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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3131294
log Bayes Factor = 141.578
Chromosome 6   position 32,180,146  (GRCh37) Explore rs3131294 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
H36.0 Diabetic retinopathy
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
Chapter IX Diseases of the circulatory system
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
# Top node
0.000 0.000 1.000
E78.0 Pure hypercholesterolaemia
0.000 0.000 1.000
I10 Essential (primary) hypertension
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
I10-I15 Hypertensive diseases
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
Chapter VII Diseases of the eye and adnexa
0.000 0.000 1.000
E10.1 With ketoacidosis
0.000 0.000 1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
H30-H36 Disorders of choroid and retina
0.000 0.000 1.000
H36 Retinal disorders in diseases classified elsewhere
0.000 0.000 1.000
I20 Angina pectoris
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
L40-L45 Papulosquamous disorders
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
L40 Psoriasis
0.000 0.000 1.000
L43 Lichen planus
0.000 0.001 0.999
M06 Other rheumatoid arthritis
0.000 0.001 0.999
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.001 0.999
L43.9 Lichen planus, unspecified
0.000 0.001 0.999
E16 Other disorders of pancreatic internal secretion
0.000 0.001 0.999
E83.1 Disorders of iron metabolism
0.998 0.002 0.000
E16.2 Hypoglycaemia, unspecified
0.000 0.002 0.998
M05-M14 Inflammatory polyarthropathies
0.000 0.002 0.998
L40.5 Arthropathic psoriasis
0.000 0.003 0.997
H40-H42 Glaucoma
0.000 0.003 0.997
G35-G37 Demyelinating diseases of the central nervous system
0.997 0.003 0.000
E10.4 With neurological complications
0.000 0.004 0.996
H40 Glaucoma
0.000 0.005 0.995
H40.9 Glaucoma, unspecified
0.000 0.005 0.995
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.005 0.995
E14.9 Without complications
0.000 0.006 0.994
I20.9 Angina pectoris, unspecified
0.000 0.006 0.994
G37 Other demyelinating diseases of central nervous system
0.994 0.006 0.000
E70-E90 Metabolic disorders
0.000 0.006 0.994
M05 Seropositive rheumatoid arthritis
0.000 0.007 0.993
I25.1 Atherosclerotic heart disease
0.000 0.008 0.992
Chapter XI Diseases of the digestive system
0.000 0.008 0.992
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.008 0.992
K90 Intestinal malabsorption
0.000 0.009 0.991
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.010 0.990
K90-K93 Other diseases of the digestive system
0.000 0.010 0.990
I20.0 Unstable angina
0.000 0.011 0.989
E14.3 With ophthalmic complications
0.000 0.012 0.988
G37.9 Demyelinating disease of central nervous system, unspecified
0.987 0.013 0.000
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.020 0.980
L40.9 Psoriasis, unspecified
0.000 0.020 0.980
I22 Subsequent myocardial infarction
0.000 0.021 0.979
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.028 0.972
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.028 0.972
E10.5 With peripheral circulatory complications
0.000 0.033 0.967
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.034 0.966
I24 Other acute ischaemic heart diseases
0.000 0.035 0.965
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.037 0.963
H34 Retinal vascular occlusions
0.000 0.039 0.961
E11.3 With ophthalmic complications
0.000 0.040 0.960
I12 Hypertensive renal disease
0.000 0.041 0.959
K70-K77 Diseases of liver
0.000 0.042 0.958
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.044 0.956
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.047 0.953
H43-H45 Disorders of vitreous body and globe
0.000 0.050 0.950
K80-K87 Disorders of gallbladder, biliary tract and pancreas
0.000 0.054 0.946
I21 Acute myocardial infarction
0.000 0.054 0.946
J45.9 Asthma, unspecified
0.000 0.057 0.943
K74 Fibrosis and cirrhosis of liver
0.000 0.062 0.938
E11.1 With ketoacidosis
0.000 0.063 0.937
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.066 0.934
H43 Disorders of vitreous body
0.000 0.066 0.934
I25.5 Ischaemic cardiomyopathy
0.000 0.067 0.933
E07 Other disorders of thyroid
0.000 0.071 0.929
H40.1 Primary open-angle glaucoma
0.000 0.073 0.927
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.077 0.923
K74.3 Primary biliary cirrhosis
0.000 0.080 0.920
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.081 0.919
I25.2 Old myocardial infarction
0.000 0.081 0.919
K82 Other diseases of gallbladder
0.000 0.085 0.915
I12.9 Hypertensive renal disease without renal failure
0.000 0.090 0.910
H34.2 Other retinal artery occlusions
0.000 0.092 0.908
I20.1 Angina pectoris with documented spasm
0.000 0.092 0.908
I21.9 Acute myocardial infarction, unspecified
0.000 0.098 0.902
K82.8 Other specified diseases of gallbladder
0.000 0.098 0.902
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.100 0.900
I30-I52 Other forms of heart disease
0.000 0.101 0.899
K51.9 Ulcerative colitis, unspecified
0.891 0.109 0.000
E07.9 Disorder of thyroid, unspecified
0.000 0.111 0.889
E13 Other specified diabetes mellitus
0.000 0.111 0.889
G37.8 Other specified demyelinating diseases of central nervous system
0.888 0.112 0.000
K81 Cholecystitis
0.000 0.113 0.887
I35 Nonrheumatic aortic valve disorders
0.000 0.118 0.882
K51 Ulcerative colitis
0.881 0.118 0.001
I35.0 Aortic (valve) stenosis
0.000 0.120 0.880
H43.8 Other disorders of vitreous body
0.000 0.121 0.879
I47 Paroxysmal tachycardia
0.000 0.122 0.878
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.122 0.878
M07 Psoriatic and enteropathic arthropathies
0.000 0.124 0.876
E11.2 With renal complications
0.000 0.124 0.876
K80.2 Calculus of gallbladder without cholecystitis
0.000 0.129 0.871
K80 Cholelithiasis
0.000 0.131 0.869
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.132 0.868
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.134 0.866
H43.3 Other vitreous opacities
0.000 0.136 0.864
I47.1 Supraventricular tachycardia
0.000 0.143 0.857
E03.8 Other specified hypothyroidism
0.000 0.144 0.856
E10.2 With renal complications
0.000 0.144 0.856
K51.3 Ulcerative (chronic) rectosigmoiditis
0.856 0.144 0.000
M06.3 Rheumatoid nodule
0.000 0.145 0.855
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.146 0.854
E11.5 With peripheral circulatory complications
0.000 0.153 0.847
M45-M49 Spondylopathies
0.000 0.156 0.844
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.157 0.843
K81.1 Chronic cholecystitis
0.000 0.161 0.839
E06 Thyroiditis
0.000 0.165 0.835
M06.4 Inflammatory polyarthropathy
0.000 0.166 0.834
M45 Ankylosing spondylitis
0.000 0.167 0.833
K81.9 Cholecystitis, unspecified
0.000 0.170 0.830
I46 Cardiac arrest
0.000 0.173 0.827
I15 Secondary hypertension
0.000 0.176 0.824
K72 Hepatic failure, not elsewhere classified
0.000 0.177 0.823
I21.4 Acute subendocardial myocardial infarction
0.000 0.180 0.820
H34.8 Other retinal vascular occlusions
0.000 0.181 0.819
E78.2 Mixed hyperlipidaemia
0.000 0.183 0.817
I31 Other diseases of pericardium
0.000 0.183 0.817
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.185 0.815
K51.8 Other ulcerative colitis
0.814 0.186 0.000
K75 Other inflammatory liver diseases
0.000 0.186 0.814
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.188 0.812
E13.9 Without complications
0.000 0.191 0.809
Chapter VIII Diseases of the ear and mastoid process
0.000 0.194 0.806
E74 Other disorders of carbohydrate metabolism
0.000 0.196 0.804
K50-K52 Noninfective enteritis and colitis
0.041 0.206 0.753
I12.0 Hypertensive renal disease with renal failure
0.000 0.206 0.794
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.207 0.793
E05.9 Thyrotoxicosis, unspecified
0.000 0.207 0.793
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.208 0.792
M07.3 Other psoriatic arthropathies
0.000 0.211 0.789
K73 Chronic hepatitis, not elsewhere classified
0.000 0.212 0.788
I46.9 Cardiac arrest, unspecified
0.000 0.213 0.787
Chapter VI Diseases of the nervous system
0.782 0.215 0.003
H40.5 Glaucoma secondary to other eye disorders
0.000 0.217 0.783
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.217 0.783
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.220 0.780
H25-H28 Disorders of lens
0.000 0.224 0.776
E11.4 With neurological complications
0.000 0.226 0.774
L40.8 Other psoriasis
0.000 0.226 0.773
K74.6 Other and unspecified cirrhosis of liver
0.000 0.227 0.773
E16.1 Other hypoglycaemia
0.000 0.228 0.772
E83 Disorders of mineral metabolism
0.696 0.231 0.074
E78.8 Other disorders of lipoprotein metabolism
0.000 0.231 0.769
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.768 0.232 0.000
H53-H54 Visual disturbances and blindness
0.000 0.233 0.767
I25.3 Aneurysm of heart
0.000 0.236 0.764
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.000 0.237 0.762
M11 Other crystal arthropathies
0.000 0.240 0.760
H60-H62 Diseases of external ear
0.000 0.242 0.758
K51.5 Mucosal proctocolitis
0.758 0.242 0.000
I23 Certain current complications following acute myocardial infarction
0.000 0.243 0.757
L43.8 Other lichen planus
0.000 0.245 0.755
I51 Complications and ill-defined descriptions of heart disease
0.000 0.246 0.754
E11.0 With coma
0.000 0.249 0.751
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.250 0.750
E40-E46 Malnutrition
0.000 0.251 0.749
E06.3 Autoimmune thyroiditis
0.000 0.251 0.749
G80-G83 Cerebral palsy and other paralytic syndromes
0.745 0.254 0.001
I25.4 Coronary artery aneurysm
0.000 0.254 0.746
E14.4 With neurological complications
0.000 0.256 0.744
E78.1 Pure hyperglyceridaemia
0.000 0.260 0.740
I51.8 Other ill-defined heart diseases
0.000 0.260 0.740
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.261 0.739
K82.1 Hydrops of gallbladder
0.000 0.263 0.737
M06.34 Rheumatoid nodule (Hand)
0.000 0.265 0.735
H27 Other disorders of lens
0.000 0.266 0.734
H30 Chorioretinal inflammation
0.000 0.268 0.732
I31.3 Pericardial effusion (noninflammatory)
0.000 0.268 0.732
Q60-Q64 Congenital malformations of the urinary system
0.000 0.270 0.730
H43.9 Disorder of vitreous body, unspecified
0.000 0.270 0.730
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.271 0.729
K75.4 Autoimmune hepatitis
0.000 0.274 0.726
L42 Pityriasis rosea
0.000 0.276 0.724
Q61 Cystic kidney disease
0.000 0.280 0.720
E10.8 With unspecified complications
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E10.6 With other specified complications
0.000 0.283 0.717
E10.0 With coma
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
I13 Hypertensive heart and renal disease
0.000 0.283 0.717
I00-I02 Acute rheumatic fever
0.000 0.283 0.717
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.1 Congenital hypothyroidism without goitre
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.283 0.717
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.283 0.717
E14.8 With unspecified complications
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E14.6 With other specified complications
0.000 0.283 0.717
E14.5 With peripheral circulatory complications
0.000 0.283 0.717
E14.2 Withrenal complications
0.000 0.283 0.717
E14.1 With ketoacidosis
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
L44 Other papulosquamous disorders
0.000 0.283 0.717
L41 Parapsoriasis
0.000 0.283 0.717
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.000 0.283 0.717
L40.3 Pustulosis palmaris et plantaris
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
L40.1 Generalised pustular psoriasis
0.000 0.283 0.717
L43.3 Subacute (active) lichen planus
0.000 0.283 0.716
L43.2 Lichenoid drug reaction
0.000 0.283 0.716
L43.1 Bullous lichen planus
0.000 0.283 0.716
L43.0 Hypertrophic lichen planus
0.000 0.283 0.716
M06.8 Other specified rheumatoid arthritis
0.000 0.283 0.716
M06.2 Rheumatoid bursitis
0.000 0.283 0.716
M06.1 Adult-onset Still's disease
0.000 0.283 0.716
E15 Nondiabetic hypoglycaemic coma
0.000 0.284 0.716
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.284 0.716
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.284 0.716
E16.4 Abnormal secretion of gastrin
0.000 0.284 0.716
E16.3 Increased secretion of glucagon
0.000 0.284 0.716
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.285 0.715
M08 Juvenile arthritis
0.000 0.285 0.715
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.285 0.715
H42 Glaucoma in diseases classified elsewhere
0.000 0.285 0.715
G36 Other acute disseminated demyelination
0.715 0.285 0.000
H40.6 Glaucoma secondary to drugs
0.000 0.286 0.714
H40.4 Glaucoma secondary to eye inflammation
0.000 0.286 0.714
H40.3 Glaucoma secondary to eye trauma
0.000 0.286 0.714
E78.6 Lipoprotein deficiency
0.000 0.287 0.713
E78.3 Hyperchylomicronaemia
0.000 0.287 0.713
K55-K64 Other diseases of intestines
0.000 0.287 0.713
E11.6 With other specified complications
0.000 0.287 0.713
G37.5 Concentric sclerosis [Balo]
0.713 0.287 0.000
G37.4 Subacute necrotising myelitis
0.713 0.287 0.000
G37.2 Central pontine myelinolysis
0.713 0.287 0.000
G37.1 Central demyelination of corpus callosum
0.713 0.287 0.000
G37.0 Diffuse sclerosis
0.713 0.287 0.000
E77 Disorders of glycoprotein metabolism
0.000 0.287 0.712
E76 Disorders of glycosaminoglycan metabolism
0.000 0.287 0.712
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.287 0.712
E72 Other disorders of amino-acid metabolism
0.000 0.287 0.712
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.287 0.712
E70 Disorders of aromatic amino-acid metabolism
0.000 0.287 0.712
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.287 0.712
M05.8 Other seropositive rheumatoid arthritis
0.000 0.288 0.712
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.288 0.712
M05.2 Rheumatoid vasculitis
0.000 0.288 0.712
M05.1 Rheumatoid lung disease
0.000 0.288 0.712
M05.0 Felty's syndrome
0.000 0.288 0.712
H65-H75 Diseases of middle ear and mastoid
0.000 0.288 0.712
G20-G26 Extrapyramidal and movement disorders
0.711 0.289 0.001
K90.3 Pancreatic steatorrhoea
0.000 0.289 0.710
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.289 0.710
K90.1 Tropical sprue
0.000 0.289 0.710
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.290 0.710
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.290 0.710
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.290 0.710
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.290 0.710
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.290 0.710
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.290 0.710
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.290 0.710
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.290 0.710
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.290 0.709
K60 Fissure and fistula of anal and rectal regions
0.000 0.294 0.706
H43.2 Crystalline deposits in vitreous body
0.000 0.297 0.703
I35.8 Other aortic valve disorders
0.000 0.297 0.703
K82.2 Perforation of gallbladder
0.000 0.298 0.702
I31.9 Disease of pericardium, unspecified
0.000 0.300 0.700
I47.9 Paroxysmal tachycardia, unspecified
0.000 0.301 0.699
H61 Other disorders of external ear
0.000 0.301 0.699
E88 Other metabolic disorders
0.000 0.302 0.698
K74.5 Biliary cirrhosis, unspecified
0.000 0.302 0.698
K60.2 Anal fissure, unspecified
0.000 0.303 0.697
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.307 0.693
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.310 0.690
I24.8 Other forms of acute ischaemic heart disease
0.000 0.310 0.690
G81 Hemiplegia
0.689 0.311 0.000
H34.9 Retinal vascular occlusion, unspecified
0.000 0.311 0.689
H34.1 Central retinal artery occlusion
0.000 0.311 0.689
H34.0 Transient retinal artery occlusion
0.000 0.311 0.689
K77 Liver disorders in diseases classified elsewhere
0.000 0.313 0.687
K71 Toxic liver disease
0.000 0.313 0.687
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.315 0.685
I15.1 Hypertension secondary to other renal disorders
0.000 0.315 0.684
K72.9 Hepatic failure, unspecified
0.000 0.316 0.684
K55 Vascular disorders of intestine
0.000 0.318 0.682
H45 Disorders of vitreous body and globe in diseases classified elsewhere
0.000 0.319 0.681
K87 Disorders of gallbladder, biliary tract and pancreas in diseases classified elsewhere
0.000 0.321 0.679
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.322 0.678
M06.0 Seronegative rheumatoid arthritis
0.000 0.322 0.678
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.322 0.678
G83 Other paralytic syndromes
0.677 0.323 0.000
H35 Other retinal disorders
0.000 0.324 0.676
E79 Disorders of purine and pyrimidine metabolism
0.000 0.324 0.675
E84 Cystic fibrosis
0.000 0.325 0.675
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.325 0.675
K74.4 Secondary biliary cirrhosis
0.000 0.327 0.673
K74.2 Hepatic fibrosis with hepatic sclerosis
0.000 0.327 0.673
K74.1 Hepatic sclerosis
0.000 0.327 0.673
L40.0 Psoriasis vulgaris
0.000 0.329 0.671
H43.0 Vitreous prolapse
0.000 0.330 0.669
M65-M68 Disorders of synovium and tendon
0.000 0.330 0.670
G30-G32 Other degenerative diseases of the nervous system
0.667 0.332 0.001
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.332 0.668
E07.1 Dyshormogenetic goitre
0.000 0.334 0.666
E07.0 Hypersecretion of calcitonin
0.000 0.334 0.666
G20 Parkinson's disease
0.666 0.334 0.000
K50 Crohn's disease [regional enteritis]
0.002 0.336 0.662
E11.8 With unspecified complications
0.000 0.336 0.663
Q61.0 Congenital single renal cyst
0.000 0.337 0.663
H71 Cholesteatoma of middle ear
0.000 0.339 0.661
K72.0 Acute and subacute hepatic failure
0.000 0.339 0.661
Q50-Q56 Congenital malformations of genital organs
0.000 0.340 0.660
I47.0 Reentry ventricular arrhythmia
0.000 0.341 0.659
Q61.3 Polycystic kidney, unspecified
0.000 0.343 0.657
K55.2 Angiodysplasia of colon
0.000 0.344 0.656
H27.8 Other specified disorders of lens
0.000 0.344 0.656
G81.9 Hemiplegia, unspecified
0.654 0.346 0.000
K60.0 Acute anal fissure
0.000 0.348 0.652
I11 Hypertensive heart disease
0.000 0.348 0.652
K82.3 Fistula of gallbladder
0.000 0.349 0.651
E78.4 Other hyperlipidaemia
0.000 0.352 0.648
M46 Other inflammatory spondylopathies
0.000 0.352 0.648
I30 Acute pericarditis
0.000 0.352 0.648
M12 Other specific arthropathies
0.000 0.353 0.647
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.353 0.647
M14 Arthropathies in other diseases classified elsewhere
0.000 0.353 0.646
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.354 0.646
K82.9 Disease of gallbladder, unspecified
0.000 0.354 0.646
G40-G47 Episodic and paroxysmal disorders
0.645 0.355 0.000
I51.0 Cardiac septal defect, acquired
0.000 0.355 0.645
I52 Other heart disorders in diseases classified elsewhere
0.000 0.355 0.645
I48 Atrial fibrillation and flutter
0.000 0.355 0.645
I41 Myocarditis in diseases classified elsewhere
0.000 0.355 0.645
I40 Acute myocarditis
0.000 0.355 0.645
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.000 0.355 0.645
I32 Pericarditis in diseases classified elsewhere
0.000 0.355 0.645
E89.3 Postprocedural hypopituitarism
0.000 0.357 0.643
I24.1 Dressler's syndrome
0.000 0.360 0.640
H61.1 Non-infective disorders of pinna
0.000 0.363 0.637
E13.8 With unspecified complications
0.000 0.363 0.637
E13.7 With multiple complications
0.000 0.363 0.637
E13.6 With other specified complications
0.000 0.363 0.637
E13.5 With peripheral circulatory complications
0.000 0.363 0.637
E13.4 With neurological complications
0.000 0.363 0.637
E13.3 With ophthalmic complications
0.000 0.363 0.637
E13.2 With renal complications
0.000 0.363 0.637
E13.1 With ketoacidosis
0.000 0.363 0.637
E13.0 With coma
0.000 0.363 0.637
E83.3 Disorders of phosphorus metabolism
0.612 0.363 0.024
K73.9 Chronic hepatitis, unspecified
0.000 0.364 0.636
K60.5 Anorectal fistula
0.000 0.364 0.636
K51.0 Ulcerative (chronic) enterocolitis
0.635 0.364 0.000
E89.2 Postprocedural hypoparathyroidism
0.000 0.366 0.634
H60 Otitis externa
0.000 0.366 0.634
Q61.2 Polycystic kidney, adult type
0.000 0.367 0.633
K80.8 Other cholelithiasis
0.000 0.368 0.632
H27.0 Aphakia
0.000 0.368 0.632
E80.4 Gilbert's syndrome
0.000 0.369 0.631
H66 Suppurative and unspecified otitis media
0.000 0.371 0.628
M07.6 Other enteropathic arthropathies
0.000 0.372 0.628
M07.5 Arthropathy in ulcerative colitis
0.000 0.372 0.628
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.372 0.628
M07.2 Psoriatic spondylitis
0.000 0.372 0.628
M07.1 Arthritis mutilans
0.000 0.372 0.628
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.372 0.628
H46-H48 Disorders of optic nerve and visual pathways
0.000 0.375 0.625
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.375 0.624
K90.8 Other intestinal malabsorption
0.000 0.376 0.624
K51.1 Ulcerative (chronic) ileocolitis
0.623 0.377 0.001
K80.3 Calculus of bile duct with cholangitis
0.000 0.377 0.623
H53 Visual disturbances
0.000 0.380 0.620
I22.8 Subsequent myocardial infarction of other sites
0.000 0.380 0.620
K65-K67 Diseases of peritoneum
0.000 0.381 0.619
G83.4 Cauda equina syndrome
0.619 0.381 0.000
M49 Spondylopathies in diseases classified elsewhere
0.000 0.381 0.618
H43.1 Vitreous haemorrhage
0.000 0.382 0.617
H66.3 Other chronic suppurative otitis media
0.000 0.383 0.617
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.000 0.383 0.617
K90.9 Intestinal malabsorption, unspecified
0.000 0.385 0.615
H74 Other disorders of middle ear and mastoid
0.000 0.386 0.614
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.387 0.613
M06.38 Rheumatoid nodule (Other)
0.000 0.387 0.613
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.387 0.613
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.387 0.613
M06.33 Rheumatoid nodule (Forearm)
0.000 0.387 0.613
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.387 0.613
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.387 0.613
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.387 0.613
E05.5 Thyroid crisis or storm
0.000 0.388 0.612
E05.4 Thyrotoxicosis factitia
0.000 0.388 0.612
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.388 0.612
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.388 0.612
I15.9 Seconday hypertension, unspecified
0.000 0.388 0.612
I47.2 Ventricular tachycardia
0.000 0.389 0.611
K73.2 Chronic active hepatitis, not elsewhere classified
0.000 0.390 0.610
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.391 0.609
E83.9 Disorder of mineral metabolism, unspecified
0.557 0.398 0.045
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.399 0.601
K51.2 Ulcerative (chronic) proctitis
0.600 0.399 0.000
E06.5 Other chronic thyroiditis
0.000 0.401 0.598
E06.4 Drug-induced thyroiditis
0.000 0.401 0.598
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.401 0.598
E06.1 Subacute thyroiditis
0.000 0.401 0.598
E06.0 Acute thyroiditis
0.000 0.401 0.598
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.402 0.598
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.402 0.598
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.402 0.598
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.402 0.598
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.402 0.598
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.402 0.598
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.402 0.598
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.402 0.598
Q80-Q89 Other congenital malformations
0.000 0.402 0.597
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.403 0.597
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.403 0.597
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.403 0.597
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.403 0.597
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.403 0.597
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.403 0.597
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.403 0.597
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.403 0.597
G40 Epilepsy
0.596 0.404 0.000
J45 Asthma
0.000 0.405 0.595
I43 Cardiomyopathy in diseases classified elsewhere
0.000 0.406 0.593
E07.8 Other specified disorders of thyroid
0.000 0.407 0.593
I46.1 Sudden cardiac death, so described
0.000 0.407 0.593
I45 Other conduction disorders
0.000 0.407 0.593
K82.0 Obstruction of gallbladder
0.000 0.408 0.592
K55.8 Other vascular disorders of intestine
0.000 0.408 0.592
K75.0 Abscess of liver
0.000 0.409 0.591
G30 Alzheimer's disease
0.590 0.409 0.000
I15.8 Other secondary hypertension
0.000 0.409 0.590
I15.2 Hypertension secondary to endocrine disorders
0.000 0.409 0.590
I15.0 Renovascular hypertension
0.000 0.409 0.590
K72.1 Chronic hepatic failure
0.000 0.410 0.590
H61.0 Perichondritis of external ear
0.000 0.410 0.590
M11.2 Other chondrocalcinosis
0.000 0.410 0.590
L10-L14 Bullous disorders
0.000 0.411 0.589
G00-G09 Inflammatory diseases of the central nervous system
0.586 0.412 0.001
K58 Irritable bowel syndrome
0.000 0.413 0.587
I31.8 Other specified diseases of pericardium
0.000 0.414 0.586
I31.2 Haemopericardium, not elsewhere classified
0.000 0.414 0.586
I31.0 Chronic adhesive pericarditis
0.000 0.414 0.586
M10 Gout
0.000 0.415 0.584
K75.3 Granulomatous hepatitis, not elsewhere classified
0.000 0.417 0.583
K75.2 Nonspecific reactive hepatitis
0.000 0.417 0.583
K75.1 Phlebitis of portal vein
0.000 0.417 0.583
K81.8 Other cholecystitis
0.000 0.417 0.583
I23.8 Other current complications following acute myocardial infarction
0.000 0.417 0.583
E89.0 Postprocedural hypothyroidism
0.000 0.417 0.583
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.418 0.582
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.418 0.582
E89.5 Postprocedural testicular hypofunction
0.000 0.418 0.582
E89.1 Postprocedural hypoinsulinaemia
0.000 0.418 0.582
H35.8 Other specified retinal disorders
0.000 0.418 0.582
M70-M79 Other soft tissue disorders
0.000 0.418 0.582
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.424 0.576
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.424 0.576
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.424 0.576
E74.2 Disorders of galactose metabolism
0.000 0.424 0.576
E74.1 Disorders of fructose metabolism
0.000 0.424 0.576
E74.0 Glycogen storage disease
0.000 0.424 0.576
K50.8 Other Crohn's disease
0.001 0.425 0.574
M65 Synovitis and tenosynovitis
0.000 0.425 0.575
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.426 0.573
G44 Other headache syndromes
0.573 0.427 0.000
Q50 Congenital malformations of ovaries, Fallopian tubes and broad ligaments
0.000 0.427 0.573
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.428 0.571
H27.1 Dislocation of lens
0.000 0.429 0.571
H61.3 Acquired stenosis of external ear canal
0.000 0.430 0.570
E73 Lactose intolerance
0.000 0.430 0.569
E46 Unspecified protein-energy malnutrition
0.000 0.431 0.569
K75.9 Inflammatory liver disease, unspecified
0.000 0.434 0.566
M07.38 Other psoriatic arthropathies (Other)
0.000 0.434 0.565
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.434 0.565
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.434 0.565
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.434 0.565
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.434 0.565
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.434 0.565
K73.8 Other chronic hepatitis, not elsewhere classified
0.000 0.435 0.565

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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