TreeWAS – Variant ID: rs28848172

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E03.9 Hypothyroidism, unspecified	0.000	0.000	1.000
J45.9 Asthma, unspecified	0.000	0.003	0.997
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.914	0.048	0.038
M20-M25 Other joint disorders	0.905	0.093	0.001
M70-M79 Other soft tissue disorders	0.885	0.108	0.007
E03 Other hypothyroidism	0.000	0.117	0.882
M23 Internal derangement of knee	0.877	0.123	0.000
M79 Other soft tissue disorders, not elsewhere classified	0.871	0.128	0.001
M50-M54 Other dorsopathies	0.858	0.133	0.009
M79.6 Pain in limb	0.862	0.137	0.000
M05-M14 Inflammatory polyarthropathies	0.756	0.140	0.104
M65-M68 Disorders of synovium and tendon	0.844	0.142	0.014
M79.66 Pain in limb (Lower leg)	0.853	0.147	0.000
M15-M19 Arthrosis	0.833	0.166	0.002
J45 Asthma	0.005	0.174	0.821
M54 Dorsalgia	0.820	0.179	0.002
M86-M90 Other osteopathies	0.802	0.180	0.019
E00-E07 Disorders of thyroid gland	0.001	0.180	0.819
M24 Other specific joint derangements	0.814	0.186	0.000
M20 Acquired deformities of fingers and toes	0.804	0.196	0.000
M54.9 Dorsalgia, unspecified	0.800	0.200	0.000
M06.9 Rheumatoid arthritis, unspecified	0.003	0.201	0.797
M25 Other joint disorders, not elsewhere classified	0.799	0.201	0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.000	0.205	0.795
M23.3 Other meniscus derangements	0.795	0.205	0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.000	0.209	0.791
M79.67 Pain in limb (Ankle and foot)	0.790	0.210	0.000
M23.8 Other internal derangements of knee	0.787	0.213	0.000
M13 Other arthritis	0.738	0.217	0.045
M80-M85 Disorders of bone density and structure	0.750	0.218	0.031
M20.2 Hallux rigidus	0.767	0.233	0.000
M65 Synovitis and tenosynovitis	0.762	0.233	0.005
M17 Gonarthrosis [arthrosis of knee]	0.753	0.247	0.000
M17.1 Other primary gonarthrosis	0.742	0.258	0.000
M18 Arthrosis of first carpometacarpal joint	0.736	0.263	0.001
M54.99 Dorsalgia, unspecified (Site unspecified)	0.735	0.265	0.000
M13.9 Arthritis, unspecified	0.726	0.271	0.002
M06 Other rheumatoid arthritis	0.173	0.277	0.550
M23.36 Other meniscus derangements (Other and unspecified lateral meniscus)	0.723	0.277	0.000
# Top node	0.127	0.279	0.594
M79.7 Fibromyalgia	0.720	0.279	0.000
E05 Thyrotoxicosis [hyperthyroidism]	0.000	0.279	0.720
J40-J47 Chronic lower respiratory diseases	0.015	0.285	0.700
M89 Other disorders of bone	0.704	0.286	0.010
M23.81 Other internal derangements of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.714	0.286	0.000
M60-M63 Disorders of muscles	0.682	0.292	0.026
M13.90 Arthritis, unspecified (Multiple sites)	0.706	0.294	0.000
M00-M03 Infectious arthropathies	0.679	0.295	0.026
M20.5 Other deformities of toe(s) (acquired)	0.700	0.300	0.000
M21 Other acquired deformities of limbs	0.699	0.300	0.001
M25.6 Stiffness of joint, not elsewhere classified	0.695	0.305	0.000
M67 Other disorders of synovium and tendon	0.687	0.306	0.007
M65.9 Synovitis and tenosynovitis, unspecified	0.691	0.307	0.001
M54.94 Dorsalgia, unspecified (Thoracic region)	0.690	0.310	0.000
M13.99 Arthritis, unspecified (Site unspecified)	0.690	0.310	0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.661	0.314	0.024
M51 Other intervertebral disk disorders	0.681	0.316	0.004
M79.62 Pain in limb (Upper arm)	0.684	0.316	0.000
M84 Disorders of continuity of bone	0.664	0.322	0.015
K90.0 Coeliac disease	0.000	0.323	0.677
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.001	0.324	0.675
M79.2 Neuralgia and neuritis, unspecified	0.672	0.327	0.001
Chapter X Diseases of the respiratory system	0.040	0.327	0.633
M24.2 Disorder of ligament	0.669	0.331	0.000
M23.2 Derangement of meniscus due to old tear or injury	0.669	0.331	0.000
M91-M94 Chondropathies	0.641	0.332	0.027
M40-M43 Deforming dorsopathies	0.645	0.332	0.023
M70 Soft tissue disorders related to use, overuse and pressure	0.662	0.334	0.004
M23.39 Other meniscus derangements (Unspecified ligament or Unspecified meniscus)	0.666	0.334	0.000
M54.4 Lumbago with sciatica	0.665	0.334	0.001
M18.0 Primary arthrosis of first carpometacarpal joints, bilateral	0.663	0.337	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.010	0.338	0.652
M79.64 Pain in limb (Hand)	0.662	0.338	0.000
M79.5 Residual foreign body in soft tissue	0.661	0.338	0.001
M23.4 Loose body in knee	0.661	0.339	0.000
M25.7 Osteophyte	0.660	0.340	0.000
J44 Other chronic obstructive pulmonary disease	0.001	0.341	0.658
M06.94 Rheumatoid arthritis, unspecified (Hand)	0.001	0.343	0.655
E06 Thyroiditis	0.001	0.344	0.656
M15 Polyarthrosis	0.655	0.344	0.001
M23.5 Chronic instability of knee	0.650	0.350	0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.649	0.350	0.001
M33 Dermatopolymyositis	0.649	0.350	0.001
M32 Systemic lupus erythematosus	0.649	0.350	0.001
M30 Polyarteritis nodosa and related conditions	0.649	0.350	0.001
M24.5 Contracture of joint	0.645	0.355	0.000
M79.69 Pain in limb (Site unspecified)	0.640	0.360	0.000
M23.33 Other meniscus derangements (Medial collateral ligament or Other and unspecified medial meniscus)	0.640	0.360	0.000
M25.9 Joint disorder, unspecified	0.640	0.360	0.000
M76 Enthesopathies of lower limb, excluding foot	0.635	0.360	0.005
M73 Soft tissue disorders in diseases classified elsewhere	0.635	0.360	0.005
M72 Fibroblastic disorders	0.634	0.362	0.004
M54.96 Dorsalgia, unspecified (Lumbar region)	0.634	0.365	0.000
M23.89 Other internal derangements of knee (Unspecified ligament or Unspecified meniscus)	0.634	0.366	0.000
E03.5 Myxoedema coma	0.000	0.367	0.632
E03.4 Atrophy of thyroid (acquired)	0.000	0.367	0.632
E03.3 Postinfectious hypothyroidism	0.000	0.367	0.632
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.000	0.367	0.632
E03.1 Congenital hypothyroidism without goitre	0.000	0.367	0.632
E03.0 Congenital hypothyroidism with diffuse goitre	0.000	0.367	0.632
M24.1 Other articular cartilage disorders	0.631	0.368	0.000
M54.3 Sciatica	0.629	0.369	0.001
M23.9 Internal derangement of knee, unspecified	0.629	0.371	0.000
M23.6 Other spontaneous disruption of ligament(s) of knee	0.629	0.371	0.000
M23.1 Discoid meniscus (congenital)	0.629	0.371	0.000
M23.0 Cystic meniscus	0.629	0.371	0.000
M66 Spontaneous rupture of synovium and tendon	0.619	0.372	0.010
E07 Other disorders of thyroid	0.001	0.372	0.627
E05.9 Thyrotoxicosis, unspecified	0.000	0.373	0.627
M79.9 Soft tissue disorder, unspecified	0.625	0.375	0.001
M79.4 Hypertrophy of (infrapatellar) fat pad	0.625	0.375	0.001
M79.3 Panniculitis, unspecified	0.625	0.375	0.001
M54.97 Dorsalgia, unspecified (Lumbosacral region)	0.622	0.378	0.000
M34 Systemic sclerosis	0.620	0.379	0.001
M87 Osteonecrosis	0.609	0.379	0.012
M71 Other bursopathies	0.616	0.379	0.005
M24.8 Other specific joint derangements, not elsewhere classified	0.618	0.381	0.000
M79.68 Pain in limb (Other)	0.618	0.381	0.000
M79.61 Pain in limb (Shoulder region)	0.618	0.381	0.000
M54.1 Radiculopathy	0.617	0.382	0.001
M14 Arthropathies in other diseases classified elsewhere	0.542	0.383	0.075
M12 Other specific arthropathies	0.542	0.383	0.075
M09 Juvenile arthritis in diseases classified elsewhere	0.542	0.383	0.075
M08 Juvenile arthritis	0.542	0.383	0.075
M54.90 Dorsalgia, unspecified (Multiple sites in spine)	0.615	0.384	0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere	0.605	0.385	0.010
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)	0.002	0.385	0.613
M65.97 Synovitis and tenosynovitis, unspecified (Ankle and foot)	0.613	0.386	0.001
J46 Status asthmaticus	0.007	0.387	0.606
K90 Intestinal malabsorption	0.000	0.388	0.612
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.011	0.388	0.601
J00-J06 Acute upper respiratory infections	0.011	0.390	0.599
M53 Other dorsopathies, not elsewhere classified	0.598	0.395	0.007
D60-D64 Aplastic and other anaemias	0.005	0.396	0.599
D64.9 Anaemia, unspecified	0.000	0.396	0.604
D64 Other anaemias	0.002	0.398	0.600
M89.8 Other specified disorders of bone	0.595	0.400	0.006
M79.79 Fibromyalgia (Site unspecified)	0.598	0.402	0.000
M88 Paget's disease of bone [osteitis deformans]	0.585	0.402	0.013
M24.4 Recurrent dislocation and subluxation of joint	0.597	0.402	0.000
M25.77 Osteophyte (Ankle and foot)	0.597	0.403	0.000
C44.3 Skin of other and unspecified parts of face	0.000	0.403	0.597
M25.8 Other specified joint disorders	0.596	0.404	0.000
M13.97 Arthritis, unspecified (Ankle and foot)	0.595	0.404	0.001
C44 Other malignant neoplasms of skin	0.000	0.404	0.596
M23.21 Derangement of meniscus due to old tear or injury (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.595	0.405	0.000
M51.2 Other specified intervertebral disk displacement	0.593	0.406	0.000
J45.8 Mixed asthma	0.004	0.408	0.588
J45.1 Nonallergic asthma	0.004	0.408	0.588
J44.8 Other specified chronic obstructive pulmonary disease	0.000	0.408	0.592
M77 Other enthesopathies	0.586	0.409	0.005
M24.0 Loose body in joint	0.590	0.409	0.000
M79.1 Myalgia	0.590	0.410	0.001
M54.8 Other dorsalgia	0.588	0.411	0.001
M54.0 Panniculitis affecting regions of neck and back	0.588	0.411	0.001
M11 Other crystal arthropathies	0.514	0.411	0.075
M90 Osteopathies in diseases classified elsewhere	0.575	0.412	0.014
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.001	0.412	0.587
E00 Congenital iodine-deficiency syndrome	0.001	0.412	0.587
E02 Subclinical iodine-deficiency hypothyroidism	0.001	0.412	0.587
C43-C44 Melanoma and other malignant neoplasms of skin	0.000	0.415	0.585
M79.63 Pain in limb (Forearm)	0.585	0.415	0.000
M07 Psoriatic and enteropathic arthropathies	0.512	0.415	0.073
M20.6 Acquired deformity of toe(s), unspecified	0.585	0.415	0.000
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)	0.585	0.415	0.000
Chapter II Neoplasms	0.000	0.415	0.584
M86 Osteomyelitis	0.571	0.416	0.013
M24.9 Joint derangement, unspecified	0.584	0.416	0.000
M24.7 Protrusio acetabuli	0.584	0.416	0.000
M24.6 Ankylosis of joint	0.584	0.416	0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.584	0.416	0.000
M65.3 Trigger finger	0.581	0.416	0.003
M89.0 Algoneurodystrophy	0.576	0.418	0.006
K90-K93 Other diseases of the digestive system	0.000	0.418	0.582
M18.1 Other primary arthrosis of first carpometacarpal joint	0.580	0.420	0.000
M54.36 Sciatica (Lumbar region)	0.580	0.420	0.000
M23.31 Other meniscus derangements (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.579	0.421	0.000
M65.96 Synovitis and tenosynovitis, unspecified (Lower leg)	0.577	0.423	0.001
J45.0 Predominantly allergic asthma	0.003	0.423	0.574
M79.0 Rheumatism, unspecified	0.575	0.425	0.001
J20-J22 Other acute lower respiratory infections	0.017	0.425	0.558
M54.98 Dorsalgia, unspecified (Sacral and sacrococcygeal region)	0.573	0.426	0.000
M54.95 Dorsalgia, unspecified (Thoracolumbar region)	0.573	0.426	0.000
M54.93 Dorsalgia, unspecified (Cervicothoracic region)	0.573	0.426	0.000
M54.92 Dorsalgia, unspecified (Cervical region)	0.573	0.426	0.000
M54.91 Dorsalgia, unspecified (Occipito-atlanto-axial region)	0.573	0.426	0.000
M06.98 Rheumatoid arthritis, unspecified (Other)	0.002	0.427	0.571
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.002	0.427	0.571
M06.92 Rheumatoid arthritis, unspecified (Upper arm)	0.002	0.427	0.571
M25.3 Other instability of joint	0.572	0.427	0.000
M25.2 Flail joint	0.572	0.427	0.000
M25.1 Fistula of joint	0.572	0.427	0.000
M25.0 Haemarthrosis	0.572	0.427	0.000
J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection	0.000	0.429	0.571
M21.0 Valgus deformity, not elsewhere classified	0.570	0.429	0.001
M75 Shoulder lesions	0.568	0.430	0.002
M23.37 Other meniscus derangements-Capsular lig	0.570	0.430	0.000
M23.35 Other meniscus derangements (Posterior horn of lateral meniscus)	0.570	0.430	0.000
M23.34 Other meniscus derangements (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.570	0.430	0.000
M21.4 Flat foot [pes planus] (acquired)	0.568	0.431	0.001
M25.4 Effusion of joint	0.568	0.431	0.000
M85 Other disorders of bone density and structure	0.547	0.432	0.021
J02 Acute pharyngitis	0.005	0.433	0.562
M84.1 Nonunion of fracture [pseudarthrosis]	0.560	0.433	0.007
Chapter XI Diseases of the digestive system	0.001	0.433	0.565
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.002	0.435	0.563
M23.87 Other internal derangements of knee (Capsular ligament)	0.564	0.435	0.000
M23.86 Other internal derangements of knee (Other and unspecified lateral meniscus)	0.564	0.435	0.000
M23.85 Other internal derangements of knee (Posterior horn of lateral meniscus)	0.564	0.435	0.000
M23.84 Other internal derangements of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.564	0.435	0.000
M23.82 Other internal derangements of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.564	0.435	0.000
M23.80 Other internal derangements of knee (Multiple sites)	0.564	0.435	0.000
E05.0 Thyrotoxicosis with diffuse goitre	0.000	0.435	0.564
M80 Osteoporosis with pathological fracture	0.544	0.436	0.019
E04 Other non-toxic goitre	0.000	0.437	0.563
M13.8 Other specified arthritis	0.529	0.438	0.032
M13.1 Monoarthritis, not elsewhere classified	0.529	0.438	0.032
M13.0 Polyarthritis, unspecified	0.529	0.438	0.032
C44.7 Skin of lower limb, including hip	0.000	0.439	0.561
M83 Adult osteomalacia	0.538	0.439	0.023
M82 Osteoporosis in diseases classified elsewhere	0.538	0.439	0.023
M84.0 Malunion of fracture	0.551	0.441	0.009
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)	0.558	0.442	0.000
M06.0 Seronegative rheumatoid arthritis	0.091	0.442	0.467
M65.4 Radial styloid tenosynovitis [de Quervain]	0.549	0.448	0.003
M67.8 Other specified disorders of synovium and tendon	0.549	0.448	0.003
E20-E35 Disorders of other endocrine glands	0.005	0.450	0.546
M65.8 Other synovitis and tenosynovitis	0.546	0.450	0.004
M65.2 Calcific tendinitis	0.546	0.450	0.004
M65.1 Other infective (teno)synovitis	0.546	0.450	0.004
M65.0 Abscess of tendon sheath	0.546	0.450	0.004
Chapter XII Diseases of the skin and subcutaneous tissue	0.007	0.451	0.542
E03.8 Other specified hypothyroidism	0.001	0.453	0.547
M75.1 Rotator cuff syndrome	0.546	0.454	0.000
M54.6 Pain in thoracic spine	0.543	0.455	0.001
M05 Seropositive rheumatoid arthritis	0.461	0.456	0.083
J44.9 Chronic obstructive pulmonary disease, unspecified	0.000	0.459	0.541
M13.93 Arthritis, unspecified (Forearm)	0.539	0.459	0.002
M79.70 Fibromyalgia (Multiple sites)	0.540	0.460	0.000
M17.5 Other secondary gonarthrosis	0.540	0.460	0.000
M17.4 Other secondary gonarthrosis, bilateral	0.540	0.460	0.000
M17.2 Posttraumatic gonarthrosis, bilateral	0.540	0.460	0.000
E06.3 Autoimmune thyroiditis	0.000	0.461	0.539
M24.24 Disorder of ligament (Hand)	0.539	0.461	0.000
M65.91 Synovitis and tenosynovitis, unspecified (Shoulder region)	0.537	0.462	0.001
J02.9 Acute pharyngitis, unspecified	0.001	0.463	0.536
M67.1 Other contracture of tendon (sheath)	0.530	0.466	0.004
M62 Other disorders of muscle	0.516	0.466	0.018
M23.25 Derangement of meniscus due to old tear or injury (Posterior horn of lateral meniscus)	0.533	0.467	0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)	0.002	0.467	0.530
M65.95 Synovitis and tenosynovitis, unspecified (Pelvic region and thigh)	0.531	0.468	0.001
M72.2 Plantar fascial fibromatosis	0.528	0.470	0.003
M50 Cervical disk disorders	0.524	0.470	0.006
M54.46 Lumbago with sciatica (Lumbar region)	0.529	0.471	0.001
M15.1 Heberden's nodes (with arthropathy)	0.528	0.471	0.001
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.006	0.471	0.522
M18.5 Other secondary arthrosis of first carpometacarpal joint	0.528	0.472	0.001
M18.4 Other secondary arthrosis of first carpometacarpal joints, bilateral	0.528	0.472	0.001
M18.3 Other posttraumatic arthrosis of first carpometacarpal joint	0.528	0.472	0.001
M18.2 Posttraumatic arthrosis of first carpometacarpal joints, bilateral	0.528	0.472	0.001
M00 Pyogenic arthritis	0.510	0.472	0.018
M31 Other necrotising vasculopathies	0.526	0.473	0.001
M25.96 Joint disorder, unspecified (Lower leg)	0.526	0.474	0.000
M24.54 Contracture of joint (Hand)	0.523	0.476	0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue	0.000	0.477	0.523
M13.92 Arthritis, unspecified (Upper arm)	0.521	0.477	0.002
M79.29 Neuralgia and neuritis, unspecified (Site unspecified)	0.521	0.479	0.000
K20-K31 Diseases of oesophagus, stomach and duodenum	0.000	0.480	0.520
M13.98 Arthritis, unspecified (Other)	0.518	0.481	0.002
M89.87 Other specified disorders of bone (Ankle and foot)	0.516	0.481	0.003
M06.8 Other specified rheumatoid arthritis	0.124	0.481	0.394
M06.4 Inflammatory polyarthropathy	0.124	0.481	0.394
M06.3 Rheumatoid nodule	0.124	0.481	0.394
M06.2 Rheumatoid bursitis	0.124	0.481	0.394
M06.1 Adult-onset Still's disease	0.124	0.481	0.394
M13.95 Arthritis, unspecified (Pelvic region and thigh)	0.517	0.482	0.002
M24.26 Disorder of ligament (Lower leg)	0.517	0.482	0.000
Chapter XVI Certain conditions originating in the perinatal period	0.091	0.483	0.426
M79.78 Fibromyalgia (Other)	0.517	0.483	0.000
M79.77 Fibromyalgia (Ankle and foot)	0.517	0.483	0.000
M79.76 Fibromyalgia (Lower leg)	0.517	0.483	0.000
M79.75 Fibromyalgia (Pelvic region and thigh)	0.517	0.483	0.000
M79.74 Fibromyalgia (Hand)	0.517	0.483	0.000
M79.73 Fibromyalgia (Forearm)	0.517	0.483	0.000
M79.72 Fibromyalgia (Upper arm)	0.517	0.483	0.000
M79.71 Fibromyalgia (Shoulder region)	0.517	0.483	0.000
E05.8 Other thyrotoxicosis	0.000	0.483	0.516
E05.5 Thyroid crisis or storm	0.000	0.483	0.516
E05.4 Thyrotoxicosis factitia	0.000	0.483	0.516
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.000	0.483	0.516
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.000	0.483	0.516
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.000	0.483	0.516
E50-E64 Other nutritional deficiencies	0.006	0.484	0.510
M23.26 Derangement of meniscus due to old tear or injury (Other and unspecified lateral meniscus)	0.515	0.485	0.000
J41 Simple and mucopurulent chronic bronchitis	0.011	0.487	0.502
M89.9 Disorder of bone, unspecified	0.506	0.487	0.006
M70.2 Olecranon bursitis	0.509	0.488	0.003
M54.49 Lumbago with sciatica (Site unspecified)	0.511	0.488	0.001
M89.6 Osteopathy after poliomyelitis	0.505	0.488	0.007
M89.5 Osteolysis	0.505	0.488	0.007
M89.4 Other hypertrophic osteo-arthropathy	0.505	0.488	0.007
M89.3 Hypertrophy of bone	0.505	0.488	0.007
M89.2 Other disorders of bone development and growth	0.505	0.488	0.007
M89.1 Epiphyseal arrest	0.505	0.488	0.007
M79.54 Residual foreign body in soft tissue (Hand)	0.511	0.489	0.000
J22 Unspecified acute lower respiratory infection	0.000	0.490	0.509
C44.0 Skin of lip	0.000	0.491	0.509
M23.29 Derangement of meniscus due to old tear or injury (Unspecified ligament or Unspecified meniscus)	0.509	0.491	0.000
M63 Disorders of muscle in diseases classified elsewhere	0.489	0.492	0.019
M61 Calcification and ossification of muscle	0.489	0.492	0.019
M60 Myositis	0.489	0.492	0.019
E10-E14 Diabetes mellitus	0.002	0.493	0.505
M95 Other acquired deformities of musculoskeletal system and connective tissue	0.491	0.493	0.016
M23.30 Other meniscus derangements (Multiple sites)	0.507	0.493	0.000
K20 Oesophagitis	0.000	0.494	0.506
M23.49 Loose body in knee-Unspec lig/men	0.506	0.494	0.000
M25.61 Stiffness of joint, not elsewhere classified (Shoulder region)	0.506	0.494	0.000
M03 Postinfective and reactive arthropathies in diseases classified elsewhere	0.487	0.494	0.019
M02 Reactive arthropathies	0.487	0.494	0.019
M01 Direct infections of joint in infectious and parasitic diseases classified elsewhere	0.487	0.494	0.019
M23.83 Other internal derangements of knee (Medial collateral ligament or Other and unspecified medial meniscus)	0.504	0.496	0.000
M24.11 Other articular cartilage disorders (Shoulder region)	0.502	0.498	0.000
M21.9 Acquired deformity of limb, unspecified	0.501	0.498	0.001
M21.8 Other specified acquired deformities of limbs	0.501	0.498	0.001
M21.7 Unequal limb length (acquired)	0.501	0.498	0.001
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot	0.501	0.498	0.001
M21.2 Flexion deformity	0.501	0.498	0.001
M54.2 Cervicalgia	0.500	0.499	0.001
J03 Acute tonsillitis	0.006	0.499	0.495
M54.18 Radiculopathy (Sacral and sacrococcygeal region)	0.500	0.499	0.001
Chapter XXII Codes for special purposes	0.084	0.500	0.416
D00-D09 In situ neoplasms	0.000	0.501	0.499
M25.69 Stiffness of joint, not elsewhere classified (Site unspecified)	0.498	0.501	0.000
M25.68 Stiffness of joint, not elsewhere classified (Other)	0.498	0.501	0.000
M25.65 Stiffness of joint, not elsewhere classified (Pelvic region and thigh)	0.498	0.501	0.000
M25.64 Stiffness of joint, not elsewhere classified (Hand)	0.498	0.501	0.000
M25.63 Stiffness of joint, not elsewhere classified (Forearm)	0.498	0.501	0.000
M25.62 Stiffness of joint, not elsewhere classified (Upper arm)	0.498	0.501	0.000
M25.60 Stiffness of joint, not elsewhere classified (Multiple sites)	0.498	0.501	0.000
M67.9 Disorder of synovium and tendon, unspecified	0.493	0.502	0.005
M67.4 Ganglion	0.493	0.502	0.005
M67.3 Transient synovitis	0.493	0.502	0.005
M67.2 Synovial hypertrophy, not elsewhere classified	0.493	0.502	0.005
M67.0 Short Achilles tendon (acquired)	0.493	0.502	0.005
M21.6 Other acquired deformities of ankle and foot	0.496	0.503	0.001
M65.99 Synovitis and tenosynovitis, unspecified (Site unspecified)	0.496	0.503	0.001
M65.98 Synovitis and tenosynovitis, unspecified (Other)	0.496	0.503	0.001
M65.92 Synovitis and tenosynovitis, unspecified (Upper arm)	0.496	0.503	0.001
M65.90 Synovitis and tenosynovitis, unspecified (Multiple sites)	0.496	0.503	0.001
M10 Gout	0.421	0.504	0.074
M94 Other disorders of cartilage	0.476	0.505	0.018
C73-C75 Malignant neoplasms of thyroid and other endocrine glands	0.000	0.505	0.494
M17.3 Other posttraumatic gonarthrosis	0.494	0.505	0.000
M20.0 Deformity of finger(s)	0.493	0.507	0.000
D37-D48 Neoplasms of uncertain or unknown behaviour	0.000	0.507	0.493
M70.4 Prepatellar bursitis	0.490	0.507	0.003
M79.28 Neuralgia and neuritis, unspecified (Other)	0.492	0.507	0.000
M24.15 Other articular cartilage disorders (Pelvic region and thigh)	0.492	0.507	0.000
M99 Biomechanical lesions, not elsewhere classified	0.474	0.508	0.018
M51.3 Other specified intervertebral disk degeneration	0.488	0.509	0.003
M51.1 Lumbar and other intervertebral disk disorders with radiculopathy	0.488	0.509	0.003
M51.4 Schmorl's nodes	0.488	0.509	0.003
M51.8 Other specified intervertebral disk disorders	0.488	0.509	0.003
M17.0 Primary gonarthrosis, bilateral	0.490	0.509	0.000
E07.9 Disorder of thyroid, unspecified	0.000	0.510	0.490
M23.24 Derangement of meniscus due to old tear or injury (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.490	0.510	0.000
M20.1 Hallux valgus (acquired)	0.489	0.511	0.000
L40-L45 Papulosquamous disorders	0.003	0.512	0.485
M89.04 Algoneurodystrophy (Hand)	0.485	0.512	0.003
M23.51 Chronic instability of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.487	0.512	0.000
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue	0.004	0.513	0.483
M84.9 Disorder of continuity of bone, unspecified	0.476	0.513	0.011
M84.8 Other disorders of continuity of bone	0.476	0.513	0.011
M84.4 Pathological fracture, not elsewhere classified	0.476	0.513	0.011
M84.3 Stress fracture, not elsewhere classified	0.476	0.513	0.011
M84.2 Delayed union of fracture	0.476	0.513	0.011
M84.11 Nonunion of fracture [pseudarthrosis] (Shoulder region)	0.481	0.515	0.003
Chapter I Certain infectious and parasitic diseases	0.009	0.516	0.476
M25.74 Osteophyte (Hand)	0.483	0.517	0.000
C82 Follicular [nodular] non-Hodgkin's lymphoma	0.000	0.517	0.482
M79.27 Neuralgia and neuritis, unspecified (Ankle and foot)	0.482	0.518	0.001
M79.26 Neuralgia and neuritis, unspecified (Lower leg)	0.482	0.518	0.001
M79.25 Neuralgia and neuritis, unspecified (Pelvic region and thigh)	0.482	0.518	0.001
M79.24 Neuralgia and neuritis, unspecified (Hand)	0.482	0.518	0.001
M79.23 Neuralgia and neuritis, unspecified (Forearm)	0.482	0.518	0.001
M79.22 Neuralgia and neuritis, unspecified (Upper arm)	0.482	0.518	0.001
M79.21 Neuralgia and neuritis, unspecified (Shoulder region)	0.482	0.518	0.001
M79.20 Neuralgia and neuritis, unspecified (Multiple sites)	0.482	0.518	0.001
M25.45 Effusion of joint (Pelvic region and thigh)	0.482	0.518	0.000
D70-D77 Other diseases of blood and blood-forming organs	0.004	0.519	0.477
M20.3 Other deformity of hallux (acquired)	0.480	0.519	0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.002	0.520	0.478
M87.9 Osteonecrosis, unspecified	0.472	0.520	0.008
M24.29 Disorder of ligament (Site unspecified)	0.479	0.520	0.000
M24.28 Disorder of ligament (Other)	0.479	0.520	0.000
M24.27 Disorder of ligament (Ankle and foot)	0.479	0.520	0.000
M24.25 Disorder of ligament (Pelvic region and thigh)	0.479	0.520	0.000
M24.23 Disorder of ligament (Forearm)	0.479	0.520	0.000
M24.22 Disorder of ligament (Upper arm)	0.479	0.520	0.000
M24.21 Disorder of ligament (Shoulder region)	0.479	0.520	0.000
M24.20 Disorder of ligament (Multiple sites)	0.479	0.520	0.000
M23.27 Derangement of meniscus due to old tear or injury-Capsular	0.479	0.521	0.000
M92 Other juvenile osteochondrosis	0.460	0.521	0.020
M91 Juvenile osteochondrosis of hip and pelvis	0.460	0.521	0.020
M42 Spinal osteochondrosis	0.462	0.521	0.017
M40 Kyphosis and lordosis	0.462	0.521	0.017
M25.72 Osteophyte (Upper arm)	0.479	0.521	0.000
M24.85 Other specific joint derangements, not elsewhere classified (Pelvic region and thigh)	0.478	0.521	0.000
M96 Postprocedural musculoskeletal disorders, not elsewhere classified	0.461	0.522	0.017
M70.9 Unspecified soft tissue disorder related to use, overuse and pressure	0.475	0.522	0.003
M70.8 Other soft tissue disorders related to use, overuse and pressure	0.475	0.522	0.003
M70.7 Other bursitis of hip	0.475	0.522	0.003
M70.5 Other bursitis of knee	0.475	0.522	0.003
M70.3 Other bursitis of elbow	0.475	0.522	0.003
M70.1 Bursitis of hand	0.475	0.522	0.003
M70.0 Chronic crepitant synovitis of hand and wrist	0.475	0.522	0.003
M54.48 Lumbago with sciatica (Sacral and sacrococcygeal region)	0.477	0.523	0.001
M54.47 Lumbago with sciatica (Lumbosacral region)	0.477	0.523	0.001
M54.45 Lumbago with sciatica (Thoracolumbar region)	0.477	0.523	0.001
M54.44 Lumbago with sciatica-Thoracic	0.477	0.523	0.001
M54.43 Lumbago with sciatica-Cervicothoracic	0.477	0.523	0.001
M54.42 Lumbago with sciatica-Cervical	0.477	0.523	0.001
M54.41 Lumbago with sciatica-Occipit-atl-axl	0.477	0.523	0.001
M54.40 Lumbago with sciatica (Multiple sites in spine)	0.477	0.523	0.001
D80-D89 Certain disorders involving the immune mechanism	0.007	0.523	0.471
M41 Scoliosis	0.462	0.523	0.015
M18.9 Arthrosis of first carpometacarpal joint, unspecified	0.476	0.523	0.000
D06 Carcinoma in situ of cervix uteri	0.000	0.523	0.476
M19 Other arthrosis	0.475	0.524	0.001
M54.17 Radiculopathy (Lumbosacral region)	0.475	0.525	0.001
M84.04 Malunion of fracture (Hand)	0.470	0.525	0.005
M21.47 Flat foot [pes planus] (acquired)-Ankle/foot	0.474	0.525	0.000
J95-J99 Other diseases of the respiratory system	0.021	0.525	0.454
M79.59 Residual foreign body in soft tissue (Site unspecified)	0.474	0.525	0.001
M79.58 Residual foreign body in soft tissue (Other)	0.474	0.525	0.001
M79.57 Residual foreign body in soft tissue (Ankle and foot)	0.474	0.525	0.001
M79.56 Residual foreign body in soft tissue (Lower leg)	0.474	0.525	0.001
M79.55 Residual foreign body in soft tissue (Pelvic region and thigh)	0.474	0.525	0.001
M79.53 Residual foreign body in soft tissue (Forearm)	0.474	0.525	0.001
M79.52 Residual foreign body in soft tissue (Upper arm)	0.474	0.525	0.001
M79.51 Residual foreign body in soft tissue (Shoulder region)	0.474	0.525	0.001
M79.50 Residual foreign body in soft tissue (Multiple sites)	0.474	0.525	0.001
D69 Purpura and other haemorrhagic conditions	0.003	0.525	0.472
M23.47 Loose body in knee-Capsular lig	0.474	0.526	0.000
M23.46 Loose body in knee-O/unsp lat men	0.474	0.526	0.000
M23.45 Loose body in knee-Pst hrn lat men	0.474	0.526	0.000
M23.44 Loose body in knee-Lat lig/ant men	0.474	0.526	0.000
M23.43 Loose body in knee-Med lig/oth men	0.474	0.526	0.000
M23.42 Loose body in knee-Pst lig/hrn men	0.474	0.526	0.000
M23.41 Loose body in knee-Ant lig/hrn men	0.474	0.526	0.000
M23.40 Loose body in knee-Mult sites	0.474	0.526	0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx	0.000	0.526	0.474
M22 Disorders of patella	0.472	0.527	0.001
M81 Osteoporosis without pathological fracture	0.442	0.527	0.031
M25.79 Osteophyte (Site unspecified)	0.473	0.527	0.000
M25.73 Osteophyte (Forearm)	0.473	0.527	0.000
M25.70 Osteophyte (Multiple sites)	0.473	0.527	0.000
M25.76 Osteophyte (Lower leg)	0.471	0.529	0.000
E06.9 Thyroiditis, unspecified	0.001	0.529	0.470
E06.5 Other chronic thyroiditis	0.001	0.529	0.470
E06.4 Drug-induced thyroiditis	0.001	0.529	0.470
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.001	0.529	0.470
E06.1 Subacute thyroiditis	0.001	0.529	0.470
E06.0 Acute thyroiditis	0.001	0.529	0.470
M15.9 Polyarthrosis, unspecified	0.470	0.529	0.001
M15.0 Primary generalised (osteo)arthrosis	0.470	0.529	0.001
M15.8 Other polyarthrosis	0.470	0.529	0.001
M15.4 Erosive (osteo)arthrosis	0.470	0.529	0.001
M15.3 Secondary multiple arthrosis	0.470	0.529	0.001
M15.2 Bouchard's nodes (with arthropathy)	0.470	0.529	0.001
M43 Other deforming dorsopathies	0.452	0.533	0.015
M23.59 Chronic instability of knee (Unspecified ligament or Unspecified meniscus)	0.466	0.534	0.000
M23.57 Chronic instability of knee (Capsular ligament)	0.466	0.534	0.000
M23.56 Chronic instability of knee (Other and unspecified lateral meniscus)	0.466	0.534	0.000
M23.55 Chronic instability of knee (Posterior horn of lateral meniscus)	0.466	0.534	0.000
M23.54 Chronic instability of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.466	0.534	0.000
M23.53 Chronic instability of knee (Medial collateral ligament or Other and unspecified medial meniscus)	0.466	0.534	0.000
M23.52 Chronic instability of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.466	0.534	0.000
M23.50 Chronic instability of knee (Multiple sites)	0.466	0.534	0.000
M30.8 Other conditions related to polyarteritis nodosa	0.465	0.534	0.001
M30.3 Mucocutaneous lymph node syndrome [Kawasaki]	0.465	0.534	0.001
M30.2 Juvenile polyarteritis	0.465	0.534	0.001
M30.1 Polyarteritis with lung involvement [Churg-Strauss]	0.465	0.534	0.001
M30.0 Polyarteritis nodosa	0.465	0.534	0.001
M32.9 Systemic lupus erythematosus, unspecified	0.465	0.534	0.001
M32.8 Other forms of systemic lupus erythematosus	0.465	0.534	0.001
M32.1 Systemic lupus erythematosus with organ or system involvement	0.465	0.534	0.001
M32.0 Drug-induced systemic lupus erythematosus	0.465	0.534	0.001
M33.9 Dermatopolymyositis, unspecified	0.465	0.534	0.001
M33.2 Polymyositis	0.465	0.534	0.001
M33.1 Other dermatomyositis	0.465	0.534	0.001
M33.0 Juvenile dermatomyositis	0.465	0.534	0.001
M36.8 Systemic disorders of connective tissue in other diseases classified elsewhere	0.465	0.534	0.001
M36.4 Arthropathy in hypersensitivity reactions classified elsewhere	0.465	0.534	0.001
M36.3 Arthropathy in other blood disorders	0.465	0.534	0.001
M36.2 Haemophilic arthropathy	0.465	0.534	0.001
M36.1 Arthropathy in neoplastic disease	0.465	0.534	0.001
M36.0 Dermato(poly)myositis in neoplastic disease	0.465	0.534	0.001
M71.3 Other bursal cyst	0.462	0.534	0.003
B35-B49 Mycoses	0.003	0.535	0.462

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations