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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs28371206
log Bayes Factor = 101.509
Chromosome 6   position 32,636,696  (GRCh37) Explore rs28371206 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E10.1 With ketoacidosis
0.000 0.000 1.000
J45.9 Asthma, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
0.000 0.000 1.000
N48 Other disorders of penis
1.000 0.000 0.000
N47 Redundant prepuce, phimosis and paraphimosis
1.000 0.000 0.000
E16.2 Hypoglycaemia, unspecified
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
N48.6 Balanitis xerotica obliterans
1.000 0.000 0.000
E10.4 With neurological complications
0.000 0.001 0.999
E16 Other disorders of pancreatic internal secretion
0.000 0.002 0.998
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.003 0.997
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.003 0.997
N40-N51 Diseases of male genital organs
0.997 0.003 0.000
H36.0 Diabetic retinopathy
0.000 0.003 0.997
E10.2 With renal complications
0.000 0.006 0.994
E14 Unspecified diabetes mellitus
0.000 0.007 0.993
N48.1 Balanoposthitis
0.990 0.010 0.000
N48.0 Leukoplakia of penis
0.982 0.018 0.000
E10.5 With peripheral circulatory complications
0.000 0.025 0.975
E14.3 With ophthalmic complications
0.000 0.036 0.964
D07.1 Vulva
0.946 0.054 0.000
D07 Carcinoma in situ of other and unspecified genital organs
0.942 0.058 0.000
D00-D09 In situ neoplasms
0.938 0.062 0.000
D06 Carcinoma in situ of cervix uteri
0.930 0.070 0.000
D06.9 Cervix, unspecified
0.918 0.082 0.000
N45 Orchitis and epididymitis
0.914 0.086 0.000
E14.9 Without complications
0.000 0.108 0.892
L90.0 Lichen sclerosus et atrophicus
0.883 0.117 0.000
D04 Carcinoma in situ of skin
0.877 0.123 0.000
D07.4 Penis
0.872 0.128 0.000
N48.2 Other inflammatory disorders of penis
0.862 0.138 0.000
N48.8 Other specified disorders of penis
0.859 0.141 0.000
N48.5 Ulcer of penis
0.855 0.145 0.000
E10.0 With coma
0.000 0.152 0.848
N44 Torsion of testis
0.845 0.155 0.000
E10.8 With unspecified complications
0.000 0.160 0.840
N90 Other noninflammatory disorders of vulva and perineum
0.834 0.166 0.000
N90.4 Leukoplakia of vulva
0.834 0.166 0.000
E50-E64 Other nutritional deficiencies
0.000 0.173 0.827
N48.9 Disorder of penis, unspecified
0.823 0.177 0.000
D03 Melanoma in situ
0.823 0.177 0.000
D04.7 Skin of lower limb, including hip
0.819 0.181 0.000
N90.7 Vulvar cyst
0.807 0.193 0.000
N45.9 Orchitis, epididymitis and epididymo-orchitis without abscess
0.799 0.201 0.000
E00-E07 Disorders of thyroid gland
0.006 0.208 0.786
D01 Carcinoma in situ of other and unspecified digestive organs
0.792 0.208 0.000
E14.5 With peripheral circulatory complications
0.000 0.212 0.788
N90.8 Other specified noninflammatory disorders of vulva and perineum
0.785 0.215 0.000
D04.9 Skin, unspecified
0.784 0.216 0.000
E55 Vitamin D deficiency
0.000 0.218 0.782
N45.0 Orchitis, epididymitis and epididymo-orchitis with abscess
0.778 0.222 0.000
D03.2 Melanoma in situ of ear and external auricular canal
0.777 0.223 0.000
E14.6 With other specified complications
0.000 0.225 0.775
N48.4 Impotence of organic origin
0.772 0.228 0.000
E14.8 With unspecified complications
0.000 0.230 0.770
E10.6 With other specified complications
0.000 0.238 0.762
D02 Carcinoma in situ of middle ear and respiratory system
0.760 0.240 0.000
E40-E46 Malnutrition
0.000 0.245 0.755
E55.9 Vitamin D deficiency, unspecified
0.000 0.250 0.750
N90.3 Dysplasia of vulva, unspecified
0.748 0.252 0.000
N90.1 Moderate vulvar dysplasia
0.741 0.259 0.000
D06.0 Endocervix
0.740 0.260 0.000
E20-E35 Disorders of other endocrine glands
0.000 0.260 0.740
N90.9 Noninflammatory disorder of vulva and perineum, unspecified
0.738 0.262 0.000
D06.1 Exocervix
0.738 0.262 0.000
E14.2 Withrenal complications
0.000 0.268 0.732
E14.1 With ketoacidosis
0.000 0.275 0.725
D04.4 Skin of scalp and neck
0.720 0.280 0.000
N48.3 Priapism
0.717 0.282 0.000
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.285 0.715
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.285 0.715
E16.4 Abnormal secretion of gastrin
0.000 0.285 0.715
E16.3 Increased secretion of glucagon
0.000 0.285 0.715
E15 Nondiabetic hypoglycaemic coma
0.000 0.285 0.715
E14.7 With multiple complications
0.000 0.288 0.712
E14.0 With coma
0.000 0.288 0.712
E03 Other hypothyroidism
0.513 0.291 0.196
D04.3 Skin of other and unspecified parts of face
0.709 0.291 0.000
D09 Carcinoma in situ of other and unspecified sites
0.709 0.291 0.000
N51 Disorders of male genital organs in diseases classified elsewhere
0.694 0.306 0.000
E27 Other disorders of adrenal gland
0.000 0.307 0.693
D01.3 Anus and anal canal
0.692 0.308 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.315 0.684
N42 Other disorders of prostate
0.683 0.317 0.000
E27.1 Primary adrenocortical insufficiency
0.000 0.322 0.678
D07.6 Other and unspecified male genital organs
0.675 0.325 0.000
D07.3 Other and unspecified female genital organs
0.675 0.325 0.000
D07.0 Endometrium
0.675 0.325 0.000
E14.4 With neurological complications
0.000 0.325 0.674
D07.2 Vagina
0.671 0.329 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.001 0.330 0.669
D06.7 Other parts of cervix
0.666 0.333 0.000
D00 Carcinoma in situ of oral cavity, oesophagus and stomach
0.661 0.339 0.000
D03.5 Melanoma in situ of trunk
0.657 0.343 0.000
D03.8 Melanoma in situ of other sites
0.654 0.345 0.000
N90.0 Mild vulvar dysplasia
0.645 0.355 0.000
E34 Other endocrine disorders
0.000 0.358 0.642
N41 Inflammatory diseases of prostate
0.636 0.364 0.000
N90.6 Hypertrophy of vulva
0.629 0.371 0.000
D04.8 Skin of other sites
0.629 0.371 0.000
D04.0 Skin of lip
0.629 0.371 0.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.371 0.629
E06 Thyroiditis
0.002 0.374 0.623
E27.8 Other specified disorders of adrenal gland
0.000 0.377 0.623
J45 Asthma
0.620 0.380 0.000
D09.1 Other and unspecified urinary organs
0.615 0.385 0.000
D02.0 Larynx
0.611 0.389 0.000
N49 Inflammatory disorders of male genital organs, not elsewhere classified
0.606 0.394 0.000
L90 Atrophic disorders of skin
0.605 0.395 0.000
N90.2 Severe vulvar dysplasia, not elsewhere classified
0.598 0.402 0.000
N42.9 Disorder of prostate, unspecified
0.595 0.405 0.000
D04.1 Skin of eyelid, including canthus
0.593 0.407 0.000
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.407 0.593
E63 Other nutritional deficiencies
0.000 0.407 0.593
E51 Thiamine deficiency
0.000 0.407 0.593
E50 Vitamin A deficiency
0.000 0.407 0.593
E60 Dietary zinc deficiency
0.000 0.407 0.593
E59 Dietary selenium deficiency
0.000 0.407 0.593
E54 Ascorbic acid deficiency
0.000 0.407 0.593
E52 Niacin deficiency [pellagra]
0.000 0.407 0.593
D03.9 Melanoma in situ, unspecified
0.590 0.410 0.000
D03.1 Melanoma in situ of eyelid, including canthus
0.590 0.410 0.000
D03.0 Melanoma in situ of lip
0.590 0.410 0.000
E46 Unspecified protein-energy malnutrition
0.000 0.419 0.581
E02 Subclinical iodine-deficiency hypothyroidism
0.004 0.420 0.575
D02.2 Bronchus and lung
0.577 0.423 0.000
D03.7 Melanoma in situ of lower limb, including hip
0.576 0.424 0.000
D04.5 Skin of trunk
0.570 0.430 0.000
N46 Male infertility
0.569 0.431 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.004 0.432 0.564
E00 Congenital iodine-deficiency syndrome
0.004 0.432 0.564
D01.9 Digestive organ, unspecified
0.568 0.432 0.000
D01.7 Other specified digestive organs
0.568 0.432 0.000
D01.5 Liver, gallbladder and bile ducts
0.568 0.432 0.000
D01.4 Other and unspecified parts of intestine
0.568 0.432 0.000
D01.2 Rectum
0.568 0.432 0.000
D01.1 Rectosigmoid junction
0.568 0.432 0.000
E07 Other disorders of thyroid
0.003 0.436 0.560
E28 Ovarian dysfunction
0.000 0.438 0.562
E55.0 Rickets, active
0.000 0.439 0.561
D01.0 Colon
0.557 0.443 0.000
E22 Hyperfunction of pituitary gland
0.000 0.446 0.554
E16.1 Other hypoglycaemia
0.000 0.446 0.554
L90.5 Scar conditions and fibrosis of skin
0.551 0.449 0.000
E56 Other vitamin deficiencies
0.000 0.454 0.546
D02.4 Respiratory system, unspecified
0.545 0.455 0.000
D02.3 Other parts of respiratory system
0.545 0.455 0.000
D02.1 Trachea
0.545 0.455 0.000
D03.6 Melanoma in situ of upper limb, including shoulder
0.544 0.456 0.000
E53 Deficiency of other B group vitamins
0.000 0.458 0.542
E23 Hypofunction and other disorders of pituitary gland
0.000 0.458 0.542
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.459 0.541
E45 Retarded development following protein-energy malnutrition
0.000 0.459 0.541
E43 Unspecified severe protein-energy malnutrition
0.000 0.459 0.541
E42 Marasmic kwashiorkor
0.000 0.459 0.541
E41 Nutritional marasmus
0.000 0.459 0.541
E40 Kwashiorkor
0.000 0.459 0.541
N30.2 Other chronic cystitis
0.532 0.468 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.470 0.530
E32 Diseases of thymus
0.000 0.470 0.530
E31 Polyglandular dysfunction
0.000 0.470 0.530
E30 Disorders of puberty, not elsewhere classified
0.000 0.470 0.530
N30 Cystitis
0.529 0.471 0.000
E58 Dietary calcium deficiency
0.000 0.474 0.525
E34.8 Other specified endocrine disorders
0.000 0.478 0.522
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
N30.1 Interstitial cystitis (chronic)
0.512 0.488 0.000
E34.0 Carcinoid syndrome
0.000 0.489 0.511
E05.9 Thyrotoxicosis, unspecified
0.000 0.490 0.510
N41.0 Acute prostatitis
0.510 0.490 0.000
E03.5 Myxoedema coma
0.368 0.492 0.140
E03.4 Atrophy of thyroid (acquired)
0.368 0.492 0.140
E03.3 Postinfectious hypothyroidism
0.368 0.492 0.140
D09.9 Carcinoma in situ, unspecified
0.508 0.492 0.000
D09.7 Carcinoma in situ of other specified sites
0.508 0.492 0.000
D09.3 Thyroid and other endocrine glands
0.508 0.492 0.000
D09.2 Eye
0.508 0.492 0.000
J45.0 Predominantly allergic asthma
0.506 0.494 0.000
E03.1 Congenital hypothyroidism without goitre
0.368 0.497 0.135
E07.8 Other specified disorders of thyroid
0.001 0.499 0.500
N42.2 Atrophy of prostate
0.498 0.502 0.000
N51.8 Other disorders of male genital organs in diseases classified elsewhere
0.497 0.502 0.000
N51.1 Disorders of testis and epididymis in diseases classified elsewhere
0.497 0.502 0.000
N51.0 Disorders of prostate in diseases classified elsewhere
0.497 0.502 0.000
N30.0 Acute cystitis
0.497 0.503 0.000
E27.5 Adrenomedullary hyperfunction
0.000 0.503 0.497
E27.0 Other adrenocortical overactivity
0.000 0.503 0.497
E03.0 Congenital hypothyroidism with diffuse goitre
0.356 0.504 0.141
E06.9 Thyroiditis, unspecified
0.001 0.506 0.493
E34.9 Endocrine disorder, unspecified
0.000 0.507 0.493
E06.3 Autoimmune thyroiditis
0.001 0.507 0.492
E61 Deficiency of other nutrient elements
0.000 0.507 0.493
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.367 0.507 0.125
E26 Hyperaldosteronism
0.000 0.508 0.492
E20 Hypoparathyroidism
0.000 0.508 0.492
N42.3 Dysplasia of prostate
0.490 0.510 0.000
D04.2 Skin of ear and external auricular canal
0.488 0.512 0.000
E03.8 Other specified hypothyroidism
0.378 0.514 0.108
D00.0 Lip, oral cavity and pharynx
0.484 0.516 0.000
E27.9 Disorder of adrenal gland, unspecified
0.000 0.518 0.482
E04 Other non-toxic goitre
0.001 0.519 0.481
E05.5 Thyroid crisis or storm
0.001 0.519 0.480
E05.4 Thyrotoxicosis factitia
0.001 0.519 0.480
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.001 0.519 0.480
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.001 0.519 0.480
J45.8 Mixed asthma
0.478 0.522 0.000
E25 Adrenogenital disorders
0.000 0.523 0.477
N51.2 Balanitis in diseases classified elsewhere
0.477 0.523 0.000
J45.1 Nonallergic asthma
0.475 0.525 0.000
D00.2 Stomach
0.474 0.526 0.000
E23.7 Disorder of pituitary gland, unspecified
0.000 0.529 0.471
E29 Testicular dysfunction
0.000 0.531 0.469
E13 Other specified diabetes mellitus
0.001 0.532 0.468
N30.4 Irradiation cystitis
0.464 0.536 0.000
N42.1 Congestion and haemorrhage of prostate
0.463 0.537 0.000
N41.1 Chronic prostatitis
0.463 0.537 0.000
N42.8 Other specified disorders of prostate
0.461 0.539 0.000
E34.5 Androgen resistance syndrome
0.000 0.540 0.460
E34.4 Constitutional tall stature
0.000 0.540 0.460
E34.3 Short stature, not elsewhere classified
0.000 0.540 0.460
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.540 0.460
E34.1 Other hypersecretion of intestinal hormones
0.000 0.540 0.460
D03.4 Melanoma in situ of scalp and neck
0.457 0.543 0.000
N41.3 Prostatocystitis
0.456 0.544 0.000
N41.2 Abscess of prostate
0.456 0.544 0.000
E22.0 Acromegaly and pituitary gigantism
0.000 0.545 0.455
N30.8 Other cystitis
0.454 0.546 0.000
D00.1 Oesophagus
0.451 0.548 0.000
E06.4 Drug-induced thyroiditis
0.002 0.551 0.447
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.002 0.551 0.447
E06.1 Subacute thyroiditis
0.002 0.551 0.447
E06.0 Acute thyroiditis
0.002 0.551 0.447
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.551 0.448
H36 Retinal disorders in diseases classified elsewhere
0.000 0.560 0.440
N49.9 Inflammatory disorder of unspecified male genital organ
0.434 0.565 0.000
N49.1 Inflammatory disorders of spermatic cord, tunica vaginalis and vas deferens
0.434 0.565 0.000
N49.0 Inflammatory disorders of seminal vesicle
0.434 0.565 0.000
L90.9 Atrophic disorder of skin, unspecified
0.434 0.566 0.000
L90.6 Striae atrophicae
0.434 0.566 0.000
L90.4 Acrodermatitis chronica atrophicans
0.434 0.566 0.000
L90.3 Atrophoderma of Pasini and Pierini
0.434 0.566 0.000
L90.2 Anetoderma of Jadassohn-Pellizzari
0.434 0.566 0.000
L90.1 Anetoderma of Schweninger-Buzzi
0.434 0.566 0.000
E04.0 Non-toxic diffuse goitre
0.000 0.566 0.434
N41.8 Other inflammatory diseases of prostate
0.433 0.567 0.000
N30.3 Trigonitis
0.431 0.569 0.000
E22.1 Hyperprolactinaemia
0.000 0.569 0.431
L90.8 Other atrophic disorders of skin
0.427 0.573 0.000
E50.9 Vitamin A deficiency, unspecified
0.000 0.574 0.425
E50.8 Other manifestations of vitamin A deficiency
0.000 0.574 0.425
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.574 0.425
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.574 0.425
E50.5 Vitamin A deficiency with night blindness
0.000 0.574 0.425
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.574 0.425
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.574 0.425
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.574 0.425
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.574 0.425
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.574 0.425
E51.9 Thiamine deficiency, unspecified
0.000 0.574 0.425
E51.8 Other manifestations of thiamine deficiency
0.000 0.574 0.425
E51.2 Wernicke's encephalopathy
0.000 0.574 0.425
E51.1 Beriberi
0.000 0.574 0.425
E63.9 Nutritional deficiency, unspecified
0.000 0.574 0.425
E63.8 Other specified nutritional deficiencies
0.000 0.574 0.425
E63.1 Imbalance of constituents of food intake
0.000 0.574 0.425
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.574 0.425
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.574 0.425
E64.8 Sequelae of other nutritional deficiencies
0.000 0.574 0.425
E64.3 Sequelae of rickets
0.000 0.574 0.425
E64.2 Sequelae of vitamin C deficiency
0.000 0.574 0.425
E64.1 Sequelae of vitamin A deficiency
0.000 0.574 0.425
E64.0 Sequelae of protein-energy malnutrition
0.000 0.574 0.425
E28.2 Polycystic ovarian syndrome
0.000 0.575 0.425
E65-E68 Obesity and other hyperalimentation
0.000 0.576 0.424
K90 Intestinal malabsorption
0.000 0.578 0.422
E53.9 Vitamin B deficiency, unspecified
0.000 0.581 0.418
E23.6 Other disorders of pituitary gland
0.000 0.583 0.417
E28.3 Primary ovarian failure
0.000 0.586 0.414
E06.5 Other chronic thyroiditis
0.002 0.586 0.412
D03.3 Melanoma in situ of other and unspecified parts of face
0.413 0.587 0.000
N49.8 Inflammatory disorders of other specified male genital organs
0.408 0.591 0.000
E70-E90 Metabolic disorders
0.000 0.592 0.408
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.003 0.593 0.404
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.003 0.593 0.404
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.003 0.593 0.404
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.003 0.593 0.404
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.003 0.593 0.404
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.003 0.593 0.404
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.003 0.593 0.404
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.003 0.593 0.404
E07.1 Dyshormogenetic goitre
0.002 0.596 0.402
E07.0 Hypersecretion of calcitonin
0.002 0.596 0.402
E83 Disorders of mineral metabolism
0.000 0.597 0.403
E28.9 Ovarian dysfunction, unspecified
0.000 0.597 0.403
E28.8 Other ovarian dysfunction
0.000 0.597 0.403
E28.1 Androgen excess
0.000 0.597 0.403
E28.0 Oestrogen excess
0.000 0.597 0.403
E83.1 Disorders of iron metabolism
0.000 0.597 0.403
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.603 0.397
E22.8 Other hyperfunction of pituitary gland
0.000 0.603 0.397
N43 Hydrocele and spermatocele
0.396 0.604 0.000
E56.9 Vitamin deficiency, unspecified
0.000 0.608 0.392
E56.8 Deficiency of other vitamins
0.000 0.608 0.392
E56.0 Deficiency of vitamin E
0.000 0.608 0.392
E53.1 Pyridoxine deficiency
0.000 0.611 0.389
E53.0 Riboflavin deficiency
0.000 0.611 0.389
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.611 0.388
E23.1 Drug-induced hypopituitarism
0.000 0.611 0.388
E44.1 Mild protein-energy malnutrition
0.000 0.612 0.388
E44.0 Moderate protein-energy malnutrition
0.000 0.612 0.388
E30.9 Disorder of puberty, unspecified
0.000 0.620 0.380
E30.8 Other disorders of puberty
0.000 0.620 0.380
E30.1 Precocious puberty
0.000 0.620 0.380
E30.0 Delayed puberty
0.000 0.620 0.380
E31.9 Polyglandular dysfunction, unspecified
0.000 0.620 0.380
E31.8 Other polyglandular dysfunction
0.000 0.620 0.380
E31.1 Polyglandular hyperfunction
0.000 0.620 0.380
E31.0 Autoimmune polyglandular failure
0.000 0.620 0.380
E32.9 Disease of thymus, unspecified
0.000 0.620 0.380
E32.8 Other diseases of thymus
0.000 0.620 0.380
E32.1 Abscess of thymus
0.000 0.620 0.380
E32.0 Persistent hyperplasia of thymus
0.000 0.620 0.380
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.620 0.380
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.620 0.380
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.620 0.380
E05.8 Other thyrotoxicosis
0.001 0.622 0.377
E27.2 Addisonian crisis
0.000 0.624 0.376
E61.2 Magnesium deficiency
0.000 0.631 0.369
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.001 0.636 0.362
E83.4 Disorders of magnesium metabolism
0.000 0.638 0.362
N49.2 Inflammatory disorders of scrotum
0.362 0.638 0.000
D04.6 Skin of upper limb, including shoulder
0.361 0.639 0.000
D09.0 Bladder
0.356 0.644 0.000
E61.9 Deficiency of nutrient element, unspecified
0.000 0.646 0.353
E61.8 Deficiency of other specified nutrient elements
0.000 0.646 0.353
E61.7 Deficiency of multiple nutrient elements
0.000 0.646 0.353
E61.6 Vanadium deficiency
0.000 0.646 0.353
E61.5 Molybdenum deficiency
0.000 0.646 0.353
E61.4 Chromium deficiency
0.000 0.646 0.353
E61.3 Manganese deficiency
0.000 0.646 0.353
E61.0 Copper deficiency
0.000 0.646 0.353
E26.9 Hyperaldosteronism, unspecified
0.000 0.647 0.353
E26.8 Other hyperaldosteronism
0.000 0.647 0.353
E26.1 Secondary hyperaldosteronism
0.000 0.647 0.353
E20.8 Other hypoparathyroidism
0.000 0.647 0.353
E20.1 Pseudohypoparathyroidism
0.000 0.647 0.353
E20.0 Idiopathic hypoparathyroidism
0.000 0.647 0.353
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.647 0.352
E23.0 Hypopituitarism
0.000 0.654 0.346
E04.8 Other specified non-toxic goitre
0.001 0.655 0.345
E56.1 Deficiency of vitamin K
0.000 0.655 0.345
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.657 0.343
E25.9 Adrenogenital disorder, unspecified
0.000 0.658 0.342
E25.8 Other adrenogenital disorders
0.000 0.658 0.342
G37 Other demyelinating diseases of central nervous system
0.000 0.663 0.337
E29.8 Other testicular dysfunction
0.000 0.663 0.336
E29.0 Testicular hyperfunction
0.000 0.663 0.336
E13.8 With unspecified complications
0.001 0.664 0.335
E13.7 With multiple complications
0.001 0.664 0.335
E13.6 With other specified complications
0.001 0.664 0.335
E13.5 With peripheral circulatory complications
0.001 0.664 0.335
E13.4 With neurological complications
0.001 0.664 0.335
E13.2 With renal complications
0.001 0.664 0.335
E13.1 With ketoacidosis
0.001 0.664 0.335
E13.0 With coma
0.001 0.664 0.335
E87 Other disorders of fluid, electrolyte and acid-base balance
0.000 0.667 0.333
N90.5 Atrophy of vulva
0.325 0.674 0.000
G36 Other acute disseminated demyelination
0.000 0.678 0.322
E87.7 Fluid overload
0.000 0.681 0.319
E29.1 Testicular hypofunction
0.000 0.683 0.317
E04.9 Non-toxic goitre, unspecified
0.000 0.683 0.317
E13.3 With ophthalmic complications
0.001 0.684 0.315
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.684 0.316
E26.0 Primary hyperaldosteronism
0.000 0.685 0.314
E87.1 Hypo-osmolality and hyponatraemia
0.000 0.686 0.314
E20.9 Hypoparathyroidism, unspecified
0.000 0.686 0.314
E79 Disorders of purine and pyrimidine metabolism
0.000 0.695 0.305
E67 Other hyperalimentation
0.000 0.696 0.304
E68 Sequelae of hyperalimentation
0.000 0.696 0.304
K90.3 Pancreatic steatorrhoea
0.000 0.697 0.303
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.697 0.303
K90.1 Tropical sprue
0.000 0.697 0.303
N43.2 Other hydrocele
0.303 0.697 0.000
K90.8 Other intestinal malabsorption
0.000 0.700 0.300
E29.9 Testicular dysfunction, unspecified
0.000 0.700 0.300
E84 Cystic fibrosis
0.000 0.701 0.299
E73 Lactose intolerance
0.000 0.702 0.298
N41.9 Inflammatory disease of prostate, unspecified
0.297 0.703 0.000
E04.2 Non-toxic multinodular goitre
0.000 0.704 0.296
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.705 0.295
E77 Disorders of glycoprotein metabolism
0.000 0.708 0.292
E76 Disorders of glycosaminoglycan metabolism
0.000 0.708 0.292
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.708 0.292
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.708 0.292
N42.0 Calculus of prostate
0.292 0.708 0.000
N43.1 Infected hydrocele
0.290 0.710 0.000
E53.8 Deficiency of other specified B group vitamins
0.000 0.710 0.290
E83.8 Other disorders of mineral metabolism
0.000 0.711 0.289
E83.2 Disorders of zinc metabolism
0.000 0.711 0.289
E83.0 Disorders of copper metabolism
0.000 0.711 0.289
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.711 0.289
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.713 0.287
N43.0 Encysted hydrocele
0.284 0.716 0.000
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.723 0.276
E88 Other metabolic disorders
0.000 0.724 0.276
E72 Other disorders of amino-acid metabolism
0.000 0.724 0.275
E24 Cushing's syndrome
0.001 0.730 0.269
E70 Disorders of aromatic amino-acid metabolism
0.000 0.736 0.264
E11 Non-insulin-dependent diabetes mellitus
0.000 0.738 0.262
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.738 0.262
N30.9 Cystitis, unspecified
0.255 0.745 0.000
E65 Localised adiposity
0.000 0.745 0.255
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.745 0.255
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.746 0.254
C21.0 Anus, unspecified
0.251 0.749 0.000
C21.1 Anal canal
0.246 0.754 0.000
E23.2 Diabetes insipidus
0.000 0.754 0.246
E74 Other disorders of carbohydrate metabolism
0.000 0.754 0.246
G37.9 Demyelinating disease of central nervous system, unspecified
0.000 0.754 0.246
C21 Malignant neoplasm of anus and anal canal
0.244 0.756 0.000
G37.5 Concentric sclerosis [Balo]
0.000 0.758 0.241
G37.4 Subacute necrotising myelitis
0.000 0.758 0.241
G37.2 Central pontine myelinolysis
0.000 0.758 0.241
G37.1 Central demyelination of corpus callosum
0.000 0.758 0.241
G37.0 Diffuse sclerosis
0.000 0.758 0.241
E87.4 Mixed disorder of acid-base balance
0.000 0.761 0.239
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.763 0.236
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.769 0.231
G36.9 Acute disseminated demyelination, unspecified
0.000 0.769 0.231
G36.8 Other specified acute disseminated demyelination
0.000 0.769 0.231
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.000 0.769 0.231
G36.0 Neuromyelitis optica [Devic]
0.000 0.769 0.231
E83.5 Disorders of calcium metabolism
0.000 0.769 0.231
G37.8 Other specified demyelinating diseases of central nervous system
0.000 0.770 0.230
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.000 0.771 0.229
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.775 0.225
E61.1 Iron deficiency
0.000 0.777 0.223
N43.4 Spermatocele
0.222 0.777 0.000
E89.0 Postprocedural hypothyroidism
0.000 0.778 0.222
E87.5 Hyperkalaemia
0.000 0.779 0.221
E84.9 Cystic fibrosis, unspecified
0.000 0.779 0.220
E73.9 Lactose intolerance, unspecified
0.000 0.780 0.219
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.781 0.218
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.781 0.218
E79.1 Lesch-Nyhan syndrome
0.000 0.781 0.218
E67.8 Other specified hyperalimentation
0.000 0.782 0.218
E67.3 Hypervitaminosis D
0.000 0.782 0.218
E67.2 Megavitamin-B6 syndrome
0.000 0.782 0.218
E67.1 Hypercarotenaemia
0.000 0.782 0.218
E67.0 Hypervitaminosis A
0.000 0.782 0.218
E11.3 With ophthalmic complications
0.000 0.785 0.215
E84.8 Cystic fibrosis with other manifestations
0.000 0.786 0.214
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.786 0.214
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.786 0.214
E73.8 Other lactose intolerance
0.000 0.786 0.214
E73.1 Secondary lactase deficiency
0.000 0.786 0.214
E73.0 Congenital lactase deficiency
0.000 0.786 0.214
E71.3 Disorders of fatty-acid metabolism
0.000 0.790 0.210
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.790 0.210
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.790 0.210
E71.0 Maple-syrup-urine disease
0.000 0.790 0.210
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.790 0.210
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.790 0.210
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.790 0.210
E76.2 Other mucopolysaccharidoses
0.000 0.790 0.210
E76.1 Mucopolysaccharidosis, type II
0.000 0.790 0.210
E76.0 Mucopolysaccharidosis, type I
0.000 0.790 0.210
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.790 0.210
E77.8 Other disorders of glycoprotein metabolism
0.000 0.790 0.210
E77.1 Defects in glycoprotein degradation
0.000 0.790 0.210
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.790 0.210
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.792 0.208
E11.1 With ketoacidosis
0.000 0.798 0.202
E88.8 Other specified metabolic disorders
0.000 0.802 0.198
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.802 0.198
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.802 0.198
E72.5 Disorders of glycine metabolism
0.000 0.802 0.198
E72.4 Disorders of ornithine metabolism
0.000 0.802 0.198
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.802 0.198
E72.2 Disorders of urea cycle metabolism
0.000 0.802 0.198
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.802 0.198
R31 Unspecified haematuria
0.197 0.803 0.000
E89.4 Postprocedural ovarian failure
0.000 0.803 0.197
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.804 0.196

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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