TreeWAS – Variant ID: rs2499

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E83.1 Disorders of iron metabolism	1.000	0.000	0.000
L40.9 Psoriasis, unspecified	0.000	0.013	0.987
L40 Psoriasis	0.001	0.018	0.982
E83 Disorders of mineral metabolism	0.979	0.021	0.000
L40.5 Arthropathic psoriasis	0.000	0.023	0.977
E70-E90 Metabolic disorders	0.975	0.025	0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.972	0.028	0.000
E89.0 Postprocedural hypothyroidism	0.961	0.039	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.953	0.047	0.000
E00-E07 Disorders of thyroid gland	0.947	0.053	0.000
G35 Multiple sclerosis	0.945	0.055	0.000
I83.9 Varicose veins of lower extremities without ulcer or inflammation	0.944	0.056	0.000
E03 Other hypothyroidism	0.908	0.092	0.000
E89.2 Postprocedural hypoparathyroidism	0.907	0.093	0.000
E04 Other non-toxic goitre	0.897	0.103	0.000
E03.9 Hypothyroidism, unspecified	0.893	0.107	0.000
E80 Disorders of porphyrin and bilirubin metabolism	0.892	0.108	0.000
E04.2 Non-toxic multinodular goitre	0.874	0.126	0.000
L03.1 Cellulitis of other parts of limb	0.868	0.132	0.000
L40.0 Psoriasis vulgaris	0.000	0.156	0.844
I83 Varicose veins of lower extremities	0.831	0.169	0.000
G35-G37 Demyelinating diseases of the central nervous system	0.818	0.182	0.000
E40-E46 Malnutrition	0.803	0.197	0.000
E06 Thyroiditis	0.791	0.209	0.000
E89.6 Postprocedural adrenocortical(-medullary) hypofunction	0.786	0.214	0.000
E05 Thyrotoxicosis [hyperthyroidism]	0.767	0.233	0.000
E89.4 Postprocedural ovarian failure	0.767	0.233	0.000
E80.1 Porphyria cutanea tarda	0.764	0.235	0.000
E73 Lactose intolerance	0.761	0.239	0.000
E84 Cystic fibrosis	0.760	0.240	0.000
L03 Cellulitis	0.759	0.241	0.000
E80.4 Gilbert's syndrome	0.757	0.243	0.000
Chapter VI Diseases of the nervous system	0.756	0.244	0.000
# Top node	0.752	0.248	0.000
Chapter XII Diseases of the skin and subcutaneous tissue	0.750	0.250	0.000
L00-L08 Infections of the skin and subcutaneous tissue	0.746	0.254	0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified	0.743	0.257	0.000
Chapter IX Diseases of the circulatory system	0.741	0.259	0.000
L40.8 Other psoriasis	0.001	0.270	0.730
Chapter XX External causes of morbidity and mortality	0.729	0.271	0.000
E83.3 Disorders of phosphorus metabolism	0.719	0.281	0.000
E06.3 Autoimmune thyroiditis	0.717	0.283	0.000
E50-E64 Other nutritional deficiencies	0.716	0.284	0.000
Chapter V Mental and behavioural disorders	0.708	0.292	0.000
L40.4 Guttate psoriasis	0.001	0.296	0.704
L40.3 Pustulosis palmaris et plantaris	0.001	0.296	0.704
L40.2 Acrodermatitis continua	0.001	0.296	0.704
L40.1 Generalised pustular psoriasis	0.001	0.296	0.704
E83.9 Disorder of mineral metabolism, unspecified	0.702	0.298	0.000
E83.8 Other disorders of mineral metabolism	0.702	0.298	0.000
E83.2 Disorders of zinc metabolism	0.702	0.298	0.000
E83.0 Disorders of copper metabolism	0.702	0.298	0.000
E04.0 Non-toxic diffuse goitre	0.701	0.299	0.000
E65-E68 Obesity and other hyperalimentation	0.701	0.299	0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.700	0.300	0.000
L20-L30 Dermatitis and eczema	0.700	0.300	0.000
V40-V49 Car occupant injured in transport accident	0.700	0.300	0.000
E79 Disorders of purine and pyrimidine metabolism	0.699	0.301	0.000
E77 Disorders of glycoprotein metabolism	0.699	0.301	0.000
E76 Disorders of glycosaminoglycan metabolism	0.699	0.301	0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.699	0.301	0.000
E72 Other disorders of amino-acid metabolism	0.699	0.301	0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.699	0.301	0.000
E70 Disorders of aromatic amino-acid metabolism	0.699	0.301	0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.699	0.301	0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified	0.697	0.303	0.000
E89.8 Other postprocedural endocrine and metabolic disorders	0.697	0.303	0.000
E89.5 Postprocedural testicular hypofunction	0.697	0.303	0.000
E89.1 Postprocedural hypoinsulinaemia	0.697	0.303	0.000
E46 Unspecified protein-energy malnutrition	0.695	0.305	0.000
I60-I69 Cerebrovascular diseases	0.691	0.309	0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use	0.690	0.310	0.000
L40-L45 Papulosquamous disorders	0.545	0.317	0.138
Y45 Analgesics, antipyretics and anti-inflammatory drugs	0.683	0.317	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.679	0.321	0.000
E74 Other disorders of carbohydrate metabolism	0.679	0.321	0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.679	0.321	0.000
E00 Congenital iodine-deficiency syndrome	0.679	0.321	0.000
E02 Subclinical iodine-deficiency hypothyroidism	0.679	0.321	0.000
F10 Mental and behavioural disorders due to use of alcohol	0.678	0.322	0.000
F10.1 Harmful use	0.677	0.323	0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction	0.677	0.323	0.000
I69 Sequelae of cerebrovascular disease	0.672	0.328	0.000
I83.0 Varicose veins of lower extremities with ulcer	0.671	0.329	0.000
E80.6 Other disorders of bilirubin metabolism	0.668	0.332	0.000
L60-L75 Disorders of skin appendages	0.666	0.334	0.000
I70-I79 Diseases of arteries, arterioles and capillaries	0.666	0.334	0.000
L04 Acute lymphadenitis	0.665	0.335	0.000
G20-G26 Extrapyramidal and movement disorders	0.664	0.336	0.000
Q20-Q28 Congenital malformations of the circulatory system	0.657	0.343	0.000
V49 Car occupant injured in other and unspecified transport accidents	0.655	0.345	0.000
L29 Pruritus	0.654	0.346	0.000
E03.5 Myxoedema coma	0.651	0.349	0.000
E03.4 Atrophy of thyroid (acquired)	0.651	0.349	0.000
E03.3 Postinfectious hypothyroidism	0.651	0.349	0.000
E03.1 Congenital hypothyroidism without goitre	0.651	0.349	0.000
E03.0 Congenital hypothyroidism with diffuse goitre	0.651	0.349	0.000
E80.2 Other porphyria	0.649	0.351	0.000
Y44 Agents primarily affecting blood constituents	0.649	0.351	0.000
L71 Rosacea	0.647	0.353	0.000
E04.9 Non-toxic goitre, unspecified	0.646	0.354	0.000
E20-E35 Disorders of other endocrine glands	0.644	0.356	0.000
I95-I99 Other and unspecified disorders of the circulatory system	0.644	0.356	0.000
E04.8 Other specified non-toxic goitre	0.643	0.357	0.000
E80.7 Disorder of bilirubin metabolism, unspecified	0.640	0.360	0.000
E80.5 Crigler-Najjar syndrome	0.640	0.360	0.000
E80.3 Defects of catalase and peroxydase	0.640	0.360	0.000
E80.0 Hereditary erythropoietic porphyria	0.640	0.360	0.000
E05.9 Thyrotoxicosis, unspecified	0.638	0.362	0.000
G25 Other extrapyramidal and movement disorders	0.636	0.364	0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors	0.635	0.365	0.000
E88 Other metabolic disorders	0.634	0.366	0.000
E65 Localised adiposity	0.633	0.367	0.000
Y45.0 Opioids and related analgesics	0.628	0.372	0.000
X40-X49 Accidental poisoning by and exposure to noxious substances	0.623	0.377	0.000
I65.2 Occlusion and stenosis of carotid artery	0.620	0.380	0.000
E53 Deficiency of other B group vitamins	0.619	0.381	0.000
I83.2 Varicose veins of lower extremities with both ulcer and inflammation	0.619	0.381	0.000
I69.3 Sequelae of cerebral infarction	0.619	0.381	0.000
G30-G32 Other degenerative diseases of the nervous system	0.615	0.385	0.000
Y45.2 Propionic acid derivatives	0.615	0.385	0.000
I65.0 Occlusion and stenosis of vertebral artery	0.612	0.388	0.000
I88 Nonspecific lymphadenitis	0.610	0.390	0.000
E73.9 Lactose intolerance, unspecified	0.608	0.392	0.000
E84.9 Cystic fibrosis, unspecified	0.606	0.394	0.000
F60-F69 Disorders of adult personality and behaviour	0.606	0.394	0.000
V43 Car occupant injured in collision with car, pick-up truck or van	0.604	0.396	0.000
V20-V29 Motorcycle rider injured in transport accident	0.601	0.399	0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use	0.601	0.399	0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.600	0.399	0.000
G25.8 Other specified extrapyramidal and movement disorders	0.600	0.400	0.000
F10.5 Psychotic disorder	0.599	0.401	0.000
I99 Other and unspecified disorders of circulatory system	0.598	0.402	0.000
L21 Seborrhoeic dermatitis	0.597	0.403	0.000
E83.5 Disorders of calcium metabolism	0.596	0.404	0.000
L71.9 Rosacea, unspecified	0.595	0.405	0.000
Q25 Congenital malformations of great arteries	0.594	0.406	0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism	0.594	0.406	0.000
Y44.2 Anticoagulants	0.593	0.407	0.000
I85 Oesophageal varices	0.592	0.408	0.000
G00-G09 Inflammatory diseases of the central nervous system	0.591	0.409	0.000
E27 Other disorders of adrenal gland	0.586	0.414	0.000
G36 Other acute disseminated demyelination	0.586	0.414	0.000
W00-W19 Falls	0.586	0.414	0.000
I72 Other aneurysm	0.584	0.416	0.000
Y41 Other systemic anti-infectives and antiparasitics	0.581	0.419	0.000
E05.0 Thyrotoxicosis with diffuse goitre	0.580	0.420	0.000
F00-F09 Organic, including symptomatic, mental disorders	0.579	0.421	0.000
L20 Atopic dermatitis	0.578	0.421	0.000
F11 Mental and behavioural disorders due to use of opioids	0.577	0.422	0.000
I98 Other disorders of circulatory system in diseases classified elsewhere	0.577	0.423	0.000
G80-G83 Cerebral palsy and other paralytic syndromes	0.576	0.424	0.000
E44 Protein-energy malnutrition of moderate and mild degree	0.576	0.424	0.000
E45 Retarded development following protein-energy malnutrition	0.576	0.424	0.000
E43 Unspecified severe protein-energy malnutrition	0.576	0.424	0.000
E42 Marasmic kwashiorkor	0.576	0.424	0.000
E41 Nutritional marasmus	0.576	0.424	0.000
E40 Kwashiorkor	0.576	0.424	0.000
Q80-Q89 Other congenital malformations	0.570	0.430	0.000
V49.4 Driver injured in collision with other and unspecified motor vehicles in traffic accident	0.569	0.431	0.000
I77 Other disorders of arteries and arterioles	0.568	0.432	0.000
E06.5 Other chronic thyroiditis	0.567	0.433	0.000
E06.4 Drug-induced thyroiditis	0.567	0.433	0.000
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.567	0.433	0.000
E06.1 Subacute thyroiditis	0.567	0.433	0.000
E06.0 Acute thyroiditis	0.567	0.433	0.000
Chapter XXII Codes for special purposes	0.567	0.433	0.000
L71.1 Rhinophyma	0.561	0.439	0.000
I70 Atherosclerosis	0.561	0.439	0.000
I69.1 Sequelae of intracerebral haemorrhage	0.561	0.439	0.000
E58 Dietary calcium deficiency	0.559	0.441	0.000
Q23 Congenital malformations of aortic and mitral valves	0.558	0.442	0.000
L04.9 Acute lymphadenitis, unspecified	0.557	0.443	0.000
E34 Other endocrine disorders	0.557	0.443	0.000
X50-X57 Overexertion, travel and privation	0.555	0.445	0.000
L04.1 Acute lymphadenitis of trunk	0.555	0.445	0.000
E53.8 Deficiency of other specified B group vitamins	0.555	0.445	0.000
V49.9 Car occupant [any] injured in unspecified traffic accident	0.555	0.445	0.000
Q24 Other congenital malformations of heart	0.554	0.446	0.000
W75-W84 Other accidental threats to breathing	0.554	0.446	0.000
L29.8 Other pruritus	0.553	0.447	0.000
V48 Car occupant injured in noncollision transport accident	0.552	0.448	0.000
L29.2 Pruritus vulvae	0.552	0.448	0.000
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction	0.551	0.449	0.000
E05.5 Thyroid crisis or storm	0.550	0.450	0.000
E05.4 Thyrotoxicosis factitia	0.550	0.450	0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.550	0.450	0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.550	0.450	0.000
F12 Mental and behavioural disorders due to use of cannabinoids	0.550	0.450	0.000
V01-V09 Pedestrian injured in transport accident	0.549	0.451	0.000
Y48 Anaesthetics and therapeutic gases	0.548	0.452	0.000
E05.8 Other thyrotoxicosis	0.548	0.452	0.000
X60-X84 Intentional self-harm	0.548	0.452	0.000
I65.3 Occlusion and stenosis of multiple and bilateral precerebral arteries	0.547	0.453	0.000
Y45.8 Other analgesics and antipyretics	0.547	0.453	0.000
V80-V89 Other land transport accidents	0.546	0.454	0.000
E73.8 Other lactose intolerance	0.546	0.454	0.000
E73.1 Secondary lactase deficiency	0.546	0.454	0.000
E73.0 Congenital lactase deficiency	0.546	0.454	0.000
E84.8 Cystic fibrosis with other manifestations	0.545	0.455	0.000
E84.1 Cystic fibrosis with intestinal manifestations	0.545	0.455	0.000
E84.0 Cystic fibrosis with pulmonary manifestations	0.545	0.455	0.000
L71.8 Other rosacea	0.545	0.455	0.000
X00-X09 Exposure to smoke, fire and flames	0.543	0.457	0.000
Chapter XVI Certain conditions originating in the perinatal period	0.539	0.460	0.000
V43.9 Unspecified car occupant injured in traffic accident	0.536	0.464	0.000
E85 Amyloidosis	0.536	0.464	0.000
L01 Impetigo	0.535	0.465	0.000
L00 Staphylococcal scalded skin syndrome	0.535	0.465	0.000
I69.2 Sequelae of other nontraumatic intracranial haemorrhage	0.533	0.467	0.000
V49.6 Unspecified car occupant injured in collision with other and unspecified motor vehicles in traffic accident	0.533	0.467	0.000
V70-V79 Bus occupant injured in transport accident	0.531	0.468	0.000
Q28 Other congenital malformations of circulatory system	0.531	0.468	0.000
I00-I02 Acute rheumatic fever	0.531	0.469	0.000
I77.1 Stricture of artery	0.531	0.469	0.000
V28 Motorcycle rider injured in noncollision transport accident	0.530	0.470	0.000
E27.1 Primary adrenocortical insufficiency	0.528	0.472	0.000
L63 Alopecia areata	0.528	0.472	0.000
F80-F89 Disorders of psychological development	0.527	0.473	0.000
L28 Lichen simplex chronicus and prurigo	0.527	0.473	0.000
F10.9 Unspecified mental and behavioural disorder	0.526	0.473	0.000
L29.9 Pruritus, unspecified	0.526	0.474	0.000
F55 Abuse of non-dependence-producing substances	0.525	0.475	0.000
G90-G99 Other disorders of the nervous system	0.525	0.475	0.000
I05-I09 Chronic rheumatic heart diseases	0.524	0.476	0.000
L21.9 Seborrhoeic dermatitis, unspecified	0.524	0.476	0.000
E27.8 Other specified disorders of adrenal gland	0.524	0.476	0.000
Y35-Y36 Legal intervention and operations of war	0.523	0.477	0.000
Y10-Y34 Event of undetermined intent	0.523	0.477	0.000
X85-X99 Assault	0.523	0.477	0.000
X30-X39 Exposure to forces of nature	0.523	0.477	0.000
W65-W74 Accidental drowning and submersion	0.523	0.477	0.000
V98-V99 Other and unspecified transport accidents	0.523	0.477	0.000
V95-V97 Air and space transport accidents	0.523	0.477	0.000
V90-V94 Water transport accidents	0.523	0.477	0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident	0.523	0.477	0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident	0.523	0.477	0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident	0.523	0.477	0.000
I65.1 Occlusion and stenosis of basilar artery	0.523	0.477	0.000
Y45.5 4-Aminophenol derivatives	0.522	0.477	0.000
Y59 Other and unspecified vaccines and biological substances	0.522	0.477	0.000
Q35-Q37 Cleft lip and cleft palate	0.522	0.478	0.000
G06 Intracranial and intraspinal abscess and granuloma	0.522	0.478	0.000
Y47 Sedatives, hypnotics and antianxiety drugs	0.522	0.478	0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.518	0.482	0.000
I87 Other disorders of veins	0.518	0.482	0.000
Y46 Antiepileptics and anti-Parkinsonism drugs	0.517	0.483	0.000
X10-X19 Contact with heat and hot substances	0.515	0.484	0.000
L42 Pityriasis rosea	0.434	0.485	0.080
W10 Fall on and from stairs and steps	0.514	0.485	0.000
Y54.5 Other diuretics	0.514	0.486	0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere	0.514	0.486	0.000
E64 Sequelae of malnutrition and other nutritional deficiencies	0.513	0.486	0.000
E63 Other nutritional deficiencies	0.513	0.486	0.000
E56 Other vitamin deficiencies	0.513	0.486	0.000
E51 Thiamine deficiency	0.513	0.486	0.000
E50 Vitamin A deficiency	0.513	0.486	0.000
E60 Dietary zinc deficiency	0.513	0.486	0.000
E59 Dietary selenium deficiency	0.513	0.486	0.000
E54 Ascorbic acid deficiency	0.513	0.486	0.000
E52 Niacin deficiency [pellagra]	0.513	0.486	0.000
I70.2 Atherosclerosis of arteries of the extremities	0.513	0.487	0.000
L73 Other follicular disorders	0.513	0.487	0.000
W50-W64 Exposure to animate mechanical forces	0.513	0.487	0.000
Q89 Other congenital malformations, not elsewhere classified	0.512	0.488	0.000
Y44.0 Iron preparations and other anti-hypochromic-anaemia preparations	0.512	0.488	0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.511	0.489	0.000
E03.8 Other specified hypothyroidism	0.510	0.490	0.000
I98.2 Oesophageal varices in diseases classified elsewhere	0.509	0.491	0.000
F50 Eating disorders	0.509	0.491	0.000
F69 Unspecified disorder of adult personality and behaviour	0.509	0.491	0.000
Y53 Agents primarily affecting the gastro-intestinal system	0.508	0.492	0.000
Q25.1 Coarctation of aorta	0.508	0.492	0.000
I89 Other non-infective disorders of lymphatic vessels and lymph nodes	0.508	0.492	0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.508	0.492	0.000
W08 Fall involving other furniture	0.508	0.492	0.000
I69.8 Sequelae of other and unspecified cerebrovascular diseases	0.508	0.492	0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence	0.507	0.492	0.000
G25.9 Extrapyramidal and movement disorder, unspecified	0.507	0.493	0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.506	0.494	0.000
F19 Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances	0.506	0.494	0.000
V10-V19 Pedal cyclist injured in transport accident	0.506	0.494	0.000
Y79 Orthopaedic devices associated with adverse incidents	0.505	0.494	0.000
F11.1 Harmful use	0.504	0.496	0.000
L10-L14 Bullous disorders	0.503	0.497	0.000
E20 Hypoparathyroidism	0.503	0.497	0.000
E67 Other hyperalimentation	0.502	0.497	0.000
E68 Sequelae of hyperalimentation	0.502	0.497	0.000
F51 Nonorganic sleep disorders	0.502	0.498	0.000
Y58 Bacterial vaccines	0.502	0.498	0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system	0.502	0.498	0.000
Y50 Central nervous system stimulants, not elsewhere classified	0.502	0.498	0.000
L68 Hypertrichosis	0.502	0.498	0.000
L24 Irritant contact dermatitis	0.502	0.498	0.000
L26 Exfoliative dermatitis	0.502	0.498	0.000
L22 Diaper [napkin] dermatitis	0.502	0.498	0.000
V47 Car occupant injured in collision with fixed or stationary object	0.502	0.498	0.000
V46 Car occupant injured in collision with other nonmotor vehicle	0.502	0.498	0.000
V45 Car occupant injured in collision with railway train or railway vehicle	0.502	0.498	0.000
V42 Car occupant injured in collision with two- or three-wheeled motor vehicle	0.502	0.498	0.000
V41 Car occupant injured in collision with pedal cycle	0.502	0.498	0.000
V40 Car occupant injured in collision with pedestrian or animal	0.502	0.498	0.000
E70.9 Disorder of aromatic amino-acid metabolism, unspecified	0.501	0.499	0.000
E70.8 Other disorders of aromatic amino-acid metabolism	0.501	0.499	0.000
E70.3 Albinism	0.501	0.499	0.000
E70.2 Disorders of tyrosine metabolism	0.501	0.499	0.000
E70.1 Other hyperphenylalaninaemias	0.501	0.499	0.000
E70.0 Classical phenylketonuria	0.501	0.499	0.000
E71.3 Disorders of fatty-acid metabolism	0.501	0.499	0.000
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified	0.501	0.499	0.000
E71.1 Other disorders of branched-chain amino-acid metabolism	0.501	0.499	0.000
E71.0 Maple-syrup-urine disease	0.501	0.499	0.000
E72.9 Disorder of amino-acid metabolism, unspecified	0.501	0.499	0.000
E72.8 Other specified disorders of amino-acid metabolism	0.501	0.499	0.000
E72.5 Disorders of glycine metabolism	0.501	0.499	0.000
E72.4 Disorders of ornithine metabolism	0.501	0.499	0.000
E72.3 Disorders of lysine and hydroxylysine metabolism	0.501	0.499	0.000
E72.2 Disorders of urea cycle metabolism	0.501	0.499	0.000
E72.1 Disorders of sulphur-bearing amino-acid metabolism	0.501	0.499	0.000
E72.0 Disorders of amino-acid transport	0.501	0.499	0.000
E75.6 Lipid storage disorder, unspecified	0.501	0.499	0.000
E75.5 Other lipid storage disorders	0.501	0.499	0.000
E75.4 Neuronal ceroid lipofuscinosis	0.501	0.499	0.000
E75.3 Sphingolipidosis, unspecified	0.501	0.499	0.000
E75.2 Other sphingolipidosis	0.501	0.499	0.000
E75.1 Other gangliosidosis	0.501	0.499	0.000
E75.0 GM2 gangliosidosis	0.501	0.499	0.000
E76.9 Disorder of glucosaminoglycan metabolism, unspecified	0.501	0.499	0.000
E76.8 Other disorders of glucosaminoglycan metabolism	0.501	0.499	0.000
E76.3 Mucopolysaccharidosis, unspecified	0.501	0.499	0.000
E76.2 Other mucopolysaccharidoses	0.501	0.499	0.000
E76.1 Mucopolysaccharidosis, type II	0.501	0.499	0.000
E76.0 Mucopolysaccharidosis, type I	0.501	0.499	0.000
E77.9 Disorder of glycoprotein metabolism, unspecified	0.501	0.499	0.000
E77.8 Other disorders of glycoprotein metabolism	0.501	0.499	0.000
E77.1 Defects in glycoprotein degradation	0.501	0.499	0.000
E77.0 Defects in posttranslational modification of lysosomal enzymes	0.501	0.499	0.000
E79.9 Disorder of purine and pyrimidine metabolism, unspecified	0.501	0.499	0.000
E79.8 Other disorders of purine and pyrimidine metabolism	0.501	0.499	0.000
E79.1 Lesch-Nyhan syndrome	0.501	0.499	0.000
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease	0.501	0.499	0.000
E07 Other disorders of thyroid	0.500	0.500	0.000
G25.3 Myoclonus	0.499	0.501	0.000
I72.4 Aneurysm of artery of lower extremity	0.498	0.502	0.000
E25 Adrenogenital disorders	0.497	0.502	0.000
L29.0 Pruritus ani	0.497	0.503	0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure	0.495	0.504	0.000
Q23.1 Congenital insufficiency of aortic valve	0.495	0.505	0.000
I68 Cerebrovascular disorders in diseases classified elsewhere	0.495	0.505	0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction	0.495	0.505	0.000
L23 Allergic contact dermatitis	0.495	0.505	0.000
Q24.8 Other specified congenital malformations of heart	0.495	0.505	0.000
F18 Mental and behavioural disorders due to use of volatile solvents	0.495	0.505	0.000
F16 Mental and behavioural disorders due to use of hallucinogens	0.495	0.505	0.000
F15 Mental and behavioural disorders due to use of other stimulants, including caffeine	0.495	0.505	0.000
F14 Mental and behavioural disorders due to use of cocaine	0.495	0.505	0.000
F13 Mental and behavioural disorders due to use of sedatives or hypnotics	0.495	0.505	0.000
I72.3 Aneurysm of iliac artery	0.495	0.505	0.000
Y41.8 Other specified systemic anti-infectives and antiparasitics	0.494	0.506	0.000
I78 Diseases of capillaries	0.494	0.506	0.000
L03.2 Cellulitis of face	0.493	0.507	0.000
Q25.0 Patent ductus arteriosus	0.493	0.507	0.000
L66 Cicatricial alopecia [scarring hair loss]	0.492	0.508	0.000
L43 Lichen planus	0.434	0.508	0.059
L20.9 Atopic dermatitis, unspecified	0.492	0.508	0.000
F70-F79 Mental retardation	0.491	0.509	0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified	0.491	0.509	0.000
Y45.3 Other nonsteroidal anti-inflammatory drugs [NSAID]	0.491	0.509	0.000
L04.0 Acute lymphadenitis of face, head and neck	0.491	0.509	0.000
L44 Other papulosquamous disorders	0.390	0.510	0.099
L41 Parapsoriasis	0.390	0.510	0.099
L45 Papulosquamous disorders in diseases classified elsewhere	0.390	0.510	0.099
Y45.9 Analgesic, antipyretic and anti-inflammatory drug, unspecified	0.490	0.510	0.000
Y45.4 Antirheumatics	0.490	0.510	0.000
Y44.3 Anticoagulant antagonists, vitamin K and other coagulants	0.490	0.510	0.000
W06 Fall involving bed	0.488	0.512	0.000
I70.20 Atherosclerosis of arteries of extremities (without gangrene)	0.488	0.512	0.000
E74.9 Disorder of carbohydrate metabolism, unspecified	0.487	0.513	0.000
E74.8 Other specified disorders of carbohydrate metabolism	0.487	0.513	0.000
E74.4 Disorders of pyruvate metabolism and gluconeogenesis	0.487	0.513	0.000
E74.2 Disorders of galactose metabolism	0.487	0.513	0.000
E74.1 Disorders of fructose metabolism	0.487	0.513	0.000
E74.0 Glycogen storage disease	0.487	0.513	0.000
Q30-Q34 Congenital malformations of the respiratory system	0.487	0.513	0.000
E00.9 Congenital iodine-deficiency syndrome, unspecified	0.487	0.513	0.000
E00.2 Congenital iodine-deficiency syndrome, mixed type	0.487	0.513	0.000
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type	0.487	0.513	0.000
E00.0 Congenital iodine-deficiency syndrome, neurological type	0.487	0.513	0.000
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions	0.487	0.513	0.000
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified	0.487	0.513	0.000
E01.1 Iodine-deficiency-related multinodular (endemic) goitre	0.487	0.513	0.000
E01.0 Iodine-deficiency-related diffuse (endemic) goitre	0.487	0.513	0.000
I88.0 Nonspecific mesenteric lymphadenitis	0.486	0.514	0.000
F10.8 Other mental and behavioural disorders	0.486	0.514	0.000
F10.7 Residual and late-onset psychotic disorder	0.486	0.514	0.000
G05 Encephalitis, myelitis and encephalomyelitis in diseases classified elsewhere	0.486	0.514	0.000
Y54.4 Loop [high-ceiling] diuretics	0.486	0.514	0.000
I65.9 Occlusion and stenosis of unspecified precerebral artery	0.485	0.515	0.000
I65.8 Occlusion and stenosis of other precerebral artery	0.485	0.515	0.000
Y49 Psychotropic drugs, not elsewhere classified	0.485	0.515	0.000
G82 Paraplegia and tetraplegia	0.485	0.515	0.000
E88.1 Lipodystrophy, not elsewhere classified	0.485	0.515	0.000
F01 Vascular dementia	0.484	0.516	0.000
E26 Hyperaldosteronism	0.484	0.516	0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.483	0.516	0.000
X42 Accidental poisoning by and exposure to narcotics and psychodysleptics [hallucinogens], not elsewhere classified	0.482	0.518	0.000
Y40 Systemic antibiotics	0.482	0.518	0.000
X47 Accidental poisoning by and exposure to other gases and vapours	0.481	0.519	0.000
I83.1 Varicose veins of lower extremities with inflammation	0.480	0.520	0.000
I85.9 Oesophageal varices without bleeding	0.480	0.520	0.000
X20-X29 Contact with venomous animals and plants	0.480	0.520	0.000
E34.0 Carcinoid syndrome	0.479	0.521	0.000
W01 Fall on same level from slipping, tripping and stumbling	0.479	0.521	0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system	0.478	0.522	0.000
I88.9 Nonspecific lymphadenitis, unspecified	0.478	0.522	0.000
L75 Apocrine sweat disorders	0.477	0.522	0.000
L74 Eccrine sweat disorders	0.477	0.522	0.000
L67 Hair colour and hair shaft abnormalities	0.477	0.522	0.000
L64 Androgenic alopecia	0.477	0.522	0.000
L62 Nail disorders in diseases classified elsewhere	0.477	0.522	0.000
X49 Accidental poisoning by and exposure to other and unspecified chemicals and noxious substances	0.477	0.523	0.000
Y51 Drugs primarily affecting the autonomic nervous system	0.477	0.523	0.000
L04.8 Acute lymphadenitis of other sites	0.476	0.523	0.000
L04.3 Acute lymphadenitis of lower limb	0.476	0.523	0.000
L04.2 Acute lymphadenitis of upper limb	0.476	0.523	0.000
G23 Other degenerative diseases of basal ganglia	0.476	0.524	0.000
G21 Secondary Parkinsonism	0.476	0.524	0.000
G26 Extrapyramidal and movement disorders in diseases classified elsewhere	0.476	0.524	0.000
G22 Parkinsonism in diseases classified elsewhere	0.476	0.524	0.000
G37 Other demyelinating diseases of central nervous system	0.475	0.525	0.000
L65 Other nonscarring hair loss	0.475	0.525	0.000
L03.8 Cellulitis of other sites	0.474	0.526	0.000
G30 Alzheimer's disease	0.473	0.527	0.000
L03.3 Cellulitis of trunk	0.473	0.527	0.000
L70 Acne	0.472	0.528	0.000
F60 Specific personality disorders	0.472	0.528	0.000
Q26 Congenital malformations of great veins	0.471	0.529	0.000
Q22 Congenital malformations of pulmonary and tricuspid valves	0.471	0.529	0.000
Q20 Congenital malformations of cardiac chambers and connexions	0.471	0.529	0.000
Q89.2 Congenital malformations of other endocrine glands	0.471	0.529	0.000
F07 Personality and behavioural disorders due to brain disease, damage and dysfunction	0.471	0.529	0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.470	0.530	0.000
V49.8 Car occupant [any] injured in other specified transport accidents	0.470	0.530	0.000
V49.3 Car occupant [any] injured in unspecified nontraffic accident	0.470	0.530	0.000
V49.2 Unspecified car occupant injured in collision with other and unspecified motor vehicles in nontraffic accident	0.470	0.530	0.000
V49.1 Passenger injured in collision with other and unspecified motor vehicles in nontraffic accident	0.470	0.530	0.000
V49.0 Driver injured in collision with other and unspecified motor vehicles in nontraffic accident	0.470	0.530	0.000
X41 Accidental poisoning by and exposure to antiepileptic, sedative-hypnotic, anti-Parkinsonism and psychotropic drugs, not elsewhere classified	0.470	0.530	0.000
F52 Sexual dysfunction, not caused by organic disorder or disease	0.469	0.531	0.000
L29.3 Anogenital pruritus, unspecified	0.469	0.531	0.000
L29.1 Pruritus scroti	0.469	0.531	0.000
X44 Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances	0.468	0.531	0.000
Y54.7 Agents affecting calcification	0.468	0.531	0.000
I74 Arterial embolism and thrombosis	0.468	0.532	0.000
F00 Dementia in Alzheimer's disease	0.468	0.532	0.000
Y00-Y09 Assault	0.467	0.532	0.000
E74.3 Other disorders of intestinal carbohydrate absorption	0.467	0.533	0.000
I07 Rheumatic tricuspid valve diseases	0.467	0.533	0.000
W18 Other fall on same level	0.466	0.534	0.000
Y48.3 Local anaesthetics	0.466	0.534	0.000
W10.8 Other specified place	0.466	0.534	0.000
Y44.9 Other and unspecified agents affecting blood constituents	0.465	0.534	0.000
Y44.7 Plasma substitutes	0.465	0.534	0.000
Y44.6 Natural blood and blood products	0.465	0.534	0.000
Y44.5 Thrombolytic drugs	0.465	0.534	0.000
Y44.4 Antithrombotic drugs [platelet-aggregation inhibitors]	0.465	0.534	0.000
Y44.1 Vitamin B12, folic acid and other anti-megaloblastic-anaemia preparations	0.465	0.534	0.000
V49.5 Passenger injured in collision with other and unspecified motor vehicles in traffic accident	0.464	0.536	0.000
L71.0 Perioral dermatitis	0.464	0.536	0.000
G06.1 Intraspinal abscess and granuloma	0.464	0.536	0.000
E35 Disorders of endocrine glands in diseases classified elsewhere	0.462	0.538	0.000
E32 Diseases of thymus	0.462	0.538	0.000
E31 Polyglandular dysfunction	0.462	0.538	0.000
E30 Disorders of puberty, not elsewhere classified	0.462	0.538	0.000
I69.0 Sequelae of subarachnoid haemorrhage	0.462	0.538	0.000
E27.2 Addisonian crisis	0.462	0.538	0.000
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere	0.461	0.539	0.000
I71 Aortic aneurysm and dissection	0.460	0.540	0.000
L30 Other dermatitis	0.459	0.541	0.000
Y45.1 Salicylates	0.459	0.541	0.000
I72.8 Aneurysm of other specified arteries	0.458	0.542	0.000
L03.9 Cellulitis, unspecified	0.457	0.543	0.000
I62 Other nontraumatic intracranial haemorrhage	0.457	0.543	0.000
V22 Motorcycle rider injured in collision with two- or three-wheeled motor vehicle	0.456	0.543	0.000
F02 Dementia in other diseases classified elsewhere	0.456	0.544	0.000
I82 Other venous embolism and thrombosis	0.456	0.544	0.000
G25.6 Drug-induced tics and other tics of organic origin	0.456	0.544	0.000
G25.5 Other chorea	0.456	0.544	0.000
G25.4 Drug-induced chorea	0.456	0.544	0.000
G25.2 Other specified forms of tremor	0.456	0.544	0.000
G25.1 Drug-induced tremor	0.456	0.544	0.000
E28 Ovarian dysfunction	0.456	0.544	0.000
F53 Mental and behavioural disorders associated with the puerperium, not elsewhere classified	0.455	0.545	0.000
F59 Unspecified behavioural syndromes associated with physiological disturbances and physical factors	0.455	0.545	0.000
F54 Psychological and behavioural factors associated with disorders or diseases classified elsewhere	0.455	0.545	0.000
E88.9 Metabolic disorder, unspecified	0.455	0.545	0.000
E88.8 Other specified metabolic disorders	0.455	0.545	0.000
E88.3 Tumour lysis syndrome	0.455	0.545	0.000
E88.2 Lipomatosis, not elsewhere classified	0.455	0.545	0.000
E06.9 Thyroiditis, unspecified	0.454	0.546	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations