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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3134931
log Bayes Factor = 38.6873
Chromosome 6   position 32,190,620  (GRCh37) Explore rs3134931 on Ensembl!
Variant rs3134931 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.001 0.999
E20-E35 Disorders of other endocrine glands
0.000 0.001 0.999
E03 Other hypothyroidism
0.000 0.002 0.998
E03.9 Hypothyroidism, unspecified
0.000 0.002 0.998
E10.1 With ketoacidosis
0.000 0.003 0.997
E27 Other disorders of adrenal gland
0.000 0.003 0.997
E27.1 Primary adrenocortical insufficiency
0.000 0.006 0.994
E11 Non-insulin-dependent diabetes mellitus
0.000 0.009 0.991
E11.3 With ophthalmic complications
0.000 0.013 0.987
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.014 0.986
E21.3 Hyperparathyroidism, unspecified
0.000 0.030 0.970
E04 Other non-toxic goitre
0.000 0.046 0.954
D86.9 Sarcoidosis, unspecified
0.000 0.049 0.951
D86 Sarcoidosis
0.000 0.050 0.950
E10.2 With renal complications
0.000 0.053 0.947
E11.1 With ketoacidosis
0.000 0.054 0.946
E04.9 Non-toxic goitre, unspecified
0.000 0.066 0.934
E10.4 With neurological complications
0.000 0.083 0.917
E11.2 With renal complications
0.000 0.086 0.914
E21.0 Primary hyperparathyroidism
0.000 0.096 0.904
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
0.902 0.098 0.000
D80-D89 Certain disorders involving the immune mechanism
0.000 0.104 0.896
D86.0 Sarcoidosis of lung
0.000 0.107 0.893
E10.5 With peripheral circulatory complications
0.000 0.107 0.893
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.111 0.889
D50-D53 Nutritional anaemias
0.000 0.119 0.881
K90 Intestinal malabsorption
0.000 0.125 0.875
E10.0 With coma
0.000 0.126 0.874
E34 Other endocrine disorders
0.000 0.135 0.865
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.135 0.865
E10.6 With other specified complications
0.000 0.150 0.850
D86.3 Sarcoidosis of skin
0.000 0.151 0.849
D86.1 Sarcoidosis of lymph nodes
0.000 0.154 0.846
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.157 0.843
D52 Folate deficiency anaemia
0.000 0.159 0.841
E27.8 Other specified disorders of adrenal gland
0.000 0.165 0.835
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.180 0.820
D52.9 Folate deficiency anaemia, unspecified
0.000 0.187 0.813
E05.8 Other thyrotoxicosis
0.000 0.190 0.810
K90.9 Intestinal malabsorption, unspecified
0.000 0.198 0.802
E27.2 Addisonian crisis
0.000 0.198 0.802
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.795 0.205 0.000
D50 Iron deficiency anaemia
0.000 0.211 0.789
E27.9 Disorder of adrenal gland, unspecified
0.000 0.212 0.788
E14 Unspecified diabetes mellitus
0.000 0.213 0.787
E07 Other disorders of thyroid
0.000 0.215 0.785
D50.9 Iron deficiency anaemia, unspecified
0.000 0.220 0.780
D51 Vitamin B12 deficiency anaemia
0.000 0.221 0.779
H36.0 Diabetic retinopathy
0.000 0.224 0.776
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.225 0.775
E04.0 Non-toxic diffuse goitre
0.000 0.227 0.773
H36 Retinal disorders in diseases classified elsewhere
0.000 0.233 0.767
Chapter VI Diseases of the nervous system
0.000 0.234 0.766
E11.8 With unspecified complications
0.000 0.235 0.765
# Top node
0.000 0.237 0.763
E34.0 Carcinoid syndrome
0.000 0.238 0.762
H30-H36 Disorders of choroid and retina
0.000 0.239 0.761
Chapter VII Diseases of the eye and adnexa
0.000 0.239 0.761
E20 Hypoparathyroidism
0.000 0.239 0.760
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.000 0.242 0.758
H02 Other disorders of eyelid
0.000 0.242 0.758
H02.3 Blepharochalasis
0.000 0.253 0.747
E10.8 With unspecified complications
0.000 0.258 0.742
E40-E46 Malnutrition
0.000 0.262 0.738
H02.1 Ectropion of eyelid
0.000 0.264 0.736
E16 Other disorders of pancreatic internal secretion
0.000 0.269 0.731
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.273 0.727
D69 Purpura and other haemorrhagic conditions
0.000 0.275 0.725
C82.0 Small cleaved cell, follicular
0.724 0.276 0.000
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.283 0.716
E32 Diseases of thymus
0.000 0.283 0.716
E31 Polyglandular dysfunction
0.000 0.283 0.716
E30 Disorders of puberty, not elsewhere classified
0.000 0.283 0.716
E03.5 Myxoedema coma
0.000 0.284 0.715
E03.4 Atrophy of thyroid (acquired)
0.000 0.284 0.715
E03.3 Postinfectious hypothyroidism
0.000 0.284 0.715
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.284 0.715
E27.5 Adrenomedullary hyperfunction
0.000 0.285 0.715
E27.0 Other adrenocortical overactivity
0.000 0.285 0.715
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.285 0.714
D86.8 Sarcoidosis of other and combined sites
0.000 0.288 0.712
E11.7 With multiple complications
0.000 0.289 0.711
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.290 0.710
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.000 0.290 0.709
G90-G99 Other disorders of the nervous system
0.000 0.295 0.705
E07.8 Other specified disorders of thyroid
0.000 0.298 0.702
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.304 0.696
E14.3 With ophthalmic complications
0.000 0.310 0.690
E34.8 Other specified endocrine disorders
0.000 0.314 0.686
E04.8 Other specified non-toxic goitre
0.000 0.316 0.684
E06 Thyroiditis
0.000 0.320 0.680
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.325 0.675
H06.2 Dysthyroid exophthalmos
0.000 0.325 0.675
E21.2 Other hyperparathyroidism
0.000 0.326 0.674
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.000 0.326 0.674
K50.9 Crohn's disease, unspecified
0.665 0.335 0.000
E23 Hypofunction and other disorders of pituitary gland
0.000 0.340 0.660
C82.7 Other types of follicular non-Hodgkin's lymphoma
0.658 0.342 0.000
H02.0 Entropion and trichiasis of eyelid
0.000 0.343 0.657
E16.2 Hypoglycaemia, unspecified
0.000 0.345 0.655
G80-G83 Cerebral palsy and other paralytic syndromes
0.000 0.348 0.652
K50 Crohn's disease [regional enteritis]
0.651 0.348 0.001
D69.4 Other primary thrombocytopenia
0.000 0.350 0.650
K90-K93 Other diseases of the digestive system
0.000 0.351 0.649
E28 Ovarian dysfunction
0.000 0.352 0.648
H43-H45 Disorders of vitreous body and globe
0.000 0.353 0.647
E29 Testicular dysfunction
0.000 0.354 0.645
K75.4 Autoimmune hepatitis
0.000 0.356 0.644
D81 Combined immunodeficiencies
0.000 0.358 0.642
D69.6 Thrombocytopenia, unspecified
0.000 0.358 0.642
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.358 0.641
H35 Other retinal disorders
0.000 0.360 0.640
H16 Keratitis
0.000 0.361 0.639
E03.1 Congenital hypothyroidism without goitre
0.000 0.362 0.638
K75 Other inflammatory liver diseases
0.000 0.362 0.638
G36 Other acute disseminated demyelination
0.000 0.363 0.637
K50.1 Crohn's disease of large intestine
0.636 0.364 0.000
C82.1 Mixed small cleaved and large cell, follicular
0.636 0.364 0.000
H02.4 Ptosis of eyelid
0.000 0.365 0.635
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.365 0.635
D55-D59 Haemolytic anaemias
0.000 0.366 0.634
Chapter XI Diseases of the digestive system
0.000 0.367 0.633
K70-K77 Diseases of liver
0.000 0.371 0.629
C82.4 Follicular lymphoma grade IIIb
0.629 0.371 0.000
E14.1 With ketoacidosis
0.000 0.372 0.628
E50-E64 Other nutritional deficiencies
0.000 0.372 0.628
K90.3 Pancreatic steatorrhoea
0.000 0.373 0.627
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.373 0.627
K90.1 Tropical sprue
0.000 0.373 0.627
H05 Disorders of orbit
0.000 0.373 0.627
D53 Other nutritional anaemias
0.000 0.376 0.624
D82 Immunodeficiency associated with other major defects
0.000 0.377 0.623
G98 Other disorders of nervous system, not elsewhere classified
0.000 0.378 0.622
E34.5 Androgen resistance syndrome
0.000 0.379 0.620
E34.4 Constitutional tall stature
0.000 0.379 0.620
E34.3 Short stature, not elsewhere classified
0.000 0.379 0.620
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.379 0.620
E34.1 Other hypersecretion of intestinal hormones
0.000 0.379 0.620
G81 Hemiplegia
0.000 0.381 0.619
E11.6 With other specified complications
0.000 0.382 0.618
G90 Disorders of autonomic nervous system
0.000 0.388 0.612
H30 Chorioretinal inflammation
0.000 0.390 0.609
G37 Other demyelinating diseases of central nervous system
0.000 0.394 0.605
H02.5 Other disorders affecting eyelid function
0.000 0.395 0.605
K50.0 Crohn's disease of small intestine
0.605 0.395 0.000
E15 Nondiabetic hypoglycaemic coma
0.000 0.395 0.605
E26 Hyperaldosteronism
0.000 0.396 0.604
G91 Hydrocephalus
0.000 0.396 0.604
C82.3 Follicular lymphoma grade IIIa
0.604 0.396 0.000
D52.8 Other folate deficiency anaemias
0.000 0.397 0.603
D52.1 Drug-induced folate deficiency anaemia
0.000 0.397 0.603
D52.0 Dietary folate deficiency anaemia
0.000 0.397 0.603
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.401 0.599
H31 Other disorders of choroid
0.000 0.401 0.599
E14.8 With unspecified complications
0.000 0.401 0.599
E04.2 Non-toxic multinodular goitre
0.000 0.403 0.597
E14.4 With neurological complications
0.000 0.405 0.595
E24 Cushing's syndrome
0.000 0.406 0.594
E14.5 With peripheral circulatory complications
0.000 0.409 0.591
E20.9 Hypoparathyroidism, unspecified
0.000 0.411 0.589
H00 Hordeolum and chalazion
0.000 0.414 0.586
H35.8 Other specified retinal disorders
0.000 0.416 0.584
G93 Other disorders of brain
0.000 0.418 0.582
G81.9 Hemiplegia, unspecified
0.000 0.420 0.580
H16.0 Corneal ulcer
0.000 0.420 0.580
D69.0 Allergic purpura
0.000 0.422 0.578
K75.8 Other specified inflammatory liver diseases
0.000 0.423 0.577
D60-D64 Aplastic and other anaemias
0.000 0.427 0.573
E06.3 Autoimmune thyroiditis
0.000 0.427 0.573
C82.6 Cutaneous follicle centre lymphoma
0.570 0.430 0.000
C82.5 Diffuse follicle centre lymphoma
0.570 0.430 0.000
G70-G73 Diseases of myoneural junction and muscle
0.000 0.430 0.570
D50.1 Sideropenic dysphagia
0.000 0.434 0.565
E14.7 With multiple complications
0.000 0.436 0.564
E14.0 With coma
0.000 0.436 0.564
E07.1 Dyshormogenetic goitre
0.000 0.437 0.563
E07.0 Hypersecretion of calcitonin
0.000 0.437 0.563
H35.4 Peripheral retinal degeneration
0.000 0.438 0.562
H35.3 Degeneration of macula and posterior pole
0.000 0.439 0.561
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.439 0.561
D84 Other immunodeficiencies
0.000 0.440 0.560
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.441 0.559
D51.2 Transcobalamin II deficiency
0.000 0.441 0.559
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.441 0.559
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.442 0.558
H43 Disorders of vitreous body
0.000 0.442 0.558
G90.9 Disorder of autonomic nervous system, unspecified
0.000 0.442 0.558
H15 Disorders of sclera
0.000 0.444 0.556
H19 Disorders of sclera and cornea in diseases classified elsewhere
0.000 0.444 0.556
H35.2 Other proliferative retinopathy
0.000 0.445 0.555
E34.9 Endocrine disorder, unspecified
0.000 0.446 0.554
G93.9 Disorder of brain, unspecified
0.000 0.448 0.552
H00.0 Hordeolum and other deep inflammation of eyelid
0.000 0.449 0.551
E46 Unspecified protein-energy malnutrition
0.000 0.450 0.550
K74 Fibrosis and cirrhosis of liver
0.000 0.450 0.550
G83 Other paralytic syndromes
0.000 0.450 0.550
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.450 0.550
H43.1 Vitreous haemorrhage
0.000 0.452 0.548
C82.2 Large cell, follicular
0.548 0.452 0.000
E21.4 Other specified disorders of parathyroid gland
0.000 0.452 0.547
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.454 0.546
E20.8 Other hypoparathyroidism
0.000 0.455 0.545
E20.1 Pseudohypoparathyroidism
0.000 0.455 0.545
E20.0 Idiopathic hypoparathyroidism
0.000 0.455 0.545
E14.2 Withrenal complications
0.000 0.455 0.545
I60-I69 Cerebrovascular diseases
0.000 0.456 0.544
H02.7 Other degenerative disorders of eyelid and periocular area
0.000 0.456 0.543
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.460 0.540
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.000 0.462 0.537
E25 Adrenogenital disorders
0.001 0.463 0.536
K90.8 Other intestinal malabsorption
0.000 0.467 0.533
D69.5 Secondary thrombocytopenia
0.000 0.467 0.533
I63 Cerebral infarction
0.000 0.468 0.532
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.468 0.531
D68 Other coagulation defects
0.000 0.469 0.531
D83 Common variable immunodeficiency
0.000 0.469 0.531
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.469 0.531
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.471 0.529
E45 Retarded development following protein-energy malnutrition
0.000 0.471 0.529
E43 Unspecified severe protein-energy malnutrition
0.000 0.471 0.529
E42 Marasmic kwashiorkor
0.000 0.471 0.529
E41 Nutritional marasmus
0.000 0.471 0.529
E40 Kwashiorkor
0.000 0.471 0.529
D69.2 Other nonthrombocytopenic purpura
0.000 0.472 0.528
I60 Subarachnoid haemorrhage
0.000 0.472 0.528
I67.9 Cerebrovascular disease, unspecified
0.000 0.473 0.527
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.476 0.524
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.476 0.524
E16.4 Abnormal secretion of gastrin
0.000 0.476 0.524
E16.3 Increased secretion of glucagon
0.000 0.476 0.524
E23.6 Other disorders of pituitary gland
0.000 0.477 0.523
G93.0 Cerebral cysts
0.000 0.478 0.522
G40-G47 Episodic and paroxysmal disorders
0.000 0.478 0.522
I67 Other cerebrovascular diseases
0.000 0.478 0.522
D69.8 Other specified haemorrhagic conditions
0.000 0.480 0.520
I63.3 Cerebral infarction due to thrombosis of cerebral arteries
0.000 0.482 0.518
E55 Vitamin D deficiency
0.000 0.482 0.518
G90.3 Multisystem degeneration
0.000 0.482 0.517
D67 Hereditary factor IX deficiency
0.000 0.485 0.515
E14.6 With other specified complications
0.000 0.485 0.514
G30-G32 Other degenerative diseases of the nervous system
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E30.9 Disorder of puberty, unspecified
0.000 0.486 0.514
E30.8 Other disorders of puberty
0.000 0.486 0.514
E30.1 Precocious puberty
0.000 0.486 0.514
E30.0 Delayed puberty
0.000 0.486 0.514
E31.9 Polyglandular dysfunction, unspecified
0.000 0.486 0.514
E31.8 Other polyglandular dysfunction
0.000 0.486 0.514
E31.1 Polyglandular hyperfunction
0.000 0.486 0.514
E31.0 Autoimmune polyglandular failure
0.000 0.486 0.514
E32.9 Disease of thymus, unspecified
0.000 0.486 0.514
E32.8 Other diseases of thymus
0.000 0.486 0.514
E32.1 Abscess of thymus
0.000 0.486 0.514
E32.0 Persistent hyperplasia of thymus
0.000 0.486 0.514
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.486 0.514
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.486 0.514
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.486 0.514
K73 Chronic hepatitis, not elsewhere classified
0.000 0.487 0.513
E23.2 Diabetes insipidus
0.000 0.487 0.513
G44 Other headache syndromes
0.000 0.488 0.512
G94 Other disorders of brain in diseases classified elsewhere
0.000 0.490 0.510
G81.1 Spastic hemiplegia
0.000 0.491 0.509
H06.3 Other disorders of orbit in diseases classified elsewhere
0.000 0.491 0.509
H06.1 Parasitic infestation of orbit in diseases classified elsewhere
0.000 0.491 0.509
H06.0 Disorders of lachrymal system in diseases classified elsewhere
0.000 0.491 0.509
D64 Other anaemias
0.000 0.493 0.507
E11.0 With coma
0.000 0.493 0.506
G92 Toxic encephalopathy
0.000 0.494 0.506
H05.8 Other disorders of orbit
0.000 0.496 0.504
G91.1 Obstructive hydrocephalus
0.000 0.497 0.503
H02.2 Lagophthalmos
0.000 0.497 0.503
G72 Other myopathies
0.000 0.498 0.502
H30.9 Chorioretinal inflammation, unspecified
0.000 0.499 0.501
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.499 0.501
H16.2 Keratoconjunctivitis
0.000 0.499 0.500
H16.1 Other superficial keratitis without conjunctivitis
0.000 0.500 0.500
G44.2 Tension-type headache
0.000 0.501 0.499
D66 Hereditary factor VIII deficiency
0.000 0.505 0.495
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.506 0.494
H15.8 Other disorders of sclera
0.000 0.507 0.493
H21 Other disorders of iris and ciliary body
0.000 0.507 0.493
D69.1 Qualitative platelet defects
0.000 0.507 0.493
H05.2 Exophthalmic conditions
0.000 0.509 0.491
G37.9 Demyelinating disease of central nervous system, unspecified
0.000 0.511 0.489
H16.8 Other keratitis
0.000 0.511 0.489
Chapter I Certain infectious and parasitic diseases
0.000 0.511 0.489
I60.9 Subarachnoid haemorrhage, unspecified
0.000 0.512 0.488
E06.5 Other chronic thyroiditis
0.000 0.512 0.487
E06.4 Drug-induced thyroiditis
0.000 0.512 0.487
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.512 0.487
E06.0 Acute thyroiditis
0.000 0.512 0.487
H05.0 Acute inflammation of orbit
0.000 0.515 0.485
L20-L30 Dermatitis and eczema
0.000 0.516 0.484
K75.0 Abscess of liver
0.000 0.516 0.484
G97.8 Other postprocedural disorders of nervous system
0.000 0.516 0.484
G91.8 Other hydrocephalus
0.000 0.516 0.484
D56 Thalassaemia
0.000 0.516 0.484
E22 Hyperfunction of pituitary gland
0.000 0.517 0.483
K74.5 Biliary cirrhosis, unspecified
0.000 0.517 0.483
D59 Acquired haemolytic anaemia
0.000 0.518 0.482
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.519 0.481
G91.9 Hydrocephalus, unspecified
0.000 0.519 0.481
G93.6 Cerebral oedema
0.000 0.519 0.481
I64 Stroke, not specified as haemorrhage or infarction
0.000 0.520 0.480
L29 Pruritus
0.000 0.521 0.479
E51 Thiamine deficiency
0.000 0.522 0.478
H46-H48 Disorders of optic nerve and visual pathways
0.000 0.522 0.478
I69 Sequelae of cerebrovascular disease
0.000 0.523 0.477
H44 Disorders of globe
0.000 0.523 0.477
K50.8 Other Crohn's disease
0.477 0.523 0.000
K74.0 Hepatic fibrosis
0.000 0.523 0.477
D68.0 Von Willebrand's disease
0.000 0.523 0.477
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.524 0.476
G36.0 Neuromyelitis optica [Devic]
0.000 0.526 0.474
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.527 0.473
E23.1 Drug-induced hypopituitarism
0.000 0.527 0.473
G83.9 Paralytic syndrome, unspecified
0.000 0.527 0.473
H31.1 Choroidal degeneration
0.000 0.527 0.473
G83.2 Monoplegia of upper limb
0.000 0.528 0.472
L29.0 Pruritus ani
0.000 0.529 0.471
H16.9 Keratitis, unspecified
0.000 0.531 0.469
H02.6 Xanthelasma of eyelid
0.000 0.531 0.469
E16.1 Other hypoglycaemia
0.000 0.533 0.467
H16.3 Interstitial and deep keratitis
0.000 0.534 0.466
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.534 0.466
H16.4 Corneal neovascularisation
0.000 0.535 0.465
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.535 0.465
E28.9 Ovarian dysfunction, unspecified
0.000 0.535 0.465
E28.8 Other ovarian dysfunction
0.000 0.535 0.465
E28.1 Androgen excess
0.000 0.535 0.465
E28.0 Oestrogen excess
0.000 0.535 0.465
I63.2 Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
0.000 0.536 0.464
H45 Disorders of vitreous body and globe in diseases classified elsewhere
0.000 0.536 0.464
K75.3 Granulomatous hepatitis, not elsewhere classified
0.000 0.537 0.463
K73.2 Chronic active hepatitis, not elsewhere classified
0.000 0.537 0.463
E29.9 Testicular dysfunction, unspecified
0.000 0.537 0.463
E29.8 Other testicular dysfunction
0.000 0.537 0.463
E29.0 Testicular hyperfunction
0.000 0.537 0.463
G96 Other disorders of central nervous system
0.000 0.539 0.461
D81.9 Combined immunodeficiency, unspecified
0.000 0.539 0.460
D81.8 Other combined immunodeficiencies
0.000 0.539 0.460
D81.7 Major histocompatibility complex class II deficiency
0.000 0.539 0.460
D81.6 Major histocompatibility complex class I deficiency
0.000 0.539 0.460
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.539 0.460
D81.4 Nezelof's syndrome
0.000 0.539 0.460
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.539 0.460
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.539 0.460
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.539 0.460
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.539 0.460
H31.0 Chorioretinal scars
0.000 0.539 0.461
E23.7 Disorder of pituitary gland, unspecified
0.000 0.540 0.460
E28.2 Polycystic ovarian syndrome
0.000 0.540 0.460
E04.1 Non-toxic single thyroid nodule
0.000 0.540 0.460
H03 Disorders of eyelid in diseases classified elsewhere
0.000 0.540 0.460
H19.3 Keratitis and keratoconjunctivitis in other diseases classified elsewhere
0.000 0.540 0.460
I60.2 Subarachnoid haemorrhage from anterior communicating artery
0.000 0.540 0.460
H35.1 Retinopathy of prematurity
0.000 0.541 0.459
D64.9 Anaemia, unspecified
0.000 0.542 0.458
B35-B49 Mycoses
0.000 0.542 0.458
K75.2 Nonspecific reactive hepatitis
0.000 0.543 0.457
K75.1 Phlebitis of portal vein
0.000 0.543 0.457
D69.9 Haemorrhagic condition, unspecified
0.000 0.543 0.457
G36.9 Acute disseminated demyelination, unspecified
0.000 0.543 0.457
G36.8 Other specified acute disseminated demyelination
0.000 0.543 0.457
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.000 0.543 0.457
D68.5 Primary Thrombophilia
0.000 0.543 0.457
H31.3 Choroidal haemorrhage and rupture
0.000 0.545 0.455
D55 Anaemia due to enzyme disorders
0.000 0.545 0.454
L27 Dermatitis due to substances taken internally
0.000 0.545 0.455
G44.0 Cluster headache syndrome
0.000 0.546 0.454
H19.1 Herpesviral keratitis and keratoconjunctivitis
0.000 0.548 0.452
K77 Liver disorders in diseases classified elsewhere
0.000 0.549 0.451
G83.8 Other specified paralytic syndromes
0.000 0.550 0.450
B37.8 Candidiasis of other sites
0.000 0.550 0.450
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.550 0.450
E63 Other nutritional deficiencies
0.000 0.550 0.450
E50 Vitamin A deficiency
0.000 0.550 0.450
E60 Dietary zinc deficiency
0.000 0.550 0.450
E59 Dietary selenium deficiency
0.000 0.550 0.450
E54 Ascorbic acid deficiency
0.000 0.550 0.450
E52 Niacin deficiency [pellagra]
0.000 0.550 0.450
H05.5 Retained (old) foreign body following penetrating wound of orbit
0.000 0.550 0.450
H05.3 Deformity of orbit
0.000 0.550 0.450
H05.1 Chronic inflammatory disorders of orbit
0.000 0.550 0.450
B37 Candidiasis
0.000 0.551 0.449
L21 Seborrhoeic dermatitis
0.000 0.552 0.448
D53.8 Other specified nutritional anaemias
0.000 0.553 0.447
D53.2 Scorbutic anaemia
0.000 0.553 0.447
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.553 0.447
D53.0 Protein deficiency anaemia
0.000 0.553 0.447
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.553 0.446
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.553 0.446
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.553 0.446
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.553 0.446
D82.2 Immunodeficiency with short-limbed stature
0.000 0.553 0.446
D82.0 Wiskott-Aldrich syndrome
0.000 0.553 0.446
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.000 0.555 0.445
I69.3 Sequelae of cerebral infarction
0.000 0.555 0.445
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.556 0.444
G81.0 Flaccid hemiplegia
0.000 0.556 0.444
K72 Hepatic failure, not elsewhere classified
0.000 0.556 0.443
D68.9 Coagulation defect, unspecified
0.000 0.558 0.442
H43.9 Disorder of vitreous body, unspecified
0.000 0.558 0.442
G91.2 Normal-pressure hydrocephalus
0.000 0.558 0.442
E55.9 Vitamin D deficiency, unspecified
0.000 0.560 0.440
D53.9 Nutritional anaemia, unspecified
0.000 0.561 0.439
H17 Corneal scars and opacities
0.000 0.561 0.439
G90.8 Other disorders of autonomic nervous system
0.000 0.561 0.438
G90.4 Autonomic dysreflexia
0.000 0.561 0.438
G90.1 Familial dysautonomia [Riley-Day]
0.000 0.561 0.438
E11.5 With peripheral circulatory complications
0.000 0.562 0.438
I63.5 Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
0.000 0.563 0.437
H30.8 Other chorioretinal inflammations
0.000 0.563 0.437
H30.2 Posterior cyclitis
0.000 0.563 0.437
H30.1 Disseminated chorioretinal inflammation
0.000 0.563 0.437
H30.0 Focal chorioretinal inflammation
0.000 0.563 0.437
B25-B34 Other viral diseases
0.000 0.564 0.436
G37.5 Concentric sclerosis [Balo]
0.000 0.566 0.434
G37.4 Subacute necrotising myelitis
0.000 0.566 0.434
G37.2 Central pontine myelinolysis
0.000 0.566 0.434
G37.1 Central demyelination of corpus callosum
0.000 0.566 0.434
G37.0 Diffuse sclerosis
0.000 0.566 0.434
H05.4 Enophthalmos
0.000 0.566 0.434
E26.8 Other hyperaldosteronism
0.000 0.567 0.433
E26.1 Secondary hyperaldosteronism
0.000 0.567 0.433
L27.0 Generalised skin eruption due to drugs and medicaments
0.000 0.567 0.433
G91.3 Posttraumatic hydrocephalus, unspecified
0.000 0.567 0.433
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.568 0.432
E03.8 Other specified hypothyroidism
0.001 0.569 0.431
E56 Other vitamin deficiencies
0.000 0.569 0.431
I60.0 Subarachnoid haemorrhage from carotid siphon and bifurcation
0.000 0.570 0.430
D89.3 Immune reconstitution syndrome
0.000 0.570 0.430
H22 Disorders of iris and ciliary body in diseases classified elsewhere
0.000 0.570 0.430
H31.4 Choroidal detachment
0.000 0.570 0.429
H31.2 Hereditary choroidal dystrophy
0.000 0.570 0.429
H35.6 Retinal haemorrhage
0.000 0.571 0.429
I62 Other nontraumatic intracranial haemorrhage
0.000 0.572 0.428
H05.9 Disorder of orbit, unspecified
0.000 0.572 0.428
K74.6 Other and unspecified cirrhosis of liver
0.000 0.572 0.428
D82.1 Di George's syndrome
0.000 0.573 0.427
E13 Other specified diabetes mellitus
0.001 0.574 0.425
E24.8 Other Cushing's syndrome
0.000 0.574 0.426
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.574 0.426
E24.3 Ectopic ACTH syndrome
0.000 0.574 0.426
E24.1 Nelson's syndrome
0.000 0.574 0.426
H21.0 Hyphaema
0.000 0.574 0.426
E24.0 Pituitary-dependent Cushing's disease
0.000 0.574 0.425
G93.5 Compression of brain
0.000 0.574 0.425
E58 Dietary calcium deficiency
0.000 0.576 0.424
I68 Cerebrovascular disorders in diseases classified elsewhere
0.000 0.577 0.423
G37.8 Other specified demyelinating diseases of central nervous system
0.000 0.578 0.422
L21.9 Seborrhoeic dermatitis, unspecified
0.000 0.578 0.422
D57 Sickle-cell disorders
0.000 0.579 0.420
E06.1 Subacute thyroiditis
0.000 0.579 0.420
B90-B94 Sequelae of infectious and parasitic diseases
0.000 0.580 0.420
G93.7 Reye's syndrome
0.000 0.582 0.417
D58 Other hereditary haemolytic anaemias
0.000 0.583 0.417
L29.8 Other pruritus
0.000 0.583 0.417
E65-E68 Obesity and other hyperalimentation
0.000 0.584 0.416
H21.1 Other vascular disorders of iris and ciliary body
0.000 0.584 0.416
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.000 0.584 0.416
G31.8 Other specified degenerative diseases of nervous system
0.000 0.585 0.415
G72.4 Inflammatory myopathy, not elsewhere classified
0.000 0.586 0.414
H43.2 Crystalline deposits in vitreous body
0.000 0.587 0.412
H44.1 Other endophthalmitis
0.000 0.589 0.411

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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