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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2251468
log Bayes Factor = 12.8224
Chromosome 12   position 121,405,126  (GRCh37) Explore rs2251468 on Ensembl!
Variant rs2251468 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
I25.1 Atherosclerotic heart disease
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
E78.0 Pure hypercholesterolaemia
0.000 0.001 0.999
I25 Chronic ischaemic heart disease
0.000 0.001 0.999
K80.2 Calculus of gallbladder without cholecystitis
0.997 0.003 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.006 0.994
E10-E14 Diabetes mellitus
0.000 0.006 0.994
I20-I25 Ischaemic heart diseases
0.000 0.008 0.992
K80 Cholelithiasis
0.991 0.009 0.000
K80.1 Calculus of gallbladder with other cholecystitis
0.990 0.010 0.000
E10 Insulin-dependent diabetes mellitus
0.000 0.017 0.983
I20 Angina pectoris
0.000 0.023 0.977
I20.0 Unstable angina
0.000 0.025 0.975
E11.3 With ophthalmic complications
0.000 0.029 0.971
I21 Acute myocardial infarction
0.000 0.043 0.957
E70-E90 Metabolic disorders
0.000 0.057 0.943
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.062 0.938
E10.3 With ophthalmic complications
0.000 0.063 0.937
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.071 0.929
I25.2 Old myocardial infarction
0.000 0.077 0.923
E11.4 With neurological complications
0.000 0.081 0.919
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.089 0.911
I22 Subsequent myocardial infarction
0.000 0.092 0.908
E10.4 With neurological complications
0.000 0.093 0.907
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.094 0.906
E78.4 Other hyperlipidaemia
0.000 0.103 0.897
E10.2 With renal complications
0.000 0.123 0.877
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.125 0.875
E87 Other disorders of fluid, electrolyte and acid-base balance
0.000 0.143 0.857
K80.8 Other cholelithiasis
0.855 0.145 0.000
I25.4 Coronary artery aneurysm
0.000 0.147 0.853
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.148 0.852
I21.9 Acute myocardial infarction, unspecified
0.000 0.152 0.848
E87.6 Hypokalaemia
0.000 0.152 0.848
E78.1 Pure hyperglyceridaemia
0.000 0.154 0.846
E10.5 With peripheral circulatory complications
0.000 0.159 0.841
E10.8 With unspecified complications
0.000 0.182 0.818
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.185 0.815
E88 Other metabolic disorders
0.000 0.188 0.812
K80.4 Calculus of bile duct with cholecystitis
0.811 0.189 0.000
E11.6 With other specified complications
0.000 0.211 0.789
E84 Cystic fibrosis
0.000 0.236 0.764
E78.2 Mixed hyperlipidaemia
0.000 0.237 0.763
E11.2 With renal complications
0.000 0.261 0.739
E10.7 With multiple complications
0.000 0.262 0.738
I22.8 Subsequent myocardial infarction of other sites
0.000 0.266 0.734
E11.0 With coma
0.000 0.269 0.731
E10.6 With other specified complications
0.000 0.271 0.729
E78.3 Hyperchylomicronaemia
0.000 0.271 0.728
E10.0 With coma
0.000 0.275 0.724
E85 Amyloidosis
0.000 0.278 0.722
E11.7 With multiple complications
0.000 0.283 0.717
E87.2 Acidosis
0.000 0.285 0.715
E12 Malnutrition-related diabetes mellitus
0.000 0.287 0.713
K80.3 Calculus of bile duct with cholangitis
0.710 0.290 0.000
E13 Other specified diabetes mellitus
0.000 0.290 0.710
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.299 0.701
E70 Disorders of aromatic amino-acid metabolism
0.000 0.301 0.699
I25.5 Ischaemic cardiomyopathy
0.000 0.303 0.697
E11.8 With unspecified complications
0.000 0.306 0.693
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.311 0.689
E74 Other disorders of carbohydrate metabolism
0.000 0.312 0.688
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.314 0.686
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.315 0.685
I25.6 Silent myocardial ischaemia
0.000 0.317 0.683
E76 Disorders of glycosaminoglycan metabolism
0.000 0.324 0.676
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.324 0.676
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.324 0.676
E73 Lactose intolerance
0.000 0.327 0.672
I20.8 Other forms of angina pectoris
0.000 0.335 0.665
E11.1 With ketoacidosis
0.000 0.336 0.664
E11.5 With peripheral circulatory complications
0.000 0.336 0.664
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.341 0.659
E88.3 Tumour lysis syndrome
0.000 0.341 0.659
E72 Other disorders of amino-acid metabolism
0.000 0.341 0.658
E78.5 Hyperlipidaemia, unspecified
0.000 0.351 0.649
E79 Disorders of purine and pyrimidine metabolism
0.000 0.353 0.647
E78.6 Lipoprotein deficiency
0.000 0.357 0.643
E87.3 Alkalosis
0.000 0.365 0.635
E77 Disorders of glycoprotein metabolism
0.000 0.368 0.632
E88.9 Metabolic disorder, unspecified
0.000 0.371 0.629
E87.5 Hyperkalaemia
0.000 0.377 0.623
E84.9 Cystic fibrosis, unspecified
0.000 0.379 0.620
E88.8 Other specified metabolic disorders
0.000 0.384 0.616
E87.4 Mixed disorder of acid-base balance
0.000 0.385 0.615
E78.8 Other disorders of lipoprotein metabolism
0.000 0.412 0.588
I23 Certain current complications following acute myocardial infarction
0.000 0.418 0.581
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.421 0.579
E50-E64 Other nutritional deficiencies
0.000 0.422 0.578
E85.9 Amyloidosis, unspecified
0.000 0.429 0.571
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.430 0.570
E85.3 Secondary systemic amyloidosis
0.000 0.431 0.569
I25.3 Aneurysm of heart
0.000 0.432 0.568
E87.0 Hyperosmolality and hypernatraemia
0.000 0.435 0.565
I24 Other acute ischaemic heart diseases
0.000 0.440 0.560
E84.8 Cystic fibrosis with other manifestations
0.000 0.452 0.547
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.452 0.547
E13.9 Without complications
0.000 0.466 0.534
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.467 0.533
E16 Other disorders of pancreatic internal secretion
0.000 0.469 0.531
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.471 0.529
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.474 0.525
E70.3 Albinism
0.000 0.475 0.525
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.482 0.518
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.482 0.518
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.482 0.518
E00-E07 Disorders of thyroid gland
0.000 0.484 0.516
E88.2 Lipomatosis, not elsewhere classified
0.000 0.484 0.516
E12.9 Without complications
0.000 0.489 0.511
E12.8 With unspecified complications
0.000 0.489 0.511
E12.7 With multiple complications
0.000 0.489 0.511
E12.6 With other specified complications
0.000 0.489 0.511
E12.5 With peripheral circulatory complications
0.000 0.489 0.511
E12.4 With neurological complications
0.000 0.489 0.511
E12.3 With ophthalmic complications
0.000 0.489 0.511
E12.2 With renal complications
0.000 0.489 0.511
E12.1 With ketoacidosis
0.000 0.489 0.511
E12.0 With coma
0.000 0.489 0.511
K80.36 Calculus of bile duct with acute and chronic cholangitis without obstruction
0.509 0.491 0.000
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.491 0.509
E13.8 With unspecified complications
0.000 0.491 0.509
E13.7 With multiple complications
0.000 0.491 0.509
E13.6 With other specified complications
0.000 0.491 0.509
E13.5 With peripheral circulatory complications
0.000 0.491 0.509
E13.4 With neurological complications
0.000 0.491 0.509
E13.2 With renal complications
0.000 0.491 0.509
E13.1 With ketoacidosis
0.000 0.491 0.509
E13.0 With coma
0.000 0.491 0.509
I20.1 Angina pectoris with documented spasm
0.000 0.497 0.503
E15 Nondiabetic hypoglycaemic coma
0.000 0.497 0.502
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.498 0.501
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.498 0.501
E70.2 Disorders of tyrosine metabolism
0.000 0.498 0.501
E70.1 Other hyperphenylalaninaemias
0.000 0.498 0.501
E70.0 Classical phenylketonuria
0.000 0.498 0.501
E75.5 Other lipid storage disorders
0.000 0.503 0.497
E85.8 Other amyloidosis
0.000 0.506 0.494
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.506 0.493
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.506 0.493
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.506 0.493
E74.2 Disorders of galactose metabolism
0.000 0.506 0.493
E74.1 Disorders of fructose metabolism
0.000 0.506 0.493
E71.3 Disorders of fatty-acid metabolism
0.000 0.515 0.485
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.515 0.485
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.515 0.485
E71.0 Maple-syrup-urine disease
0.000 0.515 0.485
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.515 0.485
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.515 0.485
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.515 0.485
E76.2 Other mucopolysaccharidoses
0.000 0.515 0.485
E76.1 Mucopolysaccharidosis, type II
0.000 0.515 0.485
E76.0 Mucopolysaccharidosis, type I
0.000 0.515 0.485
E04 Other non-toxic goitre
0.000 0.518 0.482
E73.8 Other lactose intolerance
0.000 0.518 0.482
E73.1 Secondary lactase deficiency
0.000 0.518 0.482
E73.0 Congenital lactase deficiency
0.000 0.518 0.482
E04.1 Non-toxic single thyroid nodule
0.000 0.518 0.482
E73.9 Lactose intolerance, unspecified
0.000 0.521 0.479
E13.3 With ophthalmic complications
0.000 0.524 0.476
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.000 0.525 0.475
I24.1 Dressler's syndrome
0.000 0.526 0.474
E75.6 Lipid storage disorder, unspecified
0.000 0.527 0.472
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.527 0.472
E75.3 Sphingolipidosis, unspecified
0.000 0.527 0.472
E75.1 Other gangliosidosis
0.000 0.527 0.472
E75.0 GM2 gangliosidosis
0.000 0.527 0.472
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.528 0.472
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.528 0.472
E72.5 Disorders of glycine metabolism
0.000 0.528 0.472
E72.4 Disorders of ornithine metabolism
0.000 0.528 0.472
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.528 0.472
E72.2 Disorders of urea cycle metabolism
0.000 0.528 0.472
E40-E46 Malnutrition
0.001 0.531 0.468
E85.4 Organ-limited amyloidosis
0.000 0.534 0.466
E16.1 Other hypoglycaemia
0.000 0.534 0.466
E74.0 Glycogen storage disease
0.000 0.534 0.465
K80-K87 Disorders of gallbladder, biliary tract and pancreas
0.465 0.535 0.000
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.536 0.464
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.536 0.464
E79.1 Lesch-Nyhan syndrome
0.000 0.536 0.464
E65-E68 Obesity and other hyperalimentation
0.000 0.537 0.463
E14 Unspecified diabetes mellitus
0.000 0.538 0.462
E51 Thiamine deficiency
0.000 0.541 0.459
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.546 0.453
E77.1 Defects in glycoprotein degradation
0.000 0.546 0.453
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.546 0.453
K81 Cholecystitis
0.450 0.550 0.000
I21.4 Acute subendocardial myocardial infarction
0.000 0.553 0.447
K81.1 Chronic cholecystitis
0.443 0.557 0.000
E58 Dietary calcium deficiency
0.000 0.564 0.436
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.565 0.435
E06 Thyroiditis
0.000 0.568 0.432
E87.7 Fluid overload
0.000 0.570 0.430
E75.2 Other sphingolipidosis
0.000 0.575 0.425
E56 Other vitamin deficiencies
0.000 0.577 0.423
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.582 0.417
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.583 0.417
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.583 0.417
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.583 0.417
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.583 0.417
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.583 0.417
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.583 0.417
K80.5 Calculus of bile duct without cholangitis or cholecystitis
0.416 0.584 0.000
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.585 0.415
E50 Vitamin A deficiency
0.000 0.585 0.415
E60 Dietary zinc deficiency
0.000 0.585 0.415
E59 Dietary selenium deficiency
0.000 0.585 0.415
E52 Niacin deficiency [pellagra]
0.000 0.585 0.415
E77.8 Other disorders of glycoprotein metabolism
0.000 0.590 0.409
E54 Ascorbic acid deficiency
0.000 0.592 0.408
E72.0 Disorders of amino-acid transport
0.000 0.595 0.404
E63 Other nutritional deficiencies
0.000 0.597 0.403
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.597 0.402
E10.1 With ketoacidosis
0.000 0.604 0.396
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.609 0.391
E14.2 Withrenal complications
0.000 0.613 0.387
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.619 0.380
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.619 0.380
E16.4 Abnormal secretion of gastrin
0.000 0.619 0.380
E16.3 Increased secretion of glucagon
0.000 0.619 0.380
K85 Acute pancreatitis
0.380 0.620 0.000
E53 Deficiency of other B group vitamins
0.000 0.620 0.380
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.622 0.378
E51.2 Wernicke's encephalopathy
0.000 0.627 0.373
E06.3 Autoimmune thyroiditis
0.000 0.629 0.371
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.630 0.370
E00 Congenital iodine-deficiency syndrome
0.000 0.630 0.370
E14.5 With peripheral circulatory complications
0.000 0.630 0.370
E14.4 With neurological complications
0.000 0.637 0.363
E06.5 Other chronic thyroiditis
0.000 0.640 0.360
E61 Deficiency of other nutrient elements
0.000 0.643 0.357
E65 Localised adiposity
0.000 0.647 0.353
K81.9 Cholecystitis, unspecified
0.351 0.649 0.000
K85.1 Biliary acute pancreatitis
0.350 0.650 0.000
E04.8 Other specified non-toxic goitre
0.000 0.654 0.346
E14.0 With coma
0.000 0.655 0.345
I23.8 Other current complications following acute myocardial infarction
0.000 0.656 0.344
E55 Vitamin D deficiency
0.000 0.656 0.344
E44 Protein-energy malnutrition of moderate and mild degree
0.001 0.664 0.336
E45 Retarded development following protein-energy malnutrition
0.001 0.664 0.336
E43 Unspecified severe protein-energy malnutrition
0.001 0.664 0.336
E42 Marasmic kwashiorkor
0.001 0.664 0.336
E41 Nutritional marasmus
0.001 0.664 0.336
E40 Kwashiorkor
0.001 0.664 0.336
E53.9 Vitamin B deficiency, unspecified
0.000 0.666 0.334
K87 Disorders of gallbladder, biliary tract and pancreas in diseases classified elsewhere
0.333 0.667 0.000
E06.1 Subacute thyroiditis
0.000 0.667 0.333
E67 Other hyperalimentation
0.000 0.668 0.332
E68 Sequelae of hyperalimentation
0.000 0.668 0.332
E14.7 With multiple complications
0.000 0.668 0.331
E51.9 Thiamine deficiency, unspecified
0.000 0.671 0.329
E51.8 Other manifestations of thiamine deficiency
0.000 0.671 0.329
E51.1 Beriberi
0.000 0.671 0.329
E14.8 With unspecified complications
0.000 0.678 0.322
E07 Other disorders of thyroid
0.002 0.680 0.318
E56.1 Deficiency of vitamin K
0.000 0.688 0.312
E06.4 Drug-induced thyroiditis
0.000 0.690 0.310
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.690 0.310
E06.0 Acute thyroiditis
0.000 0.690 0.310
E04.9 Non-toxic goitre, unspecified
0.000 0.694 0.306
E56.9 Vitamin deficiency, unspecified
0.000 0.696 0.303
E56.8 Deficiency of other vitamins
0.000 0.696 0.303
E56.0 Deficiency of vitamin E
0.000 0.696 0.303
K81.8 Other cholecystitis
0.303 0.697 0.000
E50.9 Vitamin A deficiency, unspecified
0.000 0.702 0.297
E50.8 Other manifestations of vitamin A deficiency
0.000 0.702 0.297
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.702 0.297
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.702 0.297
E50.5 Vitamin A deficiency with night blindness
0.000 0.702 0.297
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.702 0.297
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.702 0.297
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.702 0.297
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.702 0.297
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.702 0.297
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.702 0.297
E64.8 Sequelae of other nutritional deficiencies
0.000 0.702 0.297
E64.3 Sequelae of rickets
0.000 0.702 0.297
E64.2 Sequelae of vitamin C deficiency
0.000 0.702 0.297
E64.1 Sequelae of vitamin A deficiency
0.000 0.702 0.297
E64.0 Sequelae of protein-energy malnutrition
0.000 0.702 0.297
E02 Subclinical iodine-deficiency hypothyroidism
0.001 0.707 0.293
K85.2 Alcohol-induced acute pancreatitis
0.292 0.708 0.000
E63.8 Other specified nutritional deficiencies
0.000 0.711 0.289
E63.1 Imbalance of constituents of food intake
0.000 0.711 0.289
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.711 0.289
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.715 0.285
K85.3 Drug-induced acute pancreatitis
0.284 0.715 0.000
E14.6 With other specified complications
0.000 0.717 0.283
E61.2 Magnesium deficiency
0.000 0.719 0.281
E80 Disorders of porphyrin and bilirubin metabolism
0.001 0.719 0.280
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.720 0.280
E63.9 Nutritional deficiency, unspecified
0.000 0.722 0.277
E14.1 With ketoacidosis
0.000 0.724 0.276
E07.8 Other specified disorders of thyroid
0.001 0.724 0.275
E53.1 Pyridoxine deficiency
0.000 0.727 0.273
E53.0 Riboflavin deficiency
0.000 0.727 0.273
K85.0 Idiopathic acute pancreatitis
0.272 0.728 0.000
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.734 0.265
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.734 0.265
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.734 0.265
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.734 0.265
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.734 0.265
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.734 0.265
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.734 0.265
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.734 0.265
K81.0 Acute cholecystitis
0.261 0.739 0.000
E14.3 With ophthalmic complications
0.000 0.741 0.259
I24.8 Other forms of acute ischaemic heart disease
0.000 0.742 0.258
E61.9 Deficiency of nutrient element, unspecified
0.000 0.744 0.256
E61.8 Deficiency of other specified nutrient elements
0.000 0.744 0.256
E61.7 Deficiency of multiple nutrient elements
0.000 0.744 0.256
E61.6 Vanadium deficiency
0.000 0.744 0.256
E61.5 Molybdenum deficiency
0.000 0.744 0.256
E61.4 Chromium deficiency
0.000 0.744 0.256
E61.3 Manganese deficiency
0.000 0.744 0.256
E61.0 Copper deficiency
0.000 0.744 0.256
E55.0 Rickets, active
0.000 0.753 0.246
E44.1 Mild protein-energy malnutrition
0.001 0.759 0.241
E44.0 Moderate protein-energy malnutrition
0.001 0.759 0.241
K87.1 Disorders of pancreas in diseases classified elsewhere
0.239 0.761 0.000
K87.0 Disorders of gallbladder and biliary tract in diseases classified elsewhere
0.239 0.761 0.000
E67.8 Other specified hyperalimentation
0.000 0.762 0.238
E67.3 Hypervitaminosis D
0.000 0.762 0.238
E67.2 Megavitamin-B6 syndrome
0.000 0.762 0.238
E67.1 Hypercarotenaemia
0.000 0.762 0.238
E67.0 Hypervitaminosis A
0.000 0.762 0.238
K82 Other diseases of gallbladder
0.231 0.769 0.000
E07.1 Dyshormogenetic goitre
0.001 0.771 0.228
E07.0 Hypersecretion of calcitonin
0.001 0.771 0.228
K86 Other diseases of pancreas
0.227 0.773 0.000
E04.0 Non-toxic diffuse goitre
0.000 0.780 0.220
K80.0 Calculus of gallbladder with acute cholecystitis
0.215 0.785 0.000
K85.8 Other acute pancreatitis
0.213 0.786 0.000
K86.2 Cyst of pancreas
0.206 0.794 0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.795 0.205
E89.5 Postprocedural testicular hypofunction
0.000 0.796 0.204
E89.1 Postprocedural hypoinsulinaemia
0.000 0.796 0.204
E16.2 Hypoglycaemia, unspecified
0.000 0.798 0.202
E80.5 Crigler-Najjar syndrome
0.001 0.799 0.201
E80.3 Defects of catalase and peroxydase
0.001 0.799 0.201
E80.0 Hereditary erythropoietic porphyria
0.001 0.799 0.201
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.801 0.199
K82.4 Cholesterolosis of gallbladder
0.198 0.802 0.000
E89.3 Postprocedural hypopituitarism
0.000 0.802 0.198
E80.6 Other disorders of bilirubin metabolism
0.000 0.804 0.195
K85.9 Acute pancreatitis, unspecified
0.193 0.807 0.000
E89.4 Postprocedural ovarian failure
0.000 0.811 0.189
E80.2 Other porphyria
0.001 0.813 0.186
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.814 0.185
E06.9 Thyroiditis, unspecified
0.001 0.818 0.182
K82.1 Hydrops of gallbladder
0.181 0.819 0.000
E80.1 Porphyria cutanea tarda
0.001 0.823 0.176
E80.7 Disorder of bilirubin metabolism, unspecified
0.001 0.824 0.176
E55.9 Vitamin D deficiency, unspecified
0.000 0.825 0.175
K82.0 Obstruction of gallbladder
0.175 0.825 0.000
K86.1 Other chronic pancreatitis
0.167 0.833 0.000
K82.3 Fistula of gallbladder
0.164 0.836 0.000
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.837 0.163
I20.9 Angina pectoris, unspecified
0.000 0.840 0.160
E89.0 Postprocedural hypothyroidism
0.000 0.843 0.157
K86.0 Alcohol-induced chronic pancreatitis
0.153 0.847 0.000
E20-E35 Disorders of other endocrine glands
0.000 0.853 0.147
E61.1 Iron deficiency
0.000 0.854 0.146
E83 Disorders of mineral metabolism
0.000 0.862 0.138
E04.2 Non-toxic multinodular goitre
0.000 0.867 0.133
E46 Unspecified protein-energy malnutrition
0.001 0.868 0.131
K86.8 Other specified diseases of pancreas
0.130 0.870 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.874 0.126
E27 Other disorders of adrenal gland
0.000 0.874 0.126
K82.8 Other specified diseases of gallbladder
0.122 0.878 0.000
E26 Hyperaldosteronism
0.000 0.880 0.120
E27.9 Disorder of adrenal gland, unspecified
0.000 0.881 0.119
K82.2 Perforation of gallbladder
0.117 0.882 0.000
E89.2 Postprocedural hypoparathyroidism
0.000 0.885 0.115
E29 Testicular dysfunction
0.000 0.885 0.115
E83.4 Disorders of magnesium metabolism
0.000 0.887 0.113
E27.2 Addisonian crisis
0.000 0.889 0.111
E31 Polyglandular dysfunction
0.000 0.892 0.108
E03 Other hypothyroidism
0.001 0.893 0.106
E25 Adrenogenital disorders
0.000 0.893 0.106
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.894 0.105
E30 Disorders of puberty, not elsewhere classified
0.000 0.894 0.105
E32 Diseases of thymus
0.000 0.895 0.105
E20 Hypoparathyroidism
0.000 0.898 0.102
E26.0 Primary hyperaldosteronism
0.000 0.899 0.100
E83.8 Other disorders of mineral metabolism
0.000 0.901 0.099
E83.2 Disorders of zinc metabolism
0.000 0.901 0.099
E83.0 Disorders of copper metabolism
0.000 0.901 0.099
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.902 0.097
K86.3 Pseudocyst of pancreas
0.096 0.904 0.000
E34 Other endocrine disorders
0.000 0.904 0.096
E05.5 Thyroid crisis or storm
0.000 0.909 0.090
E05.4 Thyrotoxicosis factitia
0.000 0.909 0.090
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.909 0.090
E27.5 Adrenomedullary hyperfunction
0.000 0.910 0.090
E27.0 Other adrenocortical overactivity
0.000 0.910 0.090
E29.9 Testicular dysfunction, unspecified
0.000 0.910 0.090
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.910 0.090
E26.9 Hyperaldosteronism, unspecified
0.000 0.912 0.088
E26.8 Other hyperaldosteronism
0.000 0.913 0.086
E26.1 Secondary hyperaldosteronism
0.000 0.913 0.086
E29.1 Testicular hypofunction
0.000 0.914 0.086
E03.1 Congenital hypothyroidism without goitre
0.001 0.915 0.084
E03.0 Congenital hypothyroidism with diffuse goitre
0.001 0.917 0.083
E29.8 Other testicular dysfunction
0.000 0.917 0.083
E29.0 Testicular hyperfunction
0.000 0.917 0.083
E31.0 Autoimmune polyglandular failure
0.000 0.919 0.081
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.920 0.080
E27.8 Other specified disorders of adrenal gland
0.000 0.920 0.080
E34.3 Short stature, not elsewhere classified
0.000 0.922 0.078
E31.9 Polyglandular dysfunction, unspecified
0.000 0.922 0.078
E31.8 Other polyglandular dysfunction
0.000 0.922 0.078
E31.1 Polyglandular hyperfunction
0.000 0.922 0.078
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.922 0.077
K86.9 Disease of pancreas, unspecified
0.077 0.923 0.000
E03.5 Myxoedema coma
0.001 0.923 0.076
E03.4 Atrophy of thyroid (acquired)
0.001 0.923 0.076
E03.3 Postinfectious hypothyroidism
0.001 0.923 0.076
E25.9 Adrenogenital disorder, unspecified
0.000 0.923 0.076
E25.8 Other adrenogenital disorders
0.000 0.923 0.076
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.923 0.076
E30.9 Disorder of puberty, unspecified
0.000 0.924 0.076
E30.8 Other disorders of puberty
0.000 0.924 0.076
E30.1 Precocious puberty
0.000 0.924 0.076
E30.0 Delayed puberty
0.000 0.924 0.076
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.924 0.076
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.924 0.076
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.924 0.076
E32.9 Disease of thymus, unspecified
0.000 0.925 0.075
E32.1 Abscess of thymus
0.000 0.925 0.075
E32.0 Persistent hyperplasia of thymus
0.000 0.925 0.075
E32.8 Other diseases of thymus
0.000 0.926 0.074
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.926 0.074
E22 Hyperfunction of pituitary gland
0.000 0.926 0.074
E34.8 Other specified endocrine disorders
0.000 0.926 0.073
E20.8 Other hypoparathyroidism
0.000 0.927 0.073
E20.1 Pseudohypoparathyroidism
0.000 0.927 0.073
E20.0 Idiopathic hypoparathyroidism
0.000 0.927 0.073
E05.8 Other thyrotoxicosis
0.000 0.927 0.073
E20.9 Hypoparathyroidism, unspecified
0.000 0.930 0.070
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.931 0.069
E34.5 Androgen resistance syndrome
0.000 0.931 0.069
E34.4 Constitutional tall stature
0.000 0.931 0.069
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.931 0.069
E34.1 Other hypersecretion of intestinal hormones
0.000 0.931 0.069
E10.9 Without complications
0.000 0.932 0.068
T84.1 Mechanical complication of internal fixation device of bones of limb
0.064 0.936 0.000
E80.4 Gilbert's syndrome
0.001 0.937 0.063
E05.9 Thyrotoxicosis, unspecified
0.000 0.937 0.063
K82.9 Disease of gallbladder, unspecified
0.062 0.937 0.001
E66 Obesity
0.000 0.942 0.058
E28 Ovarian dysfunction
0.000 0.942 0.058
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.942 0.057
E34.0 Carcinoid syndrome
0.000 0.945 0.055
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.945 0.055
E27.1 Primary adrenocortical insufficiency
0.000 0.947 0.053
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.947 0.053
E22.8 Other hyperfunction of pituitary gland
0.000 0.947 0.053
E22.0 Acromegaly and pituitary gigantism
0.000 0.947 0.053
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.001 0.947 0.052
E34.9 Endocrine disorder, unspecified
0.000 0.948 0.052
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.001 0.948 0.051
E24 Cushing's syndrome
0.001 0.950 0.049
E53.8 Deficiency of other specified B group vitamins
0.000 0.951 0.049
E21.4 Other specified disorders of parathyroid gland
0.000 0.952 0.048
E21.2 Other hyperparathyroidism
0.000 0.953 0.047
E22.1 Hyperprolactinaemia
0.000 0.954 0.045
E66.0 Obesity due to excess calories
0.000 0.957 0.043
E66.1 Drug-induced obesity
0.000 0.958 0.042
E28.9 Ovarian dysfunction, unspecified
0.000 0.958 0.042
E28.8 Other ovarian dysfunction
0.000 0.958 0.042
E28.1 Androgen excess
0.000 0.958 0.042
E28.0 Oestrogen excess
0.000 0.958 0.042
E86 Volume depletion
0.000 0.960 0.040
E14.9 Without complications
0.000 0.961 0.039
E23 Hypofunction and other disorders of pituitary gland
0.000 0.962 0.038
E83.3 Disorders of phosphorus metabolism
0.000 0.962 0.038
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.964 0.036
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.001 0.964 0.035
E24.3 Ectopic ACTH syndrome
0.001 0.964 0.035
E24.1 Nelson's syndrome
0.001 0.964 0.035
I95.1 Orthostatic hypotension
0.000 0.964 0.036
E83.1 Disorders of iron metabolism
0.000 0.964 0.036
E24.2 Drug-induced Cushing's syndrome
0.001 0.966 0.033
E87.1 Hypo-osmolality and hyponatraemia
0.000 0.966 0.034
E24.8 Other Cushing's syndrome
0.001 0.967 0.032
E24.0 Pituitary-dependent Cushing's disease
0.001 0.968 0.031
E28.3 Primary ovarian failure
0.000 0.968 0.031
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.969 0.031
I80.2 Phlebitis and thrombophlebitis of other deep vessels of lower extremities
0.031 0.969 0.000
E03.8 Other specified hypothyroidism
0.002 0.970 0.027
K83 Other diseases of biliary tract
0.028 0.972 0.000
E23.1 Drug-induced hypopituitarism
0.000 0.972 0.027
E21.3 Hyperparathyroidism, unspecified
0.000 0.972 0.028
E07.9 Disorder of thyroid, unspecified
0.007 0.973 0.020
E23.7 Disorder of pituitary gland, unspecified
0.000 0.973 0.027
E21.0 Primary hyperparathyroidism
0.000 0.973 0.027
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.974 0.026
E23.6 Other disorders of pituitary gland
0.000 0.975 0.025

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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