TreeWAS – Variant ID: rs2859631

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability
M54.5 Low back pain	0.078	0.922
M54.59 Low back pain (Site unspecified)	0.077	0.923
M54 Dorsalgia	0.076	0.924
M54.2 Cervicalgia	0.069	0.931
M54.56 Low back pain (Lumbar region)	0.068	0.932
M50-M54 Other dorsopathies	0.065	0.935
M54.58 Low back pain (Sacral and sacrococcygeal region)	0.065	0.935
M54.22 Cervicalgia (Cervical region)	0.063	0.937
M54.3 Sciatica	0.062	0.938
M54.6 Pain in thoracic spine	0.059	0.941
M54.50 Low back pain (Multiple sites in spine)	0.058	0.942
M25 Other joint disorders, not elsewhere classified	0.057	0.943
M54.4 Lumbago with sciatica	0.057	0.943
M54.52 Low back pain-Cervical	0.056	0.943
M54.8 Other dorsalgia	0.056	0.944
M54.53 Low back pain-Cervicothoracic	0.056	0.944
M54.51 Low back pain-Occipit-atl-axl	0.056	0.944
M54.55 Low back pain (Thoracolumbar region)	0.056	0.944
M20-M25 Other joint disorders	0.056	0.944
M25.5 Pain in joint	0.055	0.945
M54.54 Low back pain-Thoracic	0.055	0.945
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.055	0.945
M54.0 Panniculitis affecting regions of neck and back	0.054	0.945
M54.57 Low back pain (Lumbosacral region)	0.053	0.947
M50 Cervical disk disorders	0.052	0.948
M25.4 Effusion of joint	0.052	0.948
M54.1 Radiculopathy	0.051	0.949
M54.29 Cervicalgia-Site unspe	0.050	0.949
M54.28 Cervicalgia-Sacral/sacrococ	0.050	0.950
M54.21 Cervicalgia (Occipito-atlanto-axial region)	0.050	0.950
M25.55 Pain in joint (Pelvic region and thigh)	0.049	0.951
M54.27 Cervicalgia-Lumbosacral	0.049	0.951
M54.26 Cervicalgia-Lumbar	0.049	0.951
M54.25 Cervicalgia-Thoracolumbar	0.049	0.951
M54.24 Cervicalgia-Thoracic	0.049	0.951
M54.20 Cervicalgia-Mult site	0.049	0.951
M54.39 Sciatica (Site unspecified)	0.049	0.951
M23 Internal derangement of knee	0.049	0.951
M54.9 Dorsalgia, unspecified	0.049	0.951
M54.23 Cervicalgia (Cervicothoracic region)	0.049	0.951
M24 Other specific joint derangements	0.048	0.952
M54.38 Sciatica (Sacral and sacrococcygeal region)	0.047	0.953
M25.51 Pain in joint (Shoulder region)	0.047	0.953
M54.37 Sciatica (Lumbosacral region)	0.047	0.953
M05-M14 Inflammatory polyarthropathies	0.047	0.953
M54.64 Pain in thoracic spine (Thoracic region)	0.046	0.954
M53 Other dorsopathies, not elsewhere classified	0.046	0.954
M25.7 Osteophyte	0.046	0.954
M34 Systemic sclerosis	0.046	0.954
M25.54 Pain in joint (Hand)	0.045	0.954
M54.30 Sciatica (Multiple sites in spine)	0.045	0.955
M51 Other intervertebral disk disorders	0.045	0.955
M91-M94 Chondropathies	0.045	0.955
M54.35 Sciatica (Thoracolumbar region)	0.045	0.955
M54.34 Sciatica-Thoracic	0.045	0.955
M54.33 Sciatica-Cervicothoracic	0.045	0.955
M54.32 Sciatica-Cervical	0.045	0.955
M54.31 Sciatica-Occipit-atl-axl	0.045	0.955
M25.8 Other specified joint disorders	0.044	0.956
M60-M63 Disorders of muscles	0.044	0.956
M13 Other arthritis	0.044	0.956
M45-M49 Spondylopathies	0.044	0.956
M50.1 Cervical disk disorder with radiculopathy	0.044	0.956
M54.36 Sciatica (Lumbar region)	0.043	0.957
M23.2 Derangement of meniscus due to old tear or injury	0.043	0.957
M25.46 Effusion of joint (Lower leg)	0.043	0.957
M54.65 Pain in thoracic spine (Thoracolumbar region)	0.043	0.957
M54.63 Pain in thoracic spine (Cervicothoracic region)	0.043	0.957
M54.47 Lumbago with sciatica (Lumbosacral region)	0.043	0.957
M25.6 Stiffness of joint, not elsewhere classified	0.042	0.957
M30 Polyarteritis nodosa and related conditions	0.042	0.958
M31 Other necrotising vasculopathies	0.042	0.958
M00-M03 Infectious arthropathies	0.042	0.958
M54.69 Pain in thoracic spine-Site unspe	0.042	0.958
M54.68 Pain in thoracic spine-Sacral/sacrococ	0.042	0.958
M54.67 Pain in thoracic spine-Lumbosacral	0.042	0.958
M54.66 Pain in thoracic spine-Lumbar	0.042	0.958
M54.62 Pain in thoracic spine-Cervical	0.042	0.958
M54.61 Pain in thoracic spine-Occipit-atl-axl	0.042	0.958
M54.60 Pain in thoracic spine (Multiple sites in spine)	0.042	0.958
M13.9 Arthritis, unspecified	0.042	0.958
M25.9 Joint disorder, unspecified	0.042	0.958
M25.52 Pain in joint (Upper arm)	0.042	0.958
M54.46 Lumbago with sciatica (Lumbar region)	0.042	0.958
M50.3 Other cervical disk degeneration	0.041	0.958
M54.86 Other dorsalgia (Lumbar region)	0.041	0.958
M25.2 Flail joint	0.041	0.959
M25.1 Fistula of joint	0.041	0.959
M54.16 Radiculopathy (Lumbar region)	0.041	0.959
M54.80 Other dorsalgia (Multiple sites in spine)	0.041	0.959
M54.88 Other dorsalgia (Sacral and sacrococcygeal region)	0.041	0.959
M54.48 Lumbago with sciatica (Sacral and sacrococcygeal region)	0.041	0.959
M54.45 Lumbago with sciatica (Thoracolumbar region)	0.041	0.959
M54.44 Lumbago with sciatica-Thoracic	0.041	0.959
M54.43 Lumbago with sciatica-Cervicothoracic	0.041	0.959
M54.42 Lumbago with sciatica-Cervical	0.041	0.959
M54.41 Lumbago with sciatica-Occipit-atl-axl	0.041	0.959
M54.40 Lumbago with sciatica (Multiple sites in spine)	0.041	0.959
M54.87 Other dorsalgia (Lumbosacral region)	0.041	0.959
M54.89 Other dorsalgia (Site unspecified)	0.041	0.959
M25.50 Pain in joint (Multiple sites)	0.041	0.959
M54.49 Lumbago with sciatica (Site unspecified)	0.041	0.959
M54.85 Other dorsalgia (Thoracolumbar region)	0.040	0.959
M54.83 Other dorsalgia (Cervicothoracic region)	0.040	0.959
M54.82 Other dorsalgia (Cervical region)	0.040	0.959
M54.81 Other dorsalgia (Occipito-atlanto-axial region)	0.040	0.959
M24.1 Other articular cartilage disorders	0.040	0.960
M25.47 Effusion of joint (Ankle and foot)	0.040	0.960
M33 Dermatopolymyositis	0.040	0.960
M32 Systemic lupus erythematosus	0.040	0.960
M25.53 Pain in joint (Forearm)	0.040	0.960
M13.90 Arthritis, unspecified (Multiple sites)	0.040	0.960
M25.56 Pain in joint (Lower leg)	0.040	0.960
M23.4 Loose body in knee	0.040	0.960
M65-M68 Disorders of synovium and tendon	0.040	0.960
M25.45 Effusion of joint (Pelvic region and thigh)	0.040	0.960
M54.84 Other dorsalgia (Thoracic region)	0.039	0.960
M25.3 Other instability of joint	0.039	0.960
M54.12 Radiculopathy (Cervical region)	0.039	0.961
M54.09 Panniculitis affecting regions of neck and back (Site unspecified)	0.039	0.961
M54.08 Panniculitis affecting regions of neck and back (Sacral and sacrococcygeal region)	0.039	0.961
M54.07 Panniculitis affecting regions of neck and back (Lumbosacral region)	0.039	0.961
M54.06 Panniculitis affecting regions of neck and back (Lumbar region)	0.039	0.961
M54.05 Panniculitis affecting regions of neck and back (Thoracolumbar region)	0.039	0.961
M54.04 Panniculitis affecting regions of neck and back (Thoracic region)	0.039	0.961
M54.03 Panniculitis affecting regions of neck and back (Cervicothoracic region)	0.039	0.961
M54.02 Panniculitis affecting regions of neck and back (Cervical region)	0.039	0.961
M54.01 Panniculitis affecting regions of neck and back (Occipito-atlanto-axial region)	0.039	0.961
M54.00 Panniculitis affecting regions of neck and back (Multiple sites in spine)	0.039	0.961
M50.9 Cervical disk disorder, unspecified	0.039	0.961
M25.58 Pain in joint (Other)	0.039	0.961
M35 Other systemic involvement of connective tissue	0.039	0.961
M24.8 Other specific joint derangements, not elsewhere classified	0.039	0.961
M23.20 Derangement of meniscus due to old tear or injury (Multiple sites)	0.039	0.961
M25.40 Effusion of joint (Multiple sites)	0.039	0.961
M25.77 Osteophyte (Ankle and foot)	0.039	0.961
M25.43 Effusion of joint (Forearm)	0.039	0.961
M25.59 Pain in joint (Site unspecified)	0.038	0.962
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.038	0.962
M25.44 Effusion of joint (Hand)	0.038	0.962
M50.8 Other cervical disk disorders	0.038	0.962
M23.0 Cystic meniscus	0.038	0.962
M24.2 Disorder of ligament	0.038	0.962
M23.26 Derangement of meniscus due to old tear or injury (Other and unspecified lateral meniscus)	0.038	0.962
M25.41 Effusion of joint (Shoulder region)	0.038	0.962
M54.14 Radiculopathy (Thoracic region)	0.038	0.962
M23.8 Other internal derangements of knee	0.038	0.962
M54.98 Dorsalgia, unspecified (Sacral and sacrococcygeal region)	0.038	0.962
M25.0 Haemarthrosis	0.037	0.962
M50.0 Cervical disk disorder with myelopathy	0.037	0.962
M07 Psoriatic and enteropathic arthropathies	0.037	0.962
M54.13 Radiculopathy (Cervicothoracic region)	0.037	0.963
M25.49 Effusion of joint (Site unspecified)	0.037	0.963
M25.48 Effusion of joint (Other)	0.037	0.963
M25.71 Osteophyte (Shoulder region)	0.037	0.963
M54.15 Radiculopathy (Thoracolumbar region)	0.037	0.963
M54.11 Radiculopathy (Occipito-atlanto-axial region)	0.037	0.963
M05 Seropositive rheumatoid arthritis	0.037	0.963
M40-M43 Deforming dorsopathies	0.037	0.963
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.037	0.963
M54.92 Dorsalgia, unspecified (Cervical region)	0.037	0.963
M54.18 Radiculopathy (Sacral and sacrococcygeal region)	0.036	0.963
M25.57 Pain in joint (Ankle and foot)	0.036	0.963
M54.96 Dorsalgia, unspecified (Lumbar region)	0.036	0.964
M54.95 Dorsalgia, unspecified (Thoracolumbar region)	0.036	0.964
M34.9 Systemic sclerosis, unspecified	0.036	0.964
M47 Spondylosis	0.036	0.964
M54.10 Radiculopathy (Multiple sites in spine)	0.036	0.964
M23.6 Other spontaneous disruption of ligament(s) of knee	0.036	0.964
M54.90 Dorsalgia, unspecified (Multiple sites in spine)	0.036	0.964
M54.93 Dorsalgia, unspecified (Cervicothoracic region)	0.036	0.964
M94 Other disorders of cartilage	0.036	0.964
M23.1 Discoid meniscus (congenital)	0.036	0.964
M53.3 Sacrococcygeal disorders, not elsewhere classified	0.036	0.964
M34.1 CR(E)ST syndrome	0.036	0.964
M62 Other disorders of muscle	0.036	0.964
M51.2 Other specified intervertebral disk displacement	0.036	0.964
M13.94 Arthritis, unspecified (Hand)	0.036	0.964
M25.42 Effusion of joint (Upper arm)	0.035	0.964
M24.9 Joint derangement, unspecified	0.035	0.964
M25.78 Osteophyte (Other)	0.035	0.964
M24.6 Ankylosis of joint	0.035	0.964
M24.5 Contracture of joint	0.035	0.964
M54.91 Dorsalgia, unspecified (Occipito-atlanto-axial region)	0.035	0.965
M92 Other juvenile osteochondrosis	0.035	0.965
M54.97 Dorsalgia, unspecified (Lumbosacral region)	0.035	0.965
M23.25 Derangement of meniscus due to old tear or injury (Posterior horn of lateral meniscus)	0.035	0.965
M13.98 Arthritis, unspecified (Other)	0.035	0.965
M24.4 Recurrent dislocation and subluxation of joint	0.034	0.965
M23.9 Internal derangement of knee, unspecified	0.034	0.966
M12 Other specific arthropathies	0.034	0.966
M53.9 Dorsopathy, unspecified	0.034	0.966
M45 Ankylosing spondylitis	0.034	0.966
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.034	0.966
M51.9 Intervertebral disk disorder, unspecified	0.034	0.966
M13.95 Arthritis, unspecified (Pelvic region and thigh)	0.034	0.966
M25.79 Osteophyte (Site unspecified)	0.034	0.966
M24.7 Protrusio acetabuli	0.034	0.966
M13.93 Arthritis, unspecified (Forearm)	0.034	0.966
M13.91 Arthritis, unspecified (Shoulder region)	0.034	0.966
M09 Juvenile arthritis in diseases classified elsewhere	0.034	0.966
M24.16 Other articular cartilage disorders (Lower leg)	0.034	0.966
M70-M79 Other soft tissue disorders	0.034	0.966
M34.0 Progressive systemic sclerosis	0.033	0.966
M34.8 Other forms of systemic sclerosis	0.033	0.966
M25.86 Other specified joint disorders (Lower leg)	0.033	0.967
M13.0 Polyarthritis, unspecified	0.033	0.967
M22 Disorders of patella	0.033	0.967
M53.1 Cervicobrachial syndrome	0.033	0.967
M53.0 Cervicocranial syndrome	0.033	0.967
M25.88 Other specified joint disorders (Other)	0.033	0.967
M23.22 Derangement of meniscus due to old tear or injury (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.033	0.967
M25.70 Osteophyte (Multiple sites)	0.033	0.967
M34.2 Systemic sclerosis induced by drugs and chemicals	0.033	0.967
M00 Pyogenic arthritis	0.033	0.967
M25.85 Other specified joint disorders (Pelvic region and thigh)	0.033	0.967
M80-M85 Disorders of bone density and structure	0.033	0.967
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)	0.033	0.967
M60 Myositis	0.033	0.967
M91 Juvenile osteochondrosis of hip and pelvis	0.033	0.967
M51.1 Lumbar and other intervertebral disk disorders with radiculopathy	0.033	0.967
M30.1 Polyarteritis with lung involvement [Churg-Strauss]	0.033	0.967
M25.87 Other specified joint disorders (Ankle and foot)	0.033	0.967
M51.8 Other specified intervertebral disk disorders	0.032	0.967
M25.72 Osteophyte (Upper arm)	0.032	0.967
M65 Synovitis and tenosynovitis	0.033	0.967
M25.73 Osteophyte (Forearm)	0.032	0.967
M25.82 Other specified joint disorders (Upper arm)	0.032	0.967
M54.19 Radiculopathy (Site unspecified)	0.032	0.967
M46 Other inflammatory spondylopathies	0.032	0.967
M08 Juvenile arthritis	0.032	0.968
M25.83 Other specified joint disorders (Forearm)	0.032	0.968
M47.9 Spondylosis, unspecified	0.032	0.968
M25.76 Osteophyte (Lower leg)	0.032	0.968
M54.94 Dorsalgia, unspecified (Thoracic region)	0.032	0.968
M24.0 Loose body in joint	0.032	0.968
M31.6 Other giant cell arteritis	0.032	0.968
M25.89 Other specified joint disorders (Site unspecified)	0.032	0.968
M25.80 Other specified joint disorders (Multiple sites)	0.032	0.968
M11 Other crystal arthropathies	0.032	0.968
M23.5 Chronic instability of knee	0.032	0.968
M14 Arthropathies in other diseases classified elsewhere	0.032	0.968
M63 Disorders of muscle in diseases classified elsewhere	0.032	0.968
M61 Calcification and ossification of muscle	0.032	0.968
M23.24 Derangement of meniscus due to old tear or injury (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.032	0.968
M13.8 Other specified arthritis	0.032	0.968
M93 Other osteochondropathies	0.032	0.968
M25.81 Other specified joint disorders (Shoulder region)	0.031	0.968
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)	0.031	0.968
M25.94 Joint disorder, unspecified (Hand)	0.031	0.968
M25.63 Stiffness of joint, not elsewhere classified (Forearm)	0.031	0.968
M25.95 Joint disorder, unspecified (Pelvic region and thigh)	0.031	0.968
M23.3 Other meniscus derangements	0.032	0.968
M35.0 Sicca syndrome [Sjogren]	0.031	0.968
M25.60 Stiffness of joint, not elsewhere classified (Multiple sites)	0.031	0.969
M31.9 Necrotising vasculopathy, unspecified	0.031	0.969
M53.8 Other specified dorsopathies	0.031	0.969
M31.0 Hypersensitivity angiitis	0.031	0.969
M51.3 Other specified intervertebral disk degeneration	0.031	0.969
M23.27 Derangement of meniscus due to old tear or injury-Capsular	0.031	0.969
M25.65 Stiffness of joint, not elsewhere classified (Pelvic region and thigh)	0.031	0.969
M31.1 Thrombotic microangiopathy	0.031	0.969
M07.3 Other psoriatic arthropathies	0.031	0.969
M23.49 Loose body in knee-Unspec lig/men	0.031	0.969
M31.8 Other specified necrotising vasculopathies	0.031	0.969
M05.9 Seropositive rheumatoid arthritis, unspecified	0.031	0.969
M31.4 Aortic arch syndrome [Takayasu]	0.031	0.969
M13.1 Monoarthritis, not elsewhere classified	0.031	0.969
M02 Reactive arthropathies	0.031	0.969
M25.99 Joint disorder, unspecified (Site unspecified)	0.031	0.969
M30.8 Other conditions related to polyarteritis nodosa	0.031	0.969
M24.15 Other articular cartilage disorders (Pelvic region and thigh)	0.031	0.969
M24.86 Other specific joint derangements, not elsewhere classified (Lower leg)	0.031	0.969
M13.92 Arthritis, unspecified (Upper arm)	0.031	0.969
M24.13 Other articular cartilage disorders (Forearm)	0.031	0.969
M25.92 Joint disorder, unspecified (Upper arm)	0.031	0.969
M25.69 Stiffness of joint, not elsewhere classified (Site unspecified)	0.031	0.969
M25.90 Joint disorder, unspecified (Multiple sites)	0.031	0.969
M25.98 Joint disorder, unspecified (Other)	0.031	0.969
M30.3 Mucocutaneous lymph node syndrome [Kawasaki]	0.031	0.969
M30.2 Juvenile polyarteritis	0.031	0.969
M31.2 Lethal midline granuloma	0.031	0.969
M25.84 Other specified joint disorders (Hand)	0.031	0.969
M03 Postinfective and reactive arthropathies in diseases classified elsewhere	0.031	0.969
M01 Direct infections of joint in infectious and parasitic diseases classified elsewhere	0.031	0.969
M30.0 Polyarteritis nodosa	0.030	0.969
M25.62 Stiffness of joint, not elsewhere classified (Upper arm)	0.030	0.969
M54.17 Radiculopathy (Lumbosacral region)	0.030	0.969
M53.2 Spinal instabilities	0.030	0.969
M25.91 Joint disorder, unspecified (Shoulder region)	0.030	0.970
M25.61 Stiffness of joint, not elsewhere classified (Shoulder region)	0.030	0.970
M24.85 Other specific joint derangements, not elsewhere classified (Pelvic region and thigh)	0.030	0.970
M51.0 Lumbar and other intervertebral disk disorders with myelopathy	0.030	0.970
M51.4 Schmorl's nodes	0.030	0.970
M23.43 Loose body in knee-Med lig/oth men	0.030	0.970
M25.75 Osteophyte (Pelvic region and thigh)	0.030	0.970
M31.3 Wegener's granulomatosis	0.030	0.970
M35.1 Other overlap syndromes	0.030	0.970
M31.5 Giant cell arteritis with polymyalgia rheumatica	0.030	0.970
M94.8 Other specified disorders of cartilage	0.030	0.970
M31.7 Microscopic polyangiitis	0.030	0.970
M25.19 Fistula of joint (Site unspecified)	0.030	0.970
M25.18 Fistula of joint (Other)	0.030	0.970
M25.17 Fistula of joint (Ankle and foot)	0.030	0.970
M25.16 Fistula of joint (Lower leg)	0.030	0.970
M25.15 Fistula of joint (Pelvic region and thigh)	0.030	0.970
M25.14 Fistula of joint (Hand)	0.030	0.970
M25.13 Fistula of joint (Forearm)	0.030	0.970
M25.12 Fistula of joint (Upper arm)	0.030	0.970
M25.11 Fistula of joint (Shoulder region)	0.030	0.970
M25.10 Fistula of joint (Multiple sites)	0.030	0.970
M25.29 Flail joint (Site unspecified)	0.030	0.970
M25.28 Flail joint (Other)	0.030	0.970
M25.27 Flail joint (Ankle and foot)	0.030	0.970
M25.26 Flail joint (Lower leg)	0.030	0.970
M25.25 Flail joint (Pelvic region and thigh)	0.030	0.970
M25.24 Flail joint (Hand)	0.030	0.970
M25.23 Flail joint (Forearm)	0.030	0.970
M25.22 Flail joint (Upper arm)	0.030	0.970
M25.21 Flail joint (Shoulder region)	0.030	0.970
M25.20 Flail joint (Multiple sites)	0.030	0.970
M25.36 Other instability of joint (Lower leg)	0.030	0.970
M23.46 Loose body in knee-O/unsp lat men	0.030	0.970
M25.68 Stiffness of joint, not elsewhere classified (Other)	0.030	0.970
M33.1 Other dermatomyositis	0.030	0.970
M25.93 Joint disorder, unspecified (Forearm)	0.029	0.970
M49 Spondylopathies in diseases classified elsewhere	0.030	0.970
M24.23 Disorder of ligament (Forearm)	0.029	0.970
M25.97 Joint disorder, unspecified (Ankle and foot)	0.029	0.970
M24.14 Other articular cartilage disorders (Hand)	0.029	0.970
M24.26 Disorder of ligament (Lower leg)	0.029	0.970
M32.8 Other forms of systemic lupus erythematosus	0.029	0.970
M25.96 Joint disorder, unspecified (Lower leg)	0.029	0.971
M33.9 Dermatopolymyositis, unspecified	0.029	0.971
M23.41 Loose body in knee-Ant lig/hrn men	0.029	0.971
M32.0 Drug-induced systemic lupus erythematosus	0.029	0.971
M23.06 Cystic meniscus (Other and unspecified lateral meniscus)	0.029	0.971
M35.2 Behcet's disease	0.029	0.971
M24.19 Other articular cartilage disorders (Site unspecified)	0.029	0.971
M24.18 Other articular cartilage disorders (Other)	0.029	0.971
M24.12 Other articular cartilage disorders (Upper arm)	0.029	0.971
M24.10 Other articular cartilage disorders (Multiple sites)	0.029	0.971
M23.44 Loose body in knee-Lat lig/ant men	0.029	0.971
M24.84 Other specific joint derangements, not elsewhere classified (Hand)	0.029	0.971
M33.0 Juvenile dermatomyositis	0.029	0.971
M24.81 Other specific joint derangements, not elsewhere classified (Shoulder region)	0.029	0.971
M23.42 Loose body in knee-Pst lig/hrn men	0.029	0.971
M32.9 Systemic lupus erythematosus, unspecified	0.029	0.971
M25.34 Other instability of joint (Hand)	0.029	0.971
M23.81 Other internal derangements of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.029	0.971
M48 Other spondylopathies	0.029	0.971
M23.47 Loose body in knee-Capsular lig	0.029	0.971
M23.45 Loose body in knee-Pst hrn lat men	0.029	0.971
M68 Disorders of synovium and tendon in diseases classified elsewhere	0.029	0.971
M24.82 Other specific joint derangements, not elsewhere classified (Upper arm)	0.029	0.971
M25.39 Other instability of joint (Site unspecified)	0.028	0.971
M25.38 Other instability of joint (Other)	0.028	0.971
M25.35 Other instability of joint (Pelvic region and thigh)	0.028	0.971
M25.32 Other instability of joint (Upper arm)	0.028	0.971
M25.30 Other instability of joint (Multiple sites)	0.028	0.971
M35.4 Diffuse (eosinophilic) fasciitis	0.028	0.971
M62.8 Other specified disorders of muscle	0.028	0.971
M23.09 Cystic meniscus (Unspecified ligament or Unspecified meniscus)	0.028	0.971
M24.27 Disorder of ligament (Ankle and foot)	0.028	0.972
M23.04 Cystic meniscus (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.028	0.972
M24.17 Other articular cartilage disorders (Ankle and foot)	0.028	0.972
M33.2 Polymyositis	0.028	0.972
M35.9 Systemic involvement of connective tissue, unspecified	0.028	0.972
M35.6 Relapsing panniculitis [Weber-Christian]	0.028	0.972
M35.5 Multifocal fibrosclerosis	0.028	0.972
M23.80 Other internal derangements of knee (Multiple sites)	0.028	0.972
M24.28 Disorder of ligament (Other)	0.028	0.972
M25.33 Other instability of joint (Forearm)	0.028	0.972
M24.11 Other articular cartilage disorders (Shoulder region)	0.028	0.972
M24.89 Other specific joint derangements, not elsewhere classified (Site unspecified)	0.028	0.972
M24.80 Other specific joint derangements, not elsewhere classified (Multiple sites)	0.028	0.972
M32.1 Systemic lupus erythematosus with organ or system involvement	0.028	0.972
M23.40 Loose body in knee-Mult sites	0.028	0.972
M47.99 Spondylosis, unspecified (Site unspecified)	0.028	0.972
M47.1 Other spondylosis with myelopathy	0.028	0.972
M53.38 Sacrococcygeal disorders, not elsewhere classified-Sacral/s	0.028	0.972
M40 Kyphosis and lordosis	0.028	0.972
M35.8 Other specified systemic involvement of connective tissue	0.028	0.972
M23.02 Cystic meniscus (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.028	0.972
M24.87 Other specific joint derangements, not elsewhere classified (Ankle and foot)	0.028	0.972
M25.64 Stiffness of joint, not elsewhere classified (Hand)	0.028	0.972
M24.83 Other specific joint derangements, not elsewhere classified (Forearm)	0.028	0.972
M24.25 Disorder of ligament (Pelvic region and thigh)	0.028	0.972
M36.4 Arthropathy in hypersensitivity reactions classified elsewhere	0.028	0.972
M36.3 Arthropathy in other blood disorders	0.028	0.972
M36.2 Haemophilic arthropathy	0.028	0.972
M36.1 Arthropathy in neoplastic disease	0.028	0.972
M36.0 Dermato(poly)myositis in neoplastic disease	0.028	0.972
M23.84 Other internal derangements of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.028	0.972
M77 Other enthesopathies	0.028	0.972
M23.87 Other internal derangements of knee (Capsular ligament)	0.028	0.972
M23.07 Cystic meniscus-Capsular lig	0.027	0.972
M23.05 Cystic meniscus (Posterior horn of lateral meniscus)	0.027	0.972
M23.01 Cystic meniscus (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.027	0.972
M23.00 Cystic meniscus (Multiple sites)	0.027	0.972
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)	0.028	0.972
M23.29 Derangement of meniscus due to old tear or injury (Unspecified ligament or Unspecified meniscus)	0.027	0.972
M25.31 Other instability of joint (Shoulder region)	0.027	0.972
M24.29 Disorder of ligament (Site unspecified)	0.027	0.972
M24.22 Disorder of ligament (Upper arm)	0.027	0.972
M24.20 Disorder of ligament (Multiple sites)	0.027	0.972
M23.23 Derangement of meniscus due to old tear or injury (Medial collateral ligament or Other and unspecified medial meniscus)	0.028	0.972
M15-M19 Arthrosis	0.028	0.972
M84 Disorders of continuity of bone	0.027	0.972
M23.82 Other internal derangements of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.027	0.972
M23.83 Other internal derangements of knee (Medial collateral ligament or Other and unspecified medial meniscus)	0.027	0.972
M24.21 Disorder of ligament (Shoulder region)	0.027	0.972
M23.86 Other internal derangements of knee (Other and unspecified lateral meniscus)	0.027	0.973
M05.8 Other seropositive rheumatoid arthritis	0.027	0.973
M92.6 Juvenile osteochondrosis of tarsus	0.027	0.973
M23.85 Other internal derangements of knee (Posterior horn of lateral meniscus)	0.027	0.973
M96 Postprocedural musculoskeletal disorders, not elsewhere classified	0.027	0.973
M25.09 Haemarthrosis (Site unspecified)	0.027	0.973
M25.08 Haemarthrosis (Other)	0.027	0.973
M25.07 Haemarthrosis (Ankle and foot)	0.027	0.973
M25.05 Haemarthrosis (Pelvic region and thigh)	0.027	0.973
M25.04 Haemarthrosis (Hand)	0.027	0.973
M25.03 Haemarthrosis (Forearm)	0.027	0.973
M25.02 Haemarthrosis (Upper arm)	0.027	0.973
M25.01 Haemarthrosis (Shoulder region)	0.027	0.973
M25.00 Haemarthrosis (Multiple sites)	0.027	0.973
M71 Other bursopathies	0.027	0.973
M07.5 Arthropathy in ulcerative colitis	0.027	0.973
M07.4 Arthropathy in Crohn's disease [regional enteritis]	0.027	0.973
M07.2 Psoriatic spondylitis	0.027	0.973
M07.1 Arthritis mutilans	0.027	0.973
M07.0 Distal interphalangeal psoriatic arthropathy	0.027	0.973
M23.03 Cystic meniscus (Medial collateral ligament or Other and unspecified medial meniscus)	0.027	0.973
M25.74 Osteophyte (Hand)	0.027	0.973
M24.51 Contracture of joint (Shoulder region)	0.027	0.973
M05.3 Rheumatoid arthritis with involvement of other organs and systems	0.027	0.973
M92.7 Juvenile osteochondrosis of metatarsus	0.027	0.973
M45.X9 Ankylosing spondylitis (Site unspecified)	0.027	0.973
M13.00 Polyarthritis, unspecified (Multiple sites)	0.027	0.973
M41 Scoliosis	0.027	0.973
M62.1 Other rupture of muscle (nontraumatic)	0.027	0.973
M24.47 Recurrent dislocation and subluxation of joint (Ankle and foot)	0.026	0.973
M62.5 Muscle wasting and atrophy, not elsewhere classified	0.026	0.973
M07.6 Other enteropathic arthropathies	0.026	0.973
M53.39 Sacrococcygeal disorders, not elsewhere classified-Site uns	0.026	0.973
M24.66 Ankylosis of joint (Lower leg)	0.026	0.973
M23.61 Other spontaneous disruption of ligament(s) of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.026	0.973
M05.1 Rheumatoid lung disease	0.026	0.973
M70 Soft tissue disorders related to use, overuse and pressure	0.026	0.973
M24.57 Contracture of joint (Ankle and foot)	0.026	0.974
M86-M90 Other osteopathies	0.026	0.974
M62.9 Disorder of muscle, unspecified	0.026	0.974
M24.88 Other specific joint derangements, not elsewhere classified (Other)	0.026	0.974
M42 Spinal osteochondrosis	0.026	0.974
M67 Other disorders of synovium and tendon	0.026	0.974
M94.9 Disorder of cartilage, unspecified	0.026	0.974
M35.7 Hypermobility syndrome	0.026	0.974
M24.55 Contracture of joint (Pelvic region and thigh)	0.026	0.974
M66 Spontaneous rupture of synovium and tendon	0.026	0.974
M23.16 Discoid meniscus (congenital) (Other and unspecified lateral meniscus)	0.026	0.974
M25.37 Other instability of joint (Ankle and foot)	0.026	0.974
M05.0 Felty's syndrome	0.026	0.974
M94.2 Chondromalacia	0.026	0.974
M62.0 Diastasis of muscle	0.026	0.974
M47.0 Anterior spinal and vertebral artery compression syndromes	0.026	0.974
M24.65 Ankylosis of joint (Pelvic region and thigh)	0.026	0.974
M47.90 Spondylosis, unspecified (Multiple sites in spine)	0.026	0.974
M36.8 Systemic disorders of connective tissue in other diseases classified elsewhere	0.026	0.974
M23.69 Other spontaneous disruption of ligament(s) of knee (Unspecified ligament or Unspecified meniscus)	0.026	0.974
M23.67 Other spontaneous disruption of ligament(s) of knee (Capsular ligament)	0.026	0.974
M23.66 Other spontaneous disruption of ligament(s) of knee-O/unsp	0.026	0.974
M23.65 Other spontaneous disruption of ligament(s) of knee-Pst hrn	0.026	0.974
M23.64 Other spontaneous disruption of ligament(s) of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.026	0.974
M23.63 Other spontaneous disruption of ligament(s) of knee (Medial collateral ligament or Other and unspecified medial meniscus)	0.026	0.974
M23.62 Other spontaneous disruption of ligament(s) of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.026	0.974
M23.60 Other spontaneous disruption of ligament(s) of knee (Multiple sites)	0.026	0.974
M24.52 Contracture of joint (Upper arm)	0.026	0.974
M24.96 Joint derangement, unspecified (Lower leg)	0.026	0.974
M62.4 Contracture of muscle	0.026	0.974
M24.91 Joint derangement, unspecified (Shoulder region)	0.026	0.974
M23.19 Discoid meniscus (congenital) (Unspecified ligament or Unspecified meniscus)	0.026	0.974
M23.17 Discoid meniscus (congenital)-Capsular lig	0.026	0.974
M23.15 Discoid meniscus (congenital) (Posterior horn of lateral meniscus)	0.026	0.974
M23.14 Discoid meniscus (congenital) (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.026	0.974
M23.13 Discoid meniscus (congenital) (Medial collateral ligament or Other and unspecified medial meniscus)	0.026	0.974
M23.12 Discoid meniscus (congenital) (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.026	0.974
M23.11 Discoid meniscus (congenital) (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.026	0.974
M23.10 Discoid meniscus (congenital) (Multiple sites)	0.026	0.974
M24.94 Joint derangement, unspecified (Hand)	0.026	0.974
M53.37 Sacrococcygeal disorders, not elsewhere classified-Lumbosac	0.026	0.974
M53.36 Sacrococcygeal disorders, not elsewhere classified-Lumbar	0.026	0.974
M53.35 Sacrococcygeal disorders, not elsewhere classified-Thoracol	0.026	0.974
M53.34 Sacrococcygeal disorders, not elsewhere classified-Thoracic	0.026	0.974
M53.33 Sacrococcygeal disorders, not elsewhere classified-Cervicot	0.026	0.974
M53.32 Sacrococcygeal disorders, not elsewhere classified-Cervical	0.026	0.974
M53.31 Sacrococcygeal disorders, not elsewhere classified-Occipit-	0.026	0.974
M53.30 Sacrococcygeal disorders, not elsewhere classified-Mult sit	0.026	0.974
M94.3 Chondrolysis	0.026	0.974
M94.1 Relapsing polychondritis	0.026	0.974
M92.2 Juvenile osteochondrosis of hand	0.026	0.974

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations