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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2523500
log Bayes Factor = 75.3256
Chromosome 6   position 31,518,354  (GRCh37) Explore rs2523500 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.000 1.000
I20 Angina pectoris
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E11.9 Without complications
0.000 0.001 0.999
E14 Unspecified diabetes mellitus
0.000 0.001 0.999
E05.9 Thyrotoxicosis, unspecified
0.000 0.001 0.999
E10.1 With ketoacidosis
0.000 0.001 0.999
I20.0 Unstable angina
0.000 0.001 0.999
E78.0 Pure hypercholesterolaemia
0.000 0.003 0.997
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.003 0.997
E70-E90 Metabolic disorders
0.000 0.003 0.997
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.003 0.997
M06.9 Rheumatoid arthritis, unspecified
0.000 0.003 0.997
I20.9 Angina pectoris, unspecified
0.000 0.004 0.996
E10.4 With neurological complications
0.000 0.004 0.996
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.006 0.994
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.009 0.991
E14.3 With ophthalmic complications
0.000 0.016 0.984
I22 Subsequent myocardial infarction
0.000 0.020 0.980
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.028 0.972
I25.5 Ischaemic cardiomyopathy
0.000 0.028 0.972
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.029 0.971
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.039 0.961
I21 Acute myocardial infarction
0.000 0.042 0.958
E14.9 Without complications
0.000 0.045 0.955
E11.1 With ketoacidosis
0.000 0.048 0.952
E16 Other disorders of pancreatic internal secretion
0.000 0.050 0.950
I21.9 Acute myocardial infarction, unspecified
0.000 0.050 0.950
E10.2 With renal complications
0.000 0.061 0.939
I25.2 Old myocardial infarction
0.000 0.062 0.938
E16.2 Hypoglycaemia, unspecified
0.000 0.072 0.928
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.086 0.914
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.098 0.902
E11.3 With ophthalmic complications
0.000 0.110 0.890
E14.4 With neurological complications
0.000 0.119 0.881
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.123 0.877
E06 Thyroiditis
0.000 0.127 0.873
E11.2 With renal complications
0.000 0.130 0.870
I24 Other acute ischaemic heart diseases
0.000 0.138 0.862
M06 Other rheumatoid arthritis
0.000 0.142 0.858
E78.2 Mixed hyperlipidaemia
0.000 0.142 0.858
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.144 0.856
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.145 0.855
E10.0 With coma
0.000 0.145 0.855
E11.0 With coma
0.000 0.155 0.845
E13 Other specified diabetes mellitus
0.000 0.157 0.843
E78.1 Pure hyperglyceridaemia
0.000 0.160 0.840
E40-E46 Malnutrition
0.000 0.163 0.837
E86 Volume depletion
0.000 0.168 0.832
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.173 0.827
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.177 0.823
E14.6 With other specified complications
0.000 0.186 0.814
E14.8 With unspecified complications
0.000 0.188 0.812
E06.3 Autoimmune thyroiditis
0.000 0.198 0.802
E83.1 Disorders of iron metabolism
0.799 0.201 0.000
E10.8 With unspecified complications
0.000 0.204 0.796
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.208 0.792
E10.5 With peripheral circulatory complications
0.000 0.216 0.784
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.217 0.783
E88 Other metabolic disorders
0.000 0.218 0.782
M06.3 Rheumatoid nodule
0.000 0.224 0.776
I23 Certain current complications following acute myocardial infarction
0.000 0.227 0.773
E14.1 With ketoacidosis
0.000 0.228 0.772
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.234 0.766
M06.0 Seronegative rheumatoid arthritis
0.000 0.242 0.758
E78.6 Lipoprotein deficiency
0.000 0.249 0.751
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.251 0.749
E74 Other disorders of carbohydrate metabolism
0.000 0.254 0.746
I24.8 Other forms of acute ischaemic heart disease
0.000 0.254 0.746
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.257 0.743
E14.5 With peripheral circulatory complications
0.000 0.257 0.743
E78.4 Other hyperlipidaemia
0.000 0.261 0.739
I25.6 Silent myocardial ischaemia
0.000 0.265 0.735
E73 Lactose intolerance
0.000 0.265 0.735
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.265 0.735
E10.6 With other specified complications
0.000 0.266 0.734
E46 Unspecified protein-energy malnutrition
0.000 0.280 0.720
E13.9 Without complications
0.000 0.282 0.718
E10.7 With multiple complications
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.716
E78.3 Hyperchylomicronaemia
0.000 0.285 0.715
E77 Disorders of glycoprotein metabolism
0.000 0.285 0.715
E76 Disorders of glycosaminoglycan metabolism
0.000 0.285 0.715
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.285 0.715
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.285 0.715
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.285 0.715
E14.2 Withrenal complications
0.000 0.292 0.708
E79 Disorders of purine and pyrimidine metabolism
0.000 0.293 0.707
E70 Disorders of aromatic amino-acid metabolism
0.000 0.299 0.701
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.301 0.699
E15 Nondiabetic hypoglycaemic coma
0.000 0.304 0.696
E84 Cystic fibrosis
0.000 0.313 0.687
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.313 0.687
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.313 0.687
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.316 0.684
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.319 0.681
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.319 0.681
E16.4 Abnormal secretion of gastrin
0.000 0.319 0.681
E16.3 Increased secretion of glucagon
0.000 0.319 0.681
E89.3 Postprocedural hypopituitarism
0.000 0.324 0.676
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.325 0.675
E72 Other disorders of amino-acid metabolism
0.000 0.326 0.674
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.326 0.674
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.326 0.674
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.340 0.660
M06.34 Rheumatoid nodule (Hand)
0.000 0.344 0.656
E06.5 Other chronic thyroiditis
0.000 0.350 0.650
L40.5 Arthropathic psoriasis
0.000 0.354 0.646
E16.1 Other hypoglycaemia
0.000 0.358 0.642
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.359 0.641
I20.1 Angina pectoris with documented spasm
0.000 0.361 0.639
I25.4 Coronary artery aneurysm
0.000 0.362 0.638
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.367 0.633
L40 Psoriasis
0.000 0.368 0.632
I22.8 Subsequent myocardial infarction of other sites
0.000 0.371 0.628
E13.3 With ophthalmic complications
0.000 0.372 0.627
E06.4 Drug-induced thyroiditis
0.000 0.374 0.626
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.374 0.626
E06.0 Acute thyroiditis
0.000 0.374 0.626
E78.8 Other disorders of lipoprotein metabolism
0.000 0.376 0.624
E14.0 With coma
0.000 0.383 0.617
M06.8 Other specified rheumatoid arthritis
0.000 0.384 0.615
M06.2 Rheumatoid bursitis
0.000 0.384 0.615
M06.1 Adult-onset Still's disease
0.000 0.384 0.615
E80.6 Other disorders of bilirubin metabolism
0.000 0.388 0.612
I23.8 Other current complications following acute myocardial infarction
0.000 0.390 0.610
E88.2 Lipomatosis, not elsewhere classified
0.000 0.390 0.610
E13.8 With unspecified complications
0.000 0.396 0.604
E13.7 With multiple complications
0.000 0.396 0.604
E13.6 With other specified complications
0.000 0.396 0.604
E13.5 With peripheral circulatory complications
0.000 0.396 0.604
E13.4 With neurological complications
0.000 0.396 0.604
E13.2 With renal complications
0.000 0.396 0.604
E13.1 With ketoacidosis
0.000 0.396 0.604
E13.0 With coma
0.000 0.396 0.604
E89.0 Postprocedural hypothyroidism
0.000 0.396 0.604
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.400 0.600
E45 Retarded development following protein-energy malnutrition
0.000 0.400 0.600
E43 Unspecified severe protein-energy malnutrition
0.000 0.400 0.600
E42 Marasmic kwashiorkor
0.000 0.400 0.600
E41 Nutritional marasmus
0.000 0.400 0.600
E40 Kwashiorkor
0.000 0.400 0.600
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.401 0.599
L40-L45 Papulosquamous disorders
0.000 0.406 0.594
E06.9 Thyroiditis, unspecified
0.000 0.407 0.593
E88.9 Metabolic disorder, unspecified
0.000 0.410 0.590
E20-E35 Disorders of other endocrine glands
0.000 0.410 0.590
L43 Lichen planus
0.000 0.414 0.586
L40.9 Psoriasis, unspecified
0.000 0.416 0.584
E11.5 With peripheral circulatory complications
0.000 0.417 0.583
E11.6 With other specified complications
0.000 0.419 0.581
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.422 0.578
E88.8 Other specified metabolic disorders
0.000 0.424 0.576
E88.3 Tumour lysis syndrome
0.000 0.427 0.573
L43.9 Lichen planus, unspecified
0.000 0.428 0.572
E89.4 Postprocedural ovarian failure
0.000 0.431 0.569
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.431 0.569
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.433 0.567
E06.1 Subacute thyroiditis
0.000 0.434 0.565
M06.4 Inflammatory polyarthropathy
0.000 0.443 0.556
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.443 0.556
M06.38 Rheumatoid nodule (Other)
0.000 0.443 0.556
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.443 0.556
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.443 0.556
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.443 0.556
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.446 0.554
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.446 0.554
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.446 0.554
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.446 0.554
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.446 0.554
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.446 0.554
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.446 0.554
E03.1 Congenital hypothyroidism without goitre
0.000 0.447 0.552
E11.8 With unspecified complications
0.000 0.450 0.550
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.450 0.549
E89.5 Postprocedural testicular hypofunction
0.000 0.450 0.549
E89.1 Postprocedural hypoinsulinaemia
0.000 0.450 0.549
E73.9 Lactose intolerance, unspecified
0.000 0.453 0.547
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.454 0.545
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.456 0.544
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.456 0.544
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.456 0.544
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.456 0.544
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.456 0.544
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.457 0.543
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.458 0.542
E85 Amyloidosis
0.000 0.458 0.541
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.465 0.535
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.465 0.535
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.465 0.535
E74.2 Disorders of galactose metabolism
0.000 0.465 0.535
E74.1 Disorders of fructose metabolism
0.000 0.465 0.535
E74.0 Glycogen storage disease
0.000 0.465 0.535
E07 Other disorders of thyroid
0.000 0.473 0.527
E73.8 Other lactose intolerance
0.000 0.473 0.527
E73.1 Secondary lactase deficiency
0.000 0.473 0.527
E73.0 Congenital lactase deficiency
0.000 0.473 0.527
E23 Hypofunction and other disorders of pituitary gland
0.000 0.475 0.525
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.477 0.523
E03.8 Other specified hypothyroidism
0.000 0.477 0.523
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.479 0.521
E80.1 Porphyria cutanea tarda
0.000 0.480 0.520
E05.8 Other thyrotoxicosis
0.000 0.485 0.515
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.487 0.513
E71.3 Disorders of fatty-acid metabolism
0.000 0.487 0.512
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.487 0.512
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.487 0.512
E71.0 Maple-syrup-urine disease
0.000 0.487 0.512
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.487 0.512
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.487 0.512
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.487 0.512
E76.2 Other mucopolysaccharidoses
0.000 0.487 0.512
E76.1 Mucopolysaccharidosis, type II
0.000 0.487 0.512
E76.0 Mucopolysaccharidosis, type I
0.000 0.487 0.512
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.487 0.512
E77.8 Other disorders of glycoprotein metabolism
0.000 0.487 0.512
E77.1 Defects in glycoprotein degradation
0.000 0.487 0.512
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.487 0.512
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.487 0.512
E80.5 Crigler-Najjar syndrome
0.000 0.487 0.512
E80.3 Defects of catalase and peroxydase
0.000 0.487 0.512
E80.0 Hereditary erythropoietic porphyria
0.000 0.487 0.512
E80.2 Other porphyria
0.000 0.488 0.512
L43.8 Other lichen planus
0.000 0.493 0.507
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.493 0.507
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.493 0.507
E79.1 Lesch-Nyhan syndrome
0.000 0.493 0.507
I21.4 Acute subendocardial myocardial infarction
0.000 0.497 0.503
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.497 0.502
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.497 0.502
E70.2 Disorders of tyrosine metabolism
0.000 0.497 0.502
E70.1 Other hyperphenylalaninaemias
0.000 0.497 0.502
E70.0 Classical phenylketonuria
0.000 0.497 0.502
I25.3 Aneurysm of heart
0.000 0.499 0.500
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.500 0.500
L40.8 Other psoriasis
0.000 0.501 0.499
E84.8 Cystic fibrosis with other manifestations
0.000 0.507 0.493
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.507 0.493
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.507 0.493
E70.3 Albinism
0.000 0.511 0.489
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.512 0.488
E65-E68 Obesity and other hyperalimentation
0.000 0.515 0.485
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.516 0.483
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.516 0.483
E72.5 Disorders of glycine metabolism
0.000 0.516 0.483
E72.4 Disorders of ornithine metabolism
0.000 0.516 0.483
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.516 0.483
E72.2 Disorders of urea cycle metabolism
0.000 0.516 0.483
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.516 0.483
E23.6 Other disorders of pituitary gland
0.000 0.517 0.483
E75.6 Lipid storage disorder, unspecified
0.000 0.517 0.483
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.517 0.483
E75.3 Sphingolipidosis, unspecified
0.000 0.517 0.483
E75.2 Other sphingolipidosis
0.000 0.517 0.483
E75.1 Other gangliosidosis
0.000 0.517 0.483
E75.0 GM2 gangliosidosis
0.000 0.517 0.483
M06.33 Rheumatoid nodule (Forearm)
0.000 0.521 0.478
I24.1 Dressler's syndrome
0.000 0.522 0.478
L40.4 Guttate psoriasis
0.000 0.528 0.472
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.531 0.469
E84.9 Cystic fibrosis, unspecified
0.000 0.535 0.465
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.540 0.460
E24 Cushing's syndrome
0.000 0.540 0.460
L40.3 Pustulosis palmaris et plantaris
0.000 0.541 0.459
L40.2 Acrodermatitis continua
0.000 0.546 0.453
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.548 0.452
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.548 0.452
E72.0 Disorders of amino-acid transport
0.000 0.557 0.443
E75.5 Other lipid storage disorders
0.000 0.558 0.442
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.558 0.441
M06.18 Adult-onset Still's disease (Other)
0.000 0.558 0.441
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.558 0.441
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.558 0.441
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.558 0.441
M06.14 Adult-onset Still's disease (Hand)
0.000 0.558 0.441
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.558 0.441
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.558 0.441
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.558 0.441
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.558 0.441
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.558 0.441
M06.28 Rheumatoid bursitis (Other)
0.000 0.558 0.441
M06.27 Rheumatoid bursitis (Ankle and foot)
0.000 0.558 0.441
M06.26 Rheumatoid bursitis (Lower leg)
0.000 0.558 0.441
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.000 0.558 0.441
M06.24 Rheumatoid bursitis (Hand)
0.000 0.558 0.441
M06.23 Rheumatoid bursitis (Forearm)
0.000 0.558 0.441
M06.22 Rheumatoid bursitis (Upper arm)
0.000 0.558 0.441
M06.21 Rheumatoid bursitis (Shoulder region)
0.000 0.558 0.441
M06.20 Rheumatoid bursitis (Multiple sites)
0.000 0.558 0.441
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.000 0.558 0.441
M06.88 Other specified rheumatoid arthritis (Other)
0.000 0.558 0.441
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.000 0.558 0.441
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.000 0.558 0.441
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.000 0.558 0.441
M06.84 Other specified rheumatoid arthritis (Hand)
0.000 0.558 0.441
M06.83 Other specified rheumatoid arthritis (Forearm)
0.000 0.558 0.441
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.000 0.558 0.441
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.000 0.558 0.441
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.000 0.558 0.441
L42 Pityriasis rosea
0.000 0.559 0.441
L40.1 Generalised pustular psoriasis
0.000 0.564 0.436
E28 Ovarian dysfunction
0.000 0.564 0.436
E44.1 Mild protein-energy malnutrition
0.000 0.570 0.430
E44.0 Moderate protein-energy malnutrition
0.000 0.570 0.430
E23.7 Disorder of pituitary gland, unspecified
0.000 0.570 0.430
E22 Hyperfunction of pituitary gland
0.000 0.571 0.429
L44 Other papulosquamous disorders
0.000 0.574 0.426
L41 Parapsoriasis
0.000 0.574 0.426
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.574 0.426
E23.2 Diabetes insipidus
0.000 0.575 0.425
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.577 0.423
E32 Diseases of thymus
0.000 0.577 0.423
E31 Polyglandular dysfunction
0.000 0.577 0.423
E30 Disorders of puberty, not elsewhere classified
0.000 0.577 0.423
E26 Hyperaldosteronism
0.000 0.578 0.422
E21.3 Hyperparathyroidism, unspecified
0.000 0.579 0.421
L43.3 Subacute (active) lichen planus
0.000 0.580 0.420
L43.2 Lichenoid drug reaction
0.000 0.580 0.420
L43.1 Bullous lichen planus
0.000 0.580 0.420
L43.0 Hypertrophic lichen planus
0.000 0.580 0.420
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.580 0.419
E85.4 Organ-limited amyloidosis
0.000 0.587 0.413
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.596 0.404
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.601 0.399
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.601 0.399
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.601 0.399
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.601 0.399
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.601 0.399
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.601 0.399
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.601 0.399
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.601 0.399
H36.0 Diabetic retinopathy
0.000 0.604 0.396
K90 Intestinal malabsorption
0.000 0.608 0.392
E07.8 Other specified disorders of thyroid
0.000 0.609 0.390
E20 Hypoparathyroidism
0.000 0.611 0.389
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.612 0.388
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.612 0.388
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.612 0.388
L40.0 Psoriasis vulgaris
0.000 0.617 0.382
E07.1 Dyshormogenetic goitre
0.000 0.622 0.378
E07.0 Hypersecretion of calcitonin
0.000 0.622 0.378
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.623 0.377
E23.1 Drug-induced hypopituitarism
0.000 0.623 0.377
E25 Adrenogenital disorders
0.000 0.624 0.376
E24.2 Drug-induced Cushing's syndrome
0.000 0.630 0.370
E65 Localised adiposity
0.000 0.633 0.367
E24.0 Pituitary-dependent Cushing's disease
0.000 0.634 0.366
E21.2 Other hyperparathyroidism
0.000 0.637 0.362
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.639 0.361
E22.0 Acromegaly and pituitary gigantism
0.000 0.645 0.355
E28.2 Polycystic ovarian syndrome
0.000 0.648 0.352
E85.9 Amyloidosis, unspecified
0.000 0.648 0.352
E67 Other hyperalimentation
0.000 0.652 0.348
E68 Sequelae of hyperalimentation
0.000 0.652 0.348
E21.4 Other specified disorders of parathyroid gland
0.000 0.655 0.344
E50-E64 Other nutritional deficiencies
0.000 0.657 0.343
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.659 0.341
E83 Disorders of mineral metabolism
0.241 0.669 0.089
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.670 0.330
E24.3 Ectopic ACTH syndrome
0.000 0.670 0.330
E24.1 Nelson's syndrome
0.000 0.670 0.330
E85.3 Secondary systemic amyloidosis
0.000 0.672 0.328
E85.8 Other amyloidosis
0.000 0.683 0.316
E24.8 Other Cushing's syndrome
0.000 0.684 0.316
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.684 0.316
G35 Multiple sclerosis
0.313 0.687 0.000
E28.9 Ovarian dysfunction, unspecified
0.000 0.687 0.313
E28.8 Other ovarian dysfunction
0.000 0.687 0.313
E28.1 Androgen excess
0.000 0.687 0.313
E28.0 Oestrogen excess
0.000 0.687 0.313
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.692 0.308
E22.8 Other hyperfunction of pituitary gland
0.000 0.692 0.308
L41.9 Parapsoriasis, unspecified
0.000 0.694 0.305
L41.8 Other parapsoriasis
0.000 0.694 0.305
L41.5 Retiform parapsoriasis
0.000 0.694 0.305
L41.4 Large plaque parapsoriasis
0.000 0.694 0.305
L41.3 Small plaque parapsoriasis
0.000 0.694 0.305
L41.2 Lymphomatoid papulosis
0.000 0.694 0.305
L41.1 Pityriasis lichenoides chronica
0.000 0.694 0.305
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.694 0.305
L44.9 Papulosquamous disorder, unspecified
0.000 0.694 0.305
L44.8 Other specified papulosquamous disorders
0.000 0.694 0.305
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.694 0.305
L44.3 Lichen ruber moniliformis
0.000 0.694 0.305
L44.2 Lichen striatus
0.000 0.694 0.305
L44.1 Lichen nitidus
0.000 0.694 0.305
L44.0 Pityriasis rubra pilaris
0.000 0.694 0.305
E30.9 Disorder of puberty, unspecified
0.000 0.697 0.303
E30.8 Other disorders of puberty
0.000 0.697 0.303
E30.1 Precocious puberty
0.000 0.697 0.303
E30.0 Delayed puberty
0.000 0.697 0.303
E31.9 Polyglandular dysfunction, unspecified
0.000 0.697 0.303
E31.8 Other polyglandular dysfunction
0.000 0.697 0.303
E31.1 Polyglandular hyperfunction
0.000 0.697 0.303
E31.0 Autoimmune polyglandular failure
0.000 0.697 0.303
E32.9 Disease of thymus, unspecified
0.000 0.697 0.303
E32.8 Other diseases of thymus
0.000 0.697 0.303
E32.1 Abscess of thymus
0.000 0.697 0.303
E32.0 Persistent hyperplasia of thymus
0.000 0.697 0.303
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.697 0.303
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.697 0.303
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.697 0.303
K90.9 Intestinal malabsorption, unspecified
0.000 0.697 0.303
E26.9 Hyperaldosteronism, unspecified
0.000 0.697 0.302
E26.8 Other hyperaldosteronism
0.000 0.697 0.302
E26.1 Secondary hyperaldosteronism
0.000 0.697 0.302
E26.0 Primary hyperaldosteronism
0.000 0.699 0.301
E80.4 Gilbert's syndrome
0.000 0.699 0.300
E24.9 Cushing's syndrome, unspecified
0.000 0.707 0.293
E34 Other endocrine disorders
0.000 0.710 0.290
E27 Other disorders of adrenal gland
0.000 0.711 0.289
M05-M14 Inflammatory polyarthropathies
0.000 0.711 0.289
E29 Testicular dysfunction
0.000 0.716 0.284
K90.3 Pancreatic steatorrhoea
0.000 0.719 0.281
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.719 0.281
K90.1 Tropical sprue
0.000 0.719 0.281
E20.8 Other hypoparathyroidism
0.000 0.721 0.279
E20.1 Pseudohypoparathyroidism
0.000 0.721 0.279
E20.0 Idiopathic hypoparathyroidism
0.000 0.721 0.279
M07 Psoriatic and enteropathic arthropathies
0.000 0.724 0.276
E28.3 Primary ovarian failure
0.000 0.727 0.273
G35-G37 Demyelinating diseases of the central nervous system
0.273 0.727 0.000
E89.2 Postprocedural hypoparathyroidism
0.001 0.728 0.271
E25.9 Adrenogenital disorder, unspecified
0.000 0.730 0.270
E25.8 Other adrenogenital disorders
0.000 0.730 0.270
M07.3 Other psoriatic arthropathies
0.000 0.731 0.269
E61 Deficiency of other nutrient elements
0.000 0.734 0.266
G37 Other demyelinating diseases of central nervous system
0.266 0.734 0.000
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.741 0.259
K90.8 Other intestinal malabsorption
0.000 0.742 0.258
E27.9 Disorder of adrenal gland, unspecified
0.000 0.746 0.254
G37.9 Demyelinating disease of central nervous system, unspecified
0.253 0.747 0.000
E67.8 Other specified hyperalimentation
0.000 0.750 0.250
E67.3 Hypervitaminosis D
0.000 0.750 0.250
E67.2 Megavitamin-B6 syndrome
0.000 0.750 0.250
E67.1 Hypercarotenaemia
0.000 0.750 0.250
E67.0 Hypervitaminosis A
0.000 0.750 0.250
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.754 0.246
E63 Other nutritional deficiencies
0.000 0.754 0.246
E51 Thiamine deficiency
0.000 0.754 0.246
E50 Vitamin A deficiency
0.000 0.754 0.246
E60 Dietary zinc deficiency
0.000 0.754 0.246
E59 Dietary selenium deficiency
0.000 0.754 0.246
E52 Niacin deficiency [pellagra]
0.000 0.754 0.246
E20.9 Hypoparathyroidism, unspecified
0.000 0.755 0.245
E83.9 Disorder of mineral metabolism, unspecified
0.188 0.756 0.056
E56 Other vitamin deficiencies
0.000 0.756 0.244
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.757 0.243
E83.8 Other disorders of mineral metabolism
0.173 0.763 0.064
E83.2 Disorders of zinc metabolism
0.173 0.763 0.064
E83.0 Disorders of copper metabolism
0.173 0.763 0.064
E58 Dietary calcium deficiency
0.000 0.764 0.236
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.765 0.234
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.001 0.768 0.231
E22.1 Hyperprolactinaemia
0.000 0.771 0.229
E61.1 Iron deficiency
0.000 0.776 0.224
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.777 0.223

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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