, not elsewhere classified
0.000 0.507 0.493
C64 Malignant neoplasm of kidney, except renal pelvis
0.493 0.507 0.000
I45.2 Bifascicular block
0.000 0.510 0.490
E10 Insulin-dependent diabetes mellitus
0.000 0.510 0.490
I78 Diseases of capillaries
0.000 0.510 0.490
E10.3 With ophthalmic complications
0.000 0.512 0.488
C69 Malignant neoplasm of eye and adnexa
0.486 0.514 0.000
C84.0 Mycosis fungoides
0.486 0.514 0.000
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.514 0.485
I47 Paroxysmal tachycardia
0.000 0.516 0.484
C84.5 Other and unspecified T-cell lymphomas
0.483 0.517 0.000
C84.4 Peripheral T-cell lymphoma
0.482 0.518 0.000
C49 Malignant neoplasm of other connective and soft tissue
0.481 0.519 0.000
E06 Thyroiditis
0.000 0.520 0.480
I32.8 Pericarditis in other diseases classified elsewhere
0.000 0.522 0.478
I32.1 Pericarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.522 0.478
I32.0 Pericarditis in bacterial diseases classified elsewhere
0.000 0.522 0.478
I39.8 Endocarditis, valve unspecified, in diseases classified elsewhere
0.000 0.522 0.478
I39.4 Multiple valve disorders in diseases classified elsewhere
0.000 0.522 0.478
I39.3 Pulmonary valve disorders in diseases classified elsewhere
0.000 0.522 0.478
I39.2 Tricuspid valve disorders in diseases classified elsewhere
0.000 0.522 0.478
I39.1 Aortic valve disorders in diseases classified elsewhere
0.000 0.522 0.478
I39.0 Mitral valve disorders in diseases classified elsewhere
0.000 0.522 0.478
I41.8 Myocarditis in other diseases classified elsewhere
0.000 0.522 0.478
I41.2 Myocarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.522 0.478
I41.1 Myocarditis in viral diseases classified elsewhere
0.000 0.522 0.478
I41.0 Myocarditis in bacterial diseases classified elsewhere
0.000 0.522 0.478
I48.9 Atrial fibrillation and atrial flutter, unspecified
0.000 0.522 0.478
I48.4 Atypical atrial flutter
0.000 0.522 0.478
I48.3 Typical atrial flutter
0.000 0.522 0.478
I48.2 Chronic atrial fibrillation
0.000 0.522 0.478
I48.1 Persistent atrial fibrillation
0.000 0.522 0.478
I48.0 Paroxysmal atrial fibrillation
0.000 0.522 0.478
I52.8 Other heart disorders in other diseases classified elsewhere
0.000 0.522 0.478
I52.1 Other heart disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.522 0.478
I52.0 Other heart disorders in bacterial diseases classified elsewhere
0.000 0.522 0.478
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.477 0.523 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.525 0.475
C80 Malignant neoplasm without specification of site
0.474 0.526 0.000
C95.0 Acute leukaemia of unspecified cell type
0.473 0.527 0.000
I43.8 Cardiomyopathy in other diseases classified elsewhere
0.000 0.527 0.473
I43.2 Cardiomyopathy in nutritional diseases
0.000 0.527 0.473
I43.0 Cardiomyopathy in infectious and parasitic diseases classified elsewhere
0.000 0.527 0.473
I40.8 Other acute myocarditis
0.000 0.528 0.472
I40.1 Isolated myocarditis
0.000 0.528 0.472
I43.1 Cardiomyopathy in metabolic diseases
0.000 0.535 0.465
E10-E14 Diabetes mellitus
0.000 0.535 0.465
I15.1 Hypertension secondary to other renal disorders
0.000 0.537 0.463
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.000 0.541 0.459
E10.9 Without complications
0.000 0.541 0.459
I24 Other acute ischaemic heart diseases
0.000 0.541 0.459
E20-E35 Disorders of other endocrine glands
0.000 0.542 0.458
C45 Mesothelioma
0.457 0.543 0.000
C86 Other specified types of T/NK-cell lymphoma
0.455 0.545 0.000
C88 Malignant immunoproliferative diseases
0.453 0.547 0.000
C49.3 Connective and soft tissue of thorax
0.451 0.549 0.000
I51 Complications and ill-defined descriptions of heart disease
0.000 0.550 0.449
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.551 0.449
I05-I09 Chronic rheumatic heart diseases
0.000 0.551 0.449
E07 Other disorders of thyroid
0.000 0.552 0.448
I45.0 Right fascicular block
0.000 0.554 0.445
C32 Malignant neoplasm of larynx
0.445 0.555 0.000
I45.8 Other specified conduction disorders
0.000 0.557 0.443
I31.3 Pericardial effusion (noninflammatory)
0.000 0.557 0.443
C81.0 Lymphocytic predominance
0.441 0.559 0.000
C97 Malignant neoplasms of independent (primary) multiple sites
0.441 0.559 0.000
C81.1 Nodular sclerosis
0.437 0.563 0.000
C90.3 Solitary plasmacytoma
0.435 0.565 0.000
I73.8 Other specified peripheral vascular diseases
0.000 0.566 0.434
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.434 0.566 0.000
C94 Other leukaemias of specified cell type
0.434 0.566 0.000
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.433 0.567 0.000
I40.0 Infective myocarditis
0.000 0.568 0.432
C84.8 Cutaneous T-cell lymphoma, unspecified
0.431 0.568 0.000
C92.0 Acute myeloid leukaemia
0.430 0.570 0.000
E10.5 With peripheral circulatory complications
0.000 0.570 0.430
C95.9 Leukaemia, unspecified
0.429 0.571 0.000
C81.2 Mixed cellularity
0.429 0.571 0.000
I02 Rheumatic chorea
0.000 0.575 0.425
I01 Rheumatic fever with heart involvement
0.000 0.575 0.425
I77 Other disorders of arteries and arterioles
0.000 0.575 0.425
I78.0 Hereditary haemorrhagic telangiectasia
0.000 0.576 0.424
E23 Hypofunction and other disorders of pituitary gland
0.000 0.580 0.420
E06.9 Thyroiditis, unspecified
0.000 0.582 0.418
C80.9 Malignant neoplasm, unspecified
0.417 0.582 0.000
I44.4 Left anterior fascicular block
0.000 0.583 0.417
I47.2 Ventricular tachycardia
0.000 0.583 0.417
C93 Monocytic leukaemia
0.413 0.587 0.000
E27 Other disorders of adrenal gland
0.000 0.588 0.412
C84.9 Mature T/NK-cell lymphoma, unspecified
0.411 0.589 0.000
C84.7 Anaplastic large cell lymphoma, ALK-negative
0.411 0.589 0.000
C84.6 Anaplastic large cell lymphoma, ALK-positive
0.411 0.589 0.000
C84.3 Lymphoepithelioid lymphoma
0.411 0.589 0.000
C84.2 T-zone lymphoma
0.411 0.589 0.000
C84.1 Sezary's diease
0.411 0.589 0.000
I51.7 Cardiomegaly
0.000 0.589 0.411
C69.3 Choroid
0.410 0.590 0.000
C32.9 Larynx, unspecified
0.409 0.591 0.000
I26.0 Pulmonary embolism with mention of acute cor pulmonale
0.000 0.591 0.408
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.594 0.405
E00 Congenital iodine-deficiency syndrome
0.000 0.594 0.405
E10.2 With renal complications
0.000 0.595 0.405
C69.4 Ciliary body
0.405 0.595 0.000
C49.9 Connective and soft tissue, unspecified
0.405 0.595 0.000
I78.8 Other diseases of capillaries
0.000 0.598 0.402
C49.1 Connective and soft tissue of upper limb, including shoulder
0.401 0.599 0.000
I20.9 Angina pectoris, unspecified
0.000 0.599 0.401
C77.8 Lymph nodes of multiple regions
0.399 0.601 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.602 0.398
E10.0 With coma
0.000 0.603 0.397
C45.0 Mesothelioma of pleura
0.397 0.603 0.000
C65 Malignant neoplasm of renal pelvis
0.395 0.605 0.000
I44.5 Left posterior fascicular block
0.000 0.605 0.395
I35.9 Aortic valve disorder, unspecified
0.000 0.605 0.395
I73.1 Thromboangiitis obliterans [Buerger]
0.000 0.606 0.394
C76 Malignant neoplasm of other and ill-defined sites
0.392 0.608 0.000
E07.9 Disorder of thyroid, unspecified
0.000 0.608 0.392
C40-C41 Malignant neoplasms of bone and articular cartilage
0.392 0.608 0.000
I44.3 Other and unspecified atrioventricular block
0.000 0.609 0.391
E23.0 Hypopituitarism
0.000 0.612 0.388
C95.7 Other leukaemia of unspecified cell type
0.387 0.613 0.000
C95.2 Subacute leukaemia of unspecified cell type
0.387 0.613 0.000
C95.1 Chronic leukaemia of unspecified cell type
0.387 0.613 0.000
I15.8 Other secondary hypertension
0.000 0.617 0.383
I15.0 Renovascular hypertension
0.000 0.617 0.383
E10.8 With unspecified complications
0.000 0.617 0.383
C69.9 Eye, unspecified
0.382 0.618 0.000
I31.9 Disease of pericardium, unspecified
0.000 0.619 0.381
C69.6 Orbit
0.381 0.619 0.000
C32.0 Glottis
0.380 0.620 0.000
C92.4 Acute promyelocytic leukaemia
0.378 0.622 0.000
C88.4 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]
0.377 0.623 0.000
C31 Malignant neoplasm of accessory sinuses
0.377 0.623 0.000
I77.6 Arteritis, unspecified
0.000 0.624 0.376
C82.0 Small cleaved cell, follicular
0.375 0.625 0.000
C47 Malignant neoplasm of peripheral nerves and autonomic nervous system
0.375 0.625 0.000
C46 Kaposi's sarcoma
0.375 0.625 0.000
C71 Malignant neoplasm of brain
0.375 0.625 0.000
C50.6 Axillary tail of breast
0.375 0.625 0.000
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.627 0.373
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.627 0.373
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.627 0.373
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.627 0.373
I08 Multiple valve diseases
0.000 0.627 0.373
C70 Malignant neoplasm of meninges
0.372 0.627 0.000
C81.7 Other Hodgkin's disease
0.371 0.628 0.000
C81.4 Lymphocyte-rich classical Hodgkin lymphoma
0.371 0.628 0.000
C81.3 Lymphocytic depletion
0.371 0.628 0.000
C92.9 Myeloid leukaemia, unspecified
0.371 0.628 0.000
C45.7 Mesothelioma of other sites
0.369 0.630 0.000
I79.1 Aortitis in diseases classified elsewhere
0.000 0.631 0.369
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.000 0.631 0.369
I15.2 Hypertension secondary to endocrine disorders
0.000 0.634 0.366
I28.9 Disease of pulmonary vessels, unspecified
0.000 0.635 0.365
I28.1 Aneurysm of pulmonary artery
0.000 0.635 0.365
I28.0 Arteriovenous fistula of pulmonary vessels
0.000 0.635 0.365
C49.5 Connective and soft tissue of pelvis
0.364 0.636 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.636 0.364
E10.6 With other specified complications
0.000 0.637 0.363
I33.9 Acute endocarditis, unspecified
0.000 0.637 0.363
C69.0 Conjunctiva
0.363 0.637 0.000
E28 Ovarian dysfunction
0.000 0.638 0.362
I24.8 Other forms of acute ischaemic heart disease
0.000 0.638 0.362
I73.0 Raynaud's syndrome
0.000 0.638 0.362
E20 Hypoparathyroidism
0.000 0.641 0.359
C49.6 Connective and soft tissue of trunk, unspecified
0.359 0.641 0.000
I98.8 Other specified disorders of circulatory system in diseases classified elsewhere
0.000 0.641 0.358
I98.1 Cardiovascular disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.641 0.358
I98.0 Cardiovascular syphilis
0.000 0.641 0.358
E27.1 Primary adrenocortical insufficiency
0.000 0.642 0.358
C72 Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system
0.358 0.642 0.000
I51.9 Heart disease, unspecified
0.000 0.642 0.357
I30.8 Other forms of acute pericarditis
0.000 0.645 0.354
I30.0 Acute nonspecific idiopathic pericarditis
0.000 0.645 0.354
C92.8 Acute myeloid leukaemia with multilineage dysplasia
0.354 0.646 0.000
C92.7 Other myeloid leukaemia
0.354 0.646 0.000
C92.6 Acute myeloid leukaemia with 11q23-abnormality
0.354 0.646 0.000
C92.5 Acute myelomonocytic leukaemia
0.354 0.646 0.000
C92.3 Myeloid sarcoma
0.354 0.646 0.000
C92.2 Subacute myeloid leukaemia
0.354 0.646 0.000
C37 Malignant neoplasm of thymus
0.354 0.646 0.000
C82.2 Large cell, follicular
0.352 0.648 0.000
I78.9 Disease of capillaries, unspecified
0.000 0.649 0.351
I00 Rheumatic fever without mention of heart involvement
0.000 0.649 0.351
I30.1 Infective pericarditis
0.000 0.649 0.351
E25 Adrenogenital disorders
0.000 0.650 0.350
E06.5 Other chronic thyroiditis
0.000 0.651 0.349
C69.8 Overlapping lesion of eye and adnexa
0.349 0.651 0.000
C69.5 Lachrymal gland and duct
0.349 0.651 0.000
C69.2 Retina
0.349 0.651 0.000
C69.1 Cornea
0.349 0.651 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.348 0.652 0.000
I24.1 Dressler's syndrome
0.000 0.652 0.348
C86.5 Angioimmunoblastic T-cell lymphoma
0.348 0.652 0.000
E26 Hyperaldosteronism
0.000 0.654 0.346
I28.8 Other specified diseases of pulmonary vessels
0.000 0.654 0.346
C49.8 Overlapping lesion of connective and soft tissue
0.345 0.655 0.000
I47.9 Paroxysmal tachycardia, unspecified
0.000 0.655 0.345
E06.4 Drug-induced thyroiditis
0.000 0.656 0.344
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.656 0.344
E06.1 Subacute thyroiditis
0.000 0.656 0.344
E06.0 Acute thyroiditis
0.000 0.656 0.344
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.656 0.344
C68 Malignant neoplasm of other and unspecified urinary organs
0.344 0.656 0.000
C39 Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs
0.342 0.658 0.000
C33 Malignant neoplasm of trachea
0.342 0.658 0.000
E23.2 Diabetes insipidus
0.000 0.659 0.341
C38 Malignant neoplasm of heart, mediastinum and pleura
0.340 0.660 0.000
E06.3 Autoimmune thyroiditis
0.000 0.661 0.339
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere
0.000 0.662 0.337
I49.8 Other specified cardiac arrhythmias
0.000 0.663 0.337
I77.9 Disorder of arteries and arterioles, unspecified
0.000 0.664 0.336
C49.4 Connective and soft tissue of abdomen
0.336 0.664 0.000
E12 Malnutrition-related diabetes mellitus
0.000 0.667 0.333
I44.1 Atrioventricular block, second degree
0.000 0.667 0.332
I12 Hypertensive renal disease
0.000 0.668 0.332
E34 Other endocrine disorders
0.000 0.668 0.332
E50-E64 Other nutritional deficiencies
0.000 0.668 0.332
E27.8 Other specified disorders of adrenal gland
0.000 0.669 0.331
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.000 0.669 0.330
E21.3 Hyperparathyroidism, unspecified
0.000 0.671 0.329
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.672 0.328
E30 Disorders of puberty, not elsewhere classified
0.000 0.672 0.328
C45.2 Mesothelioma of pericardium
0.328 0.672 0.000
C45.1 Mesothelioma of peritoneum
0.328 0.672 0.000
I35.8 Other aortic valve disorders
0.000 0.673 0.327
I35.1 Aortic (valve) insufficiency
0.000 0.673 0.327
C86.6 Primary cutaneous CD30-positive T-cell proliferations
0.326 0.673 0.000
C86.4 Blastic NK-cell lymphoma
0.326 0.673 0.000
C86.3 Subcutaneous panniculitis-like T-cell lymphoma
0.326 0.673 0.000
C86.2 Enteropathy-type (intestinal) T-cell lymphoma
0.326 0.673 0.000
C86.1 Hepatosplenic T-cell lymphoma
0.326 0.673 0.000
C86.0 Extranodal NK/T-cell lymphoma, nasal type
0.326 0.673 0.000
I49.4 Other and unspecified premature depolarisation
0.000 0.674 0.325
C66 Malignant neoplasm of ureter
0.326 0.674 0.000
E10.4 With neurological complications
0.000 0.675 0.325
C88.9 Malignant immunoproliferative disease, unspecified
0.325 0.675 0.000
C88.7 Other malignant immunoproliferative diseases
0.325 0.675 0.000
C88.3 Immunoproliferative small intestinal disease
0.325 0.675 0.000
C88.2 Gamma heavy chain disease
0.325 0.675 0.000
C88.1 Alpha heavy chain disease
0.325 0.675 0.000
E21.0 Primary hyperparathyroidism
0.000 0.676 0.324
C82.4 Follicular lymphoma grade IIIb
0.323 0.677 0.000
I51.5 Myocardial degeneration
0.000 0.678 0.322
I51.2 Rupture of papillary muscle, not elsewhere classified
0.000 0.678 0.322
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.000 0.678 0.322
E07.1 Dyshormogenetic goitre
0.000 0.679 0.321
E07.0 Hypersecretion of calcitonin
0.000 0.679 0.321
E23.6 Other disorders of pituitary gland
0.000 0.679 0.321
C32.8 Overlapping lesion of larynx
0.319 0.681 0.000
C32.3 Laryngeal cartilage
0.319 0.681 0.000
C32.2 Subglottis
0.319 0.681 0.000
I70 Atherosclerosis
0.000 0.681 0.319
I77.2 Rupture of artery
0.000 0.683 0.317
I74 Arterial embolism and thrombosis
0.000 0.684 0.316
E27.9 Disorder of adrenal gland, unspecified
0.000 0.684 0.316
I77.8 Other specified disorders of arteries and arterioles
0.000 0.686 0.314
C80.0 Malignant neoplasm, primary site unknown, so stated
0.314 0.686 0.000
I44.7 Left bundle-branch block, unspecified
0.000 0.686 0.314
C30 Malignant neoplasm of nasal cavity and middle ear
0.313 0.687 0.000
C71.4 Occipital lobe
0.313 0.687 0.000
C94.7 Other specified leukaemias
0.311 0.688 0.000
C94.6 Myelodysplastic and myeloproliferative disease, not elsewhere classified
0.311 0.688 0.000
C94.5 Acute myelofibrosis
0.311 0.688 0.000
C94.4 Acute panmyelosis
0.311 0.688 0.000
C94.3 Mast cell leukaemia
0.311 0.688 0.000
C94.2 Acute megakaryoblastic leukaemia
0.311 0.688 0.000
C94.1 Chronic erythraemia
0.311 0.688 0.000
C94.0 Acute erythraemia and erythroleukaemia
0.311 0.688 0.000
C96.9 Malignant neoplasms of lymphoid, haematopoietic and related tissue, unspecified
0.311 0.688 0.000
C96.8 Histiocytic sarcoma
0.311 0.688 0.000
C96.7 Other specified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.311 0.688 0.000
C96.6 Unifocal Langerhans-cell histiocytosis
0.311 0.688 0.000
C96.5 Multifocal and unisystemic Langerhans-cell histiocytosis
0.311 0.688 0.000
C96.4 Sarcoma of dendritic cells (accessory cells)
0.311 0.688 0.000
C96.3 True histiocytic lymphoma
0.311 0.688 0.000
C96.2 Malignant mast cell tumour
0.311 0.688 0.000
C96.1 Malignant histiocytosis
0.311 0.688 0.000
C96.0 Letterer-Siwe disease
0.311 0.688 0.000
C82.6 Cutaneous follicle centre lymphoma
0.310 0.690 0.000
C82.5 Diffuse follicle centre lymphoma
0.310 0.690 0.000
I08.1 Disorders of both mitral and tricuspid valves
0.000 0.691 0.309
C76.1 Thorax
0.309 0.691 0.000
E27.2 Addisonian crisis
0.000 0.692 0.308
C45.9 Mesothelioma, unspecified
0.307 0.693 0.000
C82.3 Follicular lymphoma grade IIIa
0.306 0.693 0.000
I08.2 Disorders of both aortic and tricuspid valves
0.000 0.693 0.306
C31.0 Maxillary sinus
0.306 0.694 0.000
I01.9 Acute rheumatic heart disease, unspecified
0.000 0.695 0.305
I01.8 Other acute rheumatic heart disease
0.000 0.695 0.305
I01.2 Acute rheumatic myocarditis
0.000 0.695 0.305
I01.1 Acute rheumatic endocarditis
0.000 0.695 0.305
I01.0 Acute rheumatic pericarditis
0.000 0.695 0.305
I02.9 Rheumatic chorea without heart involvement
0.000 0.695 0.305
I02.0 Rheumatic chorea with heart involvement
0.000 0.695 0.305
I77.5 Necrosis of artery
0.000 0.695 0.305
I77.4 Coeliac artery compression syndrome
0.000 0.695 0.305
C41 Malignant neoplasm of bone and articular cartilage of other and unspecified sites
0.305 0.695 0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.696 0.304
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.696 0.304
C76.0 Head, face and neck
0.303 0.697 0.000
I06 Rheumatic aortic valve diseases
0.000 0.697 0.303
E31 Polyglandular dysfunction
0.000 0.698 0.302
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.699 0.301
E23.1 Drug-induced hypopituitarism
0.000 0.699 0.301
I98.2 Oesophageal varices in diseases classified elsewhere
0.000 0.699 0.301
E21.2 Other hyperparathyroidism
0.000 0.700 0.300
C82.1 Mixed small cleaved and large cell, follicular
0.300 0.700 0.000
C71.3 Parietal lobe
0.300 0.700 0.000
I20.0 Unstable angina
0.000 0.700 0.300
I71 Aortic aneurysm and dissection
0.000 0.700 0.300
E32 Diseases of thymus
0.000 0.702 0.298
E22 Hyperfunction of pituitary gland
0.000 0.703 0.297
C93.9 Monocytic leukaemia, unspecified
0.296 0.703 0.000
C93.7 Other monocytic leukaemia
0.296 0.703 0.000
C93.3 Juvenile myelomonocytic leukaemia
0.296 0.703 0.000
C93.2 Subacute monocytic leukaemia
0.296 0.703 0.000
C93.0 Acute monocytic leukaemia
0.296 0.703 0.000
E27.5 Adrenomedullary hyperfunction
0.000 0.704 0.295
E27.0 Other adrenocortical overactivity
0.000 0.704 0.295
E28.3 Primary ovarian failure
0.000 0.706 0.294
I47.0 Reentry ventricular arrhythmia
0.000 0.707 0.293
C32.1 Supraglottis
0.292 0.708 0.000
I51.6 Cardiovascular disease, unspecified
0.000 0.708 0.292
C71.0 Cerebrum, except lobes and ventricles
0.292 0.708 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.708 0.292
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.709 0.291
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.709 0.291
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.709 0.291
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.709 0.291
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.709 0.291
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.709 0.291
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.709 0.291
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.709 0.291
E20.9 Hypoparathyroidism, unspecified
0.000 0.711 0.289
I44.0 Atrioventricular block, first degree
0.000 0.712 0.288
E10.7 With multiple complications
0.000 0.713 0.287
E21.4 Other specified disorders of parathyroid gland
0.000 0.714 0.285
I51.4 Myocarditis, unspecified
0.000 0.715 0.285
E16 Other disorders of pancreatic internal secretion
0.000 0.716 0.284

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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