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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2395165
log Bayes Factor = 231.325
Chromosome 6   position 32,388,144  (GRCh37) Explore rs2395165 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E10.1 With ketoacidosis
0.000 0.000 1.000
E16.2 Hypoglycaemia, unspecified
0.000 0.000 1.000
H36.0 Diabetic retinopathy
0.000 0.000 1.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
L40 Psoriasis
0.000 0.000 1.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
M05-M14 Inflammatory polyarthropathies
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
# Top node
0.000 0.000 1.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
I10-I15 Hypertensive diseases
0.000 0.000 1.000
L40-L45 Papulosquamous disorders
0.000 0.000 1.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.000 1.000
Chapter IX Diseases of the circulatory system
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
E10.4 With neurological complications
0.000 0.000 1.000
M05 Seropositive rheumatoid arthritis
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E16 Other disorders of pancreatic internal secretion
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.000 1.000
E14.9 Without complications
0.000 0.000 1.000
I10 Essential (primary) hypertension
0.000 0.000 1.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.000 1.000
E11.3 With ophthalmic complications
0.000 0.000 1.000
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
E78.0 Pure hypercholesterolaemia
0.000 0.001 0.999
M35.3 Polymyalgia rheumatica
0.000 0.001 0.999
J33.9 Nasal polyp, unspecified
0.000 0.001 0.999
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.001 0.999
E14.3 With ophthalmic complications
0.000 0.001 0.999
I22 Subsequent myocardial infarction
0.000 0.001 0.999
J33 Nasal polyp
0.000 0.001 0.999
E70-E90 Metabolic disorders
0.000 0.001 0.999
E10.5 With peripheral circulatory complications
0.000 0.002 0.998
H36 Retinal disorders in diseases classified elsewhere
0.000 0.002 0.998
G35-G37 Demyelinating diseases of the central nervous system
0.997 0.002 0.001
L40.9 Psoriasis, unspecified
0.000 0.003 0.997
H30-H36 Disorders of choroid and retina
0.000 0.003 0.997
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.003 0.997
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.003 0.997
G37 Other demyelinating diseases of central nervous system
0.996 0.004 0.000
Chapter VII Diseases of the eye and adnexa
0.000 0.005 0.995
G37.9 Demyelinating disease of central nervous system, unspecified
0.995 0.005 0.000
J33.0 Polyp of nasal cavity
0.000 0.006 0.994
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.006 0.994
M35 Other systemic involvement of connective tissue
0.000 0.007 0.993
L43 Lichen planus
0.000 0.008 0.992
M20-M25 Other joint disorders
0.000 0.010 0.990
M07 Psoriatic and enteropathic arthropathies
0.000 0.011 0.989
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.011 0.989
J33.8 Other polyp of sinus
0.000 0.012 0.988
E11.1 With ketoacidosis
0.000 0.014 0.986
I12 Hypertensive renal disease
0.000 0.017 0.983
M07.3 Other psoriatic arthropathies
0.000 0.018 0.982
E06 Thyroiditis
0.000 0.018 0.982
L43.9 Lichen planus, unspecified
0.000 0.020 0.980
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.020 0.980
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.021 0.979
E10.2 With renal complications
0.000 0.023 0.977
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.024 0.976
E06.3 Autoimmune thyroiditis
0.000 0.029 0.971
I12.9 Hypertensive renal disease without renal failure
0.000 0.031 0.969
I20 Angina pectoris
0.000 0.032 0.968
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.034 0.966
Chapter VIII Diseases of the ear and mastoid process
0.000 0.036 0.964
L80-L99 Other disorders of the skin and subcutaneous tissue
0.000 0.045 0.955
H60-H62 Diseases of external ear
0.000 0.047 0.953
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.049 0.951
H40-H42 Glaucoma
0.000 0.050 0.950
L97 Ulcer of lower limb, not elsewhere classified
0.000 0.052 0.948
H35 Other retinal disorders
0.000 0.053 0.947
M06.0 Seronegative rheumatoid arthritis
0.000 0.054 0.946
M06.3 Rheumatoid nodule
0.000 0.057 0.943
M45-M49 Spondylopathies
0.000 0.061 0.939
M45 Ankylosing spondylitis
0.000 0.061 0.939
H35.8 Other specified retinal disorders
0.000 0.062 0.938
E10.8 With unspecified complications
0.000 0.064 0.936
H61 Other disorders of external ear
0.000 0.065 0.935
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.072 0.928
I20.9 Angina pectoris, unspecified
0.000 0.080 0.920
M65-M68 Disorders of synovium and tendon
0.000 0.081 0.919
E78.2 Mixed hyperlipidaemia
0.000 0.081 0.919
H40 Glaucoma
0.000 0.083 0.917
H40.9 Glaucoma, unspecified
0.000 0.084 0.916
L80 Vitiligo
0.000 0.087 0.913
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.089 0.911
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.096 0.904
E11.5 With peripheral circulatory complications
0.000 0.097 0.903
H43-H45 Disorders of vitreous body and globe
0.000 0.097 0.903
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.098 0.902
M34 Systemic sclerosis
0.000 0.099 0.901
E11.2 With renal complications
0.000 0.103 0.897
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.103 0.897
H61.0 Perichondritis of external ear
0.000 0.104 0.896
I20.0 Unstable angina
0.000 0.106 0.894
M65 Synovitis and tenosynovitis
0.000 0.109 0.891
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.110 0.890
M06.4 Inflammatory polyarthropathy
0.000 0.113 0.887
L85 Other epidermal thickening
0.000 0.115 0.885
L92 Granulomatous disorders of skin and subcutaneous tissue
0.000 0.119 0.881
H43 Disorders of vitreous body
0.000 0.124 0.876
H34 Retinal vascular occlusions
0.000 0.124 0.876
M31 Other necrotising vasculopathies
0.000 0.124 0.876
H35.4 Peripheral retinal degeneration
0.000 0.132 0.868
L57 Skin changes due to chronic exposure to nonionising radiation
0.000 0.132 0.868
E07 Other disorders of thyroid
0.000 0.133 0.867
L43.8 Other lichen planus
0.000 0.137 0.863
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.140 0.860
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.143 0.857
L85.8 Other specified epidermal thickening
0.000 0.144 0.856
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.146 0.854
E78.1 Pure hyperglyceridaemia
0.000 0.147 0.853
M65.9 Synovitis and tenosynovitis, unspecified
0.000 0.148 0.852
M06.34 Rheumatoid nodule (Hand)
0.000 0.149 0.851
H61.8 Other specified disorders of external ear
0.000 0.153 0.847
E89.0 Postprocedural hypothyroidism
0.000 0.153 0.847
H60 Otitis externa
0.000 0.153 0.847
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.153 0.847
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.156 0.844
L57.0 Actinic keratosis
0.000 0.159 0.841
L40.8 Other psoriasis
0.000 0.161 0.839
M65.4 Radial styloid tenosynovitis [de Quervain]
0.000 0.162 0.838
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.164 0.836
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.165 0.835
I15 Secondary hypertension
0.000 0.168 0.832
M80-M85 Disorders of bone density and structure
0.000 0.171 0.829
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.175 0.825
M35.7 Hypermobility syndrome
0.000 0.175 0.825
E10.6 With other specified complications
0.000 0.177 0.823
M31.6 Other giant cell arteritis
0.000 0.178 0.822
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.178 0.822
Chapter VI Diseases of the nervous system
0.015 0.181 0.804
I20.1 Angina pectoris with documented spasm
0.000 0.181 0.819
L92.3 Foreign body granuloma of skin and subcutaneous tissue
0.000 0.187 0.813
G37.8 Other specified demyelinating diseases of central nervous system
0.811 0.189 0.000
M65.94 Synovitis and tenosynovitis, unspecified (Hand)
0.000 0.189 0.811
E88 Other metabolic disorders
0.000 0.190 0.810
M35.1 Other overlap syndromes
0.000 0.190 0.810
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.194 0.806
E11.8 With unspecified complications
0.000 0.194 0.806
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.197 0.803
E14.4 With neurological complications
0.000 0.198 0.802
E78.6 Lipoprotein deficiency
0.000 0.198 0.801
G50-G59 Nerve, nerve root and plexus disorders
0.001 0.206 0.794
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.002 0.206 0.793
H65-H75 Diseases of middle ear and mastoid
0.000 0.208 0.792
H43.3 Other vitreous opacities
0.000 0.209 0.791
M80 Osteoporosis with pathological fracture
0.000 0.210 0.790
G59 Mononeuropathy in diseases classified elsewhere
0.000 0.212 0.788
M34.1 CR(E)ST syndrome
0.000 0.212 0.788
G56.0 Carpal tunnel syndrome
0.000 0.214 0.786
H61.1 Non-infective disorders of pinna
0.000 0.214 0.786
G59.0 Diabetic mononeuropathy
0.000 0.216 0.784
G56 Mononeuropathies of upper limb
0.000 0.217 0.783
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.219 0.781
M65.43 Radial styloid tenosynovitis [de Quervain] (Forearm)
0.000 0.221 0.779
E11.4 With neurological complications
0.000 0.223 0.777
E03.8 Other specified hypothyroidism
0.000 0.226 0.773
M35.2 Behcet's disease
0.000 0.227 0.773
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.227 0.773
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.228 0.772
M80.9 Unspecified osteoporosis with pathological fracture
0.000 0.230 0.770
G63 Polyneuropathy in diseases classified elsewhere
0.001 0.230 0.769
E14.5 With peripheral circulatory complications
0.000 0.231 0.769
E11.6 With other specified complications
0.000 0.232 0.768
H43.8 Other disorders of vitreous body
0.000 0.237 0.763
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.763 0.237 0.000
M34.9 Systemic sclerosis, unspecified
0.000 0.239 0.761
M82 Osteoporosis in diseases classified elsewhere
0.000 0.241 0.759
H35.2 Other proliferative retinopathy
0.000 0.241 0.759
I24 Other acute ischaemic heart diseases
0.000 0.243 0.757
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.246 0.754
I12.0 Hypertensive renal disease with renal failure
0.000 0.246 0.754
G63.2 Diabetic polyneuropathy
0.000 0.248 0.752
E07.9 Disorder of thyroid, unspecified
0.000 0.249 0.751
L94 Other localised connective tissue disorders
0.000 0.250 0.750
E20-E35 Disorders of other endocrine glands
0.000 0.255 0.745
M65.93 Synovitis and tenosynovitis, unspecified (Forearm)
0.000 0.256 0.744
G61 Inflammatory polyneuropathy
0.000 0.257 0.742
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.258 0.742
E13 Other specified diabetes mellitus
0.000 0.258 0.742
E74 Other disorders of carbohydrate metabolism
0.000 0.259 0.741
M30 Polyarteritis nodosa and related conditions
0.000 0.260 0.740
H34.8 Other retinal vascular occlusions
0.000 0.263 0.737
H60.3 Other infective otitis externa
0.000 0.267 0.733
E83 Disorders of mineral metabolism
0.282 0.272 0.446
H40.4 Glaucoma secondary to eye inflammation
0.000 0.274 0.726
L92.9 Granulomatous disorder of skin and subcutaneous tissue, unspecified
0.000 0.274 0.726
E14.2 Withrenal complications
0.000 0.277 0.722
E16.1 Other hypoglycaemia
0.000 0.281 0.719
H72 Perforation of tympanic membrane
0.000 0.282 0.718
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.283 0.717
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.283 0.717
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.283 0.717
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.283 0.717
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.283 0.717
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E10.0 With coma
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
E14.8 With unspecified complications
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E14.6 With other specified complications
0.000 0.283 0.717
E14.1 With ketoacidosis
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.000 0.283 0.717
L40.3 Pustulosis palmaris et plantaris
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
L40.1 Generalised pustular psoriasis
0.000 0.283 0.717
M06.8 Other specified rheumatoid arthritis
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M06.1 Adult-onset Still's disease
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
L44 Other papulosquamous disorders
0.000 0.283 0.717
L41 Parapsoriasis
0.000 0.283 0.717
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.283 0.717
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.283 0.717
M08 Juvenile arthritis
0.000 0.283 0.717
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
I13 Hypertensive heart and renal disease
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
M05.8 Other seropositive rheumatoid arthritis
0.000 0.283 0.717
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.283 0.717
M05.2 Rheumatoid vasculitis
0.000 0.283 0.717
M05.1 Rheumatoid lung disease
0.000 0.283 0.717
M05.0 Felty's syndrome
0.000 0.283 0.717
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.283 0.717
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.283 0.717
E16.4 Abnormal secretion of gastrin
0.000 0.283 0.717
E16.3 Increased secretion of glucagon
0.000 0.283 0.717
E15 Nondiabetic hypoglycaemic coma
0.000 0.283 0.717
M65.90 Synovitis and tenosynovitis, unspecified (Multiple sites)
0.000 0.283 0.717
E78.3 Hyperchylomicronaemia
0.000 0.284 0.716
J33.1 Polypoid sinus degeneration
0.000 0.284 0.716
E77 Disorders of glycoprotein metabolism
0.000 0.284 0.716
E76 Disorders of glycosaminoglycan metabolism
0.000 0.284 0.716
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.284 0.716
E70 Disorders of aromatic amino-acid metabolism
0.000 0.284 0.716
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.284 0.716
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.284 0.716
G36 Other acute disseminated demyelination
0.715 0.284 0.001
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.285 0.715
G37.5 Concentric sclerosis [Balo]
0.714 0.286 0.000
G37.4 Subacute necrotising myelitis
0.714 0.286 0.000
G37.2 Central pontine myelinolysis
0.714 0.286 0.000
G37.1 Central demyelination of corpus callosum
0.714 0.286 0.000
G37.0 Diffuse sclerosis
0.714 0.286 0.000
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.288 0.712
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.288 0.712
M35.5 Multifocal fibrosclerosis
0.000 0.288 0.712
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.288 0.712
M80.90 Unspecified osteoporosis with pathological fracture (Multiple sites)
0.000 0.288 0.712
L40.0 Psoriasis vulgaris
0.000 0.289 0.711
L43.3 Subacute (active) lichen planus
0.000 0.289 0.711
L43.2 Lichenoid drug reaction
0.000 0.289 0.711
L43.1 Bullous lichen planus
0.000 0.289 0.711
L43.0 Hypertrophic lichen planus
0.000 0.289 0.711
M65.92 Synovitis and tenosynovitis, unspecified (Upper arm)
0.000 0.289 0.711
L92.0 Granuloma annulare
0.000 0.289 0.711
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.000 0.290 0.710
M82.1 Osteoporosis in endocrine disorders
0.000 0.290 0.710
I05-I09 Chronic rheumatic heart diseases
0.000 0.291 0.709
M07.5 Arthropathy in ulcerative colitis
0.000 0.291 0.709
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.291 0.709
M07.2 Psoriatic spondylitis
0.000 0.291 0.709
M07.1 Arthritis mutilans
0.000 0.291 0.709
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.291 0.709
M14 Arthropathies in other diseases classified elsewhere
0.000 0.291 0.708
H43.9 Disorder of vitreous body, unspecified
0.000 0.292 0.708
L10-L14 Bullous disorders
0.000 0.293 0.707
H35.6 Retinal haemorrhage
0.000 0.294 0.706
H40.5 Glaucoma secondary to other eye disorders
0.000 0.294 0.706
M07.38 Other psoriatic arthropathies (Other)
0.000 0.296 0.704
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.296 0.704
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.296 0.704
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.296 0.704
E06.5 Other chronic thyroiditis
0.000 0.296 0.704
E06.4 Drug-induced thyroiditis
0.000 0.296 0.704
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.296 0.704
E06.1 Subacute thyroiditis
0.000 0.296 0.704
E06.0 Acute thyroiditis
0.000 0.296 0.704
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.299 0.701
I25 Chronic ischaemic heart disease
0.000 0.300 0.700
M49 Spondylopathies in diseases classified elsewhere
0.000 0.300 0.700
I00-I02 Acute rheumatic fever
0.000 0.301 0.699
I22.8 Subsequent myocardial infarction of other sites
0.000 0.303 0.697
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.306 0.694
H61.3 Acquired stenosis of external ear canal
0.000 0.306 0.694
H43.2 Crystalline deposits in vitreous body
0.000 0.306 0.694
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.309 0.691
H30 Chorioretinal inflammation
0.000 0.313 0.687
M65.44 Radial styloid tenosynovitis [de Quervain] (Hand)
0.000 0.313 0.687
H34.2 Other retinal artery occlusions
0.000 0.313 0.687
M65.1 Other infective (teno)synovitis
0.000 0.313 0.686
L99 Other disorders of skin and subcutaneous tissue in diseases classified elsewhere
0.000 0.315 0.685
L87 Transepidermal elimination disorders
0.000 0.315 0.685
L86 Keratoderma in diseases classified elsewhere
0.000 0.315 0.685
I21 Acute myocardial infarction
0.000 0.315 0.685
L56 Other acute skin changes due to ultraviolet radiation
0.000 0.316 0.684
H62 Disorders of external ear in diseases classified elsewhere
0.000 0.316 0.684
E89.2 Postprocedural hypoparathyroidism
0.000 0.317 0.683
H60.1 Cellulitis of external ear
0.000 0.317 0.683
H42 Glaucoma in diseases classified elsewhere
0.000 0.319 0.681
I15.1 Hypertension secondary to other renal disorders
0.000 0.319 0.681
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.320 0.680
M31.5 Giant cell arteritis with polymyalgia rheumatica
0.000 0.320 0.680
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.321 0.679
E28 Ovarian dysfunction
0.000 0.321 0.679
E84 Cystic fibrosis
0.000 0.321 0.679
H35.1 Retinopathy of prematurity
0.000 0.321 0.679
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.322 0.678
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.322 0.678
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.322 0.678
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.322 0.678
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.322 0.678
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.322 0.678
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.324 0.676
M06.38 Rheumatoid nodule (Other)
0.000 0.324 0.676
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.324 0.676
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.324 0.676
M06.33 Rheumatoid nodule (Forearm)
0.000 0.324 0.676
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.324 0.676
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.324 0.676
L95 Vasculitis limited to skin, not elsewhere classified
0.000 0.326 0.673
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.327 0.673
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.327 0.673
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.327 0.673
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.327 0.673
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.327 0.673
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.327 0.673
E40-E46 Malnutrition
0.000 0.329 0.671
E11.0 With coma
0.000 0.329 0.671
H60.9 Otitis externa, unspecified
0.000 0.330 0.670
E89.4 Postprocedural ovarian failure
0.000 0.333 0.667
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.334 0.666
M12 Other specific arthropathies
0.000 0.335 0.665
E79 Disorders of purine and pyrimidine metabolism
0.000 0.335 0.664
E06.9 Thyroiditis, unspecified
0.000 0.336 0.664
E07.8 Other specified disorders of thyroid
0.000 0.336 0.663
L83 Acanthosis nigricans
0.000 0.337 0.663
I25.5 Ischaemic cardiomyopathy
0.000 0.338 0.662
M80.98 Unspecified osteoporosis with pathological fracture (Other)
0.000 0.338 0.662
M80.99 Unspecified osteoporosis with pathological fracture (Site unspecified)
0.000 0.339 0.661
I23 Certain current complications following acute myocardial infarction
0.000 0.339 0.660
E73 Lactose intolerance
0.000 0.341 0.659
M07.6 Other enteropathic arthropathies
0.000 0.341 0.659
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.000 0.341 0.659
I15.9 Seconday hypertension, unspecified
0.000 0.341 0.659
I25.1 Atherosclerotic heart disease
0.000 0.342 0.658
H40.6 Glaucoma secondary to drugs
0.000 0.342 0.658
H40.3 Glaucoma secondary to eye trauma
0.000 0.342 0.658
H34.9 Retinal vascular occlusion, unspecified
0.000 0.343 0.657
M31.3 Wegener's granulomatosis
0.000 0.343 0.657
H72.0 Central perforation of tympanic membrane
0.000 0.344 0.656
E72 Other disorders of amino-acid metabolism
0.000 0.344 0.655
L42 Pityriasis rosea
0.000 0.345 0.655
H35.7 Separation of retinal layers
0.000 0.346 0.654
M60-M63 Disorders of muscles
0.000 0.346 0.653
L55 Sunburn
0.000 0.347 0.653
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.350 0.650
H45 Disorders of vitreous body and globe in diseases classified elsewhere
0.000 0.353 0.647
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.353 0.647
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.353 0.647
E89.5 Postprocedural testicular hypofunction
0.000 0.353 0.647
E89.1 Postprocedural hypoinsulinaemia
0.000 0.353 0.647
H34.1 Central retinal artery occlusion
0.000 0.353 0.647
E89.3 Postprocedural hypopituitarism
0.000 0.354 0.646
M34.2 Systemic sclerosis induced by drugs and chemicals
0.000 0.354 0.646
M34.0 Progressive systemic sclerosis
0.000 0.354 0.646
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.356 0.644
D64.9 Anaemia, unspecified
0.000 0.358 0.642
M82.10 Osteoporosis in endocrine disorders (Multiple sites)
0.000 0.359 0.641
H60.4 Cholesteatoma of external ear
0.000 0.360 0.640
E86 Volume depletion
0.000 0.360 0.640
M34.8 Other forms of systemic sclerosis
0.000 0.361 0.638
M65.2 Calcific tendinitis
0.000 0.361 0.638
M65.0 Abscess of tendon sheath
0.000 0.361 0.638
H74 Other disorders of middle ear and mastoid
0.000 0.362 0.638
G51 Facial nerve disorders
0.000 0.363 0.636
G52 Disorders of other cranial nerves
0.001 0.364 0.636
L57.9 Skin changes due to chronic exposure to nonionising radiation, unspecified
0.000 0.364 0.636
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.364 0.636
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.364 0.636
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.364 0.636
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.364 0.636
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.364 0.636
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.364 0.636
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.364 0.636
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.364 0.636
E23 Hypofunction and other disorders of pituitary gland
0.000 0.365 0.635
L85.3 Xerosis cutis
0.000 0.366 0.634
L85.2 Keratosis punctata (palmaris et plantaris)
0.000 0.366 0.634
L85.0 Acquired ichthyosis
0.000 0.366 0.634
H60.5 Acute otitis externa, non-infective
0.000 0.367 0.633
H43.1 Vitreous haemorrhage
0.000 0.368 0.632
L92.2 Granuloma faciale [eosinophilic granuloma of skin]
0.000 0.368 0.632
L92.1 Necrobiosis lipoidica, not elsewhere classified
0.000 0.368 0.632
G61.8 Other inflammatory polyneuropathies
0.000 0.369 0.631
M31.9 Necrotising vasculopathy, unspecified
0.000 0.370 0.630
M66 Spontaneous rupture of synovium and tendon
0.000 0.371 0.629
H43.0 Vitreous prolapse
0.000 0.372 0.628
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.372 0.628
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.372 0.628
H34.0 Transient retinal artery occlusion
0.000 0.372 0.628
M31.8 Other specified necrotising vasculopathies
0.000 0.372 0.628
M31.7 Microscopic polyangiitis
0.000 0.372 0.628
M31.4 Aortic arch syndrome [Takayasu]
0.000 0.372 0.628
M31.2 Lethal midline granuloma
0.000 0.372 0.628
G61.9 Inflammatory polyneuropathy, unspecified
0.000 0.374 0.625
M65.95 Synovitis and tenosynovitis, unspecified (Pelvic region and thigh)
0.000 0.377 0.623
L57.5 Actinic granuloma
0.000 0.377 0.622
L57.3 Poikiloderma of Civatte
0.000 0.377 0.622
L57.2 Cutis rhomboidalis nuchae
0.000 0.377 0.622
L57.1 Actinic reticuloid
0.000 0.377 0.622
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.378 0.622
E05.8 Other thyrotoxicosis
0.000 0.379 0.621
E07.1 Dyshormogenetic goitre
0.000 0.379 0.621
E07.0 Hypersecretion of calcitonin
0.000 0.379 0.621
H66 Suppurative and unspecified otitis media
0.000 0.380 0.620
G61.0 Guillain-Barre syndrome
0.000 0.381 0.619
D64 Other anaemias
0.000 0.382 0.618
G53 Cranial nerve disorders in diseases classified elsewhere
0.001 0.383 0.617
H80-H83 Diseases of inner ear
0.000 0.384 0.616
E88.8 Other specified metabolic disorders
0.000 0.384 0.616
E03.1 Congenital hypothyroidism without goitre
0.000 0.384 0.615
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.388 0.612
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.388 0.611
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.389 0.611
M65.98 Synovitis and tenosynovitis, unspecified (Other)
0.000 0.389 0.611
E88.2 Lipomatosis, not elsewhere classified
0.000 0.389 0.611
L57.4 Cutis laxa senilis
0.000 0.390 0.610
D60-D64 Aplastic and other anaemias
0.000 0.391 0.609
H40.1 Primary open-angle glaucoma
0.000 0.392 0.608
H60.2 Malignant otitis externa
0.000 0.393 0.607
M11 Other crystal arthropathies
0.000 0.393 0.607
H66.3 Other chronic suppurative otitis media
0.000 0.393 0.607
M32 Systemic lupus erythematosus
0.000 0.394 0.606
L94.2 Calcinosis cutis
0.000 0.394 0.606
M82.11 Osteoporosis in endocrine disorders (Shoulder region)
0.000 0.395 0.605
G60 Hereditary and idiopathic neuropathy
0.001 0.395 0.604
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.000 0.395 0.604
L85.1 Acquired keratosis [keratoderma] palmaris et plantaris
0.000 0.397 0.603
E29 Testicular dysfunction
0.000 0.397 0.603
M80.1 Postoophorectomy osteoporosis with pathological fracture
0.000 0.398 0.602
M65.49 Radial styloid tenosynovitis [de Quervain]-Site unspec
0.000 0.399 0.601
M65.48 Radial styloid tenosynovitis [de Quervain]-Other
0.000 0.399 0.601
M65.47 Radial styloid tenosynovitis [de Quervain]-Ankle/foot
0.000 0.399 0.601
M65.46 Radial styloid tenosynovitis [de Quervain]-Lower leg
0.000 0.399 0.601
M65.45 Radial styloid tenosynovitis [de Quervain]-Pelvic/thigh
0.000 0.399 0.601
M65.42 Radial styloid tenosynovitis [de Quervain]-Upper arm
0.000 0.399 0.601
M65.41 Radial styloid tenosynovitis [de Quervain]-Shldr region
0.000 0.399 0.601
M65.40 Radial styloid tenosynovitis [de Quervain] (Multiple sites)
0.000 0.399 0.601
E88.3 Tumour lysis syndrome
0.000 0.400 0.599
E28.3 Primary ovarian failure
0.000 0.401 0.599
I15.8 Other secondary hypertension
0.000 0.404 0.596
I15.2 Hypertension secondary to endocrine disorders
0.000 0.404 0.596
M83 Adult osteomalacia
0.000 0.406 0.594
L58 Radiodermatitis
0.000 0.407 0.593
L57.8 Other skin changes due to chronic exposure to nonionising radiation
0.000 0.407 0.593
M80.8 Other osteoporosis with pathological fracture
0.000 0.408 0.592
I11 Hypertensive heart disease
0.000 0.409 0.591
M33 Dermatopolymyositis
0.000 0.411 0.589
M10 Gout
0.000 0.413 0.587
L95.8 Other vasculitis limited to skin
0.000 0.413 0.587
M91-M94 Chondropathies
0.000 0.414 0.586
M65.91 Synovitis and tenosynovitis, unspecified (Shoulder region)
0.000 0.417 0.583
L12 Pemphigoid
0.000 0.418 0.582
E88.9 Metabolic disorder, unspecified
0.000 0.419 0.581
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.419 0.581
I24.8 Other forms of acute ischaemic heart disease
0.000 0.419 0.581
E24 Cushing's syndrome
0.000 0.419 0.581
E26 Hyperaldosteronism
0.000 0.420 0.580
G56.8 Other mononeuropathies of upper limb
0.000 0.422 0.578
I21.9 Acute myocardial infarction, unspecified
0.000 0.424 0.576
M31.1 Thrombotic microangiopathy
0.000 0.424 0.576

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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