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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs241424
log Bayes Factor = 142.173
Chromosome 6   position 32,804,934  (GRCh37) Explore rs241424 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
E10.9 Without complications
1.000 0.000 0.000
E10.3 With ophthalmic complications
1.000 0.000 0.000
K90.0 Coeliac disease
1.000 0.000 0.000
E05 Thyrotoxicosis [hyperthyroidism]
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
1.000 0.000 0.000
E10-E14 Diabetes mellitus
1.000 0.000 0.000
E00-E07 Disorders of thyroid gland
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
E03 Other hypothyroidism
1.000 0.000 0.000
E11 Non-insulin-dependent diabetes mellitus
1.000 0.000 0.000
E16.2 Hypoglycaemia, unspecified
1.000 0.000 0.000
E05.9 Thyrotoxicosis, unspecified
1.000 0.000 0.000
E05.0 Thyrotoxicosis with diffuse goitre
1.000 0.000 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
1.000 0.000 0.000
E16 Other disorders of pancreatic internal secretion
1.000 0.000 0.000
E14 Unspecified diabetes mellitus
1.000 0.000 0.000
H36.0 Diabetic retinopathy
0.999 0.001 0.000
E11.3 With ophthalmic complications
0.998 0.002 0.000
E10.1 With ketoacidosis
0.997 0.003 0.000
E10.4 With neurological complications
0.997 0.003 0.000
E14.3 With ophthalmic complications
0.996 0.004 0.000
E10.2 With renal complications
0.987 0.013 0.000
E11.2 With renal complications
0.985 0.015 0.000
E14.9 Without complications
0.968 0.032 0.000
E20-E35 Disorders of other endocrine glands
0.961 0.039 0.000
N00-N08 Glomerular diseases
0.945 0.055 0.000
N04 Nephrotic syndrome
0.943 0.057 0.000
N08 Glomerular disorders in diseases classified elsewhere
0.942 0.058 0.000
N08.3 Glomerular disorders in diabetes mellitus
0.942 0.058 0.000
N04.9 Unspecified
0.939 0.061 0.000
E27 Other disorders of adrenal gland
0.935 0.065 0.000
N05 Unspecified nephritic syndrome
0.933 0.067 0.000
E27.1 Primary adrenocortical insufficiency
0.921 0.079 0.000
E22 Hyperfunction of pituitary gland
0.913 0.087 0.000
E10.0 With coma
0.910 0.090 0.000
E06 Thyroiditis
0.905 0.095 0.000
N05.9 Unspecified
0.900 0.100 0.000
E10.6 With other specified complications
0.892 0.108 0.000
E11.9 Without complications
0.890 0.110 0.000
E11.6 With other specified complications
0.877 0.123 0.000
E10.5 With peripheral circulatory complications
0.874 0.126 0.000
E06.3 Autoimmune thyroiditis
0.860 0.140 0.000
E22.1 Hyperprolactinaemia
0.849 0.151 0.000
E10.8 With unspecified complications
0.846 0.154 0.000
E03.8 Other specified hypothyroidism
0.837 0.163 0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.832 0.168 0.000
N05.1 Focal and segmental glomerular lesions
0.823 0.177 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.822 0.178 0.000
E03.0 Congenital hypothyroidism with diffuse goitre
0.819 0.181 0.000
E14.8 With unspecified complications
0.814 0.186 0.000
E14.6 With other specified complications
0.810 0.190 0.000
N05.2 Diffuse membranous glomerulonephritis
0.809 0.191 0.000
N04.1 Focal and segmental glomerular lesions
0.800 0.200 0.000
E10.7 With multiple complications
0.795 0.205 0.000
E50-E64 Other nutritional deficiencies
0.766 0.234 0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.763 0.237 0.000
E27.3 Drug-induced adrenocortical insufficiency
0.762 0.238 0.000
E14.5 With peripheral circulatory complications
0.757 0.243 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.749 0.251 0.000
E16.1 Other hypoglycaemia
0.738 0.262 0.000
N05.5 Diffuse mesangiocapillary glomerulonephritis
0.733 0.267 0.000
N04.2 Diffuse membranous glomerulonephritis
0.733 0.267 0.000
E13 Other specified diabetes mellitus
0.732 0.267 0.000
E61 Deficiency of other nutrient elements
0.732 0.268 0.000
K90 Intestinal malabsorption
0.732 0.268 0.000
E11.8 With unspecified complications
0.730 0.270 0.000
E11.5 With peripheral circulatory complications
0.723 0.277 0.000
H36 Retinal disorders in diseases classified elsewhere
0.718 0.282 0.000
E05.5 Thyroid crisis or storm
0.717 0.283 0.000
E05.4 Thyrotoxicosis factitia
0.717 0.283 0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.717 0.283 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.717 0.283 0.000
E00 Congenital iodine-deficiency syndrome
0.717 0.283 0.000
E12 Malnutrition-related diabetes mellitus
0.717 0.283 0.000
E03.5 Myxoedema coma
0.717 0.283 0.000
E03.4 Atrophy of thyroid (acquired)
0.717 0.283 0.000
E03.3 Postinfectious hypothyroidism
0.717 0.283 0.000
N04.8 Other
0.717 0.283 0.000
E11.7 With multiple complications
0.717 0.283 0.000
E15 Nondiabetic hypoglycaemic coma
0.717 0.283 0.000
E16.9 Disorder of pancreatic internal secretion, unspecified
0.717 0.283 0.000
E16.8 Other specified disorders of pancreatic internal secretion
0.717 0.283 0.000
E16.4 Abnormal secretion of gastrin
0.717 0.283 0.000
E16.3 Increased secretion of glucagon
0.717 0.283 0.000
E14.7 With multiple complications
0.717 0.283 0.000
E14.0 With coma
0.717 0.283 0.000
N00 Acute nephritic syndrome
0.714 0.286 0.000
N05.8 Other
0.713 0.286 0.000
E61.1 Iron deficiency
0.713 0.287 0.000
E24 Cushing's syndrome
0.711 0.289 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.711 0.289 0.000
E11.0 With coma
0.708 0.292 0.000
E31 Polyglandular dysfunction
0.706 0.293 0.000
N04.0 Minor glomerular abnormality
0.702 0.298 0.000
E14.2 Withrenal complications
0.697 0.303 0.000
E27.8 Other specified disorders of adrenal gland
0.697 0.303 0.000
E20 Hypoparathyroidism
0.695 0.305 0.000
E14.4 With neurological complications
0.694 0.306 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.689 0.311 0.000
E32 Diseases of thymus
0.689 0.311 0.000
E30 Disorders of puberty, not elsewhere classified
0.689 0.311 0.000
N08.5 Glomerular disorders in systemic connective tissue disorders
0.685 0.315 0.000
E27.9 Disorder of adrenal gland, unspecified
0.679 0.321 0.000
N07 Hereditary nephropathy, not elsewhere classified
0.677 0.323 0.000
N06 Isolated proteinuria with specified morphological lesion
0.677 0.323 0.000
N01 Rapidly progressive nephritic syndrome
0.677 0.323 0.000
N04.7 Diffuse crescentic glomerulonephritis
0.676 0.323 0.000
N04.6 Dense deposit disease
0.676 0.323 0.000
N04.5 Diffuse mesangiocapillary glomerulonephritis
0.676 0.323 0.000
N04.4 Diffuse endocapillary proliferative glomerulonephritis
0.676 0.323 0.000
N04.3 Diffuse mesangial proliferative glomerulonephritis
0.676 0.323 0.000
N08.8 Glomerular disorders in other diseases classified elsewhere
0.676 0.324 0.000
N08.2 Glomerular disorders in blood diseases and disorders involving the immune mechanism
0.676 0.324 0.000
N08.1 Glomerular disorders in neoplastic diseases
0.676 0.324 0.000
N08.0 Glomerular disorders in infectious and parasitic diseases classified elsewhere
0.676 0.324 0.000
E28 Ovarian dysfunction
0.674 0.326 0.000
E27.5 Adrenomedullary hyperfunction
0.671 0.329 0.000
E27.0 Other adrenocortical overactivity
0.671 0.329 0.000
N05.6 Dense deposit disease
0.669 0.331 0.000
N05.4 Diffuse endocapillary proliferative glomerulonephritis
0.669 0.331 0.000
N05.0 Minor glomerular abnormality
0.669 0.331 0.000
E05.8 Other thyrotoxicosis
0.668 0.332 0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.660 0.340 0.000
E27.2 Addisonian crisis
0.659 0.341 0.000
E22.9 Hyperfunction of pituitary gland, unspecified
0.655 0.345 0.000
E22.8 Other hyperfunction of pituitary gland
0.655 0.345 0.000
E25 Adrenogenital disorders
0.654 0.346 0.000
E06.4 Drug-induced thyroiditis
0.649 0.351 0.000
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.649 0.351 0.000
E06.0 Acute thyroiditis
0.649 0.351 0.000
N08.4 Glomerular disorders in other endocrine, nutritional and metabolic diseases
0.647 0.353 0.000
E06.1 Subacute thyroiditis
0.644 0.356 0.000
E34 Other endocrine disorders
0.636 0.364 0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.634 0.366 0.000
E03.1 Congenital hypothyroidism without goitre
0.629 0.371 0.000
E40-E46 Malnutrition
0.621 0.379 0.000
N02 Recurrent and persistent haematuria
0.617 0.383 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.615 0.384 0.000
E13.3 With ophthalmic complications
0.601 0.398 0.000
N05.7 Diffuse crescentic glomerulonephritis
0.597 0.403 0.000
E06.5 Other chronic thyroiditis
0.596 0.403 0.000
E11.1 With ketoacidosis
0.592 0.408 0.000
E06.9 Thyroiditis, unspecified
0.589 0.411 0.000
E14.1 With ketoacidosis
0.587 0.412 0.000
E28.3 Primary ovarian failure
0.563 0.437 0.000
E24.8 Other Cushing's syndrome
0.562 0.438 0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.555 0.444 0.000
E64 Sequelae of malnutrition and other nutritional deficiencies
0.549 0.450 0.000
E63 Other nutritional deficiencies
0.549 0.450 0.000
E50 Vitamin A deficiency
0.549 0.450 0.000
E60 Dietary zinc deficiency
0.549 0.450 0.000
E59 Dietary selenium deficiency
0.549 0.450 0.000
E54 Ascorbic acid deficiency
0.549 0.450 0.000
E52 Niacin deficiency [pellagra]
0.549 0.450 0.000
N00.9 Unspecified
0.549 0.451 0.000
K90.8 Other intestinal malabsorption
0.549 0.451 0.000
E24.2 Drug-induced Cushing's syndrome
0.547 0.453 0.000
E29 Testicular dysfunction
0.546 0.454 0.000
E24.0 Pituitary-dependent Cushing's disease
0.542 0.457 0.000
E11.4 With neurological complications
0.539 0.461 0.000
K90.9 Intestinal malabsorption, unspecified
0.538 0.462 0.000
E21.2 Other hyperparathyroidism
0.529 0.471 0.000
E13.8 With unspecified complications
0.525 0.475 0.000
E13.7 With multiple complications
0.525 0.475 0.000
E13.6 With other specified complications
0.525 0.475 0.000
E13.5 With peripheral circulatory complications
0.525 0.475 0.000
E13.4 With neurological complications
0.525 0.475 0.000
E13.2 With renal complications
0.525 0.475 0.000
E13.1 With ketoacidosis
0.525 0.475 0.000
E13.0 With coma
0.525 0.475 0.000
E61.9 Deficiency of nutrient element, unspecified
0.525 0.475 0.000
E61.8 Deficiency of other specified nutrient elements
0.525 0.475 0.000
E61.7 Deficiency of multiple nutrient elements
0.525 0.475 0.000
E61.6 Vanadium deficiency
0.525 0.475 0.000
E61.5 Molybdenum deficiency
0.525 0.475 0.000
E61.4 Chromium deficiency
0.525 0.475 0.000
E61.3 Manganese deficiency
0.525 0.475 0.000
E61.0 Copper deficiency
0.525 0.475 0.000
K90.3 Pancreatic steatorrhoea
0.525 0.475 0.000
K90.2 Blind loop syndrome, not elsewhere classified
0.525 0.475 0.000
K90.1 Tropical sprue
0.525 0.475 0.000
E31.0 Autoimmune polyglandular failure
0.524 0.476 0.000
E21.4 Other specified disorders of parathyroid gland
0.524 0.476 0.000
E51 Thiamine deficiency
0.522 0.478 0.000
H30-H36 Disorders of choroid and retina
0.517 0.483 0.000
H36.8 Other retinal disorders in diseases classified elsewhere
0.515 0.485 0.000
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.514 0.486 0.000
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.514 0.486 0.000
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.514 0.486 0.000
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.514 0.486 0.000
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.514 0.486 0.000
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.514 0.486 0.000
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.514 0.486 0.000
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.514 0.486 0.000
E12.9 Without complications
0.514 0.486 0.000
E12.8 With unspecified complications
0.514 0.486 0.000
E12.7 With multiple complications
0.514 0.486 0.000
E12.6 With other specified complications
0.514 0.486 0.000
E12.5 With peripheral circulatory complications
0.514 0.486 0.000
E12.4 With neurological complications
0.514 0.486 0.000
E12.3 With ophthalmic complications
0.514 0.486 0.000
E12.2 With renal complications
0.514 0.486 0.000
E12.1 With ketoacidosis
0.514 0.486 0.000
E12.0 With coma
0.514 0.486 0.000
N02.2 Diffuse membranous glomerulonephritis
0.514 0.486 0.000
N00.8 Other
0.512 0.488 0.000
N00.7 Diffuse crescentic glomerulonephritis
0.512 0.488 0.000
N00.6 Dense deposit disease
0.512 0.488 0.000
N00.5 Diffuse mesangiocapillary glomerulonephritis
0.512 0.488 0.000
N00.4 Diffuse endocapillary proliferative glomerulonephritis
0.512 0.488 0.000
N00.3 Diffuse mesangial proliferative glomerulonephritis
0.512 0.488 0.000
N00.2 Diffuse membranous glomerulonephritis
0.512 0.488 0.000
N00.1 Focal and segmental glomerular lesions
0.512 0.488 0.000
N00.0 Minor glomerular abnormality
0.512 0.488 0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.509 0.490 0.000
E24.3 Ectopic ACTH syndrome
0.509 0.490 0.000
E24.1 Nelson's syndrome
0.509 0.490 0.000
E31.9 Polyglandular dysfunction, unspecified
0.506 0.493 0.000
E31.8 Other polyglandular dysfunction
0.506 0.493 0.000
E31.1 Polyglandular hyperfunction
0.506 0.493 0.000
E56 Other vitamin deficiencies
0.504 0.495 0.000
E20.9 Hypoparathyroidism, unspecified
0.504 0.495 0.000
E20.8 Other hypoparathyroidism
0.498 0.502 0.000
E20.1 Pseudohypoparathyroidism
0.498 0.502 0.000
E20.0 Idiopathic hypoparathyroidism
0.498 0.502 0.000
E21.5 Disorder of parathyroid gland, unspecified
0.496 0.504 0.000
E30.9 Disorder of puberty, unspecified
0.494 0.506 0.000
E30.8 Other disorders of puberty
0.494 0.506 0.000
E30.1 Precocious puberty
0.494 0.506 0.000
E30.0 Delayed puberty
0.494 0.506 0.000
E32.9 Disease of thymus, unspecified
0.494 0.506 0.000
E32.8 Other diseases of thymus
0.494 0.506 0.000
E32.1 Abscess of thymus
0.494 0.506 0.000
E32.0 Persistent hyperplasia of thymus
0.494 0.506 0.000
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.494 0.506 0.000
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.494 0.506 0.000
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.494 0.506 0.000
N01.9 Unspecified
0.486 0.514 0.000
N01.8 Other
0.486 0.514 0.000
N01.7 Diffuse crescentic glomerulonephritis
0.486 0.514 0.000
N01.6 Dense deposit disease
0.486 0.514 0.000
N01.5 Diffuse mesangiocapillary glomerulonephritis
0.486 0.514 0.000
N01.4 Diffuse endocapillary proliferative glomerulonephritis
0.486 0.514 0.000
N01.3 Diffuse mesangial proliferative glomerulonephritis
0.486 0.514 0.000
N01.2 Diffuse membranous glomerulonephritis
0.486 0.514 0.000
N01.1 Focal and segmental glomerular lesions
0.486 0.514 0.000
N01.0 Minor glomerular abnormality
0.486 0.514 0.000
N06.9 Unspecified
0.486 0.514 0.000
N06.8 Other
0.486 0.514 0.000
N06.7 Diffuse crescentic glomerulonephritis
0.486 0.514 0.000
N06.6 Dense deposit disease
0.486 0.514 0.000
N06.5 Diffuse mesangiocapillary glomerulonephritis
0.486 0.514 0.000
N06.4 Diffuse endocapillary proliferative glomerulonephritis
0.486 0.514 0.000
N06.3 Diffuse mesangial proliferative glomerulonephritis
0.486 0.514 0.000
N06.2 Diffuse membranous glomerulonephritis
0.486 0.514 0.000
N06.1 Focal and segmental glomerular lesions
0.486 0.514 0.000
N06.0 Minor glomerular abnormality
0.486 0.514 0.000
N07.9 Unspecified
0.486 0.514 0.000
N07.8 Other
0.486 0.514 0.000
N07.7 Diffuse crescentic glomerulonephritis
0.486 0.514 0.000
N07.6 Dense deposit disease
0.486 0.514 0.000
N07.5 Diffuse mesangiocapillary glomerulonephritis
0.486 0.514 0.000
N07.4 Diffuse endocapillary proliferative glomerulonephritis
0.486 0.514 0.000
N07.3 Diffuse mesangial proliferative glomerulonephritis
0.486 0.514 0.000
N07.2 Diffuse membranous glomerulonephritis
0.486 0.514 0.000
N07.1 Focal and segmental glomerular lesions
0.486 0.514 0.000
N07.0 Minor glomerular abnormality
0.486 0.514 0.000
E58 Dietary calcium deficiency
0.486 0.514 0.000
E22.0 Acromegaly and pituitary gigantism
0.484 0.515 0.000
E28.9 Ovarian dysfunction, unspecified
0.483 0.517 0.000
E28.8 Other ovarian dysfunction
0.483 0.517 0.000
E28.1 Androgen excess
0.483 0.517 0.000
E28.0 Oestrogen excess
0.483 0.517 0.000
E61.2 Magnesium deficiency
0.480 0.520 0.000
N05.3 Diffuse mesangial proliferative glomerulonephritis
0.474 0.526 0.001
E25.9 Adrenogenital disorder, unspecified
0.469 0.531 0.000
E25.8 Other adrenogenital disorders
0.469 0.531 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.468 0.532 0.000
E26 Hyperaldosteronism
0.467 0.533 0.001
N03 Chronic nephritic syndrome
0.458 0.542 0.000
H33 Retinal detachments and breaks
0.458 0.542 0.000
E07 Other disorders of thyroid
0.457 0.543 0.000
N02.3 Diffuse mesangial proliferative glomerulonephritis
0.456 0.544 0.000
E34.5 Androgen resistance syndrome
0.456 0.544 0.000
E34.4 Constitutional tall stature
0.456 0.544 0.000
E34.2 Ectopic hormone secretion, not elsewhere classified
0.456 0.544 0.000
E34.1 Other hypersecretion of intestinal hormones
0.456 0.544 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.455 0.545 0.000
D60-D64 Aplastic and other anaemias
0.454 0.546 0.000
D64.9 Anaemia, unspecified
0.454 0.546 0.000
D64 Other anaemias
0.453 0.547 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.453 0.547 0.000
E34.3 Short stature, not elsewhere classified
0.451 0.549 0.000
Q80-Q89 Other congenital malformations
0.451 0.549 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.449 0.551 0.000
E34.9 Endocrine disorder, unspecified
0.448 0.552 0.000
E21.3 Hyperparathyroidism, unspecified
0.446 0.554 0.000
E44 Protein-energy malnutrition of moderate and mild degree
0.445 0.554 0.000
E45 Retarded development following protein-energy malnutrition
0.445 0.554 0.000
E43 Unspecified severe protein-energy malnutrition
0.445 0.554 0.000
E42 Marasmic kwashiorkor
0.445 0.554 0.000
E41 Nutritional marasmus
0.445 0.554 0.000
E40 Kwashiorkor
0.445 0.554 0.000
E55 Vitamin D deficiency
0.444 0.556 0.000
E34.0 Carcinoid syndrome
0.443 0.557 0.000
N02.7 Diffuse crescentic glomerulonephritis
0.442 0.558 0.000
N02.6 Dense deposit disease
0.442 0.558 0.000
N02.5 Diffuse mesangiocapillary glomerulonephritis
0.442 0.558 0.000
N02.4 Diffuse endocapillary proliferative glomerulonephritis
0.442 0.558 0.000
N02.1 Focal and segmental glomerular lesions
0.442 0.558 0.000
N02.0 Minor glomerular abnormality
0.442 0.558 0.000
D66 Hereditary factor VIII deficiency
0.441 0.559 0.000
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.434 0.566 0.000
Q85 Phakomatoses, not elsewhere classified
0.434 0.566 0.000
D68 Other coagulation defects
0.433 0.567 0.000
E34.8 Other specified endocrine disorders
0.433 0.567 0.000
D68.2 Hereditary deficiency of other clotting factors
0.432 0.568 0.000
Q50-Q56 Congenital malformations of genital organs
0.431 0.569 0.000
N02.8 Other
0.430 0.570 0.000
E13.9 Without complications
0.429 0.571 0.000
Q44 Congenital malformations of gallbladder, bile ducts and liver
0.427 0.573 0.000
D61 Other aplastic anaemias
0.422 0.578 0.000
H33.5 Other retinal detachments
0.415 0.585 0.000
Q60-Q64 Congenital malformations of the urinary system
0.415 0.585 0.000
H31 Other disorders of choroid
0.415 0.585 0.000
Q85.0 Neurofibromatosis (nonmalignant)
0.407 0.593 0.000
Q44.6 Cystic disease of liver
0.407 0.593 0.000
H33.4 Traction detachment of retina
0.406 0.594 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.404 0.596 0.000
D61.9 Aplastic anaemia, unspecified
0.396 0.604 0.000
E65-E68 Obesity and other hyperalimentation
0.395 0.605 0.000
E50.9 Vitamin A deficiency, unspecified
0.394 0.606 0.000
E50.8 Other manifestations of vitamin A deficiency
0.394 0.606 0.000
E50.7 Other ocular manifestations of vitamin A deficiency
0.394 0.606 0.000
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.394 0.606 0.000
E50.5 Vitamin A deficiency with night blindness
0.394 0.606 0.000
E50.4 Vitamin A deficiency with keratomalacia
0.394 0.606 0.000
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.394 0.606 0.000
E50.2 Vitamin A deficiency with corneal xerosis
0.394 0.606 0.000
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.394 0.606 0.000
E50.0 Vitamin A deficiency with conjunctival xerosis
0.394 0.606 0.000
E63.9 Nutritional deficiency, unspecified
0.394 0.606 0.000
E63.8 Other specified nutritional deficiencies
0.394 0.606 0.000
E63.1 Imbalance of constituents of food intake
0.394 0.606 0.000
E63.0 Essential fatty acid [EFA] deficiency
0.394 0.606 0.000
E64.9 Sequelae of unspecified nutritional deficiency
0.394 0.606 0.000
E64.8 Sequelae of other nutritional deficiencies
0.394 0.606 0.000
E64.3 Sequelae of rickets
0.394 0.606 0.000
E64.2 Sequelae of vitamin C deficiency
0.394 0.606 0.000
E64.1 Sequelae of vitamin A deficiency
0.394 0.606 0.000
E64.0 Sequelae of protein-energy malnutrition
0.394 0.606 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.393 0.607 0.000
Q54 Hypospadias
0.392 0.608 0.000
E29.9 Testicular dysfunction, unspecified
0.391 0.608 0.000
E29.8 Other testicular dysfunction
0.391 0.608 0.000
E29.0 Testicular hyperfunction
0.391 0.608 0.000
Q51 Congenital malformations of uterus and cervix
0.391 0.609 0.000
Chapter VII Diseases of the eye and adnexa
0.390 0.610 0.000
E23 Hypofunction and other disorders of pituitary gland
0.388 0.612 0.000
Q38 Other congenital malformations of tongue, mouth and pharynx
0.385 0.615 0.000
Q61 Cystic kidney disease
0.384 0.616 0.000
H33.0 Retinal detachment with retinal break
0.384 0.616 0.000
H30 Chorioretinal inflammation
0.383 0.616 0.000
Q00-Q07 Congenital malformations of the nervous system
0.377 0.623 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.376 0.624 0.000
# Top node
0.376 0.624 0.000
E51.9 Thiamine deficiency, unspecified
0.375 0.625 0.000
E51.8 Other manifestations of thiamine deficiency
0.375 0.625 0.000
E51.1 Beriberi
0.375 0.625 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.370 0.629 0.000
D50-D53 Nutritional anaemias
0.370 0.630 0.000
Q61.3 Polycystic kidney, unspecified
0.369 0.631 0.000
H50 Other strabismus
0.369 0.631 0.000
Q39 Congenital malformations of oesophagus
0.365 0.635 0.000
Q85.9 Phakomatosis, unspecified
0.364 0.636 0.000
E56.9 Vitamin deficiency, unspecified
0.362 0.638 0.000
E56.8 Deficiency of other vitamins
0.362 0.638 0.000
E56.0 Deficiency of vitamin E
0.362 0.638 0.000
E53 Deficiency of other B group vitamins
0.361 0.639 0.000
H50.9 Strabismus, unspecified
0.359 0.641 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.358 0.642 0.000
Q51.2 Other doubling of uterus
0.357 0.643 0.000
E24.9 Cushing's syndrome, unspecified
0.356 0.644 0.000
D64.8 Other specified anaemias
0.355 0.645 0.000
N03.1 Focal and segmental glomerular lesions
0.354 0.646 0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.352 0.648 0.000
E46 Unspecified protein-energy malnutrition
0.350 0.650 0.000
Q22 Congenital malformations of pulmonary and tricuspid valves
0.349 0.651 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.349 0.651 0.000
D69 Purpura and other haemorrhagic conditions
0.348 0.652 0.000
D68.8 Other specified coagulation defects
0.348 0.652 0.000
E51.2 Wernicke's encephalopathy
0.347 0.652 0.000
D51 Vitamin B12 deficiency anaemia
0.347 0.653 0.000
Q89 Other congenital malformations, not elsewhere classified
0.347 0.653 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.345 0.655 0.000
Q82 Other congenital malformations of skin
0.341 0.659 0.000
N03.5 Diffuse mesangiocapillary glomerulonephritis
0.340 0.660 0.000
Q87 Other specified congenital malformation syndromes affecting multiple systems
0.339 0.660 0.000
Q28 Other congenital malformations of circulatory system
0.339 0.661 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.338 0.662 0.000
Q44.4 Choledochal cyst
0.337 0.662 0.000
D67 Hereditary factor IX deficiency
0.337 0.662 0.000
H31.8 Other specified disorders of choroid
0.336 0.663 0.000
Q27 Other congenital malformations of peripheral vascular system
0.336 0.664 0.000
Q35-Q37 Cleft lip and cleft palate
0.336 0.664 0.000
E26.8 Other hyperaldosteronism
0.335 0.665 0.001
E26.1 Secondary hyperaldosteronism
0.335 0.665 0.001
Q54.0 Hypospadias, balanic
0.335 0.665 0.000
H33.1 Retinoschisis and retinal cysts
0.334 0.666 0.000
Q85.8 Other phakomatoses, not elsewhere classified
0.333 0.667 0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.331 0.669 0.000
D68.0 Von Willebrand's disease
0.330 0.670 0.000
N03.7 Diffuse crescentic glomerulonephritis
0.329 0.671 0.000
N03.6 Dense deposit disease
0.329 0.671 0.000
N03.4 Diffuse endocapillary proliferative glomerulonephritis
0.329 0.671 0.000
N03.3 Diffuse mesangial proliferative glomerulonephritis
0.329 0.671 0.000
N03.2 Diffuse membranous glomerulonephritis
0.329 0.671 0.000
N03.0 Minor glomerular abnormality
0.329 0.671 0.000
Q54.8 Other hypospadias
0.328 0.671 0.000
H47 Other disorders of optic [2nd] nerve and visual pathways
0.328 0.672 0.000
E07.1 Dyshormogenetic goitre
0.328 0.672 0.000
E07.0 Hypersecretion of calcitonin
0.328 0.672 0.000
Q55 Other congenital malformations of male genital organs
0.325 0.674 0.000
D64.4 Congenital dyserythropoietic anaemia
0.325 0.675 0.000
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.325 0.675 0.000
D64.1 Secondary sideroblastic anaemia due to disease
0.325 0.675 0.000
D64.0 Hereditary sideroblastic anaemia
0.325 0.675 0.000
D68.4 Acquired coagulation factor deficiency
0.325 0.675 0.000
Q86 Congenital malformation syndromes due to known exogenous causes, not elsewhere classified
0.323 0.677 0.000
Q84 Other congenital malformations of integument
0.323 0.677 0.000
Q81 Epidermolysis bullosa
0.323 0.677 0.000
Q80 Congenital ichthyosis
0.323 0.677 0.000
H31.3 Choroidal haemorrhage and rupture
0.323 0.677 0.000
D61.1 Drug-induced aplastic anaemia
0.323 0.677 0.000
Q61.2 Polycystic kidney, adult type
0.323 0.677 0.000
Q42 Congenital absence, atresia and stenosis of large intestine
0.322 0.678 0.000
Q41 Congenital absence, atresia and stenosis of small intestine
0.322 0.678 0.000
D69.3 Idiopathic thrombocytopenic purpura
0.321 0.679 0.000
D64.3 Other sideroblastic anaemias
0.320 0.680 0.000
E28.2 Polycystic ovarian syndrome
0.320 0.680 0.000
E44.1 Mild protein-energy malnutrition
0.319 0.680 0.000
E44.0 Moderate protein-energy malnutrition
0.319 0.680 0.000
H50.0 Convergent concomitant strabismus
0.319 0.681 0.000
E55.0 Rickets, active
0.318 0.682 0.000
E56.1 Deficiency of vitamin K
0.317 0.683 0.000
D80-D89 Certain disorders involving the immune mechanism
0.316 0.684 0.000
Q61.9 Cystic kidney disease, unspecified
0.315 0.685 0.000
Q54.9 Hypospadias, unspecified
0.315 0.685 0.000
Q52 Other congenital malformations of female genitalia
0.314 0.686 0.000
Q44.7 Other congenital malformations of liver
0.314 0.686 0.000
H43-H45 Disorders of vitreous body and globe
0.314 0.686 0.000
N03.8 Other
0.313 0.686 0.000
E21.0 Primary hyperparathyroidism
0.313 0.687 0.000
Q38.7 Pharyngeal pouch
0.313 0.687 0.000
Q85.1 Tuberous sclerosis
0.311 0.689 0.000
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.310 0.690 0.000
Q51.8 Other congenital malformations of uterus and cervix
0.309 0.690 0.000
Q56 Indeterminate sex and pseudohermaphroditism
0.309 0.691 0.000
Q24 Other congenital malformations of heart
0.307 0.693 0.000
Q44.3 Congenital stenosis and stricture of bile ducts
0.307 0.693 0.000
Q44.2 Atresia of bile ducts
0.307 0.693 0.000
Q44.1 Other congenital malformations of gallbladder
0.307 0.693 0.000
Q44.0 Agenesis, aplasia and hypoplasia of gallbladder
0.307 0.693 0.000
D68.1 Hereditary factor XI deficiency
0.307 0.693 0.000
E26.9 Hyperaldosteronism, unspecified
0.306 0.694 0.001
Q43 Other congenital malformations of intestine
0.306 0.694 0.000
Q38.1 Ankyloglossia
0.306 0.694 0.000
D53 Other nutritional anaemias
0.305 0.694 0.000
Q40 Other congenital malformations of upper alimentary tract
0.304 0.696 0.000
Q63 Other congenital malformations of kidney
0.304 0.696 0.000
Q83 Congenital malformations of breast
0.303 0.697 0.000
D61.8 Other specified aplastic anaemias
0.302 0.697 0.000
D61.3 Idiopathic aplastic anaemia
0.302 0.697 0.000
D61.2 Aplastic anaemia due to other external agents
0.302 0.697 0.000
Q99 Other chromosome abnormalities, not elsewhere classified
0.301 0.699 0.000
H47.1 Papilloedema, unspecified
0.301 0.699 0.000
E23.7 Disorder of pituitary gland, unspecified
0.300 0.700 0.000
Q62 Congenital obstructive defects of renal pelvis and congenital malformations of ureter
0.300 0.700 0.000
Q07 Other congenital malformations of nervous system
0.300 0.700 0.000
Q51.1 Doubling of uterus with doubling of cervix and vagina
0.298 0.701 0.000
H31.4 Choroidal detachment
0.298 0.702 0.000
H31.2 Hereditary choroidal dystrophy
0.298 0.702 0.000
H31.1 Choroidal degeneration
0.297 0.703 0.000
D61.0 Constitutional aplastic anaemia
0.295 0.704 0.000
Q44.5 Other congenital malformations of bile ducts
0.295 0.705 0.000
Q06 Other congenital malformations of spinal cord
0.294 0.706 0.000
Q38.5 Congenital malformations of palate, not elsewhere classified
0.294 0.706 0.000
H43 Disorders of vitreous body
0.292 0.708 0.000
Q27.3 Peripheral arteriovenous malformation
0.292 0.708 0.000
H31.0 Chorioretinal scars
0.292 0.708 0.000
Q51.4 Unicornate uterus
0.290 0.710 0.000
Q20 Congenital malformations of cardiac chambers and connexions
0.290 0.710 0.000
Q82.8 Other specified congenital malformations of skin
0.289 0.711 0.000
Q39.9 Congenital malformation of oesophagus, unspecified
0.289 0.711 0.000
H30.9 Chorioretinal inflammation, unspecified
0.288 0.712 0.000
Q22.1 Congenital pulmonary valve stenosis
0.287 0.713 0.000
Q26 Congenital malformations of great veins
0.286 0.714 0.000
Q22.5 Ebstein's anomaly
0.286 0.714 0.000
D63 Anaemia in chronic diseases classified elsewhere
0.286 0.714 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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