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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3131631
log Bayes Factor = 79.9769
Chromosome 6   position 31,484,683  (GRCh37) Explore rs3131631 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
J45.9 Asthma, unspecified
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.001 0.999
E05.9 Thyrotoxicosis, unspecified
0.000 0.002 0.998
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.003 0.997
E10.4 With neurological complications
0.000 0.004 0.996
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.009 0.991
E10.1 With ketoacidosis
0.000 0.016 0.984
E14.3 With ophthalmic complications
0.000 0.018 0.982
E14.9 Without complications
0.000 0.020 0.980
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.032 0.968
L40 Psoriasis
0.947 0.053 0.000
I20.9 Angina pectoris, unspecified
0.000 0.058 0.942
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.059 0.941
I20-I25 Ischaemic heart diseases
0.000 0.060 0.940
I20 Angina pectoris
0.000 0.061 0.939
I22 Subsequent myocardial infarction
0.000 0.066 0.934
I25 Chronic ischaemic heart disease
0.000 0.078 0.922
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.082 0.918
E10.2 With renal complications
0.000 0.085 0.915
G35-G37 Demyelinating diseases of the central nervous system
0.914 0.086 0.000
E16 Other disorders of pancreatic internal secretion
0.000 0.099 0.901
L40.0 Psoriasis vulgaris
0.900 0.100 0.000
G37 Other demyelinating diseases of central nervous system
0.898 0.102 0.000
E83.1 Disorders of iron metabolism
0.896 0.104 0.000
M45 Ankylosing spondylitis
0.000 0.109 0.891
E13 Other specified diabetes mellitus
0.000 0.113 0.887
I25.5 Ischaemic cardiomyopathy
0.000 0.116 0.884
E07 Other disorders of thyroid
0.000 0.121 0.879
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.122 0.878
G37.9 Demyelinating disease of central nervous system, unspecified
0.870 0.130 0.000
L40.5 Arthropathic psoriasis
0.865 0.135 0.000
I25.1 Atherosclerotic heart disease
0.000 0.148 0.852
E10.5 With peripheral circulatory complications
0.000 0.149 0.851
E11 Non-insulin-dependent diabetes mellitus
0.000 0.167 0.833
E10.0 With coma
0.000 0.171 0.829
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.172 0.828
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.175 0.825
I24 Other acute ischaemic heart diseases
0.000 0.177 0.823
E07.9 Disorder of thyroid, unspecified
0.000 0.182 0.818
E16.2 Hypoglycaemia, unspecified
0.000 0.188 0.812
E11.9 Without complications
0.000 0.189 0.811
E13.9 Without complications
0.000 0.190 0.810
E14.8 With unspecified complications
0.000 0.198 0.802
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.198 0.802
I25.2 Old myocardial infarction
0.000 0.214 0.786
I20.1 Angina pectoris with documented spasm
0.000 0.214 0.786
E14.6 With other specified complications
0.000 0.229 0.771
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.231 0.769
I23 Certain current complications following acute myocardial infarction
0.000 0.233 0.767
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.235 0.765
G37.8 Other specified demyelinating diseases of central nervous system
0.758 0.242 0.000
E11.0 With coma
0.000 0.243 0.757
L40.1 Generalised pustular psoriasis
0.752 0.248 0.000
I25.3 Aneurysm of heart
0.000 0.252 0.748
E10.8 With unspecified complications
0.000 0.260 0.740
E14.1 With ketoacidosis
0.000 0.272 0.728
E14.5 With peripheral circulatory complications
0.000 0.274 0.725
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.284 0.716
E14.2 Withrenal complications
0.000 0.284 0.716
E14.0 With coma
0.000 0.284 0.716
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.716 0.284 0.000
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.286 0.714
E10.6 With other specified complications
0.000 0.289 0.711
E14.4 With neurological complications
0.000 0.291 0.709
E16.1 Other hypoglycaemia
0.000 0.309 0.691
E03.1 Congenital hypothyroidism without goitre
0.000 0.312 0.688
E06 Thyroiditis
0.000 0.320 0.680
L40.4 Guttate psoriasis
0.679 0.321 0.000
L40.2 Acrodermatitis continua
0.679 0.321 0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.321 0.679
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.322 0.678
E15 Nondiabetic hypoglycaemic coma
0.000 0.325 0.675
E05.8 Other thyrotoxicosis
0.000 0.328 0.672
L40.3 Pustulosis palmaris et plantaris
0.667 0.333 0.000
I25.6 Silent myocardial ischaemia
0.000 0.339 0.661
E11.6 With other specified complications
0.000 0.339 0.661
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.354 0.646
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.354 0.646
E16.4 Abnormal secretion of gastrin
0.000 0.354 0.646
E16.3 Increased secretion of glucagon
0.000 0.354 0.646
G37.5 Concentric sclerosis [Balo]
0.644 0.356 0.000
G37.4 Subacute necrotising myelitis
0.644 0.356 0.000
G37.2 Central pontine myelinolysis
0.644 0.356 0.000
G37.1 Central demyelination of corpus callosum
0.644 0.356 0.000
G37.0 Diffuse sclerosis
0.644 0.356 0.000
I23.8 Other current complications following acute myocardial infarction
0.000 0.357 0.643
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.361 0.639
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.361 0.639
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.361 0.639
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.361 0.639
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.361 0.639
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.361 0.639
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.361 0.639
E13.8 With unspecified complications
0.000 0.364 0.636
E13.7 With multiple complications
0.000 0.364 0.636
E13.6 With other specified complications
0.000 0.364 0.636
E13.5 With peripheral circulatory complications
0.000 0.364 0.636
E13.4 With neurological complications
0.000 0.364 0.636
E13.2 With renal complications
0.000 0.364 0.636
E13.1 With ketoacidosis
0.000 0.364 0.636
E13.0 With coma
0.000 0.364 0.636
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.364 0.635
G36 Other acute disseminated demyelination
0.631 0.369 0.000
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.370 0.630
E07.1 Dyshormogenetic goitre
0.000 0.370 0.630
E07.0 Hypersecretion of calcitonin
0.000 0.370 0.630
E13.3 With ophthalmic complications
0.000 0.374 0.626
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.382 0.618
I20.0 Unstable angina
0.000 0.390 0.610
L40.8 Other psoriasis
0.599 0.400 0.000
E11.7 With multiple complications
0.000 0.402 0.598
K90 Intestinal malabsorption
0.000 0.412 0.588
E40-E46 Malnutrition
0.000 0.422 0.578
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.450 0.550
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.450 0.550
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.450 0.550
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.450 0.550
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.450 0.550
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.450 0.550
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.450 0.550
I22.8 Subsequent myocardial infarction of other sites
0.000 0.471 0.529
I24.1 Dressler's syndrome
0.000 0.471 0.529
E06.9 Thyroiditis, unspecified
0.000 0.471 0.529
E07.8 Other specified disorders of thyroid
0.000 0.473 0.527
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
I25.4 Coronary artery aneurysm
0.000 0.487 0.513
E65-E68 Obesity and other hyperalimentation
0.000 0.488 0.512
E11.1 With ketoacidosis
0.000 0.492 0.508
E11.2 With renal complications
0.000 0.493 0.507
K90.9 Intestinal malabsorption, unspecified
0.000 0.497 0.503
E11.5 With peripheral circulatory complications
0.000 0.511 0.489
E06.5 Other chronic thyroiditis
0.000 0.512 0.487
E06.4 Drug-induced thyroiditis
0.000 0.512 0.487
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.512 0.487
E06.1 Subacute thyroiditis
0.000 0.512 0.487
E06.0 Acute thyroiditis
0.000 0.512 0.487
K90.8 Other intestinal malabsorption
0.000 0.538 0.462
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.541 0.458
G36.9 Acute disseminated demyelination, unspecified
0.453 0.547 0.000
G36.8 Other specified acute disseminated demyelination
0.453 0.547 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.453 0.547 0.000
E50-E64 Other nutritional deficiencies
0.000 0.548 0.452
E03.8 Other specified hypothyroidism
0.001 0.548 0.451
G36.0 Neuromyelitis optica [Devic]
0.429 0.571 0.000
E11.8 With unspecified complications
0.000 0.574 0.426
K90.3 Pancreatic steatorrhoea
0.000 0.578 0.422
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.578 0.422
K90.1 Tropical sprue
0.000 0.578 0.422
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.585 0.414
E45 Retarded development following protein-energy malnutrition
0.000 0.585 0.414
E43 Unspecified severe protein-energy malnutrition
0.000 0.585 0.414
E42 Marasmic kwashiorkor
0.000 0.585 0.414
E41 Nutritional marasmus
0.000 0.585 0.414
E40 Kwashiorkor
0.000 0.585 0.414
I24.8 Other forms of acute ischaemic heart disease
0.000 0.602 0.398
E06.3 Autoimmune thyroiditis
0.000 0.613 0.387
E65 Localised adiposity
0.000 0.618 0.382
E11.3 With ophthalmic complications
0.000 0.630 0.370
E67 Other hyperalimentation
0.000 0.632 0.367
E68 Sequelae of hyperalimentation
0.000 0.632 0.367
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.642 0.358
E61 Deficiency of other nutrient elements
0.000 0.658 0.342
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.676 0.324
E63 Other nutritional deficiencies
0.000 0.676 0.324
E51 Thiamine deficiency
0.000 0.676 0.324
E50 Vitamin A deficiency
0.000 0.676 0.324
E60 Dietary zinc deficiency
0.000 0.676 0.324
E59 Dietary selenium deficiency
0.000 0.676 0.324
E58 Dietary calcium deficiency
0.000 0.676 0.324
E54 Ascorbic acid deficiency
0.000 0.676 0.324
E52 Niacin deficiency [pellagra]
0.000 0.676 0.324
E56 Other vitamin deficiencies
0.000 0.684 0.316
I21 Acute myocardial infarction
0.000 0.696 0.304
E44.1 Mild protein-energy malnutrition
0.000 0.703 0.297
E44.0 Moderate protein-energy malnutrition
0.000 0.703 0.297
E46 Unspecified protein-energy malnutrition
0.000 0.722 0.277
E11.4 With neurological complications
0.000 0.727 0.272
E61.2 Magnesium deficiency
0.000 0.734 0.266
E67.8 Other specified hyperalimentation
0.000 0.736 0.263
E67.3 Hypervitaminosis D
0.000 0.736 0.263
E67.2 Megavitamin-B6 syndrome
0.000 0.736 0.263
E67.1 Hypercarotenaemia
0.000 0.736 0.263
E67.0 Hypervitaminosis A
0.000 0.736 0.263
E55 Vitamin D deficiency
0.000 0.737 0.263
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.737 0.263
E61.9 Deficiency of nutrient element, unspecified
0.000 0.754 0.246
E61.8 Deficiency of other specified nutrient elements
0.000 0.754 0.246
E61.7 Deficiency of multiple nutrient elements
0.000 0.754 0.246
E61.6 Vanadium deficiency
0.000 0.754 0.246
E61.5 Molybdenum deficiency
0.000 0.754 0.246
E61.4 Chromium deficiency
0.000 0.754 0.246
E61.3 Manganese deficiency
0.000 0.754 0.246
E61.0 Copper deficiency
0.000 0.754 0.246
E61.1 Iron deficiency
0.000 0.758 0.242
E50.9 Vitamin A deficiency, unspecified
0.000 0.767 0.232
E50.8 Other manifestations of vitamin A deficiency
0.000 0.767 0.232
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.767 0.232
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.767 0.232
E50.5 Vitamin A deficiency with night blindness
0.000 0.767 0.232
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.767 0.232
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.767 0.232
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.767 0.232
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.767 0.232
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.767 0.232
E51.9 Thiamine deficiency, unspecified
0.000 0.767 0.232
E51.8 Other manifestations of thiamine deficiency
0.000 0.767 0.232
E51.2 Wernicke's encephalopathy
0.000 0.767 0.232
E51.1 Beriberi
0.000 0.767 0.232
E63.9 Nutritional deficiency, unspecified
0.000 0.767 0.232
E63.8 Other specified nutritional deficiencies
0.000 0.767 0.232
E63.1 Imbalance of constituents of food intake
0.000 0.767 0.232
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.767 0.232
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.767 0.232
E64.8 Sequelae of other nutritional deficiencies
0.000 0.767 0.232
E64.3 Sequelae of rickets
0.000 0.767 0.232
E64.2 Sequelae of vitamin C deficiency
0.000 0.767 0.232
E64.1 Sequelae of vitamin A deficiency
0.000 0.767 0.232
E64.0 Sequelae of protein-energy malnutrition
0.000 0.767 0.232
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.770 0.230
E56.9 Vitamin deficiency, unspecified
0.000 0.773 0.226
E56.8 Deficiency of other vitamins
0.000 0.773 0.226
E56.0 Deficiency of vitamin E
0.000 0.773 0.226
L40-L45 Papulosquamous disorders
0.217 0.776 0.008
E56.1 Deficiency of vitamin K
0.000 0.782 0.218
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.782 0.218
I21.9 Acute myocardial infarction, unspecified
0.000 0.806 0.194
E55.0 Rickets, active
0.000 0.811 0.189
J45 Asthma
0.000 0.819 0.180
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.820 0.179
L44 Other papulosquamous disorders
0.163 0.832 0.005
E53 Deficiency of other B group vitamins
0.000 0.837 0.163
L41 Parapsoriasis
0.155 0.839 0.006
L45 Papulosquamous disorders in diseases classified elsewhere
0.155 0.839 0.006
L42 Pityriasis rosea
0.150 0.845 0.005
E83 Disorders of mineral metabolism
0.128 0.849 0.023
J45.1 Nonallergic asthma
0.000 0.870 0.129
L44.0 Pityriasis rubra pilaris
0.125 0.872 0.003
E55.9 Vitamin D deficiency, unspecified
0.000 0.872 0.127
E66 Obesity
0.000 0.874 0.126
J45.8 Mixed asthma
0.000 0.876 0.123
I20.8 Other forms of angina pectoris
0.000 0.878 0.122
L44.9 Papulosquamous disorder, unspecified
0.117 0.879 0.004
L44.8 Other specified papulosquamous disorders
0.117 0.879 0.004
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.117 0.879 0.004
L44.3 Lichen ruber moniliformis
0.117 0.879 0.004
L44.2 Lichen striatus
0.117 0.879 0.004
L44.1 Lichen nitidus
0.117 0.879 0.004
E20-E35 Disorders of other endocrine glands
0.000 0.879 0.121
E53.1 Pyridoxine deficiency
0.000 0.883 0.117
E53.0 Riboflavin deficiency
0.000 0.883 0.117
L41.9 Parapsoriasis, unspecified
0.112 0.884 0.004
L41.8 Other parapsoriasis
0.112 0.884 0.004
L41.5 Retiform parapsoriasis
0.112 0.884 0.004
L41.4 Large plaque parapsoriasis
0.112 0.884 0.004
L41.3 Small plaque parapsoriasis
0.112 0.884 0.004
L41.2 Lymphomatoid papulosis
0.112 0.884 0.004
L41.1 Pityriasis lichenoides chronica
0.112 0.884 0.004
L41.0 Pityriasis lichenoides et varioliformis acuta
0.112 0.884 0.004
E83.3 Disorders of phosphorus metabolism
0.108 0.885 0.007
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.889 0.111
E83.9 Disorder of mineral metabolism, unspecified
0.092 0.892 0.016
E83.8 Other disorders of mineral metabolism
0.092 0.892 0.016
E83.2 Disorders of zinc metabolism
0.092 0.892 0.016
E83.0 Disorders of copper metabolism
0.092 0.892 0.016
E66.0 Obesity due to excess calories
0.000 0.899 0.100
E22 Hyperfunction of pituitary gland
0.000 0.900 0.100
E04 Other non-toxic goitre
0.000 0.900 0.100
E29 Testicular dysfunction
0.000 0.903 0.097
E53.9 Vitamin B deficiency, unspecified
0.000 0.906 0.094
E66.1 Drug-induced obesity
0.000 0.910 0.090
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.912 0.088
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.913 0.087
E32 Diseases of thymus
0.000 0.913 0.087
E31 Polyglandular dysfunction
0.000 0.913 0.087
E30 Disorders of puberty, not elsewhere classified
0.000 0.913 0.087
L43 Lichen planus
0.053 0.914 0.032
E22.1 Hyperprolactinaemia
0.000 0.916 0.083
E23 Hypofunction and other disorders of pituitary gland
0.000 0.917 0.083
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.917 0.083
I21.4 Acute subendocardial myocardial infarction
0.000 0.919 0.081
E20 Hypoparathyroidism
0.000 0.920 0.080
E29.1 Testicular hypofunction
0.000 0.920 0.080
E24 Cushing's syndrome
0.000 0.923 0.077
E26 Hyperaldosteronism
0.000 0.923 0.076
E28 Ovarian dysfunction
0.000 0.925 0.075
E23.2 Diabetes insipidus
0.000 0.926 0.074
E25 Adrenogenital disorders
0.000 0.927 0.073
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.927 0.073
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.928 0.072
E22.8 Other hyperfunction of pituitary gland
0.000 0.928 0.072
E04.8 Other specified non-toxic goitre
0.000 0.928 0.072
E29.9 Testicular dysfunction, unspecified
0.000 0.930 0.069
E29.8 Other testicular dysfunction
0.000 0.930 0.069
E29.0 Testicular hyperfunction
0.000 0.930 0.069
E70-E90 Metabolic disorders
0.003 0.933 0.064
E23.6 Other disorders of pituitary gland
0.000 0.935 0.065
E30.9 Disorder of puberty, unspecified
0.000 0.937 0.062
E30.8 Other disorders of puberty
0.000 0.937 0.062
E30.1 Precocious puberty
0.000 0.937 0.062
E30.0 Delayed puberty
0.000 0.937 0.062
E31.9 Polyglandular dysfunction, unspecified
0.000 0.937 0.062
E31.8 Other polyglandular dysfunction
0.000 0.937 0.062
E31.1 Polyglandular hyperfunction
0.000 0.937 0.062
E31.0 Autoimmune polyglandular failure
0.000 0.937 0.062
E32.9 Disease of thymus, unspecified
0.000 0.937 0.062
E32.8 Other diseases of thymus
0.000 0.937 0.062
E32.1 Abscess of thymus
0.000 0.937 0.062
E32.0 Persistent hyperplasia of thymus
0.000 0.937 0.062
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.937 0.062
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.937 0.062
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.937 0.062
E22.0 Acromegaly and pituitary gigantism
0.000 0.938 0.062
L43.3 Subacute (active) lichen planus
0.038 0.938 0.023
L43.2 Lichenoid drug reaction
0.038 0.938 0.023
L43.1 Bullous lichen planus
0.038 0.938 0.023
L43.0 Hypertrophic lichen planus
0.038 0.938 0.023
E34 Other endocrine disorders
0.001 0.939 0.060
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.940 0.060
E23.1 Drug-induced hypopituitarism
0.000 0.940 0.060
E20.8 Other hypoparathyroidism
0.000 0.942 0.057
E20.1 Pseudohypoparathyroidism
0.000 0.942 0.057
E20.0 Idiopathic hypoparathyroidism
0.000 0.942 0.057
E28.3 Primary ovarian failure
0.000 0.944 0.056
E85 Amyloidosis
0.001 0.944 0.054
E24.8 Other Cushing's syndrome
0.000 0.944 0.055
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.944 0.055
E24.3 Ectopic ACTH syndrome
0.000 0.944 0.055
E24.2 Drug-induced Cushing's syndrome
0.000 0.944 0.055
E24.1 Nelson's syndrome
0.000 0.944 0.055
E26.9 Hyperaldosteronism, unspecified
0.000 0.945 0.055
E26.8 Other hyperaldosteronism
0.000 0.945 0.055
E26.1 Secondary hyperaldosteronism
0.000 0.945 0.055
E24.0 Pituitary-dependent Cushing's disease
0.000 0.945 0.054
E28.9 Ovarian dysfunction, unspecified
0.000 0.946 0.054
E28.8 Other ovarian dysfunction
0.000 0.946 0.054
E28.1 Androgen excess
0.000 0.946 0.054
E28.0 Oestrogen excess
0.000 0.946 0.054
E25.9 Adrenogenital disorder, unspecified
0.000 0.947 0.052
E25.8 Other adrenogenital disorders
0.000 0.947 0.052
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.949 0.051
E20.9 Hypoparathyroidism, unspecified
0.000 0.949 0.050
L43.8 Other lichen planus
0.020 0.950 0.030
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.001 0.950 0.050
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.950 0.050
E79 Disorders of purine and pyrimidine metabolism
0.002 0.951 0.047
E04.0 Non-toxic diffuse goitre
0.000 0.951 0.049
E23.7 Disorder of pituitary gland, unspecified
0.000 0.952 0.048
E77 Disorders of glycoprotein metabolism
0.002 0.952 0.046
E76 Disorders of glycosaminoglycan metabolism
0.002 0.952 0.046
E72 Other disorders of amino-acid metabolism
0.002 0.952 0.046
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.002 0.952 0.046
E70 Disorders of aromatic amino-acid metabolism
0.002 0.952 0.046
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.002 0.952 0.046
E85.9 Amyloidosis, unspecified
0.001 0.952 0.047
E74 Other disorders of carbohydrate metabolism
0.002 0.953 0.045
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.002 0.953 0.044
E24.9 Cushing's syndrome, unspecified
0.000 0.953 0.046
E78.0 Pure hypercholesterolaemia
0.000 0.953 0.047
E73 Lactose intolerance
0.002 0.955 0.043
E26.0 Primary hyperaldosteronism
0.000 0.955 0.045
E34.8 Other specified endocrine disorders
0.000 0.955 0.045
E84 Cystic fibrosis
0.002 0.955 0.043
E04.9 Non-toxic goitre, unspecified
0.000 0.956 0.044
E89.3 Postprocedural hypopituitarism
0.000 0.956 0.044
E34.5 Androgen resistance syndrome
0.001 0.956 0.043
E34.4 Constitutional tall stature
0.001 0.956 0.043
E34.3 Short stature, not elsewhere classified
0.001 0.956 0.043
E34.2 Ectopic hormone secretion, not elsewhere classified
0.001 0.956 0.043
E34.1 Other hypersecretion of intestinal hormones
0.001 0.956 0.043
L43.9 Lichen planus, unspecified
0.002 0.957 0.041
M75.0 Adhesive capsulitis of shoulder
0.000 0.958 0.042
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.958 0.041
E85.3 Secondary systemic amyloidosis
0.001 0.959 0.040
E78.8 Other disorders of lipoprotein metabolism
0.000 0.960 0.040
E85.8 Other amyloidosis
0.001 0.960 0.039
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.960 0.039
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.960 0.039
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.960 0.039
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.960 0.040
E78.1 Pure hyperglyceridaemia
0.000 0.960 0.039
E34.0 Carcinoid syndrome
0.001 0.960 0.039
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.001 0.961 0.039
M45-M49 Spondylopathies
0.000 0.961 0.039
E83.4 Disorders of magnesium metabolism
0.019 0.961 0.020
E04.1 Non-toxic single thyroid nodule
0.000 0.961 0.039
E28.2 Polycystic ovarian syndrome
0.000 0.961 0.039
E85.4 Organ-limited amyloidosis
0.001 0.961 0.038
K90-K93 Other diseases of the digestive system
0.000 0.962 0.038
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.963 0.037
E21.4 Other specified disorders of parathyroid gland
0.000 0.963 0.037
E21.2 Other hyperparathyroidism
0.000 0.963 0.037
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.001 0.964 0.035
E74.3 Other disorders of intestinal carbohydrate absorption
0.001 0.964 0.035
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.001 0.964 0.036
E89.8 Other postprocedural endocrine and metabolic disorders
0.001 0.964 0.036
E89.5 Postprocedural testicular hypofunction
0.001 0.964 0.036
E89.1 Postprocedural hypoinsulinaemia
0.001 0.964 0.036
E78.3 Hyperchylomicronaemia
0.000 0.964 0.036
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.002 0.965 0.034
E79.8 Other disorders of purine and pyrimidine metabolism
0.002 0.965 0.034
E79.1 Lesch-Nyhan syndrome
0.002 0.965 0.034
E78.6 Lipoprotein deficiency
0.000 0.965 0.035
E80 Disorders of porphyrin and bilirubin metabolism
0.002 0.965 0.033
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.002 0.965 0.033
E70.8 Other disorders of aromatic amino-acid metabolism
0.002 0.965 0.033
E70.3 Albinism
0.002 0.965 0.033
E70.2 Disorders of tyrosine metabolism
0.002 0.965 0.033
E70.1 Other hyperphenylalaninaemias
0.002 0.965 0.033
E70.0 Classical phenylketonuria
0.002 0.965 0.033
E71.3 Disorders of fatty-acid metabolism
0.002 0.965 0.033
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.002 0.965 0.033
E71.1 Other disorders of branched-chain amino-acid metabolism
0.002 0.965 0.033
E71.0 Maple-syrup-urine disease
0.002 0.965 0.033
E72.9 Disorder of amino-acid metabolism, unspecified
0.002 0.965 0.033
E72.8 Other specified disorders of amino-acid metabolism
0.002 0.965 0.033
E72.5 Disorders of glycine metabolism
0.002 0.965 0.033
E72.4 Disorders of ornithine metabolism
0.002 0.965 0.033
E72.3 Disorders of lysine and hydroxylysine metabolism
0.002 0.965 0.033
E72.2 Disorders of urea cycle metabolism
0.002 0.965 0.033
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.002 0.965 0.033
E72.0 Disorders of amino-acid transport
0.002 0.965 0.033
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.002 0.965 0.033
E76.8 Other disorders of glucosaminoglycan metabolism
0.002 0.965 0.033
E76.3 Mucopolysaccharidosis, unspecified
0.002 0.965 0.033
E76.2 Other mucopolysaccharidoses
0.002 0.965 0.033
E76.1 Mucopolysaccharidosis, type II
0.002 0.965 0.033
E76.0 Mucopolysaccharidosis, type I
0.002 0.965 0.033
E77.9 Disorder of glycoprotein metabolism, unspecified
0.002 0.965 0.033
E77.8 Other disorders of glycoprotein metabolism
0.002 0.965 0.033
E77.1 Defects in glycoprotein degradation
0.002 0.965 0.033
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.002 0.965 0.033
E78.2 Mixed hyperlipidaemia
0.000 0.965 0.035
E74.9 Disorder of carbohydrate metabolism, unspecified
0.002 0.966 0.033
E74.8 Other specified disorders of carbohydrate metabolism
0.002 0.966 0.033
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.002 0.966 0.033
E74.2 Disorders of galactose metabolism
0.002 0.966 0.033
E74.1 Disorders of fructose metabolism
0.002 0.966 0.033
E83.5 Disorders of calcium metabolism
0.029 0.966 0.005
E75.6 Lipid storage disorder, unspecified
0.002 0.966 0.032
E75.4 Neuronal ceroid lipofuscinosis
0.002 0.966 0.032
E75.3 Sphingolipidosis, unspecified
0.002 0.966 0.032
E75.2 Other sphingolipidosis
0.002 0.966 0.032
E75.1 Other gangliosidosis
0.002 0.966 0.032
E75.0 GM2 gangliosidosis
0.002 0.966 0.032
E73.8 Other lactose intolerance
0.002 0.967 0.031
E73.1 Secondary lactase deficiency
0.002 0.967 0.031
E73.0 Congenital lactase deficiency
0.002 0.967 0.031
E89.2 Postprocedural hypoparathyroidism
0.000 0.967 0.032
E84.8 Cystic fibrosis with other manifestations
0.002 0.967 0.031
E84.1 Cystic fibrosis with intestinal manifestations
0.002 0.967 0.031
E84.0 Cystic fibrosis with pulmonary manifestations
0.002 0.967 0.031
E75.5 Other lipid storage disorders
0.002 0.968 0.031
E78.4 Other hyperlipidaemia
0.000 0.968 0.032
H36.0 Diabetic retinopathy
0.000 0.969 0.031
E74.0 Glycogen storage disease
0.002 0.969 0.029
E89.4 Postprocedural ovarian failure
0.001 0.969 0.030
E73.9 Lactose intolerance, unspecified
0.001 0.970 0.029
E84.9 Cystic fibrosis, unspecified
0.002 0.971 0.027
E88 Other metabolic disorders
0.003 0.971 0.026
M49 Spondylopathies in diseases classified elsewhere
0.000 0.971 0.029
J45.0 Predominantly allergic asthma
0.000 0.972 0.028

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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