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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2246871
log Bayes Factor = 70.688
Chromosome 6   position 31,481,146  (GRCh37) Explore rs2246871 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.001 0.999
I20 Angina pectoris
0.000 0.002 0.998
E05.9 Thyrotoxicosis, unspecified
0.000 0.002 0.998
I25 Chronic ischaemic heart disease
0.000 0.002 0.998
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.002 0.998
I25.1 Atherosclerotic heart disease
0.000 0.002 0.998
E10.1 With ketoacidosis
0.000 0.003 0.997
I22 Subsequent myocardial infarction
0.000 0.003 0.997
I20.9 Angina pectoris, unspecified
0.000 0.003 0.997
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.003 0.997
E14.9 Without complications
0.000 0.007 0.993
E14.3 With ophthalmic complications
0.000 0.009 0.991
M06.9 Rheumatoid arthritis, unspecified
0.000 0.009 0.991
E10.4 With neurological complications
0.000 0.012 0.988
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.013 0.987
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.019 0.981
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.022 0.978
M45 Ankylosing spondylitis
0.000 0.024 0.976
I25.5 Ischaemic cardiomyopathy
0.000 0.028 0.972
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.051 0.949
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.051 0.949
I20.0 Unstable angina
0.000 0.062 0.938
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.074 0.926
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.078 0.922
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.078 0.922
I24 Other acute ischaemic heart diseases
0.000 0.082 0.918
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.097 0.903
I21 Acute myocardial infarction
0.000 0.099 0.901
E06 Thyroiditis
0.000 0.100 0.900
E10.2 With renal complications
0.000 0.102 0.898
G35 Multiple sclerosis
0.892 0.108 0.000
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.124 0.876
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.125 0.875
E10.0 With coma
0.000 0.143 0.857
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.144 0.856
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.147 0.853
I21.9 Acute myocardial infarction, unspecified
0.000 0.157 0.843
E10.5 With peripheral circulatory complications
0.000 0.164 0.835
E16 Other disorders of pancreatic internal secretion
0.000 0.165 0.835
E06.3 Autoimmune thyroiditis
0.000 0.169 0.831
G35-G37 Demyelinating diseases of the central nervous system
0.817 0.183 0.000
I23 Certain current complications following acute myocardial infarction
0.000 0.187 0.813
E14.8 With unspecified complications
0.000 0.193 0.806
G37 Other demyelinating diseases of central nervous system
0.804 0.196 0.000
E14.6 With other specified complications
0.000 0.197 0.803
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.204 0.796
G37.9 Demyelinating disease of central nervous system, unspecified
0.793 0.207 0.000
E10.8 With unspecified complications
0.000 0.212 0.788
L40.9 Psoriasis, unspecified
0.783 0.217 0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.221 0.779
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.233 0.767
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.234 0.766
I20.1 Angina pectoris with documented spasm
0.000 0.236 0.764
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.240 0.760
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.245 0.755
E14.4 With neurological complications
0.000 0.253 0.747
I22.8 Subsequent myocardial infarction of other sites
0.000 0.256 0.744
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.281 0.719
E10.7 With multiple complications
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.284 0.715
E14.1 With ketoacidosis
0.000 0.288 0.712
I24.8 Other forms of acute ischaemic heart disease
0.000 0.289 0.711
E14.5 With peripheral circulatory complications
0.000 0.300 0.700
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.300 0.700
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.300 0.700
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.300 0.700
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.300 0.700
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.300 0.700
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.300 0.700
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.300 0.700
E16.2 Hypoglycaemia, unspecified
0.000 0.302 0.698
I23.8 Other current complications following acute myocardial infarction
0.000 0.320 0.680
E14.2 Withrenal complications
0.000 0.336 0.664
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.340 0.660
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.340 0.659
E15 Nondiabetic hypoglycaemic coma
0.000 0.353 0.647
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.354 0.646
E06.5 Other chronic thyroiditis
0.000 0.354 0.645
E06.4 Drug-induced thyroiditis
0.000 0.354 0.645
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.354 0.645
E06.1 Subacute thyroiditis
0.000 0.354 0.645
E06.0 Acute thyroiditis
0.000 0.354 0.645
E13 Other specified diabetes mellitus
0.000 0.361 0.638
G37.8 Other specified demyelinating diseases of central nervous system
0.638 0.362 0.000
E06.9 Thyroiditis, unspecified
0.000 0.363 0.637
I25.3 Aneurysm of heart
0.000 0.375 0.625
E10.6 With other specified complications
0.000 0.380 0.620
M06 Other rheumatoid arthritis
0.000 0.381 0.619
E83.1 Disorders of iron metabolism
0.618 0.382 0.000
I25.4 Coronary artery aneurysm
0.000 0.382 0.618
E14.0 With coma
0.000 0.387 0.612
I24.1 Dressler's syndrome
0.000 0.390 0.610
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.400 0.600
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.401 0.599
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.401 0.599
E16.4 Abnormal secretion of gastrin
0.000 0.401 0.599
E16.3 Increased secretion of glucagon
0.000 0.401 0.599
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.406 0.594
E40-E46 Malnutrition
0.000 0.408 0.592
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.417 0.583
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.417 0.583
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.417 0.583
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.417 0.583
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.417 0.583
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.417 0.583
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.417 0.583
E07 Other disorders of thyroid
0.000 0.419 0.581
G37.5 Concentric sclerosis [Balo]
0.577 0.423 0.000
G37.4 Subacute necrotising myelitis
0.577 0.423 0.000
G37.2 Central pontine myelinolysis
0.577 0.423 0.000
G37.1 Central demyelination of corpus callosum
0.577 0.423 0.000
G37.0 Diffuse sclerosis
0.577 0.423 0.000
E65-E68 Obesity and other hyperalimentation
0.000 0.429 0.571
E03.1 Congenital hypothyroidism without goitre
0.000 0.430 0.569
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.565 0.435 0.000
G36 Other acute disseminated demyelination
0.554 0.446 0.000
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.451 0.549
E16.1 Other hypoglycaemia
0.000 0.458 0.542
E11 Non-insulin-dependent diabetes mellitus
0.000 0.460 0.540
H36.0 Diabetic retinopathy
0.000 0.473 0.527
M06.0 Seronegative rheumatoid arthritis
0.000 0.476 0.524
E05.8 Other thyrotoxicosis
0.000 0.479 0.520
E03.8 Other specified hypothyroidism
0.000 0.482 0.518
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E78.0 Pure hypercholesterolaemia
0.000 0.495 0.505
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.498 0.502
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.499 0.501
E70-E90 Metabolic disorders
0.000 0.500 0.500
M06.3 Rheumatoid nodule
0.000 0.505 0.495
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.506 0.494
E11.0 With coma
0.000 0.507 0.493
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.510 0.489
E65 Localised adiposity
0.000 0.529 0.471
E13.8 With unspecified complications
0.000 0.542 0.458
E13.7 With multiple complications
0.000 0.542 0.458
E13.6 With other specified complications
0.000 0.542 0.458
E13.5 With peripheral circulatory complications
0.000 0.542 0.458
E13.4 With neurological complications
0.000 0.542 0.458
E13.3 With ophthalmic complications
0.000 0.542 0.458
E13.2 With renal complications
0.000 0.542 0.458
E13.1 With ketoacidosis
0.000 0.542 0.458
E13.0 With coma
0.000 0.542 0.458
E50-E64 Other nutritional deficiencies
0.000 0.553 0.447
M06.8 Other specified rheumatoid arthritis
0.000 0.556 0.443
M06.2 Rheumatoid bursitis
0.000 0.556 0.443
M06.1 Adult-onset Still's disease
0.000 0.556 0.443
M06.34 Rheumatoid nodule (Hand)
0.000 0.562 0.438
E11.9 Without complications
0.000 0.569 0.431
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.575 0.424
E45 Retarded development following protein-energy malnutrition
0.000 0.575 0.424
E43 Unspecified severe protein-energy malnutrition
0.000 0.575 0.424
E42 Marasmic kwashiorkor
0.000 0.575 0.424
E41 Nutritional marasmus
0.000 0.575 0.424
E40 Kwashiorkor
0.000 0.575 0.424
E11.3 With ophthalmic complications
0.000 0.576 0.424
E78.1 Pure hyperglyceridaemia
0.000 0.578 0.422
E07.1 Dyshormogenetic goitre
0.000 0.583 0.417
E07.0 Hypersecretion of calcitonin
0.000 0.583 0.417
E11.1 With ketoacidosis
0.000 0.589 0.411
E67 Other hyperalimentation
0.000 0.590 0.410
E68 Sequelae of hyperalimentation
0.000 0.590 0.410
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.600 0.400
G36.9 Acute disseminated demyelination, unspecified
0.397 0.603 0.000
G36.8 Other specified acute disseminated demyelination
0.397 0.603 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.397 0.603 0.000
E73 Lactose intolerance
0.000 0.603 0.397
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.607 0.393
E11.7 With multiple complications
0.000 0.613 0.387
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.614 0.386
E11.2 With renal complications
0.000 0.615 0.385
E13.9 Without complications
0.000 0.621 0.379
E07.8 Other specified disorders of thyroid
0.000 0.621 0.379
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.624 0.375
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.624 0.375
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.624 0.375
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.624 0.375
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.624 0.375
E70 Disorders of aromatic amino-acid metabolism
0.000 0.630 0.370
K90 Intestinal malabsorption
0.000 0.632 0.368
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.634 0.366
G36.0 Neuromyelitis optica [Devic]
0.365 0.635 0.000
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.636 0.364
E51 Thiamine deficiency
0.000 0.640 0.360
E77 Disorders of glycoprotein metabolism
0.000 0.641 0.358
E76 Disorders of glycosaminoglycan metabolism
0.000 0.641 0.358
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.641 0.358
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.641 0.358
E89.3 Postprocedural hypopituitarism
0.000 0.644 0.356
E72 Other disorders of amino-acid metabolism
0.000 0.644 0.355
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.645 0.355
M06.38 Rheumatoid nodule (Other)
0.000 0.645 0.355
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.645 0.355
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.645 0.355
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.645 0.355
E78.3 Hyperchylomicronaemia
0.000 0.646 0.354
E78.2 Mixed hyperlipidaemia
0.000 0.647 0.352
E84 Cystic fibrosis
0.000 0.649 0.351
E79 Disorders of purine and pyrimidine metabolism
0.000 0.650 0.349
M06.4 Inflammatory polyarthropathy
0.000 0.651 0.348
M35.0 Sicca syndrome [Sjogren]
0.000 0.652 0.348
E78.6 Lipoprotein deficiency
0.000 0.654 0.346
E11.8 With unspecified complications
0.000 0.656 0.344
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.660 0.340
E61 Deficiency of other nutrient elements
0.000 0.660 0.339
E07.9 Disorder of thyroid, unspecified
0.000 0.663 0.337
E74 Other disorders of carbohydrate metabolism
0.000 0.664 0.336
M35 Other systemic involvement of connective tissue
0.000 0.673 0.327
E80.6 Other disorders of bilirubin metabolism
0.000 0.676 0.324
E73.9 Lactose intolerance, unspecified
0.000 0.677 0.323
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.680 0.320
E63 Other nutritional deficiencies
0.000 0.680 0.320
E50 Vitamin A deficiency
0.000 0.680 0.320
E60 Dietary zinc deficiency
0.000 0.680 0.320
E59 Dietary selenium deficiency
0.000 0.680 0.320
E52 Niacin deficiency [pellagra]
0.000 0.680 0.320
E78.8 Other disorders of lipoprotein metabolism
0.000 0.681 0.319
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.682 0.318
M06.18 Adult-onset Still's disease (Other)
0.000 0.682 0.318
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.682 0.318
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.682 0.318
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.682 0.318
M06.14 Adult-onset Still's disease (Hand)
0.000 0.682 0.318
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.682 0.318
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.682 0.318
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.682 0.318
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.682 0.318
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.682 0.318
M06.28 Rheumatoid bursitis (Other)
0.000 0.682 0.318
M06.27 Rheumatoid bursitis (Ankle and foot)
0.000 0.682 0.318
M06.26 Rheumatoid bursitis (Lower leg)
0.000 0.682 0.318
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.000 0.682 0.318
M06.24 Rheumatoid bursitis (Hand)
0.000 0.682 0.318
M06.23 Rheumatoid bursitis (Forearm)
0.000 0.682 0.318
M06.22 Rheumatoid bursitis (Upper arm)
0.000 0.682 0.318
M06.21 Rheumatoid bursitis (Shoulder region)
0.000 0.682 0.318
M06.20 Rheumatoid bursitis (Multiple sites)
0.000 0.682 0.318
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.000 0.682 0.318
M06.88 Other specified rheumatoid arthritis (Other)
0.000 0.682 0.318
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.000 0.682 0.318
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.000 0.682 0.318
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.000 0.682 0.318
M06.84 Other specified rheumatoid arthritis (Hand)
0.000 0.682 0.318
M06.83 Other specified rheumatoid arthritis (Forearm)
0.000 0.682 0.318
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.000 0.682 0.318
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.000 0.682 0.318
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.000 0.682 0.318
E11.6 With other specified complications
0.000 0.682 0.318
I25.2 Old myocardial infarction
0.000 0.683 0.317
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.684 0.316
E58 Dietary calcium deficiency
0.000 0.685 0.315
E56 Other vitamin deficiencies
0.000 0.686 0.314
E89.0 Postprocedural hypothyroidism
0.000 0.686 0.314
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.687 0.313
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.688 0.312
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.689 0.311
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.693 0.307
E44.1 Mild protein-energy malnutrition
0.000 0.695 0.304
E44.0 Moderate protein-energy malnutrition
0.000 0.695 0.304
M06.33 Rheumatoid nodule (Forearm)
0.000 0.697 0.303
E46 Unspecified protein-energy malnutrition
0.000 0.699 0.301
E80.2 Other porphyria
0.000 0.701 0.299
E51.2 Wernicke's encephalopathy
0.000 0.702 0.298
M35.1 Other overlap syndromes
0.000 0.702 0.298
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.704 0.296
E67.8 Other specified hyperalimentation
0.000 0.706 0.294
E67.3 Hypervitaminosis D
0.000 0.706 0.294
E67.2 Megavitamin-B6 syndrome
0.000 0.706 0.294
E67.1 Hypercarotenaemia
0.000 0.706 0.294
E67.0 Hypervitaminosis A
0.000 0.706 0.294
E54 Ascorbic acid deficiency
0.000 0.710 0.290
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.713 0.287
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.713 0.287
E89.5 Postprocedural testicular hypofunction
0.000 0.713 0.287
E89.1 Postprocedural hypoinsulinaemia
0.000 0.713 0.287
E73.8 Other lactose intolerance
0.000 0.715 0.285
E73.1 Secondary lactase deficiency
0.000 0.715 0.285
E73.0 Congenital lactase deficiency
0.000 0.715 0.285
M35.2 Behcet's disease
0.000 0.717 0.283
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.718 0.282
E80.5 Crigler-Najjar syndrome
0.000 0.718 0.282
E80.3 Defects of catalase and peroxydase
0.000 0.718 0.282
E80.0 Hereditary erythropoietic porphyria
0.000 0.718 0.282
E85 Amyloidosis
0.000 0.718 0.281
E61.1 Iron deficiency
0.000 0.721 0.279
E70.3 Albinism
0.000 0.723 0.277
E89.4 Postprocedural ovarian failure
0.000 0.724 0.276
E80.4 Gilbert's syndrome
0.000 0.727 0.273
H36 Retinal disorders in diseases classified elsewhere
0.000 0.728 0.272
E78.4 Other hyperlipidaemia
0.000 0.730 0.270
K90.9 Intestinal malabsorption, unspecified
0.000 0.731 0.269
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.735 0.265
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.735 0.265
E70.2 Disorders of tyrosine metabolism
0.000 0.735 0.265
E70.1 Other hyperphenylalaninaemias
0.000 0.735 0.265
E70.0 Classical phenylketonuria
0.000 0.735 0.265
K90.3 Pancreatic steatorrhoea
0.000 0.736 0.264
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.736 0.264
K90.1 Tropical sprue
0.000 0.736 0.264
L40 Psoriasis
0.264 0.736 0.000
E80.1 Porphyria cutanea tarda
0.000 0.740 0.260
E51.9 Thiamine deficiency, unspecified
0.000 0.742 0.258
E51.8 Other manifestations of thiamine deficiency
0.000 0.742 0.258
E51.1 Beriberi
0.000 0.742 0.258
E71.3 Disorders of fatty-acid metabolism
0.000 0.743 0.257
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.743 0.257
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.743 0.257
E71.0 Maple-syrup-urine disease
0.000 0.743 0.257
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.743 0.257
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.743 0.257
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.743 0.257
E76.2 Other mucopolysaccharidoses
0.000 0.743 0.257
E76.1 Mucopolysaccharidosis, type II
0.000 0.743 0.257
E76.0 Mucopolysaccharidosis, type I
0.000 0.743 0.257
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.743 0.257
E77.8 Other disorders of glycoprotein metabolism
0.000 0.743 0.257
E77.1 Defects in glycoprotein degradation
0.000 0.743 0.257
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.743 0.257
K90.8 Other intestinal malabsorption
0.000 0.744 0.256
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.745 0.255
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.745 0.255
E72.5 Disorders of glycine metabolism
0.000 0.745 0.255
E72.4 Disorders of ornithine metabolism
0.000 0.745 0.255
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.745 0.255
E72.2 Disorders of urea cycle metabolism
0.000 0.745 0.255
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.745 0.255
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.001 0.745 0.255
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.745 0.254
E72.0 Disorders of amino-acid transport
0.000 0.748 0.252
E84.8 Cystic fibrosis with other manifestations
0.000 0.748 0.252
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.748 0.252
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.748 0.252
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.749 0.251
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.749 0.251
E79.1 Lesch-Nyhan syndrome
0.000 0.749 0.251
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.750 0.250
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.750 0.250
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.750 0.250
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.750 0.250
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.750 0.250
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.750 0.250
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.750 0.250
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.750 0.250
M35.8 Other specified systemic involvement of connective tissue
0.000 0.750 0.250
E84.9 Cystic fibrosis, unspecified
0.000 0.756 0.244
M35.7 Hypermobility syndrome
0.000 0.756 0.244
E61.9 Deficiency of nutrient element, unspecified
0.000 0.756 0.243
E61.8 Deficiency of other specified nutrient elements
0.000 0.756 0.243
E61.7 Deficiency of multiple nutrient elements
0.000 0.756 0.243
E61.6 Vanadium deficiency
0.000 0.756 0.243
E61.5 Molybdenum deficiency
0.000 0.756 0.243
E61.4 Chromium deficiency
0.000 0.756 0.243
E61.3 Manganese deficiency
0.000 0.756 0.243
E61.0 Copper deficiency
0.000 0.756 0.243
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.758 0.242
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.759 0.241
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.759 0.241
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.759 0.241
E74.2 Disorders of galactose metabolism
0.000 0.759 0.241
E74.1 Disorders of fructose metabolism
0.000 0.759 0.241
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.759 0.241
M34 Systemic sclerosis
0.000 0.766 0.234
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.766 0.234
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.766 0.234
M35.5 Multifocal fibrosclerosis
0.000 0.766 0.234
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.766 0.234
L40.0 Psoriasis vulgaris
0.232 0.768 0.000
M34.1 CR(E)ST syndrome
0.000 0.768 0.232
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.770 0.230
E50.9 Vitamin A deficiency, unspecified
0.000 0.770 0.230
E50.8 Other manifestations of vitamin A deficiency
0.000 0.770 0.230
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.770 0.230
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.770 0.230
E50.5 Vitamin A deficiency with night blindness
0.000 0.770 0.230
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.770 0.230
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.770 0.230
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.770 0.230
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.770 0.230
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.770 0.230
E63.9 Nutritional deficiency, unspecified
0.000 0.770 0.230
E63.8 Other specified nutritional deficiencies
0.000 0.770 0.230
E63.1 Imbalance of constituents of food intake
0.000 0.770 0.230
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.770 0.230
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.770 0.230
E64.8 Sequelae of other nutritional deficiencies
0.000 0.770 0.230
E64.3 Sequelae of rickets
0.000 0.770 0.230
E64.2 Sequelae of vitamin C deficiency
0.000 0.770 0.230
E64.1 Sequelae of vitamin A deficiency
0.000 0.770 0.230
E64.0 Sequelae of protein-energy malnutrition
0.000 0.770 0.230
E55 Vitamin D deficiency
0.000 0.771 0.229
E75.6 Lipid storage disorder, unspecified
0.000 0.773 0.227
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.773 0.227
E75.3 Sphingolipidosis, unspecified
0.000 0.773 0.227
E75.2 Other sphingolipidosis
0.000 0.773 0.227
E75.1 Other gangliosidosis
0.000 0.773 0.227
E75.0 GM2 gangliosidosis
0.000 0.773 0.227
E56.9 Vitamin deficiency, unspecified
0.000 0.774 0.225
E56.8 Deficiency of other vitamins
0.000 0.774 0.225
E56.0 Deficiency of vitamin E
0.000 0.774 0.225
M34.9 Systemic sclerosis, unspecified
0.000 0.775 0.224
E56.1 Deficiency of vitamin K
0.000 0.780 0.219
E74.0 Glycogen storage disease
0.000 0.780 0.219
E61.2 Magnesium deficiency
0.000 0.782 0.217
E85.9 Amyloidosis, unspecified
0.000 0.783 0.217
M23.33 Other meniscus derangements (Medial collateral ligament or Other and unspecified medial meniscus)
0.000 0.785 0.215
M20-M25 Other joint disorders
0.000 0.787 0.213
M35.3 Polymyalgia rheumatica
0.000 0.788 0.212
M34.8 Other forms of systemic sclerosis
0.000 0.794 0.206
I21.4 Acute subendocardial myocardial infarction
0.000 0.794 0.206
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.798 0.202
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.798 0.202
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.798 0.202
M23.3 Other meniscus derangements
0.000 0.798 0.202
M45-M49 Spondylopathies
0.000 0.802 0.198
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.804 0.195
E85.4 Organ-limited amyloidosis
0.000 0.807 0.193
E88 Other metabolic disorders
0.000 0.808 0.192
K60.2 Anal fissure, unspecified
0.000 0.809 0.191
E83 Disorders of mineral metabolism
0.082 0.810 0.108
L40.4 Guttate psoriasis
0.189 0.810 0.000
L40.2 Acrodermatitis continua
0.189 0.810 0.000
L40.3 Pustulosis palmaris et plantaris
0.187 0.813 0.000
E75.5 Other lipid storage disorders
0.001 0.815 0.184
M23 Internal derangement of knee
0.000 0.816 0.184
L40.1 Generalised pustular psoriasis
0.179 0.821 0.000
M23.34 Other meniscus derangements (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.000 0.826 0.174
M23.35 Other meniscus derangements (Posterior horn of lateral meniscus)
0.000 0.829 0.171
M34.2 Systemic sclerosis induced by drugs and chemicals
0.000 0.832 0.168
M34.0 Progressive systemic sclerosis
0.000 0.832 0.168
M35.99 Systemic involvement of connective tissue, unspecified, Site unspecified
0.000 0.832 0.168
L40.8 Other psoriasis
0.168 0.832 0.000
M05-M14 Inflammatory polyarthropathies
0.000 0.833 0.167
E85.3 Secondary systemic amyloidosis
0.000 0.834 0.165
E55.0 Rickets, active
0.000 0.836 0.164
E11.5 With peripheral circulatory complications
0.000 0.837 0.163
E85.8 Other amyloidosis
0.001 0.837 0.162
M32 Systemic lupus erythematosus
0.000 0.838 0.162
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.841 0.159
E20-E35 Disorders of other endocrine glands
0.000 0.842 0.158
M23.36 Other meniscus derangements (Other and unspecified lateral meniscus)
0.000 0.843 0.157
E53 Deficiency of other B group vitamins
0.000 0.844 0.156
M23.39 Other meniscus derangements (Unspecified ligament or Unspecified meniscus)
0.000 0.844 0.156
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.000 0.848 0.151
M22 Disorders of patella
0.000 0.850 0.150
M49 Spondylopathies in diseases classified elsewhere
0.000 0.852 0.148
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.001 0.854 0.145
M23.37 Other meniscus derangements-Capsular lig
0.000 0.855 0.145
E88.3 Tumour lysis syndrome
0.000 0.857 0.143
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.858 0.142
M23.32 Other meniscus derangements (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.000 0.859 0.141
E88.2 Lipomatosis, not elsewhere classified
0.000 0.859 0.140
E88.9 Metabolic disorder, unspecified
0.000 0.863 0.137
E83.9 Disorder of mineral metabolism, unspecified
0.059 0.864 0.078
E83.8 Other disorders of mineral metabolism
0.059 0.864 0.078
E83.2 Disorders of zinc metabolism
0.059 0.864 0.078
E83.0 Disorders of copper metabolism
0.059 0.864 0.078
E86 Volume depletion
0.000 0.867 0.133
M23.0 Cystic meniscus
0.000 0.869 0.131
M30 Polyarteritis nodosa and related conditions
0.000 0.870 0.130
E88.8 Other specified metabolic disorders
0.000 0.870 0.129
E22 Hyperfunction of pituitary gland
0.000 0.873 0.127

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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