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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2239704
log Bayes Factor = 90.572
Chromosome 6   position 31,540,141  (GRCh37) Explore rs2239704 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
I20 Angina pectoris
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
I20.9 Angina pectoris, unspecified
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E10.1 With ketoacidosis
0.000 0.001 0.999
E10.4 With neurological complications
0.000 0.002 0.998
I20.0 Unstable angina
0.000 0.003 0.997
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.005 0.995
E05.9 Thyrotoxicosis, unspecified
0.000 0.005 0.995
E78.0 Pure hypercholesterolaemia
0.000 0.006 0.994
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.006 0.994
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.007 0.993
E70-E90 Metabolic disorders
0.000 0.007 0.993
E14.3 With ophthalmic complications
0.000 0.008 0.992
E14.9 Without complications
0.000 0.008 0.992
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.009 0.991
E16 Other disorders of pancreatic internal secretion
0.000 0.011 0.989
E11.3 With ophthalmic complications
0.000 0.015 0.985
E16.2 Hypoglycaemia, unspecified
0.000 0.018 0.982
M06.9 Rheumatoid arthritis, unspecified
0.000 0.033 0.967
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.039 0.961
I22 Subsequent myocardial infarction
0.000 0.040 0.960
E10.2 With renal complications
0.000 0.044 0.956
H36.0 Diabetic retinopathy
0.000 0.046 0.954
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.050 0.950
I25.5 Ischaemic cardiomyopathy
0.000 0.067 0.933
E11.1 With ketoacidosis
0.000 0.082 0.918
I24 Other acute ischaemic heart diseases
0.000 0.082 0.918
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.083 0.917
I21 Acute myocardial infarction
0.000 0.090 0.910
I21.9 Acute myocardial infarction, unspecified
0.000 0.102 0.898
E10.0 With coma
0.000 0.103 0.897
I25.2 Old myocardial infarction
0.000 0.105 0.895
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.107 0.893
E06 Thyroiditis
0.000 0.107 0.893
E13 Other specified diabetes mellitus
0.000 0.120 0.880
E10.5 With peripheral circulatory complications
0.000 0.123 0.877
E11.0 With coma
0.000 0.125 0.875
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.130 0.870
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.131 0.869
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.131 0.869
E10.8 With unspecified complications
0.000 0.134 0.866
E88 Other metabolic disorders
0.000 0.136 0.864
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.146 0.854
I24.8 Other forms of acute ischaemic heart disease
0.000 0.152 0.848
E40-E46 Malnutrition
0.000 0.152 0.848
E14.6 With other specified complications
0.000 0.158 0.842
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.164 0.836
E06.3 Autoimmune thyroiditis
0.000 0.168 0.832
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.168 0.832
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.170 0.830
E14.8 With unspecified complications
0.000 0.178 0.822
E14.4 With neurological complications
0.000 0.185 0.815
E78.1 Pure hyperglyceridaemia
0.000 0.191 0.808
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.193 0.807
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.195 0.805
E11.2 With renal complications
0.000 0.207 0.793
E10.6 With other specified complications
0.000 0.209 0.791
E78.2 Mixed hyperlipidaemia
0.000 0.218 0.782
E13.9 Without complications
0.000 0.224 0.776
E74 Other disorders of carbohydrate metabolism
0.000 0.228 0.772
M06 Other rheumatoid arthritis
0.000 0.232 0.768
E89.0 Postprocedural hypothyroidism
0.000 0.236 0.764
E78.6 Lipoprotein deficiency
0.000 0.239 0.761
E14.1 With ketoacidosis
0.000 0.244 0.756
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.247 0.753
E78.4 Other hyperlipidaemia
0.000 0.260 0.740
E46 Unspecified protein-energy malnutrition
0.000 0.261 0.739
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.262 0.738
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.265 0.735
E16.1 Other hypoglycaemia
0.000 0.269 0.731
E79 Disorders of purine and pyrimidine metabolism
0.000 0.270 0.730
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.274 0.726
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.277 0.723
E14.5 With peripheral circulatory complications
0.000 0.279 0.721
E10.7 With multiple complications
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E88.2 Lipomatosis, not elsewhere classified
0.000 0.284 0.716
I23 Certain current complications following acute myocardial infarction
0.000 0.287 0.713
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.287 0.713
E78.3 Hyperchylomicronaemia
0.000 0.288 0.712
E15 Nondiabetic hypoglycaemic coma
0.000 0.288 0.712
E77 Disorders of glycoprotein metabolism
0.000 0.288 0.712
E76 Disorders of glycosaminoglycan metabolism
0.000 0.288 0.712
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.288 0.712
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.288 0.712
I25.4 Coronary artery aneurysm
0.000 0.289 0.711
E89.3 Postprocedural hypopituitarism
0.000 0.290 0.710
E14.2 Withrenal complications
0.000 0.291 0.709
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.291 0.709
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.291 0.709
E16.4 Abnormal secretion of gastrin
0.000 0.291 0.709
E16.3 Increased secretion of glucagon
0.000 0.291 0.709
E84 Cystic fibrosis
0.000 0.294 0.705
E73 Lactose intolerance
0.000 0.299 0.701
M06.3 Rheumatoid nodule
0.000 0.303 0.697
E70 Disorders of aromatic amino-acid metabolism
0.000 0.307 0.692
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.308 0.692
E11.6 With other specified complications
0.000 0.309 0.691
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.310 0.690
E83.1 Disorders of iron metabolism
0.682 0.317 0.000
E06.5 Other chronic thyroiditis
0.000 0.324 0.676
E13.3 With ophthalmic complications
0.000 0.326 0.674
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.327 0.673
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.329 0.671
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.332 0.668
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.332 0.668
I25.6 Silent myocardial ischaemia
0.000 0.334 0.666
M06.0 Seronegative rheumatoid arthritis
0.000 0.335 0.665
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.347 0.652
E88.9 Metabolic disorder, unspecified
0.000 0.351 0.649
E72 Other disorders of amino-acid metabolism
0.000 0.357 0.643
E06.4 Drug-induced thyroiditis
0.000 0.360 0.640
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.360 0.640
E06.0 Acute thyroiditis
0.000 0.360 0.640
E89.4 Postprocedural ovarian failure
0.000 0.362 0.638
E88.3 Tumour lysis syndrome
0.000 0.366 0.634
E13.8 With unspecified complications
0.000 0.369 0.631
E13.7 With multiple complications
0.000 0.369 0.631
E13.6 With other specified complications
0.000 0.369 0.631
E13.5 With peripheral circulatory complications
0.000 0.369 0.631
E13.4 With neurological complications
0.000 0.369 0.631
E13.2 With renal complications
0.000 0.369 0.631
E13.1 With ketoacidosis
0.000 0.369 0.631
E13.0 With coma
0.000 0.369 0.631
E20-E35 Disorders of other endocrine glands
0.000 0.376 0.624
E78.8 Other disorders of lipoprotein metabolism
0.000 0.376 0.624
E88.8 Other specified metabolic disorders
0.000 0.383 0.617
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.386 0.614
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.387 0.613
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.388 0.612
E89.5 Postprocedural testicular hypofunction
0.000 0.388 0.612
E89.1 Postprocedural hypoinsulinaemia
0.000 0.388 0.612
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.389 0.611
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.392 0.608
E45 Retarded development following protein-energy malnutrition
0.000 0.392 0.608
E43 Unspecified severe protein-energy malnutrition
0.000 0.392 0.608
E42 Marasmic kwashiorkor
0.000 0.392 0.608
E41 Nutritional marasmus
0.000 0.392 0.608
E40 Kwashiorkor
0.000 0.392 0.608
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.395 0.604
E14.0 With coma
0.000 0.400 0.600
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.402 0.598
E06.1 Subacute thyroiditis
0.000 0.404 0.595
I22.8 Subsequent myocardial infarction of other sites
0.000 0.411 0.589
M06.34 Rheumatoid nodule (Hand)
0.000 0.420 0.580
I25.3 Aneurysm of heart
0.000 0.420 0.580
E03.1 Congenital hypothyroidism without goitre
0.000 0.421 0.579
I20.1 Angina pectoris with documented spasm
0.000 0.422 0.578
E06.9 Thyroiditis, unspecified
0.000 0.427 0.572
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.442 0.557
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.443 0.557
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.445 0.555
I24.1 Dressler's syndrome
0.000 0.445 0.555
E23 Hypofunction and other disorders of pituitary gland
0.000 0.446 0.554
E80.6 Other disorders of bilirubin metabolism
0.000 0.446 0.554
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.446 0.554
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.446 0.554
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.446 0.554
E74.2 Disorders of galactose metabolism
0.000 0.446 0.554
E74.1 Disorders of fructose metabolism
0.000 0.446 0.554
E74.0 Glycogen storage disease
0.000 0.446 0.554
I23.8 Other current complications following acute myocardial infarction
0.000 0.448 0.552
M06.8 Other specified rheumatoid arthritis
0.000 0.449 0.551
M06.2 Rheumatoid bursitis
0.000 0.449 0.551
M06.1 Adult-onset Still's disease
0.000 0.449 0.551
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.452 0.548
E05.8 Other thyrotoxicosis
0.000 0.457 0.542
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.458 0.541
E11.8 With unspecified complications
0.000 0.461 0.539
E03.8 Other specified hypothyroidism
0.000 0.463 0.537
E50-E64 Other nutritional deficiencies
0.000 0.465 0.535
G35 Multiple sclerosis
0.533 0.467 0.000
E23.6 Other disorders of pituitary gland
0.000 0.475 0.525
E24 Cushing's syndrome
0.000 0.476 0.524
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.476 0.523
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.476 0.523
E79.1 Lesch-Nyhan syndrome
0.000 0.476 0.523
E07 Other disorders of thyroid
0.000 0.481 0.519
H36 Retinal disorders in diseases classified elsewhere
0.000 0.482 0.518
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E11.5 With peripheral circulatory complications
0.000 0.486 0.514
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.489 0.511
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.489 0.511
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.489 0.511
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.489 0.511
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.489 0.511
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.489 0.511
E71.3 Disorders of fatty-acid metabolism
0.000 0.489 0.510
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.489 0.510
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.489 0.510
E71.0 Maple-syrup-urine disease
0.000 0.489 0.510
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.489 0.510
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.489 0.510
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.489 0.510
E76.2 Other mucopolysaccharidoses
0.000 0.489 0.510
E76.1 Mucopolysaccharidosis, type II
0.000 0.489 0.510
E76.0 Mucopolysaccharidosis, type I
0.000 0.489 0.510
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.489 0.510
E77.8 Other disorders of glycoprotein metabolism
0.000 0.489 0.510
E77.1 Defects in glycoprotein degradation
0.000 0.489 0.510
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.489 0.510
E84.8 Cystic fibrosis with other manifestations
0.000 0.494 0.506
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.494 0.506
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.494 0.506
K90 Intestinal malabsorption
0.000 0.495 0.504
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.497 0.503
E73.8 Other lactose intolerance
0.000 0.497 0.503
E73.1 Secondary lactase deficiency
0.000 0.497 0.503
E73.0 Congenital lactase deficiency
0.000 0.497 0.503
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.500 0.500
M06.38 Rheumatoid nodule (Other)
0.000 0.500 0.500
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.500 0.500
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.500 0.500
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.500 0.500
E84.9 Cystic fibrosis, unspecified
0.000 0.501 0.499
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.503 0.496
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.503 0.496
E70.2 Disorders of tyrosine metabolism
0.000 0.503 0.496
E70.1 Other hyperphenylalaninaemias
0.000 0.503 0.496
E70.0 Classical phenylketonuria
0.000 0.503 0.496
E75.6 Lipid storage disorder, unspecified
0.000 0.505 0.495
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.505 0.495
E75.3 Sphingolipidosis, unspecified
0.000 0.505 0.495
E75.2 Other sphingolipidosis
0.000 0.505 0.495
E75.1 Other gangliosidosis
0.000 0.505 0.495
E75.0 GM2 gangliosidosis
0.000 0.505 0.495
G35-G37 Demyelinating diseases of the central nervous system
0.495 0.505 0.000
E28 Ovarian dysfunction
0.000 0.507 0.493
E73.9 Lactose intolerance, unspecified
0.000 0.508 0.492
G37 Other demyelinating diseases of central nervous system
0.489 0.511 0.000
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.515 0.485
E80.1 Porphyria cutanea tarda
0.000 0.516 0.484
E80.2 Other porphyria
0.000 0.518 0.482
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.521 0.479
E80.5 Crigler-Najjar syndrome
0.000 0.521 0.479
E80.3 Defects of catalase and peroxydase
0.000 0.521 0.479
E80.0 Hereditary erythropoietic porphyria
0.000 0.521 0.479
G37.9 Demyelinating disease of central nervous system, unspecified
0.478 0.522 0.000
E61 Deficiency of other nutrient elements
0.000 0.523 0.477
E70.3 Albinism
0.000 0.523 0.477
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.523 0.477
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.523 0.477
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.523 0.477
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.523 0.477
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.523 0.477
E75.5 Other lipid storage disorders
0.000 0.527 0.473
E65-E68 Obesity and other hyperalimentation
0.000 0.536 0.464
I21.4 Acute subendocardial myocardial infarction
0.000 0.536 0.464
E22 Hyperfunction of pituitary gland
0.000 0.537 0.463
E21.3 Hyperparathyroidism, unspecified
0.000 0.538 0.462
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.539 0.461
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.539 0.461
E72.5 Disorders of glycine metabolism
0.000 0.539 0.461
E72.4 Disorders of ornithine metabolism
0.000 0.539 0.461
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.539 0.461
E72.2 Disorders of urea cycle metabolism
0.000 0.539 0.461
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.545 0.455
E23.2 Diabetes insipidus
0.000 0.548 0.452
E86 Volume depletion
0.000 0.548 0.452
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.552 0.448
E32 Diseases of thymus
0.000 0.552 0.448
E31 Polyglandular dysfunction
0.000 0.552 0.448
E30 Disorders of puberty, not elsewhere classified
0.000 0.552 0.448
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.553 0.447
E61.1 Iron deficiency
0.000 0.555 0.445
M06.33 Rheumatoid nodule (Forearm)
0.000 0.560 0.439
E44.1 Mild protein-energy malnutrition
0.000 0.564 0.436
E44.0 Moderate protein-energy malnutrition
0.000 0.564 0.436
E72.0 Disorders of amino-acid transport
0.000 0.566 0.433
E24.0 Pituitary-dependent Cushing's disease
0.000 0.567 0.433
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.569 0.431
M06.4 Inflammatory polyarthropathy
0.000 0.571 0.428
E24.2 Drug-induced Cushing's syndrome
0.000 0.572 0.428
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.575 0.424
E28.2 Polycystic ovarian syndrome
0.000 0.578 0.422
E26 Hyperaldosteronism
0.000 0.582 0.418
K90.9 Intestinal malabsorption, unspecified
0.000 0.593 0.407
G37.8 Other specified demyelinating diseases of central nervous system
0.404 0.596 0.000
E23.7 Disorder of pituitary gland, unspecified
0.000 0.596 0.404
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.596 0.403
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.601 0.399
E25 Adrenogenital disorders
0.000 0.602 0.398
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.603 0.397
E23.1 Drug-induced hypopituitarism
0.000 0.603 0.397
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.605 0.395
M06.18 Adult-onset Still's disease (Other)
0.000 0.605 0.395
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.605 0.395
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.605 0.395
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.605 0.395
M06.14 Adult-onset Still's disease (Hand)
0.000 0.605 0.395
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.605 0.395
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.605 0.395
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.605 0.395
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.605 0.395
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.605 0.395
M06.28 Rheumatoid bursitis (Other)
0.000 0.605 0.395
M06.27 Rheumatoid bursitis (Ankle and foot)
0.000 0.605 0.395
M06.26 Rheumatoid bursitis (Lower leg)
0.000 0.605 0.395
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.000 0.605 0.395
M06.24 Rheumatoid bursitis (Hand)
0.000 0.605 0.395
M06.23 Rheumatoid bursitis (Forearm)
0.000 0.605 0.395
M06.22 Rheumatoid bursitis (Upper arm)
0.000 0.605 0.395
M06.21 Rheumatoid bursitis (Shoulder region)
0.000 0.605 0.395
M06.20 Rheumatoid bursitis (Multiple sites)
0.000 0.605 0.395
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.000 0.605 0.395
M06.88 Other specified rheumatoid arthritis (Other)
0.000 0.605 0.395
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.000 0.605 0.395
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.000 0.605 0.395
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.000 0.605 0.395
M06.84 Other specified rheumatoid arthritis (Hand)
0.000 0.605 0.395
M06.83 Other specified rheumatoid arthritis (Forearm)
0.000 0.605 0.395
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.000 0.605 0.395
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.000 0.605 0.395
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.000 0.605 0.395
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.393 0.607 0.000
E21.2 Other hyperparathyroidism
0.000 0.614 0.386
E85 Amyloidosis
0.001 0.615 0.384
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.616 0.383
E63 Other nutritional deficiencies
0.000 0.616 0.383
E51 Thiamine deficiency
0.000 0.616 0.383
E50 Vitamin A deficiency
0.000 0.616 0.383
E60 Dietary zinc deficiency
0.000 0.616 0.383
E59 Dietary selenium deficiency
0.000 0.616 0.383
E52 Niacin deficiency [pellagra]
0.000 0.616 0.383
E22.0 Acromegaly and pituitary gigantism
0.000 0.617 0.383
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.619 0.381
E20 Hypoparathyroidism
0.000 0.620 0.380
E56 Other vitamin deficiencies
0.000 0.622 0.378
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.623 0.376
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.624 0.376
E24.3 Ectopic ACTH syndrome
0.000 0.624 0.376
E24.1 Nelson's syndrome
0.000 0.624 0.376
E07.1 Dyshormogenetic goitre
0.000 0.628 0.372
E07.0 Hypersecretion of calcitonin
0.000 0.628 0.372
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.628 0.371
E24.8 Other Cushing's syndrome
0.000 0.631 0.369
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.633 0.367
E07.8 Other specified disorders of thyroid
0.000 0.637 0.362
K90.3 Pancreatic steatorrhoea
0.000 0.638 0.362
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.638 0.362
K90.1 Tropical sprue
0.000 0.638 0.362
K90.8 Other intestinal malabsorption
0.000 0.643 0.357
E21.4 Other specified disorders of parathyroid gland
0.000 0.646 0.354
E28.9 Ovarian dysfunction, unspecified
0.000 0.646 0.354
E28.8 Other ovarian dysfunction
0.000 0.646 0.354
E28.1 Androgen excess
0.000 0.646 0.354
E28.0 Oestrogen excess
0.000 0.646 0.354
E83 Disorders of mineral metabolism
0.292 0.647 0.061
E24.9 Cushing's syndrome, unspecified
0.000 0.649 0.351
G37.5 Concentric sclerosis [Balo]
0.351 0.649 0.000
G37.4 Subacute necrotising myelitis
0.351 0.649 0.000
G37.2 Central pontine myelinolysis
0.351 0.649 0.000
G37.1 Central demyelination of corpus callosum
0.351 0.649 0.000
G37.0 Diffuse sclerosis
0.351 0.649 0.000
E58 Dietary calcium deficiency
0.000 0.649 0.350
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.651 0.349
E61.9 Deficiency of nutrient element, unspecified
0.000 0.658 0.342
E61.8 Deficiency of other specified nutrient elements
0.000 0.658 0.342
E61.7 Deficiency of multiple nutrient elements
0.000 0.658 0.342
E61.6 Vanadium deficiency
0.000 0.658 0.342
E61.5 Molybdenum deficiency
0.000 0.658 0.342
E61.4 Chromium deficiency
0.000 0.658 0.342
E61.3 Manganese deficiency
0.000 0.658 0.342
E61.0 Copper deficiency
0.000 0.658 0.342
G36 Other acute disseminated demyelination
0.342 0.658 0.000
E65 Localised adiposity
0.000 0.658 0.342
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.666 0.334
E67 Other hyperalimentation
0.000 0.667 0.333
E68 Sequelae of hyperalimentation
0.000 0.667 0.333
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.668 0.332
E22.8 Other hyperfunction of pituitary gland
0.000 0.668 0.332
E54 Ascorbic acid deficiency
0.000 0.672 0.328
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.674 0.326
E30.9 Disorder of puberty, unspecified
0.000 0.679 0.321
E30.8 Other disorders of puberty
0.000 0.679 0.321
E30.1 Precocious puberty
0.000 0.679 0.321
E30.0 Delayed puberty
0.000 0.679 0.321
E31.9 Polyglandular dysfunction, unspecified
0.000 0.679 0.321
E31.8 Other polyglandular dysfunction
0.000 0.679 0.321
E31.1 Polyglandular hyperfunction
0.000 0.679 0.321
E31.0 Autoimmune polyglandular failure
0.000 0.679 0.321
E32.9 Disease of thymus, unspecified
0.000 0.679 0.321
E32.8 Other diseases of thymus
0.000 0.679 0.321
E32.1 Abscess of thymus
0.000 0.679 0.321
E32.0 Persistent hyperplasia of thymus
0.000 0.679 0.321
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.679 0.321
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.679 0.321
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.679 0.321
E29 Testicular dysfunction
0.000 0.680 0.319
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.689 0.311
E28.3 Primary ovarian failure
0.000 0.692 0.308
E61.2 Magnesium deficiency
0.000 0.692 0.308
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.693 0.307
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.693 0.307
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.693 0.307
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.693 0.307
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.693 0.307
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.693 0.307
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.693 0.307
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.693 0.307
E89.2 Postprocedural hypoparathyroidism
0.001 0.695 0.305
E26.9 Hyperaldosteronism, unspecified
0.000 0.700 0.299
E26.8 Other hyperaldosteronism
0.000 0.700 0.299
E26.1 Secondary hyperaldosteronism
0.000 0.700 0.299
E25.9 Adrenogenital disorder, unspecified
0.000 0.714 0.285
E25.8 Other adrenogenital disorders
0.000 0.714 0.285
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.724 0.276
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.724 0.276
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.724 0.276
E50.9 Vitamin A deficiency, unspecified
0.000 0.725 0.275
E50.8 Other manifestations of vitamin A deficiency
0.000 0.725 0.275
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.725 0.275
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.725 0.275
E50.5 Vitamin A deficiency with night blindness
0.000 0.725 0.275
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.725 0.275
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.725 0.275
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.725 0.275
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.725 0.275
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.725 0.275
E51.9 Thiamine deficiency, unspecified
0.000 0.725 0.275
E51.8 Other manifestations of thiamine deficiency
0.000 0.725 0.275
E51.2 Wernicke's encephalopathy
0.000 0.725 0.275
E51.1 Beriberi
0.000 0.725 0.275
E63.9 Nutritional deficiency, unspecified
0.000 0.725 0.275
E63.8 Other specified nutritional deficiencies
0.000 0.725 0.275
E63.1 Imbalance of constituents of food intake
0.000 0.725 0.275
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.725 0.275
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.725 0.275
E64.8 Sequelae of other nutritional deficiencies
0.000 0.725 0.275
E64.3 Sequelae of rickets
0.000 0.725 0.275
E64.2 Sequelae of vitamin C deficiency
0.000 0.725 0.275
E64.1 Sequelae of vitamin A deficiency
0.000 0.725 0.275
E64.0 Sequelae of protein-energy malnutrition
0.000 0.725 0.275
E20.1 Pseudohypoparathyroidism
0.000 0.727 0.272
E20.0 Idiopathic hypoparathyroidism
0.000 0.727 0.272
E27 Other disorders of adrenal gland
0.000 0.728 0.272
E56.9 Vitamin deficiency, unspecified
0.000 0.729 0.271
E56.8 Deficiency of other vitamins
0.000 0.729 0.271
E56.0 Deficiency of vitamin E
0.000 0.729 0.271
E34 Other endocrine disorders
0.001 0.730 0.269
E26.0 Primary hyperaldosteronism
0.000 0.731 0.269
E55 Vitamin D deficiency
0.000 0.732 0.268
E83.9 Disorder of mineral metabolism, unspecified
0.231 0.732 0.038
E56.1 Deficiency of vitamin K
0.000 0.734 0.266
E80.4 Gilbert's syndrome
0.000 0.734 0.266
E83.8 Other disorders of mineral metabolism
0.209 0.747 0.044
E83.2 Disorders of zinc metabolism
0.209 0.747 0.044
E83.0 Disorders of copper metabolism
0.209 0.747 0.044
E85.4 Organ-limited amyloidosis
0.000 0.750 0.250
E53 Deficiency of other B group vitamins
0.000 0.754 0.246
E83.3 Disorders of phosphorus metabolism
0.226 0.754 0.020
G36.9 Acute disseminated demyelination, unspecified
0.245 0.755 0.000
G36.8 Other specified acute disseminated demyelination
0.245 0.755 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.245 0.755 0.000
E20.9 Hypoparathyroidism, unspecified
0.000 0.757 0.243
E20.8 Other hypoparathyroidism
0.000 0.757 0.242

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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