TreeWAS – Variant ID: rs302972

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability
K90.0 Coeliac disease	1.000	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	1.000	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	1.000	0.000
# Top node	1.000	0.000
M20-M25 Other joint disorders	1.000	0.000
E00-E07 Disorders of thyroid gland	1.000	0.000
E05 Thyrotoxicosis [hyperthyroidism]	0.999	0.001
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.996	0.004
K90 Intestinal malabsorption	0.994	0.006
Chapter XI Diseases of the digestive system	0.994	0.006
K90-K93 Other diseases of the digestive system	0.993	0.007
M25 Other joint disorders, not elsewhere classified	0.993	0.007
E05.9 Thyrotoxicosis, unspecified	0.992	0.008
S90-S99 Injuries to the ankle and foot	0.991	0.009
E20-E35 Disorders of other endocrine glands	0.991	0.009
E10-E14 Diabetes mellitus	0.986	0.014
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.986	0.014
E10 Insulin-dependent diabetes mellitus	0.983	0.017
M25.7 Osteophyte	0.979	0.021
E05.0 Thyrotoxicosis with diffuse goitre	0.977	0.023
K80-K87 Disorders of gallbladder, biliary tract and pancreas	0.977	0.023
K80 Cholelithiasis	0.976	0.024
M15-M19 Arthrosis	0.964	0.036
E70-E90 Metabolic disorders	0.964	0.036
M05-M14 Inflammatory polyarthropathies	0.964	0.036
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.963	0.037
E10.9 Without complications	0.962	0.038
E27 Other disorders of adrenal gland	0.961	0.039
K80.5 Calculus of bile duct without cholangitis or cholecystitis	0.961	0.039
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.960	0.040
S92 Fracture of foot, except ankle	0.945	0.055
M25.77 Osteophyte (Ankle and foot)	0.944	0.056
M17 Gonarthrosis [arthrosis of knee]	0.943	0.057
M24 Other specific joint derangements	0.942	0.058
E10.3 With ophthalmic complications	0.935	0.065
D68 Other coagulation defects	0.933	0.067
M80-M85 Disorders of bone density and structure	0.932	0.068
E16 Other disorders of pancreatic internal secretion	0.932	0.068
M17.0 Primary gonarthrosis, bilateral	0.931	0.069
D60-D64 Aplastic and other anaemias	0.931	0.069
E80 Disorders of porphyrin and bilirubin metabolism	0.912	0.088
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level	0.911	0.089
K80.2 Calculus of gallbladder without cholecystitis	0.910	0.090
S00-S09 Injuries to the head	0.908	0.092
M23 Internal derangement of knee	0.907	0.093
Chapter V Mental and behavioural disorders	0.902	0.098
E16.2 Hypoglycaemia, unspecified	0.901	0.099
S92.3 Fracture of metatarsal bone	0.898	0.101
M35 Other systemic involvement of connective tissue	0.897	0.103
E03 Other hypothyroidism	0.895	0.105
E23 Hypofunction and other disorders of pituitary gland	0.892	0.108
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.887	0.113
F00-F09 Organic, including symptomatic, mental disorders	0.886	0.114
M18 Arthrosis of first carpometacarpal joint	0.882	0.118
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.880	0.120
E80.4 Gilbert's syndrome	0.874	0.126
E27.1 Primary adrenocortical insufficiency	0.874	0.126
M34 Systemic sclerosis	0.873	0.127
S90 Superficial injury of ankle and foot	0.870	0.130
M80 Osteoporosis with pathological fracture	0.869	0.131
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.867	0.133
S92.30 Fracture of metatarsal bone (closed)	0.865	0.135
M25.9 Joint disorder, unspecified	0.865	0.135
M23.3 Other meniscus derangements	0.864	0.136
S00 Superficial injury of head	0.864	0.136
M10 Gout	0.862	0.138
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.857	0.143
D68.8 Other specified coagulation defects	0.856	0.144
E27.4 Other and unspecified adrenocortical insufficiency	0.854	0.146
S70-S79 Injuries to the hip and thigh	0.837	0.163
M35.0 Sicca syndrome [Sjogren]	0.837	0.163
T66-T78 Other and unspecified effects of external causes	0.836	0.164
M25.6 Stiffness of joint, not elsewhere classified	0.833	0.167
E03.9 Hypothyroidism, unspecified	0.831	0.169
M25.76 Osteophyte (Lower leg)	0.831	0.169
K35-K38 Diseases of appendix	0.829	0.171
M65-M68 Disorders of synovium and tendon	0.825	0.175
K80.4 Calculus of bile duct with cholecystitis	0.820	0.180
M11 Other crystal arthropathies	0.818	0.182
D69 Purpura and other haemorrhagic conditions	0.817	0.183
M17.9 Gonarthrosis, unspecified	0.815	0.185
M24.0 Loose body in joint	0.808	0.192
E89.0 Postprocedural hypothyroidism	0.808	0.192
E88 Other metabolic disorders	0.805	0.195
K80.8 Other cholelithiasis	0.803	0.197
E24 Cushing's syndrome	0.801	0.199
D62 Acute posthaemorrhagic anaemia	0.800	0.200
M25.74 Osteophyte (Hand)	0.799	0.201
S92.4 Fracture of great toe	0.799	0.201
M80.9 Unspecified osteoporosis with pathological fracture	0.797	0.203
T92 Sequelae of injuries of upper limb	0.796	0.204
F05 Delirium, not induced by alcohol and other psychoactive substances	0.795	0.205
E29 Testicular dysfunction	0.795	0.205
E10.1 With ketoacidosis	0.795	0.205
S93.3 Dislocation of other and unspecified parts of foot	0.794	0.206
Chapter X Diseases of the respiratory system	0.793	0.207
F03 Unspecified dementia	0.790	0.210
S99 Other and unspecified injuries of ankle and foot	0.788	0.212
M24.4 Recurrent dislocation and subluxation of joint	0.787	0.213
E78 Disorders of lipoprotein metabolism and other lipidaemias	0.785	0.215
Chapter VII Diseases of the eye and adnexa	0.783	0.217
M13 Other arthritis	0.783	0.217
S00.1 Contusion of eyelid and periocular area	0.782	0.218
M86-M90 Other osteopathies	0.780	0.220
M81 Osteoporosis without pathological fracture	0.779	0.221
M25.3 Other instability of joint	0.779	0.221
D63 Anaemia in chronic diseases classified elsewhere	0.778	0.222
M25.71 Osteophyte (Shoulder region)	0.775	0.225
M25.4 Effusion of joint	0.774	0.226
M00-M03 Infectious arthropathies	0.773	0.227
K65-K67 Diseases of peritoneum	0.772	0.228
K82 Other diseases of gallbladder	0.772	0.228
M10.0 Idiopathic gout	0.771	0.229
M06 Other rheumatoid arthritis	0.771	0.229
E10.6 With other specified complications	0.771	0.229
M18.0 Primary arthrosis of first carpometacarpal joints, bilateral	0.770	0.230
H30-H36 Disorders of choroid and retina	0.766	0.234
M25.0 Haemarthrosis	0.766	0.234
D68.9 Coagulation defect, unspecified	0.764	0.235
T20-T25 Burns and corrosions of external body surface, specified by site	0.764	0.236
T00-T07 Injuries involving multiple body regions	0.764	0.236
D64 Other anaemias	0.759	0.241
E10.8 With unspecified complications	0.757	0.243
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.756	0.244
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.755	0.245
E16.1 Other hypoglycaemia	0.755	0.245
M23.32 Other meniscus derangements (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.755	0.245
M32 Systemic lupus erythematosus	0.755	0.245
Q60-Q64 Congenital malformations of the urinary system	0.754	0.246
M18.1 Other primary arthrosis of first carpometacarpal joint	0.754	0.246
T15-T19 Effects of foreign body entering through natural orifice	0.754	0.246
H35 Other retinal disorders	0.753	0.247
E23.7 Disorder of pituitary gland, unspecified	0.752	0.248
E27.2 Addisonian crisis	0.751	0.249
F06 Other mental disorders due to brain damage and dysfunction and to physical disease	0.751	0.249
E27.9 Disorder of adrenal gland, unspecified	0.750	0.250
D68.5 Primary Thrombophilia	0.749	0.251
M07 Psoriatic and enteropathic arthropathies	0.748	0.252
E34 Other endocrine disorders	0.748	0.252
M24.1 Other articular cartilage disorders	0.748	0.252
E20 Hypoparathyroidism	0.747	0.253
S91 Open wound of ankle and foot	0.747	0.253
M22 Disorders of patella	0.747	0.253
S70 Superficial injury of hip and thigh	0.746	0.254
E74 Other disorders of carbohydrate metabolism	0.746	0.254
S40-S49 Injuries to the shoulder and upper arm	0.744	0.256
S20-S29 Injuries to the thorax	0.744	0.256
S09 Other and unspecified injuries of head	0.743	0.257
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)	0.742	0.258
M23.30 Other meniscus derangements (Multiple sites)	0.742	0.258
E07 Other disorders of thyroid	0.742	0.258
S93.1 Dislocation of toe(s)	0.740	0.260
K80.0 Calculus of gallbladder with acute cholecystitis	0.740	0.260
M25.78 Osteophyte (Other)	0.738	0.262
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors	0.737	0.263
T78 Adverse effects, not elsewhere classified	0.737	0.263
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.736	0.264
M25.96 Joint disorder, unspecified (Lower leg)	0.735	0.265
F80-F89 Disorders of psychological development	0.732	0.268
E23.6 Other disorders of pituitary gland	0.730	0.270
K35 Acute appendicitis	0.730	0.270
M24.2 Disorder of ligament	0.727	0.273
M34.1 CR(E)ST syndrome	0.727	0.273
M80.90 Unspecified osteoporosis with pathological fracture (Multiple sites)	0.726	0.274
D68.3 Haemorrhagic disorder due to circulating anticoagulants	0.725	0.275
M23.36 Other meniscus derangements (Other and unspecified lateral meniscus)	0.725	0.275
D63.8 Anaemia in other chronic diseases classified elsewhere	0.723	0.277
S92.2 Fracture of other tarsal bone(s)	0.723	0.277
M60-M63 Disorders of muscles	0.722	0.277
D61 Other aplastic anaemias	0.722	0.278
S93.0 Dislocation of ankle joint	0.721	0.279
E73 Lactose intolerance	0.721	0.279
S10-S19 Injuries to the neck	0.721	0.279
S90.8 Other superficial injuries of ankle and foot	0.721	0.279
M23.8 Other internal derangements of knee	0.718	0.282
F07 Personality and behavioural disorders due to brain disease, damage and dysfunction	0.717	0.283
Chapter XVI Certain conditions originating in the perinatal period	0.717	0.283
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.717	0.283
M33 Dermatopolymyositis	0.717	0.283
M30 Polyarteritis nodosa and related conditions	0.717	0.283
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.717	0.283
E00 Congenital iodine-deficiency syndrome	0.717	0.283
E02 Subclinical iodine-deficiency hypothyroidism	0.717	0.283
E05.8 Other thyrotoxicosis	0.716	0.283
E05.5 Thyroid crisis or storm	0.716	0.283
E05.4 Thyrotoxicosis factitia	0.716	0.283
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.716	0.283
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.716	0.283
J95-J99 Other diseases of the respiratory system	0.715	0.285
M80.8 Other osteoporosis with pathological fracture	0.714	0.286
T33-T35 Frostbite	0.714	0.286
T26-T28 Burns and corrosions confined to eye and internal organs	0.714	0.286
K90.8 Other intestinal malabsorption	0.713	0.287
K90.3 Pancreatic steatorrhoea	0.713	0.287
K90.2 Blind loop syndrome, not elsewhere classified	0.713	0.287
K90.1 Tropical sprue	0.713	0.287
M11.2 Other chondrocalcinosis	0.713	0.287
S00.5 Superficial injury of lip and oral cavity	0.713	0.287
E28 Ovarian dysfunction	0.713	0.287
K93 Disorders of other digestive organs in diseases classified elsewhere	0.712	0.288
M25.2 Flail joint	0.712	0.288
M25.1 Fistula of joint	0.712	0.288
K00-K14 Diseases of oral cavity, salivary glands and jaws	0.711	0.289
H35.4 Peripheral retinal degeneration	0.711	0.289
S98 Traumatic amputation of ankle and foot	0.711	0.289
S97 Crushing injury of ankle and foot	0.711	0.289
S96 Injury of muscle and tendon at ankle and foot level	0.711	0.289
S95 Injury of blood vessels at ankle and foot level	0.711	0.289
S94 Injury of nerves at ankle and foot level	0.711	0.289
E35 Disorders of endocrine glands in diseases classified elsewhere	0.710	0.290
E32 Diseases of thymus	0.710	0.290
E31 Polyglandular dysfunction	0.710	0.290
E30 Disorders of puberty, not elsewhere classified	0.710	0.290
E26 Hyperaldosteronism	0.710	0.290
E25 Adrenogenital disorders	0.710	0.290
E89.3 Postprocedural hypopituitarism	0.710	0.290
S05 Injury of eye and orbit	0.708	0.292
E12 Malnutrition-related diabetes mellitus	0.707	0.293
D68.2 Hereditary deficiency of other clotting factors	0.707	0.293
E23.2 Diabetes insipidus	0.706	0.293
M10.07 Idiopathic gout (Ankle and foot)	0.706	0.294
M31 Other necrotising vasculopathies	0.706	0.294
E10.7 With multiple complications	0.705	0.295
E10.0 With coma	0.705	0.295
J00-J06 Acute upper respiratory infections	0.704	0.296
Chapter XXII Codes for special purposes	0.704	0.296
M25.72 Osteophyte (Upper arm)	0.704	0.296
S00.7 Multiple superficial injuries of head	0.704	0.296
M25.79 Osteophyte (Site unspecified)	0.702	0.298
M25.73 Osteophyte (Forearm)	0.702	0.298
M25.70 Osteophyte (Multiple sites)	0.702	0.298
M23.5 Chronic instability of knee	0.702	0.298
S90.3 Contusion of other and unspecified parts of foot	0.701	0.299
T92.5 Sequelae of injury of muscle and tendon of upper limb	0.701	0.299
K87 Disorders of gallbladder, biliary tract and pancreas in diseases classified elsewhere	0.700	0.300
M17.5 Other secondary gonarthrosis	0.700	0.300
K80.3 Calculus of bile duct with cholangitis	0.699	0.300
M91-M94 Chondropathies	0.699	0.301
M23.39 Other meniscus derangements (Unspecified ligament or Unspecified meniscus)	0.697	0.303
J90-J94 Other diseases of pleura	0.696	0.304
E78.9 Disorder of lipoprotein metabolism, unspecified	0.696	0.304
D80-D89 Certain disorders involving the immune mechanism	0.696	0.304
F01 Vascular dementia	0.694	0.306
E06 Thyroiditis	0.692	0.308
D68.6 Other Thrombophilia	0.692	0.308
F60-F69 Disorders of adult personality and behaviour	0.692	0.308
M25.97 Joint disorder, unspecified (Ankle and foot)	0.692	0.308
M15 Polyarthrosis	0.691	0.308
E85 Amyloidosis	0.691	0.309
E84 Cystic fibrosis	0.691	0.309
E79 Disorders of purine and pyrimidine metabolism	0.691	0.309
E77 Disorders of glycoprotein metabolism	0.691	0.309
E76 Disorders of glycosaminoglycan metabolism	0.691	0.309
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.691	0.309
E72 Other disorders of amino-acid metabolism	0.691	0.309
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.691	0.309
E70 Disorders of aromatic amino-acid metabolism	0.691	0.309
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.691	0.309
M14 Arthropathies in other diseases classified elsewhere	0.691	0.309
M12 Other specific arthropathies	0.691	0.309
M09 Juvenile arthritis in diseases classified elsewhere	0.691	0.309
M08 Juvenile arthritis	0.691	0.309
S92.1 Fracture of talus	0.691	0.309
D67 Hereditary factor IX deficiency	0.690	0.309
D66 Hereditary factor VIII deficiency	0.690	0.309
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.690	0.309
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified	0.691	0.309
E27.8 Other specified disorders of adrenal gland	0.689	0.311
E27.5 Adrenomedullary hyperfunction	0.689	0.311
E27.3 Drug-induced adrenocortical insufficiency	0.689	0.311
E27.0 Other adrenocortical overactivity	0.689	0.311
T90 Sequelae of injuries of head	0.689	0.311
E15 Nondiabetic hypoglycaemic coma	0.688	0.311
M24.8 Other specific joint derangements, not elsewhere classified	0.688	0.312
M24.5 Contracture of joint	0.688	0.312
F05.8 Other delirium	0.687	0.313
M89 Other disorders of bone	0.686	0.314
M34.9 Systemic sclerosis, unspecified	0.685	0.314
J92 Pleural plaque	0.685	0.315
M65 Synovitis and tenosynovitis	0.684	0.316
S00.9 Superficial injury of head, part unspecified	0.683	0.317
D55-D59 Haemolytic anaemias	0.681	0.319
S00.2 Other superficial injuries of eyelid and periocular area	0.681	0.319
E13 Other specified diabetes mellitus	0.679	0.320
F02 Dementia in other diseases classified elsewhere	0.678	0.322
S92.9 Fracture of foot, unspecified	0.677	0.322
S92.7 Multiple fractures of foot	0.677	0.322
S92.5 Fracture of other toe	0.677	0.322
M17.3 Other posttraumatic gonarthrosis	0.677	0.323
M23.6 Other spontaneous disruption of ligament(s) of knee	0.677	0.323
K82.9 Disease of gallbladder, unspecified	0.677	0.323
H35.8 Other specified retinal disorders	0.677	0.323
M24.41 Recurrent dislocation and subluxation of joint (Shoulder region)	0.676	0.324
M17.4 Other secondary gonarthrosis, bilateral	0.676	0.324
M17.2 Posttraumatic gonarthrosis, bilateral	0.676	0.324
M25.8 Other specified joint disorders	0.676	0.324
M24.9 Joint derangement, unspecified	0.675	0.325
M24.7 Protrusio acetabuli	0.675	0.325
M24.6 Ankylosis of joint	0.675	0.325
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.675	0.325
H15-H22 Disorders of sclera, cornea, iris and ciliary body	0.675	0.325
M24.02 Loose body in joint (Upper arm)	0.675	0.325
H35.7 Separation of retinal layers	0.675	0.325
T79-T79 Certain early complications of trauma	0.674	0.326
M24.15 Other articular cartilage disorders (Pelvic region and thigh)	0.674	0.326
T94 Sequelae of injuries involving multiple and unspecified body regions	0.673	0.326
T91 Sequelae of injuries of neck and trunk	0.673	0.327
S92.41 Fracture of great toe (open)	0.673	0.327
J40-J47 Chronic lower respiratory diseases	0.672	0.328
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.671	0.329
M35.1 Other overlap syndromes	0.671	0.329
M21 Other acquired deformities of limbs	0.671	0.329
M34.8 Other forms of systemic sclerosis	0.671	0.329
K65 Peritonitis	0.669	0.331
D68.4 Acquired coagulation factor deficiency	0.669	0.331
D68.1 Hereditary factor XI deficiency	0.669	0.331
M23.35 Other meniscus derangements (Posterior horn of lateral meniscus)	0.669	0.331
T92.9 Sequelae of unspecified injury of upper limb	0.668	0.332
M83 Adult osteomalacia	0.668	0.332
E16.9 Disorder of pancreatic internal secretion, unspecified	0.668	0.332
E16.8 Other specified disorders of pancreatic internal secretion	0.668	0.332
E16.4 Abnormal secretion of gastrin	0.668	0.332
E16.3 Increased secretion of glucagon	0.668	0.332
E16.0 Drug-induced hypoglycaemia without coma	0.668	0.332
D68.0 Von Willebrand's disease	0.668	0.332
Q60 Renal agenesis and other reduction defects of kidney	0.668	0.332
D60 Acquired pure red cell aplasia [erythroblastopenia]	0.667	0.333
M40-M43 Deforming dorsopathies	0.667	0.333
K90.4 Malabsorption due to intolerance, not elsewhere classified	0.667	0.333
M10.9 Gout, unspecified	0.667	0.333
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.664	0.336
E10.4 With neurological complications	0.663	0.337
J92.0 Pleural plaque with presence of asbestos	0.663	0.337
M81.9 Osteoporosis, unspecified	0.662	0.338
F05.9 Delirium, unspecified	0.661	0.339
S90.9 Superficial injury of ankle and foot, unspecified	0.660	0.340
K38 Other diseases of appendix	0.659	0.341
E14 Unspecified diabetes mellitus	0.658	0.342
M80.5 Idiopathic osteoporosis with pathological fracture	0.656	0.344
E24.0 Pituitary-dependent Cushing's disease	0.655	0.345
E29.1 Testicular hypofunction	0.655	0.345
F06.7 Mild cognitive disorder	0.654	0.345
S00.3 Superficial injury of nose	0.654	0.346
K36 Other appendicitis	0.654	0.346
E80.7 Disorder of bilirubin metabolism, unspecified	0.654	0.346
E80.6 Other disorders of bilirubin metabolism	0.654	0.346
E80.5 Crigler-Najjar syndrome	0.654	0.346
E80.3 Defects of catalase and peroxydase	0.654	0.346
E80.2 Other porphyria	0.654	0.346
E80.1 Porphyria cutanea tarda	0.654	0.346
E80.0 Hereditary erythropoietic porphyria	0.654	0.346
S93.4 Sprain and strain of ankle	0.653	0.347
S93.6 Sprain and strain of other and unspecified parts of foot	0.653	0.347
S93.5 Sprain and strain of toe(s)	0.653	0.347
S93.2 Rupture of ligaments at ankle and foot level	0.653	0.347
T78.2 Anaphylactic shock, unspecified	0.653	0.347
E10.2 With renal complications	0.653	0.347
K35.9 Acute appendicitis, unspecified	0.653	0.347
E78.2 Mixed hyperlipidaemia	0.652	0.348
M85 Other disorders of bone density and structure	0.652	0.348
M23.9 Internal derangement of knee, unspecified	0.651	0.349
S08 Traumatic amputation of part of head	0.651	0.349
S07 Crushing injury of head	0.651	0.349
S04 Injury of cranial nerves	0.651	0.349
S03 Dislocation, sprain and strain of joints and ligaments of head	0.651	0.349
Chapter XX External causes of morbidity and mortality	0.651	0.349
M23.1 Discoid meniscus (congenital)	0.650	0.350
M23.0 Cystic meniscus	0.650	0.350
M82 Osteoporosis in diseases classified elsewhere	0.650	0.350
M23.4 Loose body in knee	0.650	0.350
E78.4 Other hyperlipidaemia	0.650	0.350
M80.1 Postoophorectomy osteoporosis with pathological fracture	0.649	0.351
S02 Fracture of skull and facial bones	0.649	0.351
M06.9 Rheumatoid arthritis, unspecified	0.648	0.352
S71 Open wound of hip and thigh	0.648	0.352
H43-H45 Disorders of vitreous body and globe	0.648	0.352
F99-F99 Unspecified mental disorder	0.647	0.353
Q50-Q56 Congenital malformations of genital organs	0.647	0.353
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence	0.646	0.353
F70-F79 Mental retardation	0.646	0.353
K11 Diseases of salivary glands	0.646	0.354
S92.31 Fracture of metatarsal bone (open)	0.644	0.356
M35.9 Systemic involvement of connective tissue, unspecified	0.643	0.357
M35.8 Other specified systemic involvement of connective tissue	0.643	0.357
M35.7 Hypermobility syndrome	0.643	0.357
M35.6 Relapsing panniculitis [Weber-Christian]	0.643	0.357
M35.5 Multifocal fibrosclerosis	0.643	0.357
M35.4 Diffuse (eosinophilic) fasciitis	0.643	0.357
M35.2 Behcet's disease	0.643	0.357
M24.01 Loose body in joint (Shoulder region)	0.643	0.357
Q00-Q07 Congenital malformations of the nervous system	0.643	0.357
D69.3 Idiopathic thrombocytopenic purpura	0.643	0.357
S99.9 Unspecified injury of ankle and foot	0.642	0.358
E03.5 Myxoedema coma	0.642	0.358
E03.4 Atrophy of thyroid (acquired)	0.642	0.358
E03.3 Postinfectious hypothyroidism	0.642	0.358
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.642	0.358
E03.1 Congenital hypothyroidism without goitre	0.642	0.358
E03.0 Congenital hypothyroidism with diffuse goitre	0.642	0.358
H31 Other disorders of choroid	0.642	0.358
Chapter XII Diseases of the skin and subcutaneous tissue	0.641	0.359
Q80-Q89 Other congenital malformations	0.640	0.359
E10.5 With peripheral circulatory complications	0.640	0.360
K02 Dental caries	0.640	0.360
E23.3 Hypothalamic dysfunction, not elsewhere classified	0.639	0.360
E23.1 Drug-induced hypopituitarism	0.639	0.360
M11.26 Other chondrocalcinosis (Lower leg)	0.638	0.362
D70-D77 Other diseases of blood and blood-forming organs	0.637	0.363
D69.6 Thrombocytopenia, unspecified	0.636	0.364
M25.33 Other instability of joint (Forearm)	0.636	0.364
T95 Sequelae of burns, corrosions and frostbite	0.636	0.364
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source	0.636	0.364
T96 Sequelae of poisoning by drugs, medicaments and biological substances	0.636	0.364
D64.9 Anaemia, unspecified	0.636	0.364
F09 Unspecified organic or symptomatic mental disorder	0.635	0.365
F04 Organic amnesic syndrome, not induced by alcohol and other psychoactive substances	0.635	0.365
K50-K52 Noninfective enteritis and colitis	0.634	0.366
J02 Acute pharyngitis	0.634	0.366
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.633	0.367
M18.5 Other secondary arthrosis of first carpometacarpal joint	0.633	0.367
M18.4 Other secondary arthrosis of first carpometacarpal joints, bilateral	0.633	0.367
M18.3 Other posttraumatic arthrosis of first carpometacarpal joint	0.633	0.367
M18.2 Posttraumatic arthrosis of first carpometacarpal joints, bilateral	0.633	0.367
M80.98 Unspecified osteoporosis with pathological fracture (Other)	0.632	0.368
S70.1 Contusion of thigh	0.631	0.369
E89.9 Postprocedural endocrine and metabolic disorder, unspecified	0.631	0.369
E89.8 Other postprocedural endocrine and metabolic disorders	0.631	0.369
E89.6 Postprocedural adrenocortical(-medullary) hypofunction	0.631	0.369
E89.5 Postprocedural testicular hypofunction	0.631	0.369
E89.4 Postprocedural ovarian failure	0.631	0.369
E89.1 Postprocedural hypoinsulinaemia	0.631	0.369
E78.1 Pure hyperglyceridaemia	0.629	0.371
M18.9 Arthrosis of first carpometacarpal joint, unspecified	0.627	0.373
M96 Postprocedural musculoskeletal disorders, not elsewhere classified	0.627	0.373
M25.75 Osteophyte (Pelvic region and thigh)	0.626	0.374
M34.2 Systemic sclerosis induced by drugs and chemicals	0.626	0.374
M34.0 Progressive systemic sclerosis	0.626	0.374
K35.1 Acute appendicitis with peritoneal abscess	0.625	0.374
S09.9 Unspecified injury of head	0.625	0.375
T92.3 Sequelae of dislocation, sprain and strain of upper limb	0.625	0.375
S90.7 Multiple superficial injuries of ankle and foot	0.624	0.376
S90.2 Contusion of toe(s) with damage to nail	0.624	0.376
S90.1 Contusion of toe(s) without damage to nail	0.624	0.376
S90.0 Contusion of ankle	0.624	0.376
M80.4 Drug-induced osteoporosis with pathological fracture	0.623	0.377
M80.3 Postsurgical malabsorption osteoporosis with pathological fracture	0.623	0.377
M80.2 Osteoporosis of disuse with pathological fracture	0.623	0.377
E50-E64 Other nutritional deficiencies	0.622	0.377
S29 Other and unspecified injuries of thorax	0.622	0.378
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.621	0.378
Q35-Q37 Cleft lip and cleft palate	0.621	0.378
Q30-Q34 Congenital malformations of the respiratory system	0.621	0.378
M13.9 Arthritis, unspecified	0.620	0.380
E23.0 Hypopituitarism	0.620	0.380
M25.99 Joint disorder, unspecified (Site unspecified)	0.620	0.380
M25.98 Joint disorder, unspecified (Other)	0.620	0.380
M25.95 Joint disorder, unspecified (Pelvic region and thigh)	0.620	0.380
M25.94 Joint disorder, unspecified (Hand)	0.620	0.380
M25.93 Joint disorder, unspecified (Forearm)	0.620	0.380
M25.92 Joint disorder, unspecified (Upper arm)	0.620	0.380
M25.91 Joint disorder, unspecified (Shoulder region)	0.620	0.380
M25.90 Joint disorder, unspecified (Multiple sites)	0.620	0.380
M23.37 Other meniscus derangements-Capsular lig	0.620	0.380
S00.4 Superficial injury of ear	0.620	0.380
J06 Acute upper respiratory infections of multiple and unspecified sites	0.620	0.380
D69.9 Haemorrhagic condition, unspecified	0.619	0.381
Q38-Q45 Other congenital malformations of the digestive system	0.619	0.381
M23.80 Other internal derangements of knee (Multiple sites)	0.619	0.381
M84 Disorders of continuity of bone	0.619	0.381
M10.4 Other secondary gout	0.618	0.382
M10.3 Gout due to impairment of renal function	0.618	0.382
M10.2 Drug-induced gout	0.618	0.382
M10.1 Lead-induced gout	0.618	0.382
M23.31 Other meniscus derangements (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.618	0.382
T98 Sequelae of other and unspecified effects of external causes	0.617	0.383
E40-E46 Malnutrition	0.616	0.384
M05 Seropositive rheumatoid arthritis	0.615	0.385
F20-F29 Schizophrenia, schizotypal and delusional disorders	0.613	0.387
M67 Other disorders of synovium and tendon	0.613	0.387
J98 Other respiratory disorders	0.612	0.388
S50-S59 Injuries to the elbow and forearm	0.611	0.388
S06 Intracranial injury	0.611	0.389
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.611	0.389
K85 Acute pancreatitis	0.611	0.389
M00 Pyogenic arthritis	0.610	0.389
J92.9 Pleural plaque without asbestos	0.610	0.390
S92.40 Fracture of great toe (closed)	0.610	0.390
K80.1 Calculus of gallbladder with other cholecystitis	0.610	0.390
T78.3 Angioneurotic oedema	0.609	0.391
M81.99 Osteoporosis, unspecified (Site unspecified)	0.607	0.393
D69.0 Allergic purpura	0.607	0.393
S21 Open wound of thorax	0.606	0.394
M25.46 Effusion of joint (Lower leg)	0.606	0.394
K82.2 Perforation of gallbladder	0.605	0.395
M13.0 Polyarthritis, unspecified	0.605	0.395
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.604	0.396
M19 Other arthrosis	0.604	0.396
M25.06 Haemarthrosis (Lower leg)	0.603	0.397
M80.81 Other osteoporosis with pathological fracture (Shoulder region)	0.603	0.397
M13.97 Arthritis, unspecified (Ankle and foot)	0.602	0.398

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations