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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2524079
log Bayes Factor = 131.024
Chromosome 6   position 31,242,174  (GRCh37) Explore rs2524079 on Ensembl!
Variant rs2524079 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
1.000 0.000 0.000
L40.5 Arthropathic psoriasis
1.000 0.000 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
L40 Psoriasis
1.000 0.000 0.000
R31 Unspecified haematuria
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.001 0.999
E00-E07 Disorders of thyroid gland
0.000 0.001 0.999
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.002 0.998
E16 Other disorders of pancreatic internal secretion
0.000 0.003 0.997
E16.2 Hypoglycaemia, unspecified
0.000 0.004 0.996
E10.1 With ketoacidosis
0.000 0.009 0.991
L40.0 Psoriasis vulgaris
0.980 0.020 0.000
E10.2 With renal complications
0.000 0.020 0.980
E20-E35 Disorders of other endocrine glands
0.000 0.028 0.972
E14 Unspecified diabetes mellitus
0.000 0.031 0.969
E03.9 Hypothyroidism, unspecified
0.968 0.032 0.000
E10.4 With neurological complications
0.000 0.036 0.964
E27 Other disorders of adrenal gland
0.000 0.046 0.954
E27.1 Primary adrenocortical insufficiency
0.000 0.049 0.951
E14.3 With ophthalmic complications
0.000 0.070 0.930
E34 Other endocrine disorders
0.000 0.090 0.910
L40.8 Other psoriasis
0.909 0.091 0.000
E05.8 Other thyrotoxicosis
0.000 0.106 0.894
E11 Non-insulin-dependent diabetes mellitus
0.000 0.116 0.884
E29 Testicular dysfunction
0.000 0.124 0.876
E50-E64 Other nutritional deficiencies
0.000 0.127 0.873
K90 Intestinal malabsorption
0.000 0.128 0.872
I26.9 Pulmonary embolism without mention of acute cor pulmonale
0.000 0.135 0.865
E11.5 With peripheral circulatory complications
0.000 0.140 0.860
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.153 0.847
E10.0 With coma
0.000 0.157 0.842
K90.9 Intestinal malabsorption, unspecified
0.000 0.161 0.839
E78.0 Pure hypercholesterolaemia
0.833 0.167 0.000
E20 Hypoparathyroidism
0.000 0.185 0.815
E53 Deficiency of other B group vitamins
0.000 0.186 0.814
E10.6 With other specified complications
0.000 0.190 0.810
E29.1 Testicular hypofunction
0.000 0.193 0.807
E14.2 Withrenal complications
0.000 0.194 0.806
E34.8 Other specified endocrine disorders
0.000 0.204 0.796
E14.6 With other specified complications
0.000 0.206 0.793
E65-E68 Obesity and other hyperalimentation
0.000 0.208 0.792
E10.7 With multiple complications
0.000 0.212 0.788
L40.4 Guttate psoriasis
0.788 0.212 0.000
E14.1 With ketoacidosis
0.000 0.216 0.784
E10.8 With unspecified complications
0.000 0.217 0.783
L40.1 Generalised pustular psoriasis
0.782 0.218 0.000
E34.9 Endocrine disorder, unspecified
0.000 0.235 0.765
E22 Hyperfunction of pituitary gland
0.000 0.241 0.759
E03 Other hypothyroidism
0.416 0.249 0.335
E11.4 With neurological complications
0.000 0.252 0.748
E53.8 Deficiency of other specified B group vitamins
0.000 0.255 0.745
E34.0 Carcinoid syndrome
0.000 0.255 0.745
E10.5 With peripheral circulatory complications
0.000 0.267 0.733
E14.8 With unspecified complications
0.000 0.268 0.732
E11.8 With unspecified complications
0.000 0.276 0.724
E27.8 Other specified disorders of adrenal gland
0.000 0.277 0.723
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.717 0.283 0.000
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.284 0.716
E00 Congenital iodine-deficiency syndrome
0.000 0.284 0.716
E15 Nondiabetic hypoglycaemic coma
0.000 0.284 0.716
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.285 0.715
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.285 0.715
E16.4 Abnormal secretion of gastrin
0.000 0.285 0.715
E16.3 Increased secretion of glucagon
0.000 0.285 0.715
E14.4 With neurological complications
0.000 0.294 0.706
E20.9 Hypoparathyroidism, unspecified
0.000 0.297 0.703
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.303 0.697
E32 Diseases of thymus
0.000 0.303 0.697
E31 Polyglandular dysfunction
0.000 0.303 0.697
E30 Disorders of puberty, not elsewhere classified
0.000 0.303 0.697
E14.7 With multiple complications
0.000 0.305 0.695
E14.0 With coma
0.000 0.305 0.695
E40-E46 Malnutrition
0.000 0.306 0.694
E27.5 Adrenomedullary hyperfunction
0.000 0.316 0.684
E27.0 Other adrenocortical overactivity
0.000 0.316 0.684
E66 Obesity
0.000 0.326 0.674
E53.9 Vitamin B deficiency, unspecified
0.000 0.327 0.673
E14.5 With peripheral circulatory complications
0.000 0.329 0.671
E27.2 Addisonian crisis
0.000 0.336 0.664
E22.0 Acromegaly and pituitary gigantism
0.000 0.338 0.662
E55 Vitamin D deficiency
0.000 0.340 0.660
K90.8 Other intestinal malabsorption
0.000 0.348 0.652
E34.5 Androgen resistance syndrome
0.000 0.348 0.652
E34.4 Constitutional tall stature
0.000 0.348 0.652
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.348 0.652
E34.1 Other hypersecretion of intestinal hormones
0.000 0.348 0.652
E26 Hyperaldosteronism
0.000 0.352 0.647
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.359 0.641
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.364 0.636
E25 Adrenogenital disorders
0.000 0.365 0.635
E11.7 With multiple complications
0.000 0.366 0.634
E11.1 With ketoacidosis
0.000 0.368 0.632
E66.8 Other obesity
0.000 0.371 0.629
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.371 0.629
E29.9 Testicular dysfunction, unspecified
0.000 0.372 0.628
E29.8 Other testicular dysfunction
0.000 0.372 0.628
E29.0 Testicular hyperfunction
0.000 0.372 0.628
E34.3 Short stature, not elsewhere classified
0.000 0.373 0.627
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.374 0.626
E63 Other nutritional deficiencies
0.000 0.374 0.626
E50 Vitamin A deficiency
0.000 0.374 0.626
E60 Dietary zinc deficiency
0.000 0.374 0.626
E59 Dietary selenium deficiency
0.000 0.374 0.626
E54 Ascorbic acid deficiency
0.000 0.374 0.626
E52 Niacin deficiency [pellagra]
0.000 0.374 0.626
K90.3 Pancreatic steatorrhoea
0.000 0.375 0.625
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.375 0.625
K90.1 Tropical sprue
0.000 0.375 0.625
E11.3 With ophthalmic complications
0.000 0.382 0.618
E51 Thiamine deficiency
0.000 0.382 0.618
E22.1 Hyperprolactinaemia
0.000 0.386 0.614
E56 Other vitamin deficiencies
0.000 0.388 0.612
E11.6 With other specified complications
0.000 0.396 0.604
E06 Thyroiditis
0.000 0.401 0.599
E13 Other specified diabetes mellitus
0.000 0.401 0.598
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.405 0.595
E58 Dietary calcium deficiency
0.000 0.406 0.594
E20.8 Other hypoparathyroidism
0.000 0.415 0.584
E20.1 Pseudohypoparathyroidism
0.000 0.415 0.584
E20.0 Idiopathic hypoparathyroidism
0.000 0.415 0.584
E53.1 Pyridoxine deficiency
0.000 0.416 0.584
E53.0 Riboflavin deficiency
0.000 0.416 0.584
E67 Other hyperalimentation
0.000 0.432 0.568
E68 Sequelae of hyperalimentation
0.000 0.432 0.568
E66.0 Obesity due to excess calories
0.000 0.433 0.567
L40.3 Pustulosis palmaris et plantaris
0.565 0.435 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.454 0.546
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.456 0.544
E22.8 Other hyperfunction of pituitary gland
0.000 0.456 0.544
E03.5 Myxoedema coma
0.298 0.461 0.240
E03.4 Atrophy of thyroid (acquired)
0.298 0.461 0.240
E03.3 Postinfectious hypothyroidism
0.298 0.461 0.240
E03.0 Congenital hypothyroidism with diffuse goitre
0.315 0.468 0.217
E24 Cushing's syndrome
0.000 0.468 0.532
E03.1 Congenital hypothyroidism without goitre
0.283 0.475 0.243
J33.0 Polyp of nasal cavity
0.000 0.477 0.523
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.513
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.513
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.513
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.513
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.513
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.513
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.513
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.513
E61 Deficiency of other nutrient elements
0.000 0.486 0.513
E11.2 With renal complications
0.000 0.490 0.510
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.314 0.491 0.196
E65 Localised adiposity
0.000 0.492 0.508
E55.9 Vitamin D deficiency, unspecified
0.000 0.492 0.508
E11.0 With coma
0.000 0.500 0.500
E30.9 Disorder of puberty, unspecified
0.000 0.500 0.500
E30.8 Other disorders of puberty
0.000 0.500 0.500
E30.1 Precocious puberty
0.000 0.500 0.500
E30.0 Delayed puberty
0.000 0.500 0.500
E31.9 Polyglandular dysfunction, unspecified
0.000 0.500 0.500
E31.8 Other polyglandular dysfunction
0.000 0.500 0.500
E31.1 Polyglandular hyperfunction
0.000 0.500 0.500
E31.0 Autoimmune polyglandular failure
0.000 0.500 0.500
E32.9 Disease of thymus, unspecified
0.000 0.500 0.500
E32.8 Other diseases of thymus
0.000 0.500 0.500
E32.1 Abscess of thymus
0.000 0.500 0.500
E32.0 Persistent hyperplasia of thymus
0.000 0.500 0.500
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.500 0.500
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.500 0.500
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.500 0.500
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.502 0.498
E45 Retarded development following protein-energy malnutrition
0.000 0.502 0.498
E43 Unspecified severe protein-energy malnutrition
0.000 0.502 0.498
E42 Marasmic kwashiorkor
0.000 0.502 0.498
E41 Nutritional marasmus
0.000 0.502 0.498
E40 Kwashiorkor
0.000 0.502 0.498
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.506 0.494
E26.9 Hyperaldosteronism, unspecified
0.000 0.508 0.491
I26 Pulmonary embolism
0.000 0.513 0.487
E66.1 Drug-induced obesity
0.000 0.516 0.484
E46 Unspecified protein-energy malnutrition
0.000 0.525 0.475
E55.0 Rickets, active
0.000 0.526 0.473
E06.9 Thyroiditis, unspecified
0.000 0.531 0.469
E13.3 With ophthalmic complications
0.000 0.531 0.469
E03.8 Other specified hypothyroidism
0.224 0.533 0.243
E26.8 Other hyperaldosteronism
0.000 0.536 0.464
E26.1 Secondary hyperaldosteronism
0.000 0.536 0.464
E07 Other disorders of thyroid
0.000 0.537 0.462
E28 Ovarian dysfunction
0.000 0.543 0.457
E25.9 Adrenogenital disorder, unspecified
0.000 0.544 0.455
E25.8 Other adrenogenital disorders
0.000 0.544 0.455
E50.9 Vitamin A deficiency, unspecified
0.000 0.551 0.449
E50.8 Other manifestations of vitamin A deficiency
0.000 0.551 0.449
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.551 0.449
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.551 0.449
E50.5 Vitamin A deficiency with night blindness
0.000 0.551 0.449
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.551 0.449
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.551 0.449
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.551 0.449
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.551 0.449
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.551 0.449
E63.9 Nutritional deficiency, unspecified
0.000 0.551 0.449
E63.8 Other specified nutritional deficiencies
0.000 0.551 0.449
E63.1 Imbalance of constituents of food intake
0.000 0.551 0.449
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.551 0.449
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.551 0.449
E64.8 Sequelae of other nutritional deficiencies
0.000 0.551 0.449
E64.3 Sequelae of rickets
0.000 0.551 0.449
E64.2 Sequelae of vitamin C deficiency
0.000 0.551 0.449
E64.1 Sequelae of vitamin A deficiency
0.000 0.551 0.449
E64.0 Sequelae of protein-energy malnutrition
0.000 0.551 0.449
E51.9 Thiamine deficiency, unspecified
0.000 0.557 0.443
E51.8 Other manifestations of thiamine deficiency
0.000 0.557 0.443
E51.1 Beriberi
0.000 0.557 0.443
E16.1 Other hypoglycaemia
0.001 0.561 0.439
E56.9 Vitamin deficiency, unspecified
0.000 0.561 0.439
E56.8 Deficiency of other vitamins
0.000 0.561 0.439
E56.0 Deficiency of vitamin E
0.000 0.561 0.439
E51.2 Wernicke's encephalopathy
0.000 0.564 0.435
J33 Nasal polyp
0.000 0.567 0.433
E06.4 Drug-induced thyroiditis
0.000 0.571 0.429
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.571 0.429
E06.0 Acute thyroiditis
0.000 0.571 0.429
E13.8 With unspecified complications
0.000 0.571 0.429
E13.7 With multiple complications
0.000 0.571 0.429
E13.6 With other specified complications
0.000 0.571 0.429
E13.5 With peripheral circulatory complications
0.000 0.571 0.429
E13.4 With neurological complications
0.000 0.571 0.429
E13.2 With renal complications
0.000 0.571 0.429
E13.1 With ketoacidosis
0.000 0.571 0.429
E13.0 With coma
0.000 0.571 0.429
E06.1 Subacute thyroiditis
0.000 0.573 0.427
E56.1 Deficiency of vitamin K
0.000 0.575 0.425
E27.9 Disorder of adrenal gland, unspecified
0.001 0.589 0.410
E67.8 Other specified hyperalimentation
0.000 0.593 0.407
E67.3 Hypervitaminosis D
0.000 0.593 0.407
E67.2 Megavitamin-B6 syndrome
0.000 0.593 0.407
E67.1 Hypercarotenaemia
0.000 0.593 0.407
E67.0 Hypervitaminosis A
0.000 0.593 0.407
J33.9 Nasal polyp, unspecified
0.000 0.597 0.403
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.607 0.393
E24.2 Drug-induced Cushing's syndrome
0.000 0.617 0.383
E24.8 Other Cushing's syndrome
0.000 0.618 0.381
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.618 0.381
E24.3 Ectopic ACTH syndrome
0.000 0.618 0.381
E24.1 Nelson's syndrome
0.000 0.618 0.381
E26.0 Primary hyperaldosteronism
0.000 0.626 0.374
I26.0 Pulmonary embolism with mention of acute cor pulmonale
0.000 0.628 0.372
E61.2 Magnesium deficiency
0.000 0.631 0.369
E06.3 Autoimmune thyroiditis
0.000 0.631 0.369
E61.9 Deficiency of nutrient element, unspecified
0.000 0.632 0.368
E61.8 Deficiency of other specified nutrient elements
0.000 0.632 0.368
E61.7 Deficiency of multiple nutrient elements
0.000 0.632 0.368
E61.6 Vanadium deficiency
0.000 0.632 0.368
E61.5 Molybdenum deficiency
0.000 0.632 0.368
E61.4 Chromium deficiency
0.000 0.632 0.368
E61.3 Manganese deficiency
0.000 0.632 0.368
E61.0 Copper deficiency
0.000 0.632 0.368
E24.0 Pituitary-dependent Cushing's disease
0.000 0.642 0.358
E44.1 Mild protein-energy malnutrition
0.000 0.643 0.357
E44.0 Moderate protein-energy malnutrition
0.000 0.643 0.357
J33.8 Other polyp of sinus
0.000 0.644 0.356
I21 Acute myocardial infarction
0.356 0.644 0.000
I25 Chronic ischaemic heart disease
0.354 0.646 0.000
I20-I25 Ischaemic heart diseases
0.352 0.648 0.000
I25.8 Other forms of chronic ischaemic heart disease
0.349 0.651 0.000
I21.9 Acute myocardial infarction, unspecified
0.346 0.654 0.000
I21.0 Acute transmural myocardial infarction of anterior wall
0.341 0.659 0.000
I25.5 Ischaemic cardiomyopathy
0.340 0.660 0.000
E07.1 Dyshormogenetic goitre
0.000 0.668 0.332
E07.0 Hypersecretion of calcitonin
0.000 0.668 0.332
I22 Subsequent myocardial infarction
0.328 0.672 0.000
E28.9 Ovarian dysfunction, unspecified
0.000 0.672 0.328
E28.8 Other ovarian dysfunction
0.000 0.672 0.328
E28.1 Androgen excess
0.000 0.672 0.328
E28.0 Oestrogen excess
0.000 0.672 0.328
L40-L45 Papulosquamous disorders
0.327 0.673 0.000
E06.5 Other chronic thyroiditis
0.001 0.674 0.325
I22.1 Subsequent myocardial infarction of inferior wall
0.324 0.676 0.000
D86.9 Sarcoidosis, unspecified
0.000 0.683 0.317
E07.8 Other specified disorders of thyroid
0.000 0.684 0.315
J33.1 Polypoid sinus degeneration
0.000 0.685 0.315
I21.2 Acute transmural myocardial infarction of other sites
0.315 0.685 0.000
D86 Sarcoidosis
0.000 0.696 0.304
D80-D89 Certain disorders involving the immune mechanism
0.000 0.702 0.298
E28.3 Primary ovarian failure
0.000 0.706 0.294
D69 Purpura and other haemorrhagic conditions
0.000 0.710 0.290
I25.3 Aneurysm of heart
0.290 0.710 0.000
D69.6 Thrombocytopenia, unspecified
0.000 0.710 0.290
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.711 0.289
I25.0 Atherosclerotic cardiovascular disease, so described
0.288 0.712 0.000
E14.9 Without complications
0.000 0.713 0.287
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.715 0.285
D69.9 Haemorrhagic condition, unspecified
0.000 0.723 0.277
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.728 0.272
D50-D53 Nutritional anaemias
0.000 0.728 0.272
D51 Vitamin B12 deficiency anaemia
0.000 0.729 0.271
E23 Hypofunction and other disorders of pituitary gland
0.000 0.730 0.269
I21.1 Acute transmural myocardial infarction of inferior wall
0.269 0.731 0.000
I23 Certain current complications following acute myocardial infarction
0.267 0.733 0.000
D86.8 Sarcoidosis of other and combined sites
0.000 0.744 0.256
E24.9 Cushing's syndrome, unspecified
0.000 0.744 0.255
I21.X Presumed acute myicardial infaction (unconfirmed)
0.255 0.745 0.000
E61.1 Iron deficiency
0.000 0.745 0.255
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.746 0.253
L42 Pityriasis rosea
0.251 0.748 0.000
I25.1 Atherosclerotic heart disease
0.249 0.751 0.000
I22.8 Subsequent myocardial infarction of other sites
0.248 0.752 0.000
I25.4 Coronary artery aneurysm
0.247 0.753 0.000
D80 Immunodeficiency with predominantly antibody defects
0.000 0.755 0.245
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.756 0.244
L44 Other papulosquamous disorders
0.242 0.758 0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.759 0.241
D86.1 Sarcoidosis of lymph nodes
0.000 0.760 0.240
I25.9 Chronic ischaemic heart disease, unspecified
0.239 0.761 0.000
D75 Other diseases of blood and blood-forming organs
0.000 0.762 0.238
I25.6 Silent myocardial ischaemia
0.237 0.763 0.000
L41 Parapsoriasis
0.235 0.765 0.000
L45 Papulosquamous disorders in diseases classified elsewhere
0.235 0.765 0.000
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.768 0.232
E04 Other non-toxic goitre
0.000 0.768 0.232
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.769 0.231
M45.X9 Ankylosing spondylitis (Site unspecified)
0.227 0.773 0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.776 0.224
E13.9 Without complications
0.000 0.777 0.222
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.779 0.221
D83 Common variable immunodeficiency
0.000 0.780 0.219
D53 Other nutritional anaemias
0.000 0.784 0.216
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.784 0.216
D69.4 Other primary thrombocytopenia
0.000 0.785 0.215
D69.2 Other nonthrombocytopenic purpura
0.000 0.785 0.215
D81 Combined immunodeficiencies
0.000 0.786 0.213
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.787 0.213
I22.0 Subsequent myocardial infarction of anterior wall
0.211 0.789 0.000
I20 Angina pectoris
0.211 0.789 0.000
D75.2 Essential thrombocytosis
0.000 0.790 0.210
D69.8 Other specified haemorrhagic conditions
0.000 0.792 0.208
I21.3 Acute transmural myocardial infarction of unspecified site
0.207 0.792 0.000
I23.8 Other current complications following acute myocardial infarction
0.206 0.794 0.000
D55-D59 Haemolytic anaemias
0.000 0.794 0.206
I20.0 Unstable angina
0.204 0.796 0.000
M45 Ankylosing spondylitis
0.203 0.797 0.000
D67 Hereditary factor IX deficiency
0.000 0.798 0.202
D82 Immunodeficiency associated with other major defects
0.000 0.798 0.201
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.801 0.199
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.806 0.194
D51.2 Transcobalamin II deficiency
0.000 0.806 0.194
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.806 0.194
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.807 0.193
E23.1 Drug-induced hypopituitarism
0.000 0.807 0.193
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.191 0.808 0.000
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.191 0.808 0.000
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.191 0.808 0.000
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.191 0.808 0.000
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.191 0.808 0.000
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.191 0.808 0.000
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.191 0.808 0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.810 0.190
D69.1 Qualitative platelet defects
0.000 0.810 0.190
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.810 0.190
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.811 0.189
D86.3 Sarcoidosis of skin
0.000 0.811 0.189
M45.X2 Ankylosing spondylitis (Cervical region)
0.189 0.811 0.000
D84 Other immunodeficiencies
0.000 0.812 0.188
D69.5 Secondary thrombocytopenia
0.000 0.812 0.187
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.816 0.183
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.817 0.183
I21.4 Acute subendocardial myocardial infarction
0.181 0.819 0.000
L44.0 Pityriasis rubra pilaris
0.180 0.819 0.000
D66 Hereditary factor VIII deficiency
0.000 0.823 0.177
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.823 0.177
I24 Other acute ischaemic heart diseases
0.176 0.824 0.000
D53.9 Nutritional anaemia, unspecified
0.000 0.824 0.176
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.824 0.176
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.824 0.176
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.824 0.176
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.824 0.176
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.824 0.176
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.825 0.175
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.175 0.825 0.000
D74 Methaemoglobinaemia
0.000 0.825 0.175
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.825 0.175
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.825 0.175
L44.9 Papulosquamous disorder, unspecified
0.173 0.826 0.000
L44.8 Other specified papulosquamous disorders
0.173 0.826 0.000
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.173 0.826 0.000
L44.3 Lichen ruber moniliformis
0.173 0.826 0.000
L44.2 Lichen striatus
0.173 0.826 0.000
L44.1 Lichen nitidus
0.173 0.826 0.000
D89.1 Cryoglobulinaemia
0.000 0.827 0.173
D89.3 Immune reconstitution syndrome
0.000 0.827 0.173
E23.6 Other disorders of pituitary gland
0.000 0.827 0.172
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.828 0.172
L41.9 Parapsoriasis, unspecified
0.168 0.831 0.000
L41.8 Other parapsoriasis
0.168 0.831 0.000
L41.5 Retiform parapsoriasis
0.168 0.831 0.000
L41.4 Large plaque parapsoriasis
0.168 0.831 0.000
L41.3 Small plaque parapsoriasis
0.168 0.831 0.000
L41.2 Lymphomatoid papulosis
0.168 0.831 0.000
L41.1 Pityriasis lichenoides chronica
0.168 0.831 0.000
L41.0 Pityriasis lichenoides et varioliformis acuta
0.168 0.831 0.000
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.832 0.168
E04.0 Non-toxic diffuse goitre
0.000 0.833 0.167
E04.8 Other specified non-toxic goitre
0.000 0.834 0.166
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.000 0.835 0.165
E28.2 Polycystic ovarian syndrome
0.000 0.836 0.164
D83.9 Common variable immunodeficiency, unspecified
0.000 0.836 0.163
E04.9 Non-toxic goitre, unspecified
0.000 0.838 0.162
D70 Agranulocytosis
0.000 0.841 0.159
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.842 0.158
D59 Acquired haemolytic anaemia
0.000 0.842 0.158
D83.8 Other common variable immunodeficiencies
0.000 0.842 0.157
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.842 0.157
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.842 0.157
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.842 0.157
I24.8 Other forms of acute ischaemic heart disease
0.158 0.842 0.000
D53.8 Other specified nutritional anaemias
0.000 0.845 0.155
D53.2 Scorbutic anaemia
0.000 0.845 0.155
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.845 0.155
D53.0 Protein deficiency anaemia
0.000 0.845 0.155
D75.0 Familial erythrocytosis
0.000 0.846 0.154
D81.9 Combined immunodeficiency, unspecified
0.000 0.847 0.153
D81.8 Other combined immunodeficiencies
0.000 0.847 0.153
D81.7 Major histocompatibility complex class II deficiency
0.000 0.847 0.153
D81.6 Major histocompatibility complex class I deficiency
0.000 0.847 0.153
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.847 0.153
D81.4 Nezelof's syndrome
0.000 0.847 0.153
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.847 0.153
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.847 0.153
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.847 0.153
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.847 0.153
E23.2 Diabetes insipidus
0.000 0.847 0.153
E21.4 Other specified disorders of parathyroid gland
0.000 0.847 0.153
D76.3 Other histiocytosis syndromes
0.000 0.848 0.152
M45.X6 Ankylosing spondylitis (Lumbar region)
0.150 0.849 0.000
E21.2 Other hyperparathyroidism
0.000 0.851 0.149
D55 Anaemia due to enzyme disorders
0.000 0.852 0.148
L43 Lichen planus
0.147 0.853 0.000
D58 Other hereditary haemolytic anaemias
0.000 0.853 0.147
D57 Sickle-cell disorders
0.000 0.853 0.146
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.854 0.146
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.145 0.854 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.145 0.854 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.145 0.854 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.145 0.854 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.145 0.854 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.145 0.854 0.000
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.855 0.144
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.855 0.144
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.855 0.144
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.855 0.144
D82.2 Immunodeficiency with short-limbed stature
0.000 0.855 0.144
D82.0 Wiskott-Aldrich syndrome
0.000 0.855 0.144
D75.1 Secondary polycythaemia
0.000 0.856 0.144
E23.7 Disorder of pituitary gland, unspecified
0.000 0.858 0.142
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.858 0.142
D84.1 Defects in the complement system
0.000 0.860 0.140
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.861 0.139
D56 Thalassaemia
0.000 0.861 0.138
D84.8 Other specified immunodeficiencies
0.000 0.863 0.137
D76.2 Haemophagocytic syndrome, infection-associated
0.000 0.863 0.137
D76.1 Haemophagocytic lymphohistiocytosis
0.000 0.863 0.137
D76.0 Langerhans' cell histiocytosis, not elsewhere classified
0.000 0.863 0.137
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.865 0.135
D82.1 Di George's syndrome
0.000 0.867 0.132
D52 Folate deficiency anaemia
0.000 0.867 0.132
D69.0 Allergic purpura
0.000 0.872 0.127
D86.0 Sarcoidosis of lung
0.000 0.874 0.126
D74.9 Methaemoglobinaemia, unspecified
0.000 0.874 0.126
D74.8 Other methaemoglobinaemias
0.000 0.874 0.126
D74.0 Congenital methaemoglobinaemia
0.000 0.874 0.126
D72 Other disorders of white blood cells
0.000 0.875 0.125
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.878 0.122
E07.9 Disorder of thyroid, unspecified
0.000 0.879 0.120
I20.1 Angina pectoris with documented spasm
0.120 0.880 0.000
I27 Other pulmonary heart diseases
0.000 0.880 0.120
E23.0 Hypopituitarism
0.000 0.886 0.114
D59.8 Other acquired haemolytic anaemias
0.000 0.887 0.113
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.887 0.113
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.887 0.113
D59.3 Haemolytic-uraemic syndrome
0.000 0.887 0.113
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.887 0.113
D58.0 Hereditary spherocytosis
0.000 0.888 0.112

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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