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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs28408478
log Bayes Factor = 12.072
Chromosome 1   position 19,287,138  (GRCh37) Explore rs28408478 on Ensembl!
Variant rs28408478 is part of Cluster X0020

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter I Certain infectious and parasitic diseases
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.999 0.001 0.000
Chapter X Diseases of the respiratory system
0.998 0.002 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.997 0.003 0.000
B95-B98 Bacterial, viral and other infectious agents
0.996 0.004 0.000
Chapter VI Diseases of the nervous system
0.992 0.008 0.000
Chapter XX External causes of morbidity and mortality
0.991 0.009 0.000
B96 Other bacterial agents as the cause of diseases classified to other chapters
0.991 0.009 0.000
O60-O75 Complications of labour and delivery
0.988 0.012 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.978 0.022 0.000
J95-J99 Other diseases of the respiratory system
0.977 0.023 0.000
E70-E90 Metabolic disorders
0.970 0.030 0.000
E00-E07 Disorders of thyroid gland
0.964 0.036 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.962 0.038 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.959 0.041 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.959 0.041 0.000
J98 Other respiratory disorders
0.954 0.046 0.000
Y43 Primarily systemic agents
0.954 0.046 0.000
O70 Perineal laceration during delivery
0.954 0.046 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.953 0.047 0.000
O80-O84 Delivery
0.953 0.047 0.000
A00-A09 Intestinal infectious diseases
0.948 0.052 0.000
B96.5 Pseudomonas (aeruginosa)(mallei)(pseudomallei) as the cause of diseases classified to other chapters
0.947 0.053 0.000
G90-G99 Other disorders of the nervous system
0.945 0.055 0.000
O70.0 First degree perineal laceration during delivery
0.940 0.060 0.000
S40-S49 Injuries to the shoulder and upper arm
0.939 0.061 0.000
Y43.3 Other antineoplastic drugs
0.933 0.067 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.932 0.068 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.928 0.072 0.000
A09 Diarrhoea and gastro-enteritis of presumed infectious origin
0.922 0.078 0.000
S60-S69 Injuries to the wrist and hand
0.918 0.082 0.000
E87.1 Hypo-osmolality and hyponatraemia
0.916 0.084 0.000
O82 Single delivery by Caesarean section
0.915 0.085 0.000
G81 Hemiplegia
0.912 0.088 0.000
J98.1 Pulmonary collapse
0.911 0.089 0.000
E87.5 Hyperkalaemia
0.908 0.092 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.907 0.093 0.000
A09.9 Gastroenteritis and colitis of unspecified origin
0.906 0.094 0.000
G62 Other polyneuropathies
0.904 0.096 0.000
S70-S79 Injuries to the hip and thigh
0.904 0.096 0.000
S90-S99 Injuries to the ankle and foot
0.903 0.097 0.000
O69 Labour and delivery complicated by umbilical cord complications
0.903 0.097 0.000
B96.8 Other specified bacterial agents as the cause of diseases classified to other chapters
0.902 0.098 0.000
J00-J06 Acute upper respiratory infections
0.900 0.100 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.899 0.101 0.000
E10-E14 Diabetes mellitus
0.897 0.103 0.000
E04 Other non-toxic goitre
0.887 0.113 0.000
Chapter IX Diseases of the circulatory system
0.886 0.114 0.000
G81.9 Hemiplegia, unspecified
0.882 0.118 0.000
J86 Pyothorax
0.878 0.122 0.000
O75 Other complications of labour and delivery, not elsewhere classified
0.878 0.122 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.877 0.123 0.000
B96.1 Klebsiella pneumoniae [K. pneumoniae] as the cause of diseases classified to other chapters
0.876 0.124 0.000
G95 Other diseases of spinal cord
0.875 0.125 0.000
J98.4 Other disorders of lung
0.873 0.127 0.000
G93 Other disorders of brain
0.870 0.130 0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters
0.870 0.130 0.000
J60-J70 Lung diseases due to external agents
0.869 0.131 0.000
Chapter XIV Diseases of the genitourinary system
0.867 0.133 0.000
J09-J18 Influenza and pneumonia
0.866 0.134 0.000
O82.1 Delivery by emergency Caesarean section
0.857 0.143 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.853 0.147 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.852 0.148 0.000
N17-N19 Renal failure
0.851 0.149 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.848 0.152 0.000
B96.4 Proteus (mirabilis)(morganii) as the cause of diseases classified to other chapters
0.847 0.153 0.000
E86 Volume depletion
0.847 0.153 0.000
E87.0 Hyperosmolality and hypernatraemia
0.846 0.154 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.846 0.154 0.000
E11 Non-insulin-dependent diabetes mellitus
0.844 0.156 0.000
J86.9 Pyothorax without fistula
0.842 0.158 0.000
N17 Acute renal failure
0.842 0.158 0.000
I20-I25 Ischaemic heart diseases
0.838 0.162 0.000
J02 Acute pharyngitis
0.837 0.163 0.000
Chapter XXII Codes for special purposes
0.836 0.164 0.000
N17.9 Acute renal failure, unspecified
0.836 0.164 0.000
G62.9 Polyneuropathy, unspecified
0.834 0.166 0.000
J40-J47 Chronic lower respiratory diseases
0.829 0.171 0.000
E03 Other hypothyroidism
0.828 0.172 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.828 0.172 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.827 0.173 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.825 0.175 0.000
T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
0.825 0.175 0.000
S72 Fracture of femur
0.825 0.175 0.000
O85-O92 Complications predominantly related to the puerperium
0.822 0.178 0.000
E11.3 With ophthalmic complications
0.821 0.179 0.000
I21 Acute myocardial infarction
0.820 0.180 0.000
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle
0.813 0.187 0.000
S61 Open wound of wrist and hand
0.813 0.187 0.000
Y48 Anaesthetics and therapeutic gases
0.806 0.194 0.000
G82 Paraplegia and tetraplegia
0.806 0.194 0.000
G95.2 Cord compression, unspecified
0.803 0.197 0.000
I30-I52 Other forms of heart disease
0.803 0.197 0.000
I21.1 Acute transmural myocardial infarction of inferior wall
0.803 0.197 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.802 0.198 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.802 0.198 0.000
B15-B19 Viral hepatitis
0.800 0.200 0.000
B99-B99 Other infectious diseases
0.800 0.200 0.000
E07 Other disorders of thyroid
0.798 0.202 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.795 0.205 0.000
Y95 Nosocomial condition
0.795 0.205 0.000
O32 Maternal care for known or suspected malpresentation of foetus
0.794 0.206 0.000
O82.0 Delivery by elective Caesarean section
0.794 0.206 0.000
N25-N29 Other disorders of kidney and ureter
0.793 0.207 0.000
J02.9 Acute pharyngitis, unspecified
0.792 0.208 0.000
E74 Other disorders of carbohydrate metabolism
0.792 0.208 0.000
S50-S59 Injuries to the elbow and forearm
0.789 0.211 0.000
S61.0 Open wound of finger(s) without damage to nail
0.788 0.212 0.000
S60 Superficial injury of wrist and hand
0.787 0.213 0.000
V10-V19 Pedal cyclist injured in transport accident
0.784 0.216 0.000
S46 Injury of muscle and tendon at shoulder and upper arm level
0.783 0.217 0.000
K80-K87 Disorders of gallbladder, biliary tract and pancreas
0.783 0.217 0.000
E04.2 Non-toxic multinodular goitre
0.783 0.217 0.000
K80 Cholelithiasis
0.782 0.218 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.780 0.220 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.778 0.222 0.000
T85.9 Unspecified complication of internal prosthetic device, implant and graft
0.773 0.227 0.000
J18 Pneumonia, organism unspecified
0.773 0.227 0.000
K80.5 Calculus of bile duct without cholangitis or cholecystitis
0.772 0.228 0.000
B25-B34 Other viral diseases
0.771 0.228 0.000
J95 Postprocedural respiratory disorders, not elsewhere classified
0.771 0.229 0.000
T66-T78 Other and unspecified effects of external causes
0.770 0.230 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.770 0.230 0.000
N99-N99 Other disorders of the genitourinary system
0.768 0.232 0.000
O69.2 Labour and delivery complicated by other cord entanglement
0.768 0.232 0.000
Q80-Q89 Other congenital malformations
0.768 0.232 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.768 0.232 0.000
B35-B49 Mycoses
0.764 0.236 0.000
O69.1 Labour and delivery complicated by cord around neck, with compression
0.764 0.236 0.000
E04.9 Non-toxic goitre, unspecified
0.763 0.237 0.000
O48 Prolonged pregnancy
0.761 0.239 0.000
B96.2 Escherichia coli [E. coli] as the cause of diseases classified to other chapters
0.760 0.240 0.000
K83 Other diseases of biliary tract
0.760 0.240 0.000
J40 Bronchitis, not specified as acute or chronic
0.759 0.241 0.000
I42 Cardiomyopathy
0.759 0.241 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.757 0.243 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.757 0.243 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.757 0.243 0.000
E40-E46 Malnutrition
0.754 0.246 0.000
T85.6 Mechanical complication of other specified internal prosthetic devices, implants and grafts
0.753 0.247 0.000
J18.1 Lobar pneumonia, unspecified
0.752 0.248 0.000
S90 Superficial injury of ankle and foot
0.752 0.248 0.000
B98 Other specified infectious agents as the cause of diseases classified to other chapters
0.750 0.250 0.000
S42 Fracture of shoulder and upper arm
0.750 0.250 0.000
G93.1 Anoxic brain damage, not elsewhere classified
0.750 0.250 0.000
O70.2 Third degree perineal laceration during delivery
0.749 0.251 0.000
T79-T79 Certain early complications of trauma
0.748 0.252 0.000
B95.7 Other staphylococcus as the cause of diseases classified to other chapters
0.748 0.252 0.000
O68 Labour and delivery complicated by foetal stress [distress]
0.747 0.253 0.000
G61 Inflammatory polyneuropathy
0.747 0.253 0.000
O73 Retained placenta and membranes, without haemorrhage
0.747 0.253 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.746 0.254 0.000
G70-G73 Diseases of myoneural junction and muscle
0.745 0.255 0.000
I21.9 Acute myocardial infarction, unspecified
0.745 0.255 0.000
O44 Placenta praevia
0.744 0.256 0.000
O41 Other disorders of amniotic fluid and membranes
0.743 0.257 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.742 0.258 0.000
O70.9 Perineal laceration during delivery, unspecified
0.741 0.259 0.000
W20-W49 Exposure to inanimate mechanical forces
0.739 0.261 0.000
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts
0.738 0.262 0.000
J69 Pneumonitis due to solids and liquids
0.738 0.262 0.000
I22 Subsequent myocardial infarction
0.737 0.263 0.000
E04.0 Non-toxic diffuse goitre
0.737 0.263 0.000
S91 Open wound of ankle and foot
0.737 0.263 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.737 0.263 0.000
Y43.4 Immunosuppressive agents
0.736 0.264 0.000
B65-B83 Helminthiases
0.736 0.264 0.000
Q28 Other congenital malformations of circulatory system
0.736 0.264 0.000
G60 Hereditary and idiopathic neuropathy
0.735 0.264 0.000
Chapter II Neoplasms
0.735 0.265 0.000
A30-A49 Other bacterial diseases
0.734 0.266 0.000
A80-A89 Viral infections of the central nervous system
0.732 0.267 0.000
O62 Abnormalities of forces of labour
0.732 0.268 0.000
T85.4 Mechanical complication of breast prosthesis and implant
0.731 0.269 0.000
Y52 Agents primarily affecting the cardiovascular system
0.730 0.270 0.000
O47 False labour
0.729 0.271 0.000
O75.7 Vaginal delivery following previous Caesarean section
0.729 0.271 0.000
L02 Cutaneous abscess, furuncle and carbuncle
0.729 0.271 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.728 0.272 0.000
J44 Other chronic obstructive pulmonary disease
0.727 0.273 0.000
J99 Respiratory disorders in diseases classified elsewhere
0.727 0.273 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.726 0.274 0.000
J98.8 Other specified respiratory disorders
0.725 0.275 0.000
S92 Fracture of foot, except ankle
0.725 0.275 0.000
K82 Other diseases of gallbladder
0.724 0.276 0.000
G62.8 Other specified polyneuropathies
0.724 0.276 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.723 0.277 0.000
S43.0 Dislocation of shoulder joint
0.723 0.277 0.000
S72.0 Fracture of neck of femur
0.722 0.278 0.000
S62 Fracture at wrist and hand level
0.722 0.278 0.000
K83.1 Obstruction of bile duct
0.721 0.279 0.000
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.720 0.280 0.000
N28 Other disorders of kidney and ureter, not elsewhere classified
0.719 0.281 0.000
G96 Other disorders of central nervous system
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.717 0.283 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.717 0.283 0.000
B50-B64 Protozoal diseases
0.717 0.283 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.717 0.283 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.717 0.283 0.000
A75-A79 Rickettsioses
0.717 0.283 0.000
A70-A74 Other diseases caused by chlamydiae
0.717 0.283 0.000
A65-A69 Other spirochaetal diseases
0.717 0.283 0.000
A20-A28 Certain zoonotic bacterial diseases
0.717 0.283 0.000
A15-A19 Tuberculosis
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
S10-S19 Injuries to the neck
0.717 0.283 0.000
E87.2 Acidosis
0.716 0.284 0.000
Y44 Agents primarily affecting blood constituents
0.716 0.284 0.000
J03 Acute tonsillitis
0.715 0.285 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.714 0.285 0.000
O80 Single spontaneous delivery
0.714 0.286 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.713 0.287 0.000
O35 Maternal care for known or suspected foetal abnormality and damage
0.712 0.288 0.000
O32.1 Maternal care for breech presentation
0.711 0.289 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.711 0.289 0.000
Y35-Y36 Legal intervention and operations of war
0.711 0.289 0.000
Y10-Y34 Event of undetermined intent
0.711 0.289 0.000
Y00-Y09 Assault
0.711 0.289 0.000
X85-X99 Assault
0.711 0.289 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.711 0.289 0.000
X50-X57 Overexertion, travel and privation
0.711 0.289 0.000
X30-X39 Exposure to forces of nature
0.711 0.289 0.000
X20-X29 Contact with venomous animals and plants
0.711 0.289 0.000
X10-X19 Contact with heat and hot substances
0.711 0.289 0.000
X00-X09 Exposure to smoke, fire and flames
0.711 0.289 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.711 0.289 0.000
W75-W84 Other accidental threats to breathing
0.711 0.289 0.000
W65-W74 Accidental drowning and submersion
0.711 0.289 0.000
W50-W64 Exposure to animate mechanical forces
0.711 0.289 0.000
V98-V99 Other and unspecified transport accidents
0.711 0.289 0.000
V95-V97 Air and space transport accidents
0.711 0.289 0.000
V90-V94 Water transport accidents
0.711 0.289 0.000
V70-V79 Bus occupant injured in transport accident
0.711 0.289 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.711 0.289 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.711 0.289 0.000
V40-V49 Car occupant injured in transport accident
0.711 0.289 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.711 0.289 0.000
V20-V29 Motorcycle rider injured in transport accident
0.711 0.289 0.000
V01-V09 Pedestrian injured in transport accident
0.711 0.289 0.000
B96.7 Clostridium perfringens [C. perfringens] as the cause of diseases classified to other chapters
0.711 0.289 0.000
B96.6 Bacillus fragilis [B. fragilis] as the cause of diseases classified to other chapters
0.711 0.289 0.000
B96.0 Mycoplasma pneumoniae [M. pneumoniae] as the cause of diseases classified to other chapters
0.711 0.289 0.000
G20-G26 Extrapyramidal and movement disorders
0.710 0.290 0.000
N19 Unspecified renal failure
0.710 0.290 0.000
X60-X84 Intentional self-harm
0.708 0.292 0.000
O74 Complications of anaesthesia during labour and delivery
0.708 0.292 0.000
O71 Other obstetric trauma
0.708 0.292 0.000
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified
0.708 0.292 0.000
O65 Obstructed labour due to maternal pelvic abnormality
0.708 0.292 0.000
O61 Failed induction of labour
0.708 0.292 0.000
O60 Preterm delivery
0.708 0.292 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.707 0.293 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.707 0.293 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.706 0.294 0.000
S41 Open wound of shoulder and upper arm
0.706 0.294 0.000
G62.0 Drug-induced polyneuropathy
0.705 0.295 0.000
T86 Failure and rejection of transplanted organs and tissues
0.703 0.297 0.000
G93.3 Postviral fatigue syndrome
0.703 0.297 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.702 0.298 0.000
E03.9 Hypothyroidism, unspecified
0.701 0.299 0.000
Y59 Other and unspecified vaccines and biological substances
0.701 0.299 0.000
Y58 Bacterial vaccines
0.701 0.299 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.701 0.299 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.701 0.299 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.701 0.299 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.701 0.299 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.701 0.299 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.701 0.299 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.701 0.299 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.701 0.299 0.000
S60.9 Superficial injury of wrist and hand, unspecified
0.701 0.299 0.000
J96 Respiratory failure, not elsewhere classified
0.700 0.299 0.000
J84 Other interstitial pulmonary diseases
0.699 0.301 0.000
N99 Postprocedural disorders of genito-urinary system, not elsewhere classified
0.698 0.302 0.000
N00-N08 Glomerular diseases
0.697 0.302 0.000
J15 Bacterial pneumonia, not elsewhere classified
0.697 0.303 0.000
J61 Pneumoconiosis due to asbestos and other mineral fibres
0.696 0.303 0.000
T82.3 Mechanical complication of other vascular grafts
0.697 0.303 0.000
T83.4 Mechanical complication of other prosthetic devices, implants and grafts in genital tract
0.696 0.303 0.000
O75.0 Maternal distress during labour and delivery
0.696 0.304 0.000
E11.4 With neurological complications
0.696 0.304 0.000
I21.0 Acute transmural myocardial infarction of anterior wall
0.696 0.304 0.000
S70 Superficial injury of hip and thigh
0.695 0.305 0.000
E85 Amyloidosis
0.695 0.305 0.000
E84 Cystic fibrosis
0.695 0.305 0.000
E79 Disorders of purine and pyrimidine metabolism
0.695 0.305 0.000
E77 Disorders of glycoprotein metabolism
0.695 0.305 0.000
E76 Disorders of glycosaminoglycan metabolism
0.695 0.305 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.695 0.305 0.000
E73 Lactose intolerance
0.695 0.305 0.000
E72 Other disorders of amino-acid metabolism
0.695 0.305 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.695 0.305 0.000
E70 Disorders of aromatic amino-acid metabolism
0.695 0.305 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.695 0.305 0.000
I42.0 Dilated cardiomyopathy
0.695 0.305 0.000
O90 Complications of the puerperium, not elsewhere classified
0.695 0.305 0.000
Q27 Other congenital malformations of peripheral vascular system
0.693 0.307 0.000
Q50-Q56 Congenital malformations of genital organs
0.693 0.307 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.693 0.307 0.000
O69.8 Labour and delivery complicated by other cord complications
0.693 0.307 0.000
I31 Other diseases of pericardium
0.692 0.308 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.692 0.308 0.000
E20-E35 Disorders of other endocrine glands
0.692 0.308 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.691 0.309 0.000
E00 Congenital iodine-deficiency syndrome
0.691 0.309 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.691 0.309 0.000
S40 Superficial injury of shoulder and upper arm
0.691 0.309 0.000
I71 Aortic aneurysm and dissection
0.690 0.310 0.000
L60-L75 Disorders of skin appendages
0.690 0.310 0.000
T87 Complications peculiar to reattachment and amputation
0.690 0.310 0.000
E87.4 Mixed disorder of acid-base balance
0.687 0.313 0.000
E87.3 Alkalosis
0.687 0.313 0.000
G64 Other disorders of peripheral nervous system
0.687 0.313 0.000
E88 Other metabolic disorders
0.686 0.313 0.000
V80-V89 Other land transport accidents
0.686 0.314 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.686 0.314 0.000
Q60-Q64 Congenital malformations of the urinary system
0.685 0.315 0.000
J98.9 Respiratory disorder, unspecified
0.684 0.316 0.000
J98.6 Disorders of diaphragm
0.684 0.316 0.000
J98.5 Diseases of mediastinum, not elsewhere classified
0.684 0.316 0.000
J98.3 Compensatory emphysema
0.684 0.316 0.000
J98.2 Interstitial emphysema
0.684 0.316 0.000
Y43.9 Primarily systemic agent, unspecified
0.684 0.316 0.000
Y43.8 Other primarily systemic agents, not elsewhere classified
0.684 0.316 0.000
Y43.6 Enzymes, not elsewhere classified
0.684 0.316 0.000
Y43.5 Acidifying and alkalising agents
0.684 0.316 0.000
Y43.2 Antineoplastic natural products
0.684 0.316 0.000
Y43.1 Antineoplastic antimetabolites
0.684 0.316 0.000
Y43.0 Antiallergic and antiemetic drugs
0.684 0.316 0.000
O70.3 Fourth degree perineal laceration during delivery
0.684 0.316 0.000
G93.2 Benign intracranial hypertension
0.684 0.316 0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.684 0.316 0.000
O84 Multiple delivery
0.683 0.317 0.000
O83 Other assisted single delivery
0.683 0.317 0.000
O81 Single delivery by forceps and vacuum extractor
0.683 0.317 0.000
Y48.2 Other and unspecified general anaesthetics
0.683 0.317 0.000
T92 Sequelae of injuries of upper limb
0.682 0.318 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.681 0.319 0.000
G95.1 Vascular myelopathies
0.681 0.319 0.000
T83.8 Other complications of genito-urinary prosthetic devices, implants and grafts
0.681 0.319 0.000
I24 Other acute ischaemic heart diseases
0.681 0.319 0.000
O75.6 Delayed delivery after spontaneous or unspecified rupture of membranes
0.680 0.320 0.000
A07 Other protozoal intestinal diseases
0.680 0.320 0.000
A06 Amoebiasis
0.680 0.320 0.000
A05 Other bacterial foodborne intoxications
0.680 0.320 0.000
A03 Shigellosis
0.680 0.320 0.000
A02 Other Salmonella infections
0.680 0.320 0.000
A01 Typhoid and paratyphoid fevers
0.680 0.320 0.000
A00 Cholera
0.680 0.320 0.000
E07.9 Disorder of thyroid, unspecified
0.679 0.321 0.000
J81 Pulmonary oedema
0.678 0.322 0.000
K81 Cholecystitis
0.678 0.322 0.000
G94 Other disorders of brain in diseases classified elsewhere
0.677 0.322 0.000
G90 Disorders of autonomic nervous system
0.677 0.322 0.000
G98 Other disorders of nervous system, not elsewhere classified
0.677 0.322 0.000
G92 Toxic encephalopathy
0.677 0.322 0.000
W00-W19 Falls
0.677 0.323 0.000
B95.5 Unspecified streptococcus as the cause of diseases classified to other chapters
0.677 0.323 0.000
I45 Other conduction disorders
0.677 0.323 0.000
Y54.3 Benzothiadiazine derivatives
0.677 0.323 0.000
S80-S89 Injuries to the knee and lower leg
0.676 0.324 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.675 0.325 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.674 0.325 0.000
L02.4 Cutaneous abscess, furuncle and carbuncle of limb
0.674 0.326 0.000
L08 Other local infections of skin and subcutaneous tissue
0.674 0.326 0.000
B95.2 Streptococcus, group D, as the cause of diseases classified to other chapters
0.674 0.326 0.000
L20-L30 Dermatitis and eczema
0.674 0.326 0.000
N20-N23 Urolithiasis
0.674 0.326 0.000
K82.8 Other specified diseases of gallbladder
0.674 0.326 0.000
S49 Other and unspecified injuries of shoulder and upper arm
0.673 0.326 0.000
S48 Traumatic amputation of shoulder and upper arm
0.673 0.326 0.000
S45 Injury of blood vessels at shoulder and upper arm level
0.673 0.326 0.000
S44 Injury of nerves at shoulder and upper arm level
0.673 0.326 0.000
S47 Crushing injury of shoulder and upper arm
0.673 0.326 0.000
K80.2 Calculus of gallbladder without cholecystitis
0.672 0.328 0.000
S30 Superficial injury of abdomen, lower back and pelvis
0.672 0.328 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.671 0.329 0.000
S46.0 Injury of tendon of the rotator cuff of shoulder
0.671 0.329 0.000
S72.3 Fracture of shaft of femur
0.671 0.329 0.000
C51-C58 Malignant neoplasms of female genital organs
0.671 0.329 0.000
G30-G32 Other degenerative diseases of the nervous system
0.670 0.330 0.000
K80.4 Calculus of bile duct with cholecystitis
0.670 0.330 0.000
S71 Open wound of hip and thigh
0.669 0.330 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.668 0.331 0.000
Q35-Q37 Cleft lip and cleft palate
0.668 0.331 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.668 0.331 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.668 0.331 0.000
Q00-Q07 Congenital malformations of the nervous system
0.668 0.331 0.000
S20-S29 Injuries to the thorax
0.668 0.332 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.667 0.333 0.000
B95.3 Streptococcus pneumoniae as the cause of diseases classified to other chapters
0.666 0.334 0.000
G82.1 Spastic paraplegia
0.666 0.334 0.000
J85 Abscess of lung and mediastinum
0.665 0.334 0.000
J14 Pneumonia due to Haemophilus influenzae
0.664 0.336 0.000
E74.3 Other disorders of intestinal carbohydrate absorption
0.664 0.336 0.000
T85.2 Mechanical complication of intraocular lens
0.663 0.336 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.663 0.337 0.000
S64 Injury of nerves at wrist and hand level
0.662 0.338 0.000
E16 Other disorders of pancreatic internal secretion
0.661 0.338 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.661 0.339 0.000
Y40 Systemic antibiotics
0.661 0.339 0.000
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level
0.660 0.340 0.000
S67 Crushing injury of wrist and hand
0.658 0.342 0.000
S65 Injury of blood vessels at wrist and hand level
0.658 0.342 0.000
O72 Postpartum haemorrhage
0.658 0.342 0.000
B95.1 Streptococcus, group B, as the cause of diseases classified to other chapters
0.657 0.342 0.000
T21 Burn and corrosion of trunk
0.657 0.343 0.000
G93.4 Encephalopathy, unspecified
0.657 0.343 0.000
Q28.2 Arteriovenous malformation of cerebral vessels
0.657 0.343 0.000
T91 Sequelae of injuries of neck and trunk
0.657 0.343 0.000
B99 Other and unspecified infectious diseases
0.657 0.343 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.656 0.343 0.000
O82.9 Delivery by Caesarean section, unspecified
0.656 0.344 0.000
O82.8 Other single delivery by Caesarean section
0.656 0.344 0.000
O82.2 Delivery by Caesarean hysterectomy
0.656 0.344 0.000
G95.9 Disease of spinal cord, unspecified
0.656 0.344 0.000
O75.2 Pyrexia during labour, not elsewhere classified
0.656 0.344 0.000
G80 Infantile cerebral palsy
0.655 0.345 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.654 0.346 0.000
G81.1 Spastic hemiplegia
0.653 0.346 0.000
G81.0 Flaccid hemiplegia
0.653 0.346 0.000
E10 Insulin-dependent diabetes mellitus
0.653 0.347 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.652 0.347 0.000
T23 Burn and corrosion of wrist and hand
0.651 0.349 0.000
J04 Acute laryngitis and tracheitis
0.651 0.349 0.000
T85.1 Mechanical complication of implanted electronic stimulator of nervous system
0.650 0.350 0.000
T85.0 Mechanical complication of ventricular intracranial (communicating) shunt
0.650 0.350 0.000
A04 Other bacterial intestinal infections
0.649 0.351 0.000
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium
0.649 0.351 0.000
T83.0 Mechanical complication of urinary (indwelling) catheter
0.649 0.351 0.000
B95.0 Streptococcus, group A, as the cause of diseases classified to other chapters
0.649 0.351 0.000
S72.00 Fracture of neck of femur (closed)
0.649 0.351 0.000
G62.2 Polyneuropathy due to other toxic agents
0.648 0.351 0.000
G62.1 Alcoholic polyneuropathy
0.648 0.351 0.000
S78 Traumatic amputation of hip and thigh
0.648 0.352 0.000
S77 Crushing injury of hip and thigh
0.648 0.352 0.000
S76 Injury of muscle and tendon at hip and thigh level
0.648 0.352 0.000
S75 Injury of blood vessels at hip and thigh level
0.648 0.352 0.000
S74 Injury of nerves at hip and thigh level
0.648 0.352 0.000
S73 Dislocation, sprain and strain of joint and ligaments of hip
0.648 0.352 0.000
I51 Complications and ill-defined descriptions of heart disease
0.648 0.352 0.000
B95.6 Staphylococcus aureus as the cause of diseases classified to other chapters
0.648 0.352 0.000
S99 Other and unspecified injuries of ankle and foot
0.648 0.352 0.000
S98 Traumatic amputation of ankle and foot
0.648 0.352 0.000
S97 Crushing injury of ankle and foot
0.648 0.352 0.000
S96 Injury of muscle and tendon at ankle and foot level
0.648 0.352 0.000
S95 Injury of blood vessels at ankle and foot level
0.648 0.352 0.000
S94 Injury of nerves at ankle and foot level
0.648 0.352 0.000
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level
0.648 0.352 0.000
E03.8 Other specified hypothyroidism
0.648 0.352 0.000
O69.9 Labour and delivery complicated by cord complication, unspecified
0.647 0.352 0.000
O69.5 Labour and delivery complicated by vascular lesion of cord
0.647 0.352 0.000
O69.4 Labour and delivery complicated by vasa praevia
0.647 0.352 0.000
O69.3 Labour and delivery complicated by short cord
0.647 0.352 0.000
O69.0 Labour and delivery complicated by prolapse of cord
0.647 0.352 0.000
L02.2 Cutaneous abscess, furuncle and carbuncle of trunk
0.648 0.352 0.000
E11.5 With peripheral circulatory complications
0.647 0.353 0.000
S69 Other and unspecified injuries of wrist and hand
0.647 0.353 0.000
K83.0 Cholangitis
0.646 0.354 0.000
B49 Unspecified mycosis
0.645 0.354 0.000
J05 Acute obstructive laryngitis [croup] and epiglottitis
0.645 0.354 0.000
N28.8 Other specified disorders of kidney and ureter
0.645 0.355 0.000
O45 Premature separation of placenta [abruptio placentae]
0.645 0.355 0.000
O43 Placental disorders
0.645 0.355 0.000
O33 Maternal care for known or suspected disproportion
0.645 0.355 0.000
O31 Complications specific to multiple gestation
0.645 0.355 0.000
O40 Polyhydramnios
0.645 0.355 0.000
J01 Acute sinusitis
0.644 0.356 0.000
G83 Other paralytic syndromes
0.644 0.356 0.000
J69.0 Pneumonitis due to food and vomit
0.644 0.356 0.000
O64 Obstructed labour due to malposition and malpresentation of foetus
0.643 0.357 0.000
E12 Malnutrition-related diabetes mellitus
0.643 0.357 0.000
B16 Acute hepatitis B
0.643 0.357 0.000
J00 Acute nasopharyngitis [common cold]
0.642 0.358 0.000
S66 Injury of muscle and tendon at wrist and hand level
0.641 0.359 0.000
J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection
0.638 0.362 0.000
E13 Other specified diabetes mellitus
0.636 0.363 0.000
Q21 Congenital malformations of cardiac septa
0.636 0.364 0.000
O47.9 False labour, unspecified
0.636 0.364 0.000
E04.8 Other specified non-toxic goitre
0.636 0.364 0.000
I00-I02 Acute rheumatic fever
0.635 0.365 0.000
G93.6 Cerebral oedema
0.635 0.365 0.000
V18 Pedal cyclist injured in noncollision transport accident
0.635 0.365 0.000
G63.2 Diabetic polyneuropathy
0.634 0.366 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.634 0.366 0.000
G82.2 Paraplegia, unspecified
0.633 0.367 0.000
Q87 Other specified congenital malformation syndromes affecting multiple systems
0.633 0.367 0.000
I34 Nonrheumatic mitral valve disorders
0.632 0.368 0.000
O66 Other obstructed labour
0.631 0.368 0.000
T83.5 Infection and inflammatory reaction due to prosthetic device, implant and graft in urinary system
0.631 0.369 0.000
N26 Unspecified contracted kidney
0.631 0.369 0.000
G93.8 Other specified disorders of brain
0.630 0.370 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.630 0.370 0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.630 0.370 0.000
S72.2 Subtrochanteric fracture
0.629 0.370 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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