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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2844670
log Bayes Factor = 55.6631
Chromosome 6   position 31,005,726  (GRCh37) Explore rs2844670 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E78.0 Pure hypercholesterolaemia
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.000 1.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.003 0.997
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.003 0.997
E70-E90 Metabolic disorders
0.000 0.004 0.996
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.007 0.993
I25.2 Old myocardial infarction
0.000 0.009 0.991
E10.3 With ophthalmic complications
0.000 0.009 0.991
E14 Unspecified diabetes mellitus
0.000 0.014 0.986
E78.5 Hyperlipidaemia, unspecified
0.000 0.019 0.981
L40 Psoriasis
0.000 0.021 0.979
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.026 0.974
I24 Other acute ischaemic heart diseases
0.000 0.036 0.964
E14.9 Without complications
0.000 0.040 0.960
I21 Acute myocardial infarction
0.000 0.041 0.959
E10.1 With ketoacidosis
0.000 0.049 0.951
I25.5 Ischaemic cardiomyopathy
0.000 0.057 0.943
L40.5 Arthropathic psoriasis
0.000 0.067 0.933
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.074 0.926
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.076 0.924
E78.2 Mixed hyperlipidaemia
0.000 0.079 0.921
I21.9 Acute myocardial infarction, unspecified
0.000 0.090 0.910
E11.1 With ketoacidosis
0.000 0.096 0.904
E05.9 Thyrotoxicosis, unspecified
0.000 0.097 0.903
E78.8 Other disorders of lipoprotein metabolism
0.000 0.100 0.900
E11.0 With coma
0.000 0.103 0.897
I24.8 Other forms of acute ischaemic heart disease
0.000 0.111 0.889
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.122 0.878
E14.3 With ophthalmic complications
0.000 0.127 0.873
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.136 0.864
E10.8 With unspecified complications
0.000 0.143 0.857
L40-L45 Papulosquamous disorders
0.000 0.150 0.850
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.155 0.845
I25.3 Aneurysm of heart
0.000 0.157 0.843
E07 Other disorders of thyroid
0.000 0.162 0.838
E10.0 With coma
0.000 0.163 0.837
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.168 0.832
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.170 0.830
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.176 0.824
E74 Other disorders of carbohydrate metabolism
0.000 0.177 0.823
I21.4 Acute subendocardial myocardial infarction
0.000 0.184 0.816
E10.4 With neurological complications
0.000 0.185 0.815
G35-G37 Demyelinating diseases of the central nervous system
0.814 0.186 0.000
I23 Certain current complications following acute myocardial infarction
0.000 0.188 0.812
L40.0 Psoriasis vulgaris
0.000 0.190 0.810
L43 Lichen planus
0.000 0.193 0.807
I22 Subsequent myocardial infarction
0.000 0.193 0.807
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.198 0.802
E40-E46 Malnutrition
0.000 0.207 0.793
E78.4 Other hyperlipidaemia
0.000 0.213 0.787
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.216 0.784
L43.9 Lichen planus, unspecified
0.000 0.220 0.780
L40.8 Other psoriasis
0.000 0.224 0.775
G37 Other demyelinating diseases of central nervous system
0.774 0.226 0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.227 0.773
E10.6 With other specified complications
0.000 0.236 0.764
E13 Other specified diabetes mellitus
0.000 0.238 0.762
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.239 0.761
E07.9 Disorder of thyroid, unspecified
0.000 0.243 0.757
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.248 0.752
E14.4 With neurological complications
0.000 0.249 0.751
E78.1 Pure hyperglyceridaemia
0.000 0.251 0.749
E03.8 Other specified hypothyroidism
0.000 0.252 0.748
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.253 0.747
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.253 0.746
E11.6 With other specified complications
0.000 0.262 0.738
E16 Other disorders of pancreatic internal secretion
0.000 0.265 0.735
K90 Intestinal malabsorption
0.000 0.267 0.733
E10.5 With peripheral circulatory complications
0.000 0.267 0.733
G37.9 Demyelinating disease of central nervous system, unspecified
0.727 0.273 0.000
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.273 0.727
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.277 0.723
E89.3 Postprocedural hypopituitarism
0.000 0.278 0.722
E10.7 With multiple complications
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E78.6 Lipoprotein deficiency
0.000 0.283 0.717
E78.3 Hyperchylomicronaemia
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.1 Congenital hypothyroidism without goitre
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
E10.2 With renal complications
0.000 0.283 0.716
E79 Disorders of purine and pyrimidine metabolism
0.000 0.286 0.714
E77 Disorders of glycoprotein metabolism
0.000 0.286 0.714
E76 Disorders of glycosaminoglycan metabolism
0.000 0.286 0.714
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.286 0.714
E72 Other disorders of amino-acid metabolism
0.000 0.286 0.714
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.286 0.714
E70 Disorders of aromatic amino-acid metabolism
0.000 0.286 0.714
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.286 0.714
E14.6 With other specified complications
0.000 0.291 0.709
E14.8 With unspecified complications
0.000 0.293 0.707
E14.7 With multiple complications
0.000 0.293 0.707
E14.2 Withrenal complications
0.000 0.293 0.707
E14.0 With coma
0.000 0.293 0.707
L40.4 Guttate psoriasis
0.000 0.298 0.702
L40.2 Acrodermatitis continua
0.000 0.298 0.702
I20 Angina pectoris
0.000 0.300 0.700
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.302 0.698
E14.1 With ketoacidosis
0.000 0.302 0.698
I10 Essential (primary) hypertension
0.000 0.303 0.697
I10-I15 Hypertensive diseases
0.000 0.304 0.696
L40.1 Generalised pustular psoriasis
0.000 0.305 0.695
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.312 0.688
Chapter IX Diseases of the circulatory system
0.000 0.316 0.684
I23.8 Other current complications following acute myocardial infarction
0.000 0.321 0.679
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.324 0.676
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.326 0.674
E84 Cystic fibrosis
0.000 0.331 0.669
I20.9 Angina pectoris, unspecified
0.000 0.331 0.669
E14.5 With peripheral circulatory complications
0.000 0.332 0.668
E85 Amyloidosis
0.000 0.333 0.667
E05.5 Thyroid crisis or storm
0.000 0.336 0.664
E05.4 Thyrotoxicosis factitia
0.000 0.336 0.664
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.336 0.664
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.336 0.664
E50-E64 Other nutritional deficiencies
0.000 0.340 0.660
I12 Hypertensive renal disease
0.000 0.346 0.654
E11.5 With peripheral circulatory complications
0.000 0.354 0.646
E46 Unspecified protein-energy malnutrition
0.000 0.356 0.644
L42 Pityriasis rosea
0.000 0.366 0.634
I24.1 Dressler's syndrome
0.000 0.371 0.629
G37.8 Other specified demyelinating diseases of central nervous system
0.623 0.377 0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.383 0.617
E05.8 Other thyrotoxicosis
0.000 0.387 0.613
L44 Other papulosquamous disorders
0.000 0.390 0.610
L41 Parapsoriasis
0.000 0.390 0.610
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.390 0.610
I25.4 Coronary artery aneurysm
0.000 0.391 0.609
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.393 0.607
E15 Nondiabetic hypoglycaemic coma
0.000 0.394 0.606
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.396 0.603
E89.2 Postprocedural hypoparathyroidism
0.000 0.398 0.602
E07.1 Dyshormogenetic goitre
0.000 0.399 0.601
E07.0 Hypersecretion of calcitonin
0.000 0.399 0.601
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.399 0.601
E16.1 Other hypoglycaemia
0.000 0.401 0.598
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.402 0.598
E13.9 Without complications
0.000 0.408 0.592
M06 Other rheumatoid arthritis
0.000 0.408 0.592
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.410 0.590
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.410 0.590
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.410 0.590
E74.2 Disorders of galactose metabolism
0.000 0.410 0.590
E74.1 Disorders of fructose metabolism
0.000 0.410 0.590
E74.0 Glycogen storage disease
0.000 0.410 0.590
I12.9 Hypertensive renal disease without renal failure
0.000 0.411 0.589
G36 Other acute disseminated demyelination
0.583 0.417 0.000
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.418 0.582
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.418 0.582
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.418 0.582
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.418 0.582
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.418 0.582
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.418 0.582
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.418 0.582
L43.3 Subacute (active) lichen planus
0.000 0.421 0.579
L43.2 Lichenoid drug reaction
0.000 0.421 0.579
L43.1 Bullous lichen planus
0.000 0.421 0.579
L43.0 Hypertrophic lichen planus
0.000 0.421 0.579
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.422 0.578
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.578 0.422 0.000
E11.8 With unspecified complications
0.000 0.422 0.578
E73 Lactose intolerance
0.000 0.422 0.578
E11.4 With neurological complications
0.000 0.423 0.577
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.425 0.575
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.425 0.575
E89.5 Postprocedural testicular hypofunction
0.000 0.425 0.575
E89.1 Postprocedural hypoinsulinaemia
0.000 0.425 0.575
E16.2 Hypoglycaemia, unspecified
0.000 0.427 0.573
E06 Thyroiditis
0.000 0.427 0.573
K90.9 Intestinal malabsorption, unspecified
0.000 0.428 0.572
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.432 0.568
E45 Retarded development following protein-energy malnutrition
0.000 0.432 0.568
E43 Unspecified severe protein-energy malnutrition
0.000 0.432 0.568
E42 Marasmic kwashiorkor
0.000 0.432 0.568
E41 Nutritional marasmus
0.000 0.432 0.568
E40 Kwashiorkor
0.000 0.432 0.568
I30-I52 Other forms of heart disease
0.000 0.432 0.568
L40.3 Pustulosis palmaris et plantaris
0.000 0.434 0.566
I12.0 Hypertensive renal disease with renal failure
0.000 0.434 0.566
E89.4 Postprocedural ovarian failure
0.000 0.434 0.566
G37.5 Concentric sclerosis [Balo]
0.555 0.445 0.000
G37.4 Subacute necrotising myelitis
0.555 0.445 0.000
G37.2 Central pontine myelinolysis
0.555 0.445 0.000
G37.1 Central demyelination of corpus callosum
0.555 0.445 0.000
G37.0 Diffuse sclerosis
0.555 0.445 0.000
E61 Deficiency of other nutrient elements
0.000 0.446 0.554
I15 Secondary hypertension
0.000 0.447 0.553
L43.8 Other lichen planus
0.000 0.448 0.552
E13.8 With unspecified complications
0.000 0.453 0.546
E13.7 With multiple complications
0.000 0.453 0.546
E13.6 With other specified complications
0.000 0.453 0.546
E13.5 With peripheral circulatory complications
0.000 0.453 0.546
E13.4 With neurological complications
0.000 0.453 0.546
E13.3 With ophthalmic complications
0.000 0.453 0.546
E13.2 With renal complications
0.000 0.453 0.546
E13.1 With ketoacidosis
0.000 0.453 0.546
E13.0 With coma
0.000 0.453 0.546
I44 Atrioventricular and left bundle-branch block
0.000 0.455 0.545
E83 Disorders of mineral metabolism
0.363 0.458 0.179
I46 Cardiac arrest
0.000 0.464 0.536
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.473 0.527
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.473 0.527
E16.4 Abnormal secretion of gastrin
0.000 0.473 0.527
E16.3 Increased secretion of glucagon
0.000 0.473 0.527
I51 Complications and ill-defined descriptions of heart disease
0.000 0.474 0.526
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.474 0.526
K90.3 Pancreatic steatorrhoea
0.000 0.474 0.526
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.474 0.526
K90.1 Tropical sprue
0.000 0.474 0.526
I46.9 Cardiac arrest, unspecified
0.000 0.474 0.526
E11.2 With renal complications
0.000 0.479 0.521
E88 Other metabolic disorders
0.000 0.482 0.518
I44.0 Atrioventricular block, first degree
0.000 0.484 0.516
I45 Other conduction disorders
0.000 0.484 0.516
K90.8 Other intestinal malabsorption
0.000 0.484 0.516
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.488 0.512
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.488 0.512
E70.3 Albinism
0.000 0.488 0.512
E70.2 Disorders of tyrosine metabolism
0.000 0.488 0.512
E70.1 Other hyperphenylalaninaemias
0.000 0.488 0.512
E70.0 Classical phenylketonuria
0.000 0.488 0.512
E71.3 Disorders of fatty-acid metabolism
0.000 0.488 0.512
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.488 0.512
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.488 0.512
E71.0 Maple-syrup-urine disease
0.000 0.488 0.512
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.488 0.512
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.488 0.512
E72.5 Disorders of glycine metabolism
0.000 0.488 0.512
E72.4 Disorders of ornithine metabolism
0.000 0.488 0.512
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.488 0.512
E72.2 Disorders of urea cycle metabolism
0.000 0.488 0.512
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.488 0.512
E72.0 Disorders of amino-acid transport
0.000 0.488 0.512
E75.6 Lipid storage disorder, unspecified
0.000 0.488 0.512
E75.5 Other lipid storage disorders
0.000 0.488 0.512
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.488 0.512
E75.3 Sphingolipidosis, unspecified
0.000 0.488 0.512
E75.2 Other sphingolipidosis
0.000 0.488 0.512
E75.1 Other gangliosidosis
0.000 0.488 0.512
E75.0 GM2 gangliosidosis
0.000 0.488 0.512
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.488 0.512
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.488 0.512
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.488 0.512
E76.2 Other mucopolysaccharidoses
0.000 0.488 0.512
E76.1 Mucopolysaccharidosis, type II
0.000 0.488 0.512
E76.0 Mucopolysaccharidosis, type I
0.000 0.488 0.512
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.488 0.512
E77.8 Other disorders of glycoprotein metabolism
0.000 0.488 0.512
E77.1 Defects in glycoprotein degradation
0.000 0.488 0.512
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.488 0.512
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.488 0.512
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.488 0.512
E79.1 Lesch-Nyhan syndrome
0.000 0.488 0.512
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.488 0.512
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.491 0.509
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.498 0.502
E85.4 Organ-limited amyloidosis
0.000 0.499 0.501
I45.1 Other and unspecified right bundle-branch block
0.000 0.500 0.500
E07.8 Other specified disorders of thyroid
0.000 0.500 0.500
I13 Hypertensive heart and renal disease
0.000 0.501 0.499
I44.7 Left bundle-branch block, unspecified
0.000 0.505 0.495
I00-I02 Acute rheumatic fever
0.000 0.509 0.490
I51.8 Other ill-defined heart diseases
0.000 0.511 0.489
I22.8 Subsequent myocardial infarction of other sites
0.000 0.518 0.481
M06.3 Rheumatoid nodule
0.000 0.519 0.481
E84.8 Cystic fibrosis with other manifestations
0.000 0.520 0.480
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.520 0.480
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.520 0.480
E85.8 Other amyloidosis
0.000 0.521 0.478
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.521 0.478
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.521 0.478
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.521 0.478
E20-E35 Disorders of other endocrine glands
0.000 0.525 0.475
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.526 0.473
E63 Other nutritional deficiencies
0.000 0.526 0.473
E56 Other vitamin deficiencies
0.000 0.526 0.473
E51 Thiamine deficiency
0.000 0.526 0.473
E50 Vitamin A deficiency
0.000 0.526 0.473
E60 Dietary zinc deficiency
0.000 0.526 0.473
E59 Dietary selenium deficiency
0.000 0.526 0.473
E58 Dietary calcium deficiency
0.000 0.526 0.473
E54 Ascorbic acid deficiency
0.000 0.526 0.473
E52 Niacin deficiency [pellagra]
0.000 0.526 0.473
E61.1 Iron deficiency
0.000 0.528 0.472
I47 Paroxysmal tachycardia
0.000 0.534 0.466
E85.9 Amyloidosis, unspecified
0.000 0.534 0.465
I51.9 Heart disease, unspecified
0.000 0.536 0.464
I44.3 Other and unspecified atrioventricular block
0.000 0.542 0.457
I51.0 Cardiac septal defect, acquired
0.000 0.544 0.456
M06.4 Inflammatory polyarthropathy
0.000 0.548 0.452
I11 Hypertensive heart disease
0.000 0.550 0.450
E55 Vitamin D deficiency
0.000 0.551 0.449
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.556 0.444
I15.9 Seconday hypertension, unspecified
0.000 0.562 0.438
L41.9 Parapsoriasis, unspecified
0.000 0.563 0.437
L41.8 Other parapsoriasis
0.000 0.563 0.437
L41.5 Retiform parapsoriasis
0.000 0.563 0.437
L41.4 Large plaque parapsoriasis
0.000 0.563 0.437
L41.3 Small plaque parapsoriasis
0.000 0.563 0.437
L41.2 Lymphomatoid papulosis
0.000 0.563 0.437
L41.1 Pityriasis lichenoides chronica
0.000 0.563 0.437
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.563 0.437
L44.9 Papulosquamous disorder, unspecified
0.000 0.563 0.437
L44.8 Other specified papulosquamous disorders
0.000 0.563 0.437
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.563 0.437
L44.3 Lichen ruber moniliformis
0.000 0.563 0.437
L44.2 Lichen striatus
0.000 0.563 0.437
L44.1 Lichen nitidus
0.000 0.563 0.437
L44.0 Pityriasis rubra pilaris
0.000 0.563 0.437
E84.9 Cystic fibrosis, unspecified
0.000 0.565 0.434
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.569 0.431
E80.5 Crigler-Najjar syndrome
0.000 0.569 0.431
E80.3 Defects of catalase and peroxydase
0.000 0.569 0.431
E80.2 Other porphyria
0.000 0.569 0.431
E80.1 Porphyria cutanea tarda
0.000 0.569 0.431
E80.0 Hereditary erythropoietic porphyria
0.000 0.569 0.431
E80.6 Other disorders of bilirubin metabolism
0.000 0.570 0.430
I51.6 Cardiovascular disease, unspecified
0.000 0.574 0.426
I45.8 Other specified conduction disorders
0.000 0.576 0.424
M06.8 Other specified rheumatoid arthritis
0.000 0.576 0.424
M06.2 Rheumatoid bursitis
0.000 0.576 0.424
M06.1 Adult-onset Still's disease
0.000 0.576 0.424
I44.6 Other and unspecified fascicular block
0.000 0.577 0.423
I45.2 Bifascicular block
0.000 0.581 0.419
G36.9 Acute disseminated demyelination, unspecified
0.418 0.581 0.000
G36.8 Other specified acute disseminated demyelination
0.418 0.581 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.418 0.581 0.000
G36.0 Neuromyelitis optica [Devic]
0.418 0.581 0.000
I47.9 Paroxysmal tachycardia, unspecified
0.000 0.582 0.418
E85.3 Secondary systemic amyloidosis
0.000 0.583 0.417
I20.1 Angina pectoris with documented spasm
0.000 0.585 0.415
E73.8 Other lactose intolerance
0.000 0.586 0.414
E73.1 Secondary lactase deficiency
0.000 0.586 0.414
E73.0 Congenital lactase deficiency
0.000 0.586 0.414
I15.1 Hypertension secondary to other renal disorders
0.000 0.588 0.412
E06.5 Other chronic thyroiditis
0.000 0.589 0.411
E06.4 Drug-induced thyroiditis
0.000 0.589 0.411
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.589 0.411
E06.1 Subacute thyroiditis
0.000 0.589 0.411
E06.0 Acute thyroiditis
0.000 0.589 0.411
E44.1 Mild protein-energy malnutrition
0.000 0.592 0.407
E44.0 Moderate protein-energy malnutrition
0.000 0.592 0.407
I52 Other heart disorders in diseases classified elsewhere
0.000 0.593 0.407
I48 Atrial fibrillation and flutter
0.000 0.593 0.407
I43 Cardiomyopathy in diseases classified elsewhere
0.000 0.593 0.407
I41 Myocarditis in diseases classified elsewhere
0.000 0.593 0.407
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.000 0.593 0.407
I32 Pericarditis in diseases classified elsewhere
0.000 0.593 0.407
E61.2 Magnesium deficiency
0.000 0.593 0.407
I44.4 Left anterior fascicular block
0.000 0.595 0.405
M06.34 Rheumatoid nodule (Hand)
0.000 0.601 0.399
I47.2 Ventricular tachycardia
0.000 0.601 0.399
I45.3 Trifascicular block
0.000 0.602 0.398
E61.9 Deficiency of nutrient element, unspecified
0.000 0.603 0.397
E61.8 Deficiency of other specified nutrient elements
0.000 0.603 0.397
E61.7 Deficiency of multiple nutrient elements
0.000 0.603 0.397
E61.6 Vanadium deficiency
0.000 0.603 0.397
E61.5 Molybdenum deficiency
0.000 0.603 0.397
E61.4 Chromium deficiency
0.000 0.603 0.397
E61.3 Manganese deficiency
0.000 0.603 0.397
E61.0 Copper deficiency
0.000 0.603 0.397
I15.8 Other secondary hypertension
0.000 0.604 0.396
I15.2 Hypertension secondary to endocrine disorders
0.000 0.604 0.396
I15.0 Renovascular hypertension
0.000 0.604 0.396
K51 Ulcerative colitis
0.395 0.604 0.000
E29 Testicular dysfunction
0.000 0.608 0.392
E24 Cushing's syndrome
0.000 0.609 0.391
I44.5 Left posterior fascicular block
0.000 0.609 0.391
K51.9 Ulcerative colitis, unspecified
0.390 0.610 0.000
E83.9 Disorder of mineral metabolism, unspecified
0.260 0.611 0.129
E83.8 Other disorders of mineral metabolism
0.260 0.611 0.129
E83.2 Disorders of zinc metabolism
0.260 0.611 0.129
E83.0 Disorders of copper metabolism
0.260 0.611 0.129
I46.1 Sudden cardiac death, so described
0.000 0.615 0.384
I37 Pulmonary valve disorders
0.000 0.619 0.381
I20.8 Other forms of angina pectoris
0.000 0.621 0.379
I51.5 Myocardial degeneration
0.000 0.623 0.377
I51.2 Rupture of papillary muscle, not elsewhere classified
0.000 0.623 0.377
K51.3 Ulcerative (chronic) rectosigmoiditis
0.377 0.623 0.000
I31 Other diseases of pericardium
0.000 0.624 0.376
E88.2 Lipomatosis, not elsewhere classified
0.000 0.627 0.373
I36 Nonrheumatic tricuspid valve disorders
0.000 0.628 0.372
I95-I99 Other and unspecified disorders of the circulatory system
0.000 0.628 0.372
E88.9 Metabolic disorder, unspecified
0.000 0.629 0.371
E88.8 Other specified metabolic disorders
0.000 0.629 0.371
I45.0 Right fascicular block
0.000 0.630 0.370
E06.9 Thyroiditis, unspecified
0.000 0.632 0.368
I35 Nonrheumatic aortic valve disorders
0.000 0.635 0.365
I51.3 Intracardiac thrombosis, not elsewhere classified
0.000 0.637 0.363
E83.3 Disorders of phosphorus metabolism
0.285 0.640 0.075
I40 Acute myocarditis
0.000 0.640 0.360
K51.5 Mucosal proctocolitis
0.360 0.640 0.000
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.000 0.641 0.359
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.642 0.358
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.642 0.358
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.642 0.358
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.642 0.358
K51.8 Other ulcerative colitis
0.356 0.644 0.000
M05-M14 Inflammatory polyarthropathies
0.000 0.645 0.355
E28 Ovarian dysfunction
0.000 0.645 0.355
I02 Rheumatic chorea
0.000 0.648 0.352
I01 Rheumatic fever with heart involvement
0.000 0.648 0.352
I00 Rheumatic fever without mention of heart involvement
0.000 0.648 0.352
E22 Hyperfunction of pituitary gland
0.000 0.649 0.351
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.650 0.350
K51.4 Pseudopolyposis of colon
0.350 0.650 0.000
E65-E68 Obesity and other hyperalimentation
0.000 0.652 0.348
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.655 0.345
M06.38 Rheumatoid nodule (Other)
0.000 0.655 0.345
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.655 0.345
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.655 0.345
M06.33 Rheumatoid nodule (Forearm)
0.000 0.655 0.345
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.655 0.345
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.655 0.345
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.655 0.345
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.656 0.344
I45.9 Conduction disorder, unspecified
0.000 0.656 0.344
I45.5 Other specified heart block
0.000 0.657 0.342
I30 Acute pericarditis
0.000 0.658 0.342
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.659 0.341
E32 Diseases of thymus
0.000 0.659 0.341
E31 Polyglandular dysfunction
0.000 0.659 0.341
E30 Disorders of puberty, not elsewhere classified
0.000 0.659 0.341
E25 Adrenogenital disorders
0.000 0.659 0.341
I42 Cardiomyopathy
0.000 0.660 0.340
E88.3 Tumour lysis syndrome
0.000 0.660 0.340
E50.9 Vitamin A deficiency, unspecified
0.000 0.660 0.339
E50.8 Other manifestations of vitamin A deficiency
0.000 0.660 0.339
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.660 0.339
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.660 0.339
E50.5 Vitamin A deficiency with night blindness
0.000 0.660 0.339
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.660 0.339
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.660 0.339
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.660 0.339
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.660 0.339
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.660 0.339
E51.9 Thiamine deficiency, unspecified
0.000 0.660 0.339
E51.8 Other manifestations of thiamine deficiency
0.000 0.660 0.339
E51.2 Wernicke's encephalopathy
0.000 0.660 0.339
E51.1 Beriberi
0.000 0.660 0.339
E56.9 Vitamin deficiency, unspecified
0.000 0.660 0.339
E56.8 Deficiency of other vitamins
0.000 0.660 0.339
E56.1 Deficiency of vitamin K
0.000 0.660 0.339
E56.0 Deficiency of vitamin E
0.000 0.660 0.339
E63.9 Nutritional deficiency, unspecified
0.000 0.660 0.339
E63.8 Other specified nutritional deficiencies
0.000 0.660 0.339
E63.1 Imbalance of constituents of food intake
0.000 0.660 0.339
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.660 0.339
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.660 0.339
E64.8 Sequelae of other nutritional deficiencies
0.000 0.660 0.339
E64.3 Sequelae of rickets
0.000 0.660 0.339
E64.2 Sequelae of vitamin C deficiency
0.000 0.660 0.339
E64.1 Sequelae of vitamin A deficiency
0.000 0.660 0.339
E64.0 Sequelae of protein-energy malnutrition
0.000 0.660 0.339
E23 Hypofunction and other disorders of pituitary gland
0.000 0.664 0.336
K51.2 Ulcerative (chronic) proctitis
0.335 0.665 0.000
E29.1 Testicular hypofunction
0.000 0.667 0.333
I47.0 Reentry ventricular arrhythmia
0.000 0.667 0.333
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.667 0.332

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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