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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2842643
log Bayes Factor = <0.0001
Chromosome 6   position 41,650,736  (GRCh37) Explore rs2842643 on Ensembl!
Variant rs2842643 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
I51 Complications and ill-defined descriptions of heart disease
0.115 0.885 0.000
I34.0 Mitral (valve) insufficiency
0.115 0.885 0.000
I51.8 Other ill-defined heart diseases
0.113 0.887 0.000
I34 Nonrheumatic mitral valve disorders
0.113 0.887 0.000
I30-I52 Other forms of heart disease
0.113 0.887 0.000
I44.1 Atrioventricular block, second degree
0.110 0.890 0.000
I50 Heart failure
0.110 0.890 0.000
I42 Cardiomyopathy
0.109 0.891 0.000
I51.7 Cardiomegaly
0.109 0.891 0.000
I44 Atrioventricular and left bundle-branch block
0.108 0.892 0.000
I42.9 Cardiomyopathy, unspecified
0.107 0.893 0.000
I34.2 Nonrheumatic mitral (valve) stenosis
0.104 0.896 0.000
I44.2 Atrioventricular block, complete
0.104 0.896 0.000
I50.1 Left ventricular failure
0.102 0.898 0.000
I50.0 Congestive heart failure
0.099 0.901 0.000
I51.4 Myocarditis, unspecified
0.095 0.905 0.000
I38 Endocarditis, valve unspecified
0.091 0.909 0.000
I42.8 Other cardiomyopathies
0.091 0.909 0.000
I42.0 Dilated cardiomyopathy
0.090 0.910 0.000
I51.3 Intracardiac thrombosis, not elsewhere classified
0.089 0.911 0.000
I31 Other diseases of pericardium
0.089 0.911 0.000
I31.3 Pericardial effusion (noninflammatory)
0.087 0.913 0.000
I37 Pulmonary valve disorders
0.085 0.915 0.000
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.085 0.915 0.000
I34.8 Other nonrheumatic mitral valve disorders
0.084 0.916 0.000
I42.7 Cardiomyopathy due to drugs and other external agents
0.083 0.916 0.000
I42.1 Obstructive hypertrophic cardiomyopathy
0.083 0.917 0.000
I51.5 Myocardial degeneration
0.083 0.917 0.000
I51.2 Rupture of papillary muscle, not elsewhere classified
0.083 0.917 0.000
I52 Other heart disorders in diseases classified elsewhere
0.081 0.919 0.000
I48 Atrial fibrillation and flutter
0.081 0.919 0.000
I41 Myocarditis in diseases classified elsewhere
0.081 0.919 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.081 0.919 0.000
I32 Pericarditis in diseases classified elsewhere
0.081 0.919 0.000
I51.6 Cardiovascular disease, unspecified
0.081 0.919 0.000
I36 Nonrheumatic tricuspid valve disorders
0.080 0.919 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.080 0.920 0.000
I45 Other conduction disorders
0.080 0.920 0.000
I42.5 Other restrictive cardiomyopathy
0.078 0.921 0.000
I42.3 Endomyocardial (eosinophilic) disease
0.078 0.921 0.000
I40 Acute myocarditis
0.078 0.922 0.000
I44.5 Left posterior fascicular block
0.077 0.922 0.000
I50.9 Heart failure, unspecified
0.077 0.923 0.000
I42.6 Alcoholic cardiomyopathy
0.075 0.925 0.000
I44.4 Left anterior fascicular block
0.074 0.926 0.000
I45.5 Other specified heart block
0.071 0.929 0.000
I51.0 Cardiac septal defect, acquired
0.070 0.930 0.000
I42.4 Endocardial fibroelastosis
0.068 0.932 0.000
I44.3 Other and unspecified atrioventricular block
0.065 0.935 0.000
I37.0 Pulmonary valve stenosis
0.065 0.935 0.000
I31.8 Other specified diseases of pericardium
0.064 0.936 0.000
I31.2 Haemopericardium, not elsewhere classified
0.064 0.936 0.000
I34.9 Nonrheumatic mitral valve disorder, unspecified
0.064 0.936 0.000
I43.0 Cardiomyopathy in infectious and parasitic diseases classified elsewhere
0.063 0.937 0.000
I37.1 Pulmonary valve insufficiency
0.062 0.937 0.000
I33 Acute and subacute endocarditis
0.062 0.938 0.000
I37.9 Pulmonary valve disorder, unspecified
0.061 0.939 0.000
I37.8 Other pulmonary valve disorders
0.061 0.939 0.000
I37.2 Pulmonary valve stenosis with insufficiency
0.061 0.939 0.000
I45.9 Conduction disorder, unspecified
0.061 0.939 0.000
I45.8 Other specified conduction disorders
0.061 0.939 0.000
I45.1 Other and unspecified right bundle-branch block
0.061 0.939 0.000
I45.4 Nonspecific intraventricular block
0.060 0.940 0.000
I31.0 Chronic adhesive pericarditis
0.058 0.942 0.000
I32.8 Pericarditis in other diseases classified elsewhere
0.058 0.942 0.000
I32.1 Pericarditis in other infectious and parasitic diseases classified elsewhere
0.058 0.942 0.000
I32.0 Pericarditis in bacterial diseases classified elsewhere
0.058 0.942 0.000
I39.8 Endocarditis, valve unspecified, in diseases classified elsewhere
0.058 0.942 0.000
I39.4 Multiple valve disorders in diseases classified elsewhere
0.058 0.942 0.000
I39.3 Pulmonary valve disorders in diseases classified elsewhere
0.058 0.942 0.000
I39.2 Tricuspid valve disorders in diseases classified elsewhere
0.058 0.942 0.000
I39.1 Aortic valve disorders in diseases classified elsewhere
0.058 0.942 0.000
I39.0 Mitral valve disorders in diseases classified elsewhere
0.058 0.942 0.000
I41.8 Myocarditis in other diseases classified elsewhere
0.058 0.942 0.000
I41.2 Myocarditis in other infectious and parasitic diseases classified elsewhere
0.058 0.942 0.000
I41.1 Myocarditis in viral diseases classified elsewhere
0.058 0.942 0.000
I41.0 Myocarditis in bacterial diseases classified elsewhere
0.058 0.942 0.000
I48.9 Atrial fibrillation and atrial flutter, unspecified
0.058 0.942 0.000
I48.4 Atypical atrial flutter
0.058 0.942 0.000
I48.3 Typical atrial flutter
0.058 0.942 0.000
I48.2 Chronic atrial fibrillation
0.058 0.942 0.000
I48.1 Persistent atrial fibrillation
0.058 0.942 0.000
I48.0 Paroxysmal atrial fibrillation
0.058 0.942 0.000
I52.8 Other heart disorders in other diseases classified elsewhere
0.058 0.942 0.000
I52.1 Other heart disorders in other infectious and parasitic diseases classified elsewhere
0.058 0.942 0.000
I52.0 Other heart disorders in bacterial diseases classified elsewhere
0.058 0.942 0.000
I36.9 Nonrheumatic tricuspid valve disorder, unspecified
0.058 0.942 0.000
I36.8 Other nonrheumatic tricuspid valve disorders
0.058 0.942 0.000
I36.2 Nonrheumatic tricuspid (valve) stenosis with insufficiency
0.058 0.942 0.000
I36.0 Nonrheumatic tricuspid (valve) stenosis
0.058 0.942 0.000
I40.0 Infective myocarditis
0.058 0.942 0.000
I43.2 Cardiomyopathy in nutritional diseases
0.057 0.942 0.000
I36.1 Nonrheumatic tricuspid (valve) insufficiency
0.057 0.943 0.000
I30 Acute pericarditis
0.057 0.943 0.000
I40.8 Other acute myocarditis
0.056 0.944 0.000
I40.1 Isolated myocarditis
0.056 0.944 0.000
I43.8 Cardiomyopathy in other diseases classified elsewhere
0.056 0.944 0.000
I45.3 Trifascicular block
0.055 0.945 0.000
I44.6 Other and unspecified fascicular block
0.054 0.946 0.000
I45.0 Right fascicular block
0.052 0.948 0.000
I43.1 Cardiomyopathy in metabolic diseases
0.051 0.948 0.000
I40.9 Acute myocarditis, unspecified
0.050 0.950 0.000
I44.0 Atrioventricular block, first degree
0.050 0.950 0.000
I33.9 Acute endocarditis, unspecified
0.047 0.953 0.000
I51.9 Heart disease, unspecified
0.046 0.954 0.000
I31.1 Chronic constrictive pericarditis
0.044 0.956 0.000
I42.2 Other hypertrophic cardiomyopathy
0.041 0.959 0.000
I30.0 Acute nonspecific idiopathic pericarditis
0.041 0.959 0.000
I30.8 Other forms of acute pericarditis
0.040 0.959 0.000
I45.2 Bifascicular block
0.039 0.960 0.000
I30.9 Acute pericarditis, unspecified
0.036 0.964 0.000
I47 Paroxysmal tachycardia
0.034 0.966 0.000
R29.8 Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
0.033 0.967 0.000
I45.6 Preexcitation syndrome
0.033 0.967 0.000
I31.9 Disease of pericardium, unspecified
0.030 0.970 0.000
I34.1 Mitral (valve) prolapse
0.028 0.972 0.000
I30.1 Infective pericarditis
0.028 0.972 0.000
I47.0 Reentry ventricular arrhythmia
0.027 0.973 0.000
I47.9 Paroxysmal tachycardia, unspecified
0.025 0.975 0.000
I46 Cardiac arrest
0.025 0.975 0.000
K90.0 Coeliac disease
0.000 0.977 0.023
I33.0 Acute and subacute infective endocarditis
0.020 0.979 0.000
R03.1 Nonspecific low blood-pressure reading
0.021 0.979 0.000
I08 Multiple valve diseases
0.017 0.983 0.000
I46.1 Sudden cardiac death, so described
0.017 0.983 0.000
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.016 0.984 0.000
I08.0 Disorders of both mitral and aortic valves
0.016 0.984 0.000
I08.2 Disorders of both aortic and tricuspid valves
0.016 0.984 0.000
N39.4 Other specified urinary incontinence
0.000 0.984 0.016
I08.8 Other multiple valve diseases
0.014 0.986 0.000
I08.1 Disorders of both mitral and tricuspid valves
0.013 0.987 0.000
I49 Other cardiac arrhythmias
0.013 0.987 0.000
I08.9 Multiple valve disease, unspecified
0.012 0.988 0.000
I05-I09 Chronic rheumatic heart diseases
0.011 0.989 0.000
I49.1 Atrial premature depolarisation
0.011 0.989 0.000
I49.9 Cardiac arrhythmia, unspecified
0.010 0.990 0.000
R29 Other symptoms and signs involving the nervous and musculoskeletal systems
0.010 0.990 0.000
I05 Rheumatic mitral valve diseases
0.010 0.990 0.000
I47.2 Ventricular tachycardia
0.010 0.990 0.000
I49.4 Other and unspecified premature depolarisation
0.010 0.990 0.000
I49.2 Junctional premature depolarisation
0.009 0.990 0.000
I05.2 Mitral stenosis with insufficiency
0.009 0.991 0.000
S42.20 Fracture of upper end of humerus (closed)
0.000 0.991 0.009
I05.0 Mitral stenosis
0.009 0.991 0.000
I09 Other rheumatic heart diseases
0.008 0.992 0.000
R29.2 Abnormal reflex
0.008 0.992 0.000
I44.7 Left bundle-branch block, unspecified
0.008 0.992 0.000
H61.2 Impacted cerumen
0.008 0.992 0.000
R29.4 Clicking hip
0.008 0.992 0.000
R29.3 Abnormal posture
0.008 0.992 0.000
I05.1 Rheumatic mitral insufficiency
0.008 0.992 0.000
R29.1 Meningismus
0.007 0.993 0.000
D47.2 Monoclonal gammopathy
0.000 0.993 0.007
I06 Rheumatic aortic valve diseases
0.007 0.993 0.000
R29.0 Tetany
0.007 0.993 0.000
I05.8 Other mitral valve diseases
0.007 0.993 0.000
K90 Intestinal malabsorption
0.000 0.993 0.007
I07 Rheumatic tricuspid valve diseases
0.007 0.993 0.000
E10.3 With ophthalmic complications
0.007 0.993 0.000
M80.98 Unspecified osteoporosis with pathological fracture (Other)
0.006 0.994 0.000
E10 Insulin-dependent diabetes mellitus
0.006 0.994 0.000
R29.6 Tendency to fall, not elsewhere classified
0.006 0.994 0.000
E10.4 With neurological complications
0.006 0.994 0.000
I27 Other pulmonary heart diseases
0.006 0.994 0.000
R35 Polyuria
0.000 0.994 0.006
I09.9 Rheumatic heart disease, unspecified
0.006 0.994 0.000
E10.1 With ketoacidosis
0.006 0.994 0.000
I05.9 Mitral valve disease, unspecified
0.006 0.994 0.000
I09.8 Other specified rheumatic heart diseases
0.006 0.994 0.000
I09.2 Chronic rheumatic pericarditis
0.006 0.994 0.000
I09.1 Rheumatic diseases of endocardium, valve unspecified
0.006 0.994 0.000
I09.0 Rheumatic myocarditis
0.006 0.994 0.000
I27.2 Other secondary pulmonary hypertension
0.006 0.994 0.000
I27.0 Primary pulmonary hypertension
0.006 0.994 0.000
Chapter IX Diseases of the circulatory system
0.006 0.994 0.000
I46.9 Cardiac arrest, unspecified
0.006 0.994 0.000
E10.6 With other specified complications
0.006 0.994 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.006 0.994 0.000
E10.5 With peripheral circulatory complications
0.006 0.994 0.000
D37.7 Other digestive organs
0.000 0.994 0.006
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.994 0.006
E10.7 With multiple complications
0.006 0.994 0.000
I06.0 Rheumatic aortic stenosis
0.005 0.994 0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.000 0.994 0.006
E85.9 Amyloidosis, unspecified
0.000 0.995 0.005
I06.2 Rheumatic aortic stenosis with insufficiency
0.005 0.995 0.000
I06.8 Other rheumatic aortic valve diseases
0.005 0.995 0.000
I06.9 Rheumatic aortic valve disease, unspecified
0.005 0.995 0.000
I49.5 Sick sinus syndrome
0.005 0.995 0.000
K90.3 Pancreatic steatorrhoea
0.000 0.995 0.005
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.995 0.005
K90.1 Tropical sprue
0.000 0.995 0.005
M89.97 Disorder of bone, unspecified (Ankle and foot)
0.005 0.995 0.000
I35 Nonrheumatic aortic valve disorders
0.005 0.995 0.000
I07.9 Tricuspid valve disease, unspecified
0.005 0.995 0.000
I07.8 Other tricuspid valve diseases
0.005 0.995 0.000
I07.2 Tricuspid stenosis with insufficiency
0.005 0.995 0.000
I07.0 Tricuspid stenosis
0.005 0.995 0.000
I49.0 Ventricular fibrillation and flutter
0.005 0.995 0.000
I28 Other diseases of pulmonary vessels
0.005 0.995 0.000
E10.2 With renal complications
0.005 0.995 0.000
K90.8 Other intestinal malabsorption
0.000 0.995 0.005
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.000 0.995 0.005
T45.0 Antiallergic and antiemetic drugs
0.000 0.995 0.005
I27.1 Kyphoscoliotic heart disease
0.005 0.995 0.000
T45.2 Vitamins, not elsewhere classified
0.000 0.995 0.005
E85 Amyloidosis
0.000 0.995 0.005
E10.8 With unspecified complications
0.005 0.995 0.000
I27.8 Other specified pulmonary heart diseases
0.005 0.995 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.000 0.995 0.005
E85.4 Organ-limited amyloidosis
0.000 0.995 0.004
I00-I02 Acute rheumatic fever
0.004 0.995 0.000
E85.3 Secondary systemic amyloidosis
0.000 0.996 0.004
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs
0.000 0.996 0.004
I28.8 Other specified diseases of pulmonary vessels
0.004 0.996 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.000 0.996 0.004
I06.1 Rheumatic aortic insufficiency
0.004 0.996 0.001
I28.9 Disease of pulmonary vessels, unspecified
0.004 0.996 0.000
J11.1 Influenza with other respiratory manifestations, virus not identified
0.004 0.996 0.000
S42.2 Fracture of upper end of humerus
0.000 0.996 0.004
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.000 0.996 0.004
I27.9 Pulmonary heart disease, unspecified
0.004 0.996 0.000
E85.8 Other amyloidosis
0.000 0.996 0.004
I46.0 Cardiac arrest with successful resuscitation
0.004 0.996 0.000
E10.0 With coma
0.004 0.996 0.000
K12.1 Other forms of stomatitis
0.004 0.996 0.000
T45.5 Anticoagulants
0.000 0.996 0.004
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.000 0.996 0.004
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.000 0.996 0.004
I28.1 Aneurysm of pulmonary artery
0.004 0.996 0.000
N39.9 Disorder of urinary system, unspecified
0.000 0.996 0.004
T45.1 Antineoplastic and immunosuppressive drugs
0.000 0.996 0.004
T45.9 Primarily systemic and haematological agent, unspecified
0.000 0.996 0.004
T45.8 Other primarily systemic and haematological agents
0.000 0.996 0.004
T45.7 Anticoagulant antagonists, vitamin K and other coagulants
0.000 0.996 0.004
T45.6 Fibrinolysis-affecting drugs
0.000 0.996 0.004
T45.4 Iron and its compounds
0.000 0.996 0.004
T45.3 Enzymes, not elsewhere classified
0.000 0.996 0.004
T46.0 Cardiac-stimulant glycosides and drugs of similar action
0.000 0.996 0.004
T39.0 Salicylates
0.000 0.996 0.004
Z86.3 Personal history of endocrine, nutritional and metabolic diseases
0.004 0.996 0.000
T42.1 Iminostilbenes
0.000 0.996 0.004
T46.5 Other antihypertensive drugs, not elsewhere classified
0.000 0.996 0.004
R03 Abnormal blood-pressure reading, without diagnosis
0.004 0.996 0.000
I28.0 Arteriovenous fistula of pulmonary vessels
0.003 0.996 0.000
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.996 0.004
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.996 0.004
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.996 0.004
T51.9 Alcohol, unspecified
0.000 0.996 0.004
T46.3 Coronary vasodilators, not elsewhere classified
0.000 0.996 0.003
T46.2 Other antidysrhythmic drugs, not elsewhere classified
0.000 0.996 0.003
T36 Poisoning by systemic antibiotics
0.000 0.996 0.004
T46.8 Antivaricose drugs, including sclerosing agents
0.000 0.996 0.003
T46.7 Peripheral vasodilators
0.000 0.996 0.003
I02 Rheumatic chorea
0.003 0.996 0.000
I01 Rheumatic fever with heart involvement
0.003 0.996 0.000
T46.9 Other and unspecified agents primarily affecting the cardiovascular system
0.000 0.997 0.003
M46.92 Inflammatory spondylopathy, unspecified (Cervical region)
0.003 0.997 0.000
T42.3 Barbiturates
0.000 0.997 0.003
T47.1 Other antacids and anti-gastric-secretion drugs
0.000 0.997 0.003
T46.1 Calcium-channel blockers
0.000 0.997 0.003
M80.9 Unspecified osteoporosis with pathological fracture
0.003 0.997 0.000
T47.4 Other laxatives
0.000 0.997 0.003
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.000 0.997 0.003
Z40.0 Prophylactic surgery for risk-factors related to malignant neoplasms
0.003 0.997 0.000
I00 Rheumatic fever without mention of heart involvement
0.003 0.997 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.000 0.997 0.003
T38.6 Antigonadotrophins. antioestrogens, antiandrogens, not elsewhere classified
0.000 0.997 0.003
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.000 0.997 0.003
T38.1 Thyroid hormones and substitutes
0.000 0.997 0.003
I07.1 Tricuspid insufficiency
0.003 0.997 0.000
S42.21 Fracture of upper end of humerus (open)
0.000 0.997 0.003
T38.9 Other and unspecified hormone antagonists
0.000 0.997 0.003
T38.7 Androgens and anabolic congeners
0.000 0.997 0.003
T38.5 Other oestrogens and progestogens
0.000 0.997 0.003
T38.4 Oral contraceptives
0.000 0.997 0.003
T38.2 Antithyroid drugs
0.000 0.997 0.003
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants
0.000 0.997 0.003
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.000 0.997 0.003
T42.0 Hydantoin derivatives
0.000 0.997 0.003
T38.0 Glucocorticoids and synthetic analogues
0.000 0.997 0.003
T47.6 Antidiarrhoeal drugs
0.000 0.997 0.003
D04.7 Skin of lower limb, including hip
0.000 0.997 0.003
T36.3 Macrolides
0.000 0.997 0.003
N39 Other disorders of urinary system
0.000 0.997 0.003
E55.9 Vitamin D deficiency, unspecified
0.003 0.997 0.000
T42.5 Mixed antiepileptics, not elsewhere classified
0.000 0.997 0.003
T42.2 Succinimides and oxazolidinediones
0.000 0.997 0.003
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.000 0.997 0.003
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified
0.000 0.997 0.003
T47.8 Other agents primarily affecting the gastro-intestinal system
0.000 0.997 0.003
T47.7 Emetics
0.000 0.997 0.003
T47.5 Digestants
0.000 0.997 0.003
T47.3 Saline and osmotic laxatives
0.000 0.997 0.003
S52.60 Fracture of lower end of both ulna and radius (closed)
0.000 0.997 0.003
T47.2 Stimulant laxatives
0.000 0.997 0.003
I26 Pulmonary embolism
0.003 0.997 0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified
0.000 0.997 0.003
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.000 0.997 0.003
M89.94 Disorder of bone, unspecified (Hand)
0.003 0.997 0.000
I49.8 Other specified cardiac arrhythmias
0.003 0.997 0.000
K12.3 Oral mucositis (ulcerative)
0.003 0.997 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.000 0.997 0.003
M89.9 Disorder of bone, unspecified
0.003 0.997 0.000
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics
0.000 0.997 0.003
N39.1 Persistent proteinuria, unspecified
0.000 0.997 0.003
T36.4 Tetracyclines
0.000 0.997 0.003
T36.1 Cefalosporins and other Beta-lactam antibiotics
0.000 0.997 0.003
T38.8 Other and unspecified hormones and their synthetic substitutes
0.000 0.997 0.003
J35.1 Hypertrophy of tonsils
0.000 0.997 0.003
T36.9 Systemic antibiotic, unspecified
0.000 0.997 0.003
T36.7 Antifungal antibiotics, systemically used
0.000 0.997 0.003
T36.6 Rifamycins
0.000 0.997 0.003
T36.5 Aminoglycosides
0.000 0.997 0.003
T36.2 Chloramphenicol group
0.000 0.997 0.003
T47.0 Histamine H(2)-receptor antagonists
0.000 0.997 0.003
M80.90 Unspecified osteoporosis with pathological fracture (Multiple sites)
0.003 0.997 0.000
T36.8 Other systemic antibiotics
0.000 0.997 0.003
I01.9 Acute rheumatic heart disease, unspecified
0.002 0.997 0.000
I01.8 Other acute rheumatic heart disease
0.002 0.997 0.000
I01.2 Acute rheumatic myocarditis
0.002 0.997 0.000
I01.1 Acute rheumatic endocarditis
0.002 0.997 0.000
I01.0 Acute rheumatic pericarditis
0.002 0.997 0.000
I02.9 Rheumatic chorea without heart involvement
0.002 0.997 0.000
I02.0 Rheumatic chorea with heart involvement
0.002 0.997 0.000
I35.8 Other aortic valve disorders
0.003 0.997 0.000
T36.0 Penicillins
0.000 0.997 0.003
H11.0 Pterygium
0.003 0.997 0.000
T50.9 Other and unspecified drugs, medicaments and biological substances
0.000 0.997 0.003
T50.6 Antidotes and chelating agents, not elsewhere classified
0.000 0.997 0.003
M80.97 Unspecified osteoporosis with pathological fracture (Ankle and foot)
0.003 0.997 0.000
M80.96 Unspecified osteoporosis with pathological fracture (Lower leg)
0.003 0.997 0.000
M80.94 Unspecified osteoporosis with pathological fracture (Hand)
0.003 0.997 0.000
M80.93 Unspecified osteoporosis with pathological fracture (Forearm)
0.003 0.997 0.000
M80.92 Unspecified osteoporosis with pathological fracture (Upper arm)
0.003 0.997 0.000
M80.91 Unspecified osteoporosis with pathological fracture (Shoulder region)
0.003 0.997 0.000
T50.7 Analeptics and opioid receptor antagonists
0.000 0.997 0.003
T50.5 Appetite depressants
0.000 0.997 0.003
T50.3 Electrolytic, caloric and water-balance agents
0.000 0.997 0.003
T50.1 Loop [high-ceiling] diuretics
0.000 0.997 0.003
T50.0 Mineralocorticoids and their antagonists
0.000 0.997 0.003
T41.5 Therapeutic gases
0.000 0.997 0.002
T41.4 Anaesthetic, unspecified
0.000 0.997 0.002
T41.3 Local anaesthetics
0.000 0.997 0.002
T41.2 Other and unspecified general anaesthetics
0.000 0.997 0.002
T41.1 Intravenous anaesthetics
0.000 0.997 0.002
T41.0 Inhaled anaesthetics
0.000 0.997 0.002
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.000 0.997 0.003
T48.5 Anti-common-cold drugs
0.000 0.997 0.002
T48.7 Other and unspecified agents primarily acting on the respiratory system
0.000 0.997 0.002
T48.4 Expectorants
0.000 0.997 0.002
T48.3 Antitussives
0.000 0.997 0.002
T48.2 Other and unspecified agents primarily acting on muscles
0.000 0.997 0.002
T48.1 Skeletal muscle relaxants [neuromuscular blocking agents]
0.000 0.997 0.002
T48.0 Oxytocic drugs
0.000 0.997 0.002
M80.95 Unspecified osteoporosis with pathological fracture (Pelvic region and thigh)
0.002 0.997 0.000
T49.9 Topical agent, unspecified
0.000 0.997 0.002
T49.8 Other topical agents
0.000 0.997 0.002
T49.7 Dental drugs, topically applied
0.000 0.997 0.002
T49.6 Otorhinolaryngological drugs and preparations
0.000 0.997 0.002
T49.5 Ophthalmological drugs and preparations
0.000 0.997 0.002
T49.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations
0.000 0.997 0.002
T49.3 Emollients, demulcents and protectants
0.000 0.997 0.002
T49.2 Local astringents and local detergents
0.000 0.997 0.002
T49.1 Antipruritics
0.000 0.997 0.002
T50.4 Drugs affecting uric acid metabolism
0.000 0.997 0.002
C54.1 Endometrium
0.000 0.997 0.003
T40.6 Other and unspecified narcotics
0.000 0.997 0.003
N39.2 Orthostatic proteinuria, unspecified
0.000 0.997 0.002
R63.0 Anorexia
0.003 0.997 0.000
T48.6 Antiasthmatics, not elsewhere classified
0.000 0.997 0.002
T37.9 Systemic anti-infective and antiparasitic, unspecified
0.000 0.998 0.002
T37.5 Antiviral drugs
0.000 0.998 0.002
T37.4 Anthelminthics
0.000 0.998 0.002
T37.3 Other antiprotozoal drugs
0.000 0.998 0.002
T37.2 Antimalarials and drugs acting on other blood protozoa
0.000 0.998 0.002
T37.1 Antimycobacterial drugs
0.000 0.998 0.002
T37.0 Sulphonamides
0.000 0.998 0.002
T49.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified
0.000 0.998 0.002
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified
0.000 0.998 0.002
M25.47 Effusion of joint (Ankle and foot)
0.000 0.998 0.002
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.000 0.998 0.002
S02.30 Fracture of orbital floor (closed)
0.002 0.998 0.000
T50.8 Diagnostic agents
0.000 0.998 0.002
I35.9 Aortic valve disorder, unspecified
0.002 0.998 0.000
M34.9 Systemic sclerosis, unspecified
0.002 0.998 0.000
T46.4 Angiotensin-converting-enzyme inhibitors
0.000 0.998 0.002
K12 Stomatitis and related lesions
0.002 0.998 0.000
T39.4 Antirheumatics, not elsewhere classified
0.000 0.998 0.002
T39.2 Pyrazolone derivatives
0.000 0.998 0.002
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified
0.000 0.998 0.002
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified
0.000 0.998 0.002
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified
0.000 0.998 0.002
T44.2 Ganglionic blocking drugs, not elsewhere classified
0.000 0.998 0.002
T44.1 Other parasympathomimetics [cholinergics]
0.000 0.998 0.002
T44.0 Anticholinesterase agents
0.000 0.998 0.002
M89.99 Disorder of bone, unspecified (Site unspecified)
0.002 0.998 0.000
M89.95 Disorder of bone, unspecified (Pelvic region and thigh)
0.002 0.998 0.000
M89.90 Disorder of bone, unspecified (Multiple sites)
0.002 0.998 0.000
I26.0 Pulmonary embolism with mention of acute cor pulmonale
0.002 0.998 0.000
H50.1 Divergent concomitant strabismus
0.002 0.998 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.000 0.998 0.002
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.000 0.998 0.002
M89.85 Other specified disorders of bone (Pelvic region and thigh)
0.002 0.998 0.000
T42.4 Benzodiazepines
0.000 0.998 0.002
M80.99 Unspecified osteoporosis with pathological fracture (Site unspecified)
0.002 0.998 0.000
O80.9 Single spontaneous delivery, unspecified
0.000 0.998 0.002
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified
0.000 0.998 0.002
M89.91 Disorder of bone, unspecified (Shoulder region)
0.002 0.998 0.000
T44.9 Other and unspecified drugs primarily affecting the nervous system
0.000 0.998 0.002
H61 Other disorders of external ear
0.002 0.998 0.000
M89.96 Disorder of bone, unspecified (Lower leg)
0.002 0.998 0.000
T37.8 Other specified systemic anti-infectives and antiparasitics
0.000 0.998 0.002
K90.9 Intestinal malabsorption, unspecified
0.001 0.998 0.001
T43.9 Psychotropic drug, unspecified
0.000 0.998 0.002
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.000 0.998 0.002
K45.8 Other specified abdominal hernia without obstruction or gangrene
0.002 0.998 0.000
M93.9 Osteochondropathy, unspecified
0.000 0.998 0.002
T43.3 Phenothiazine antipsychotics and neuroleptics
0.000 0.998 0.002
M89.98 Disorder of bone, unspecified (Other)
0.002 0.998 0.000
M34.8 Other forms of systemic sclerosis
0.002 0.998 0.000
L50.0 Allergic urticaria
0.000 0.998 0.002
I15.9 Seconday hypertension, unspecified
0.002 0.998 0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.000 0.998 0.002
Z89.0 Acquired absence of finger(s) [including thumb], unilateral
0.002 0.998 0.000
M21.67 Other acquired deformities of ankle and foot-Ankle/foot
0.002 0.998 0.000
L50.9 Urticaria, unspecified
0.000 0.998 0.002
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified
0.000 0.998 0.002
Z92.1 Personal history of long-term (current) use of anticoagulants
0.002 0.998 0.000
I15 Secondary hypertension
0.002 0.998 0.000
J11 Influenza, virus not identified
0.002 0.998 0.000
I35.2 Aortic (valve) stenosis with insufficiency
0.002 0.998 0.000
Q89.2 Congenital malformations of other endocrine glands
0.002 0.998 0.000
T40.9 Other and unspecified psychodysleptics [hallucinogens]
0.000 0.998 0.002
T40.8 Lysergide [LSD]
0.000 0.998 0.002
T40.7 Cannabis (derivatives)
0.000 0.998 0.002
T40.0 Opium
0.000 0.998 0.002
T78.2 Anaphylactic shock, unspecified
0.000 0.998 0.002
M89.93 Disorder of bone, unspecified (Forearm)
0.002 0.998 0.000
T40.3 Methadone
0.000 0.998 0.002
I10-I15 Hypertensive diseases
0.002 0.998 0.000
T40.5 Cocaine
0.000 0.998 0.002
T40.1 Heroin
0.000 0.998 0.002
I70.00 Atherosclerosis of aorta (without gangrene)
0.002 0.998 0.000
M47.99 Spondylosis, unspecified (Site unspecified)
0.000 0.998 0.002
S12.20 Fracture of other specified cervical vertebra (closed)
0.002 0.998 0.000
M46.97 Inflammatory spondylopathy, unspecified (Lumbosacral region)
0.002 0.998 0.000
M89.8 Other specified disorders of bone
0.002 0.998 0.000
T43.8 Other psychotropic drugs, not elsewhere classified
0.000 0.998 0.002
M89.92 Disorder of bone, unspecified (Upper arm)
0.002 0.998 0.000
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
0.002 0.998 0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.000 0.998 0.002
M89 Other disorders of bone
0.002 0.998 0.000
M34 Systemic sclerosis
0.002 0.998 0.000
M46.46 Discitis, unspecified (Lumbar region)
0.002 0.998 0.000
H61.1 Non-infective disorders of pinna
0.002 0.998 0.000
I22.1 Subsequent myocardial infarction of inferior wall
0.002 0.998 0.000
I15.1 Hypertension secondary to other renal disorders
0.002 0.998 0.000
R17 Unspecified jaundice
0.002 0.998 0.000
M81.98 Osteoporosis, unspecified (Other)
0.000 0.998 0.002
I65.2 Occlusion and stenosis of carotid artery
0.002 0.998 0.000
K12.0 Recurrent oral aphthae
0.002 0.998 0.000
M89.0 Algoneurodystrophy
0.002 0.998 0.000
M89.83 Other specified disorders of bone (Forearm)
0.002 0.998 0.000
M34.0 Progressive systemic sclerosis
0.002 0.998 0.000
M46.9 Inflammatory spondylopathy, unspecified
0.002 0.998 0.000
I49.3 Ventricular premature depolarisation
0.001 0.998 0.001
T43.6 Psychostimulants with abuse potential
0.000 0.998 0.002
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.000 0.998 0.002
M25.42 Effusion of joint (Upper arm)
0.000 0.998 0.002
J11.8 Influenza with other manifestations, virus not identified
0.002 0.998 0.000
M46.98 Inflammatory spondylopathy, unspecified (Sacral and sacrococcygeal region)
0.002 0.998 0.000
J11.0 Influenza with pneumonia, virus not identified
0.002 0.998 0.000
I15.8 Other secondary hypertension
0.002 0.998 0.000
I15.2 Hypertension secondary to endocrine disorders
0.002 0.998 0.000
I98.2 Oesophageal varices in diseases classified elsewhere
0.000 0.998 0.002
M25.45 Effusion of joint (Pelvic region and thigh)
0.000 0.998 0.002
M89.07 Algoneurodystrophy (Ankle and foot)
0.002 0.998 0.000
M89.84 Other specified disorders of bone (Hand)
0.002 0.998 0.000
C44.2 Skin of ear and external auricular canal
0.000 0.998 0.002
D37.1 Stomach
0.000 0.998 0.002
I13 Hypertensive heart and renal disease
0.002 0.998 0.000
I20.9 Angina pectoris, unspecified
0.002 0.998 0.000
I70.0 Atherosclerosis of aorta
0.002 0.998 0.000
M89.09 Algoneurodystrophy (Site unspecified)
0.002 0.998 0.000
C80.9 Malignant neoplasm, unspecified
0.002 0.998 0.000
M89.82 Other specified disorders of bone (Upper arm)
0.002 0.998 0.000
M89.80 Other specified disorders of bone (Multiple sites)
0.002 0.998 0.000
M34.1 CR(E)ST syndrome
0.002 0.998 0.000
M89.04 Algoneurodystrophy (Hand)
0.002 0.998 0.000
M89.89 Other specified disorders of bone (Site unspecified)
0.002 0.998 0.000
M89.87 Other specified disorders of bone (Ankle and foot)
0.002 0.998 0.000
H61.0 Perichondritis of external ear
0.002 0.998 0.000
I15.0 Renovascular hypertension
0.001 0.998 0.000
M89.6 Osteopathy after poliomyelitis
0.002 0.998 0.000
M89.2 Other disorders of bone development and growth
0.002 0.998 0.000
M89.1 Epiphyseal arrest
0.002 0.998 0.000
I70.20 Atherosclerosis of arteries of extremities (without gangrene)
0.002 0.998 0.000
M80.52 Idiopathic osteoporosis with pathological fracture (Upper arm)
0.002 0.998 0.000
M34.2 Systemic sclerosis induced by drugs and chemicals
0.001 0.998 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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