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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3764022
log Bayes Factor = 7.4239
Chromosome 12   position 9,833,524  (GRCh37) Explore rs3764022 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.302 0.698
E00-E07 Disorders of thyroid gland
0.000 0.378 0.622
E06 Thyroiditis
0.000 0.388 0.612
E06.3 Autoimmune thyroiditis
0.000 0.392 0.608
E10.3 With ophthalmic complications
0.000 0.435 0.565
E10 Insulin-dependent diabetes mellitus
0.000 0.435 0.565
E10.5 With peripheral circulatory complications
0.000 0.464 0.536
E10.9 Without complications
0.000 0.494 0.506
E10-E14 Diabetes mellitus
0.000 0.497 0.503
E03.5 Myxoedema coma
0.000 0.500 0.500
E03.4 Atrophy of thyroid (acquired)
0.000 0.500 0.500
E03.3 Postinfectious hypothyroidism
0.000 0.500 0.500
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.500 0.500
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.504 0.496
E10.4 With neurological complications
0.000 0.514 0.486
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.521 0.479
E07 Other disorders of thyroid
0.000 0.528 0.472
E10.8 With unspecified complications
0.000 0.528 0.472
E03.1 Congenital hypothyroidism without goitre
0.000 0.541 0.458
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.542 0.458
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.554 0.446
E00 Congenital iodine-deficiency syndrome
0.000 0.554 0.446
E06.4 Drug-induced thyroiditis
0.000 0.561 0.439
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.561 0.439
E06.1 Subacute thyroiditis
0.000 0.561 0.439
E06.0 Acute thyroiditis
0.000 0.561 0.439
E20-E35 Disorders of other endocrine glands
0.000 0.568 0.432
E06.9 Thyroiditis, unspecified
0.000 0.568 0.432
E06.5 Other chronic thyroiditis
0.000 0.580 0.420
E07.8 Other specified disorders of thyroid
0.000 0.591 0.409
E10.7 With multiple complications
0.000 0.595 0.405
E10.0 With coma
0.000 0.598 0.402
E13 Other specified diabetes mellitus
0.000 0.610 0.390
E22 Hyperfunction of pituitary gland
0.000 0.618 0.382
E29 Testicular dysfunction
0.000 0.625 0.375
E10.2 With renal complications
0.000 0.628 0.372
E12 Malnutrition-related diabetes mellitus
0.000 0.640 0.360
E10.6 With other specified complications
0.000 0.646 0.354
E24 Cushing's syndrome
0.000 0.650 0.350
E10.1 With ketoacidosis
0.000 0.651 0.349
E34 Other endocrine disorders
0.000 0.654 0.346
E07.1 Dyshormogenetic goitre
0.000 0.662 0.338
E07.0 Hypersecretion of calcitonin
0.000 0.662 0.338
E23 Hypofunction and other disorders of pituitary gland
0.000 0.662 0.338
E29.1 Testicular hypofunction
0.000 0.666 0.334
E25 Adrenogenital disorders
0.000 0.669 0.331
E22.1 Hyperprolactinaemia
0.000 0.678 0.322
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.680 0.320
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.680 0.320
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.680 0.320
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.680 0.320
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.680 0.320
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.680 0.320
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.680 0.320
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.680 0.320
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.682 0.318
E34.9 Endocrine disorder, unspecified
0.000 0.682 0.318
E13.9 Without complications
0.000 0.686 0.314
E03.8 Other specified hypothyroidism
0.000 0.686 0.313
E20 Hypoparathyroidism
0.000 0.687 0.312
E22.0 Acromegaly and pituitary gigantism
0.000 0.688 0.312
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.690 0.310
E32 Diseases of thymus
0.000 0.690 0.310
E30 Disorders of puberty, not elsewhere classified
0.000 0.690 0.310
E28 Ovarian dysfunction
0.000 0.692 0.308
E23.2 Diabetes insipidus
0.000 0.694 0.306
E24.9 Cushing's syndrome, unspecified
0.000 0.704 0.296
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.720 0.280
E13.8 With unspecified complications
0.000 0.720 0.280
E13.7 With multiple complications
0.000 0.720 0.280
E13.6 With other specified complications
0.000 0.720 0.280
E13.5 With peripheral circulatory complications
0.000 0.720 0.280
E13.4 With neurological complications
0.000 0.720 0.280
E13.2 With renal complications
0.000 0.720 0.280
E13.1 With ketoacidosis
0.000 0.720 0.280
E13.0 With coma
0.000 0.720 0.280
E27 Other disorders of adrenal gland
0.000 0.723 0.277
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.726 0.274
E22.8 Other hyperfunction of pituitary gland
0.000 0.726 0.274
E13.3 With ophthalmic complications
0.000 0.728 0.272
E31 Polyglandular dysfunction
0.000 0.730 0.269
E29.9 Testicular dysfunction, unspecified
0.000 0.731 0.269
E29.8 Other testicular dysfunction
0.000 0.731 0.269
E29.0 Testicular hyperfunction
0.000 0.731 0.269
E28.3 Primary ovarian failure
0.000 0.736 0.264
E40-E46 Malnutrition
0.000 0.738 0.262
E24.0 Pituitary-dependent Cushing's disease
0.000 0.739 0.261
E12.9 Without complications
0.000 0.741 0.258
E12.8 With unspecified complications
0.000 0.741 0.258
E12.7 With multiple complications
0.000 0.741 0.258
E12.6 With other specified complications
0.000 0.741 0.258
E12.5 With peripheral circulatory complications
0.000 0.741 0.258
E12.4 With neurological complications
0.000 0.741 0.258
E12.3 With ophthalmic complications
0.000 0.741 0.258
E12.2 With renal complications
0.000 0.741 0.258
E12.1 With ketoacidosis
0.000 0.741 0.258
E12.0 With coma
0.000 0.741 0.258
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.742 0.258
E24.8 Other Cushing's syndrome
0.000 0.749 0.251
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.749 0.251
E24.3 Ectopic ACTH syndrome
0.000 0.749 0.251
E24.1 Nelson's syndrome
0.000 0.749 0.251
E34.5 Androgen resistance syndrome
0.000 0.751 0.248
E34.4 Constitutional tall stature
0.000 0.751 0.248
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.751 0.248
E34.1 Other hypersecretion of intestinal hormones
0.000 0.751 0.248
E26 Hyperaldosteronism
0.000 0.756 0.244
E34.3 Short stature, not elsewhere classified
0.000 0.756 0.244
E07.9 Disorder of thyroid, unspecified
0.000 0.757 0.243
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.757 0.243
E23.1 Drug-induced hypopituitarism
0.000 0.757 0.243
E23.0 Hypopituitarism
0.000 0.757 0.243
E25.9 Adrenogenital disorder, unspecified
0.000 0.763 0.237
E25.8 Other adrenogenital disorders
0.000 0.763 0.237
E27.9 Disorder of adrenal gland, unspecified
0.000 0.764 0.236
E27.1 Primary adrenocortical insufficiency
0.000 0.768 0.232
E24.2 Drug-induced Cushing's syndrome
0.000 0.768 0.231
E15 Nondiabetic hypoglycaemic coma
0.000 0.772 0.228
E65-E68 Obesity and other hyperalimentation
0.000 0.773 0.227
E20.9 Hypoparathyroidism, unspecified
0.000 0.773 0.226
E20.8 Other hypoparathyroidism
0.000 0.776 0.224
E20.1 Pseudohypoparathyroidism
0.000 0.776 0.224
E20.0 Idiopathic hypoparathyroidism
0.000 0.776 0.224
E30.9 Disorder of puberty, unspecified
0.000 0.777 0.222
E30.8 Other disorders of puberty
0.000 0.777 0.222
E30.1 Precocious puberty
0.000 0.777 0.222
E30.0 Delayed puberty
0.000 0.777 0.222
E32.9 Disease of thymus, unspecified
0.000 0.777 0.222
E32.8 Other diseases of thymus
0.000 0.777 0.222
E32.1 Abscess of thymus
0.000 0.777 0.222
E32.0 Persistent hyperplasia of thymus
0.000 0.777 0.222
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.777 0.222
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.777 0.222
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.777 0.222
E28.9 Ovarian dysfunction, unspecified
0.000 0.779 0.221
E28.8 Other ovarian dysfunction
0.000 0.779 0.221
E28.1 Androgen excess
0.000 0.779 0.221
E28.0 Oestrogen excess
0.000 0.779 0.221
E34.0 Carcinoid syndrome
0.000 0.784 0.216
E23.7 Disorder of pituitary gland, unspecified
0.000 0.797 0.203
E27.5 Adrenomedullary hyperfunction
0.000 0.801 0.199
E27.0 Other adrenocortical overactivity
0.000 0.801 0.199
E23.6 Other disorders of pituitary gland
0.000 0.802 0.198
E34.8 Other specified endocrine disorders
0.000 0.804 0.196
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.804 0.196
E31.9 Polyglandular dysfunction, unspecified
0.000 0.806 0.193
E31.8 Other polyglandular dysfunction
0.000 0.806 0.193
E31.1 Polyglandular hyperfunction
0.000 0.806 0.193
E16 Other disorders of pancreatic internal secretion
0.000 0.809 0.191
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.812 0.188
E45 Retarded development following protein-energy malnutrition
0.000 0.812 0.188
E43 Unspecified severe protein-energy malnutrition
0.000 0.812 0.188
E42 Marasmic kwashiorkor
0.000 0.812 0.188
E41 Nutritional marasmus
0.000 0.812 0.188
E40 Kwashiorkor
0.000 0.812 0.188
E14 Unspecified diabetes mellitus
0.000 0.821 0.179
E27.2 Addisonian crisis
0.000 0.824 0.176
E26.8 Other hyperaldosteronism
0.000 0.825 0.175
E26.1 Secondary hyperaldosteronism
0.000 0.825 0.175
E26.9 Hyperaldosteronism, unspecified
0.000 0.828 0.171
E27.8 Other specified disorders of adrenal gland
0.000 0.829 0.171
E67 Other hyperalimentation
0.000 0.837 0.163
E68 Sequelae of hyperalimentation
0.000 0.837 0.163
E50-E64 Other nutritional deficiencies
0.000 0.846 0.153
E31.0 Autoimmune polyglandular failure
0.001 0.847 0.152
E65 Localised adiposity
0.000 0.853 0.146
E14.6 With other specified complications
0.000 0.859 0.141
E14.2 Withrenal complications
0.000 0.862 0.137
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.863 0.137
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.863 0.137
E16.4 Abnormal secretion of gastrin
0.000 0.863 0.137
E16.3 Increased secretion of glucagon
0.000 0.863 0.137
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.864 0.136
E16.2 Hypoglycaemia, unspecified
0.000 0.865 0.135
E44.1 Mild protein-energy malnutrition
0.000 0.865 0.135
E44.0 Moderate protein-energy malnutrition
0.000 0.865 0.135
E28.2 Polycystic ovarian syndrome
0.000 0.865 0.135
E14.1 With ketoacidosis
0.000 0.867 0.133
E14.7 With multiple complications
0.000 0.871 0.128
E14.0 With coma
0.000 0.871 0.128
E14.8 With unspecified complications
0.000 0.874 0.126
E16.1 Other hypoglycaemia
0.000 0.874 0.126
E14.5 With peripheral circulatory complications
0.000 0.876 0.124
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.881 0.118
E67.8 Other specified hyperalimentation
0.000 0.883 0.117
E67.3 Hypervitaminosis D
0.000 0.883 0.117
E67.2 Megavitamin-B6 syndrome
0.000 0.883 0.117
E67.1 Hypercarotenaemia
0.000 0.883 0.117
E67.0 Hypervitaminosis A
0.000 0.883 0.117
E26.0 Primary hyperaldosteronism
0.000 0.884 0.116
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.890 0.110
E63 Other nutritional deficiencies
0.000 0.890 0.110
E56 Other vitamin deficiencies
0.000 0.890 0.110
E50 Vitamin A deficiency
0.000 0.890 0.110
E60 Dietary zinc deficiency
0.000 0.890 0.110
E59 Dietary selenium deficiency
0.000 0.890 0.110
E54 Ascorbic acid deficiency
0.000 0.890 0.110
E52 Niacin deficiency [pellagra]
0.000 0.890 0.110
E58 Dietary calcium deficiency
0.000 0.893 0.107
E51 Thiamine deficiency
0.000 0.893 0.107
E14.4 With neurological complications
0.000 0.895 0.105
E21.2 Other hyperparathyroidism
0.000 0.901 0.099
E21.4 Other specified disorders of parathyroid gland
0.000 0.901 0.099
E61 Deficiency of other nutrient elements
0.000 0.902 0.098
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.902 0.097
E46 Unspecified protein-energy malnutrition
0.000 0.906 0.094
E14.3 With ophthalmic complications
0.000 0.914 0.086
E11 Non-insulin-dependent diabetes mellitus
0.000 0.916 0.084
E04 Other non-toxic goitre
0.000 0.919 0.081
E50.9 Vitamin A deficiency, unspecified
0.000 0.921 0.079
E50.8 Other manifestations of vitamin A deficiency
0.000 0.921 0.079
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.921 0.079
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.921 0.079
E50.5 Vitamin A deficiency with night blindness
0.000 0.921 0.079
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.921 0.079
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.921 0.079
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.921 0.079
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.921 0.079
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.921 0.079
E56.9 Vitamin deficiency, unspecified
0.000 0.921 0.079
E56.8 Deficiency of other vitamins
0.000 0.921 0.079
E56.1 Deficiency of vitamin K
0.000 0.921 0.079
E56.0 Deficiency of vitamin E
0.000 0.921 0.079
E63.9 Nutritional deficiency, unspecified
0.000 0.921 0.079
E63.8 Other specified nutritional deficiencies
0.000 0.921 0.079
E63.1 Imbalance of constituents of food intake
0.000 0.921 0.079
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.921 0.079
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.921 0.079
E64.8 Sequelae of other nutritional deficiencies
0.000 0.921 0.079
E64.3 Sequelae of rickets
0.000 0.921 0.079
E64.2 Sequelae of vitamin C deficiency
0.000 0.921 0.079
E64.1 Sequelae of vitamin A deficiency
0.000 0.921 0.079
E64.0 Sequelae of protein-energy malnutrition
0.000 0.921 0.079
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.922 0.078
E21.3 Hyperparathyroidism, unspecified
0.000 0.923 0.077
E51.9 Thiamine deficiency, unspecified
0.000 0.923 0.077
E51.8 Other manifestations of thiamine deficiency
0.000 0.923 0.077
E51.1 Beriberi
0.000 0.923 0.077
E27.4 Other and unspecified adrenocortical insufficiency
0.001 0.925 0.074
E66 Obesity
0.000 0.926 0.074
E55 Vitamin D deficiency
0.000 0.927 0.073
E51.2 Wernicke's encephalopathy
0.000 0.927 0.073
E11.1 With ketoacidosis
0.000 0.929 0.071
E61.9 Deficiency of nutrient element, unspecified
0.000 0.930 0.070
E61.8 Deficiency of other specified nutrient elements
0.000 0.930 0.070
E61.7 Deficiency of multiple nutrient elements
0.000 0.930 0.070
E61.6 Vanadium deficiency
0.000 0.930 0.070
E61.5 Molybdenum deficiency
0.000 0.930 0.070
E61.4 Chromium deficiency
0.000 0.930 0.070
E61.3 Manganese deficiency
0.000 0.930 0.070
E61.0 Copper deficiency
0.000 0.930 0.070
E61.2 Magnesium deficiency
0.000 0.933 0.066
E11.8 With unspecified complications
0.000 0.934 0.066
E53 Deficiency of other B group vitamins
0.000 0.935 0.064
E61.1 Iron deficiency
0.000 0.938 0.062
E11.7 With multiple complications
0.000 0.940 0.060
E04.0 Non-toxic diffuse goitre
0.000 0.941 0.059
E04.8 Other specified non-toxic goitre
0.000 0.941 0.059
E66.0 Obesity due to excess calories
0.000 0.943 0.057
E11.9 Without complications
0.000 0.943 0.057
E11.5 With peripheral circulatory complications
0.000 0.946 0.054
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.947 0.053
E66.1 Drug-induced obesity
0.000 0.947 0.053
E11.6 With other specified complications
0.000 0.947 0.053
E55.0 Rickets, active
0.000 0.947 0.053
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.948 0.051
E11.4 With neurological complications
0.000 0.948 0.052
E53.1 Pyridoxine deficiency
0.000 0.953 0.046
E53.0 Riboflavin deficiency
0.000 0.953 0.046
E14.9 Without complications
0.000 0.957 0.043
E53.9 Vitamin B deficiency, unspecified
0.000 0.959 0.041
E21.0 Primary hyperparathyroidism
0.000 0.959 0.041
E11.0 With coma
0.000 0.962 0.038
E05.5 Thyroid crisis or storm
0.000 0.963 0.037
E05.4 Thyrotoxicosis factitia
0.000 0.963 0.037
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.963 0.037
E66.8 Other obesity
0.000 0.966 0.034
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.001 0.967 0.032
E11.3 With ophthalmic complications
0.000 0.967 0.033
E04.2 Non-toxic multinodular goitre
0.000 0.969 0.031
E05.8 Other thyrotoxicosis
0.001 0.970 0.029
E05.9 Thyrotoxicosis, unspecified
0.000 0.977 0.023
E04.9 Non-toxic goitre, unspecified
0.000 0.981 0.019
E11.2 With renal complications
0.000 0.981 0.019
D86 Sarcoidosis
0.017 0.983 0.000
D86.0 Sarcoidosis of lung
0.017 0.983 0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.001 0.984 0.015
E55.9 Vitamin D deficiency, unspecified
0.000 0.984 0.016
E53.8 Deficiency of other specified B group vitamins
0.000 0.985 0.015
D86.9 Sarcoidosis, unspecified
0.015 0.985 0.000
D86.1 Sarcoidosis of lymph nodes
0.015 0.985 0.000
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.014 0.986 0.000
E04.1 Non-toxic single thyroid nodule
0.000 0.986 0.014
S19.9 Unspecified injury of neck
0.000 0.987 0.013
D86.8 Sarcoidosis of other and combined sites
0.013 0.987 0.000
N75.0 Cyst of Bartholin's gland
0.000 0.987 0.013
K60.3 Anal fistula
0.013 0.987 0.000
D86.3 Sarcoidosis of skin
0.013 0.987 0.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.989 0.011
R80 Isolated proteinuria
0.010 0.990 0.000
D80-D89 Certain disorders involving the immune mechanism
0.008 0.992 0.000
S05.0 Injury of conjunctiva and corneal abrasion without mention of foreign body
0.008 0.992 0.000
S05 Injury of eye and orbit
0.007 0.993 0.000
D80 Immunodeficiency with predominantly antibody defects
0.007 0.993 0.000
R41.8 Other and unspecified symptoms and signs involving cognitive functions and awareness
0.007 0.993 0.000
K90.0 Coeliac disease
0.000 0.993 0.007
S05.8 Other injuries of eye and orbit
0.007 0.993 0.000
S05.9 Injury of eye and orbit, part unspecified
0.007 0.993 0.000
S19 Other and unspecified injuries of neck
0.000 0.993 0.007
S05.1 Contusion of eyeball and orbital tissues
0.007 0.993 0.000
D84 Other immunodeficiencies
0.006 0.993 0.000
D82 Immunodeficiency associated with other major defects
0.006 0.993 0.000
S60.8 Other superficial injuries of wrist and hand
0.006 0.994 0.000
S05.4 Penetrating wound of orbit with or without foreign body
0.006 0.994 0.000
D81 Combined immunodeficiencies
0.006 0.994 0.000
S05.6 Penetrating wound of eyeball without foreign body
0.006 0.994 0.000
R63.0 Anorexia
0.006 0.994 0.000
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.006 0.994 0.000
D83 Common variable immunodeficiency
0.006 0.994 0.000
S05.3 Ocular laceration without prolapse or loss of intraocular tissue
0.006 0.994 0.000
S05.5 Penetrating wound of eyeball with foreign body
0.006 0.994 0.000
E70-E90 Metabolic disorders
0.000 0.994 0.006
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.006 0.994 0.000
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.006 0.994 0.000
S05.7 Avulsion of eye
0.005 0.994 0.000
E85 Amyloidosis
0.000 0.994 0.006
D84.8 Other specified immunodeficiencies
0.005 0.995 0.000
E85.4 Organ-limited amyloidosis
0.000 0.995 0.005
D80.8 Other immunodeficiencies with predominantly antibody defects
0.005 0.995 0.000
D80.7 Transient hypogammaglobulinaemia of infancy
0.005 0.995 0.000
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.005 0.995 0.000
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.005 0.995 0.000
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.005 0.995 0.000
D80.0 Hereditary hypogammaglobulinaemia
0.005 0.995 0.000
K60 Fissure and fistula of anal and rectal regions
0.005 0.995 0.000
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.005 0.995 0.000
D80.1 Nonfamilial hypogammaglobulinaemia
0.005 0.995 0.000
D82.1 Di George's syndrome
0.005 0.995 0.000
S19.8 Other specified injuries of neck
0.000 0.995 0.005
S60.0 Contusion of finger(s) without damage to nail
0.005 0.995 0.000
K60.1 Chronic anal fissure
0.005 0.995 0.000
S19.7 Multiple injuries of neck
0.000 0.995 0.005
D84.1 Defects in the complement system
0.005 0.995 0.000
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.005 0.995 0.000
D82.9 Immunodeficiency associated with major defect, unspecified
0.005 0.995 0.000
D82.8 Immunodeficiency associated with other specified major defects
0.005 0.995 0.000
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.005 0.995 0.000
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.005 0.995 0.000
D82.2 Immunodeficiency with short-limbed stature
0.005 0.995 0.000
D82.0 Wiskott-Aldrich syndrome
0.005 0.995 0.000
Z63.7 Other stressful life events affecting family and household
0.005 0.995 0.000
E79 Disorders of purine and pyrimidine metabolism
0.000 0.995 0.005
S60 Superficial injury of wrist and hand
0.005 0.995 0.000
D81.9 Combined immunodeficiency, unspecified
0.005 0.995 0.000
D81.8 Other combined immunodeficiencies
0.005 0.995 0.000
D81.7 Major histocompatibility complex class II deficiency
0.005 0.995 0.000
D81.6 Major histocompatibility complex class I deficiency
0.005 0.995 0.000
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.005 0.995 0.000
D81.4 Nezelof's syndrome
0.005 0.995 0.000
D81.3 Adenosine deaminase [ADA] deficiency
0.005 0.995 0.000
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.005 0.995 0.000
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.005 0.995 0.000
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.005 0.995 0.000
E84 Cystic fibrosis
0.000 0.995 0.005
D84.9 Immunodeficiency, unspecified
0.004 0.995 0.000
E85.3 Secondary systemic amyloidosis
0.000 0.995 0.004
D83.8 Other common variable immunodeficiencies
0.004 0.995 0.000
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.004 0.995 0.000
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.004 0.995 0.000
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.004 0.995 0.000
M89.9 Disorder of bone, unspecified
0.005 0.995 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.995 0.004
K60.5 Anorectal fistula
0.004 0.995 0.000
D89.9 Disorder involving the immune mechanism, unspecified
0.004 0.996 0.000
S05.2 Ocular laceration and rupture with prolapse or loss of intraocular tissue
0.004 0.996 0.000
Z63.8 Other specified problems related to primary support group
0.004 0.996 0.000
D89.0 Polyclonal hypergammaglobulinaemia
0.004 0.996 0.000
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.004 0.996 0.000
E77 Disorders of glycoprotein metabolism
0.000 0.996 0.004
E76 Disorders of glycosaminoglycan metabolism
0.000 0.996 0.004
E72 Other disorders of amino-acid metabolism
0.000 0.996 0.004
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.996 0.004
E70 Disorders of aromatic amino-acid metabolism
0.000 0.996 0.004
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.996 0.004
D89.3 Immune reconstitution syndrome
0.004 0.996 0.000
K51.2 Ulcerative (chronic) proctitis
0.000 0.996 0.004
K60.0 Acute anal fissure
0.004 0.996 0.000
E85.8 Other amyloidosis
0.000 0.996 0.004
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.996 0.004
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.996 0.004
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.996 0.004
D83.9 Common variable immunodeficiency, unspecified
0.004 0.996 0.000
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.996 0.004
E85.9 Amyloidosis, unspecified
0.000 0.996 0.004
S60.2 Contusion of other parts of wrist and hand
0.004 0.996 0.000
M89.97 Disorder of bone, unspecified (Ankle and foot)
0.004 0.996 0.000
M89.95 Disorder of bone, unspecified (Pelvic region and thigh)
0.004 0.996 0.000
E88 Other metabolic disorders
0.000 0.996 0.004
E84.9 Cystic fibrosis, unspecified
0.000 0.996 0.004
M89.94 Disorder of bone, unspecified (Hand)
0.004 0.996 0.000
Z63 Other problems related to primary support group, including family circumstances
0.004 0.996 0.000
M89.92 Disorder of bone, unspecified (Upper arm)
0.004 0.996 0.000
D89.1 Cryoglobulinaemia
0.004 0.996 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.996 0.004
M89.98 Disorder of bone, unspecified (Other)
0.004 0.996 0.000
M89.90 Disorder of bone, unspecified (Multiple sites)
0.004 0.996 0.000
D89.2 Hypergammaglobulinaemia, unspecified
0.004 0.996 0.000
K60.4 Rectal fistula
0.004 0.996 0.000
S60.7 Multiple superficial injuries of wrist and hand
0.004 0.996 0.000
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.996 0.004
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.996 0.004
E79.1 Lesch-Nyhan syndrome
0.000 0.996 0.004
D21.1 Connective and other soft tissue of upper limb, including shoulder
0.000 0.996 0.004
E80.2 Other porphyria
0.000 0.996 0.004
E84.8 Cystic fibrosis with other manifestations
0.000 0.996 0.003
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.996 0.003
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.996 0.003
E75.5 Other lipid storage disorders
0.000 0.996 0.003
Z50.2 Alcohol rehabilitation
0.004 0.996 0.000
M89.99 Disorder of bone, unspecified (Site unspecified)
0.003 0.996 0.000
M89.93 Disorder of bone, unspecified (Forearm)
0.003 0.996 0.000
M89.91 Disorder of bone, unspecified (Shoulder region)
0.003 0.996 0.000
Z63.6 Dependent relative needing care at home
0.003 0.996 0.000
E74 Other disorders of carbohydrate metabolism
0.000 0.996 0.003
E75.6 Lipid storage disorder, unspecified
0.000 0.996 0.003
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.996 0.003
E75.3 Sphingolipidosis, unspecified
0.000 0.996 0.003
E75.2 Other sphingolipidosis
0.000 0.996 0.003
E75.1 Other gangliosidosis
0.000 0.996 0.003
E75.0 GM2 gangliosidosis
0.000 0.996 0.003
Z63.4 Disappearance and death of family member
0.003 0.996 0.000
K44.0 Diaphragmatic hernia with obstruction, without gangrene
0.003 0.997 0.000
M89.96 Disorder of bone, unspecified (Lower leg)
0.003 0.997 0.000
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.997 0.003
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.997 0.003
E70.3 Albinism
0.000 0.997 0.003
E70.2 Disorders of tyrosine metabolism
0.000 0.997 0.003
E70.1 Other hyperphenylalaninaemias
0.000 0.997 0.003
E70.0 Classical phenylketonuria
0.000 0.997 0.003
E71.3 Disorders of fatty-acid metabolism
0.000 0.997 0.003
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.997 0.003
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.997 0.003
E71.0 Maple-syrup-urine disease
0.000 0.997 0.003
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.997 0.003
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.997 0.003
E72.5 Disorders of glycine metabolism
0.000 0.997 0.003
E72.4 Disorders of ornithine metabolism
0.000 0.997 0.003
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.997 0.003
E72.2 Disorders of urea cycle metabolism
0.000 0.997 0.003
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.997 0.003
E72.0 Disorders of amino-acid transport
0.000 0.997 0.003
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.997 0.003
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.997 0.003
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.997 0.003
E76.2 Other mucopolysaccharidoses
0.000 0.997 0.003
E76.1 Mucopolysaccharidosis, type II
0.000 0.997 0.003
E76.0 Mucopolysaccharidosis, type I
0.000 0.997 0.003
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.997 0.003
E77.8 Other disorders of glycoprotein metabolism
0.000 0.997 0.003
E77.1 Defects in glycoprotein degradation
0.000 0.997 0.003
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.997 0.003
S60.9 Superficial injury of wrist and hand, unspecified
0.003 0.997 0.000
E73 Lactose intolerance
0.000 0.997 0.003
E88.9 Metabolic disorder, unspecified
0.000 0.997 0.003
S60.1 Contusion of finger(s) with damage to nail
0.003 0.997 0.000
H26.8 Other specified cataract
0.003 0.997 0.000
E88.2 Lipomatosis, not elsewhere classified
0.000 0.997 0.003
E88.3 Tumour lysis syndrome
0.000 0.997 0.003
Z63.5 Disruption of family by separation and divorce
0.003 0.997 0.000
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.997 0.003
Z63.9 Problem related to primary support group, unspecified
0.003 0.997 0.000
Z63.3 Absence of family member
0.003 0.997 0.000
Z63.2 Inadequate family support
0.003 0.997 0.000
Z63.1 Problems in relationship with parents and in-laws
0.003 0.997 0.000
E80.1 Porphyria cutanea tarda
0.000 0.997 0.003
N75 Diseases of Bartholin's gland
0.000 0.997 0.003
E66.9 Obesity, unspecified
0.000 0.997 0.003
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.997 0.003
E80.5 Crigler-Najjar syndrome
0.000 0.997 0.003
E80.3 Defects of catalase and peroxydase
0.000 0.997 0.003
E80.0 Hereditary erythropoietic porphyria
0.000 0.997 0.003
O46.9 Antepartum haemorrhage, unspecified
0.000 0.997 0.003
K72.0 Acute and subacute hepatic failure
0.000 0.997 0.003
M89 Other disorders of bone
0.003 0.997 0.000
E88.8 Other specified metabolic disorders
0.000 0.997 0.003
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.997 0.003
M89.3 Hypertrophy of bone
0.003 0.997 0.000
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.997 0.002
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.997 0.002
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.997 0.002
E74.2 Disorders of galactose metabolism
0.000 0.997 0.002
E74.1 Disorders of fructose metabolism
0.000 0.997 0.002
E74.0 Glycogen storage disease
0.000 0.997 0.002
E80.6 Other disorders of bilirubin metabolism
0.000 0.997 0.003
L73.2 Hidradenitis suppurativa
0.000 0.997 0.003
Z50.5 Speech therapy
0.003 0.997 0.000
M89.37 Hypertrophy of bone (Ankle and foot)
0.003 0.997 0.000
E73.8 Other lactose intolerance
0.000 0.997 0.002
E73.1 Secondary lactase deficiency
0.000 0.997 0.002

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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