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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs35724370
log Bayes Factor = 16.3571
Chromosome 21   position 29,751,778  (GRCh37) Explore rs35724370 on Ensembl!
Variant rs35724370 is part of Cluster X0029

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter XI Diseases of the digestive system
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.997 0.003 0.000
M20-M25 Other joint disorders
0.996 0.004 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.994 0.006 0.000
Chapter V Mental and behavioural disorders
0.991 0.009 0.000
M05-M14 Inflammatory polyarthropathies
0.991 0.009 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.988 0.012 0.000
M15-M19 Arthrosis
0.988 0.012 0.000
M17 Gonarthrosis [arthrosis of knee]
0.985 0.015 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.982 0.018 0.000
K70-K77 Diseases of liver
0.979 0.021 0.000
K80-K87 Disorders of gallbladder, biliary tract and pancreas
0.978 0.022 0.000
R50-R69 General symptoms and signs
0.977 0.023 0.000
M17.9 Gonarthrosis, unspecified
0.975 0.025 0.000
M50-M54 Other dorsopathies
0.972 0.028 0.000
R59 Enlarged lymph nodes
0.972 0.028 0.000
Chapter XX External causes of morbidity and mortality
0.967 0.033 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.964 0.036 0.000
K90-K93 Other diseases of the digestive system
0.958 0.042 0.000
R59.0 Localised enlarged lymph nodes
0.955 0.045 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.952 0.048 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.952 0.048 0.000
K76 Other diseases of liver
0.949 0.051 0.000
M54 Dorsalgia
0.946 0.054 0.000
Chapter I Certain infectious and parasitic diseases
0.944 0.056 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.942 0.058 0.000
M70-M79 Other soft tissue disorders
0.939 0.061 0.000
M13 Other arthritis
0.938 0.062 0.000
R42 Dizziness and giddiness
0.931 0.069 0.000
M06 Other rheumatoid arthritis
0.929 0.071 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.924 0.076 0.000
M25 Other joint disorders, not elsewhere classified
0.924 0.076 0.000
K76.9 Liver disease, unspecified
0.924 0.076 0.000
K55-K64 Other diseases of intestines
0.922 0.078 0.000
F10 Mental and behavioural disorders due to use of alcohol
0.917 0.083 0.000
K92 Other diseases of digestive system
0.914 0.086 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.913 0.087 0.000
K50-K52 Noninfective enteritis and colitis
0.913 0.087 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.905 0.095 0.000
M54.5 Low back pain
0.904 0.096 0.000
K58 Irritable bowel syndrome
0.903 0.097 0.000
D60-D64 Aplastic and other anaemias
0.902 0.098 0.000
R59.1 Generalised enlarged lymph nodes
0.902 0.098 0.000
E70-E90 Metabolic disorders
0.899 0.101 0.000
K80 Cholelithiasis
0.899 0.101 0.000
Chapter XIV Diseases of the genitourinary system
0.899 0.101 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.896 0.104 0.000
D69 Purpura and other haemorrhagic conditions
0.895 0.105 0.000
M13.9 Arthritis, unspecified
0.892 0.108 0.000
M17.1 Other primary gonarthrosis
0.890 0.110 0.000
K50 Crohn's disease [regional enteritis]
0.888 0.112 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.888 0.112 0.000
M45-M49 Spondylopathies
0.888 0.112 0.000
M21 Other acquired deformities of limbs
0.886 0.114 0.000
K85 Acute pancreatitis
0.885 0.115 0.000
K58.9 Irritable bowel syndrome without diarrhoea
0.883 0.117 0.000
N17-N19 Renal failure
0.881 0.119 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.880 0.120 0.000
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts
0.876 0.124 0.000
M79.6 Pain in limb
0.876 0.124 0.000
K92.2 Gastro-intestinal haemorrhage, unspecified
0.875 0.125 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.875 0.125 0.000
M06.9 Rheumatoid arthritis, unspecified
0.875 0.125 0.000
F60-F69 Disorders of adult personality and behaviour
0.870 0.130 0.000
D50-D53 Nutritional anaemias
0.868 0.132 0.000
N17 Acute renal failure
0.865 0.135 0.000
K50.9 Crohn's disease, unspecified
0.862 0.138 0.000
E87.1 Hypo-osmolality and hyponatraemia
0.861 0.139 0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems
0.858 0.142 0.000
K86 Other diseases of pancreas
0.857 0.143 0.000
N17.9 Acute renal failure, unspecified
0.855 0.145 0.000
T81 Complications of procedures, not elsewhere classified
0.850 0.150 0.000
F17 Mental and behavioural disorders due to use of tobacco
0.849 0.151 0.000
Chapter X Diseases of the respiratory system
0.849 0.151 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.849 0.151 0.000
Chapter IX Diseases of the circulatory system
0.848 0.152 0.000
N25-N29 Other disorders of kidney and ureter
0.848 0.152 0.000
Chapter II Neoplasms
0.847 0.153 0.000
M54.56 Low back pain (Lumbar region)
0.845 0.155 0.000
Y95 Nosocomial condition
0.845 0.155 0.000
S20-S29 Injuries to the thorax
0.844 0.155 0.000
K56 Paralytic ileus and intestinal obstruction without hernia
0.844 0.156 0.000
M35 Other systemic involvement of connective tissue
0.842 0.158 0.000
R93 Abnormal findings on diagnostic imaging of other body structures
0.840 0.160 0.000
T66-T78 Other and unspecified effects of external causes
0.839 0.161 0.000
B95-B98 Bacterial, viral and other infectious agents
0.838 0.162 0.000
R07 Pain in throat and chest
0.837 0.163 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.834 0.166 0.000
K60 Fissure and fistula of anal and rectal regions
0.832 0.168 0.000
R56 Convulsions, not elsewhere classified
0.832 0.168 0.000
M25.4 Effusion of joint
0.830 0.170 0.000
J09-J18 Influenza and pneumonia
0.829 0.171 0.000
M13.96 Arthritis, unspecified (Lower leg)
0.828 0.172 0.000
M10 Gout
0.827 0.173 0.000
K65-K67 Diseases of peritoneum
0.824 0.176 0.000
R50 Fever of unknown origin
0.823 0.177 0.000
R52 Pain, not elsewhere classified
0.822 0.178 0.000
R07.4 Chest pain, unspecified
0.822 0.178 0.000
C15-C26 Malignant neoplasms of digestive organs
0.822 0.178 0.000
L03 Cellulitis
0.822 0.178 0.000
T84.6 Infection and inflammatory reaction due to internal fixation device [any site]
0.821 0.179 0.000
M22 Disorders of patella
0.819 0.181 0.000
J18 Pneumonia, organism unspecified
0.817 0.183 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.816 0.184 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.812 0.188 0.000
N28 Other disorders of kidney and ureter, not elsewhere classified
0.811 0.189 0.000
D69.3 Idiopathic thrombocytopenic purpura
0.810 0.190 0.000
S40-S49 Injuries to the shoulder and upper arm
0.809 0.191 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.808 0.192 0.000
K85.9 Acute pancreatitis, unspecified
0.808 0.192 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.808 0.192 0.000
R61 Hyperhidrosis
0.807 0.193 0.000
I73 Other peripheral vascular diseases
0.805 0.195 0.000
M50 Cervical disk disorders
0.805 0.195 0.000
N10-N16 Renal tubulo-interstitial diseases
0.802 0.198 0.000
M79.8 Other specified soft tissue disorders
0.802 0.198 0.000
K35-K38 Diseases of appendix
0.801 0.199 0.000
M23 Internal derangement of knee
0.798 0.202 0.000
M24 Other specific joint derangements
0.798 0.202 0.000
M17.0 Primary gonarthrosis, bilateral
0.797 0.203 0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters
0.796 0.204 0.000
D69.6 Thrombocytopenia, unspecified
0.796 0.204 0.000
F10.1 Harmful use
0.794 0.206 0.000
F30-F39 Mood [affective] disorders
0.794 0.206 0.000
W20-W49 Exposure to inanimate mechanical forces
0.793 0.206 0.000
M20 Acquired deformities of fingers and toes
0.793 0.207 0.000
K60.2 Anal fissure, unspecified
0.792 0.208 0.000
K80.2 Calculus of gallbladder without cholecystitis
0.791 0.209 0.000
T84.0 Mechanical complication of internal joint prosthesis
0.790 0.210 0.000
K91 Postprocedural disorders of digestive system, not elsewhere classified
0.789 0.211 0.000
F17.1 Harmful use
0.787 0.213 0.000
S90-S99 Injuries to the ankle and foot
0.785 0.215 0.000
K76.6 Portal hypertension
0.785 0.215 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.785 0.215 0.000
M40-M43 Deforming dorsopathies
0.784 0.215 0.000
F60 Specific personality disorders
0.784 0.216 0.000
K92.1 Melaena
0.783 0.217 0.000
J18.1 Lobar pneumonia, unspecified
0.783 0.217 0.000
M65-M68 Disorders of synovium and tendon
0.783 0.217 0.000
K70 Alcoholic liver disease
0.781 0.219 0.000
M79.67 Pain in limb (Ankle and foot)
0.781 0.219 0.000
T81.4 Infection following a procedure, not elsewhere classified
0.780 0.220 0.000
K80.1 Calculus of gallbladder with other cholecystitis
0.777 0.223 0.000
M25.7 Osteophyte
0.777 0.223 0.000
A00-A09 Intestinal infectious diseases
0.777 0.223 0.000
M54.57 Low back pain (Lumbosacral region)
0.775 0.225 0.000
F80-F89 Disorders of psychological development
0.773 0.226 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.769 0.231 0.000
Chapter XXII Codes for special purposes
0.769 0.231 0.000
K76.0 Fatty (change of) liver, not elsewhere classified
0.768 0.232 0.000
F99-F99 Unspecified mental disorder
0.768 0.232 0.000
K74 Fibrosis and cirrhosis of liver
0.767 0.233 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.767 0.233 0.000
D62 Acute posthaemorrhagic anaemia
0.767 0.233 0.000
M91-M94 Chondropathies
0.764 0.235 0.000
I73.0 Raynaud's syndrome
0.764 0.236 0.000
M25.8 Other specified joint disorders
0.762 0.238 0.000
D80-D89 Certain disorders involving the immune mechanism
0.762 0.238 0.000
R93.3 Abnormal findings on diagnostic imaging of other parts of digestive tract
0.762 0.238 0.000
S70-S79 Injuries to the hip and thigh
0.761 0.239 0.000
M54.9 Dorsalgia, unspecified
0.760 0.240 0.000
M13.94 Arthritis, unspecified (Hand)
0.760 0.240 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.759 0.241 0.000
M25.46 Effusion of joint (Lower leg)
0.755 0.245 0.000
F10.3 Withdrawal state
0.754 0.246 0.000
J18.9 Pneumonia, unspecified
0.754 0.246 0.000
M34 Systemic sclerosis
0.753 0.247 0.000
E86 Volume depletion
0.751 0.249 0.000
L03.1 Cellulitis of other parts of limb
0.750 0.250 0.000
T86 Failure and rejection of transplanted organs and tissues
0.749 0.250 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.748 0.251 0.000
T79-T79 Certain early complications of trauma
0.748 0.252 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.748 0.252 0.000
M54.3 Sciatica
0.748 0.252 0.000
E88 Other metabolic disorders
0.747 0.253 0.000
D64 Other anaemias
0.746 0.254 0.000
K50.0 Crohn's disease of small intestine
0.746 0.254 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.744 0.256 0.000
C15 Malignant neoplasm of oesophagus
0.744 0.256 0.000
M86-M90 Other osteopathies
0.742 0.258 0.000
L02 Cutaneous abscess, furuncle and carbuncle
0.741 0.259 0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.741 0.259 0.000
M05 Seropositive rheumatoid arthritis
0.738 0.262 0.000
D50 Iron deficiency anaemia
0.738 0.262 0.000
T81.8 Other complications of procedures, not elsewhere classified
0.738 0.262 0.000
M46 Other inflammatory spondylopathies
0.736 0.264 0.000
M79.0 Rheumatism, unspecified
0.736 0.264 0.000
M79.1 Myalgia
0.736 0.264 0.000
K56.5 Intestinal adhesions [bands] with obstruction
0.735 0.265 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.732 0.268 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.731 0.268 0.000
K58.0 Irritable bowel syndrome with diarrhoea
0.731 0.269 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.730 0.270 0.000
R09 Other symptoms and signs involving the circulatory and respiratory systems
0.730 0.270 0.000
M13.90 Arthritis, unspecified (Multiple sites)
0.730 0.270 0.000
D68 Other coagulation defects
0.729 0.271 0.000
M21.4 Flat foot [pes planus] (acquired)
0.729 0.271 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.728 0.272 0.000
Chapter VII Diseases of the eye and adnexa
0.728 0.272 0.000
T84.2 Mechanical complication of internal fixation device of other bones
0.728 0.272 0.000
R56.8 Other and unspecified convulsions
0.728 0.272 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.728 0.272 0.000
E73 Lactose intolerance
0.727 0.273 0.000
M21.1 Varus deformity, not elsewhere classified
0.726 0.274 0.000
T78 Adverse effects, not elsewhere classified
0.726 0.274 0.000
A30-A49 Other bacterial diseases
0.725 0.275 0.000
F10.2 Dependence syndrome
0.725 0.275 0.000
K75 Other inflammatory liver diseases
0.724 0.276 0.000
K56.7 Ileus, unspecified
0.724 0.276 0.000
K56.6 Other and unspecified intestinal obstruction
0.723 0.277 0.000
M79.66 Pain in limb (Lower leg)
0.722 0.278 0.000
M35.3 Polymyalgia rheumatica
0.721 0.278 0.000
S50-S59 Injuries to the elbow and forearm
0.721 0.278 0.000
M13.0 Polyarthritis, unspecified
0.721 0.279 0.000
F10.4 Withdrawal state with delirium
0.721 0.279 0.000
M18 Arthrosis of first carpometacarpal joint
0.720 0.280 0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis
0.719 0.280 0.000
M11 Other crystal arthropathies
0.719 0.281 0.000
D63 Anaemia in chronic diseases classified elsewhere
0.718 0.282 0.000
N00-N08 Glomerular diseases
0.718 0.282 0.000
B35-B49 Mycoses
0.717 0.283 0.000
M60-M63 Disorders of muscles
0.717 0.283 0.000
M00-M03 Infectious arthropathies
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.716 0.284 0.000
T83.1 Mechanical complication of other urinary devices and implants
0.716 0.284 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.715 0.285 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.715 0.285 0.000
S80-S89 Injuries to the knee and lower leg
0.715 0.285 0.000
T33-T35 Frostbite
0.715 0.285 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.715 0.285 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.715 0.285 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.715 0.285 0.000
T00-T07 Injuries involving multiple body regions
0.715 0.285 0.000
S10-S19 Injuries to the neck
0.715 0.285 0.000
X60-X84 Intentional self-harm
0.715 0.285 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.714 0.286 0.000
M33 Dermatopolymyositis
0.714 0.286 0.000
M32 Systemic lupus erythematosus
0.714 0.286 0.000
M30 Polyarteritis nodosa and related conditions
0.714 0.286 0.000
B95.6 Staphylococcus aureus as the cause of diseases classified to other chapters
0.714 0.286 0.000
M06.0 Seronegative rheumatoid arthritis
0.713 0.286 0.000
R07.2 Precordial pain
0.713 0.287 0.000
D55-D59 Haemolytic anaemias
0.713 0.287 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.713 0.287 0.000
F10.0 Acute intoxication
0.713 0.287 0.000
R59.9 Enlarged lymph nodes, unspecified
0.711 0.289 0.000
K86.3 Pseudocyst of pancreas
0.711 0.289 0.000
S22 Fracture of rib(s), sternum and thoracic spine
0.711 0.289 0.000
E87.0 Hyperosmolality and hypernatraemia
0.711 0.289 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.710 0.289 0.000
F70-F79 Mental retardation
0.710 0.289 0.000
M14 Arthropathies in other diseases classified elsewhere
0.710 0.289 0.000
M12 Other specific arthropathies
0.710 0.289 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.710 0.289 0.000
M08 Juvenile arthritis
0.710 0.289 0.000
M48 Other spondylopathies
0.710 0.290 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.710 0.290 0.000
M10.9 Gout, unspecified
0.709 0.291 0.000
K86.0 Alcohol-induced chronic pancreatitis
0.709 0.291 0.000
C64-C68 Malignant neoplasms of urinary tract
0.709 0.291 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.708 0.292 0.000
M15 Polyarthrosis
0.708 0.292 0.000
R47-R49 Symptoms and signs involving speech and voice
0.708 0.292 0.000
M79.62 Pain in limb (Upper arm)
0.708 0.292 0.000
M54.1 Radiculopathy
0.707 0.292 0.000
M54.50 Low back pain (Multiple sites in spine)
0.707 0.293 0.000
M17.5 Other secondary gonarthrosis
0.706 0.294 0.000
M17.4 Other secondary gonarthrosis, bilateral
0.706 0.294 0.000
M17.3 Other posttraumatic gonarthrosis
0.706 0.294 0.000
M17.2 Posttraumatic gonarthrosis, bilateral
0.706 0.294 0.000
K80.0 Calculus of gallbladder with acute cholecystitis
0.705 0.295 0.000
I74 Arterial embolism and thrombosis
0.705 0.295 0.000
M13.95 Arthritis, unspecified (Pelvic region and thigh)
0.705 0.295 0.000
T87 Complications peculiar to reattachment and amputation
0.704 0.296 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.704 0.296 0.000
K77 Liver disorders in diseases classified elsewhere
0.702 0.298 0.000
K73 Chronic hepatitis, not elsewhere classified
0.702 0.298 0.000
K72 Hepatic failure, not elsewhere classified
0.702 0.298 0.000
K71 Toxic liver disease
0.702 0.298 0.000
K87 Disorders of gallbladder, biliary tract and pancreas in diseases classified elsewhere
0.701 0.298 0.000
R65 Systemic Inflammatory Response Syndrome [SIRS]
0.701 0.299 0.000
R62 Lack of expected normal physiological development
0.701 0.299 0.000
R57 Shock, not elsewhere classified
0.701 0.299 0.000
R64 Cachexia
0.701 0.299 0.000
R58 Haemorrhage, not elsewhere classified
0.701 0.299 0.000
N28.8 Other specified disorders of kidney and ureter
0.701 0.299 0.000
M79.63 Pain in limb (Forearm)
0.700 0.300 0.000
M21.0 Valgus deformity, not elsewhere classified
0.700 0.300 0.000
E87.7 Fluid overload
0.699 0.301 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.698 0.302 0.000
L05 Pilonidal cyst
0.697 0.303 0.000
M53 Other dorsopathies, not elsewhere classified
0.697 0.303 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.697 0.303 0.000
K81 Cholecystitis
0.696 0.304 0.000
E87.2 Acidosis
0.695 0.305 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.693 0.307 0.000
Y35-Y36 Legal intervention and operations of war
0.693 0.307 0.000
Y10-Y34 Event of undetermined intent
0.693 0.307 0.000
Y00-Y09 Assault
0.693 0.307 0.000
X85-X99 Assault
0.693 0.307 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.693 0.307 0.000
X50-X57 Overexertion, travel and privation
0.693 0.307 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.693 0.307 0.000
X30-X39 Exposure to forces of nature
0.693 0.307 0.000
X20-X29 Contact with venomous animals and plants
0.693 0.307 0.000
X10-X19 Contact with heat and hot substances
0.693 0.307 0.000
X00-X09 Exposure to smoke, fire and flames
0.693 0.307 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.693 0.307 0.000
W75-W84 Other accidental threats to breathing
0.693 0.307 0.000
W65-W74 Accidental drowning and submersion
0.693 0.307 0.000
W50-W64 Exposure to animate mechanical forces
0.693 0.307 0.000
V98-V99 Other and unspecified transport accidents
0.693 0.307 0.000
V95-V97 Air and space transport accidents
0.693 0.307 0.000
V90-V94 Water transport accidents
0.693 0.307 0.000
V80-V89 Other land transport accidents
0.693 0.307 0.000
V70-V79 Bus occupant injured in transport accident
0.693 0.307 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.693 0.307 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.693 0.307 0.000
V40-V49 Car occupant injured in transport accident
0.693 0.307 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.693 0.307 0.000
V20-V29 Motorcycle rider injured in transport accident
0.693 0.307 0.000
V01-V09 Pedestrian injured in transport accident
0.693 0.307 0.000
R68 Other general symptoms and signs
0.693 0.307 0.000
F60.9 Personality disorder, unspecified
0.693 0.307 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.693 0.307 0.000
R45 Symptoms and signs involving emotional state
0.692 0.308 0.000
I73.9 Peripheral vascular disease, unspecified
0.692 0.308 0.000
N12 Tubulo-interstitial nephritis, not specified as acute or chronic
0.692 0.308 0.000
F19 Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances
0.691 0.309 0.000
F18 Mental and behavioural disorders due to use of volatile solvents
0.691 0.309 0.000
F16 Mental and behavioural disorders due to use of hallucinogens
0.691 0.309 0.000
F15 Mental and behavioural disorders due to use of other stimulants, including caffeine
0.691 0.309 0.000
F14 Mental and behavioural disorders due to use of cocaine
0.691 0.309 0.000
F13 Mental and behavioural disorders due to use of sedatives or hypnotics
0.691 0.309 0.000
F12 Mental and behavioural disorders due to use of cannabinoids
0.691 0.309 0.000
F11 Mental and behavioural disorders due to use of opioids
0.691 0.309 0.000
I60-I69 Cerebrovascular diseases
0.691 0.309 0.000
R52.1 Chronic intractable pain
0.689 0.311 0.000
M80-M85 Disorders of bone density and structure
0.689 0.311 0.000
R93.2 Abnormal findings on diagnostic imaging of liver and biliary tract
0.688 0.312 0.000
K35 Acute appendicitis
0.688 0.312 0.000
M07 Psoriatic and enteropathic arthropathies
0.688 0.312 0.000
M79.5 Residual foreign body in soft tissue
0.687 0.313 0.000
M31 Other necrotising vasculopathies
0.687 0.313 0.000
C19 Malignant neoplasm of rectosigmoid junction
0.687 0.313 0.000
K93 Disorders of other digestive organs in diseases classified elsewhere
0.687 0.313 0.000
B97 Viral agents as the cause of diseases classified to other chapters
0.687 0.313 0.000
J40-J47 Chronic lower respiratory diseases
0.686 0.314 0.000
R61.9 Hyperhidrosis, unspecified
0.686 0.314 0.000
M54.2 Cervicalgia
0.685 0.315 0.000
B95.3 Streptococcus pneumoniae as the cause of diseases classified to other chapters
0.684 0.316 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.683 0.317 0.000
T84.9 Unspecified complication of internal orthopaedic prosthetic device, implant and graft
0.683 0.317 0.000
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts
0.683 0.317 0.000
T84.4 Mechanical complication of other internal orthopaedic devices, imnplants and grafts
0.683 0.317 0.000
T84.3 Mechanical complication of other bone devices, implants and grafts
0.683 0.317 0.000
R46 Symptoms and signs involving appearance and behaviour
0.682 0.318 0.000
R43 Disturbances of smell and taste
0.682 0.318 0.000
C25 Malignant neoplasm of pancreas
0.682 0.318 0.000
R93.4 Abnormal findings on diagnostic imaging of urinary organs
0.682 0.318 0.000
E65-E68 Obesity and other hyperalimentation
0.682 0.318 0.000
M13.98 Arthritis, unspecified (Other)
0.681 0.319 0.000
K76.7 Hepatorenal syndrome
0.680 0.320 0.000
K76.5 Hepatic veno-occlusive disease
0.680 0.320 0.000
K76.4 Peliosis hepatis
0.680 0.320 0.000
K76.3 Infarction of liver
0.680 0.320 0.000
K76.2 Central haemorrhagic necrosis of liver
0.680 0.320 0.000
K76.1 Chronic passive congestion of liver
0.680 0.320 0.000
M77 Other enthesopathies
0.680 0.320 0.000
K82 Other diseases of gallbladder
0.680 0.320 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.679 0.321 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.679 0.321 0.000
L03.3 Cellulitis of trunk
0.678 0.321 0.000
M54.8 Other dorsalgia
0.678 0.322 0.000
M54.6 Pain in thoracic spine
0.678 0.322 0.000
M54.0 Panniculitis affecting regions of neck and back
0.678 0.322 0.000
R02 Gangrene, not elsewhere classified
0.678 0.322 0.000
D51 Vitamin B12 deficiency anaemia
0.678 0.322 0.000
N28.0 Ischaemia and infarction of kidney
0.677 0.323 0.000
B99-B99 Other infectious diseases
0.677 0.323 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.677 0.323 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.677 0.323 0.000
B65-B83 Helminthiases
0.677 0.323 0.000
B50-B64 Protozoal diseases
0.677 0.323 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.677 0.323 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.677 0.323 0.000
A80-A89 Viral infections of the central nervous system
0.677 0.323 0.000
A75-A79 Rickettsioses
0.677 0.323 0.000
A70-A74 Other diseases caused by chlamydiae
0.677 0.323 0.000
A65-A69 Other spirochaetal diseases
0.677 0.323 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.677 0.323 0.000
A20-A28 Certain zoonotic bacterial diseases
0.677 0.323 0.000
A15-A19 Tuberculosis
0.677 0.323 0.000
R60 Oedema, not elsewhere classified
0.676 0.323 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.676 0.324 0.000
D67 Hereditary factor IX deficiency
0.675 0.324 0.000
D66 Hereditary factor VIII deficiency
0.675 0.324 0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.675 0.324 0.000
R07.1 Chest pain on breathing
0.675 0.325 0.000
K66 Other disorders of peritoneum
0.675 0.325 0.000
M54.4 Lumbago with sciatica
0.675 0.325 0.000
D50.9 Iron deficiency anaemia, unspecified
0.674 0.326 0.000
R40 Somnolence, stupor and coma
0.674 0.326 0.000
M45 Ankylosing spondylitis
0.674 0.326 0.000
L60-L75 Disorders of skin appendages
0.674 0.326 0.000
M76 Enthesopathies of lower limb, excluding foot
0.673 0.327 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.673 0.327 0.000
M71 Other bursopathies
0.673 0.327 0.000
K86.1 Other chronic pancreatitis
0.673 0.327 0.000
M13.8 Other specified arthritis
0.673 0.327 0.000
M13.1 Monoarthritis, not elsewhere classified
0.673 0.327 0.000
R50.9 Fever, unspecified
0.672 0.328 0.000
M79.89 Other specified soft tissue disorders (Site unspecified)
0.672 0.328 0.000
W00-W19 Falls
0.672 0.328 0.000
K80.4 Calculus of bile duct with cholecystitis
0.671 0.329 0.000
V10-V19 Pedal cyclist injured in transport accident
0.669 0.330 0.000
K91.8 Other postprocedural disorders of digestive system, not elsewhere classified
0.669 0.331 0.000
N28.1 Cyst of kidney, acquired
0.669 0.331 0.000
M20.4 Other hammer toe(s) (acquired)
0.669 0.331 0.000
K55 Vascular disorders of intestine
0.667 0.333 0.000
N18 Chronic renal failure
0.667 0.333 0.000
K85.1 Biliary acute pancreatitis
0.667 0.333 0.000
M06.8 Other specified rheumatoid arthritis
0.666 0.334 0.000
M06.4 Inflammatory polyarthropathy
0.666 0.334 0.000
M06.3 Rheumatoid nodule
0.666 0.334 0.000
M06.2 Rheumatoid bursitis
0.666 0.334 0.000
M06.1 Adult-onset Still's disease
0.666 0.334 0.000
C15.9 Oesophagus, unspecified
0.666 0.334 0.000
Y86 Sequelae of other accidents
0.665 0.335 0.000
M47 Spondylosis
0.665 0.335 0.000
M79.7 Fibromyalgia
0.665 0.335 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.664 0.336 0.000
M79.9 Soft tissue disorder, unspecified
0.663 0.337 0.000
M79.4 Hypertrophy of (infrapatellar) fat pad
0.663 0.337 0.000
M79.3 Panniculitis, unspecified
0.663 0.337 0.000
M79.2 Neuralgia and neuritis, unspecified
0.663 0.337 0.000
K90 Intestinal malabsorption
0.663 0.337 0.000
M25.9 Joint disorder, unspecified
0.662 0.337 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.662 0.337 0.000
M25.3 Other instability of joint
0.662 0.337 0.000
M25.2 Flail joint
0.662 0.337 0.000
M25.1 Fistula of joint
0.662 0.337 0.000
M25.0 Haemarthrosis
0.662 0.337 0.000
L80-L99 Other disorders of the skin and subcutaneous tissue
0.662 0.338 0.000
R50.8 Other specified fever
0.662 0.338 0.000
N28.9 Disorder of kidney and ureter, unspecified
0.661 0.339 0.000
B15-B19 Viral hepatitis
0.661 0.339 0.000
N13 Obstructive and reflux uropathy
0.661 0.339 0.000
K64 Haemorrhoids and perianal venous thrombosis
0.661 0.339 0.000
M22.2 Patellofemoral disorders
0.661 0.339 0.000
K70.9 Alcoholic liver disease, unspecified
0.660 0.340 0.000
C26 Malignant neoplasm of other and ill-defined digestive organs
0.660 0.340 0.000
T83.0 Mechanical complication of urinary (indwelling) catheter
0.659 0.341 0.000
D72 Other disorders of white blood cells
0.658 0.342 0.000
I71 Aortic aneurysm and dissection
0.658 0.342 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.658 0.342 0.000
M79.87 Other specified soft tissue disorders (Ankle and foot)
0.657 0.342 0.000
F10.9 Unspecified mental and behavioural disorder
0.657 0.343 0.000
F10.8 Other mental and behavioural disorders
0.657 0.343 0.000
F10.7 Residual and late-onset psychotic disorder
0.657 0.343 0.000
F10.6 Amnesic syndrome
0.657 0.343 0.000
F10.5 Psychotic disorder
0.657 0.343 0.000
F32 Depressive episode
0.656 0.344 0.000
M24.1 Other articular cartilage disorders
0.656 0.344 0.000
R90 Abnormal findings on diagnostic imaging of central nervous system
0.656 0.344 0.000
K92.8 Other specified diseases of digestive system
0.655 0.345 0.000
E40-E46 Malnutrition
0.655 0.345 0.000
M25.74 Osteophyte (Hand)
0.654 0.345 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.654 0.346 0.000
L03.2 Cellulitis of face
0.653 0.347 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.652 0.347 0.000
K83 Other diseases of biliary tract
0.651 0.349 0.000
B07 Viral warts
0.650 0.350 0.000
M65 Synovitis and tenosynovitis
0.650 0.350 0.000
R52.2 Other chronic pain
0.650 0.350 0.000
L10-L14 Bullous disorders
0.649 0.351 0.000
S27 Injury of other and unspecified intrathoracic organs
0.649 0.351 0.000
M22.4 Chondromalacia patellae
0.649 0.351 0.000
M54.55 Low back pain (Thoracolumbar region)
0.648 0.352 0.000
M54.54 Low back pain-Thoracic
0.648 0.352 0.000
M54.53 Low back pain-Cervicothoracic
0.648 0.352 0.000
M54.52 Low back pain-Cervical
0.648 0.352 0.000
M54.51 Low back pain-Occipit-atl-axl
0.648 0.352 0.000
N19 Unspecified renal failure
0.647 0.352 0.000
L50-L54 Urticaria and erythema
0.647 0.353 0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.647 0.353 0.000
E85 Amyloidosis
0.645 0.355 0.000
E84 Cystic fibrosis
0.645 0.355 0.000
E79 Disorders of purine and pyrimidine metabolism
0.645 0.355 0.000
E77 Disorders of glycoprotein metabolism
0.645 0.355 0.000
E76 Disorders of glycosaminoglycan metabolism
0.645 0.355 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.645 0.355 0.000
E74 Other disorders of carbohydrate metabolism
0.645 0.355 0.000
E72 Other disorders of amino-acid metabolism
0.645 0.355 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.645 0.355 0.000
E70 Disorders of aromatic amino-acid metabolism
0.645 0.355 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.645 0.355 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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