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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs28383346
log Bayes Factor = 95.8386
Chromosome 6   position 32,605,326  (GRCh37) Explore rs28383346 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
1.000 0.000 0.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
M35.3 Polymyalgia rheumatica
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
J33 Nasal polyp
0.000 0.000 1.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
M35 Other systemic involvement of connective tissue
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
M05-M14 Inflammatory polyarthropathies
0.000 0.000 1.000
Chapter X Diseases of the respiratory system
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
# Top node
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
1.000 0.000 0.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
L40 Psoriasis
1.000 0.000 0.000
Chapter VII Diseases of the eye and adnexa
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.000 1.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.000 1.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.000 1.000
M05 Seropositive rheumatoid arthritis
0.000 0.000 1.000
J33.0 Polyp of nasal cavity
0.000 0.000 1.000
J30-J39 Other diseases of upper respiratory tract
0.000 0.000 1.000
H36.0 Diabetic retinopathy
0.000 0.000 1.000
M20-M25 Other joint disorders
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
M35.0 Sicca syndrome [Sjogren]
0.000 0.001 0.999
J33.9 Nasal polyp, unspecified
0.000 0.001 0.999
J47 Bronchiectasis
0.000 0.001 0.999
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.000 0.002 0.998
J40-J47 Chronic lower respiratory diseases
0.000 0.002 0.998
H36 Retinal disorders in diseases classified elsewhere
0.000 0.002 0.998
J80-J84 Other respiratory diseases principally affecting the interstitium
0.000 0.002 0.998
E10.1 With ketoacidosis
0.000 0.003 0.997
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.003 0.997
H30-H36 Disorders of choroid and retina
0.000 0.003 0.997
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.003 0.997
G35 Multiple sclerosis
0.000 0.008 0.992
J20-J22 Other acute lower respiratory infections
0.000 0.010 0.990
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.010 0.990
M34 Systemic sclerosis
0.000 0.014 0.986
L20-L30 Dermatitis and eczema
0.000 0.014 0.986
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.016 0.984
D50-D53 Nutritional anaemias
0.000 0.016 0.984
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.019 0.981
J22 Unspecified acute lower respiratory infection
0.000 0.020 0.980
E20-E35 Disorders of other endocrine glands
0.000 0.021 0.979
L80-L99 Other disorders of the skin and subcutaneous tissue
0.000 0.025 0.975
H55-H59 Other disorders of eye and adnexa
0.000 0.025 0.975
J32 Chronic sinusitis
0.000 0.029 0.971
J95-J99 Other diseases of the respiratory system
0.000 0.030 0.970
E10.4 With neurological complications
0.000 0.032 0.968
J80 Adult respiratory distress syndrome
0.000 0.036 0.964
D50 Iron deficiency anaemia
0.000 0.036 0.964
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.038 0.962
J84 Other interstitial pulmonary diseases
0.000 0.038 0.962
H04 Disorders of lachrymal system
0.000 0.041 0.959
H02 Other disorders of eyelid
0.000 0.043 0.957
E27 Other disorders of adrenal gland
0.000 0.045 0.955
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.046 0.954
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.048 0.952
L40.0 Psoriasis vulgaris
0.951 0.049 0.000
D50.8 Other iron deficiency anaemias
0.000 0.052 0.948
M34.9 Systemic sclerosis, unspecified
0.000 0.052 0.948
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.054 0.946
H57 Other disorders of eye and adnexa
0.000 0.054 0.946
D69 Purpura and other haemorrhagic conditions
0.000 0.058 0.942
L57 Skin changes due to chronic exposure to nonionising radiation
0.000 0.061 0.939
E27.1 Primary adrenocortical insufficiency
0.000 0.063 0.937
E10.5 With peripheral circulatory complications
0.000 0.066 0.934
L30 Other dermatitis
0.000 0.067 0.933
N48 Other disorders of penis
0.932 0.068 0.000
D68 Other coagulation defects
0.000 0.074 0.926
J95 Postprocedural respiratory disorders, not elsewhere classified
0.000 0.075 0.925
H02.1 Ectropion of eyelid
0.000 0.076 0.924
N48.6 Balanitis xerotica obliterans
0.922 0.078 0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.000 0.081 0.919
E10.2 With renal complications
0.000 0.081 0.919
H02.0 Entropion and trichiasis of eyelid
0.000 0.082 0.918
L29 Pruritus
0.000 0.083 0.917
J32.0 Chronic maxillary sinusitis
0.000 0.084 0.916
J31 Chronic rhinitis, nasopharyngitis and pharyngitis
0.000 0.084 0.916
L81 Other disorders of pigmentation
0.000 0.084 0.916
J33.8 Other polyp of sinus
0.000 0.086 0.914
Chapter VI Diseases of the nervous system
0.000 0.087 0.913
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.088 0.912
M06.0 Seronegative rheumatoid arthritis
0.000 0.091 0.909
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.092 0.908
J84.9 Interstitial pulmonary disease, unspecified
0.000 0.093 0.907
H04.5 Stenosis and insufficiency of lachrymal passages
0.000 0.095 0.905
J44 Other chronic obstructive pulmonary disease
0.000 0.096 0.904
E06 Thyroiditis
0.000 0.096 0.904
N48.8 Other specified disorders of penis
0.903 0.097 0.000
L57.8 Other skin changes due to chronic exposure to nonionising radiation
0.000 0.100 0.900
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.000 0.101 0.899
H57.0 Anomalies of pupillary function
0.000 0.102 0.898
E23 Hypofunction and other disorders of pituitary gland
0.000 0.105 0.895
M06.3 Rheumatoid nodule
0.000 0.107 0.893
L81.4 Other melanin hyperpigmentation
0.000 0.120 0.880
H05 Disorders of orbit
0.000 0.121 0.879
J95.8 Other postprocedural respiratory disorders
0.000 0.122 0.878
M35.1 Other overlap syndromes
0.000 0.124 0.876
L29.0 Pruritus ani
0.000 0.129 0.871
M34.1 CR(E)ST syndrome
0.000 0.131 0.869
L98 Other disorders of skin and subcutaneous tissue, not elsewhere classified
0.000 0.134 0.866
L85 Other epidermal thickening
0.000 0.137 0.863
M06.4 Inflammatory polyarthropathy
0.000 0.137 0.862
H06.2 Dysthyroid exophthalmos
0.000 0.138 0.862
N48.0 Leukoplakia of penis
0.861 0.139 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.140 0.860
L30.9 Dermatitis, unspecified
0.000 0.141 0.859
J81 Pulmonary oedema
0.000 0.141 0.859
E07 Other disorders of thyroid
0.000 0.145 0.855
J31.0 Chronic rhinitis
0.000 0.149 0.851
J44.8 Other specified chronic obstructive pulmonary disease
0.000 0.152 0.848
N48.9 Disorder of penis, unspecified
0.846 0.154 0.000
N48.4 Impotence of organic origin
0.845 0.155 0.000
J32.9 Chronic sinusitis, unspecified
0.000 0.156 0.844
H16 Keratitis
0.000 0.159 0.841
L30.8 Other specified dermatitis
0.000 0.167 0.833
H02.6 Xanthelasma of eyelid
0.000 0.167 0.833
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.000 0.168 0.832
E06.3 Autoimmune thyroiditis
0.000 0.169 0.831
D52 Folate deficiency anaemia
0.000 0.170 0.830
M06.34 Rheumatoid nodule (Hand)
0.000 0.173 0.827
M34.8 Other forms of systemic sclerosis
0.000 0.174 0.826
L97 Ulcer of lower limb, not elsewhere classified
0.000 0.175 0.825
D68.8 Other specified coagulation defects
0.000 0.177 0.823
D60-D64 Aplastic and other anaemias
0.000 0.181 0.819
J32.8 Other chronic sinusitis
0.000 0.181 0.819
L94 Other localised connective tissue disorders
0.000 0.185 0.815
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.186 0.814
N48.1 Balanoposthitis
0.814 0.186 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.188 0.812
L85.9 Epidermal thickening, unspecified
0.000 0.189 0.811
M32 Systemic lupus erythematosus
0.000 0.189 0.811
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.195 0.805
L95 Vasculitis limited to skin, not elsewhere classified
0.000 0.195 0.805
H20 Iridocyclitis
0.000 0.196 0.804
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.197 0.803
L21 Seborrhoeic dermatitis
0.000 0.197 0.803
J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection
0.000 0.197 0.803
E28 Ovarian dysfunction
0.000 0.197 0.803
D68.9 Coagulation defect, unspecified
0.000 0.198 0.802
D68.5 Primary Thrombophilia
0.000 0.198 0.802
H57.8 Other specified disorders of eye and adnexa
0.000 0.199 0.801
L93 Lupus erythematosus
0.000 0.202 0.798
L83 Acanthosis nigricans
0.000 0.203 0.797
H55 Nystagmus and other irregular eye movements
0.000 0.203 0.797
E20 Hypoparathyroidism
0.000 0.203 0.797
J82 Pulmonary eosinophilia, not elsewhere classified
0.000 0.204 0.795
L57.0 Actinic keratosis
0.000 0.206 0.794
H04.8 Other disorders of lachrymal system
0.000 0.208 0.792
H16.0 Corneal ulcer
0.000 0.210 0.790
J95.0 Tracheostomy malfunction
0.000 0.210 0.790
E10.8 With unspecified complications
0.000 0.213 0.787
J99 Respiratory disorders in diseases classified elsewhere
0.000 0.217 0.783
E29 Testicular dysfunction
0.000 0.217 0.783
J84.1 Other interstitial pulmonary diseases with fibrosis
0.000 0.217 0.783
H05.0 Acute inflammation of orbit
0.000 0.219 0.780
D69.0 Allergic purpura
0.000 0.220 0.780
E23.2 Diabetes insipidus
0.000 0.221 0.779
H04.4 Chronic inflammation of lachrymal passages
0.000 0.224 0.775
D69.5 Secondary thrombocytopenia
0.000 0.225 0.775
L98.4 Chronic ulcer of skin, not elsewhere classified
0.000 0.226 0.774
H04.3 Acute and unspecified inflammation of lachrymal passages
0.000 0.228 0.772
J98 Other respiratory disorders
0.000 0.229 0.771
J84.8 Other specified interstitial pulmonary diseases
0.000 0.231 0.769
D51 Vitamin B12 deficiency anaemia
0.000 0.233 0.767
E05.8 Other thyrotoxicosis
0.000 0.233 0.766
L40-L45 Papulosquamous disorders
0.381 0.236 0.383
J21 Acute bronchiolitis
0.000 0.238 0.762
D61 Other aplastic anaemias
0.000 0.239 0.761
N48.5 Ulcer of penis
0.761 0.239 0.000
E16 Other disorders of pancreatic internal secretion
0.000 0.240 0.760
M35.7 Hypermobility syndrome
0.000 0.241 0.759
E04 Other non-toxic goitre
0.000 0.242 0.758
G37 Other demyelinating diseases of central nervous system
0.000 0.244 0.756
L98.8 Other specified disorders of skin and subcutaneous tissue
0.000 0.245 0.755
H57.9 Disorder of eye and adnexa, unspecified
0.000 0.246 0.754
E27.8 Other specified disorders of adrenal gland
0.000 0.246 0.754
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.246 0.754
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.251 0.749
M22 Disorders of patella
0.000 0.252 0.748
E07.9 Disorder of thyroid, unspecified
0.000 0.252 0.748
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.253 0.747
L29.2 Pruritus vulvae
0.000 0.254 0.746
J20 Acute bronchitis
0.000 0.255 0.745
L20 Atopic dermatitis
0.000 0.257 0.743
G90-G99 Other disorders of the nervous system
0.000 0.258 0.742
L84 Corns and callosities
0.000 0.265 0.735
L25 Unspecified contact dermatitis
0.000 0.265 0.735
H58 Other disorders of eye and adnexa in diseases classified elsewhere
0.000 0.265 0.735
L57.4 Cutis laxa senilis
0.000 0.269 0.731
H05.2 Exophthalmic conditions
0.000 0.273 0.727
J32.1 Chronic frontal sinusitis
0.000 0.276 0.723
L80 Vitiligo
0.000 0.277 0.723
E10.6 With other specified complications
0.000 0.278 0.722
D61.9 Aplastic anaemia, unspecified
0.000 0.279 0.721
D52.9 Folate deficiency anaemia, unspecified
0.000 0.279 0.720
D68.0 Von Willebrand's disease
0.000 0.281 0.719
L28 Lichen simplex chronicus and prurigo
0.000 0.282 0.718
L56 Other acute skin changes due to ultraviolet radiation
0.000 0.282 0.718
E26 Hyperaldosteronism
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E10.0 With coma
0.000 0.283 0.717
J33.1 Polypoid sinus degeneration
0.000 0.283 0.717
M06.8 Other specified rheumatoid arthritis
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M06.1 Adult-onset Still's disease
0.000 0.283 0.717
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.283 0.717
M35.8 Other specified systemic involvement of connective tissue
0.000 0.283 0.717
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.283 0.717
M35.5 Multifocal fibrosclerosis
0.000 0.283 0.717
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.283 0.717
M35.2 Behcet's disease
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.283 0.717
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.283 0.717
M08 Juvenile arthritis
0.000 0.283 0.717
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.717 0.283 0.000
L40.3 Pustulosis palmaris et plantaris
0.717 0.283 0.000
L40.2 Acrodermatitis continua
0.717 0.283 0.000
L40.1 Generalised pustular psoriasis
0.717 0.283 0.000
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.1 Congenital hypothyroidism without goitre
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.283 0.717
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.283 0.717
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.283 0.717
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.283 0.717
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.283 0.717
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.283 0.717
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.283 0.717
M05.8 Other seropositive rheumatoid arthritis
0.000 0.283 0.717
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.283 0.717
M05.2 Rheumatoid vasculitis
0.000 0.283 0.717
M05.1 Rheumatoid lung disease
0.000 0.283 0.717
M05.0 Felty's syndrome
0.000 0.283 0.717
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
J41 Simple and mucopurulent chronic bronchitis
0.000 0.284 0.716
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.284 0.716
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.285 0.715
H03 Disorders of eyelid in diseases classified elsewhere
0.000 0.286 0.714
L98.9 Disorder of skin and subcutaneous tissue, unspecified
0.000 0.286 0.714
E16.2 Hypoglycaemia, unspecified
0.000 0.287 0.713
E23.0 Hypopituitarism
0.000 0.287 0.713
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.289 0.711
H01 Other inflammation of eyelid
0.000 0.291 0.708
M30 Polyarteritis nodosa and related conditions
0.000 0.293 0.707
M34.2 Systemic sclerosis induced by drugs and chemicals
0.000 0.293 0.707
M34.0 Progressive systemic sclerosis
0.000 0.293 0.707
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.293 0.707
L24 Irritant contact dermatitis
0.000 0.293 0.707
L26 Exfoliative dermatitis
0.000 0.293 0.707
L22 Diaper [napkin] dermatitis
0.000 0.293 0.707
L27 Dermatitis due to substances taken internally
0.000 0.296 0.704
D67 Hereditary factor IX deficiency
0.000 0.296 0.703
E23.6 Other disorders of pituitary gland
0.000 0.297 0.703
H04.9 Disorder of lachrymal system, unspecified
0.000 0.297 0.703
E04.2 Non-toxic multinodular goitre
0.000 0.298 0.702
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.298 0.702
E32 Diseases of thymus
0.000 0.298 0.702
E31 Polyglandular dysfunction
0.000 0.298 0.702
E30 Disorders of puberty, not elsewhere classified
0.000 0.298 0.702
M60-M63 Disorders of muscles
0.000 0.300 0.700
J60-J70 Lung diseases due to external agents
0.000 0.300 0.700
L99 Other disorders of skin and subcutaneous tissue in diseases classified elsewhere
0.000 0.301 0.699
L87 Transepidermal elimination disorders
0.000 0.301 0.699
L88 Pyoderma gangrenosum
0.000 0.301 0.699
L86 Keratoderma in diseases classified elsewhere
0.000 0.301 0.699
J32.3 Chronic sphenoidal sinusitis
0.000 0.304 0.696
J99.1 Respiratory disorders in other diffuse connective tissue disorders
0.000 0.304 0.696
J96 Respiratory failure, not elsewhere classified
0.000 0.305 0.695
D69.6 Thrombocytopenia, unspecified
0.000 0.309 0.691
D50.1 Sideropenic dysphagia
0.000 0.309 0.691
H02.5 Other disorders affecting eyelid function
0.000 0.309 0.691
J98.1 Pulmonary collapse
0.000 0.309 0.691
L58 Radiodermatitis
0.000 0.310 0.690
L55 Sunburn
0.000 0.310 0.690
J84.0 Alveolar and parietoalveolar conditions
0.000 0.310 0.690
H04.6 Other changes in lachrymal passages
0.000 0.312 0.688
H04.0 Dacryoadenitis
0.000 0.312 0.688
M00-M03 Infectious arthropathies
0.000 0.313 0.687
H30 Chorioretinal inflammation
0.000 0.313 0.687
E14 Unspecified diabetes mellitus
0.000 0.313 0.687
M12 Other specific arthropathies
0.000 0.313 0.687
H02.7 Other degenerative disorders of eyelid and periocular area
0.000 0.314 0.686
M86-M90 Other osteopathies
0.000 0.314 0.685
E27.5 Adrenomedullary hyperfunction
0.000 0.315 0.684
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.315 0.684
E27.0 Other adrenocortical overactivity
0.000 0.315 0.684
E27.9 Disorder of adrenal gland, unspecified
0.000 0.317 0.683
G36 Other acute disseminated demyelination
0.000 0.317 0.683
D68.6 Other Thrombophilia
0.000 0.317 0.683
E03.8 Other specified hypothyroidism
0.000 0.318 0.682
H19 Disorders of sclera and cornea in diseases classified elsewhere
0.000 0.319 0.681
J98.0 Diseases of bronchus, not elsewhere classified
0.000 0.319 0.681
G91 Hydrocephalus
0.000 0.321 0.679
H20.8 Other iridocyclitis
0.000 0.321 0.679
L40.8 Other psoriasis
0.677 0.323 0.000
J31.2 Chronic pharyngitis
0.000 0.323 0.677
J00-J06 Acute upper respiratory infections
0.000 0.324 0.676
D69.8 Other specified haemorrhagic conditions
0.000 0.324 0.676
D69.4 Other primary thrombocytopenia
0.000 0.324 0.676
D69.1 Qualitative platelet defects
0.000 0.324 0.676
L94.0 Localised scleroderma [morphea]
0.000 0.324 0.676
M32.1 Systemic lupus erythematosus with organ or system involvement
0.000 0.325 0.675
N40-N51 Diseases of male genital organs
0.675 0.325 0.000
L57.9 Skin changes due to chronic exposure to nonionising radiation, unspecified
0.000 0.327 0.673
L57.5 Actinic granuloma
0.000 0.327 0.673
L57.3 Poikiloderma of Civatte
0.000 0.327 0.673
L57.2 Cutis rhomboidalis nuchae
0.000 0.327 0.673
L57.1 Actinic reticuloid
0.000 0.327 0.673
N48.2 Other inflammatory disorders of penis
0.673 0.327 0.000
L82 Seborrhoeic keratosis
0.000 0.327 0.673
L21.9 Seborrhoeic dermatitis, unspecified
0.000 0.328 0.672
D53 Other nutritional anaemias
0.000 0.328 0.672
L93.0 Discoid lupus erythematosus
0.000 0.329 0.671
J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified
0.000 0.330 0.670
L30.5 Pityriasis alba
0.000 0.331 0.669
L30.4 Erythema intertrigo
0.000 0.331 0.669
L30.2 Cutaneous autosensitisation
0.000 0.331 0.669
L30.1 Dyshidrosis [pompholyx]
0.000 0.331 0.669
L30.0 Nummular dermatitis
0.000 0.331 0.669
N48.3 Priapism
0.668 0.332 0.000
H59 Postprocedural disorders of eye and adnexa, not elsewhere classified
0.000 0.332 0.668
E20.9 Hypoparathyroidism, unspecified
0.000 0.334 0.666
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.334 0.666
N47 Redundant prepuce, phimosis and paraphimosis
0.665 0.335 0.000
H20.9 Iridocyclitis, unspecified
0.000 0.336 0.664
D68.4 Acquired coagulation factor deficiency
0.000 0.336 0.664
D68.1 Hereditary factor XI deficiency
0.000 0.336 0.664
J95.5 Postprocedural subglottic stenosis
0.000 0.336 0.663
J95.4 Mendelson's syndrome
0.000 0.336 0.663
J95.3 Chronic pulmonary insufficiency following surgery
0.000 0.336 0.663
J95.2 Acute pulmonary insufficiency following nonthoracic surgery
0.000 0.336 0.663
J95.1 Acute pulmonary insufficiency following thoracic surgery
0.000 0.336 0.663
J37 Chronic laryngitis and laryngotracheitis
0.000 0.337 0.663
J32.4 Chronic pansinusitis
0.000 0.337 0.663
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.338 0.662
E06.9 Thyroiditis, unspecified
0.000 0.338 0.661
H16.9 Keratitis, unspecified
0.000 0.339 0.661
L10-L14 Bullous disorders
0.000 0.340 0.659
H06.3 Other disorders of orbit in diseases classified elsewhere
0.000 0.341 0.659
H06.1 Parasitic infestation of orbit in diseases classified elsewhere
0.000 0.341 0.659
H06.0 Disorders of lachrymal system in diseases classified elsewhere
0.000 0.341 0.659
M22.2 Patellofemoral disorders
0.000 0.342 0.658
L29.1 Pruritus scroti
0.000 0.342 0.658
G80-G83 Cerebral palsy and other paralytic syndromes
0.000 0.343 0.657
J31.1 Chronic nasopharyngitis
0.000 0.343 0.657
L81.7 Pigmented purpuric dermatosis
0.000 0.343 0.656
L81.6 Other disorders of diminished melanin formation
0.000 0.343 0.656
L81.5 Leukoderma, not elsewhere classified
0.000 0.343 0.656
L81.3 Cafe au lait spots
0.000 0.343 0.656
L81.2 Freckles
0.000 0.343 0.656
L81.1 Chloasma
0.000 0.343 0.656
L81.0 Postinflammatory hyperpigmentation
0.000 0.343 0.656
E23.7 Disorder of pituitary gland, unspecified
0.000 0.344 0.656
E27.2 Addisonian crisis
0.000 0.344 0.655
H02.2 Lagophthalmos
0.000 0.346 0.654
L29.9 Pruritus, unspecified
0.000 0.346 0.654
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.346 0.654
E22 Hyperfunction of pituitary gland
0.000 0.347 0.653
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.348 0.651
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.348 0.651
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.348 0.651
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.348 0.651
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.348 0.651
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.348 0.651
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.348 0.651
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.348 0.651
E06.5 Other chronic thyroiditis
0.000 0.352 0.648
E06.4 Drug-induced thyroiditis
0.000 0.352 0.648
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.352 0.648
E06.1 Subacute thyroiditis
0.000 0.352 0.648
E06.0 Acute thyroiditis
0.000 0.352 0.648
D62 Acute posthaemorrhagic anaemia
0.000 0.353 0.647
H57.1 Ocular pain
0.000 0.355 0.645
E28.3 Primary ovarian failure
0.000 0.356 0.644
L95.8 Other vasculitis limited to skin
0.000 0.356 0.644
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.356 0.644
E29.1 Testicular hypofunction
0.000 0.358 0.642
L94.2 Calcinosis cutis
0.000 0.358 0.642
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.358 0.642
E23.1 Drug-induced hypopituitarism
0.000 0.358 0.642
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.359 0.641
M06.38 Rheumatoid nodule (Other)
0.000 0.359 0.641
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.359 0.641
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.359 0.641
M06.33 Rheumatoid nodule (Forearm)
0.000 0.359 0.641
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.359 0.641
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.359 0.641
L81.9 Disorder of pigmentation, unspecified
0.000 0.365 0.635
M33 Dermatopolymyositis
0.000 0.365 0.635
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.366 0.634
L29.8 Other pruritus
0.000 0.366 0.634
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.366 0.633
L59 Other disorders of skin and subcutaneous tissue related to radiation
0.000 0.367 0.633
L95.9 Vasculitis limited to skin, unspecified
0.000 0.367 0.633
H05.5 Retained (old) foreign body following penetrating wound of orbit
0.000 0.370 0.630
H05.3 Deformity of orbit
0.000 0.370 0.630
H05.1 Chronic inflammatory disorders of orbit
0.000 0.370 0.630
L81.8 Other specified disorders of pigmentation
0.000 0.370 0.630
L23 Allergic contact dermatitis
0.000 0.372 0.628
H05.8 Other disorders of orbit
0.000 0.372 0.627
E34 Other endocrine disorders
0.000 0.372 0.627
G80 Infantile cerebral palsy
0.000 0.376 0.624
E65-E68 Obesity and other hyperalimentation
0.000 0.376 0.624
H04.1 Other disorders of lachrymal gland
0.000 0.376 0.624
E28.2 Polycystic ovarian syndrome
0.000 0.378 0.622
M31 Other necrotising vasculopathies
0.000 0.378 0.622
L98.7 Excessive and redundant skin and subcutaneous tissue
0.000 0.379 0.621
L98.6 Other infiltrative disorders of skin and subcutaneous tissue
0.000 0.379 0.621
L98.3 Eosinophilic cellulitis [Wells]
0.000 0.379 0.621
L98.1 Factitial dermatitis
0.000 0.379 0.621
E07.8 Other specified disorders of thyroid
0.000 0.379 0.621
M11 Other crystal arthropathies
0.000 0.380 0.620
L85.3 Xerosis cutis
0.000 0.381 0.618
L85.2 Keratosis punctata (palmaris et plantaris)
0.000 0.381 0.618
L85.1 Acquired keratosis [keratoderma] palmaris et plantaris
0.000 0.381 0.618
L85.0 Acquired ichthyosis
0.000 0.381 0.618
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.381 0.618
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.381 0.618
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.381 0.618
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.381 0.618
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.381 0.618
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.381 0.618
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.381 0.618
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.381 0.618
E15 Nondiabetic hypoglycaemic coma
0.000 0.383 0.617
E25 Adrenogenital disorders
0.000 0.383 0.616
J98.9 Respiratory disorder, unspecified
0.000 0.384 0.616
H31 Other disorders of choroid
0.000 0.385 0.615
H15 Disorders of sclera
0.000 0.385 0.614
G91.9 Hydrocephalus, unspecified
0.000 0.386 0.614
E40-E46 Malnutrition
0.000 0.386 0.613
E07.1 Dyshormogenetic goitre
0.000 0.387 0.613
E07.0 Hypersecretion of calcitonin
0.000 0.387 0.613
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.387 0.613
H17 Corneal scars and opacities
0.000 0.394 0.606
D55-D59 Haemolytic anaemias
0.000 0.395 0.605
H20.0 Acute and subacute iridocyclitis
0.000 0.396 0.604
H16.8 Other keratitis
0.000 0.397 0.603
H16.4 Corneal neovascularisation
0.000 0.397 0.603
H16.3 Interstitial and deep keratitis
0.000 0.397 0.603
H16.1 Other superficial keratitis without conjunctivitis
0.000 0.397 0.603
M14 Arthropathies in other diseases classified elsewhere
0.000 0.397 0.603
J42 Unspecified chronic bronchitis
0.000 0.397 0.603
G90 Disorders of autonomic nervous system
0.000 0.398 0.602
G80.9 Infantile cerebral palsy, unspecified
0.000 0.399 0.601
E04.0 Non-toxic diffuse goitre
0.000 0.400 0.600
J21.9 Acute bronchiolitis, unspecified
0.000 0.402 0.598
H01.8 Other specified inflammation of eyelid
0.000 0.404 0.596
D52.8 Other folate deficiency anaemias
0.000 0.405 0.595
D52.1 Drug-induced folate deficiency anaemia
0.000 0.405 0.595
D52.0 Dietary folate deficiency anaemia
0.000 0.405 0.595
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.406 0.594
J00 Acute nasopharyngitis [common cold]
0.000 0.407 0.593
D80-D89 Certain disorders involving the immune mechanism
0.000 0.407 0.593
J95.9 Postprocedural respiratory disorder, unspecified
0.000 0.410 0.590
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.000 0.411 0.588
J20.9 Acute bronchitis, unspecified
0.000 0.412 0.588
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.000 0.412 0.587
L98.5 Mucinosis of skin
0.000 0.414 0.586
H05.4 Enophthalmos
0.000 0.414 0.586
H16.2 Keratoconjunctivitis
0.000 0.415 0.585
L94.8 Other specified localised connective tissue disorders
0.000 0.415 0.585
L94.6 Ainhum
0.000 0.415 0.585
L94.5 Poikiloderma vasculare atrophicans
0.000 0.415 0.585
L94.4 Gottron's papules
0.000 0.415 0.585
L94.3 Sclerodactyly
0.000 0.415 0.585
L94.1 Linear scleroderma
0.000 0.415 0.585
J67 Hypersensitivity pneumonitis due to organic dust
0.000 0.417 0.583
J32.2 Chronic ethmoidal sinusitis
0.000 0.417 0.583
M32.9 Systemic lupus erythematosus, unspecified
0.000 0.419 0.581
M32.8 Other forms of systemic lupus erythematosus
0.000 0.419 0.581
M32.0 Drug-induced systemic lupus erythematosus
0.000 0.419 0.581
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.000 0.419 0.581
H00 Hordeolum and chalazion
0.000 0.419 0.581
H05.9 Disorder of orbit, unspecified
0.000 0.420 0.579
M22.3 Other derangements of patella
0.000 0.421 0.579
M89 Other disorders of bone
0.000 0.421 0.579
L95.1 Erythema elevatum diutinum
0.000 0.423 0.577

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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